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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for TACC3

check button Gene summary
Gene informationGene symbol

TACC3

Gene ID

10460

Gene nametransforming acidic coiled-coil containing protein 3
SynonymsERIC-1|ERIC1
Cytomap

4p16.3

Type of geneprotein-coding
Descriptiontransforming acidic coiled-coil-containing protein 3
Modification date20180523
UniProtAcc

Q9Y6A5

ContextPubMed: TACC3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for TACC3 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for TACC3

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for TACC3

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_42126441725147:1725310:1725428:1725597:1729434:17297931725428:1725597ENSG00000013810.14ENST00000467746.1
exon_skip_42126641725147:1725310:1725454:1725597:1729434:17297931725454:1725597ENSG00000013810.14ENST00000484651.1,ENST00000493975.1,ENST00000313288.4,ENST00000458173.3
exon_skip_42127041725544:1725597:1729434:1730514:1732613:17326891729434:1730514ENSG00000013810.14ENST00000484651.1,ENST00000313288.4
exon_skip_42127241730130:1730514:1732613:1732689:1732898:17329581732613:1732689ENSG00000013810.14ENST00000484651.1,ENST00000470136.1,ENST00000313288.4
exon_skip_42127641732613:1732689:1732898:1733028:1736999:17370521732898:1733028ENSG00000013810.14ENST00000484651.1,ENST00000485989.2,ENST00000466077.1,ENST00000313288.4
exon_skip_42127741737457:1737561:1738967:1739055:1739324:17393721738967:1739055ENSG00000013810.14ENST00000484651.1,ENST00000466077.1,ENST00000313288.4
exon_skip_42128341741685:1741729:1742552:1742713:1746244:17463511742552:1742713ENSG00000013810.14ENST00000313288.4

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for TACC3

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_42126441725147:1725310:1725428:1725597:1729434:17297931725428:1725597ENSG00000013810.14ENST00000467746.1
exon_skip_42126641725147:1725310:1725454:1725597:1729434:17297931725454:1725597ENSG00000013810.14ENST00000484651.1,ENST00000313288.4,ENST00000493975.1,ENST00000458173.3
exon_skip_42127041725544:1725597:1729434:1730514:1732613:17326891729434:1730514ENSG00000013810.14ENST00000484651.1,ENST00000313288.4
exon_skip_42127241730130:1730514:1732613:1732689:1732898:17329581732613:1732689ENSG00000013810.14ENST00000484651.1,ENST00000313288.4,ENST00000470136.1
exon_skip_42127641732613:1732689:1732898:1733028:1736999:17370521732898:1733028ENSG00000013810.14ENST00000485989.2,ENST00000484651.1,ENST00000313288.4,ENST00000466077.1
exon_skip_42127741737457:1737561:1738967:1739055:1739324:17393721738967:1739055ENSG00000013810.14ENST00000484651.1,ENST00000313288.4,ENST00000466077.1
exon_skip_42128341741685:1741729:1742552:1742713:1746244:17463511742552:1742713ENSG00000013810.14ENST00000313288.4

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TACC3

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000031328817254541725597Frame-shift
ENST0000031328817326131732689Frame-shift
ENST0000031328817328981733028Frame-shift
ENST0000031328817389671739055Frame-shift
ENST0000031328817425521742713Frame-shift
ENST0000031328817294341730514In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000031328817254541725597Frame-shift
ENST0000031328817326131732689Frame-shift
ENST0000031328817328981733028Frame-shift
ENST0000031328817389671739055Frame-shift
ENST0000031328817425521742713Frame-shift
ENST0000031328817294341730514In-frame

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Infer the effects of exon skipping event on protein functional features for TACC3

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003132882798838172943417305144121491102461
ENST000003132882798838172943417305144121491102461
ENST000003132882798838172943417305144121491102461

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003132882798838172943417305144121491102461
ENST000003132882798838172943417305144121491102461
ENST000003132882798838172943417305144121491102461

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9Y6A51024612838ChainID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
Q9Y6A51024612838ChainID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
Q9Y6A51024612838ChainID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
Q9Y6A5102461155160Compositional biasNote=Poly-Ser
Q9Y6A5102461155160Compositional biasNote=Poly-Ser
Q9Y6A5102461155160Compositional biasNote=Poly-Ser
Q9Y6A5102461175175Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
Q9Y6A5102461175175Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
Q9Y6A5102461175175Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
Q9Y6A5102461177177Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461177177Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461177177Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461250250Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461250250Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461250250Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461317317Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y6A5102461317317Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y6A5102461317317Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y6A5102461402402Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y6A5102461402402Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y6A5102461402402Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y6A5102461434434Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
Q9Y6A5102461434434Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
Q9Y6A5102461434434Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
Q9Y6A5102461143143Natural variantID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
Q9Y6A5102461143143Natural variantID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
Q9Y6A5102461143143Natural variantID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
Q9Y6A5102461275275Natural variantID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
Q9Y6A5102461275275Natural variantID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
Q9Y6A5102461275275Natural variantID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
Q9Y6A5102461287287Natural variantID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
Q9Y6A5102461287287Natural variantID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
Q9Y6A5102461287287Natural variantID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
Q9Y6A5102461342342Sequence conflictNote=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461342342Sequence conflictNote=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461342342Sequence conflictNote=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461406406Sequence conflictNote=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461406406Sequence conflictNote=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461406406Sequence conflictNote=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9Y6A51024612838ChainID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
Q9Y6A51024612838ChainID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
Q9Y6A51024612838ChainID=PRO_0000179990;Note=Transforming acidic coiled-coil-containing protein 3
Q9Y6A5102461155160Compositional biasNote=Poly-Ser
Q9Y6A5102461155160Compositional biasNote=Poly-Ser
Q9Y6A5102461155160Compositional biasNote=Poly-Ser
Q9Y6A5102461175175Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
Q9Y6A5102461175175Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
Q9Y6A5102461175175Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
Q9Y6A5102461177177Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461177177Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461177177Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461250250Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461250250Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461250250Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y6A5102461317317Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y6A5102461317317Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y6A5102461317317Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y6A5102461402402Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y6A5102461402402Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y6A5102461402402Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q9Y6A5102461434434Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
Q9Y6A5102461434434Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
Q9Y6A5102461434434Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:23186163
Q9Y6A5102461143143Natural variantID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
Q9Y6A5102461143143Natural variantID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
Q9Y6A5102461143143Natural variantID=VAR_053714;Note=E->K;Dbxref=dbSNP:rs34205238
Q9Y6A5102461275275Natural variantID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
Q9Y6A5102461275275Natural variantID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
Q9Y6A5102461275275Natural variantID=VAR_053715;Note=C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17132047,PMID:11298601,PMID:15489334
Q9Y6A5102461287287Natural variantID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
Q9Y6A5102461287287Natural variantID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
Q9Y6A5102461287287Natural variantID=VAR_053716;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11298601,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1063743,PMID:11298601,PMID:15489334
Q9Y6A5102461342342Sequence conflictNote=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461342342Sequence conflictNote=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461342342Sequence conflictNote=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461406406Sequence conflictNote=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461406406Sequence conflictNote=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y6A5102461406406Sequence conflictNote=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305


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SNVs in the skipped exons for TACC3

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
TACC3_BRCA_exon_skip_421283_psi_boxplot.png
boxplot
TACC3_ESCA_exon_skip_421270_psi_boxplot.png
boxplot
TACC3_HNSC_exon_skip_421270_psi_boxplot.png
boxplot
TACC3_LUAD_exon_skip_421270_psi_boxplot.png
boxplot
TACC3_LUAD_exon_skip_421283_psi_boxplot.png
boxplot
TACC3_SKCM_exon_skip_421283_psi_boxplot.png
boxplot
TACC3_STAD_exon_skip_421270_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_421270
1729435173051417295161729516Frame_Shift_DelG-p.L129fs
LIHCTCGA-G3-A3CJ-01exon_skip_421270
1729435173051417295161729516Frame_Shift_DelG-p.L129fs
LIHCTCGA-DD-A3A0-01exon_skip_421270
1729435173051417296451729645Frame_Shift_DelA-p.G172fs
HNSCTCGA-F7-7848-01exon_skip_421270
1729435173051417303081730308Frame_Shift_DelC-p.D393fs
LIHCTCGA-DD-A3A0-01exon_skip_421270
1729435173051417303081730308Frame_Shift_DelC-p.D393fs
STADTCGA-HU-A4GN-01exon_skip_421270
1729435173051417303081730308Frame_Shift_DelC-p.D393fs
LIHCTCGA-G3-A3CJ-01exon_skip_421276
1732899173302817329661732966Frame_Shift_DelC-p.T510fs
SKCMTCGA-GN-A4U8-06exon_skip_421283
1742553174271317426851742688Frame_Shift_DelAGAA-p.QK732fs
ESCATCGA-L5-A8NM-01exon_skip_421270
1729435173051417303071730308Frame_Shift_Ins-Cp.A393fs
ESCATCGA-L5-A8NM-01exon_skip_421270
1729435173051417303071730308Frame_Shift_Ins-Cp.D393fs
ESCATCGA-L5-A8NM-01exon_skip_421270
1729435173051417303071730308Frame_Shift_Ins-Cp.M396fs
STADTCGA-BR-4370-01exon_skip_421270
1729435173051417303071730308Frame_Shift_Ins-Cp.D393fs
STADTCGA-BR-4370-01exon_skip_421270
1729435173051417303081730309Frame_Shift_Ins-Cp.D393fs
CESCTCGA-BI-A20A-01exon_skip_421276
1732899173302817328981732899Frame_Shift_Ins-GAGAp.A490fs
SKCMTCGA-D3-A2JH-06exon_skip_421283
1742553174271317425581742559Frame_Shift_Ins-Tp.S690fs
LUADTCGA-38-4630-01exon_skip_421270
1729435173051417304351730435Nonsense_MutationGTp.E436*
BRCATCGA-AC-A23C-01exon_skip_421283
1742553174271317425881742588Nonsense_MutationGTp.E700*
LUADTCGA-97-8174-01exon_skip_421283
1742553174271317426451742645Nonsense_MutationGTp.E719*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
TACC3_1741685_1741729_1742552_1742713_1746244_1746351_TCGA-D3-A2JH-06Sample: TCGA-D3-A2JH-06
Cancer type: SKCM
ESID: exon_skip_421283
Skipped exon start: 1742553
Skipped exon end: 1742713
Mutation start: 1742558
Mutation end: 1742559
Mutation type: Frame_Shift_Ins
Reference seq: -
Mutation seq: T
AAchange: p.S690fs
exon_skip_372215_SKCM_TCGA-D3-A2JH-06.png
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exon_skip_421283_SKCM_TCGA-D3-A2JH-06.png
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TACC3_1741685_1741729_1742552_1742713_1746244_1746351_TCGA-GN-A4U8-06Sample: TCGA-GN-A4U8-06
Cancer type: SKCM
ESID: exon_skip_421283
Skipped exon start: 1742553
Skipped exon end: 1742713
Mutation start: 1742685
Mutation end: 1742688
Mutation type: Frame_Shift_Del
Reference seq: AGAA
Mutation seq: -
AAchange: p.QK732fs
exon_skip_421283_SKCM_TCGA-GN-A4U8-06.png
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exon_skip_62256_SKCM_TCGA-GN-A4U8-06.png
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TACC3_1725544_1725597_1729434_1730514_1732613_1732689_TCGA-38-4630-01Sample: TCGA-38-4630-01
Cancer type: LUAD
ESID: exon_skip_421270
Skipped exon start: 1729435
Skipped exon end: 1730514
Mutation start: 1730435
Mutation end: 1730435
Mutation type: Nonsense_Mutation
Reference seq: G
Mutation seq: T
AAchange: p.E436*
exon_skip_290783_LUAD_TCGA-38-4630-01.png
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exon_skip_421270_LUAD_TCGA-38-4630-01.png
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TACC3_1725544_1725597_1729434_1730514_1732613_1732689_TCGA-L5-A8NM-01Sample: TCGA-L5-A8NM-01
Cancer type: ESCA
ESID: exon_skip_421270
Skipped exon start: 1729435
Skipped exon end: 1730514
Mutation start: 1730307
Mutation end: 1730308
Mutation type: Frame_Shift_Ins
Reference seq: -
Mutation seq: C
AAchange: p.D393fs
TACC3_1725544_1725597_1729434_1730514_1732613_1732689_TCGA-L5-A8NM-01Sample: TCGA-L5-A8NM-01
Cancer type: ESCA
ESID: exon_skip_421270
Skipped exon start: 1729435
Skipped exon end: 1730514
Mutation start: 1730307
Mutation end: 1730308
Mutation type: Frame_Shift_Ins
Reference seq: -
Mutation seq: C
AAchange: p.A393fs
TACC3_1725544_1725597_1729434_1730514_1732613_1732689_TCGA-L5-A8NM-01Sample: TCGA-L5-A8NM-01
Cancer type: ESCA
ESID: exon_skip_421270
Skipped exon start: 1729435
Skipped exon end: 1730514
Mutation start: 1730307
Mutation end: 1730308
Mutation type: Frame_Shift_Ins
Reference seq: -
Mutation seq: C
AAchange: p.M396fs
exon_skip_126510_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_145922_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_20931_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_290909_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_301129_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_308211_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_308974_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_310302_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_329666_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_330701_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_330704_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_356820_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_356824_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_370065_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_389081_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_421270_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_433436_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_461351_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_461353_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_464726_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_47552_ESCA_TCGA-L5-A8NM-01.png
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exon_skip_517614_ESCA_TCGA-L5-A8NM-01.png
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TACC3_1725544_1725597_1729434_1730514_1732613_1732689_TCGA-F7-7848-01Sample: TCGA-F7-7848-01
Cancer type: HNSC
ESID: exon_skip_421270
Skipped exon start: 1729435
Skipped exon end: 1730514
Mutation start: 1730308
Mutation end: 1730308
Mutation type: Frame_Shift_Del
Reference seq: C
Mutation seq: -
AAchange: p.D393fs
exon_skip_286384_HNSC_TCGA-F7-7848-01.png
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exon_skip_344329_HNSC_TCGA-F7-7848-01.png
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exon_skip_421270_HNSC_TCGA-F7-7848-01.png
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exon_skip_456520_HNSC_TCGA-F7-7848-01.png
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check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LOVO_LARGE_INTESTINE1729435173051417303081730308Frame_Shift_DelC-p.D393fs
SKUT1_SOFT_TISSUE1729435173051417303081730308Frame_Shift_DelC-p.D393fs
HCC2450_LUNG1725429172559717254661725466Missense_MutationGTp.Q58H
HCC2450_LUNG1725455172559717254661725466Missense_MutationGTp.Q58H
SNU520_STOMACH1725429172559717255761725576Missense_MutationCTp.P95L
SNU520_STOMACH1725455172559717255761725576Missense_MutationCTp.P95L
SNU1040_LARGE_INTESTINE1725429172559717255761725576Missense_MutationCTp.P95L
SNU1040_LARGE_INTESTINE1725455172559717255761725576Missense_MutationCTp.P95L
DU145_PROSTATE1729435173051417295991729599Missense_MutationCTp.S157F
KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417296441729644Missense_MutationGAp.G172E
LNCAPCLONEFGC_PROSTATE1729435173051417296531729653Missense_MutationCTp.S175F
A375_SKIN1729435173051417296981729698Missense_MutationCTp.S190F
ML1_THYROID1729435173051417297031729703Missense_MutationGAp.D192N
KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417297071729707Missense_MutationGAp.R193K
SBC3_LUNG1729435173051417297071729707Missense_MutationGAp.R193K
SCMCRM2_SOFT_TISSUE1729435173051417297121729712Missense_MutationGAp.V195M
KMRC2_KIDNEY1729435173051417297121729712Missense_MutationGAp.V195M
TC106_BONE1729435173051417297271729727Missense_MutationGAp.E200K
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417299641729964Missense_MutationGAp.V279M
COLO668_LUNG1729435173051417299681729968Missense_MutationGTp.G280V
UMC11_LUNG1729435173051417299941729994Missense_MutationCGp.Q289E
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417300221730022Missense_MutationCTp.A298V
NEC8_TESTIS1729435173051417300401730040Missense_MutationCTp.P304L
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417300491730049Missense_MutationATp.H307L
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417301211730121Missense_MutationCTp.S331L
DOK_UPPER_AERODIGESTIVE_TRACT1729435173051417301321730132Missense_MutationCTp.P335S
OCIMY7_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417302131730213Missense_MutationGAp.G362S
NB69_AUTONOMIC_GANGLIA1729435173051417303171730317Missense_MutationGTp.M396I
GP5D_LARGE_INTESTINE1729435173051417304231730423Missense_MutationCTp.P432S
MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1729435173051417304831730483Missense_MutationGAp.A452T
KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1732899173302817329531732953Missense_MutationGAp.E506K
MEG01_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1732899173302817329531732953Missense_MutationGAp.E506K
LC2AD_LUNG1732899173302817329531732953Missense_MutationGAp.E506K
LC41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1732899173302817329531732953Missense_MutationGAp.E506K
WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1732899173302817329831732983Missense_MutationCTp.P516S
EN_ENDOMETRIUM1732899173302817330131733013Missense_MutationAGp.R526G
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1738968173905517389781738978Missense_MutationGAp.A587T
A388_SKIN1738968173905517389841738984Missense_MutationGAp.E589K
SBC3_LUNG1738968173905517390001739000Missense_MutationGAp.R594H
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1738968173905517390001739000Missense_MutationGAp.R594H
JHOS3_OVARY1738968173905517390121739012Missense_MutationCGp.A598G
NKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1738968173905517390121739012Missense_MutationCGp.A598G
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1742553174271317425751742575Missense_MutationATp.E695D
LS411N_LARGE_INTESTINE1742553174271317426961742696Missense_MutationAGp.I736V
HCT15_LARGE_INTESTINE1725429172559717255421725542Nonsense_MutationCTp.Q84*
HCT15_LARGE_INTESTINE1725455172559717255421725542Nonsense_MutationCTp.Q84*
HRT18_LARGE_INTESTINE1725429172559717255421725542Nonsense_MutationCTp.Q84*
HRT18_LARGE_INTESTINE1725455172559717255421725542Nonsense_MutationCTp.Q84*
CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE1732899173302817330271733027Splice_SiteGTp.E530D

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TACC3

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_42127041725544:1725597:1729434:1730514:1732613:17326891729434:1730514ENST00000484651.1,ENST00000313288.4LUSCrs1063742chr4:1729660C/T1.03e-03
exon_skip_42127041725544:1725597:1729434:1730514:1732613:17326891729434:1730514ENST00000484651.1,ENST00000313288.4LUSCrs17132047chr4:1729953G/A1.69e-03
exon_skip_42127041725544:1725597:1729434:1730514:1732613:17326891729434:1730514ENST00000484651.1,ENST00000313288.4LUSCrs1063743chr4:1729988G/A1.74e-03
exon_skip_42127641732613:1732689:1732898:1733028:1736999:17370521732898:1733028ENST00000484651.1,ENST00000485989.2,ENST00000466077.1,ENST00000313288.4LUSCrs17680881chr4:1732978G/A1.73e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TACC3


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TACC3


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RelatedDrugs for TACC3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TACC3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
TACC3C0005695Bladder Neoplasm1CTD_human
TACC3C0007138Carcinoma, Transitional Cell1CTD_human