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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for YAP1 |
 Gene summary |
| Gene information | Gene symbol | YAP1 | Gene ID | 10413 |
| Gene name | Yes associated protein 1 | |
| Synonyms | COB1|YAP|YAP2|YAP65|YKI | |
| Cytomap | 11q22.1 | |
| Type of gene | protein-coding | |
| Description | transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog | |
| Modification date | 20180527 | |
| UniProtAcc | P46937 | |
| Context | PubMed: YAP1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| YAP1 | GO:0006974 | cellular response to DNA damage stimulus | 18280240 |
| YAP1 | GO:0008283 | cell proliferation | 17974916 |
| YAP1 | GO:0032570 | response to progesterone | 16772533 |
| YAP1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 16772533 |
| YAP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20368466 |
| YAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25796446 |
| YAP1 | GO:0050767 | regulation of neurogenesis | 25433207 |
| YAP1 | GO:0050847 | progesterone receptor signaling pathway | 16772533 |
| YAP1 | GO:0060242 | contact inhibition | 17974916 |
| YAP1 | GO:0065003 | protein-containing complex assembly | 20368466 |
| YAP1 | GO:0071480 | cellular response to gamma radiation | 18280240 |
| YAP1 | GO:0072091 | regulation of stem cell proliferation | 25433207 |
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Exon skipping events across known transcript of Ensembl for YAP1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for YAP1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for YAP1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_64598 | 11 | 102033186:102033302:102056748:102056862:102076623:102076805 | 102056748:102056862 | ENSG00000137693.9 | ENST00000537274.1,ENST00000282441.5,ENST00000524575.1,ENST00000531439.1 |
| exon_skip_64604 | 11 | 102076623:102076805:102080247:102080295:102094352:102094483 | 102080247:102080295 | ENSG00000137693.9 | ENST00000282441.5,ENST00000524575.1 |
| exon_skip_64607 | 11 | 102076623:102076805:102094352:102094483:102098199:102098312 | 102094352:102094483 | ENSG00000137693.9 | ENST00000526343.1,ENST00000531439.1 |
| exon_skip_64610 | 11 | 102076623:102076817:102080247:102080295:102094352:102094483 | 102080247:102080295 | ENSG00000137693.9 | ENST00000529029.1 |
| exon_skip_64614 | 11 | 102080247:102080295:102094352:102094483:102098199:102098312 | 102094352:102094483 | ENSG00000137693.9 | ENST00000529029.1,ENST00000282441.5,ENST00000524575.1 |
| exon_skip_64618 | 11 | 102094352:102094483:102098199:102098312:102100432:102100694 | 102098199:102098312 | ENSG00000137693.9 | ENST00000526343.1,ENST00000537274.1,ENST00000529029.1,ENST00000345877.2,ENST00000282441.5,ENST00000524575.1,ENST00000531439.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for YAP1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_64598 | 11 | 102033186:102033302:102056748:102056862:102076623:102076805 | 102056748:102056862 | ENSG00000137693.9 | ENST00000282441.5,ENST00000537274.1,ENST00000531439.1,ENST00000524575.1 |
| exon_skip_64604 | 11 | 102076623:102076805:102080247:102080295:102094352:102094483 | 102080247:102080295 | ENSG00000137693.9 | ENST00000282441.5,ENST00000524575.1 |
| exon_skip_64607 | 11 | 102076623:102076805:102094352:102094483:102098199:102098312 | 102094352:102094483 | ENSG00000137693.9 | ENST00000526343.1,ENST00000531439.1 |
| exon_skip_64610 | 11 | 102076623:102076817:102080247:102080295:102094352:102094483 | 102080247:102080295 | ENSG00000137693.9 | ENST00000529029.1 |
| exon_skip_64614 | 11 | 102080247:102080295:102094352:102094483:102098199:102098312 | 102094352:102094483 | ENSG00000137693.9 | ENST00000282441.5,ENST00000524575.1,ENST00000529029.1 |
| exon_skip_64618 | 11 | 102094352:102094483:102098199:102098312:102100432:102100694 | 102098199:102098312 | ENSG00000137693.9 | ENST00000526343.1,ENST00000282441.5,ENST00000537274.1,ENST00000345877.2,ENST00000531439.1,ENST00000524575.1,ENST00000529029.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for YAP1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000282441 | 102094352 | 102094483 | Frame-shift |
| ENST00000282441 | 102098199 | 102098312 | Frame-shift |
| ENST00000282441 | 102056748 | 102056862 | In-frame |
| ENST00000282441 | 102080247 | 102080295 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000282441 | 102094352 | 102094483 | Frame-shift |
| ENST00000282441 | 102098199 | 102098312 | Frame-shift |
| ENST00000282441 | 102056748 | 102056862 | In-frame |
| ENST00000282441 | 102080247 | 102080295 | In-frame |
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Infer the effects of exon skipping event on protein functional features for YAP1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000282441 | 5403 | 504 | 102056748 | 102056862 | 1077 | 1190 | 229 | 267 |
| ENST00000282441 | 5403 | 504 | 102080247 | 102080295 | 1373 | 1420 | 328 | 344 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000282441 | 5403 | 504 | 102056748 | 102056862 | 1077 | 1190 | 229 | 267 |
| ENST00000282441 | 5403 | 504 | 102080247 | 102080295 | 1373 | 1420 | 328 | 344 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for YAP1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_64607 exon_skip_64614 | 102094353 | 102094483 | 102094405 | 102094405 | Frame_Shift_Del | A | - | p.Q362fs |
| BLCA | TCGA-FD-A3SO-01 | 102098200 | 102098312 | 102098267 | 102098267 | Nonsense_Mutation | C | T | p.R411* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102056749 | 102056862 | 102056754 | 102056754 | Missense_Mutation | C | T | p.L232F |
| HCT15_LARGE_INTESTINE | 102056749 | 102056862 | 102056796 | 102056796 | Missense_Mutation | A | T | p.I246F |
| LUDLU1_LUNG | 102056749 | 102056862 | 102056805 | 102056805 | Missense_Mutation | A | G | p.I249V |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 102080248 | 102080295 | 102080253 | 102080253 | Missense_Mutation | G | A | p.M330I |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102080248 | 102080295 | 102080253 | 102080253 | Missense_Mutation | G | A | p.M330I |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102080248 | 102080295 | 102080253 | 102080253 | Missense_Mutation | G | A | p.M330I |
| S117_SOFT_TISSUE | 102080248 | 102080295 | 102080253 | 102080253 | Missense_Mutation | G | A | p.M330I |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 102080248 | 102080295 | 102080281 | 102080281 | Missense_Mutation | T | G | p.S340A |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 102080248 | 102080295 | 102080281 | 102080281 | Missense_Mutation | T | G | p.S340A |
| S117_SOFT_TISSUE | 102080248 | 102080295 | 102080281 | 102080281 | Missense_Mutation | T | G | p.S340A |
| EPLC272H_LUNG | 102094353 | 102094483 | 102094388 | 102094388 | Missense_Mutation | G | T | p.E356D |
| WM793_SKIN | 102094353 | 102094483 | 102094390 | 102094390 | Missense_Mutation | A | C | p.Q357P |
| NCIH2023_LUNG | 102094353 | 102094483 | 102094451 | 102094451 | Missense_Mutation | G | T | p.M377I |
| HCC1599_BREAST | 102094353 | 102094483 | 102094468 | 102094468 | Missense_Mutation | A | C | p.D383A |
| U138MG_CENTRAL_NERVOUS_SYSTEM | 102098200 | 102098312 | 102098297 | 102098297 | Missense_Mutation | G | A | p.D421N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for YAP1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YAP1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YAP1 |
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RelatedDrugs for YAP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YAP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| YAP1 | C0027819 | Neuroblastoma | 1 | CTD_human |
| YAP1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| YAP1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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