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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FSTL3 |
 Gene summary |
| Gene information | Gene symbol | FSTL3 | Gene ID | 10272 |
| Gene name | follistatin like 3 | |
| Synonyms | FLRG|FSRP | |
| Cytomap | 19p13.3 | |
| Type of gene | protein-coding | |
| Description | follistatin-related protein 3follistatin-like 3 (secreted glycoprotein)follistatin-like protein 3follistatin-related gene protein | |
| Modification date | 20180519 | |
| UniProtAcc | O95633 | |
| Context | PubMed: FSTL3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FSTL3 | GO:0002244 | hematopoietic progenitor cell differentiation | 15451575 |
| FSTL3 | GO:0006357 | regulation of transcription by RNA polymerase II | 11948405 |
| FSTL3 | GO:0022409 | positive regulation of cell-cell adhesion | 16336961 |
| FSTL3 | GO:0030514 | negative regulation of BMP signaling pathway | 17878677 |
| FSTL3 | GO:0032926 | negative regulation of activin receptor signaling pathway | 11948405|12697670 |
| FSTL3 | GO:0045671 | negative regulation of osteoclast differentiation | 15574124 |
| FSTL3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17868029 |
| FSTL3 | GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 17878677 |
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Exon skipping events across known transcript of Ensembl for FSTL3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FSTL3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FSTL3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_300204 | 19 | 677941:677977:680273:680489:681332:681560 | 680273:680489 | ENSG00000070404.5 | ENST00000166139.4,ENST00000591552.2 |
| exon_skip_300205 | 19 | 680273:680489:681332:681560:681649:681673 | 681332:681560 | ENSG00000070404.5 | ENST00000588773.1,ENST00000166139.4,ENST00000591552.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FSTL3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_300204 | 19 | 677941:677977:680273:680489:681332:681560 | 680273:680489 | ENSG00000070404.5 | ENST00000166139.4,ENST00000591552.2 |
| exon_skip_300205 | 19 | 680273:680489:681332:681560:681649:681673 | 681332:681560 | ENSG00000070404.5 | ENST00000166139.4,ENST00000591552.2,ENST00000588773.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FSTL3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000166139 | 680273 | 680489 | In-frame |
| ENST00000166139 | 681332 | 681560 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000166139 | 680273 | 680489 | In-frame |
| ENST00000166139 | 681332 | 681560 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FSTL3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000166139 | 2518 | 263 | 680273 | 680489 | 322 | 537 | 96 | 168 |
| ENST00000166139 | 2518 | 263 | 681332 | 681560 | 538 | 765 | 168 | 244 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000166139 | 2518 | 263 | 680273 | 680489 | 322 | 537 | 96 | 168 |
| ENST00000166139 | 2518 | 263 | 681332 | 681560 | 538 | 765 | 168 | 244 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95633 | 96 | 168 | 97 | 99 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 108 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 113 | 116 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B4V |
| O95633 | 96 | 168 | 118 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 126 | 128 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 134 | 136 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 141 | 144 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 161 | 166 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 27 | 263 | Chain | ID=PRO_0000010115;Note=Follistatin-related protein 3 |
| O95633 | 96 | 168 | 99 | 110 | Disulfide bond | . |
| O95633 | 96 | 168 | 104 | 119 | Disulfide bond | . |
| O95633 | 96 | 168 | 121 | 153 | Disulfide bond | . |
| O95633 | 96 | 168 | 125 | 146 | Disulfide bond | . |
| O95633 | 96 | 168 | 135 | 167 | Disulfide bond | . |
| O95633 | 96 | 168 | 36 | 107 | Domain | Note=TB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697 |
| O95633 | 96 | 168 | 99 | 119 | Domain | Note=Follistatin-like 1 |
| O95633 | 96 | 168 | 113 | 169 | Domain | Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
| O95633 | 96 | 168 | 145 | 153 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 169 | 171 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 181 | 184 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 190 | 193 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 204 | 207 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 210 | 212 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 217 | 220 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 237 | 241 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 27 | 263 | Chain | ID=PRO_0000010115;Note=Follistatin-related protein 3 |
| O95633 | 168 | 244 | 171 | 182 | Disulfide bond | . |
| O95633 | 168 | 244 | 176 | 192 | Disulfide bond | . |
| O95633 | 168 | 244 | 195 | 229 | Disulfide bond | . |
| O95633 | 168 | 244 | 200 | 222 | Disulfide bond | . |
| O95633 | 168 | 244 | 211 | 243 | Disulfide bond | . |
| O95633 | 168 | 244 | 113 | 169 | Domain | Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
| O95633 | 168 | 244 | 170 | 193 | Domain | Note=Follistatin-like 2 |
| O95633 | 168 | 244 | 189 | 245 | Domain | Note=Kazal-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
| O95633 | 168 | 244 | 215 | 215 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18768470;Dbxref=PMID:18768470 |
| O95633 | 168 | 244 | 221 | 231 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95633 | 96 | 168 | 97 | 99 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 108 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 113 | 116 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3B4V |
| O95633 | 96 | 168 | 118 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 126 | 128 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 134 | 136 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 141 | 144 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 161 | 166 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 96 | 168 | 27 | 263 | Chain | ID=PRO_0000010115;Note=Follistatin-related protein 3 |
| O95633 | 96 | 168 | 99 | 110 | Disulfide bond | . |
| O95633 | 96 | 168 | 104 | 119 | Disulfide bond | . |
| O95633 | 96 | 168 | 121 | 153 | Disulfide bond | . |
| O95633 | 96 | 168 | 125 | 146 | Disulfide bond | . |
| O95633 | 96 | 168 | 135 | 167 | Disulfide bond | . |
| O95633 | 96 | 168 | 36 | 107 | Domain | Note=TB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00697 |
| O95633 | 96 | 168 | 99 | 119 | Domain | Note=Follistatin-like 1 |
| O95633 | 96 | 168 | 113 | 169 | Domain | Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
| O95633 | 96 | 168 | 145 | 153 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 169 | 171 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 181 | 184 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 190 | 193 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 204 | 207 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 210 | 212 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 217 | 220 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 237 | 241 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
| O95633 | 168 | 244 | 27 | 263 | Chain | ID=PRO_0000010115;Note=Follistatin-related protein 3 |
| O95633 | 168 | 244 | 171 | 182 | Disulfide bond | . |
| O95633 | 168 | 244 | 176 | 192 | Disulfide bond | . |
| O95633 | 168 | 244 | 195 | 229 | Disulfide bond | . |
| O95633 | 168 | 244 | 200 | 222 | Disulfide bond | . |
| O95633 | 168 | 244 | 211 | 243 | Disulfide bond | . |
| O95633 | 168 | 244 | 113 | 169 | Domain | Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
| O95633 | 168 | 244 | 170 | 193 | Domain | Note=Follistatin-like 2 |
| O95633 | 168 | 244 | 189 | 245 | Domain | Note=Kazal-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
| O95633 | 168 | 244 | 215 | 215 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18768470;Dbxref=PMID:18768470 |
| O95633 | 168 | 244 | 221 | 231 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
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SNVs in the skipped exons for FSTL3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CESC | TCGA-JW-A5VL-01 | exon_skip_300205 | 681333 | 681560 | 681413 | 681413 | Nonsense_Mutation | C | T | p.R196* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 680274 | 680489 | 680345 | 680345 | Missense_Mutation | T | A | p.C121S |
| LMSU_STOMACH | 680274 | 680489 | 680419 | 680419 | Missense_Mutation | G | C | p.E145D |
| UACC812_BREAST | 680274 | 680489 | 680474 | 680474 | Missense_Mutation | C | G | p.R164G |
| EN_ENDOMETRIUM | 681333 | 681560 | 681345 | 681345 | Missense_Mutation | A | G | p.H173R |
| SNU1040_LARGE_INTESTINE | 681333 | 681560 | 681489 | 681489 | Missense_Mutation | C | T | p.S221L |
| HEC1_ENDOMETRIUM | 681333 | 681560 | 681539 | 681539 | Missense_Mutation | C | T | p.R238C |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FSTL3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FSTL3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FSTL3 |
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RelatedDrugs for FSTL3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FSTL3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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