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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TOB1 |
 Gene summary |
| Gene information | Gene symbol | TOB1 | Gene ID | 10140 |
| Gene name | transducer of ERBB2, 1 | |
| Synonyms | APRO5|APRO6|PIG49|TOB|TROB|TROB1 | |
| Cytomap | 17q21.33 | |
| Type of gene | protein-coding | |
| Description | protein Tob1proliferation-inducing gene 49transducer of erbB-2 1 | |
| Modification date | 20180523 | |
| UniProtAcc | P50616 | |
| Context | PubMed: TOB1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TOB1 | GO:0008285 | negative regulation of cell proliferation | 8632892|19276069 |
| TOB1 | GO:0017148 | negative regulation of translation | 23236473 |
| TOB1 | GO:0060212 | negative regulation of nuclear-transcribed mRNA poly(A) tail shortening | 18377426 |
| TOB1 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 21336257 |
| TOB1 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 21336257 |
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Exon skipping events across known transcript of Ensembl for TOB1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TOB1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TOB1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_291500 | 17 | 48940340:48941524:48944854:48944963:48945165:48945339 | 48944854:48944963 | ENSG00000141232.4 | ENST00000268957.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TOB1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_291500 | 17 | 48940340:48941524:48944854:48944963:48945165:48945339 | 48944854:48944963 | ENSG00000141232.4 | ENST00000268957.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TOB1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000268957 | 48944854 | 48944963 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000268957 | 48944854 | 48944963 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for TOB1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TOB1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TOB1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TOB1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TOB1 |
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RelatedDrugs for TOB1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TOB1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TOB1 | C0014175 | Endometriosis | 1 | CTD_human |
| TOB1 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| TOB1 | C0263454 | Chloracne | 1 | CTD_human |
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