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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PTPRU |
 Gene summary |
| Gene information | Gene symbol | PTPRU | Gene ID | 10076 |
| Gene name | protein tyrosine phosphatase, receptor type U | |
| Synonyms | FMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-J | |
| Cytomap | 1p35.3 | |
| Type of gene | protein-coding | |
| Description | receptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronr | |
| Modification date | 20180522 | |
| UniProtAcc | Q92729 | |
| Context | PubMed: PTPRU [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PTPRU | GO:0006470 | protein dephosphorylation | 12501215 |
| PTPRU | GO:0008285 | negative regulation of cell proliferation | 16574648 |
| PTPRU | GO:0030336 | negative regulation of cell migration | 12501215|16574648 |
| PTPRU | GO:0034394 | protein localization to cell surface | 16574648 |
| PTPRU | GO:0060070 | canonical Wnt signaling pathway | 16574648 |
| PTPRU | GO:0098609 | cell-cell adhesion | 16574648 |
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Exon skipping events across known transcript of Ensembl for PTPRU from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PTPRU |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PTPRU |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_3543 | 1 | 29585772:29585854:29585960:29586076:29586381:29586556 | 29585960:29586076 | ENSG00000060656.15 | ENST00000323874.8,ENST00000460170.2,ENST00000345512.3,ENST00000373779.3,ENST00000428026.2,ENST00000356870.3 |
| exon_skip_3544 | 1 | 29587121:29587415:29601959:29602268:29605523:29605633 | 29601959:29602268 | ENSG00000060656.15 | ENST00000323874.8,ENST00000460170.2,ENST00000345512.3,ENST00000373779.3,ENST00000428026.2,ENST00000356870.3 |
| exon_skip_3545 | 1 | 29601959:29602268:29605523:29605633:29605967:29606169 | 29605523:29605633 | ENSG00000060656.15 | ENST00000323874.8,ENST00000460170.2,ENST00000345512.3,ENST00000373779.3,ENST00000428026.2,ENST00000356870.3 |
| exon_skip_3548 | 1 | 29609187:29609461:29610451:29610488:29611242:29611381 | 29610451:29610488 | ENSG00000060656.15 | ENST00000323874.8,ENST00000415600.2,ENST00000460170.2,ENST00000345512.3,ENST00000373779.3,ENST00000428026.2,ENST00000356870.3 |
| exon_skip_3549 | 1 | 29610451:29610488:29611242:29611381:29618380:29618538 | 29611242:29611381 | ENSG00000060656.15 | ENST00000323874.8,ENST00000460170.2,ENST00000373779.3,ENST00000428026.2,ENST00000531385.1,ENST00000356870.3 |
| exon_skip_3550 | 1 | 29611242:29611381:29616194:29616224:29618380:29618538 | 29616194:29616224 | ENSG00000060656.15 | ENST00000415600.2,ENST00000345512.3 |
| exon_skip_3553 | 1 | 29631863:29631940:29633640:29633658:29637255:29637292 | 29633640:29633658 | ENSG00000060656.15 | ENST00000460170.2,ENST00000356870.3 |
| exon_skip_3554 | 1 | 29631863:29631940:29637255:29637292:29637967:29638056 | 29637255:29637292 | ENSG00000060656.15 | ENST00000415600.2,ENST00000345512.3,ENST00000373779.3,ENST00000428026.2 |
| exon_skip_3558 | 1 | 29637255:29637292:29637967:29638056:29638154:29638271 | 29637967:29638056 | ENSG00000060656.15 | ENST00000415600.2,ENST00000428026.2 |
| exon_skip_3559 | 1 | 29637255:29637292:29637967:29638065:29638154:29638271 | 29637967:29638065 | ENSG00000060656.15 | ENST00000323874.8,ENST00000460170.2,ENST00000345512.3,ENST00000373779.3,ENST00000356870.3 |
| exon_skip_3563 | 1 | 29644271:29644433:29647196:29647337:29649882:29650008 | 29647196:29647337 | ENSG00000060656.15 | ENST00000323874.8,ENST00000460170.2,ENST00000493601.1,ENST00000345512.3,ENST00000373779.3,ENST00000428026.2,ENST00000356870.3 |
| exon_skip_3565 | 1 | 29647196:29647337:29649882:29650008:29650148:29650300 | 29649882:29650008 | ENSG00000060656.15 | ENST00000460170.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PTPRU |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_3543 | 1 | 29585772:29585854:29585960:29586076:29586381:29586556 | 29585960:29586076 | ENSG00000060656.15 | ENST00000345512.3,ENST00000373779.3,ENST00000356870.3,ENST00000323874.8,ENST00000428026.2,ENST00000460170.2 |
| exon_skip_3544 | 1 | 29587121:29587415:29601959:29602268:29605523:29605633 | 29601959:29602268 | ENSG00000060656.15 | ENST00000345512.3,ENST00000373779.3,ENST00000356870.3,ENST00000323874.8,ENST00000428026.2,ENST00000460170.2 |
| exon_skip_3545 | 1 | 29601959:29602268:29605523:29605633:29605967:29606169 | 29605523:29605633 | ENSG00000060656.15 | ENST00000345512.3,ENST00000373779.3,ENST00000356870.3,ENST00000323874.8,ENST00000428026.2,ENST00000460170.2 |
| exon_skip_3548 | 1 | 29609187:29609461:29610451:29610488:29611242:29611381 | 29610451:29610488 | ENSG00000060656.15 | ENST00000345512.3,ENST00000373779.3,ENST00000356870.3,ENST00000323874.8,ENST00000428026.2,ENST00000460170.2,ENST00000415600.2 |
| exon_skip_3549 | 1 | 29610451:29610488:29611242:29611381:29618380:29618538 | 29611242:29611381 | ENSG00000060656.15 | ENST00000373779.3,ENST00000356870.3,ENST00000323874.8,ENST00000428026.2,ENST00000460170.2,ENST00000531385.1 |
| exon_skip_3550 | 1 | 29611242:29611381:29616194:29616224:29618380:29618538 | 29616194:29616224 | ENSG00000060656.15 | ENST00000345512.3,ENST00000415600.2 |
| exon_skip_3553 | 1 | 29631863:29631940:29633640:29633658:29637255:29637292 | 29633640:29633658 | ENSG00000060656.15 | ENST00000356870.3,ENST00000460170.2 |
| exon_skip_3554 | 1 | 29631863:29631940:29637255:29637292:29637967:29638056 | 29637255:29637292 | ENSG00000060656.15 | ENST00000345512.3,ENST00000373779.3,ENST00000428026.2,ENST00000415600.2 |
| exon_skip_3563 | 1 | 29644271:29644433:29647196:29647337:29649882:29650008 | 29647196:29647337 | ENSG00000060656.15 | ENST00000345512.3,ENST00000373779.3,ENST00000356870.3,ENST00000323874.8,ENST00000428026.2,ENST00000460170.2,ENST00000493601.1 |
| exon_skip_3565 | 1 | 29647196:29647337:29649882:29650008:29650148:29650300 | 29649882:29650008 | ENSG00000060656.15 | ENST00000460170.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PTPRU |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000345512 | 29585960 | 29586076 | Frame-shift |
| ENST00000345512 | 29605523 | 29605633 | Frame-shift |
| ENST00000345512 | 29610451 | 29610488 | Frame-shift |
| ENST00000345512 | 29637255 | 29637292 | Frame-shift |
| ENST00000345512 | 29637967 | 29638065 | Frame-shift |
| ENST00000345512 | 29601959 | 29602268 | In-frame |
| ENST00000345512 | 29616194 | 29616224 | In-frame |
| ENST00000345512 | 29647196 | 29647337 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000345512 | 29585960 | 29586076 | Frame-shift |
| ENST00000345512 | 29605523 | 29605633 | Frame-shift |
| ENST00000345512 | 29610451 | 29610488 | Frame-shift |
| ENST00000345512 | 29637255 | 29637292 | Frame-shift |
| ENST00000345512 | 29601959 | 29602268 | In-frame |
| ENST00000345512 | 29616194 | 29616224 | In-frame |
| ENST00000345512 | 29647196 | 29647337 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PTPRU |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000345512 | 4487 | 1446 | 29601959 | 29602268 | 1274 | 1582 | 381 | 484 |
| ENST00000345512 | 4487 | 1446 | 29616194 | 29616224 | 2448 | 2477 | 773 | 782 |
| ENST00000345512 | 4487 | 1446 | 29647196 | 29647337 | 3847 | 3987 | 1239 | 1286 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000345512 | 4487 | 1446 | 29601959 | 29602268 | 1274 | 1582 | 381 | 484 |
| ENST00000345512 | 4487 | 1446 | 29616194 | 29616224 | 2448 | 2477 | 773 | 782 |
| ENST00000345512 | 4487 | 1446 | 29647196 | 29647337 | 3847 | 3987 | 1239 | 1286 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PTPRU |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_3543 | 29585961 | 29586076 | 29586051 | 29586051 | Frame_Shift_Del | C | - | p.A217fs |
| HNSC | TCGA-CR-7364-01 | exon_skip_3549 | 29611243 | 29611381 | 29611279 | 29611279 | Frame_Shift_Del | C | - | p.S739fs |
| THCA | TCGA-FY-A3NN-01 | exon_skip_3543 | 29585961 | 29586076 | 29586031 | 29586031 | Nonsense_Mutation | C | A | p.C210* |
| STAD | TCGA-BR-6452-01 | exon_skip_3549 | 29611243 | 29611381 | 29611288 | 29611288 | Nonsense_Mutation | C | A | p.S742* |
| STAD | TCGA-BR-6452-01 | exon_skip_3549 | 29611243 | 29611381 | 29611288 | 29611288 | Nonsense_Mutation | C | A | p.S742X |
| UCEC | TCGA-A5-A0G9-01 | exon_skip_3565 | 29649883 | 29650008 | 29649897 | 29649897 | Nonsense_Mutation | C | A | p.Y1291* |
| UCEC | TCGA-D1-A103-01 | exon_skip_3553 | 29633641 | 29633658 | 29633659 | 29633659 | Splice_Site | G | A | e19+1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-D1-A103-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_3553 | |
| Skipped exon start: 29633641 | |
| Skipped exon end: 29633658 | |
| Mutation start: 29633659 | |
| Mutation end: 29633659 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: e19+1 | |
exon_skip_101712_UCEC_TCGA-D1-A103-01.png | |
exon_skip_140352_UCEC_TCGA-D1-A103-01.png | |
exon_skip_347979_UCEC_TCGA-D1-A103-01.png | |
exon_skip_347981_UCEC_TCGA-D1-A103-01.png | |
exon_skip_3553_UCEC_TCGA-D1-A103-01.png | |
exon_skip_387613_UCEC_TCGA-D1-A103-01.png | |
exon_skip_421138_UCEC_TCGA-D1-A103-01.png | |
exon_skip_421147_UCEC_TCGA-D1-A103-01.png | |
exon_skip_66022_UCEC_TCGA-D1-A103-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 29585961 | 29586076 | 29585978 | 29585979 | Frame_Shift_Ins | - | C | p.S193fs |
| RKO_LARGE_INTESTINE | 29585961 | 29586076 | 29586024 | 29586024 | Missense_Mutation | T | C | p.F208S |
| SNU349_KIDNEY | 29585961 | 29586076 | 29586048 | 29586048 | Missense_Mutation | C | T | p.A216V |
| SKNSH_AUTONOMIC_GANGLIA | 29605524 | 29605633 | 29605623 | 29605623 | Missense_Mutation | C | T | p.T518I |
| HEC1A_ENDOMETRIUM | 29610452 | 29610488 | 29610473 | 29610473 | Missense_Mutation | C | T | p.R722C |
| HEC1_ENDOMETRIUM | 29610452 | 29610488 | 29610473 | 29610473 | Missense_Mutation | C | T | p.R722C |
| HEC1B_ENDOMETRIUM | 29610452 | 29610488 | 29610473 | 29610473 | Missense_Mutation | C | T | p.R722C |
| SNU324_PANCREAS | 29610452 | 29610488 | 29610474 | 29610474 | Missense_Mutation | G | A | p.R722H |
| OVKATE_OVARY | 29611243 | 29611381 | 29611266 | 29611266 | Missense_Mutation | C | G | p.P735A |
| SW48_LARGE_INTESTINE | 29611243 | 29611381 | 29611356 | 29611356 | Missense_Mutation | G | T | p.A765S |
| SNU175_LARGE_INTESTINE | 29611243 | 29611381 | 29611375 | 29611375 | Missense_Mutation | G | A | p.R771H |
| NCIH2081_LUNG | 29616195 | 29616224 | 29616206 | 29616206 | Missense_Mutation | A | G | p.Y777C |
| PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 29616195 | 29616224 | 29616211 | 29616211 | Missense_Mutation | T | C | p.Y779H |
| SW1116_LARGE_INTESTINE | 29637256 | 29637292 | 29637287 | 29637287 | Missense_Mutation | C | A | p.T961N |
| HEC108_ENDOMETRIUM | 29647197 | 29647337 | 29647206 | 29647206 | Missense_Mutation | C | T | p.R1243W |
| HEC108_ENDOMETRIUM | 29649883 | 29650008 | 29649932 | 29649932 | Missense_Mutation | T | C | p.M1303T |
| DMS79_LUNG | 29601960 | 29602268 | 29602139 | 29602139 | Nonsense_Mutation | G | T | p.E442* |
| NCIH2342_LUNG | 29601960 | 29602268 | 29602142 | 29602142 | Nonsense_Mutation | C | T | p.Q443* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTPRU |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PTPRU |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PTPRU |
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RelatedDrugs for PTPRU |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPRU |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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