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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RANBP9 |
 Gene summary |
| Gene information | Gene symbol | RANBP9 | Gene ID | 10048 |
| Gene name | RAN binding protein 9 | |
| Synonyms | BPM-L|BPM90|RANBPM|RanBP7 | |
| Cytomap | 6p23 | |
| Type of gene | protein-coding | |
| Description | ran-binding protein 9Ran Binding Protein in the Microtubule organizing centernovel centrosomal protein RanBPMran binding protein, centrosomalran-binding protein M | |
| Modification date | 20180522 | |
| UniProtAcc | Q96S59 | |
| Context | PubMed: RANBP9 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RANBP9 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RANBP9 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RANBP9 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_456316 | 6 | 13632601:13632753:13634662:13634784:13638039:13638187 | 13634662:13634784 | ENSG00000010017.9 | ENST00000539980.1,ENST00000011619.3 |
| exon_skip_456318 | 6 | 13641430:13641539:13642710:13642823:13644776:13644961 | 13642710:13642823 | ENSG00000010017.9 | ENST00000539980.1,ENST00000011619.3 |
| exon_skip_456322 | 6 | 13642710:13642823:13644776:13644961:13652890:13652913 | 13644776:13644961 | ENSG00000010017.9 | ENST00000539980.1,ENST00000011619.3 |
| exon_skip_456324 | 6 | 13644776:13644961:13652890:13652913:13657340:13657508 | 13652890:13652913 | ENSG00000010017.9 | ENST00000539980.1,ENST00000011619.3 |
| exon_skip_456327 | 6 | 13652890:13652913:13657340:13657508:13659011:13659064 | 13657340:13657508 | ENSG00000010017.9 | ENST00000539980.1,ENST00000011619.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RANBP9 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_456316 | 6 | 13632601:13632753:13634662:13634784:13638039:13638187 | 13634662:13634784 | ENSG00000010017.9 | ENST00000011619.3,ENST00000539980.1 |
| exon_skip_456318 | 6 | 13641430:13641539:13642710:13642823:13644776:13644961 | 13642710:13642823 | ENSG00000010017.9 | ENST00000011619.3,ENST00000539980.1 |
| exon_skip_456322 | 6 | 13642710:13642823:13644776:13644961:13652890:13652913 | 13644776:13644961 | ENSG00000010017.9 | ENST00000011619.3,ENST00000539980.1 |
| exon_skip_456324 | 6 | 13644776:13644961:13652890:13652913:13657340:13657508 | 13652890:13652913 | ENSG00000010017.9 | ENST00000011619.3,ENST00000539980.1 |
| exon_skip_456327 | 6 | 13652890:13652913:13657340:13657508:13659011:13659064 | 13657340:13657508 | ENSG00000010017.9 | ENST00000011619.3,ENST00000539980.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RANBP9 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000011619 | 13634662 | 13634784 | Frame-shift |
| ENST00000011619 | 13642710 | 13642823 | Frame-shift |
| ENST00000011619 | 13644776 | 13644961 | Frame-shift |
| ENST00000011619 | 13652890 | 13652913 | Frame-shift |
| ENST00000011619 | 13657340 | 13657508 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000011619 | 13634662 | 13634784 | Frame-shift |
| ENST00000011619 | 13642710 | 13642823 | Frame-shift |
| ENST00000011619 | 13644776 | 13644961 | Frame-shift |
| ENST00000011619 | 13652890 | 13652913 | Frame-shift |
| ENST00000011619 | 13657340 | 13657508 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RANBP9 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000011619 | 3130 | 729 | 13657340 | 13657508 | 796 | 963 | 245 | 301 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000011619 | 3130 | 729 | 13657340 | 13657508 | 796 | 963 | 245 | 301 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96S59 | 245 | 301 | 1 | 341 | Alternative sequence | ID=VSP_013175;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q96S59 | 245 | 301 | 251 | 255 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 260 | 263 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 280 | 286 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 291 | 296 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 299 | 305 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 1 | 729 | Chain | ID=PRO_0000097169;Note=Ran-binding protein 9 |
| Q96S59 | 245 | 301 | 147 | 334 | Domain | Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548 |
| Q96S59 | 245 | 301 | 256 | 258 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 287 | 290 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96S59 | 245 | 301 | 1 | 341 | Alternative sequence | ID=VSP_013175;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q96S59 | 245 | 301 | 251 | 255 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 260 | 263 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 280 | 286 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 291 | 296 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 299 | 305 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 1 | 729 | Chain | ID=PRO_0000097169;Note=Ran-binding protein 9 |
| Q96S59 | 245 | 301 | 147 | 334 | Domain | Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548 |
| Q96S59 | 245 | 301 | 256 | 258 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
| Q96S59 | 245 | 301 | 287 | 290 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JI7 |
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SNVs in the skipped exons for RANBP9 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_456316 | 13634663 | 13634784 | 13634713 | 13634713 | Frame_Shift_Del | T | - | p.N582fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_456322 | 13644777 | 13644961 | 13644797 | 13644797 | Frame_Shift_Del | T | - | p.E364fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_456322 | 13644777 | 13644961 | 13644931 | 13644931 | Frame_Shift_Del | T | - | p.T320fs |
| UCEC | TCGA-AX-A0J0-01 | exon_skip_456318 | 13642711 | 13642823 | 13642738 | 13642738 | Nonsense_Mutation | C | A | p.E400* |
| SKCM | TCGA-W3-AA1V-06 | exon_skip_456322 | 13644777 | 13644961 | 13644826 | 13644826 | Nonsense_Mutation | G | A | p.R355* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| EN_ENDOMETRIUM | 13634663 | 13634784 | 13634708 | 13634708 | Missense_Mutation | T | C | p.S584G |
| NCIH446_LUNG | 13634663 | 13634784 | 13634722 | 13634722 | Missense_Mutation | C | T | p.G579D |
| MYLA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 13634663 | 13634784 | 13634725 | 13634725 | Missense_Mutation | T | C | p.N578S |
| CAPAN2_PANCREAS | 13634663 | 13634784 | 13634725 | 13634725 | Missense_Mutation | T | C | p.N578S |
| M1203273_SKIN | 13634663 | 13634784 | 13634725 | 13634725 | Missense_Mutation | T | C | p.N578S |
| EN_ENDOMETRIUM | 13642711 | 13642823 | 13642774 | 13642774 | Missense_Mutation | C | T | p.A388T |
| HCT15_LARGE_INTESTINE | 13644777 | 13644961 | 13644814 | 13644814 | Missense_Mutation | C | T | p.G359R |
| HRT18_LARGE_INTESTINE | 13644777 | 13644961 | 13644814 | 13644814 | Missense_Mutation | C | T | p.G359R |
| HEKTE_KIDNEY | 13644777 | 13644961 | 13644858 | 13644858 | Missense_Mutation | T | G | p.E344A |
| HEC151_ENDOMETRIUM | 13644777 | 13644961 | 13644862 | 13644862 | Missense_Mutation | G | A | p.R343W |
| NCIH2342_LUNG | 13644777 | 13644961 | 13644880 | 13644880 | Missense_Mutation | C | G | p.D337H |
| SW1417_LARGE_INTESTINE | 13644777 | 13644961 | 13644885 | 13644885 | Missense_Mutation | A | G | p.V335A |
| PATU8902_PANCREAS | 13644777 | 13644961 | 13644898 | 13644898 | Missense_Mutation | G | T | p.Q331K |
| EB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 13644777 | 13644961 | 13644921 | 13644921 | Missense_Mutation | T | C | p.E323G |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 13657341 | 13657508 | 13657365 | 13657365 | Missense_Mutation | A | G | p.Y294H |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 13657341 | 13657508 | 13657365 | 13657365 | Missense_Mutation | A | G | p.Y294H |
| HCC2998_LARGE_INTESTINE | 13642711 | 13642823 | 13642738 | 13642738 | Nonsense_Mutation | C | A | p.E400* |
| SBC5_LUNG | 13657341 | 13657508 | 13657363 | 13657363 | Nonsense_Mutation | G | T | p.Y294* |
| NCIH1734_LUNG | 13634663 | 13634784 | 13634663 | 13634663 | Splice_Site | C | A | p.E599* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RANBP9 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RANBP9 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RANBP9 |
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RelatedDrugs for RANBP9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANBP9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RANBP9 | C0036341 | Schizophrenia | 1 | PSYGENET |
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