label	pval	fdr	signature	geneset	overlap	background	hits	Cell_type	dataset_subgroup	Dataset	Timepoint	primary_key
Unusual Activation of Pro-survival Pathway	1.2e-07	5.9e-07	303	781	30	23467	AREG,AURKA,CERS2,IGF1R,ISG15,MUC1,SOX9,NET1,HSPA5,HSP90B1,FN1,FIS1,FTL,G6PD,HSPB1,PABPC1,PIAS3,PSMB5,NRAS,SEC23A,SRI,SRSF2,TPT1,TOP1,UCP2,GNAS,NPM1,IDI1,SQLE,CREBZF	Malignant cells	GSE104987	GSE104987	NA	1
Irregularity in Drug Uptake and Drug Efflux	0.38	0.88	303	37	1	23467	SLC7A5	Malignant cells	GSE104987	GSE104987	NA	2
Aberration of the Drug's Therapeutic Target	0.69	0.88	303	90	1	23467	NPM1	Malignant cells	GSE104987	GSE104987	NA	3
Epigenetic Alteration of DNA, RNA or Protein	0.7	0.88	303	455	5	23467	IGF1R,TRIP6,TIMP1,MALAT1,H19	Malignant cells	GSE104987	GSE104987	NA	4
Drug Inactivation by Structure Modification	1	1	303	27	0	23467		Malignant cells	GSE104987	GSE104987	NA	5
Unusual Activation of Pro-survival Pathway	3e-18	1.5e-17	2772	781	177	23467	PPP2R5A,ADAM10,AKAP1,AKT2,ANXA2,AURKA,BECN1,BRCA1,CDK4,CERS2,CTNNB1,DNMT1,DUSP6,EPAS1,GLS,GSK3B,GSTP1,SLC2A1,HEY1,HIF1A,HMGA2,HMGB1,EIF4G1,ISG15,JUN,PKM,RPS6KA5,MAGEA12,MCL1,MEF2D,MAPK1,MAP1LC3B,MTOR,NFE2L2,NFKB1,PARP1,PEA15,PPARG,RALBP1,RPS6,SFRP1,SHC1,ST3GAL4,SOX4,SPRY2,TGFB1,TIMP3,PBK,TYMS,XIAP,YWHAZ,AIFM1,AKAP12,TFAP2A,ATG3,ATM,BAG1,HSPA5,BRD4,BTG1,CCNA2,CCND1,CDC27,CDK2,CDKN2A,CDS2,HSPD1,CLTC,CAPNS1,CUL4A,DCK,DDB1,E2F6,EIF3A,ERCC1,ERRFI1,EZH2,EZR,FGFR1,FN1,FOXM1,FTL,FUS,GAPDH,G6PD,GRB2,GCLM,GSR,SLC16A3,HAX1,HDAC1,HDAC3,HMGB2,HNRNPU,HSPA8,HK1,HK2,EIF4A1,EIF5A2,ITGB1,KEAP1,LAMP2,LATS2,LDHA,LRRFIP1,MTDH,MXD4,MAGEA3,NF2,MGMT,MITF,MOB1A,NDST1,IKBKG,NOTCH2,NQO1,PGK1,PIK3CD,AGPAT2,POMP,PSMB5,PSMG2,PTPN1,PTPN12,PTPN18,RAP1A,RAP1B,NRAS,RRM2,ROCK2,RUNX3,S100A11,SFPQ,SMC4,SMARCC1,SNAI2,SOCS3,SRSF2,RBPJ,SUZ12,TPT1,TNFSF13B,TOP1,TWF1,VDR,WLS,YBX1,ENO1,FASN,IDH3A,PFKL,PFKFB3,SLC16A1,CALR,SMARCA4,NPM1,DUSP9,GFPT1,IL6R,FOXK2,LSS,MDK,TRIM37,PPP3CA,RCN1,BRD2,SOAT1,SQLE,SPHK1,SGPL1,SAFB2,G3BP1,PMVK,NUPR1,TRIB3,APP,ACAT2	Malignant cells	GSE108397	GSE108397	NA	6
Irregularity in Drug Uptake and Drug Efflux	0.14	0.35	2772	37	7	23467	SLC3A2,ABCB5,SLC2A1,ABCF2,SLC7A5,SLC7A11,SLC29A1	Malignant cells	GSE108397	GSE108397	NA	7
Aberration of the Drug's Therapeutic Target	0.63	0.79	2772	90	10	23467	AKT2,BRCA1,CDK4,MTOR,CDKN2A,EZH2,FGFR1,JAK1,NPM1,TOP2A	Malignant cells	GSE108397	GSE108397	NA	8
Drug Inactivation by Structure Modification	0.63	0.79	2772	27	3	23467	GSTP1,DCK,CMPK1	Malignant cells	GSE108397	GSE108397	NA	9
Epigenetic Alteration of DNA, RNA or Protein	1	1	2772	455	22	23467	BECN1,DNMT1,GSK3B,H2AFY,EIF4G2,LMNA,PPARG,SPRY2,TRIP6,TYMS,XIAP,PMAIP1,CDKN2A,EZH2,GAPDH,SMC4,TIMP1,TNFSF13B,MALAT1,PPP1R15A,MT-CO2,DLEU1	Malignant cells	GSE108397	GSE108397	NA	10
Unusual Activation of Pro-survival Pathway	7.8e-13	3.9e-12	1398	781	99	23467	AKAP1,ANXA2,AURKA,BCL11A,BCAT1,CTSL,CDK4,CDK6,CDKN1A,CIAPIN1,CTNNB1,DLK1,EPAS1,GSTP1,SLC2A1,HIF1A,HMGA1,ID1,MAGEA6,MAGEA12,NFE2L2,PARP1,PTEN,PTPN11,KRAS,RALBP1,RHOA,RPS6,SFRP1,SHC1,SOX2,SOX9,STMN1,TYMS,AKAP12,ANK2,BAG1,BID,HSPA5,BRD7,BTG1,CCNB1,CCND1,ALCAM,DKK1,DHFR,HSP90B1,EZH2,FANCA,FYN,GAPDH,GRB2,HDAC1,HMGN5,HNRNPU,HSPB1,IDH1,EIF4A1,ITGB1,KDM5B,LDHA,MAP3K1,MYCN,NFATC3,OAZ2,PDE4D,PSMG2,PTPN1,RAC1,RAP1B,HRAS,RAB22A,RRM1,HNRNPA1,RSU1,SDC2,SLAIN1,SMARCC1,SOD2,SRI,STK4,TMEM54,TOP1,YY1,UBE2C,USP14,YBX1,YEATS4,FASN,GNAS,CALR,RET,NPM1,CEBPD,MDK,PRKCA,TM7SF2,PMVK,QPRT	Malignant cells	GSE115251	GSE115251	NA	11
Aberration of the Drug's Therapeutic Target	0.087	0.22	1398	90	9	23467	CDK4,CDK6,DHFR,EZH2,IDH1,SF3B1,RET,NPM1,COMT	Malignant cells	GSE115251	GSE115251	NA	12
Drug Inactivation by Structure Modification	0.22	0.36	1398	27	3	23467	GSTP1,GSS,SOD2	Malignant cells	GSE115251	GSE115251	NA	13
Irregularity in Drug Uptake and Drug Efflux	0.9	1	1398	37	1	23467	SLC2A1	Malignant cells	GSE115251	GSE115251	NA	14
Epigenetic Alteration of DNA, RNA or Protein	1	1	1398	455	9	23467	H2AFY,EIF4G2,TYMS,EZH2,GAPDH,IDH1,MALAT1,RET,SMYD2	Malignant cells	GSE115251	GSE115251	NA	15
Unusual Activation of Pro-survival Pathway	3.3e-15	1.6e-14	1319	781	101	23467	AKAP1,ANXA2,ATG12,AURKA,CDK4,CDKN1B,TP53,CIAPIN1,DLK1,GSTP1,SLC2A1,HIF1A,HMGA1,HOXB3,ID1,IDH2,IFI27,ISG15,PKM,RPS6,SOX2,SOX4,STMN1,TPD52,TYMS,SLC25A5,TFAP2A,ARID1A,ATG4B,BNIP2,BRD4,BRD7,CCNB1,CDK1,CCNG1,ALCAM,CDC27,CDKN2A,CRBN,CREB1,CXCR4,DCK,DNMT3A,DHFR,EHF,ERCC1,EZR,FIS1,FTL,GAPDH,GAS6,NR3C1,HAX1,HDAC1,HMGB2,HMGN5,HNRNPU,HSPB1,EIF4A3,TCF4,KDM5B,KLF4,LDHA,LRRFIP1,MDM4,MYBL2,NQO1,NUCKS1,TP73,PABPC1,AGPAT2,PTPN1,HRAS,REV1,RRM2,RSF1,SDHB,SMC4,SOCS3,SRSF2,STAT3,SUZ12,TMEM54,TOP1,TUSC3,UBE2C,USP14,USP22,UCP2,WLS,YBX1,ENO1,GNAS,CALR,EIF4EBP1,BRD2,NKX2-1,G3BP1,PMVK,EBP,CERS6	Malignant cells	GSE138267	GSE138267	NA	16
Drug Inactivation by Structure Modification	0.19	0.4	1319	27	3	23467	GSTP1,DCK,CMPK1	Malignant cells	GSE138267	GSE138267	NA	17
Aberration of the Drug's Therapeutic Target	0.24	0.4	1319	90	7	23467	CDK4,TP53,IDH2,CDKN2A,CRBN,DHFR,TOP2A	Malignant cells	GSE138267	GSE138267	NA	18
Irregularity in Drug Uptake and Drug Efflux	0.35	0.43	1319	37	3	23467	SLC3A2,SLC2A1,TAP1	Malignant cells	GSE138267	GSE138267	NA	19
Epigenetic Alteration of DNA, RNA or Protein	0.99	0.99	1319	455	16	23467	TP53,H2AFY,IDH2,EIF4G2,LMNA,TYMS,PMAIP1,CDKN2A,CXCR4,DNMT3A,GAPDH,SMC4,TIMP1,MALAT1,GDI2,MT-CO2	Malignant cells	GSE138267	GSE138267	NA	20
Unusual Activation of Pro-survival Pathway	5e-21	2.5e-20	3441	781	214	23467	AKT2,ATG12,AURKA,BAX,BBC3,BIK,BIRC5,BRCA1,CDK4,CDK6,CDKN1A,CERS2,DCTD,DNMT1,DUSP6,EGFR,FUBP1,GLS,GSTP1,SLC2A1,HMGA1,HMGB1,ID1,EIF4G1,ISG15,JUN,PKM,MCL1,MAPK1,MAP1LC3B,MTA1,NFE2L2,NFKB1,PARP1,PEA15,PPARG,PTEN,RAB6A,KRAS,RALBP1,RHOA,RPS6,S100A4,SOCS2,SOX2,STMN1,TGFBR2,PBK,TPD52,TRIM16,TYMS,VEGFA,VOPP1,XIAP,YAP1,YWHAZ,NT5C2,AAMDC,SLC25A5,AGR2,AKAP12,AKT3,ANXA1,TFAP2A,BAD,BAG3,BID,HSPA5,BRD4,BRD7,BTG1,CAV2,CCNA2,CCNB1,CDK1,CCND1,CCNE1,ALCAM,CDC27,CDK2,HSPD1,CSF1,CTNND1,CUL4A,DCK,DDIT3,DKK1,DHFR,E2F1,E2F3,EHF,HSP90B1,EPHA2,ERRFI1,EZH2,EZR,FAT1,FGFR1,FN1,FIS1,FOXM1,FTL,FUS,GAS6,NR3C1,GRB2,GCLM,GCLC,GSR,SLC16A3,HDAC3,HIPK2,HMGB2,HSPB1,HK1,IDH1,EIF4E,EIF5A2,JAG1,KEAP1,KLF4,LAMP3,LASP1,LDHA,LRRFIP1,MTDH,NF2,MAPK3,MOB1A,MAP2K1,MYBL2,MYD88,MYO10,NDST1,NFYB,NKD2,NUCKS1,OAZ2,SPP1,PDE4D,PGK1,PLK1,POMP,PRKDC,RAC1,RAF1,RANGAP1,RAP1A,RAP1B,HRAS,NRAS,RAB27A,RECK,RNF2,RRM1,RRM2,HNRNPA1,RUNX2,SAV1,SDHB,SFPQ,SMAD3,SMC4,SNAI2,SOD2,SRI,SPIN1,SRSF2,STARD10,RBPJ,TFAM,TMED3,TMEM54,TNFAIP3,TOP1,UBE2C,USP22,AXL,PLAU,VEGFC,WNT5A,XRCC3,YBX1,ZKSCAN1,FASN,PFKL,SLC16A1,CALR,SMARCA4,NPM1,DHCR24,EIF4EBP1,GFPT1,HMGCS1,IDI1,MDK,PDK2,PPP3CA,RELB,BRD2,SQLE,TM7SF2,WNT7B,GGPS1,G3BP1,EBP,TNFAIP8,TRIB3,CERS6,CREBZF,APP,WTAP,ACAT2,BIRC2	Malignant cells	GSE139386	GSE139386	NA	21
Drug Inactivation by Structure Modification	0.035	0.088	3441	27	8	23467	GSTP1,NT5C2,CYP1B1,DCK,CES1,SOD2,CDA,NME1	Malignant cells	GSE139386	GSE139386	NA	22
Aberration of the Drug's Therapeutic Target	0.45	0.58	3441	90	14	23467	AKT2,BRCA1,CDK4,CDK6,EGFR,DHFR,EZH2,FGFR1,IDH1,MAP2K1,JAK1,NPM1,AKR1B1,TOP2A	Malignant cells	GSE139386	GSE139386	NA	23
Irregularity in Drug Uptake and Drug Efflux	0.46	0.58	3441	37	6	23467	SLC3A2,SLC2A1,ABCC1,ABCF2,SLC7A5,ABCC5	Malignant cells	GSE139386	GSE139386	NA	24
Epigenetic Alteration of DNA, RNA or Protein	1	1	3441	455	25	23467	BIK,DNMT1,EGFR,H2AFY,EIF4G2,LMNA,MTA1,PPARG,TRIP6,TYMS,XIAP,BMF,EZH2,IDH1,MAPK3,SMC4,TIMP1,MALAT1,GDI2,AKT3,PPP1R15A,SMYD2,MT-CO2,DLEU1,NABP1	Malignant cells	GSE139386	GSE139386	NA	25
Unusual Activation of Pro-survival Pathway	9.8e-06	4.9e-05	2352	781	116	23467	ADAM9,ANXA2,AREG,BCAT1,BIRC5,BRCA1,CCND2,CDCP1,CDK6,CDKN1A,DNMT1,FAM168A,GSK3B,HOXA13,IGF2BP1,JUN,MAP1LC3B,PARP1,SOCS2,SPRY2,TGFB1,TGFBR2,PBK,TYMS,VEGFA,AAMDC,ADAM22,SLC25A5,AGR2,ANXA1,BCL10,BTG1,BUB1,CBL,CCNA2,CCNB1,CDK1,CCND1,CCNG2,CD44,HSPD1,CLTC,CLU,CUL4B,CYLD,DUSP2,DHFR,E2F2,ENG,ERCC1,ETS1,EZH2,FANCD2,FGFR1,FUS,FZD1,GPER1,GRB2,GCLM,SLC16A3,HMGB2,HMGN5,HSPA8,EIF4A3,IL1B,CXCL8,ING4,ITGA5,ITGB1,KIF11,KLF4,LDHA,MXD4,NF2,MYBL2,MYO10,NOTCH3,PARP8,PDCD4,PLK1,PSMB5,PTPN12,RAD51,RAB22A,RAB27A,RICTOR,RRM1,RRM2,ROCK2,SDC2,SMC4,SNAI2,SRI,STARD10,TERT,TFAM,TMEM54,TOP2B,USP14,USP22,PLAU,ERCC4,YEATS4,PFKFB3,GNAS,HMGCS1,INSIG1,ITGB3,PRKCA,RCN1,SQLE,SPHK1,GGPS1,SAFB2,PDSS1,ACAT2	Malignant cells	GSE140440	GSE140440	NA	26
Irregularity in Drug Uptake and Drug Efflux	0.16	0.36	2352	37	6	23467	ABCB1,ABCC2,ABCA10,ABCF2,ABCE1,ABCG1	Malignant cells	GSE140440	GSE140440	NA	27
Drug Inactivation by Structure Modification	0.28	0.36	2352	27	4	23467	GSS,NME1,CMPK1,CYP51A1	Malignant cells	GSE140440	GSE140440	NA	28
Aberration of the Drug's Therapeutic Target	0.29	0.36	2352	90	11	23467	BRCA1,CDK6,DHFR,EZH2,FGFR1,IL1B,JAK1,COMT,DPP4,MAOA,TOP2A	Malignant cells	GSE140440	GSE140440	NA	29
Epigenetic Alteration of DNA, RNA or Protein	1	1	2352	455	20	23467	DNMT1,GSK3B,H2AFY,HOXA13,EIF4G2,SPRY2,TYMS,EZH2,CXCL8,PDCD4,SMC4,TIMP1,SNHG1,LINC00261,GDI2,CDK14,CDR1,MX1,LINC00707,RP11-166P13.3	Malignant cells	GSE140440	GSE140440	NA	30
Unusual Activation of Pro-survival Pathway	2.4e-06	1.2e-05	164	781	19	23467	GSTP1,HMGA1,PKM,S100A4,SOX4,ALDH1A3,ANXA1,CAV2,HSPD1,CAPNS1,FTL,LDHA,RSF1,S100A11,TPT1,YBX1,ENO1,GNAS,NUPR1	Malignant cells	GSE149214	GSE149214	NA	31
Irregularity in Drug Uptake and Drug Efflux	0.028	0.069	164	37	2	23467	SLC3A2,SLC7A11	Malignant cells	GSE149214	GSE149214	NA	32
Drug Inactivation by Structure Modification	0.17	0.29	164	27	1	23467	GSTP1	Malignant cells	GSE149214	GSE149214	NA	33
Aberration of the Drug's Therapeutic Target	0.47	0.59	164	90	1	23467	AKR1B1	Malignant cells	GSE149214	GSE149214	NA	34
Epigenetic Alteration of DNA, RNA or Protein	0.83	0.83	164	455	2	23467	LMNA,MALAT1	Malignant cells	GSE149214	GSE149214	NA	35
Unusual Activation of Pro-survival Pathway	0.0021	0.01	85	781	9	23467	BCL2,GSTP1,JUN,MAP1LC3B,BTG1,CD44,CXCR4,DUSP1,HSPA8	Malignant cells	GSE152469	GSE152469	NA	36
Epigenetic Alteration of DNA, RNA or Protein	0.083	0.16	85	455	4	23467	BCL2,PMAIP1,CXCR4,PPP1R15A	Malignant cells	GSE152469	GSE152469	NA	37
Drug Inactivation by Structure Modification	0.093	0.16	85	27	1	23467	GSTP1	Malignant cells	GSE152469	GSE152469	NA	38
Aberration of the Drug's Therapeutic Target	0.28	0.35	85	90	1	23467	BCL2	Malignant cells	GSE152469	GSE152469	NA	39
Irregularity in Drug Uptake and Drug Efflux	1	1	85	37	0	23467		Malignant cells	GSE152469	GSE152469	NA	40
Regulation by the Disease Microenvironment	0.28	0.28	41	186	1	23467	CXCR4	CD8+ T cells	GSE152469	GSE152469	NA	41
Regulation by the Disease Microenvironment	0.054	0.054	7	186	1	23467	CXCR4	NK cells	GSE152469	GSE152469	NA	42
Unusual Activation of Pro-survival Pathway	5.8e-14	2.9e-13	1239	781	94	23467	ANXA2,AREG,BCL11A,CCND2,CDK4,CDKN1A,CDKN1B,CERS2,CIAPIN1,CTNNB1,DNMT1,GAS7,GSTP1,SLC2A1,HIF1A,HMGA1,HMGB1,IDH2,JUN,PKM,MCL1,MAP1LC3B,MYC,PARP1,RHOA,S100A4,STMN1,TP53INP1,YWHAZ,SLC25A5,GRK2,BID,BNIP2,BTG1,CD44,HSPD1,CHEK1,CLTC,DCK,DNMT3A,DUSP1,DHFR,ENG,EIF3A,HSP90B1,EZR,GAPDH,NR3C1,HAX1,HMGB2,HSPA8,HSPB1,IKZF1,KDM5B,KEAP1,LDHA,LRRFIP1,MDM4,MSH2,MSH6,MYD88,NUCKS1,PABPC1,PGK1,PIK3CD,PRKDC,PSMB5,RAP1B,RRM1,HNRNPA1,SDHB,SFPQ,SMC4,SOD2,SRSF2,TPT1,TFAM,TOP1,TOP2B,TRIM27,UCP2,YEATS4,ZKSCAN1,ENO1,GNAS,CALR,SMARCA4,NPM1,EIF4EBP1,REL,BRD2,OGT,G3BP1,HSH2D	Malignant cells	GSE153697	GSE153697	NA	43
Aberration of the Drug's Therapeutic Target	0.1	0.21	1239	90	8	23467	CDK4,IDH2,DHFR,MSH6,CD19,SF3B1,NPM1,AKR1B1	Malignant cells	GSE153697	GSE153697	NA	44
Irregularity in Drug Uptake and Drug Efflux	0.13	0.21	1239	37	4	23467	SLC2A1,ABCE1,TAP1,SLC29A1	Malignant cells	GSE153697	GSE153697	NA	45
Drug Inactivation by Structure Modification	0.17	0.21	1239	27	3	23467	GSTP1,DCK,SOD2	Malignant cells	GSE153697	GSE153697	NA	46
Epigenetic Alteration of DNA, RNA or Protein	1	1	1239	455	13	23467	DNMT1,H2AFY,IDH2,EIF4G2,LMNA,PMAIP1,ARID4B,DNMT3A,GAPDH,SMC4,MALAT1,PPP1R15A,MT-CO2	Malignant cells	GSE153697	GSE153697	NA	47
Regulation by the Disease Microenvironment	0.024	0.024	30	186	2	23467	ZEB2,CXCR4	Mono_Macro	GSE153697	GSE153697	NA	48
Regulation by the Disease Microenvironment	1	1	62	186	0	23467	NA	Physiology B cells	GSE153697	GSE153697	NA	49
Unusual Activation of Pro-survival Pathway	0.005	0.025	97	781	9	23467	HSPA5,CCND1,HSP90B1,FTL,GAPDH,LDHA,TPT1,YBX1,ENO1	Malignant cells	GSE161195_pre	GSE161195	pre	50
Epigenetic Alteration of DNA, RNA or Protein	0.56	1	97	455	2	23467	GAPDH,MT-CO2	Malignant cells	GSE161195_pre	GSE161195	pre	51
Aberration of the Drug's Therapeutic Target	1	1	97	90	0	23467		Malignant cells	GSE161195_pre	GSE161195	pre	52
Drug Inactivation by Structure Modification	1	1	97	27	0	23467		Malignant cells	GSE161195_pre	GSE161195	pre	53
Irregularity in Drug Uptake and Drug Efflux	1	1	97	37	0	23467		Malignant cells	GSE161195_pre	GSE161195	pre	54
Unusual Activation of Pro-survival Pathway	2.2e-07	1.1e-06	511	781	41	23467	ANXA2,CCND2,CDKN1A,CFLAR,FBXW7,GSTP1,IDH2,IFI27,ISG15,MAP1LC3B,MYC,RHOA,RPS6,S100A4,HSPA5,CCND1,HSPD1,CXCR4,DKK1,HSP90B1,GAPDH,HAX1,HMGB2,HSPA8,NFKBIA,LDHA,NSD2,NUCKS1,PDCD4,POMP,SRSF2,UCP2,ENO1,CALR,FGFR3,INSIG1,MDK,RCN1,PMVK,QPRT,APP	Malignant cells	GSE161801_IMiD_post	GSE161801_IMiD	post	55
Drug Inactivation by Structure Modification	0.45	0.66	511	27	1	23467	GSTP1	Malignant cells	GSE161801_IMiD_post	GSE161801_IMiD	post	56
Irregularity in Drug Uptake and Drug Efflux	0.56	0.66	511	37	1	23467	SLC3A2	Malignant cells	GSE161801_IMiD_post	GSE161801_IMiD	post	57
Aberration of the Drug's Therapeutic Target	0.59	0.66	511	90	2	23467	IDH2,FGFR3	Malignant cells	GSE161801_IMiD_post	GSE161801_IMiD	post	58
Epigenetic Alteration of DNA, RNA or Protein	0.66	0.66	511	455	9	23467	FBXW7,IDH2,PMAIP1,CXCR4,GAPDH,PDCD4,CYTOR,MALAT1,PPP1R15A	Malignant cells	GSE161801_IMiD_post	GSE161801_IMiD	post	59
Regulation by the Disease Microenvironment	1	1	31	186	0	23467	NA	B cells	GSE161801_IMiD_post	GSE161801_IMiD	post	60
Regulation by the Disease Microenvironment	1	1	81	186	0	23467	NA	CD4+ T cells	GSE161801_IMiD_post	GSE161801_IMiD	post	61
Regulation by the Disease Microenvironment	0.49	0.49	85	186	1	23467	CXCR4	CD8+ T cells	GSE161801_IMiD_post	GSE161801_IMiD	post	62
Regulation by the Disease Microenvironment	1	1	8	186	0	23467	NA	cDCs	GSE161801_IMiD_post	GSE161801_IMiD	post	63
Regulation by the Disease Microenvironment	1	1	29	186	0	23467	NA	Erythrocytes	GSE161801_IMiD_post	GSE161801_IMiD	post	64
Regulation by the Disease Microenvironment	0.48	0.48	82	186	1	23467	IL1B	Mono_Macro	GSE161801_IMiD_post	GSE161801_IMiD	post	65
Regulation by the Disease Microenvironment	0.51	0.51	89	186	1	23467	CXCR4	NK cells	GSE161801_IMiD_post	GSE161801_IMiD	post	66
Regulation by the Disease Microenvironment	1	1	17	186	0	23467	NA	Progenitors	GSE161801_IMiD_post	GSE161801_IMiD	post	67
Unusual Activation of Pro-survival Pathway	1.7e-12	8.5e-12	486	781	50	23467	ANXA2,AREG,BCL2L11,FBXW7,GSTP1,HMGB1,IFI27,ISG15,JUN,MCL1,RHOA,S100A4,STMN1,TP53INP1,VOPP1,YWHAZ,SLC25A5,HSPA5,BMI1,CCND1,CCNG1,HSPD1,CXCR4,DUSP1,DUSP2,EGR1,HSP90B1,FTL,GAPDH,HMGB2,HSPA8,NFKBIA,MTDH,MDM4,NSD2,NUCKS1,PABPC1,RAC1,HNRNPA1,S100A11,SIAH2,TPT1,UCP2,YBX1,CALR,FGFR3,NPM1,MDK,RCN1,PMVK	Malignant cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	68
Epigenetic Alteration of DNA, RNA or Protein	0.15	0.38	486	455	13	23467	BCL2L11,FBXW7,LMNA,PMAIP1,BMI1,CXCR4,GAPDH,TIMP1,CYTOR,MALAT1,PPP1R15A,MT-CO2,MX1	Malignant cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	69
Drug Inactivation by Structure Modification	0.43	0.56	486	27	1	23467	GSTP1	Malignant cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	70
Irregularity in Drug Uptake and Drug Efflux	0.54	0.56	486	37	1	23467	ABCB9	Malignant cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	71
Aberration of the Drug's Therapeutic Target	0.56	0.56	486	90	2	23467	FGFR3,NPM1	Malignant cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	72
Regulation by the Disease Microenvironment	0.069	0.069	119	186	3	23467	MYC,CXCR4,VIM	B cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	73
Regulation by the Disease Microenvironment	0.064	0.064	52	186	2	23467	SOCS3,VIM	CD4+ T cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	74
Regulation by the Disease Microenvironment	0.2	0.2	103	186	2	23467	VIM,MALAT1	CD8+ T cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	75
Regulation by the Disease Microenvironment	1	1	59	186	0	23467	NA	cDCs	GSE161801_IMiD_pre	GSE161801_IMiD	pre	76
Regulation by the Disease Microenvironment	1	1	40	186	0	23467	NA	Erythrocytes	GSE161801_IMiD_pre	GSE161801_IMiD	pre	77
Regulation by the Disease Microenvironment	0.14	0.14	82	186	2	23467	IL1B,VIM	Mono_Macro	GSE161801_IMiD_pre	GSE161801_IMiD	pre	78
Regulation by the Disease Microenvironment	0.25	0.25	122	186	2	23467	CXCR4,VIM	NK cells	GSE161801_IMiD_pre	GSE161801_IMiD	pre	79
Regulation by the Disease Microenvironment	1	1	1	186	0	23467	NA	pDCs	GSE161801_IMiD_pre	GSE161801_IMiD	pre	80
Regulation by the Disease Microenvironment	1	1	13	186	0	23467	NA	Progenitors	GSE161801_IMiD_pre	GSE161801_IMiD	pre	81
Unusual Activation of Pro-survival Pathway	2e-06	1e-05	537	781	40	23467	ADAM10,CDKN1A,GSTP1,IDH2,IFI27,ISG15,JUN,MYC,RHOA,VOPP1,YWHAZ,SLC25A5,HSPA5,BTG1,CCND1,HSPD1,CLTC,CXCR4,DUSP1,HSP90B1,EZR,FOXO3,GAS6,HAX1,HMGB2,HSPA8,NFKBIA,MTDH,PABPC1,HNRNPA1,S100A11,SRI,TPT1,ENO1,CALR,NPM1,EIF4EBP1,RCN1,HSH2D,APP	Malignant cells	GSE161801_PI_post	GSE161801_PI	post	82
Drug Inactivation by Structure Modification	0.46	0.61	537	27	1	23467	GSTP1	Malignant cells	GSE161801_PI_post	GSE161801_PI	post	83
Epigenetic Alteration of DNA, RNA or Protein	0.47	0.61	537	455	11	23467	IDH2,PMAIP1,CXCR4,FOXO3,TIMP1,CYTOR,MALAT1,PPP1R15A,MT-CO2,MX1,GABPB1-AS1	Malignant cells	GSE161801_PI_post	GSE161801_PI	post	84
Irregularity in Drug Uptake and Drug Efflux	0.58	0.61	537	37	1	23467	ABCB9	Malignant cells	GSE161801_PI_post	GSE161801_PI	post	85
Aberration of the Drug's Therapeutic Target	0.61	0.61	537	90	2	23467	IDH2,NPM1	Malignant cells	GSE161801_PI_post	GSE161801_PI	post	86
Regulation by the Disease Microenvironment	0.084	0.084	61	186	2	23467	CXCR4,MALAT1	B cells	GSE161801_PI_post	GSE161801_PI	post	87
Regulation by the Disease Microenvironment	1	1	32	186	0	23467	NA	CD4+ T cells	GSE161801_PI_post	GSE161801_PI	post	88
Regulation by the Disease Microenvironment	1	1	121	186	0	23467	NA	CD8+ T cells	GSE161801_PI_post	GSE161801_PI	post	89
Regulation by the Disease Microenvironment	0.066	0.066	53	186	2	23467	CXCR4,VIM	cDCs	GSE161801_PI_post	GSE161801_PI	post	90
Regulation by the Disease Microenvironment	0.071	0.071	196	186	4	23467	CXCR4,RHOB,VIM,MALAT1	Mono_Macro	GSE161801_PI_post	GSE161801_PI	post	91
Regulation by the Disease Microenvironment	0.74	0.74	167	186	1	23467	MALAT1	NK cells	GSE161801_PI_post	GSE161801_PI	post	92
Unusual Activation of Pro-survival Pathway	1e-04	5e-04	593	781	38	23467	ANXA2,CDKN1A,CFLAR,IDH2,IFI27,JUN,MCL1,RPS6,S100A4,VOPP1,YWHAZ,SLC25A5,BTG1,CCND1,CCNG1,CD44,CXCR4,DUSP1,EGR1,HSP90B1,EZR,FTL,GAPDH,GAS6,HSPA8,EIF4E,NFKBIA,LDHA,MTDH,PABPC1,PDCD4,RAP1B,HNRNPA1,TPT1,TNFSF10,YBX1,GNAS,NPM1	Malignant cells	GSE161801_PI_pre	GSE161801_PI	pre	93
Aberration of the Drug's Therapeutic Target	0.4	1	593	90	3	23467	IDH2,NPM1,LAG3	Malignant cells	GSE161801_PI_pre	GSE161801_PI	pre	94
Irregularity in Drug Uptake and Drug Efflux	0.61	1	593	37	1	23467	SLC7A5	Malignant cells	GSE161801_PI_pre	GSE161801_PI	pre	95
Epigenetic Alteration of DNA, RNA or Protein	0.89	1	593	455	8	23467	IDH2,LMNA,PMAIP1,CXCR4,GAPDH,PDCD4,CYTOR,MT-CO2	Malignant cells	GSE161801_PI_pre	GSE161801_PI	pre	96
Drug Inactivation by Structure Modification	1	1	593	27	0	23467		Malignant cells	GSE161801_PI_pre	GSE161801_PI	pre	97
Regulation by the Disease Microenvironment	1	1	101	186	0	23467	NA	B cells	GSE161801_PI_pre	GSE161801_PI	pre	98
Regulation by the Disease Microenvironment	0.26	0.26	37	186	1	23467	MALAT1	CD4+ T cells	GSE161801_PI_pre	GSE161801_PI	pre	99
Regulation by the Disease Microenvironment	0.0098	0.0098	105	186	4	23467	TGFB1,CXCR4,VIM,MALAT1	CD8+ T cells	GSE161801_PI_pre	GSE161801_PI	pre	100
Regulation by the Disease Microenvironment	0.18	0.18	25	186	1	23467	MALAT1	cDCs	GSE161801_PI_pre	GSE161801_PI	pre	101
Regulation by the Disease Microenvironment	0.008	0.008	155	186	5	23467	ZEB2,IL1B,RHOB,VIM,MALAT1	Mono_Macro	GSE161801_PI_pre	GSE161801_PI	pre	102
Regulation by the Disease Microenvironment	0.42	0.42	180	186	2	23467	ZEB2,MALAT1	NK cells	GSE161801_PI_pre	GSE161801_PI	pre	103
Unusual Activation of Pro-survival Pathway	9.2e-12	4.6e-11	1761	781	113	23467	ANXA2,AURKA,BAX,CDK4,CDK6,CERS2,CRYAB,DCTD,DNMT1,EGFR,FADD,GSTP1,HMGA1,HSPA1A,ID1,IDH2,IFI27,JUN,PKM,MTA1,NFE2L2,PARP1,PEA15,RPS6,S100A4,ST3GAL4,SOX4,SOX9,STMN1,TPD52,YWHAZ,SLC25A5,ALDH1A3,ANXA1,ATG3,BAD,BID,BRD4,BTG1,CCND1,CCNE1,CCNG1,CD44,CDKN2A,CLTC,CAPNS1,DUSP1,DUSP2,DHFR,E2F1,EHF,EIF3A,HSP90B1,EZH2,GAPDH,G6PD,HAX1,HDAC3,HMGB2,HSPB1,EIF4A1,EIF4A3,ITGB1,JAG1,KEAP1,LDHA,MGMT,MOB1A,MAP2K1,MSH6,MYBL2,NOTCH2,NOTCH3,NTRK2,NUCKS1,OAZ2,PABPC1,PGK1,AGPAT2,POMP,PRKDC,PSMB5,RAC1,RAF1,RAB22A,RRM2,RND3,HNRNPA1,RSU1,SDC2,SDHB,SFPQ,SIAH2,SMC4,SMUG1,TPT1,UCP2,YBX1,YEATS4,ZNF217,ENO1,FASN,GNAS,CALR,GNAQ,CEBPD,EIF4EBP1,TM7SF2,PMVK,EBP,NUPR1,SIRT6,ACAT2	Malignant cells	GSE163836	GSE163836	NA	104
Aberration of the Drug's Therapeutic Target	0.017	0.042	1761	90	13	23467	CDK4,CDK6,EGFR,IDH2,CDKN2A,DHFR,EZH2,MAP2K1,MSH6,SF3B1,COMT,AKR1B1,TOP2A	Malignant cells	GSE163836	GSE163836	NA	105
Drug Inactivation by Structure Modification	0.14	0.23	1761	27	4	23467	GSTP1,CYP1B1,NME1,CMPK1	Malignant cells	GSE163836	GSE163836	NA	106
Irregularity in Drug Uptake and Drug Efflux	0.78	0.97	1761	37	2	23467	ABCB1,SLC34A2	Malignant cells	GSE163836	GSE163836	NA	107
Epigenetic Alteration of DNA, RNA or Protein	1	1	1761	455	13	23467	DNMT1,EGFR,H2AFY,IDH2,MTA1,CDKN2A,EZH2,GAPDH,SMC4,TIMP1,MALAT1,SMYD2,MT-CO2	Malignant cells	GSE163836	GSE163836	NA	108
Regulation by the Disease Microenvironment	0.058	0.058	49	186	2	23467	ZEB2,VIM	CD8+ T cells	GSE164237_post	GSE164237	post	109
Regulation by the Disease Microenvironment	0.032	0.032	222	186	5	23467	ZEB2,CX3CR1,CXCR4,VIM,MALAT1	CD8+ T cells	GSE164237_pre	GSE164237	pre	110
Unusual Activation of Pro-survival Pathway	0.059	0.29	12	781	2	23467	EGR1,CXCL8	Malignant cells	GSE164551	GSE164551	NA	111
Epigenetic Alteration of DNA, RNA or Protein	0.21	0.52	12	455	1	23467	CXCL8	Malignant cells	GSE164551	GSE164551	NA	112
Aberration of the Drug's Therapeutic Target	1	1	12	90	0	23467		Malignant cells	GSE164551	GSE164551	NA	113
Drug Inactivation by Structure Modification	1	1	12	27	0	23467		Malignant cells	GSE164551	GSE164551	NA	114
Irregularity in Drug Uptake and Drug Efflux	1	1	12	37	0	23467		Malignant cells	GSE164551	GSE164551	NA	115
Regulation by the Disease Microenvironment	1	1	3	186	0	23467	NA	B cells	GSE164551	GSE164551	NA	116
Regulation by the Disease Microenvironment	0.0066	0.0066	148	186	5	23467	BRAF,TGFB1,SOCS3,VIM,ZEB1	CD4+ T cells	GSE164551	GSE164551	NA	117
Regulation by the Disease Microenvironment	0.18	0.18	276	186	4	23467	NFKB1,TGFB1,CXCR4,VIM	CD8+ T cells	GSE164551	GSE164551	NA	118
Regulation by the Disease Microenvironment	0.51	0.51	467	186	4	23467	BCL2L1,MTDH,HNRNPA2B1,MALAT1	Erythrocytes	GSE164551	GSE164551	NA	119
Regulation by the Disease Microenvironment	0.0092	0.0092	524	186	10	23467	BRAF,CTNNB1,TGFB1,VEGFA,ZEB2,IL1B,HNRNPA2B1,SOCS3,VIM,MALAT1	Mono_Macro	GSE164551	GSE164551	NA	120
Regulation by the Disease Microenvironment	0.48	0.48	81	186	1	23467	VIM	NK cells	GSE164551	GSE164551	NA	121
Unusual Activation of Pro-survival Pathway	9.2e-29	4.6e-28	2874	781	208	23467	PPP2R5A,ADAM10,ADAM9,AKT2,ANXA2,AREG,CDH1,CDK6,CDKN1A,CUL5,DUSP6,GLS,HIF1A,HMGB1,HMOX1,HSPA1A,EIF4G1,IFI27,JUN,PKM,MAGEA6,MAGEA12,MCL1,MEF2D,MET,MAPK1,MUC1,MYC,NFKB1,PARP1,RAB6A,KRAS,RPS6,SELENOW,SMAD4,SOX4,SOX9,SRC,STMN1,TGFBR2,TPD52,TYMS,VOPP1,XIAP,YAP1,YWHAZ,SLC25A5,AGR2,AKAP12,AKT3,ANXA1,NET1,BAK1,BCL10,BID,BRD4,BTG1,CAV2,CCL2,ALCAM,CDC27,CDKN2A,CLU,CTNND1,CXCR4,DDR1,DICER1,DKK1,DUSP1,E2F6,EGR1,EGR2,EHF,HSP90B1,EP300,EPHA2,ERCC1,EREG,ETS1,EZH2,EZR,FAT1,FGF2,FN1,FIS1,FOXA1,FTL,FUS,GAPDH,GATA6,GRB2,GCLM,GSR,HBEGF,HIPK3,HMGB2,HSPA8,HSPB1,IDH1,NFKBIA,CXCL8,JAG1,AK4,KAT6A,RPS6KA3,RPS6KB1,LAMP2,LASP1,LATS2,LDHA,MAP3K1,MAP3K5,MAP3K8,MAGEA3,MDM2,MED1,MITF,MAPK3,MOB1A,MAP2K2,IGF2R,MSH2,NF1,NQO1,NUCKS1,OAZ2,SPP1,PDCD10,PDE4D,PTGS2,PGK1,PRKDC,PSMB5,PTPN12,RAC1,RAP1B,RASSF1,RAB22A,RICTOR,RRM1,HNRNPA1,RSF1,RSU1,S100A8,S100A11,SAV1,SDC2,SFPQ,SIAH2,SIRT1,SMAD3,SMC4,SOCS6,SRI,SP1,SPIN1,SRF,STAT5B,TPT1,TFAM,TGFBR1,TNFAIP3,TNFSF10,TOM1,TOP1,TWF1,USP14,WEE1,YBX1,YES1,ZEB1,ZNF217,ENO1,FASN,MAGEA4,RASSF8,PFKFB3,GNAS,CALR,GNAQ,VHL,ARAF,NPM1,CEBPD,DHCR24,DUSP9,EIF4EBP1,EPHB4,GFPT1,HMGCR,LPL,MDK,PPP3CA,RCN1,REL,BRD2,SOAT1,SPHK1,GGPS1,PMVK,EBP,QPRT,UBR5,GSKIP,ALDH1A1,BIRC2,CD36,CDK7	Malignant cells	GSE175716	GSE175716	NA	122
Aberration of the Drug's Therapeutic Target	0.21	0.52	2874	90	14	23467	AKT2,CDK6,MET,CREBBP,CDKN2A,EZH2,IDH1,MAP2K2,PTGS2,JAK1,SF3B1,NPM1,AKR1B1,TOP2A	Malignant cells	GSE175716	GSE175716	NA	123
Drug Inactivation by Structure Modification	0.43	0.6	2874	27	4	23467	CES1,CDA,NME1,PON1	Malignant cells	GSE175716	GSE175716	NA	124
Irregularity in Drug Uptake and Drug Efflux	0.48	0.6	2874	37	5	23467	SLC3A2,ABCB1,ABCC2,SLC4A4,SLC7A11	Malignant cells	GSE175716	GSE175716	NA	125
Epigenetic Alteration of DNA, RNA or Protein	1	1	2874	455	27	23467	H2AFY,MET,TRIP6,TYMS,XIAP,CREBBP,CCL2,CDKN2A,CXCR4,EZH2,GAPDH,IDH1,CXCL8,MAP3K8,MAPK3,RASSF1,SIRT1,SMC4,TIMP1,SNHG14,GDI2,AKT3,PPP1R15A,SMYD2,MT-CO2,NABP1,HULC	Malignant cells	GSE175716	GSE175716	NA	126
Unusual Activation of Pro-survival Pathway	1.1e-17	5.7e-17	2539	781	165	23467	PPP2R5A,ANXA2,BAX,CDCP1,CDK4,CDK6,CDKN1A,CERS2,CFLAR,TP53,CUL5,DNMT1,FUBP1,HIF1A,HMGB1,HMOX1,HSPA1A,HOXB3,ISG15,PKM,MAPK1,MAP1LC3B,MTOR,NFE2L2,PARP1,PTPN11,RALBP1,RHOA,RPS6,S100A4,SFRP1,SHC1,SOX4,STMN1,TYMS,VEGFA,YWHAZ,NT5C2,ADAM17,SLC25A5,AGR2,AIFM1,AKAP12,AKT1,ANXA1,TFAP2A,ARID1A,BAD,HSPA5,BIRC6,BRD4,BRD7,BTG1,CAV2,CCNB1,CDK1,CCND1,CD44,CDK2,HSPD1,CLTC,COL1A1,CTNND1,DDIT3,DHFR,EIF3A,HSP90B1,EP300,ERRFI1,EZH2,EZR,FAT1,FGFR1,FIS1,FOXM1,FOXO3,FTL,FUS,GAPDH,GRB2,HDAC1,HMGB2,HNRNPU,HSPA8,HSPB1,HOXC9,IDH1,EIF4A1,EIF4A3,NFKBIA,ITGB1,AK4,KIF11,LAMP2,LDHA,LRRFIP1,MXD4,MDM2,MDM4,MGMT,MAPK3,MAP2K2,MSH6,MYBL2,MYO10,NOTCH2,NQO1,NUCKS1,PABPC1,PDCD10,PGK1,PIAS3,AGPAT2,PLK1,PRKDC,PSMG2,PURA,RANGAP1,HRAS,REV3L,RND3,HNRNPA1,ROCK2,RPP21,RSF1,S100A11,SDHB,SMC4,SMARCC1,SOD2,SRSF2,TPT1,TMEM54,TOP1,TRIM27,UBE2C,USP22,ULK1,WEE1,WLS,YES1,ZNF217,ENO1,FASN,PFKL,RASSF8,GNAS,BRCA2,PMS2,NPM1,EIF4EBP1,MDK,RCN1,BRD2,SQLE,TM7SF2,SAFB2,EBP,ACAP2,UBR5,TRIB3,APP,WTAP,ACAT2,CDK7	Malignant cells	GSE186960	GSE186960	NA	127
Aberration of the Drug's Therapeutic Target	0.016	0.039	2539	90	17	23467	CDK4,CDK6,TP53,MTOR,AKT1,DHFR,EZH2,FGFR1,IDH1,MAP2K2,MSH6,JAK1,SF3B1,NPM1,COMT,AKR1B1,TOP2A	Malignant cells	GSE186960	GSE186960	NA	128
Drug Inactivation by Structure Modification	0.33	0.46	2539	27	4	23467	NT5C2,SOD2,BCHE,NME1	Malignant cells	GSE186960	GSE186960	NA	129
Irregularity in Drug Uptake and Drug Efflux	0.37	0.46	2539	37	5	23467	SLC3A2,ABCC1,SLC7A5,SLC7A11,SLC29A1	Malignant cells	GSE186960	GSE186960	NA	130
Epigenetic Alteration of DNA, RNA or Protein	1	1	2539	455	20	23467	TP53,DNMT1,H2AFY,EIF4G2,LMNA,TYMS,PMAIP1,EZH2,FOXO3,GAPDH,IDH1,MAPK3,SMC4,TIMP1,SNHG14,MALAT1,GDI2,PPP1R15A,MT-CO2,GABPB1-AS1	Malignant cells	GSE186960	GSE186960	NA	131
Regulation by the Disease Microenvironment	0.049	0.049	103	186	3	23467	TGFB1,CXCR4,MALAT1	CD4+ T cells	GSE197268_Axi-cel_post	GSE197268_Axi-cel	post	132
Regulation by the Disease Microenvironment	0.071	0.071	196	186	4	23467	PARP1,GATA3,HNRNPA2B1,MALAT1	CD8+ T cells	GSE197268_Axi-cel_post	GSE197268_Axi-cel	post	133
Regulation by the Disease Microenvironment	0.52	0.52	91	186	1	23467	TGFB1	cDCs	GSE197268_Axi-cel_post	GSE197268_Axi-cel	post	134
Regulation by the Disease Microenvironment	0.24	0.24	117	186	2	23467	HNRNPA2B1,MALAT1	Mono_Macro	GSE197268_Axi-cel_post	GSE197268_Axi-cel	post	135
Regulation by the Disease Microenvironment	0.15	0.15	20	186	1	23467	MALAT1	NK cells	GSE197268_Axi-cel_post	GSE197268_Axi-cel	post	136
Regulation by the Disease Microenvironment	1	1	2	186	0	23467	NA	pDCs	GSE197268_Axi-cel_post	GSE197268_Axi-cel	post	137
Regulation by the Disease Microenvironment	0.22	0.22	32	186	1	23467	MYC	Progenitors	GSE197268_Axi-cel_post	GSE197268_Axi-cel	post	138
Regulation by the Disease Microenvironment	0.05	0.05	45	186	2	23467	BCL2,CXCR4	CD4+ T cells	GSE197268_Axi-cel_pre	GSE197268_Axi-cel	pre	139
Regulation by the Disease Microenvironment	1	1	42	186	0	23467	NA	CD8+ T cells	GSE197268_Axi-cel_pre	GSE197268_Axi-cel	pre	140
Regulation by the Disease Microenvironment	1	1	22	186	0	23467	NA	cDCs	GSE197268_Axi-cel_pre	GSE197268_Axi-cel	pre	141
Regulation by the Disease Microenvironment	1	1	57	186	0	23467	NA	Mono_Macro	GSE197268_Axi-cel_pre	GSE197268_Axi-cel	pre	142
Regulation by the Disease Microenvironment	0.52	0.52	93	186	1	23467	BCL2L1	NK cells	GSE197268_Axi-cel_pre	GSE197268_Axi-cel	pre	143
Regulation by the Disease Microenvironment	1	1	7	186	0	23467	NA	pDCs	GSE197268_Axi-cel_pre	GSE197268_Axi-cel	pre	144
Regulation by the Disease Microenvironment	0.06	0.06	50	186	2	23467	TGFB1,CXCR4	CD4+ T cells	GSE197268_Tisa-cel_post	GSE197268_Tisa-cel	post	145
Regulation by the Disease Microenvironment	0.031	0.031	35	186	2	23467	TGFB1,VIM	CD8+ T cells	GSE197268_Tisa-cel_post	GSE197268_Tisa-cel	post	146
Regulation by the Disease Microenvironment	0.37	0.37	58	186	1	23467	IL1B	Mono_Macro	GSE197268_Tisa-cel_post	GSE197268_Tisa-cel	post	147
Regulation by the Disease Microenvironment	0.6	0.6	114	186	1	23467	CX3CR1	NK cells	GSE197268_Tisa-cel_post	GSE197268_Tisa-cel	post	148
Regulation by the Disease Microenvironment	0.02	0.02	130	186	4	23467	BCL2,MYC,TGFB1,SOCS3	CD4+ T cells	GSE197268_Tisa-cel_pre	GSE197268_Tisa-cel	pre	149
Regulation by the Disease Microenvironment	0.32	0.32	146	186	2	23467	CXCR4,VIM	CD8+ T cells	GSE197268_Tisa-cel_pre	GSE197268_Tisa-cel	pre	150
Regulation by the Disease Microenvironment	0.046	0.046	326	186	6	23467	PAK1,CX3CR1,CXCR4,SOCS3,VIM,TIMP2	Mono_Macro	GSE197268_Tisa-cel_pre	GSE197268_Tisa-cel	pre	151
Regulation by the Disease Microenvironment	0.089	0.089	133	186	3	23467	TGFB1,CX3CR1,CXCR4	NK cells	GSE197268_Tisa-cel_pre	GSE197268_Tisa-cel	pre	152
Unusual Activation of Pro-survival Pathway	1.2e-23	6.1e-23	1932	781	151	23467	BCL2L11,BAX,BCL11A,BCAT1,BRAF,CTSL,CCND2,CDK4,CDK6,TP53,CTNNB1,DNMT1,GAS7,GSTP1,HIF1A,HMGA1,HMGB1,HMOX1,HSPA1A,IDH2,ISG15,JUN,PKM,MCL1,MEF2D,MAP1LC3B,MYC,NFKB1,PARP1,PIK3CG,RALBP1,RPS6,S100A4,ST3GAL4,SOX4,STMN1,TET2,TYMS,VEGFA,VOPP1,ZEB2,YWHAZ,ADAM17,ATG3,ATG4B,ATM,BID,HSPA5,BNIP2,BTG1,CASP1,CCNG1,CD44,HSPD1,CLU,CAPNS1,CXCR4,CYLD,DCP2,DUSP1,EP300,EZR,FIS1,FLT3,FOXO3,FTL,FUS,GAPDH,G6PD,NR3C1,HAX1,HBEGF,HDAC1,HMGB2,HSPA8,HSPB1,HOXA5,IDH1,NFKBIA,IL18,CXCL8,ING4,ITGB1,KAT6A,KLF4,LDHA,LRRFIP1,MAP3K8,MDM2,MDM4,MGMT,MOB1A,MAP2K2,NUCKS1,PIK3R1,PABPC1,PGK1,AGPAT2,PRKDC,PSMB5,PTPN1,RAB14,RAC1,RASSF1,RAB27A,RICTOR,RRM1,S100A8,S100A11,SFPQ,SMAD3,SMC4,SOCS3,SOD2,SRI,RBPJ,TPT1,TMED3,TNFSF13B,TNFAIP3,TOM1,TOP1,TOP2B,TRIM27,UCP2,ULK1,ZBTB7A,ZKSCAN1,ENO1,PFKL,PFKFB3,GNAS,CD33,CALR,SMARCA4,NPM1,CEBPD,EIF4EBP1,INSIG1,RCN1,REL,RELB,SPTLC2,G3BP1,PMVK,OGA,HSH2D,CREBZF,APP,WTAP,BIRC2	Malignant cells	GSE199333_post	GSE199333	post	153
Aberration of the Drug's Therapeutic Target	0.015	0.038	1932	90	14	23467	BRAF,CDK4,CDK6,TP53,IDH2,BTK,CREBBP,FLT3,IDH1,MAP2K2,SF3B1,NPM1,COMT,AKR1B1	Malignant cells	GSE199333_post	GSE199333	post	154
Drug Inactivation by Structure Modification	0.39	0.64	1932	27	3	23467	GSTP1,SOD2,NME1	Malignant cells	GSE199333_post	GSE199333	post	155
Irregularity in Drug Uptake and Drug Efflux	0.6	0.75	1932	37	3	23467	ABCA1,ABCE1,SLC7A5	Malignant cells	GSE199333_post	GSE199333	post	156
Epigenetic Alteration of DNA, RNA or Protein	0.97	0.97	1932	455	27	23467	BCL2L11,BRAF,TP53,DNMT1,IDH2,EIF4G2,LMNA,TYMS,PMAIP1,ARID4B,CREBBP,CXCR4,FOXO3,GAPDH,IDH1,CXCL8,MAP3K8,RASSF1,SMC4,TIMP1,TNFSF13B,CYTOR,MALAT1,GDI2,PPP1R15A,NABP1,GABPB1-AS1	Malignant cells	GSE199333_post	GSE199333	post	157
Regulation by the Disease Microenvironment	0.58	0.58	109	186	1	23467	PARP1	B cells	GSE199333_post	GSE199333	post	158
Regulation by the Disease Microenvironment	0.0046	0.0046	713	186	13	23467	BCL2,BRAF,NFKB1,PARP1,CXCR4,PIK3CA,HNRNPA2B1,STAT3,VIM,ZEB1,LDHB,MALAT1,TSPYL2	CD4+ T cells	GSE199333_post	GSE199333	post	159
Regulation by the Disease Microenvironment	0.0039	0.0039	617	186	12	23467	BCL2,BRAF,CTNNB1,NFKB1,ZEB2,CXCR4,FYN,STAT3,VIM,LDHB,MALAT1,TSPYL2	CD8+ T cells	GSE199333_post	GSE199333	post	160
Regulation by the Disease Microenvironment	0.21	0.21	821	186	9	23467	BCL2L1,CCNB1,EZH2,HMGB3,MTDH,QKI,HNRNPA2B1,VIM,LDHB	Erythrocytes	GSE199333_post	GSE199333	post	161
Regulation by the Disease Microenvironment	0.14	0.14	1059	186	12	23467	BRAF,CTNNB1,NFKB1,PARP1,TGFB1,ZEB2,CX3CR1,HNRNPA2B1,STAT3,VIM,LDHB,TSPYL2	NK cells	GSE199333_post	GSE199333	post	162
Unusual Activation of Pro-survival Pathway	2.1e-24	1.1e-23	848	781	93	23467	ANXA2,AREG,BCL11A,BRAF,CCND2,CTNNB1,DNMT1,DUSP6,GSTP1,HIF1A,HMGA1,HOXB3,EIF4G1,JUN,PKM,MEF2D,NFKB1,PARP1,KRAS,RHOA,S100A4,SELENOW,SOCS2,STMN1,TYMS,ZEB2,YWHAZ,SLC25A5,ANXA1,BID,BRD4,CD44,HSPD1,CLTC,CLU,CYLD,DDIT3,DUSP1,EIF3A,HSP90B1,EZR,FLT3,GRB2,HNRNPU,HSPA8,HSPB1,HOXA5,NFKBIA,CXCL8,ITGA5,TCF4,LASP1,LDHA,LRRFIP1,MTDH,MAP3K1,MAP3K8,NCOA3,NUCKS1,PABPC1,POMP,PRKDC,PTPN1,RAB14,RAC1,RAP1A,RAP1B,RASSF1,RICTOR,RSF1,S100A11,SFPQ,SMAD3,SMC4,RBPJ,YY1,UCP2,ZBTB7A,ENO1,GNAS,CALR,CSF3R,GNAQ,EIF4EBP1,IL2RA,MDK,REL,RELB,QPRT,ACAP2,TNFAIP8,UBR5,HSH2D	Malignant cells	GSE199333_pre	GSE199333	pre	163
Drug Inactivation by Structure Modification	0.63	1	848	27	1	23467	GSTP1	Malignant cells	GSE199333_pre	GSE199333	pre	164
Aberration of the Drug's Therapeutic Target	0.84	1	848	90	2	23467	BRAF,FLT3	Malignant cells	GSE199333_pre	GSE199333	pre	165
Epigenetic Alteration of DNA, RNA or Protein	0.94	1	848	455	11	23467	BRAF,DNMT1,LMNA,TYMS,CXCL8,MAP3K8,RASSF1,SMC4,TIMP1,MALAT1,GDI2	Malignant cells	GSE199333_pre	GSE199333	pre	166
Irregularity in Drug Uptake and Drug Efflux	1	1	848	37	0	23467		Malignant cells	GSE199333_pre	GSE199333	pre	167
Regulation by the Disease Microenvironment	0.37	0.37	504	186	5	23467	PARP1,ZEB2,HNRNPA2B1,LDHB,MALAT1	B cells	GSE199333_pre	GSE199333	pre	168
Regulation by the Disease Microenvironment	0.34	0.34	151	186	2	23467	CXCR4,SOCS3	CD4+ T cells	GSE199333_pre	GSE199333	pre	169
Regulation by the Disease Microenvironment	0.97	0.97	447	186	1	23467	CXCR4	CD8+ T cells	GSE199333_pre	GSE199333	pre	170
Regulation by the Disease Microenvironment	0.91	0.91	295	186	1	23467	LDHB	Erythrocytes	GSE199333_pre	GSE199333	pre	171
Regulation by the Disease Microenvironment	0.36	0.36	158	186	2	23467	CXCR4,VIM	NK cells	GSE199333_pre	GSE199333	pre	172
Unusual Activation of Pro-survival Pathway	0.026	0.13	127	781	9	23467	JUN,S100A4,BTG1,CXCR4,FTL,GAPDH,TCF4,HNRNPA1,TPT1	Malignant cells	GSE111014_post	GSE111014	post	173
Epigenetic Alteration of DNA, RNA or Protein	0.23	0.58	127	455	4	23467	CXCR4,GAPDH,MALAT1,GABPB1-AS1	Malignant cells	GSE111014_post	GSE111014	post	174
Aberration of the Drug's Therapeutic Target	1	1	127	90	0	23467		Malignant cells	GSE111014_post	GSE111014	post	175
Drug Inactivation by Structure Modification	1	1	127	27	0	23467		Malignant cells	GSE111014_post	GSE111014	post	176
Irregularity in Drug Uptake and Drug Efflux	1	1	127	37	0	23467		Malignant cells	GSE111014_post	GSE111014	post	177
Regulation by the Disease Microenvironment	1	1	57	186	0	23467	NA	CD4+ T cells	GSE111014_post	GSE111014	post	178
Regulation by the Disease Microenvironment	0.21	0.21	197	186	3	23467	ZEB2,FYN,MALAT1	CD8+ T cells	GSE111014_post	GSE111014	post	179
Regulation by the Disease Microenvironment	1	1	19	186	0	23467	NA	Mono_Macro	GSE111014_post	GSE111014	post	180
Regulation by the Disease Microenvironment	0.6	0.6	256	186	2	23467	HNRNPA2B1,MALAT1	NK cells	GSE111014_post	GSE111014	post	181
Unusual Activation of Pro-survival Pathway	0.0032	0.016	222	781	16	23467	ANXA2,GSTP1,JUN,S100A4,BTG1,CXCR4,DUSP1,FTL,FUS,GAPDH,GRB2,ITGB1,HNRNPA1,TPT1,UCP2,CALR	Malignant cells	GSE111014_pre	GSE111014	pre	182
Epigenetic Alteration of DNA, RNA or Protein	0.14	0.35	222	455	7	23467	EIF4G2,CXCR4,GAPDH,MALAT1,PPP1R15A,MT-CO2,GABPB1-AS1	Malignant cells	GSE111014_pre	GSE111014	pre	183
Drug Inactivation by Structure Modification	0.23	0.38	222	27	1	23467	GSTP1	Malignant cells	GSE111014_pre	GSE111014	pre	184
Aberration of the Drug's Therapeutic Target	1	1	222	90	0	23467		Malignant cells	GSE111014_pre	GSE111014	pre	185
Irregularity in Drug Uptake and Drug Efflux	1	1	222	37	0	23467		Malignant cells	GSE111014_pre	GSE111014	pre	186
Regulation by the Disease Microenvironment	0.11	0.11	148	186	3	23467	GATA3,VIM,MALAT1	CD4+ T cells	GSE111014_pre	GSE111014	pre	187
Regulation by the Disease Microenvironment	0.011	0.011	168	186	5	23467	TGFB1,ZEB2,FYN,HNRNPA2B1,MALAT1	CD8+ T cells	GSE111014_pre	GSE111014	pre	188
Regulation by the Disease Microenvironment	0.3	0.3	44	186	1	23467	MALAT1	Mono_Macro	GSE111014_pre	GSE111014	pre	189
Regulation by the Disease Microenvironment	0.19	0.19	27	186	1	23467	MALAT1	NK cells	GSE111014_pre	GSE111014	pre	190
Unusual Activation of Pro-survival Pathway	3.5e-13	1.7e-12	1868	781	122	23467	ATG5,AURKA,BAX,BCAT1,BIRC5,CTSL,CDCP1,CDK4,CDKN1A,CFLAR,CIAPIN1,DCTD,DUSP6,FADD,HMGA1,HMGB1,ID1,IFI27,IL6,ISG15,JUN,MAGEA6,MAGEA12,MYC,NFKB1,PARP1,PPARG,SHC1,SOX9,SPRY2,STMN1,TGFB1,PBK,TYMS,SLC25A5,AIFM1,AKAP12,AR,ANXA1,ATG3,BAG1,BID,HSPA5,CASP1,CAV2,CCNA2,CCNB1,CDK1,CCND1,HSPD1,COL1A1,CUL4A,DDIT3,DKK1,EGR1,HSP90B1,EPHA2,FN1,FTL,GAPDH,G6PD,GCLM,HAX1,HMGB2,HMGN5,HSPA8,EIF4A1,EIF4A3,EIF4E,NFKBIA,ITGA5,LASP1,LDHA,LRRFIP1,MTDH,MXD4,MAGEA3,MAPK3,MAP2K2,MYBL2,NQO1,PIK3R1,PDCD10,PGK1,AGPAT2,PLK1,POMP,PSMB5,PSMG2,RAP1B,RAB27A,RRM1,S100A11,SDC2,SDHB,SMC4,SOCS3,SOD2,SRSF2,TPT1,TFAM,TMED3,TNFAIP3,UBE2C,AXL,WLS,XRCC4,ENO1,GNAS,CD33,NPM1,IL7R,EIF4EBP1,RCN1,RELB,BRD2,PMVK,EBP,NUPR1,TRIB3,WTAP,ACAT2	Malignant cells	GSE131984_JQ1	GSE131984_JQ1	NA	191
Drug Inactivation by Structure Modification	0.16	0.41	1868	27	4	23467	CES1,SOD2,CDA,NME1	Malignant cells	GSE131984_JQ1	GSE131984_JQ1	NA	192
Aberration of the Drug's Therapeutic Target	0.73	1	1868	90	6	23467	CDK4,AR,MAP2K2,NPM1,COMT,AKR1B1	Malignant cells	GSE131984_JQ1	GSE131984_JQ1	NA	193
Irregularity in Drug Uptake and Drug Efflux	0.81	1	1868	37	2	23467	SLC3A2,ABCE1	Malignant cells	GSE131984_JQ1	GSE131984_JQ1	NA	194
Epigenetic Alteration of DNA, RNA or Protein	1	1	1868	455	15	23467	ATG5,H2AFY,IL6,PPARG,SPRY2,TRIP6,TYMS,PMAIP1,GAPDH,MAPK3,SMC4,MALAT1,GDI2,PPP1R15A,MT-CO2	Malignant cells	GSE131984_JQ1	GSE131984_JQ1	NA	195
Unusual Activation of Pro-survival Pathway	3.3e-16	1.7e-15	1949	781	134	23467	ATG5,AURKA,BAX,BCAT1,BIRC5,CTSL,CDCP1,CDK4,CDKN1A,CERS2,CFLAR,CIAPIN1,DCTD,FADD,HMGA1,HMGB1,ID1,IFI27,IL6,ISG15,MAGEA6,MAGEA12,MCL1,MYC,PDGFRA,PPARG,SHC1,ST3GAL4,SOX4,SOX9,SPRY2,STMN1,TGFB1,PBK,TYMS,VOPP1,XIAP,SLC25A5,AIFM1,AKAP12,AR,ANXA1,ATG3,BAD,BAG1,BID,HSPA5,BRD7,CASP1,CAV2,CCNA2,CCNB1,CDK1,HSPD1,COL1A1,CRIM1,DKK1,EGR1,EIF3A,HSP90B1,EZH2,EZR,FN1,FTL,GAPDH,G6PD,GAS6,GRB2,GCLM,HAX1,HMGN5,HNRNPU,EIF4A3,EIF4E,NFKBIA,IL18,KLF4,RPS6KA3,LAMP2,LDHA,LRRFIP1,MTDH,MXD4,MAGEA3,MAPK3,MAP2K2,MYBL2,IKBKG,NQO1,PIK3R1,PDCD10,PGK1,AGPAT2,PLK1,POMP,PSMB5,RAP1B,HRAS,NRAS,RAB27A,RRM1,RND3,S100A11,SDHB,SIAH2,SMC4,SOD2,SRSF2,TPT1,TFAM,TMED3,TNFAIP3,YY1,UBE2C,AXL,WLS,ENO1,IDH3A,GNAS,CD33,ARAF,NPM1,IL7R,EIF4EBP1,IDI1,RCN1,RELB,SQLE,PMVK,EBP,NUPR1,TRIB3,WTAP,ACAT2	Malignant cells	GSE131984_JQ1Pac	GSE131984_JQ1Pac	NA	196
Irregularity in Drug Uptake and Drug Efflux	0.082	0.21	1949	37	6	23467	SLC3A2,ABCF2,ABCE1,SLC7A5,TAP1,SLC7A11	Malignant cells	GSE131984_JQ1Pac	GSE131984_JQ1Pac	NA	197
Drug Inactivation by Structure Modification	0.18	0.3	1949	27	4	23467	CES1,SOD2,CDA,NME1	Malignant cells	GSE131984_JQ1Pac	GSE131984_JQ1Pac	NA	198
Aberration of the Drug's Therapeutic Target	0.47	0.59	1949	90	8	23467	CDK4,PDGFRA,AR,EZH2,MAP2K2,NPM1,COMT,AKR1B1	Malignant cells	GSE131984_JQ1Pac	GSE131984_JQ1Pac	NA	199
Epigenetic Alteration of DNA, RNA or Protein	1	1	1949	455	17	23467	ATG5,H2AFY,IL6,PPARG,SPRY2,TRIP6,TYMS,XIAP,PMAIP1,EZH2,GAPDH,MAPK3,SMC4,TIMP1,MALAT1,GDI2,PPP1R15A	Malignant cells	GSE131984_JQ1Pac	GSE131984_JQ1Pac	NA	200
Unusual Activation of Pro-survival Pathway	3.3e-23	1.7e-22	2427	781	174	23467	ADAM10,ATG5,AURKA,BAX,BBC3,BCAT1,BIRC5,CTSL,CDCP1,CDK4,CFLAR,CIAPIN1,DCTD,DUSP6,EGFR,EPAS1,FADD,FBXW7,FUBP1,GLS,HMGA1,HMGB1,HMOX1,IFI27,ISG15,JUN,MAGEA6,MAGEA12,MCL1,MET,MYC,PARP1,PPARG,RHOA,S100A4,SHC1,SOX4,SOX9,SPRY2,STMN1,TGFB1,TGFBR2,PBK,TYMS,AAMDC,SLC25A5,AIFM1,AR,ANXA1,TFAP2A,ATG3,ATM,BID,HSPA5,BRD7,CASP1,CAV2,CCNA2,CCNB1,CDK1,CCND1,CD44,HSPD1,COL1A1,CRIM1,CUL4A,DDIT3,HSP90B1,EPHA2,EREG,EZH2,EZR,FAT1,FN1,FIS1,FOXO3,FTL,FUS,FYN,G6PD,GAS6,GRB2,HAX1,HDAC3,HIPK2,HMGB2,HMGN5,HNRNPU,HSPA8,HSPB1,EIF4A1,EIF4A3,EIF4E,NFKBIA,ITGB1,LASP1,LDHA,LRRFIP1,MTDH,MXD4,MAGEA3,MAPK3,MYBL2,NCOA3,NQO1,NUCKS1,PIK3R1,PDCD10,PDCD4,PGK1,AGPAT2,PLK1,POMP,PSMB5,PSMG2,PTPN1,PTPN12,RAP1A,RAP1B,RAB27A,RRM2,HNRNPA1,ROCK2,S100A11,SDC2,SDHB,SFPQ,SMAD7,SMC4,SMUG1,SOCS3,SOD2,SPIN1,SRSF2,STK4,TFAM,TNFAIP3,TUSC3,UBE2C,USP22,AXL,ULK1,WEE1,WLS,XRCC4,YBX1,ZKSCAN1,ZNF217,ENO1,FASN,PFKL,GNAS,CD33,GNA11,GNAQ,ARAF,NPM1,IL7R,CEBPD,EIF4EBP1,EPHB4,IDI1,INSIG1,PRKCA,RCN1,PMVK,EBP,ACAP2,NUPR1,TRIB3,CERS6,APP,WTAP,ACAT2	Malignant cells	GSE131984_JQ1Pal	GSE131984_JQ1Pal	NA	201
Drug Inactivation by Structure Modification	0.14	0.35	2427	27	5	23467	CES1,SOD2,CDA,NME1,CMPK1	Malignant cells	GSE131984_JQ1Pal	GSE131984_JQ1Pal	NA	202
Irregularity in Drug Uptake and Drug Efflux	0.54	0.74	2427	37	4	23467	SLC3A2,ABCA1,ABCE1,TAP1	Malignant cells	GSE131984_JQ1Pal	GSE131984_JQ1Pal	NA	203
Aberration of the Drug's Therapeutic Target	0.59	0.74	2427	90	9	23467	CDK4,EGFR,MET,AR,EZH2,GNA11,NPM1,COMT,AKR1B1	Malignant cells	GSE131984_JQ1Pal	GSE131984_JQ1Pal	NA	204
Epigenetic Alteration of DNA, RNA or Protein	1	1	2427	455	21	23467	ATG5,EGFR,FBXW7,H2AFY,LMNA,MET,PPARG,SPRY2,TRIP6,TYMS,PMAIP1,EZH2,FOXO3,MAPK3,PDCD4,SMC4,MALAT1,GDI2,PPP1R15A,MT-CO2,NABP1	Malignant cells	GSE131984_JQ1Pal	GSE131984_JQ1Pal	NA	205
Unusual Activation of Pro-survival Pathway	1.1e-09	5.5e-09	870	781	65	23467	AURKA,BBC3,BIRC5,CDK4,CFLAR,DNMT1,FADD,HMGA1,ID1,IFI27,IL6,ISG15,JUN,MAP1LC3B,PDGFRA,S100A4,STMN1,TIMP3,SLC25A5,ANXA1,BAG1,BTG1,CCND1,CCNG1,HSPD1,COL1A1,DKK1,DUSP1,EGR1,EIF3A,FUS,HNRNPU,HSPA8,HSPB1,IDH1,EIF4E,NFKBIA,IL18,LAMP2,MTDH,MAP3K8,MXD4,NF2,MYO10,PLK1,HRAS,RRM2,S100A11,SFPQ,SMC4,SOD2,TFAM,TMED3,TNFAIP3,TOP1,UBE2C,FASN,CEBPD,IDI1,INSIG1,SPHK1,SAFB2,EBP,NUPR1,ACAT2	Malignant cells	GSE131984_Pac	GSE131984_Pac	NA	206
Irregularity in Drug Uptake and Drug Efflux	0.047	0.12	870	37	4	23467	ABCF2,ABCE1,SLC7A5,SLC29A1	Malignant cells	GSE131984_Pac	GSE131984_Pac	NA	207
Drug Inactivation by Structure Modification	0.077	0.13	870	27	3	23467	SOD2,CDA,NME1	Malignant cells	GSE131984_Pac	GSE131984_Pac	NA	208
Aberration of the Drug's Therapeutic Target	0.24	0.3	870	90	5	23467	CDK4,PDGFRA,IDH1,MAOA,AKR1B1	Malignant cells	GSE131984_Pac	GSE131984_Pac	NA	209
Epigenetic Alteration of DNA, RNA or Protein	0.95	0.95	870	455	11	23467	DNMT1,EIF4G2,IL6,PMAIP1,IDH1,MAP3K8,SMC4,TIMP1,MALAT1,PPP1R15A,DLEU1	Malignant cells	GSE131984_Pac	GSE131984_Pac	NA	210
Unusual Activation of Pro-survival Pathway	1.1e-16	5.6e-16	1570	781	117	23467	ABL1,ANXA2,ATG5,AURKA,BAX,BIRC5,CDK4,CIAPIN1,DNMT1,DUSP6,EPAS1,FADD,HIF1A,HMGA1,HMGB1,IL6,PKM,MCL1,MEF2D,MUC1,MYC,PARP1,PDGFRA,RHOA,S100A4,SHC1,STMN1,TGFBR2,PBK,TYMS,VEGFA,SLC25A5,AIFM1,AKAP12,ANXA1,ATG3,BAG1,HSPA5,BRD7,CAV2,CCNA2,CCNB1,CDK1,CCND1,CCNG2,CD44,HSPD1,COL1A1,CSF1,DKK1,DUSP1,DUSP2,EGR1,HSP90B1,ERRFI1,EZH2,EZR,FN1,FOXO3,FUS,GRB2,GCLM,HAX1,HIPK2,HMGB2,HMGN5,HSPA8,EIF4A3,EIF4E,NFKBIA,ITGA5,ITGB1,LDHA,LRRFIP1,MTDH,MXD4,MAGEA3,MYBL2,PIK3R1,PDCD10,PDCD4,PGK1,AGPAT2,PLK1,POMP,PSMB5,RAC1,RAP1B,HRAS,RRM1,RRM2,S100A11,SDHB,SMC4,SOD2,SRSF2,STAT3,TFAM,TNFAIP3,UBE2C,USP22,ZKSCAN1,ENO1,FASN,IDH3A,GNAS,NPM1,CEBPD,EIF4EBP1,IDI1,INSIG1,SQLE,PMVK,EBP,TRIB3,APP,ACAT2	Malignant cells	GSE131984_Pal	GSE131984_Pal	NA	211
Drug Inactivation by Structure Modification	0.27	0.67	1570	27	3	23467	SOD2,CDA,NME1	Malignant cells	GSE131984_Pal	GSE131984_Pal	NA	212
Irregularity in Drug Uptake and Drug Efflux	0.45	0.7	1570	37	3	23467	SLC3A2,ABCA1,ABCE1	Malignant cells	GSE131984_Pal	GSE131984_Pal	NA	213
Aberration of the Drug's Therapeutic Target	0.56	0.7	1570	90	6	23467	ABL1,CDK4,PDGFRA,EZH2,NPM1,MAOA	Malignant cells	GSE131984_Pal	GSE131984_Pal	NA	214
Epigenetic Alteration of DNA, RNA or Protein	1	1	1570	455	17	23467	ABL1,ATG5,DNMT1,H2AFY,IL6,LMNA,TYMS,PMAIP1,EZH2,FOXO3,PDCD4,SMC4,MALAT1,GDI2,PPP1R15A,MT-CO2,NABP1	Malignant cells	GSE131984_Pal	GSE131984_Pal	NA	215
Unusual Activation of Pro-survival Pathway	1.2e-06	6.2e-06	101	781	15	23467	CFLAR,ID1,JUN,PKM,S100A4,YWHAZ,BTG1,DUSP1,DUSP2,EGR1,ETS1,GAPDH,LDHA,PGK1,ENO1	Malignant cells	GSE150930	GSE150930	NA	216
Epigenetic Alteration of DNA, RNA or Protein	0.86	1	101	455	1	23467	GAPDH	Malignant cells	GSE150930	GSE150930	NA	217
Aberration of the Drug's Therapeutic Target	1	1	101	90	0	23467		Malignant cells	GSE150930	GSE150930	NA	218
Drug Inactivation by Structure Modification	1	1	101	27	0	23467		Malignant cells	GSE150930	GSE150930	NA	219
Irregularity in Drug Uptake and Drug Efflux	1	1	101	37	0	23467		Malignant cells	GSE150930	GSE150930	NA	220
Regulation by the Disease Microenvironment	1	1	2	186	0	23467	NA	CD4+ T cells	GSE150930	GSE150930	NA	221
Regulation by the Disease Microenvironment	1	1	8	186	0	23467	NA	Mono_Macro	GSE150930	GSE150930	NA	222
Unusual Activation of Pro-survival Pathway	5.2e-14	2.6e-13	146	781	28	23467	BIRC5,DNMT1,HMGA1,HMGB1,PKM,RPS6,STMN1,TYMS,ANXA1,BTG1,CDK1,DHFR,GAPDH,HMGB2,HNRNPU,KIF11,LDHA,MDM4,NUCKS1,PGK1,RRM1,RRM2,SMC4,SRSF2,UBE2C,YBX1,ENO1,NPM1	Malignant cells	GSE158457	GSE158457	NA	223
Aberration of the Drug's Therapeutic Target	0.019	0.047	146	90	3	23467	DHFR,NPM1,TOP2A	Malignant cells	GSE158457	GSE158457	NA	224
Epigenetic Alteration of DNA, RNA or Protein	0.15	0.26	146	455	5	23467	DNMT1,TYMS,GAPDH,SMC4,MALAT1	Malignant cells	GSE158457	GSE158457	NA	225
Drug Inactivation by Structure Modification	1	1	146	27	0	23467		Malignant cells	GSE158457	GSE158457	NA	226
Irregularity in Drug Uptake and Drug Efflux	1	1	146	37	0	23467		Malignant cells	GSE158457	GSE158457	NA	227
Unusual Activation of Pro-survival Pathway	2.8e-05	0.00014	194	781	19	23467	CFLAR,GSTP1,RPS6,S100A4,STMN1,SLC25A5,HSPD1,GAPDH,HMGB2,HSPB1,LDHA,PABPC1,S100A11,SMC4,TPT1,YBX1,ENO1,GNAS,NPM1	Malignant cells	GSE161195_post	GSE161195	post	228
Drug Inactivation by Structure Modification	0.021	0.052	194	27	2	23467	GSTP1,NME1	Malignant cells	GSE161195_post	GSE161195	post	229
Aberration of the Drug's Therapeutic Target	0.53	0.88	194	90	1	23467	NPM1	Malignant cells	GSE161195_post	GSE161195	post	230
Epigenetic Alteration of DNA, RNA or Protein	0.73	0.91	194	455	3	23467	GAPDH,SMC4,MALAT1	Malignant cells	GSE161195_post	GSE161195	post	231
Irregularity in Drug Uptake and Drug Efflux	1	1	194	37	0	23467		Malignant cells	GSE161195_post	GSE161195	post	232
Unusual Activation of Pro-survival Pathway	1.1e-05	5.5e-05	120	781	15	23467	ANXA2,DUSP6,ISG15,JUN,MCL1,RPS6,S100A4,CLU,NFKBIA,IL1B,S100A11,SOD2,TPT1,NPM1,CEBPD	Malignant cells	GSE162117_post	GSE162117	post	233
Aberration of the Drug's Therapeutic Target	0.078	0.19	120	90	2	23467	IL1B,NPM1	Malignant cells	GSE162117_post	GSE162117	post	234
Drug Inactivation by Structure Modification	0.13	0.22	120	27	1	23467	SOD2	Malignant cells	GSE162117_post	GSE162117	post	235
Epigenetic Alteration of DNA, RNA or Protein	1	1	120	455	0	23467		Malignant cells	GSE162117_post	GSE162117	post	236
Irregularity in Drug Uptake and Drug Efflux	1	1	120	37	0	23467		Malignant cells	GSE162117_post	GSE162117	post	237
Regulation by the Disease Microenvironment	0.5	0.5	87	186	1	23467	CXCR4	CD4+ T cells	GSE162117_post	GSE162117	post	238
Regulation by the Disease Microenvironment	0.26	0.26	38	186	1	23467	MALAT1	CD8+ T cells	GSE162117_post	GSE162117	post	239
Regulation by the Disease Microenvironment	0.072	0.072	197	186	4	23467	CXCR4,IL1B,VIM,MALAT1	cDCs	GSE162117_post	GSE162117	post	240
Regulation by the Disease Microenvironment	1	1	86	186	0	23467	NA	Erythrocytes	GSE162117_post	GSE162117	post	241
Regulation by the Disease Microenvironment	1	1	23	186	0	23467	NA	NK cells	GSE162117_post	GSE162117	post	242
Regulation by the Disease Microenvironment	1	1	10	186	0	23467	NA	pDCs	GSE162117_post	GSE162117	post	243
Unusual Activation of Pro-survival Pathway	8.4e-09	4.2e-08	239	781	28	23467	ANXA2,CDK6,GSTP1,ISG15,JUN,MCL1,MAP1LC3B,RPS6,S100A4,SOX4,HSPA5,BTG1,CD44,CLU,CXCR4,DUSP1,EGR1,GAPDH,NFKBIA,IL1B,MAP3K8,RAC1,HNRNPA1,S100A8,S100A11,SOD2,TNFAIP3,NPM1	Malignant cells	GSE162117_pre	GSE162117	pre	244
Drug Inactivation by Structure Modification	0.031	0.077	239	27	2	23467	GSTP1,SOD2	Malignant cells	GSE162117_pre	GSE162117	pre	245
Aberration of the Drug's Therapeutic Target	0.064	0.11	239	90	3	23467	CDK6,IL1B,NPM1	Malignant cells	GSE162117_pre	GSE162117	pre	246
Epigenetic Alteration of DNA, RNA or Protein	0.49	0.62	239	455	5	23467	LMNA,CXCR4,GAPDH,MAP3K8,TIMP1	Malignant cells	GSE162117_pre	GSE162117	pre	247
Irregularity in Drug Uptake and Drug Efflux	1	1	239	37	0	23467		Malignant cells	GSE162117_pre	GSE162117	pre	248
Regulation by the Disease Microenvironment	1	1	14	186	0	23467	NA	B cells	GSE162117_pre	GSE162117	pre	249
Regulation by the Disease Microenvironment	1	1	31	186	0	23467	NA	CD4+ T cells	GSE162117_pre	GSE162117	pre	250
Regulation by the Disease Microenvironment	1	1	40	186	0	23467	NA	CD8+ T cells	GSE162117_pre	GSE162117	pre	251
Regulation by the Disease Microenvironment	1	1	29	186	0	23467	NA	cDCs	GSE162117_pre	GSE162117	pre	252
Regulation by the Disease Microenvironment	1	1	20	186	0	23467	NA	Erythrocytes	GSE162117_pre	GSE162117	pre	253
Regulation by the Disease Microenvironment	1	1	38	186	0	23467	NA	NK cells	GSE162117_pre	GSE162117	pre	254
Unusual Activation of Pro-survival Pathway	1.4e-14	7.1e-14	355	781	45	23467	ANXA2,AREG,ATG12,BAX,BIK,CDKN1A,HMGA1,HMGA2,ID1,PKM,NFE2L2,NFKB1,PPARG,S100A4,STMN1,AKAP12,ANXA1,BAD,CAV2,CCN1,CCND1,HSPD1,DKK1,EPHA2,HMGB2,HSPB1,IL1B,IL24,LDHA,MAGEA3,NF2,NQO1,PGK1,ERBB3,S100A11,SOX10,UBE2C,AXL,YBX1,ENO1,GNAS,NPM1,EIF4EBP1,MDK,TRIB3	Malignant cells	GSE164897_Vem	GSE164897_Vem	NA	255
Aberration of the Drug's Therapeutic Target	0.16	0.39	355	90	3	23467	IL1B,NPM1,AKR1B1	Malignant cells	GSE164897_Vem	GSE164897_Vem	NA	256
Epigenetic Alteration of DNA, RNA or Protein	0.54	0.89	355	455	7	23467	BIK,LMNA,PPARG,PMAIP1,TIMP1,CYTOR,MALAT1	Malignant cells	GSE164897_Vem	GSE164897_Vem	NA	257
Drug Inactivation by Structure Modification	1	1	355	27	0	23467		Malignant cells	GSE164897_Vem	GSE164897_Vem	NA	258
Irregularity in Drug Uptake and Drug Efflux	1	1	355	37	0	23467		Malignant cells	GSE164897_Vem	GSE164897_Vem	NA	259
Unusual Activation of Pro-survival Pathway	2.9e-07	1.5e-06	1733	781	97	23467	AURKA,BAX,BRCA1,CDCP1,CDK4,COL3A1,CTNNB1,DCTD,DNMT1,GSTP1,HMGA1,HMGB1,ID1,IRS1,PKM,MCL1,MAP1LC3B,NFE2L2,NFKB1,PARP1,RPS6,S100A4,SHC1,ST3GAL4,SOX4,PBK,YWHAZ,AAMDC,SLC25A5,ATG3,BAD,BAG1,BID,HSPA5,BRD4,BTG1,CCNB1,CDK1,CCND1,CD44,DDIT3,DKK1,EGR1,ERCC1,ERRFI1,FIS1,FOXM1,FTL,FUS,GAPDH,HDAC3,HMGB2,HSPA8,HSPB1,IL24,CXCL8,NKIRAS2,LDHA,MTDH,MGMT,SPP1,PABPC1,PGK1,AGPAT2,POMP,PRKDC,PSMB5,PSMG2,PTPN12,RAC1,RAP1B,ERBB3,HNRNPA1,RSF1,S100A11,SDHB,SMC4,SMUG1,SOX10,TPT1,TFAM,TGFA,TMED3,TMEM54,TOP1,WNT5A,YEATS4,MAGEA4,CALR,NPM1,EIF4EBP1,MDK,RCN1,PMVK,EBP,TRIB3,BIRC2	Malignant cells	GSE164897_VemCob	GSE164897_VemCob	NA	260
Drug Inactivation by Structure Modification	0.32	0.8	1733	27	3	23467	GSTP1,GSS,NME1	Malignant cells	GSE164897_VemCob	GSE164897_VemCob	NA	261
Aberration of the Drug's Therapeutic Target	0.66	0.96	1733	90	6	23467	BRCA1,CDK4,NPM1,COMT,AKR1B1,TOP2A	Malignant cells	GSE164897_VemCob	GSE164897_VemCob	NA	262
Irregularity in Drug Uptake and Drug Efflux	0.77	0.96	1733	37	2	23467	SLC3A2,SLC7A5	Malignant cells	GSE164897_VemCob	GSE164897_VemCob	NA	263
Epigenetic Alteration of DNA, RNA or Protein	1	1	1733	455	14	23467	DNMT1,IRS1,LMNA,TRIP6,PMAIP1,GAPDH,CXCL8,SMC4,TIMP1,CYTOR,MALAT1,GIHCG,GDI2,PPP1R15A	Malignant cells	GSE164897_VemCob	GSE164897_VemCob	NA	264
Unusual Activation of Pro-survival Pathway	3.9e-06	2e-05	1480	781	82	23467	BAX,CDK4,CTNNB1,DNMT1,DUSP6,GSTP1,HMGA1,HMGA2,HMGB1,PKM,MAP1LC3B,NFKB1,PARP1,RHOA,S100A4,SHC1,ST3GAL4,SOX4,STMN1,SLC25A5,AKAP12,ALDH1A3,ATG3,BAD,BID,BRD4,CCND1,CD44,HSPD1,CLTC,CAPNS1,DDIT3,EIF3A,HSP90B1,ERCC1,FTL,FUS,GAPDH,NR3C1,HSPA8,HSPB1,EIF4A1,IL24,KDM5B,LDHA,MTDH,MAGEA3,NQO1,PGK1,AGPAT2,POMP,PRKDC,PSMB5,PSMG2,RAC1,RAP1B,ERBB3,RRM2,HNRNPA1,SDHB,SMC4,SRI,SOX10,SRSF2,STAT3,TGFA,TGFB2,TMED3,TMEM54,TOP1,UBE2C,YBX1,ENO1,MAGEA4,GNAS,CALR,NPM1,EIF4EBP1,PPP3CA,PMVK,TRIB3,BIRC2	Malignant cells	GSE164897_VemTra	GSE164897_VemTra	NA	265
Drug Inactivation by Structure Modification	0.24	0.6	1480	27	3	23467	GSTP1,GSS,NME1	Malignant cells	GSE164897_VemTra	GSE164897_VemTra	NA	266
Irregularity in Drug Uptake and Drug Efflux	0.69	1	1480	37	2	23467	SLC3A2,SLC7A5	Malignant cells	GSE164897_VemTra	GSE164897_VemTra	NA	267
Aberration of the Drug's Therapeutic Target	0.83	1	1480	90	4	23467	CDK4,NPM1,COMT,TOP2A	Malignant cells	GSE164897_VemTra	GSE164897_VemTra	NA	268
Epigenetic Alteration of DNA, RNA or Protein	1	1	1480	455	13	23467	DNMT1,EIF4G2,LMNA,TRIP6,PMAIP1,GAPDH,SMC4,TIMP1,MALAT1,GDI2,PPP1R15A,MT-CO2,NORAD	Malignant cells	GSE164897_VemTra	GSE164897_VemTra	NA	269
Unusual Activation of Pro-survival Pathway	3.3e-13	1.7e-12	1256	781	93	23467	PPP2R5A,ADAM10,ADAM9,ADGRV1,BBC3,BRAF,CDK4,CDKN1A,DNMT1,EGFR,FUBP1,HMOX1,JUN,PKM,MAP1LC3B,MYC,PARP1,RALBP1,RPS6,SELENOW,ST3GAL4,SOX4,STMN1,TPD52,TRIM16,ALDH1A3,AR,ATG3,HSPA5,BNIP2,BTG1,CDK1,CCND1,CCNG1,ALCAM,HSPD1,SLC31A1,EHF,EIF3A,HSP90B1,FN1,FOXA1,FTL,FUS,GAPDH,GCLM,GSR,HAX1,HMGN5,HNRNPU,HSPA8,IDH1,EIF4A3,IKBKB,ITGB1,KAT6A,KDM5B,PRKCD,LAMP2,LASP1,LRIG1,MAP1LC3A,NFATC3,NQO1,POMP,PRKDC,PURA,RAP1B,ERBB3,SFPQ,SMC4,SRSF2,TPT1,TMED3,TOP1,TOP2B,USP14,ENO1,FASN,PFKL,SLC16A1,GNAS,CALR,CEBPD,EIF4EBP1,PPP3CA,SQLE,TM7SF2,TNFAIP8,NUPR1,TRIB3,CERS6,ACAT2	Malignant cells	GSE168668	GSE168668	NA	270
Irregularity in Drug Uptake and Drug Efflux	0.046	0.11	1256	37	5	23467	SLC3A2,ABCC1,ABCC4,SLC4A4,SLC7A11	Malignant cells	GSE168668	GSE168668	NA	271
Aberration of the Drug's Therapeutic Target	0.35	0.58	1256	90	6	23467	BRAF,CDK4,EGFR,AR,IDH1,MAOA	Malignant cells	GSE168668	GSE168668	NA	272
Drug Inactivation by Structure Modification	0.77	0.97	1256	27	1	23467	NME1	Malignant cells	GSE168668	GSE168668	NA	273
Epigenetic Alteration of DNA, RNA or Protein	1	1	1256	455	11	23467	BRAF,DNMT1,EGFR,PMAIP1,GAPDH,IDH1,SMC4,MALAT1,GDI2,MT-CO2,GABPB1-AS1	Malignant cells	GSE168668	GSE168668	NA	274
Regulation by the Disease Microenvironment	1	1	37	186	0	23467	NA	B cells	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	275
Regulation by the Disease Microenvironment	0.06	0.06	50	186	2	23467	LDHB,MALAT1	CD4+ T cells	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	276
Regulation by the Disease Microenvironment	0.34	0.34	52	186	1	23467	TGFB1	CD8+ T cells	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	277
Regulation by the Disease Microenvironment	0.21	0.21	108	186	2	23467	HNRNPA2B1,MALAT1	cDCs	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	278
Regulation by the Disease Microenvironment	0.17	0.17	177	186	3	23467	ZEB2,HNRNPA2B1,MALAT1	Mono_Macro	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	279
Regulation by the Disease Microenvironment	0.01	0.01	56	186	3	23467	TGFB1,HNRNPA2B1,MALAT1	NK cells	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	280
Regulation by the Disease Microenvironment	1	1	19	186	0	23467	NA	pDCs	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	281
Regulation by the Disease Microenvironment	1	1	1	186	0	23467	NA	Plasma cells	GSE169246_PacAteBlood_post	GSE169246_PacAteBlood	post	282
Regulation by the Disease Microenvironment	0.19	0.19	27	186	1	23467	CXCR4	B cells	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	283
Regulation by the Disease Microenvironment	0.007	0.007	16	186	2	23467	CXCR4,MALAT1	CD4+ T cells	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	284
Regulation by the Disease Microenvironment	0.056	0.056	48	186	2	23467	CXCR4,MALAT1	CD8+ T cells	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	285
Regulation by the Disease Microenvironment	0.53	0.53	222	186	2	23467	HNRNPA2B1,VIM	cDCs	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	286
Regulation by the Disease Microenvironment	0.016	0.016	186	186	5	23467	ZEB2,CX3CR1,CXCR4,VIM,MALAT1	Mono_Macro	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	287
Regulation by the Disease Microenvironment	0.27	0.27	40	186	1	23467	CXCR4	NK cells	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	288
Regulation by the Disease Microenvironment	1	1	8	186	0	23467	NA	pDCs	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	289
Regulation by the Disease Microenvironment	1	1	3	186	0	23467	NA	Plasma cells	GSE169246_PacAteBlood_pre	GSE169246_PacAteBlood	pre	290
Regulation by the Disease Microenvironment	0.021	0.021	347	186	7	23467	NFKB1,PARP1,PTEN,CCNG2,HNRNPA2B1,SOCS3,LDHB	B cells	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	291
Regulation by the Disease Microenvironment	0.15	0.15	171	186	3	23467	VIM,LDHB,MALAT1	CD4+ T cells	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	292
Regulation by the Disease Microenvironment	0.19	0.19	190	186	3	23467	CXCR4,VIM,MALAT1	CD8+ T cells	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	293
Regulation by the Disease Microenvironment	1	1	29	186	0	23467	NA	Mast cells	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	294
Regulation by the Disease Microenvironment	0.092	0.092	215	186	4	23467	MMP9,HNRNPA2B1,VIM,TIMP2	Mono_Macro	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	295
Regulation by the Disease Microenvironment	0.066	0.066	117	186	3	23467	NFKB1,CXCR4,MALAT1	NK cells	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	296
Regulation by the Disease Microenvironment	1	1	15	186	0	23467	NA	pDCs	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	297
Regulation by the Disease Microenvironment	0.67	0.67	139	186	1	23467	MTDH	Plasma cells	GSE169246_PacAteTissue_post	GSE169246_PacAteTissue	post	298
Regulation by the Disease Microenvironment	0.18	0.18	182	186	3	23467	TGFB1,CXCR4,VIM	B cells	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	299
Regulation by the Disease Microenvironment	0.08	0.08	288	186	5	23467	FYN,GATA3,STAT3,VIM,MALAT1	CD4+ T cells	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	300
Regulation by the Disease Microenvironment	0.2	0.2	195	186	3	23467	NFKB1,FYN,VIM	CD8+ T cells	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	301
Regulation by the Disease Microenvironment	0.21	0.21	29	186	1	23467	MALAT1	Mast cells	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	302
Regulation by the Disease Microenvironment	0.06	0.06	264	186	5	23467	MMP9,IL1B,TGFBR1,VIM,TIMP2	Mono_Macro	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	303
Regulation by the Disease Microenvironment	0.056	0.056	181	186	4	23467	NFKB1,TGFB1,FYN,MALAT1	NK cells	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	304
Regulation by the Disease Microenvironment	1	1	59	186	0	23467	NA	pDCs	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	305
Regulation by the Disease Microenvironment	0.086	0.086	210	186	4	23467	TP53INP1,CXCR4,RHOB,MALAT1	Plasma cells	GSE169246_PacAteTissue_pre	GSE169246_PacAteTissue	pre	306
Regulation by the Disease Microenvironment	0.36	0.36	160	186	2	23467	HNRNPA2B1,MALAT1	B cells	GSE169246_PacBlood_post	GSE169246_PacBlood	post	307
Regulation by the Disease Microenvironment	0.023	0.023	77	186	3	23467	VIM,LDHB,MALAT1	CD4+ T cells	GSE169246_PacBlood_post	GSE169246_PacBlood	post	308
Regulation by the Disease Microenvironment	0.04	0.04	235	186	5	23467	CXCR4,HNRNPA2B1,VIM,LDHB,MALAT1	CD8+ T cells	GSE169246_PacBlood_post	GSE169246_PacBlood	post	309
Regulation by the Disease Microenvironment	0.52	0.52	348	186	3	23467	TGFB1,VIM,MALAT1	cDCs	GSE169246_PacBlood_post	GSE169246_PacBlood	post	310
Regulation by the Disease Microenvironment	0.0055	0.0055	89	186	4	23467	IL1B,RHOB,VIM,MALAT1	Mono_Macro	GSE169246_PacBlood_post	GSE169246_PacBlood	post	311
Regulation by the Disease Microenvironment	0.63	0.63	123	186	1	23467	MALAT1	NK cells	GSE169246_PacBlood_post	GSE169246_PacBlood	post	312
Regulation by the Disease Microenvironment	1	1	1	186	0	23467	NA	pDCs	GSE169246_PacBlood_post	GSE169246_PacBlood	post	313
Regulation by the Disease Microenvironment	0.39	0.39	169	186	2	23467	RHOB,MALAT1	Plasma cells	GSE169246_PacBlood_post	GSE169246_PacBlood	post	314
Regulation by the Disease Microenvironment	0.15	0.15	88	186	2	23467	LDHB,MALAT1	Progenitors	GSE169246_PacBlood_post	GSE169246_PacBlood	post	315
Regulation by the Disease Microenvironment	0.0037	0.0037	384	186	9	23467	BCL2,CDKN1B,NFKB1,TGFBR2,ZEB2,PDCD6IP,HNRNPA2B1,VIM,MALAT1	B cells	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	316
Regulation by the Disease Microenvironment	0.04	0.04	399	186	7	23467	BCL2,CDKN1B,NFKB1,TGFBR2,CXCR4,HNRNPA2B1,MALAT1	CD4+ T cells	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	317
Regulation by the Disease Microenvironment	0.61	0.61	257	186	2	23467	CDKN1B,CXCR4	CD8+ T cells	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	318
Regulation by the Disease Microenvironment	0.29	0.29	454	186	5	23467	NFKB1,TGFBR2,ZEB2,HNRNPA2B1,VIM	cDCs	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	319
Regulation by the Disease Microenvironment	0.14	0.14	442	186	6	23467	TGFB1,TGFBR2,ZEB2,HNRNPA2B1,VIM,MALAT1	Mono_Macro	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	320
Regulation by the Disease Microenvironment	0.15	0.15	548	186	7	23467	CDKN1B,TGFBR2,ZEB2,CX3CR1,PDCD6IP,HNRNPA2B1,STAT3	NK cells	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	321
Regulation by the Disease Microenvironment	0.21	0.21	199	186	3	23467	HNRNPA2B1,SMAD3,TSPYL2	pDCs	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	322
Regulation by the Disease Microenvironment	0.53	0.53	94	186	1	23467	CDKN1B	Plasma cells	GSE169246_PacBlood_pre	GSE169246_PacBlood	pre	323
Regulation by the Disease Microenvironment	0.77	0.77	186	186	1	23467	HNRNPA2B1	B cells	GSE169246_PacTissue_post	GSE169246_PacTissue	post	324
Regulation by the Disease Microenvironment	0.051	0.051	105	186	3	23467	TGFB1,VIM,TSPYL2	CD4+ T cells	GSE169246_PacTissue_post	GSE169246_PacTissue	post	325
Regulation by the Disease Microenvironment	0.26	0.26	124	186	2	23467	CXCR4,TSPYL2	CD8+ T cells	GSE169246_PacTissue_post	GSE169246_PacTissue	post	326
Regulation by the Disease Microenvironment	0.16	0.16	175	186	3	23467	SNAI1,VIM,FBP1	cDCs	GSE169246_PacTissue_post	GSE169246_PacTissue	post	327
Regulation by the Disease Microenvironment	0.1	0.1	224	186	4	23467	NFKB1,SNAI1,VIM,FBP1	Mono_Macro	GSE169246_PacTissue_post	GSE169246_PacTissue	post	328
Regulation by the Disease Microenvironment	0.036	0.036	228	186	5	23467	CXCR4,HNRNPA2B1,STAT3,VIM,TSPYL2	NK cells	GSE169246_PacTissue_post	GSE169246_PacTissue	post	329
Regulation by the Disease Microenvironment	0.015	0.015	24	186	2	23467	VIM,MALAT1	pDCs	GSE169246_PacTissue_post	GSE169246_PacTissue	post	330
Regulation by the Disease Microenvironment	0.46	0.46	77	186	1	23467	VIM	Plasma cells	GSE169246_PacTissue_post	GSE169246_PacTissue	post	331
Regulation by the Disease Microenvironment	0.0056	0.0056	410	186	9	23467	BCL2,BRAF,NFKB1,TGFBR2,ZEB2,CXCR4,RHOB,VIM,MALAT1	B cells	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	332
Regulation by the Disease Microenvironment	0.12	0.12	240	186	4	23467	NFKB1,HNRNPA2B1,LDHB,MALAT1	CD4+ T cells	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	333
Regulation by the Disease Microenvironment	0.12	0.12	329	186	5	23467	BRAF,NFKB1,HNRNPA2B1,MALAT1,TSPYL2	CD8+ T cells	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	334
Regulation by the Disease Microenvironment	1	1	52	186	0	23467	NA	cDCs	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	335
Regulation by the Disease Microenvironment	0.0059	0.0059	270	186	7	23467	MMP9,CXCR4,IL1B,VIM,MALAT1,FBP1,TIMP2	Mono_Macro	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	336
Regulation by the Disease Microenvironment	0.28	0.28	41	186	1	23467	TGFB1	NK cells	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	337
Regulation by the Disease Microenvironment	1	1	9	186	0	23467	NA	pDCs	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	338
Regulation by the Disease Microenvironment	0.14	0.14	254	186	4	23467	CXCR4,HNRNPA2B1,VIM,MALAT1	Plasma cells	GSE169246_PacTissue_pre	GSE169246_PacTissue	pre	339
Unusual Activation of Pro-survival Pathway	2.1e-17	1.1e-16	945	781	86	23467	ADAM10,AREG,BCL2L11,BAX,BCL2,CDKN1A,CDKN1B,DNMT1,FBXW7,GSTP1,HMGB1,ID1,EIF4G1,IFI27,JUN,PKM,MCL1,MAP1LC3B,MYC,PARP1,PTEN,KRAS,RALBP1,RHOA,S100A4,STMN1,TP53INP1,TPD52,TYMS,YWHAZ,SLC25A5,ANXA1,HSPA5,BTG1,CASP8,CCND1,CDKN2A,HSPD1,CXCR4,DDIT3,DUSP1,DUSP2,EGR1,EZH2,EZR,FGFR1,FTL,FUS,GAPDH,NR3C1,GRB2,HMGB2,HNRNPU,HSPA8,EIF4A1,NFKBIA,ITGB1,TCF4,MAP4K3,MDM4,NSD2,NUCKS1,PABPC1,PDCD4,PRKDC,PTPN18,RAC1,RAP1B,RND3,HNRNPA1,SFPQ,SMC4,SMARCC1,SRSF2,TNFAIP3,TOP1,UCP2,WEE1,YBX1,GNAS,NPM1,BRD2,G3BP1,PMVK,QPRT,HSH2D	Malignant cells	GSE189460_pre	GSE189460	pre	340
Aberration of the Drug's Therapeutic Target	0.15	0.39	945	90	6	23467	BCL2,CDKN2A,EZH2,FGFR1,SF3B1,NPM1	Malignant cells	GSE189460_pre	GSE189460	pre	341
Epigenetic Alteration of DNA, RNA or Protein	0.38	0.63	945	455	20	23467	BCL2L11,BCL2,DNMT1,FBXW7,H2AFY,LMNA,TYMS,PMAIP1,ARID4B,CDKN2A,CXCR4,EZH2,GAPDH,PDCD4,SMC4,TIMP1,CYTOR,MALAT1,PPP1R15A,MX1	Malignant cells	GSE189460_pre	GSE189460	pre	342
Drug Inactivation by Structure Modification	0.67	0.78	945	27	1	23467	GSTP1	Malignant cells	GSE189460_pre	GSE189460	pre	343
Irregularity in Drug Uptake and Drug Efflux	0.78	0.78	945	37	1	23467	SLC3A2	Malignant cells	GSE189460_pre	GSE189460	pre	344
Regulation by the Disease Microenvironment	0.35	0.35	54	186	1	23467	RHOB	B cells	GSE189460_pre	GSE189460	pre	345
Regulation by the Disease Microenvironment	1	1	40	186	0	23467	NA	CD4+ T cells	GSE189460_pre	GSE189460	pre	346
Regulation by the Disease Microenvironment	0.19	0.19	190	186	3	23467	TGFB1,CXCR4,TSPYL2	CD8+ T cells	GSE189460_pre	GSE189460	pre	347
Regulation by the Disease Microenvironment	1	1	47	186	0	23467	NA	cDCs	GSE189460_pre	GSE189460	pre	348
Regulation by the Disease Microenvironment	0.87	0.87	255	186	1	23467	EZH2	Erythrocytes	GSE189460_pre	GSE189460	pre	349
Regulation by the Disease Microenvironment	1	1	3	186	0	23467	NA	Fibroblasts	GSE189460_pre	GSE189460	pre	350
Regulation by the Disease Microenvironment	0.019	0.019	194	186	5	23467	VEGFA,CX3CR1,IL1B,RHOB,VIM	Mono_Macro	GSE189460_pre	GSE189460	pre	351
Regulation by the Disease Microenvironment	0.42	0.42	68	186	1	23467	CXCR4	NK cells	GSE189460_pre	GSE189460	pre	352
Regulation by the Disease Microenvironment	1	1	17	186	0	23467	NA	pDCs	GSE189460_pre	GSE189460	pre	353
Regulation by the Disease Microenvironment	1	1	22	186	0	23467	NA	Progenitors	GSE189460_pre	GSE189460	pre	354
Unusual Activation of Pro-survival Pathway	0.0011	0.0053	199	781	16	23467	CDKN1A,GSTP1,SLC2A1,HSPA1A,ID1,YWHAZ,FOXA1,GAPDH,LDHA,LRIG1,NOTCH3,NQO1,RAC1,UCP2,ENO1,ALDH1A1	Malignant cells	GSE207422_Sin_post	GSE207422_Sin	post	355
Drug Inactivation by Structure Modification	0.21	0.45	199	27	1	23467	GSTP1	Malignant cells	GSE207422_Sin_post	GSE207422_Sin	post	356
Irregularity in Drug Uptake and Drug Efflux	0.27	0.45	199	37	1	23467	SLC2A1	Malignant cells	GSE207422_Sin_post	GSE207422_Sin	post	357
Epigenetic Alteration of DNA, RNA or Protein	0.98	1	199	455	1	23467	GAPDH	Malignant cells	GSE207422_Sin_post	GSE207422_Sin	post	358
Aberration of the Drug's Therapeutic Target	1	1	199	90	0	23467		Malignant cells	GSE207422_Sin_post	GSE207422_Sin	post	359
Regulation by the Disease Microenvironment	0.39	0.39	168	186	2	23467	TP53INP1,CXCR4	B cells	GSE207422_Sin_post	GSE207422_Sin	post	360
Regulation by the Disease Microenvironment	0.2	0.2	194	186	3	23467	CXCR4,FYN,SOCS3	CD4+ T cells	GSE207422_Sin_post	GSE207422_Sin	post	361
Regulation by the Disease Microenvironment	0.3	0.3	349	186	4	23467	CXCR4,RHOB,SOCS3,MALAT1	CD8+ T cells	GSE207422_Sin_post	GSE207422_Sin	post	362
Regulation by the Disease Microenvironment	1	1	7	186	0	23467	NA	Fibroblasts	GSE207422_Sin_post	GSE207422_Sin	post	363
Regulation by the Disease Microenvironment	1	1	41	186	0	23467	NA	Mast cells	GSE207422_Sin_post	GSE207422_Sin	post	364
Regulation by the Disease Microenvironment	0.3	0.3	456	186	5	23467	VEGFA,CXCR4,SOCS3,VIM,FBP1	Mono_Macro	GSE207422_Sin_post	GSE207422_Sin	post	365
Regulation by the Disease Microenvironment	0.35	0.35	266	186	3	23467	PAK1,CXCR4,RHOB	Neutrophils	GSE207422_Sin_post	GSE207422_Sin	post	366
Regulation by the Disease Microenvironment	0.019	0.019	27	186	2	23467	CX3CR1,CXCR4	NK cells	GSE207422_Sin_post	GSE207422_Sin	post	367
Regulation by the Disease Microenvironment	0.092	0.092	64	186	2	23467	CX3CR1,CXCR4	pDCs	GSE207422_Sin_post	GSE207422_Sin	post	368
Regulation by the Disease Microenvironment	1	1	58	186	0	23467	NA	Plasma cells	GSE207422_Sin_post	GSE207422_Sin	post	369
Unusual Activation of Pro-survival Pathway	1e-22	5.1e-22	945	781	96	23467	PPP2R5A,ANXA2,AREG,BCL11A,CDKN1A,CERS2,DUSP6,EGFR,GSTP1,SLC2A1,HEY1,HSPA1A,IFI27,ISG15,JUN,PKM,MUC1,MYC,NFE2L2,RAB12,RHOA,RPS6,SOX2,TRIM16,YAP1,SLC25A5,AGR2,ANXA1,NET1,BAG3,HSPA5,ALCAM,CD44,CDKN2A,HSPD1,CLTC,CLU,CAPNS1,CTNND1,DDR1,DUSP1,EGR1,ERRFI1,EZR,FTL,GAPDH,GCLM,GCLC,GSR,HAX1,HBEGF,HSPA8,HK1,NFKBIA,ITGB1,ITGB8,TCF4,AK4,KLF4,LAMP2,LAMP3,LDHA,LRRFIP1,MTDH,NOTCH3,NQO1,NTRK2,TP63,PABPC1,PDCD10,PGK1,POMP,RAB27A,ERBB3,RND3,HNRNPA1,S100A11,TMED3,TMEM54,TNFSF10,TOP1,TUSC3,USP14,WNT5A,ENO1,SLC16A1,CALR,NPM1,CEBPD,DHCR24,GFPT1,INSIG1,BRD2,NKX2-1,FZD7,ALDH1A1	Malignant cells	GSE207422_Tor_post	GSE207422_Tor	post	370
Irregularity in Drug Uptake and Drug Efflux	0.0033	0.0084	945	37	6	23467	SLC2A1,ABCC1,ABCE1,ABCG1,ABCC5,SLC34A2	Malignant cells	GSE207422_Tor_post	GSE207422_Tor	post	371
Drug Inactivation by Structure Modification	0.093	0.16	945	27	3	23467	GSTP1,CES1,CMPK1	Malignant cells	GSE207422_Tor_post	GSE207422_Tor	post	372
Aberration of the Drug's Therapeutic Target	0.3	0.37	945	90	5	23467	EGFR,CDKN2A,NPM1,NECTIN4,LRRK2	Malignant cells	GSE207422_Tor_post	GSE207422_Tor	post	373
Epigenetic Alteration of DNA, RNA or Protein	0.98	0.98	945	455	11	23467	EGFR,H2AFY,LMNA,PMAIP1,CDKN2A,GAPDH,MALAT1,GDI2,PPP1R15A,MT-CO2,MX1	Malignant cells	GSE207422_Tor_post	GSE207422_Tor	post	374
Regulation by the Disease Microenvironment	0.29	0.29	239	186	3	23467	PAK1,CXCR4,MALAT1	B cells	GSE207422_Tor_post	GSE207422_Tor	post	375
Regulation by the Disease Microenvironment	0.018	0.018	126	186	4	23467	CXCR4,JAK3,RHOB,VIM	CD4+ T cells	GSE207422_Tor_post	GSE207422_Tor	post	376
Regulation by the Disease Microenvironment	0.062	0.062	114	186	3	23467	CXCR4,RHOB,VIM	CD8+ T cells	GSE207422_Tor_post	GSE207422_Tor	post	377
Regulation by the Disease Microenvironment	1	1	8	186	0	23467	NA	Endothelial cells	GSE207422_Tor_post	GSE207422_Tor	post	378
Regulation by the Disease Microenvironment	1	1	9	186	0	23467	NA	Fibroblasts	GSE207422_Tor_post	GSE207422_Tor	post	379
Regulation by the Disease Microenvironment	0.041	0.041	238	186	5	23467	VEGFA,CXCR4,IL1B,SOCS3,MALAT1	Mono_Macro	GSE207422_Tor_post	GSE207422_Tor	post	380
Regulation by the Disease Microenvironment	0.019	0.019	193	186	5	23467	PTEN,IL1B,SOCS3,VIM,TIMP2	Neutrophils	GSE207422_Tor_post	GSE207422_Tor	post	381
Regulation by the Disease Microenvironment	0.3	0.3	44	186	1	23467	CXCR4	pDCs	GSE207422_Tor_post	GSE207422_Tor	post	382
Regulation by the Disease Microenvironment	0.023	0.023	76	186	3	23467	TP53INP1,CXCR4,VIM	Plasma cells	GSE207422_Tor_post	GSE207422_Tor	post	383
Regulation by the Disease Microenvironment	0.015	0.015	24	186	2	23467	CXCR4,RHOB	B cells	GSE212217_post	GSE212217	post	384
Regulation by the Disease Microenvironment	1	1	6	186	0	23467	NA	CD4+ T cells	GSE212217_post	GSE212217	post	385
Regulation by the Disease Microenvironment	1	1	8	186	0	23467	NA	CD8+ T cells	GSE212217_post	GSE212217	post	386
Regulation by the Disease Microenvironment	0.13	0.13	18	186	1	23467	CXCR4	cDCs	GSE212217_post	GSE212217	post	387
Regulation by the Disease Microenvironment	0.084	0.084	11	186	1	23467	VIM	Mono_Macro	GSE212217_post	GSE212217	post	388
Regulation by the Disease Microenvironment	0.054	0.054	7	186	1	23467	TGFB1	NK cells	GSE212217_post	GSE212217	post	389
Regulation by the Disease Microenvironment	1	1	5	186	0	23467	NA	pDCs	GSE212217_post	GSE212217	post	390
Regulation by the Disease Microenvironment	1	1	31	186	0	23467	NA	Plasma cells	GSE212217_post	GSE212217	post	391
Regulation by the Disease Microenvironment	1	1	7	186	0	23467	NA	B cells	GSE212217_pre	GSE212217	pre	392
Regulation by the Disease Microenvironment	1	1	11	186	0	23467	NA	CD4+ T cells	GSE212217_pre	GSE212217	pre	393
Regulation by the Disease Microenvironment	0.13	0.13	17	186	1	23467	VIM	CD8+ T cells	GSE212217_pre	GSE212217	pre	394
Regulation by the Disease Microenvironment	0.12	0.12	16	186	1	23467	VIM	cDCs	GSE212217_pre	GSE212217	pre	395
Regulation by the Disease Microenvironment	0.18	0.18	25	186	1	23467	VIM	Mono_Macro	GSE212217_pre	GSE212217	pre	396
Regulation by the Disease Microenvironment	1	1	18	186	0	23467	NA	NK cells	GSE212217_pre	GSE212217	pre	397
Regulation by the Disease Microenvironment	1	1	4	186	0	23467	NA	pDCs	GSE212217_pre	GSE212217	pre	398
Regulation by the Disease Microenvironment	1	1	5	186	0	23467	NA	Plasma cells	GSE212217_pre	GSE212217	pre	399
Regulation by the Disease Microenvironment	0.0084	0.0084	517	186	10	23467	BCL2,CDKN1B,NFKB1,TGFB1,CXCR4,FYN,SOCS3,STAT3,VIM,TSPYL2	CD4+ T cells	PMID34715028_post	PMID34715028	post	400
Regulation by the Disease Microenvironment	4.8e-05	4.8e-05	500	186	14	23467	BCL2,CDKN1B,NFKB1,TGFB1,TGFBR2,CXCR4,FYN,GATA3,RHOB,HNRNPA2B1,SOCS3,STAT3,VIM,TSPYL2	CD8+ T cells	PMID34715028_post	PMID34715028	post	401