Original_dataset	PMID	RawData_ID	Extract_protocol	Data_processing	Title	primay_key
GSE161801	34845188	EGAD00001006903	10x genomics	CellRanger 3.0.1	Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics	1
GSE197268	36097221	phs002922.v1.p1	10x genomics	CellRanger 6.0.1	Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma	2
GSE199333	NA	NA	10x genomics	CellRanger 3.1.0	NA	3
GSE164237	34911739	PRJNA689600	10x genomics	CellRanger 3.1.0	NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy	4
GSE161195	33619369	PRJNA675855	MARS-seq v2.0	NA	Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing	5
GSE164551	33558511	https://doi.org/10.7910/DVN/1RKYQ8	10x genomics	CellRanger 3.1.0	Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma	6
GSE163836	36409824	PRJNA685991	10x genomics	CellRanger	JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States	7
GSE139386	35999456	PRJNA321747	10x genomics	CellRanger	DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor-resistant lung cancer therapy	8
GSE186960	35476525	PRJNA776896	DropSeq and 10x genomics	Casava1.7 and CellRanger 6.0.0	Calcium channel blockers potentiate gemcitabine chemotherapy in pancreatic cancer	9
GSE149214	33712615	PRJNA627676	DropSeq 	Casava1.7	Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer	10
GSE140440	32513898	PRJNA589746	SMART-seq v4	NA	Single-Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells	11
GSE115251	31391581	PRJNA474340	10x genomics	CellRanger	BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells	12
GSE104987	30472020	PRJNA414337	inDrop v3	indrops pipeline	KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance	13
GSE108397	30061114	PRJNA427121	10x genomics	CellRanger 1.3.1	Single-cell RNA-seq analysis identifies markers of resistance to targeted BRAF inhibitors in melanoma cell populations	14
GSE152469	33298182	PRJNA639502	10x genomics	CellRanger 3.0.2	Longitudinal CITE-Seq profiling of chronic lymphocytic leukemia during ibrutinib treatment: evolution of leukemic and immune cells at relapse	15
GSE153697	33558546	PRJNA643723	10x genomics	CellRanger 3.0.1	Longitudinal CITE-Seq profiling of chronic lymphocytic leukemia during ibrutinib treatment: evolution of leukemic and immune cells at relapse	16
GSE175716	34421602	PRJNA733283	BD Rhapsody system	"NovelBio Bio-Pharm Technology Co., Ltd."	Activation of FcRn Mediates a Primary Resistance Response to Sorafenib in Hepatocellular Carcinoma by Single-Cell RNA Sequencing	17
GSE138267	33521652	PRJNA575243	10x genomics	CellRanger 2.0.0	Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer	18
GSE111014	31996669	PRJNA435591	10x genomics	CellRanger 2.0.0 	Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL	19
GSE212217	36301137	PRJNA874603	10x genomics	 CellRanger	Distinct Mechanisms of Mismatch-Repair Deficiency Delineate Two Modes of Response to Anti-PD-1 Immunotherapy in Endometrial Carcinoma	20
GSE169246	34653365	NA	10x genomics	CellRanger 3.0.0	Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer	21
PMID34715028	34715028	EGAD00001008166	10x genomics	CellRanger 5.0.0	Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma	22
GSE207422	36869384	https://ngdc.cncb.ac.cn/gsa-human/browse/HRA001033	BD Rhapsody system	 BD Rhapsody Whole Transcriptome Analysis (WTA) Pipeline	Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing	23
GSE150930	33194728	PRJNA634108	10x genomics	CellRanger	Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report	24
GSE189460	36380017	PRJNA783047	10x genomics	CellRanger 3.0.1	Single-cell analysis of multiple myelomas refines the molecular features of bortezomib treatment responsiveness	25
GSE162117	34514432	PRJNA680611	10x genomics	CellRanger 2.0.1	Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis	26
GSE131984	32393766	PRJNA545508	10x genomics	CellRanger 2.1.0	Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer	27
GSE168668	34489465	PRJNA713356	10x genomics	CellRanger 3.0.2	Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse	28
GSE158457	34151288	PRJNA665257	10x genomics	CellRanger 3.1.0	Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia	29
GSE164897	34591417	PRJNA692421	10x genomics	CellRanger	Single-cell trajectories of melanoma cell resistance to targeted treatment	30