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| Effect of IpA events in splicing factors on alternative splicing |
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Gene: WDR1 |
Summary of IpA events by gene symbol |
 Gene summary. |
| Gene information | Gene Symbol | WDR1 | Gene Synonym | HEL-S-52|AIP1|NORI-1 |
| Gene Description | WD_repeat_domain_1_[Source:HGNC_Symbol;Acc:12754] | |
| Gene Type | protein_coding | |
| IpA ID | chr4:10116856:-WDR1 |
| IpA events based on Gencode V22 structure. |
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| IpA events based on Gencode V22 structure. |
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| IpA events based on Gencode V22 structure. |
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| IpA events based on Gencode V22 structure. |
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Associations of IpA events and isoform expression |
| Gene Symbol | IpA ID | isoform id | r_val | p_val | FDR | Cancer Type | Figure |
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Associations of IpA events and gene expression |
| Gene Symbol | IpA ID | r_val | p_val | FDR | Cancer Type | Figure |
| WDR1 | chr4:10116856:-WDR1 | 7.42e-01 | 1.88e-94 | 5.11e-94 | KIRC | image |
| WDR1 | chr4:10116856:-WDR1 | 8.73e-01 | 2.74e-160 | 1.89e-159 | LUAD | image |
| WDR1 | chr4:10116856:-WDR1 | 8.40e-01 | 8.53e-135 | 4.58e-134 | LUSC | image |
| WDR1 | chr4:10116856:-WDR1 | 7.97e-01 | 2.80e-92 | 8.33e-92 | STAD | image |
| WDR1 | chr4:10116856:-WDR1 | 7.83e-01 | 4.16e-32 | 8.18e-32 | TGCT | image |
| WDR1 | chr4:10116856:-WDR1 | 7.55e-01 | 2.05e-93 | 4.64e-93 | THCA | image |
| WDR1 | chr4:10116856:-WDR1 | 7.47e-01 | 1.70e-100 | 3.50e-100 | UCEC | image |
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Stage-specific differential IpA events |
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| Gene Symbol | IpA ID | StageI_StageII | StageI_StageIII | StageI_StageIV | StageII_StageIII | StageII_StageIV | StageIII_StageIV | Cancer Type | Figure |
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Prognosis-related IpA events |
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| Gene Symbol | IpA ID | Survival p_val | Cancer Type | Figure |
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IpA-regulated miRNA escape |
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| IpA events based on Gencode V22 structure. |
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| IpA events based on Gencode V22 structure. |
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| IpA events based on Gencode V22 structure. |
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| IpA-regulated miRNA escape. |
| IpA ID | Gene Symbol | miRNA Family ID | MSA Start | MSA End | Intron Start | Intron End | Site Type | ORF Overlap |
| Page: 1 |
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Effect of IpA events in splicing factors on alternative splicing |
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| All_IpA_splicing_factor_correlation. |
| IpA ID | Gene Symbol | r_val | p_val | FDR | Event Chr | Alt Region Coordinates | Cancer |
| chr4:10116856:-WDR1 | WDR1 | -0.124 | 0.361 | 0.971 | 4 | 10084801:10084802 | UCS |
| chr4:10116856:-WDR1 | WDR1 | -0.124 | 0.361 | 0.971 | 4 | 10086154:10086170 | UCS |
| chr4:10116856:-WDR1 | WDR1 | -0.124 | 0.361 | 0.971 | 4 | 10089559:10089564 | UCS |
| chr4:10116856:-WDR1 | WDR1 | -0.124 | 0.361 | 0.971 | 4 | 10089563:10089564 | UCS |
| chr4:10116856:-WDR1 | WDR1 | -0.124 | 0.361 | 0.971 | 4 | 10089997:10090156 | UCS |
| chr4:10116856:-WDR1 | WDR1 | -0.124 | 0.361 | 0.971 | 4 | 10099504:10099515 | UCS |
| chr4:10116856:-WDR1 | WDR1 | -0.124 | 0.361 | 0.971 | 4 | 10117853:10117858 | UCS |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10079069:10079072 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10079505:10079550 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10080610:10080625 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10080625:10080663 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10084797:10084802 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10084800:10084802 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10084801:10084802 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10086154:10086170 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10089559:10089564 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10089563:10089564 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10089997:10090156 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10099504:10099515 | UVM |
| chr4:10116856:-WDR1 | WDR1 | -0.112 | 0.325 | 0.926 | 4 | 10117853:10117858 | UVM |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| All_IPA_PSI_QTL. |
| IpA ID | Gene Symbol | splicing_gene | statistic | pvalue | FDR | Beta | Cancer |
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IpA events Quantitative Trait Methylation (IpAQTM) |
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| Gene Symbol | Composite ID | IpA ID | statistic | pvalue | p.adjust | Beta | Cancer |
| WDR1 | cg02542872 | chr4:10116856:-WDR1 | -6.99e+00 | 1.0211651260956e-11 | 0.000474587840290896 | -1.65e+03 | HNSC |
| WDR1 | cg22914057 | chr4:10116856:-WDR1 | -6.97e+00 | 1.13245623279575e-11 | 0.000523444531449217 | -2.80e+02 | PAAD |
| WDR1 | cg02750234 | chr4:10116856:-WDR1 | -6.66e+00 | 6.94825329786463e-11 | 0.00283838183055986 | -1.80e+01 | LGG |
| WDR1 | cg13146379 | chr4:10116856:-WDR1 | -6.55e+00 | 1.37474241870816e-10 | 0.00525979913748637 | -6.21e+00 | BLCA |
| WDR1 | cg15111475 | chr4:10116856:-WDR1 | -6.46e+00 | 2.41472490446858e-10 | 0.00865217931414972 | -1.40e+01 | ACC |
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Effect of IpA events in RBPs on their targets |
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| Gene Symbol | Composite ID | IpA ID | statistic | pvalue | p.adjust | Beta | Cancer |
| WDR1 | cg02542872 | chr4:10116856:-WDR1 | -6.99e+00 | 1.0211651260956e-11 | 0.000474587840290896 | -1.65e+03 | HNSC |
| WDR1 | cg22914057 | chr4:10116856:-WDR1 | -6.97e+00 | 1.13245623279575e-11 | 0.000523444531449217 | -2.80e+02 | PAAD |
| WDR1 | cg02750234 | chr4:10116856:-WDR1 | -6.66e+00 | 6.94825329786463e-11 | 0.00283838183055986 | -1.80e+01 | LGG |
| WDR1 | cg13146379 | chr4:10116856:-WDR1 | -6.55e+00 | 1.37474241870816e-10 | 0.00525979913748637 | -6.21e+00 | BLCA |
| WDR1 | cg15111475 | chr4:10116856:-WDR1 | -6.46e+00 | 2.41472490446858e-10 | 0.00865217931414972 | -1.40e+01 | ACC |
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IpA events dysregulated by SNPs |
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| SNPs_affect_PAS |
| Gene Symbol | IpA ID | rs_id | ref | alt | hexamers_ref | hexamers_alt | snp_affect_pas | variant_position |
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| SNPs_affect_PAS_reverse |
| Gene Symbol | IpA ID | rs_id | ref | alt | hexamers_ref | hexamers_alt | snp_affect_pas | variant_position |
| WDR1 | chr4:10116856:-WDR1 | rs1013348956 | G | A | TTTAAG | TTTAAA | create | chr4:10116856 |
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IpA events associated immune infiltration |
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| IpA ID | Gene Symbol | Immune | r_val | p_val | Cancer |
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IpA events related FDA approved-drugs |
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| Gene Symbol | IpA ID | UniProtAcc | DrugBank ID | Drug name | Drug Activity | Drug Type | Drug Status |
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IpA events contribute to drug resistance |
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| IpA ID | Gene Symbol | Drug | F_stat | p_val |
| chr4:10116856:-WDR1 | WDR1 | AZD2014 | 9.13e+00 | 2.64e-03 |
| chr4:10116856:-WDR1 | WDR1 | CAMPTOTHECIN | 4.30e+00 | 3.85e-02 |
| chr4:10116856:-WDR1 | WDR1 | DASATINIB | 5.66e+00 | 1.78e-02 |
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