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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CDC5L |
 Gene summary |
| Gene information | Gene symbol | CDC5L | Gene ID | 988 |
| Gene name | cell division cycle 5 like | |
| Synonyms | CDC5|CDC5-LIKE|CEF1|PCDC5RP|dJ319D22.1 | |
| Cytomap | 6p21.1 | |
| Type of gene | protein-coding | |
| Description | cell division cycle 5-like proteinCDC5 cell division cycle 5-likeCdc5-related proteindJ319D22.1 (CDC5-like protein)pombe cdc5-related protein | |
| Modification date | 20200313 | |
| UniProtAcc | Q99459, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDC5L | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| CDC5L | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11082045 |
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RNA A-to-I events for CDC5L |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1269041(44449399, +), ADediting_1269042(44449400, +), ADediting_1269043(44449405, +), ADediting_1269044(44449421, +), ADediting_1269045(44449422, +), ADediting_1269046(44449440, +), ADediting_1269047(44449445, +), ADediting_1269048(44449448, +), ADediting_1269049(44449459, +), ADediting_1269050(44449469, +), ADediting_1269051(44449923, +), ADediting_1269052(44449981, +), ADediting_1269053(44449990, +), ADediting_1269054(44450003, +), ADediting_1269055(44450044, +), ADediting_1269056(44450064, +), ADediting_1269057(44450073, +), ADediting_1269058(44450085, +), ADediting_1269059(44450098, +), ADediting_1269060(44450125, +), ADediting_1269061(44450126, +), ADediting_1269062(44450138, +), ADediting_1584123(44429227, +), ADediting_1584124(44449408, +), ADediting_1584125(44450103, +), ADediting_1584126(44450135, +), |
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RNA editing positional annotations for CDC5L using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1269041 | chr6_44449399_+ | UTR3 |
| ADediting_1269042 | chr6_44449400_+ | UTR3 |
| ADediting_1269043 | chr6_44449405_+ | UTR3 |
| ADediting_1269044 | chr6_44449421_+ | UTR3 |
| ADediting_1269045 | chr6_44449422_+ | UTR3 |
| ADediting_1269046 | chr6_44449440_+ | UTR3 |
| ADediting_1269047 | chr6_44449445_+ | UTR3 |
| ADediting_1269048 | chr6_44449448_+ | UTR3 |
| ADediting_1269049 | chr6_44449459_+ | UTR3 |
| ADediting_1269050 | chr6_44449469_+ | UTR3 |
| ADediting_1269051 | chr6_44449923_+ | UTR3 |
| ADediting_1269052 | chr6_44449981_+ | UTR3 |
| ADediting_1269053 | chr6_44449990_+ | UTR3 |
| ADediting_1269054 | chr6_44450003_+ | UTR3 |
| ADediting_1269055 | chr6_44450044_+ | UTR3 |
| ADediting_1269056 | chr6_44450064_+ | UTR3 |
| ADediting_1269057 | chr6_44450073_+ | UTR3 |
| ADediting_1269058 | chr6_44450085_+ | UTR3 |
| ADediting_1269059 | chr6_44450098_+ | UTR3 |
| ADediting_1269060 | chr6_44450125_+ | UTR3 |
| ADediting_1269061 | chr6_44450126_+ | UTR3 |
| ADediting_1269062 | chr6_44450138_+ | UTR3 |
| ADediting_1584123 | chr6_44429227_+ | intronic |
| ADediting_1584124 | chr6_44449408_+ | UTR3 |
| ADediting_1584125 | chr6_44450103_+ | UTR3 |
| ADediting_1584126 | chr6_44450135_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1269041 | chr6_44449399_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269042 | chr6_44449400_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269043 | chr6_44449405_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269044 | chr6_44449421_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269045 | chr6_44449422_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269046 | chr6_44449440_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269047 | chr6_44449445_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269048 | chr6_44449448_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269049 | chr6_44449459_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269050 | chr6_44449469_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1269051 | chr6_44449923_+ | SINE | Alu | Name=AluSx |
| ADediting_1269052 | chr6_44449981_+ | SINE | Alu | Name=AluSx |
| ADediting_1269053 | chr6_44449990_+ | SINE | Alu | Name=AluSx |
| ADediting_1269054 | chr6_44450003_+ | SINE | Alu | Name=AluSx |
| ADediting_1269055 | chr6_44450044_+ | SINE | Alu | Name=AluSx |
| ADediting_1269056 | chr6_44450064_+ | SINE | Alu | Name=AluSx |
| ADediting_1269057 | chr6_44450073_+ | SINE | Alu | Name=AluSx |
| ADediting_1269058 | chr6_44450085_+ | SINE | Alu | Name=AluSx |
| ADediting_1269059 | chr6_44450098_+ | SINE | Alu | Name=AluSx |
| ADediting_1269060 | chr6_44450125_+ | SINE | Alu | Name=AluSx |
| ADediting_1269061 | chr6_44450126_+ | SINE | Alu | Name=AluSx |
| ADediting_1269062 | chr6_44450138_+ | SINE | Alu | Name=AluSx |
| ADediting_1584123 | chr6_44429227_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1584124 | chr6_44449408_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1584125 | chr6_44450103_+ | SINE | Alu | Name=AluSx |
| ADediting_1584126 | chr6_44450135_+ | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for CDC5L |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CDC5L |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CDC5L |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for CDC5L |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1269041 | chr6_44449399_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-513a-5p | chr6 | 44449393 | 44449399 | 7mer-m8 | 44449383 | 44449400 | 148 | -15.33 |
| ADediting_1269042 | chr6_44449400_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3117-3p | chr6 | 44449398 | 44449404 | 7mer-m8 | 44449385 | 44449405 | 144 | -13.58 |
| ADediting_1269042 | chr6_44449400_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3169 | chr6 | 44449398 | 44449404 | 7mer-1a | 44449381 | 44449404 | 143 | -19.85 |
| ADediting_1269042 | chr6_44449400_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4759 | chr6 | 44449397 | 44449404 | 8mer-1a | 44449384 | 44449404 | 151 | -14.96 |
| ADediting_1269043 | chr6_44449405_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-5006-5p | chr6 | 44449401 | 44449407 | 7mer-m8 | 44449388 | 44449408 | 150 | -22.56 |
| ADediting_1269045 | chr6_44449422_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3176 | chr6 | 44449415 | 44449421 | 7mer-m8 | 44449404 | 44449422 | 140 | -15.24 |
| ADediting_1269045 | chr6_44449422_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3620-3p | chr6 | 44449419 | 44449425 | 7mer-m8 | 44449404 | 44449426 | 156 | -24.24 |
| ADediting_1269045 | chr6_44449422_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3922-3p | chr6 | 44449415 | 44449421 | 7mer-m8 | 44449401 | 44449422 | 141 | -17.02 |
| ADediting_1269048 | chr6_44449448_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-125a-5p | chr6 | 44449441 | 44449447 | 7mer-m8 | 44449424 | 44449448 | 143 | -20.37 |
| ADediting_1269048 | chr6_44449448_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-125b-5p | chr6 | 44449441 | 44449447 | 7mer-m8 | 44449428 | 44449448 | 145 | -17.5 |
| ADediting_1269048 | chr6_44449448_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4319 | chr6 | 44449441 | 44449447 | 7mer-m8 | 44449430 | 44449448 | 147 | -18.38 |
| ADediting_1269049 | chr6_44449459_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-1972 | chr6 | 44449457 | 44449463 | 7mer-m8 | 44449443 | 44449464 | 143 | -22.29 |
| ADediting_1269051 | chr6_44449923_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-324-3p | chr6 | 44449917 | 44449923 | 7mer-m8 | 44449902 | 44449924 | 148 | -24.11 |
| ADediting_1269053 | chr6_44449990_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-619-3p | chr6 | 44449985 | 44449992 | 8mer-1a | 44449970 | 44449992 | 149 | -16.72 |
| ADediting_1269053 | chr6_44449990_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-7851-3p | chr6 | 44449986 | 44449992 | 7mer-1a | 44449971 | 44449992 | 164 | -32.02 |
| ADediting_1269054 | chr6_44450003_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-17-3p | chr6 | 44449999 | 44450005 | 7mer-m8 | 44449984 | 44450006 | 158 | -20.42 |
| ADediting_1269056 | chr6_44450064_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3120-3p | chr6 | 44450058 | 44450064 | 7mer-m8 | 44450045 | 44450065 | 141 | -15.07 |
| ADediting_1269056 | chr6_44450064_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-545-3p | chr6 | 44450057 | 44450063 | 7mer-m8 | 44450043 | 44450064 | 148 | -13.31 |
| ADediting_1269057 | chr6_44450073_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3940-3p | chr6 | 44450070 | 44450076 | 7mer-m8 | 44450059 | 44450077 | 144 | -24.53 |
| ADediting_1269060 | chr6_44450125_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-326 | chr6 | 44450120 | 44450126 | 7mer-m8 | 44450108 | 44450127 | 140 | -13.37 |
| ADediting_1269060 | chr6_44450125_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-330-5p | chr6 | 44450120 | 44450126 | 7mer-m8 | 44450106 | 44450127 | 140 | -21.58 |
| ADediting_1269060 | chr6_44450125_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4314 | chr6 | 44450119 | 44450125 | 7mer-m8 | 44450109 | 44450126 | 140 | -21.18 |
| ADediting_1269060 | chr6_44450125_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-514a-5p | chr6 | 44450121 | 44450127 | 7mer-m8 | 44450105 | 44450128 | 146 | -18.62 |
| ADediting_1269061 | chr6_44450126_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3189-3p | chr6 | 44450120 | 44450126 | 7mer-m8 | 44450108 | 44450127 | 149 | -26.33 |
| ADediting_1269061 | chr6_44450126_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-6813-3p | chr6 | 44450121 | 44450127 | 7mer-m8 | 44450108 | 44450128 | 140 | -11.13 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-518a-3p | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449391 | 44449412 | 145 | -17.85 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-518b | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449392 | 44449412 | 146 | -21.82 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-518c-3p | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449391 | 44449412 | 146 | -18.78 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-518d-3p | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449392 | 44449412 | 145 | -18.54 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-518e-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449390 | 44449411 | 144 | -15.13 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-518f-3p | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449392 | 44449412 | 145 | -18.18 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-526a-3p | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449392 | 44449412 | 146 | -18.41 |
| ADediting_1584125 | chr6_44450103_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4776-5p | chr6 | 44450100 | 44450106 | 7mer-m8 | 44450084 | 44450107 | 147 | -24.94 |
| ADediting_1584125 | chr6_44450103_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4800-5p | chr6 | 44450101 | 44450107 | 7mer-m8 | 44450083 | 44450108 | 152 | -24.76 |
| ADediting_1584126 | chr6_44450135_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-1251-5p | chr6 | 44450128 | 44450134 | 7mer-m8 | 44450115 | 44450135 | 140 | -17.69 |
| ADediting_1584126 | chr6_44450135_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-5684 | chr6 | 44450129 | 44450135 | 7mer-m8 | 44450116 | 44450136 | 146 | -16.36 |
| ADediting_1584126 | chr6_44450135_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-618 | chr6 | 44450130 | 44450137 | 8mer-1a | 44450119 | 44450137 | 142 | -7.52 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1269041 | chr6_44449399_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-6504-3p | chr6 | 44449394 | 44449400 | 7mer-m8 | 44449380 | 44449401 | 144 | -10.34 |
| ADediting_1269041 | chr6_44449399_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-7151-3p | chr6 | 44449392 | 44449399 | 8mer-1a | 44449379 | 44449399 | 146 | -17.44 |
| ADediting_1269042 | chr6_44449400_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-6504-3p | chr6 | 44449394 | 44449400 | 7mer-m8 | 44449380 | 44449401 | 144 | -10.34 |
| ADediting_1269044 | chr6_44449421_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-6878-3p | chr6 | 44449414 | 44449421 | 8mer-1a | 44449401 | 44449421 | 142 | -17.1 |
| ADediting_1269046 | chr6_44449440_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-372-5p | chr6 | 44449434 | 44449440 | 7mer-m8 | 44449419 | 44449441 | 145 | -13.41 |
| ADediting_1269047 | chr6_44449445_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-1200 | chr6 | 44449441 | 44449447 | 7mer-m8 | 44449427 | 44449448 | 153 | -28.33 |
| ADediting_1269048 | chr6_44449448_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-1200 | chr6 | 44449441 | 44449447 | 7mer-m8 | 44449427 | 44449448 | 153 | -28.33 |
| ADediting_1269048 | chr6_44449448_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4680-5p | chr6 | 44449446 | 44449452 | 7mer-1a | 44449432 | 44449452 | 153 | -23.3 |
| ADediting_1269052 | chr6_44449981_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3929 | chr6 | 44449978 | 44449984 | 7mer-m8 | 44449962 | 44449985 | 151 | -21.16 |
| ADediting_1269052 | chr6_44449981_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4478 | chr6 | 44449978 | 44449984 | 7mer-m8 | 44449968 | 44449985 | 154 | -22.07 |
| ADediting_1269052 | chr6_44449981_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-4649-3p | chr6 | 44449975 | 44449981 | 7mer-m8 | 44449962 | 44449982 | 140 | -14.19 |
| ADediting_1269052 | chr6_44449981_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-7160-5p | chr6 | 44449976 | 44449982 | 7mer-m8 | 44449963 | 44449983 | 144 | -16.34 |
| ADediting_1269053 | chr6_44449990_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-890 | chr6 | 44449985 | 44449992 | 8mer-1a | 44449974 | 44449992 | 154 | -18.35 |
| ADediting_1269057 | chr6_44450073_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3190-5p | chr6 | 44450067 | 44450073 | 7mer-m8 | 44450054 | 44450074 | 147 | -20.96 |
| ADediting_1269057 | chr6_44450073_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-548s | chr6 | 44450066 | 44450072 | 7mer-m8 | 44450051 | 44450073 | 152 | -16.7 |
| ADediting_1269059 | chr6_44450098_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3622a-3p | chr6 | 44450095 | 44450102 | 8mer-1a | 44450081 | 44450102 | 144 | -13.55 |
| ADediting_1269059 | chr6_44450098_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-3622b-3p | chr6 | 44450095 | 44450102 | 8mer-1a | 44450082 | 44450102 | 152 | -18.25 |
| ADediting_1269059 | chr6_44450098_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-7162-3p | chr6 | 44450092 | 44450098 | 7mer-m8 | 44450079 | 44450099 | 147 | -18.73 |
| ADediting_1269060 | chr6_44450125_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-887-5p | chr6 | 44450118 | 44450125 | 8mer-1a | 44450104 | 44450125 | 152 | -15.73 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-302a-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449390 | 44449411 | 143 | -11.23 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-302b-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449389 | 44449411 | 141 | -10.24 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-302c-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449391 | 44449411 | 145 | -12.61 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-302d-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449384 | 44449411 | 144 | -10.74 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-302e | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449395 | 44449411 | 141 | -8.91 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-372-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449391 | 44449411 | 149 | -14.6 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-519d-3p | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449392 | 44449412 | 146 | -14.53 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-520a-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449390 | 44449411 | 140 | -11.73 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-520b-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449392 | 44449411 | 141 | -17.22 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-520c-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449391 | 44449411 | 146 | -17.22 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-520d-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449390 | 44449411 | 140 | -13.79 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-520e-3p | chr6 | 44449404 | 44449410 | 7mer-m8 | 44449391 | 44449411 | 140 | -14.02 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-520g-3p | chr6 | 44449406 | 44449412 | 7mer-m8 | 44449391 | 44449413 | 151 | -16.57 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-520h | chr6 | 44449406 | 44449412 | 7mer-m8 | 44449392 | 44449413 | 150 | -15.78 |
| ADediting_1584124 | chr6_44449408_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-526b-3p | chr6 | 44449405 | 44449411 | 7mer-m8 | 44449392 | 44449412 | 146 | -17.36 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-151a-3p | chr6 | 44448451 | 44448458 | 8mer-1a | 44448439 | 44448458 | 150 | -19.46 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-381-3p | chr6 | 44447223 | 44447229 | 7mer-1a | 44447208 | 44447229 | 144 | -17.47 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-337-3p | chr6 | 44447630 | 44447637 | 8mer-1a | 44447618 | 44447637 | 144 | -11.38 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000096401.8 | ENST00000371477.4 | CDC5L-201 | hsa-miR-556-3p | chr6 | 44448518 | 44448524 | 7mer-m8 | 44448505 | 44448525 | 146 | -10.47 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CDC5L |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000371477.4 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1269041 | ENST00000371477.4 | chr6_44449399_+ | 5215 | -1698.60 | -1698.50 | -1698.60 |
| ADediting_1269042 | ENST00000371477.4 | chr6_44449400_+ | 5216 | -1698.50 | -1698.50 | -1698.60 |
| ADediting_1269043 | ENST00000371477.4 | chr6_44449405_+ | 5221 | -1698.20 | -1698.50 | -1698.60 |
| ADediting_1584124 | ENST00000371477.4 | chr6_44449408_+ | 5224 | -1698.10 | -1698.50 | -1698.60 |
| ADediting_1269044 | ENST00000371477.4 | chr6_44449421_+ | 5237 | -1704.50 | -1698.50 | -1698.60 |
| ADediting_1269045 | ENST00000371477.4 | chr6_44449422_+ | 5238 | -1698.40 | -1698.50 | -1698.60 |
| ADediting_1269046 | ENST00000371477.4 | chr6_44449440_+ | 5256 | -1697.60 | -1698.50 | -1698.60 |
| ADediting_1269047 | ENST00000371477.4 | chr6_44449445_+ | 5261 | -1697.80 | -1698.50 | -1698.60 |
| ADediting_1269048 | ENST00000371477.4 | chr6_44449448_+ | 5264 | -1697.50 | -1698.50 | -1698.60 |
| ADediting_1269049 | ENST00000371477.4 | chr6_44449459_+ | 5275 | -1697.20 | -1698.50 | -1698.60 |
| ADediting_1269050 | ENST00000371477.4 | chr6_44449469_+ | 5285 | -1698.50 | -1698.50 | -1698.60 |
| ADediting_1269051 | ENST00000371477.4 | chr6_44449923_+ | 5739 | -1705.10 | -1698.50 | -1698.60 |
| ADediting_1269052 | ENST00000371477.4 | chr6_44449981_+ | 5797 | -1697.80 | -1698.50 | -1698.60 |
| ADediting_1269053 | ENST00000371477.4 | chr6_44449990_+ | 5806 | -1698.50 | -1698.50 | -1698.60 |
| ADediting_1269054 | ENST00000371477.4 | chr6_44450003_+ | 5819 | -1699.60 | -1698.50 | -1698.60 |
| ADediting_1269055 | ENST00000371477.4 | chr6_44450044_+ | 5860 | -1698.10 | -1698.50 | -1698.60 |
| ADediting_1269056 | ENST00000371477.4 | chr6_44450064_+ | 5880 | -1698.50 | -1698.50 | -1698.60 |
| ADediting_1269057 | ENST00000371477.4 | chr6_44450073_+ | 5889 | -1697.80 | -1698.50 | -1698.60 |
| ADediting_1269058 | ENST00000371477.4 | chr6_44450085_+ | 5901 | -1698.00 | -1698.50 | -1698.60 |
| ADediting_1269059 | ENST00000371477.4 | chr6_44450098_+ | 5914 | -1697.70 | -1698.50 | -1698.60 |
| ADediting_1584125 | ENST00000371477.4 | chr6_44450103_+ | 5919 | -1697.90 | -1698.50 | -1698.60 |
| ADediting_1269060 | ENST00000371477.4 | chr6_44450125_+ | 5941 | -1698.60 | -1698.50 | -1698.60 |
| ADediting_1269061 | ENST00000371477.4 | chr6_44450126_+ | 5942 | -1698.20 | -1698.50 | -1698.60 |
| ADediting_1584126 | ENST00000371477.4 | chr6_44450135_+ | 5951 | -1698.80 | -1698.50 | -1698.60 |
| ADediting_1269062 | ENST00000371477.4 | chr6_44450138_+ | 5954 | -1698.50 | -1698.50 | -1698.60 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CDC5L |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1269044 | chr6_44449421_+ | 1.52277717500995e-06 | 0.380875540334126 | 3.22730169366415e-11 | 0.508011729944102 | 0.582478044252339 | 0.0452439140633561 |
| TCX | ADediting_1269044 | chr6_44449421_+ | 0.00477244373834192 | 0.229256508520564 | 7.80038972321781e-07 | 0.390506916880082 | 0.115339040767467 | -0.129110348119866 |
| DLPFC | ADediting_1269056 | chr6_44450064_+ | 6.01635243930512e-11 | 0.360520711610307 | 5.10117796687489e-10 | 0.343622977915178 | 0.00461824808129815 | 0.160480729013089 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.18186498928625e-73 | 0.810062801755808 | 2.00047648726181e-64 | 0.779102554384403 | 0.20001389970363 | 0.0729827223103681 |
| AC | 2.878704058128e-86 | 0.889368016569053 | 6.46004638522624e-49 | 0.763072790229604 | 1.84628369764507e-19 | 0.529391178979466 |
| PCC | 7.39929045987169e-51 | 0.834722579296995 | 5.61168029209723e-52 | 0.839588021872705 | 0.0145565922680422 | 0.17655362177968 |
| CER | 2.27519942424671e-43 | 0.851661724955333 | 1.29233177438016e-29 | 0.76107598003544 | 0.00081303540482856 | 0.270535846221356 |
| TCX | 8.63423881702909e-53 | 0.89162311929086 | 5.06846227778454e-15 | 0.582856142703739 | 0.00215039034058912 | 0.248685057275465 |
| FP | 3.02501629253363e-21 | 0.632092564407232 | 2.85419058428281e-24 | 0.667015029963121 | 0.950282237557299 | 0.00470664022330249 |
| IFG | 4.97200168304085e-05 | 0.719898971889924 | 0.00792942143834205 | 0.518443567554855 | 0.953266953259157 | -0.0123529628567995 |
| PG | 4.72535180411179e-60 | 0.875612880243692 | 2.8113755165192e-26 | 0.676904360308317 | 0.979265995607762 | -0.00191854845379177 |
| STG | 4.88628836620517e-20 | 0.801962157890382 | 6.13116690599078e-17 | 0.758856827248928 | 0.626656713624621 | -0.0538429768615029 |
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Relation with AD stages for CDC5L |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| IFG | ADediting_1269059 | chr6_44450098_+ | 0.0113059937049014 | 0.497952103823781 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.45464587870282e-05 | 0.387325964530744 |
| TCX | 0.000436730133561714 | 0.335601595920474 |
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RelatedDrugs for CDC5L |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC5L |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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