|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for LZTS3 |
 Gene summary |
| Gene information | Gene symbol | LZTS3 | Gene ID | 9762 |
| Gene name | leucine zipper tumor suppressor family member 3 | |
| Synonyms | PROSAPIP1 | |
| Cytomap | 20p13 | |
| Type of gene | protein-coding | |
| Description | leucine zipper putative tumor suppressor 3ProSAP/Shank-interacting protein 1leucine zipper, putative tumor suppressor family member 3proline rich synapse associated protein interacting protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | O60299, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for LZTS3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_918329(3167473, -), ADediting_918405(3169133, -), ADediting_918406(3169204, -), ADediting_918407(3169228, -), ADediting_918414(3169634, -), ADediting_918415(3169635, -), ADediting_918416(3169649, -), ADediting_918417(3169657, -), ADediting_918418(3169658, -), ADediting_918420(3169661, -), ADediting_918421(3169696, -), ADediting_918423(3169770, -), ADediting_918424(3169778, -), ADediting_918430(3170394, -), ADediting_918444(3171543, -), ADediting_918446(3171565, -), ADediting_918447(3171572, -), ADediting_918448(3171582, -), ADediting_918450(3171596, -), ADediting_918451(3171603, -), ADediting_918452(3171608, -), ADediting_918453(3171661, -), |
Top |
RNA editing positional annotations for LZTS3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_918329 | chr20_3167473_- | UTR5 |
| ADediting_918405 | chr20_3169133_- | intronic |
| ADediting_918406 | chr20_3169204_- | intronic |
| ADediting_918407 | chr20_3169228_- | intronic |
| ADediting_918414 | chr20_3169634_- | intronic |
| ADediting_918415 | chr20_3169635_- | intronic |
| ADediting_918416 | chr20_3169649_- | intronic |
| ADediting_918417 | chr20_3169657_- | intronic |
| ADediting_918418 | chr20_3169658_- | intronic |
| ADediting_918420 | chr20_3169661_- | intronic |
| ADediting_918421 | chr20_3169696_- | intronic |
| ADediting_918423 | chr20_3169770_- | intronic |
| ADediting_918424 | chr20_3169778_- | intronic |
| ADediting_918430 | chr20_3170394_- | intronic |
| ADediting_918444 | chr20_3171543_- | intronic |
| ADediting_918446 | chr20_3171565_- | intronic |
| ADediting_918447 | chr20_3171572_- | intronic |
| ADediting_918448 | chr20_3171582_- | intronic |
| ADediting_918450 | chr20_3171596_- | intronic |
| ADediting_918451 | chr20_3171603_- | intronic |
| ADediting_918452 | chr20_3171608_- | intronic |
| ADediting_918453 | chr20_3171661_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_918405 | chr20_3169133_- | DNA | hAT-Tip100 | Name=MER96 |
| ADediting_918406 | chr20_3169204_- | DNA | hAT-Tip100 | Name=MER96 |
| ADediting_918407 | chr20_3169228_- | DNA | hAT-Tip100 | Name=MER96 |
| ADediting_918414 | chr20_3169634_- | SINE | Alu | Name=AluSz6 |
| ADediting_918415 | chr20_3169635_- | SINE | Alu | Name=AluSz6 |
| ADediting_918416 | chr20_3169649_- | SINE | Alu | Name=AluSz6 |
| ADediting_918417 | chr20_3169657_- | SINE | Alu | Name=AluSz6 |
| ADediting_918418 | chr20_3169658_- | SINE | Alu | Name=AluSz6 |
| ADediting_918420 | chr20_3169661_- | SINE | Alu | Name=AluSz6 |
| ADediting_918421 | chr20_3169696_- | SINE | Alu | Name=AluSz6 |
| ADediting_918423 | chr20_3169770_- | SINE | Alu | Name=AluSz6 |
| ADediting_918424 | chr20_3169778_- | SINE | Alu | Name=AluSz6 |
| ADediting_918430 | chr20_3170394_- | SINE | Alu | Name=AluSz |
| ADediting_918444 | chr20_3171543_- | SINE | Alu | Name=AluSx |
| ADediting_918446 | chr20_3171565_- | SINE | Alu | Name=AluSx |
| ADediting_918447 | chr20_3171572_- | SINE | Alu | Name=AluSx |
| ADediting_918448 | chr20_3171582_- | SINE | Alu | Name=AluSx |
| ADediting_918450 | chr20_3171596_- | SINE | Alu | Name=AluSx |
| ADediting_918451 | chr20_3171603_- | SINE | Alu | Name=AluSx |
| ADediting_918452 | chr20_3171608_- | SINE | Alu | Name=AluSx |
| ADediting_918453 | chr20_3171661_- | SINE | Alu | Name=AluSx |
Top |
RNA A-to-I editing events in the alternative splicing sites for LZTS3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for LZTS3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
 | |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for LZTS3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for LZTS3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000329152.7 | LZTS3-201 | hsa-miR-641 | chr20 | 3164419 | 3164425 | 7mer-m8 | 3164418 | 3164441 | 154 | -15.82 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000337576.6 | LZTS3-202 | hsa-miR-641 | chr20 | 3164419 | 3164425 | 7mer-m8 | 3164418 | 3164441 | 154 | -15.82 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000360342.7 | LZTS3-203 | hsa-miR-641 | chr20 | 3164419 | 3164425 | 7mer-m8 | 3164418 | 3164441 | 154 | -15.82 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000645462.1 | LZTS3-204 | hsa-miR-641 | chr20 | 3164419 | 3164425 | 7mer-m8 | 3164418 | 3164441 | 154 | -15.82 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000088899.15 | ENST00000329152.7 | LZTS3-201 | hsa-miR-5585-3p | chr20 | 3162852 | 3162858 | 7mer-m8 | 3162851 | 3162873 | 148 | -17.94 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000088899.15 | ENST00000337576.6 | LZTS3-202 | hsa-miR-5585-3p | chr20 | 3162852 | 3162858 | 7mer-m8 | 3162851 | 3162873 | 148 | -17.94 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000088899.15 | ENST00000360342.7 | LZTS3-203 | hsa-miR-5585-3p | chr20 | 3162852 | 3162858 | 7mer-m8 | 3162851 | 3162873 | 148 | -17.94 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000088899.15 | ENST00000645462.1 | LZTS3-204 | hsa-miR-5585-3p | chr20 | 3162852 | 3162858 | 7mer-m8 | 3162851 | 3162873 | 148 | -17.94 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1556067 | chr19_40282625_- | ENSG00000088899.15 | ENST00000329152.7 | LZTS3-201 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000088899.15 | ENST00000337576.6 | LZTS3-202 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000088899.15 | ENST00000360342.7 | LZTS3-203 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000088899.15 | ENST00000645462.1 | LZTS3-204 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000329152.7 | LZTS3-201 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000337576.6 | LZTS3-202 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000360342.7 | LZTS3-203 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000088899.15 | ENST00000645462.1 | LZTS3-204 | hsa-miR-641 | chr20 | 3163548 | 3163554 | 7mer-m8 | 3163547 | 3163570 | 155 | -16.23 |
| ADediting_496066 | chr15_66496985_- | ENSG00000088899.15 | ENST00000329152.7 | LZTS3-201 | hsa-miR-4512 | chr20 | 3163378 | 3163384 | 7mer-m8 | 3163377 | 3163397 | 146 | -18.39 |
| ADediting_496066 | chr15_66496985_- | ENSG00000088899.15 | ENST00000337576.6 | LZTS3-202 | hsa-miR-4512 | chr20 | 3163378 | 3163384 | 7mer-m8 | 3163377 | 3163397 | 146 | -18.39 |
| ADediting_496066 | chr15_66496985_- | ENSG00000088899.15 | ENST00000360342.7 | LZTS3-203 | hsa-miR-4512 | chr20 | 3163378 | 3163384 | 7mer-m8 | 3163377 | 3163397 | 146 | -18.39 |
| ADediting_496066 | chr15_66496985_- | ENSG00000088899.15 | ENST00000645462.1 | LZTS3-204 | hsa-miR-4512 | chr20 | 3163378 | 3163384 | 7mer-m8 | 3163377 | 3163397 | 146 | -18.39 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for LZTS3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000329152.7 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_918329 | ENST00000329152.7 | chr20_3167473_- | 1089 | -2429.90 | -2424.00 | -2429.90 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for LZTS3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_918405 | chr20_3169133_- | 6.38253049447934e-10 | 0.341791778313554 | 1.33516128571947e-15 | 0.433043194206948 | 0.394029952272177 | 0.0485768477224662 |
| TCX | ADediting_918405 | chr20_3169133_- | 1.57451056910311e-06 | 0.380386394665377 | 1.06434692966166e-06 | 0.386070521694802 | 0.0196332488904805 | -0.190358823737201 |
| DLPFC | ADediting_918407 | chr20_3169228_- | 1.29410649523133e-05 | 0.244901018053923 | 1.5899561438254e-08 | 0.314096314619125 | 0.894437754768346 | -0.00756680299180997 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.96971359554941e-60 | 0.760973969890729 | 6.80633260775901e-61 | 0.765334926244699 | 2.51735672010974e-17 | 0.456016707863993 |
| AC | 2.85266989174165e-59 | 0.809437419436792 | 5.37476423004744e-89 | 0.895149758086237 | 0.0209215311677844 | 0.14600726146566 |
| PCC | 9.2018317495224e-64 | 0.882298383194364 | 7.61373603113267e-96 | 0.947912684779007 | 0.020284632217707 | 0.167853127962859 |
| CER | 1.32672037602838e-28 | 0.752230884726937 | 1.42777395728483e-35 | 0.806322992067433 | 0.0395872739054151 | 0.168245102799172 |
| TCX | 1.18139108535327e-24 | 0.713735865328491 | 3.13119644394576e-62 | 0.920385598527129 | 0.00244809160450728 | -0.245626358437175 |
| FP | 6.2458013877343e-27 | 0.694261129738655 | 1.85946947405537e-17 | 0.581017353578779 | 0.000457907886104151 | 0.259955307702564 |
| IFG | 2.53484671596328e-06 | 0.790844054488283 | 8.06089673910924e-09 | 0.878053872955036 | 0.527472213603709 | 0.132602636672511 |
| PG | 0.000679953525227468 | 0.24691544748866 | 2.65892676211407e-08 | 0.393908564254012 | 0.295224067669196 | -0.0771556332249292 |
| STG | 1.32736415863186e-28 | 0.882564758584647 | 5.91388661032837e-17 | 0.759100515231298 | 0.345535509540467 | 0.104201565016325 |
Top |
Relation with AD stages for LZTS3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000766374750850776 | 0.318975694272665 |
Top |
RelatedDrugs for LZTS3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for LZTS3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|