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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for KMT2B |
 Gene summary |
| Gene information | Gene symbol | KMT2B | Gene ID | 9757 |
| Gene name | lysine methyltransferase 2B | |
| Synonyms | CXXC10|DYT28|HRX2|MLL1B|MLL2|MLL4|TRX2|WBP-7|WBP7 | |
| Cytomap | 19q13.12 | |
| Type of gene | protein-coding | |
| Description | histone-lysine N-methyltransferase 2BWW domain binding protein 7histone-lysine N-methyltransferase MLL4lysine (K)-specific methyltransferase 2Bmixed lineage leukemia gene homolog 2myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosoph | |
| Modification date | 20200313 | |
| UniProtAcc | Q9UMN6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KMT2B | GO:0044648 | histone H3-K4 dimethylation | 25561738 |
| KMT2B | GO:0097692 | histone H3-K4 monomethylation | 25561738 |
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RNA A-to-I events for KMT2B |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_740796(35720497, +), |
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RNA editing positional annotations for KMT2B using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_740796 | chr19_35720497_+ | nonsynonymous SNV | ENST00000420124.2 | c.A1150G | p.R384G | 0.17 | 0.004 | -1.38 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_740796 | chr19_35720497_+ | exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for KMT2B |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KMT2B |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for KMT2B |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for KMT2B |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for KMT2B |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000420124.2 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_740796 | ENST00000420124.2 | chr19_35720497_+ | 1150 | -3714.24 | -3707.64 | -3714.24 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for KMT2B |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 5.84966620004109e-16 | 0.437962606259518 | 2.96596338188113e-28 | 0.571308551754267 | 9.72019164642724e-13 | 0.390577082165846 |
| AC | 2.73161265181677e-32 | 0.657163712904706 | 9.06383935434749e-26 | 0.599331388618034 | 2.3231915566638e-24 | 0.585096870374114 |
| PCC | 1.05870100955009e-11 | 0.46629007960486 | 4.70916558425859e-12 | 0.473275537515735 | 1.16135320559643e-07 | 0.37204412682927 |
| CER | 0.135054024016954 | 0.122587377683787 | 1.77757886939697e-06 | 0.378603599175998 | 0.0036631467434949 | 0.235873697108871 |
| TCX | 8.54615771868794e-05 | 0.315186044249556 | 0.00233700952348944 | 0.246726073120775 | 1.61623801598236e-08 | 0.441040745407649 |
| FP | 5.58279183420282e-07 | 0.364715635963316 | 0.699125047805608 | 0.029168873627664 | 7.72547101726249e-13 | 0.50364746598709 |
| IFG | 4.90812679463467e-05 | 0.720262161942639 | 0.00021106365237195 | 0.675510838562341 | 0.00155666549626988 | 0.599006995631624 |
| PG | 0.63357757221072 | -0.03517948652782 | 0.926652076275535 | -0.00679574345114334 | 3.69314600068076e-09 | 0.415507385667422 |
| STG | 0.0178521796202258 | 0.257918736795735 | 0.563731137779913 | -0.0638823223735965 | 1.09405151018112e-05 | 0.459583718823308 |
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Relation with AD stages for KMT2B |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.00126556235556311 | 0.306272363946911 |
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RelatedDrugs for KMT2B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KMT2B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| KMT2B | C3714756 | Intellectual Disability | 6 | GENOMICS_ENGLAND |
| KMT2B | C4310633 | DYSTONIA 28, CHILDHOOD-ONSET | 2 | UNIPROT |
| KMT2B | C0013421 | Dystonia | 1 | CTD_human |
| KMT2B | C0393588 | Dystonia, Paroxysmal | 1 | CTD_human |
| KMT2B | C0393610 | Dystonia, Diurnal | 1 | CTD_human |
| KMT2B | C0751093 | Dystonia, Limb | 1 | CTD_human |
| KMT2B | C2239176 | Liver carcinoma | 1 | CTD_human |
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