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	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene

Gene summary for PREPL

Gene summary

Gene information	Gene symbol	PREPL
	Gene ID	9581
	Gene name	prolyl endopeptidase like
	Synonyms	CMS22
	Cytomap	2p21
	Type of gene	protein-coding
	Description	prolyl endopeptidase-likeputative prolyl oligopeptidase
	Modification date	20200313
	UniProtAcc	Q4J6C6,
	Context	- 23485813(Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for PREPL

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_877451(44324621, -), ADediting_877452(44324634, -), ADediting_877453(44324673, -), ADediting_877454(44324675, -), ADediting_877455(44324681, -), ADediting_877456(44324690, -), ADediting_877457(44324698, -), ADediting_877458(44324850, -), ADediting_877459(44326475, -), ADediting_877460(44326476, -), ADediting_877461(44326541, -), ADediting_877462(44326542, -), ADediting_877463(44326551, -), ADediting_877464(44326590, -), ADediting_877465(44326602, -), ADediting_877466(44326607, -), ADediting_877467(44326608, -), ADediting_877468(44345360, -), ADediting_877469(44345574, -), ADediting_877470(44345612, -), ADediting_877471(44345620, -), ADediting_877472(44345621, -), ADediting_877473(44345629, -), ADediting_877474(44345897, -), ADediting_877475(44345924, -), ADediting_877476(44345925, -), ADediting_877477(44345970, -), ADediting_877478(44347074, -), ADediting_877479(44347113, -), ADediting_877480(44347114, -), ADediting_877481(44347195, -), ADediting_877482(44347213, -), ADediting_877483(44347223, -), ADediting_877484(44347227, -), ADediting_877485(44347235, -), ADediting_877486(44347240, -), ADediting_877487(44347274, -), ADediting_877488(44347279, -), ADediting_877489(44347297, -), ADediting_877490(44348132, -), ADediting_877491(44351008, -), ADediting_877492(44351015, -), ADediting_877493(44351019, -), ADediting_877494(44351034, -), ADediting_877495(44351143, -), ADediting_877496(44352291, -), ADediting_877497(44352292, -), ADediting_877498(44352326, -), ADediting_877499(44352339, -), ADediting_877500(44352356, -), ADediting_877501(44352361, -), ADediting_877502(44352382, -), ADediting_877503(44352404, -), ADediting_877504(44352426, -), ADediting_877505(44352455, -), ADediting_877506(44352456, -), ADediting_877507(44352457, -), ADediting_877508(44352458, -), ADediting_877509(44352465, -), ADediting_877510(44352477, -), ADediting_877511(44352480, -), ADediting_877512(44352481, -), ADediting_877513(44352486, -), ADediting_877514(44352487, -), ADediting_877515(44352489, -), ADediting_877516(44352546, -), ADediting_877517(44352547, -), ADediting_877518(44352553, -), ADediting_877519(44352558, -), ADediting_877520(44353327, -), ADediting_877521(44353368, -), ADediting_877522(44353405, -), ADediting_877523(44353512, -), ADediting_877524(44353525, -), ADediting_877525(44353536, -), ADediting_877526(44353904, -), ADediting_877527(44353926, -), ADediting_877528(44353943, -), ADediting_877529(44353944, -), ADediting_877530(44353949, -), ADediting_877531(44353950, -), ADediting_877532(44353957, -), ADediting_877533(44353958, -), ADediting_877534(44353981, -), ADediting_877535(44354045, -), ADediting_877536(44354048, -), ADediting_877537(44354087, -), ADediting_877538(44354094, -), ADediting_877539(44354142, -), ADediting_877540(44354150, -), ADediting_877541(44354152, -), ADediting_877542(44354602, -), ADediting_877543(44354632, -), ADediting_877544(44354642, -), ADediting_877545(44354651, -), ADediting_877546(44354656, -), ADediting_877547(44354671, -), ADediting_877548(44354672, -), ADediting_877549(44354677, -), ADediting_877550(44354680, -), ADediting_877551(44354681, -), ADediting_877552(44354686, -), ADediting_877553(44354703, -), ADediting_877554(44354712, -), ADediting_877555(44354713, -), ADediting_877556(44354739, -), ADediting_877557(44354745, -), ADediting_877558(44354747, -), ADediting_877559(44354752, -), ADediting_877560(44354755, -), ADediting_877561(44354765, -), ADediting_877562(44354773, -), ADediting_877563(44354780, -), ADediting_877564(44354795, -), ADediting_877565(44354796, -), ADediting_877566(44354804, -), ADediting_877567(44354841, -), ADediting_877568(44354849, -), ADediting_877569(44354850, -), ADediting_877570(44354852, -), ADediting_877571(44354858, -), ADediting_877572(44355282, -), ADediting_877573(44355285, -), ADediting_877574(44355289, -), ADediting_877575(44355303, -), ADediting_877576(44355304, -), ADediting_877577(44355326, -), ADediting_877578(44355330, -), ADediting_877579(44355331, -), ADediting_877580(44355337, -), ADediting_877581(44355355, -), ADediting_877582(44355364, -), ADediting_877583(44355375, -), ADediting_877584(44355379, -), ADediting_877585(44355381, -), ADediting_877586(44355384, -), ADediting_877587(44355385, -), ADediting_877588(44355390, -), ADediting_877589(44355392, -), ADediting_877590(44355405, -), ADediting_877591(44355409, -), ADediting_877592(44355421, -), ADediting_877593(44355425, -), ADediting_877594(44355427, -), ADediting_877595(44355436, -), ADediting_877596(44355437, -), ADediting_877597(44355449, -), ADediting_877598(44355466, -), ADediting_877599(44355467, -), ADediting_877600(44355473, -), ADediting_877601(44355480, -), ADediting_877602(44355486, -), ADediting_877603(44355487, -), ADediting_877604(44355492, -), ADediting_877605(44355503, -), ADediting_877606(44355505, -), ADediting_877607(44355527, -), ADediting_877608(44355535, -), ADediting_877609(44355543, -), ADediting_877610(44355547, -), ADediting_877611(44356285, -), ADediting_877612(44356297, -), ADediting_877613(44356316, -), ADediting_877614(44356325, -), ADediting_877615(44356350, -), ADediting_877616(44356362, -), ADediting_877617(44356370, -), ADediting_877618(44356376, -), ADediting_877619(44356379, -), ADediting_877620(44356424, -), ADediting_877621(44356434, -), ADediting_877622(44356437, -), ADediting_877623(44356469, -), ADediting_877624(44356476, -), ADediting_877625(44356482, -), ADediting_877626(44356541, -), ADediting_877627(44356543, -), ADediting_877628(44356902, -), ADediting_877629(44356937, -), ADediting_877630(44356942, -), ADediting_877631(44356943, -), ADediting_877632(44356961, -), ADediting_877633(44356969, -), ADediting_877634(44356972, -), ADediting_877635(44356981, -), ADediting_877636(44356984, -), ADediting_877637(44356985, -), ADediting_877638(44356994, -), ADediting_877639(44357001, -), ADediting_877640(44357002, -), ADediting_877641(44357007, -), ADediting_877642(44357009, -), ADediting_877643(44357022, -), ADediting_877644(44357029, -), ADediting_877645(44357033, -), ADediting_877646(44357038, -), ADediting_877647(44357048, -), ADediting_877648(44357056, -), ADediting_877649(44357057, -), ADediting_877650(44357070, -), ADediting_877651(44357073, -), ADediting_877652(44357078, -), ADediting_877653(44357079, -), ADediting_877654(44357082, -), ADediting_877655(44357087, -), ADediting_877656(44359161, -), ADediting_877657(44359165, -), ADediting_877658(44359189, -), ADediting_877659(44359205, -), ADediting_877660(44359206, -), ADediting_877661(44359228, -), ADediting_877662(44359241, -), ADediting_877663(44359243, -), ADediting_877664(44359263, -), ADediting_1563548(44347167, -), ADediting_1563549(44347226, -), ADediting_1563550(44352475, -), ADediting_1563551(44353956, -), ADediting_1563552(44354049, -), ADediting_1563553(44355516, -), ADediting_1563554(44356853, -), ADediting_1563555(44356982, -), ADediting_1563556(44357019, -), ADediting_1637681(44347086, -), ADediting_1637682(44351060, -), ADediting_1637683(44351071, -), ADediting_1637684(44356927, -), ADediting_1637685(44356973, -),

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RNA editing positional annotations for PREPL using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_877451	chr2_44324621_-	intronic
ADediting_877452	chr2_44324634_-	intronic
ADediting_877453	chr2_44324673_-	intronic
ADediting_877454	chr2_44324675_-	intronic
ADediting_877455	chr2_44324681_-	intronic
ADediting_877456	chr2_44324690_-	intronic
ADediting_877457	chr2_44324698_-	intronic
ADediting_877458	chr2_44324850_-	intronic
ADediting_877459	chr2_44326475_-	intronic
ADediting_877460	chr2_44326476_-	intronic
ADediting_877461	chr2_44326541_-	intronic
ADediting_877462	chr2_44326542_-	intronic
ADediting_877463	chr2_44326551_-	intronic
ADediting_877464	chr2_44326590_-	intronic
ADediting_877465	chr2_44326602_-	intronic
ADediting_877466	chr2_44326607_-	intronic
ADediting_877467	chr2_44326608_-	intronic
ADediting_877468	chr2_44345360_-	intronic
ADediting_877469	chr2_44345574_-	intronic
ADediting_877470	chr2_44345612_-	intronic
ADediting_877471	chr2_44345620_-	intronic
ADediting_877472	chr2_44345621_-	intronic
ADediting_877473	chr2_44345629_-	intronic
ADediting_877474	chr2_44345897_-	intronic
ADediting_877475	chr2_44345924_-	intronic
ADediting_877476	chr2_44345925_-	intronic
ADediting_877477	chr2_44345970_-	intronic
ADediting_877478	chr2_44347074_-	intronic
ADediting_877479	chr2_44347113_-	intronic
ADediting_877480	chr2_44347114_-	intronic
ADediting_877481	chr2_44347195_-	intronic
ADediting_877482	chr2_44347213_-	intronic
ADediting_877483	chr2_44347223_-	intronic
ADediting_877484	chr2_44347227_-	intronic
ADediting_877485	chr2_44347235_-	intronic
ADediting_877486	chr2_44347240_-	intronic
ADediting_877487	chr2_44347274_-	intronic
ADediting_877488	chr2_44347279_-	intronic
ADediting_877489	chr2_44347297_-	intronic
ADediting_877490	chr2_44348132_-	intronic
ADediting_877491	chr2_44351008_-	intronic
ADediting_877492	chr2_44351015_-	intronic
ADediting_877493	chr2_44351019_-	intronic
ADediting_877494	chr2_44351034_-	intronic
ADediting_877495	chr2_44351143_-	intronic
ADediting_877496	chr2_44352291_-	intronic
ADediting_877497	chr2_44352292_-	intronic
ADediting_877498	chr2_44352326_-	intronic
ADediting_877499	chr2_44352339_-	intronic
ADediting_877500	chr2_44352356_-	intronic
ADediting_877501	chr2_44352361_-	intronic
ADediting_877502	chr2_44352382_-	intronic
ADediting_877503	chr2_44352404_-	intronic
ADediting_877504	chr2_44352426_-	intronic
ADediting_877505	chr2_44352455_-	intronic
ADediting_877506	chr2_44352456_-	intronic
ADediting_877507	chr2_44352457_-	intronic
ADediting_877508	chr2_44352458_-	intronic
ADediting_877509	chr2_44352465_-	intronic
ADediting_877510	chr2_44352477_-	intronic
ADediting_877511	chr2_44352480_-	intronic
ADediting_877512	chr2_44352481_-	intronic
ADediting_877513	chr2_44352486_-	intronic
ADediting_877514	chr2_44352487_-	intronic
ADediting_877515	chr2_44352489_-	intronic
ADediting_877516	chr2_44352546_-	intronic
ADediting_877517	chr2_44352547_-	intronic
ADediting_877518	chr2_44352553_-	intronic
ADediting_877519	chr2_44352558_-	intronic
ADediting_877520	chr2_44353327_-	intronic
ADediting_877521	chr2_44353368_-	intronic
ADediting_877522	chr2_44353405_-	intronic
ADediting_877523	chr2_44353512_-	intronic
ADediting_877524	chr2_44353525_-	intronic
ADediting_877525	chr2_44353536_-	intronic
ADediting_877526	chr2_44353904_-	intronic
ADediting_877527	chr2_44353926_-	intronic
ADediting_877528	chr2_44353943_-	intronic
ADediting_877529	chr2_44353944_-	intronic
ADediting_877530	chr2_44353949_-	intronic
ADediting_877531	chr2_44353950_-	intronic
ADediting_877532	chr2_44353957_-	intronic
ADediting_877533	chr2_44353958_-	intronic
ADediting_877534	chr2_44353981_-	intronic
ADediting_877535	chr2_44354045_-	intronic
ADediting_877536	chr2_44354048_-	intronic
ADediting_877537	chr2_44354087_-	intronic
ADediting_877538	chr2_44354094_-	intronic
ADediting_877539	chr2_44354142_-	intronic
ADediting_877540	chr2_44354150_-	intronic
ADediting_877541	chr2_44354152_-	intronic
ADediting_877542	chr2_44354602_-	intronic
ADediting_877543	chr2_44354632_-	intronic
ADediting_877544	chr2_44354642_-	intronic
ADediting_877545	chr2_44354651_-	intronic
ADediting_877546	chr2_44354656_-	intronic
ADediting_877547	chr2_44354671_-	intronic
ADediting_877548	chr2_44354672_-	intronic
ADediting_877549	chr2_44354677_-	intronic
ADediting_877550	chr2_44354680_-	intronic
ADediting_877551	chr2_44354681_-	intronic
ADediting_877552	chr2_44354686_-	intronic
ADediting_877553	chr2_44354703_-	intronic
ADediting_877554	chr2_44354712_-	intronic
ADediting_877555	chr2_44354713_-	intronic
ADediting_877556	chr2_44354739_-	intronic
ADediting_877557	chr2_44354745_-	intronic
ADediting_877558	chr2_44354747_-	intronic
ADediting_877559	chr2_44354752_-	intronic
ADediting_877560	chr2_44354755_-	intronic
ADediting_877561	chr2_44354765_-	intronic
ADediting_877562	chr2_44354773_-	intronic
ADediting_877563	chr2_44354780_-	intronic
ADediting_877564	chr2_44354795_-	intronic
ADediting_877565	chr2_44354796_-	intronic
ADediting_877566	chr2_44354804_-	intronic
ADediting_877567	chr2_44354841_-	intronic
ADediting_877568	chr2_44354849_-	intronic
ADediting_877569	chr2_44354850_-	intronic
ADediting_877570	chr2_44354852_-	intronic
ADediting_877571	chr2_44354858_-	intronic
ADediting_877572	chr2_44355282_-	intronic
ADediting_877573	chr2_44355285_-	intronic
ADediting_877574	chr2_44355289_-	intronic
ADediting_877575	chr2_44355303_-	intronic
ADediting_877576	chr2_44355304_-	intronic
ADediting_877577	chr2_44355326_-	intronic
ADediting_877578	chr2_44355330_-	intronic
ADediting_877579	chr2_44355331_-	intronic
ADediting_877580	chr2_44355337_-	intronic
ADediting_877581	chr2_44355355_-	intronic
ADediting_877582	chr2_44355364_-	intronic
ADediting_877583	chr2_44355375_-	intronic
ADediting_877584	chr2_44355379_-	intronic
ADediting_877585	chr2_44355381_-	intronic
ADediting_877586	chr2_44355384_-	intronic
ADediting_877587	chr2_44355385_-	intronic
ADediting_877588	chr2_44355390_-	intronic
ADediting_877589	chr2_44355392_-	intronic
ADediting_877590	chr2_44355405_-	intronic
ADediting_877591	chr2_44355409_-	intronic
ADediting_877592	chr2_44355421_-	intronic
ADediting_877593	chr2_44355425_-	intronic
ADediting_877594	chr2_44355427_-	intronic
ADediting_877595	chr2_44355436_-	intronic
ADediting_877596	chr2_44355437_-	intronic
ADediting_877597	chr2_44355449_-	intronic
ADediting_877598	chr2_44355466_-	intronic
ADediting_877599	chr2_44355467_-	intronic
ADediting_877600	chr2_44355473_-	intronic
ADediting_877601	chr2_44355480_-	intronic
ADediting_877602	chr2_44355486_-	intronic
ADediting_877603	chr2_44355487_-	intronic
ADediting_877604	chr2_44355492_-	intronic
ADediting_877605	chr2_44355503_-	intronic
ADediting_877606	chr2_44355505_-	intronic
ADediting_877607	chr2_44355527_-	intronic
ADediting_877608	chr2_44355535_-	intronic
ADediting_877609	chr2_44355543_-	intronic
ADediting_877610	chr2_44355547_-	intronic
ADediting_877611	chr2_44356285_-	intronic
ADediting_877612	chr2_44356297_-	intronic
ADediting_877613	chr2_44356316_-	intronic
ADediting_877614	chr2_44356325_-	intronic
ADediting_877615	chr2_44356350_-	intronic
ADediting_877616	chr2_44356362_-	intronic
ADediting_877617	chr2_44356370_-	intronic
ADediting_877618	chr2_44356376_-	intronic
ADediting_877619	chr2_44356379_-	intronic
ADediting_877620	chr2_44356424_-	intronic
ADediting_877621	chr2_44356434_-	intronic
ADediting_877622	chr2_44356437_-	intronic
ADediting_877623	chr2_44356469_-	intronic
ADediting_877624	chr2_44356476_-	intronic
ADediting_877625	chr2_44356482_-	intronic
ADediting_877626	chr2_44356541_-	intronic
ADediting_877627	chr2_44356543_-	intronic
ADediting_877628	chr2_44356902_-	intronic
ADediting_877629	chr2_44356937_-	intronic
ADediting_877630	chr2_44356942_-	intronic
ADediting_877631	chr2_44356943_-	intronic
ADediting_877632	chr2_44356961_-	intronic
ADediting_877633	chr2_44356969_-	intronic
ADediting_877634	chr2_44356972_-	intronic
ADediting_877635	chr2_44356981_-	intronic
ADediting_877636	chr2_44356984_-	intronic
ADediting_877637	chr2_44356985_-	intronic
ADediting_877638	chr2_44356994_-	intronic
ADediting_877639	chr2_44357001_-	intronic
ADediting_877640	chr2_44357002_-	intronic
ADediting_877641	chr2_44357007_-	intronic
ADediting_877642	chr2_44357009_-	intronic
ADediting_877643	chr2_44357022_-	intronic
ADediting_877644	chr2_44357029_-	intronic
ADediting_877645	chr2_44357033_-	intronic
ADediting_877646	chr2_44357038_-	intronic
ADediting_877647	chr2_44357048_-	intronic
ADediting_877648	chr2_44357056_-	intronic
ADediting_877649	chr2_44357057_-	intronic
ADediting_877650	chr2_44357070_-	intronic
ADediting_877651	chr2_44357073_-	intronic
ADediting_877652	chr2_44357078_-	intronic
ADediting_877653	chr2_44357079_-	intronic
ADediting_877654	chr2_44357082_-	intronic
ADediting_877655	chr2_44357087_-	intronic
ADediting_877656	chr2_44359161_-	intronic
ADediting_877657	chr2_44359165_-	intronic
ADediting_877658	chr2_44359189_-	intronic
ADediting_877659	chr2_44359205_-	intronic
ADediting_877660	chr2_44359206_-	intronic
ADediting_877661	chr2_44359228_-	intronic
ADediting_877662	chr2_44359241_-	intronic
ADediting_877663	chr2_44359243_-	intronic
ADediting_877664	chr2_44359263_-	intronic
ADediting_1563548	chr2_44347167_-	intronic
ADediting_1563549	chr2_44347226_-	intronic
ADediting_1563550	chr2_44352475_-	intronic
ADediting_1563551	chr2_44353956_-	intronic
ADediting_1563552	chr2_44354049_-	intronic
ADediting_1563553	chr2_44355516_-	intronic
ADediting_1563554	chr2_44356853_-	intronic
ADediting_1563555	chr2_44356982_-	intronic
ADediting_1563556	chr2_44357019_-	intronic
ADediting_1637681	chr2_44347086_-	intronic
ADediting_1637682	chr2_44351060_-	intronic
ADediting_1637683	chr2_44351071_-	intronic
ADediting_1637684	chr2_44356927_-	intronic
ADediting_1637685	chr2_44356973_-	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_877451	chr2_44324621_-	SINE	Alu	Name=AluJb
ADediting_877452	chr2_44324634_-	SINE	Alu	Name=AluJb
ADediting_877453	chr2_44324673_-	SINE	Alu	Name=AluJb
ADediting_877454	chr2_44324675_-	SINE	Alu	Name=AluJb
ADediting_877455	chr2_44324681_-	SINE	Alu	Name=AluJb
ADediting_877456	chr2_44324690_-	SINE	Alu	Name=AluJb
ADediting_877457	chr2_44324698_-	SINE	Alu	Name=AluJb
ADediting_877458	chr2_44324850_-	SINE	Alu	Name=AluJb
ADediting_877459	chr2_44326475_-	SINE	Alu	Name=AluJo
ADediting_877460	chr2_44326476_-	SINE	Alu	Name=AluJo
ADediting_877461	chr2_44326541_-	SINE	Alu	Name=AluJo
ADediting_877462	chr2_44326542_-	SINE	Alu	Name=AluJo
ADediting_877463	chr2_44326551_-	SINE	Alu	Name=AluJo
ADediting_877464	chr2_44326590_-	SINE	Alu	Name=AluJo
ADediting_877465	chr2_44326602_-	SINE	Alu	Name=AluJo
ADediting_877466	chr2_44326607_-	SINE	Alu	Name=AluJo
ADediting_877467	chr2_44326608_-	SINE	Alu	Name=AluJo
ADediting_877468	chr2_44345360_-	SINE	Alu	Name=AluSx1
ADediting_877469	chr2_44345574_-	SINE	Alu	Name=AluSx1
ADediting_877470	chr2_44345612_-	SINE	Alu	Name=AluSx1
ADediting_877471	chr2_44345620_-	SINE	Alu	Name=AluSx1
ADediting_877472	chr2_44345621_-	SINE	Alu	Name=AluSx1
ADediting_877473	chr2_44345629_-	SINE	Alu	Name=AluSx1
ADediting_877474	chr2_44345897_-	SINE	Alu	Name=AluJo
ADediting_877475	chr2_44345924_-	SINE	Alu	Name=AluJo
ADediting_877476	chr2_44345925_-	SINE	Alu	Name=AluJo
ADediting_877477	chr2_44345970_-	SINE	Alu	Name=AluJo
ADediting_877478	chr2_44347074_-	SINE	Alu	Name=AluJo
ADediting_877479	chr2_44347113_-	SINE	Alu	Name=AluJo
ADediting_877480	chr2_44347114_-	SINE	Alu	Name=AluJo
ADediting_877481	chr2_44347195_-	SINE	Alu	Name=AluJo
ADediting_877482	chr2_44347213_-	SINE	Alu	Name=AluJo
ADediting_877483	chr2_44347223_-	SINE	Alu	Name=AluJo
ADediting_877484	chr2_44347227_-	SINE	Alu	Name=AluJo
ADediting_877485	chr2_44347235_-	SINE	Alu	Name=AluJo
ADediting_877486	chr2_44347240_-	SINE	Alu	Name=AluJo
ADediting_877487	chr2_44347274_-	SINE	Alu	Name=AluJo
ADediting_877488	chr2_44347279_-	SINE	Alu	Name=AluJo
ADediting_877489	chr2_44347297_-	SINE	Alu	Name=AluJo
ADediting_877490	chr2_44348132_-	SINE	Alu	Name=FLAM_C
ADediting_877491	chr2_44351008_-	SINE	Alu	Name=AluSq10
ADediting_877492	chr2_44351015_-	SINE	Alu	Name=AluSq10
ADediting_877493	chr2_44351019_-	SINE	Alu	Name=AluSq10
ADediting_877494	chr2_44351034_-	SINE	Alu	Name=AluSq10
ADediting_877495	chr2_44351143_-	SINE	Alu	Name=AluSq10
ADediting_877496	chr2_44352291_-	SINE	Alu	Name=AluSz6
ADediting_877497	chr2_44352292_-	SINE	Alu	Name=AluSz6
ADediting_877498	chr2_44352326_-	SINE	Alu	Name=AluSz6
ADediting_877499	chr2_44352339_-	SINE	Alu	Name=AluSz6
ADediting_877500	chr2_44352356_-	SINE	Alu	Name=AluSz6
ADediting_877501	chr2_44352361_-	SINE	Alu	Name=AluSz6
ADediting_877502	chr2_44352382_-	SINE	Alu	Name=AluSz6
ADediting_877503	chr2_44352404_-	SINE	Alu	Name=AluSz6
ADediting_877504	chr2_44352426_-	SINE	Alu	Name=AluSz6
ADediting_877505	chr2_44352455_-	SINE	Alu	Name=AluSz6
ADediting_877506	chr2_44352456_-	SINE	Alu	Name=AluSz6
ADediting_877507	chr2_44352457_-	SINE	Alu	Name=AluSz6
ADediting_877508	chr2_44352458_-	SINE	Alu	Name=AluSz6
ADediting_877509	chr2_44352465_-	SINE	Alu	Name=AluSz6
ADediting_877510	chr2_44352477_-	SINE	Alu	Name=AluSz6
ADediting_877511	chr2_44352480_-	SINE	Alu	Name=AluSz6
ADediting_877512	chr2_44352481_-	SINE	Alu	Name=AluSz6
ADediting_877513	chr2_44352486_-	SINE	Alu	Name=AluSz6
ADediting_877514	chr2_44352487_-	SINE	Alu	Name=AluSz6
ADediting_877515	chr2_44352489_-	SINE	Alu	Name=AluSz6
ADediting_877516	chr2_44352546_-	SINE	Alu	Name=AluSz6
ADediting_877517	chr2_44352547_-	SINE	Alu	Name=AluSz6
ADediting_877518	chr2_44352553_-	SINE	Alu	Name=AluSz6
ADediting_877519	chr2_44352558_-	LINE	L2	Name=L2a
ADediting_877520	chr2_44353327_-	SINE	Alu	Name=AluSx1
ADediting_877521	chr2_44353368_-	SINE	Alu	Name=AluSx1
ADediting_877522	chr2_44353405_-	SINE	Alu	Name=AluSx1
ADediting_877523	chr2_44353512_-	SINE	Alu	Name=AluSx1
ADediting_877524	chr2_44353525_-	SINE	Alu	Name=AluSx1
ADediting_877525	chr2_44353536_-	SINE	Alu	Name=AluSx1
ADediting_877526	chr2_44353904_-	SINE	Alu	Name=AluJb
ADediting_877527	chr2_44353926_-	SINE	Alu	Name=AluJb
ADediting_877528	chr2_44353943_-	SINE	Alu	Name=AluJb
ADediting_877529	chr2_44353944_-	SINE	Alu	Name=AluJb
ADediting_877530	chr2_44353949_-	SINE	Alu	Name=AluJb
ADediting_877531	chr2_44353950_-	SINE	Alu	Name=AluJb
ADediting_877532	chr2_44353957_-	SINE	Alu	Name=AluJb
ADediting_877533	chr2_44353958_-	SINE	Alu	Name=AluJb
ADediting_877534	chr2_44353981_-	SINE	Alu	Name=AluJb
ADediting_877535	chr2_44354045_-	SINE	Alu	Name=AluJb
ADediting_877536	chr2_44354048_-	SINE	Alu	Name=AluJb
ADediting_877537	chr2_44354087_-	SINE	Alu	Name=AluJb
ADediting_877538	chr2_44354094_-	SINE	Alu	Name=AluJb
ADediting_877539	chr2_44354142_-	SINE	Alu	Name=AluJb
ADediting_877540	chr2_44354150_-	SINE	Alu	Name=AluJb
ADediting_877541	chr2_44354152_-	SINE	Alu	Name=AluJb
ADediting_877542	chr2_44354602_-	SINE	Alu	Name=AluSx
ADediting_877543	chr2_44354632_-	SINE	Alu	Name=AluSx
ADediting_877544	chr2_44354642_-	SINE	Alu	Name=AluSx
ADediting_877545	chr2_44354651_-	SINE	Alu	Name=AluSx
ADediting_877546	chr2_44354656_-	SINE	Alu	Name=AluSx
ADediting_877547	chr2_44354671_-	SINE	Alu	Name=AluSx
ADediting_877548	chr2_44354672_-	SINE	Alu	Name=AluSx
ADediting_877549	chr2_44354677_-	SINE	Alu	Name=AluSx
ADediting_877550	chr2_44354680_-	SINE	Alu	Name=AluSx
ADediting_877551	chr2_44354681_-	SINE	Alu	Name=AluSx
ADediting_877552	chr2_44354686_-	SINE	Alu	Name=AluSx
ADediting_877553	chr2_44354703_-	SINE	Alu	Name=AluSx
ADediting_877554	chr2_44354712_-	SINE	Alu	Name=AluSx
ADediting_877555	chr2_44354713_-	SINE	Alu	Name=AluSx
ADediting_877556	chr2_44354739_-	SINE	Alu	Name=AluSx
ADediting_877557	chr2_44354745_-	SINE	Alu	Name=AluSx
ADediting_877558	chr2_44354747_-	SINE	Alu	Name=AluSx
ADediting_877559	chr2_44354752_-	SINE	Alu	Name=AluSx
ADediting_877560	chr2_44354755_-	SINE	Alu	Name=AluSx
ADediting_877561	chr2_44354765_-	SINE	Alu	Name=AluSx
ADediting_877562	chr2_44354773_-	SINE	Alu	Name=AluSx
ADediting_877563	chr2_44354780_-	SINE	Alu	Name=AluSx
ADediting_877564	chr2_44354795_-	SINE	Alu	Name=AluSx
ADediting_877565	chr2_44354796_-	SINE	Alu	Name=AluSx
ADediting_877566	chr2_44354804_-	SINE	Alu	Name=AluSx
ADediting_877567	chr2_44354841_-	SINE	Alu	Name=AluSx
ADediting_877568	chr2_44354849_-	SINE	Alu	Name=AluSx
ADediting_877569	chr2_44354850_-	SINE	Alu	Name=AluSx
ADediting_877570	chr2_44354852_-	SINE	Alu	Name=AluSx
ADediting_877571	chr2_44354858_-	SINE	Alu	Name=AluSx
ADediting_877572	chr2_44355282_-	SINE	Alu	Name=AluSz6
ADediting_877573	chr2_44355285_-	SINE	Alu	Name=AluSz6
ADediting_877574	chr2_44355289_-	SINE	Alu	Name=AluSz6
ADediting_877575	chr2_44355303_-	SINE	Alu	Name=AluSz6
ADediting_877576	chr2_44355304_-	SINE	Alu	Name=AluSz6
ADediting_877577	chr2_44355326_-	SINE	Alu	Name=AluSz6
ADediting_877578	chr2_44355330_-	SINE	Alu	Name=AluSz6
ADediting_877579	chr2_44355331_-	SINE	Alu	Name=AluSz6
ADediting_877580	chr2_44355337_-	SINE	Alu	Name=AluSz6
ADediting_877581	chr2_44355355_-	SINE	Alu	Name=AluSz6
ADediting_877582	chr2_44355364_-	SINE	Alu	Name=AluSz6
ADediting_877583	chr2_44355375_-	SINE	Alu	Name=AluSz6
ADediting_877584	chr2_44355379_-	SINE	Alu	Name=AluSz6
ADediting_877585	chr2_44355381_-	SINE	Alu	Name=AluSz6
ADediting_877586	chr2_44355384_-	SINE	Alu	Name=AluSz6
ADediting_877587	chr2_44355385_-	SINE	Alu	Name=AluSz6
ADediting_877588	chr2_44355390_-	SINE	Alu	Name=AluSz6
ADediting_877589	chr2_44355392_-	SINE	Alu	Name=AluSz6
ADediting_877590	chr2_44355405_-	SINE	Alu	Name=AluSz6
ADediting_877591	chr2_44355409_-	SINE	Alu	Name=AluSz6
ADediting_877592	chr2_44355421_-	SINE	Alu	Name=AluSz6
ADediting_877593	chr2_44355425_-	SINE	Alu	Name=AluSz6
ADediting_877594	chr2_44355427_-	SINE	Alu	Name=AluSz6
ADediting_877595	chr2_44355436_-	SINE	Alu	Name=AluSz6
ADediting_877596	chr2_44355437_-	SINE	Alu	Name=AluSz6
ADediting_877597	chr2_44355449_-	SINE	Alu	Name=AluSz6
ADediting_877598	chr2_44355466_-	SINE	Alu	Name=AluSz6
ADediting_877599	chr2_44355467_-	SINE	Alu	Name=AluSz6
ADediting_877600	chr2_44355473_-	SINE	Alu	Name=AluSz6
ADediting_877601	chr2_44355480_-	SINE	Alu	Name=AluSz6
ADediting_877602	chr2_44355486_-	SINE	Alu	Name=AluSz6
ADediting_877603	chr2_44355487_-	SINE	Alu	Name=AluSz6
ADediting_877604	chr2_44355492_-	SINE	Alu	Name=AluSz6
ADediting_877605	chr2_44355503_-	SINE	Alu	Name=AluSz6
ADediting_877606	chr2_44355505_-	SINE	Alu	Name=AluSz6
ADediting_877607	chr2_44355527_-	SINE	Alu	Name=AluSz6
ADediting_877608	chr2_44355535_-	SINE	Alu	Name=AluSz6
ADediting_877609	chr2_44355543_-	SINE	Alu	Name=AluSz6
ADediting_877610	chr2_44355547_-	SINE	Alu	Name=AluSz6
ADediting_877611	chr2_44356285_-	SINE	Alu	Name=AluSx1
ADediting_877612	chr2_44356297_-	SINE	Alu	Name=AluSx1
ADediting_877613	chr2_44356316_-	SINE	Alu	Name=AluSx1
ADediting_877614	chr2_44356325_-	SINE	Alu	Name=AluSx1
ADediting_877615	chr2_44356350_-	SINE	Alu	Name=AluSx1
ADediting_877616	chr2_44356362_-	SINE	Alu	Name=AluSx1
ADediting_877617	chr2_44356370_-	SINE	Alu	Name=AluSx1
ADediting_877618	chr2_44356376_-	SINE	Alu	Name=AluSx1
ADediting_877619	chr2_44356379_-	SINE	Alu	Name=AluSx1
ADediting_877620	chr2_44356424_-	SINE	Alu	Name=AluSx1
ADediting_877621	chr2_44356434_-	SINE	Alu	Name=AluSx1
ADediting_877622	chr2_44356437_-	SINE	Alu	Name=AluSx1
ADediting_877623	chr2_44356469_-	SINE	Alu	Name=AluSx1
ADediting_877624	chr2_44356476_-	SINE	Alu	Name=AluSx1
ADediting_877625	chr2_44356482_-	SINE	Alu	Name=AluSx1
ADediting_877626	chr2_44356541_-	SINE	Alu	Name=AluSx1
ADediting_877627	chr2_44356543_-	SINE	Alu	Name=AluSx1
ADediting_877628	chr2_44356902_-	SINE	Alu	Name=AluJb
ADediting_877629	chr2_44356937_-	SINE	Alu	Name=AluJb
ADediting_877630	chr2_44356942_-	SINE	Alu	Name=AluJb
ADediting_877631	chr2_44356943_-	SINE	Alu	Name=AluJb
ADediting_877632	chr2_44356961_-	SINE	Alu	Name=AluJb
ADediting_877633	chr2_44356969_-	SINE	Alu	Name=AluJb
ADediting_877634	chr2_44356972_-	SINE	Alu	Name=AluJb
ADediting_877635	chr2_44356981_-	SINE	Alu	Name=AluJb
ADediting_877636	chr2_44356984_-	SINE	Alu	Name=AluJb
ADediting_877637	chr2_44356985_-	SINE	Alu	Name=AluJb
ADediting_877638	chr2_44356994_-	SINE	Alu	Name=AluJb
ADediting_877639	chr2_44357001_-	SINE	Alu	Name=AluJb
ADediting_877640	chr2_44357002_-	SINE	Alu	Name=AluJb
ADediting_877641	chr2_44357007_-	SINE	Alu	Name=AluJb
ADediting_877642	chr2_44357009_-	SINE	Alu	Name=AluJb
ADediting_877643	chr2_44357022_-	SINE	Alu	Name=AluJb
ADediting_877644	chr2_44357029_-	SINE	Alu	Name=AluJb
ADediting_877645	chr2_44357033_-	SINE	Alu	Name=AluJb
ADediting_877646	chr2_44357038_-	SINE	Alu	Name=AluJb
ADediting_877647	chr2_44357048_-	SINE	Alu	Name=AluJb
ADediting_877648	chr2_44357056_-	SINE	Alu	Name=AluJb
ADediting_877649	chr2_44357057_-	SINE	Alu	Name=AluJb
ADediting_877650	chr2_44357070_-	SINE	Alu	Name=AluJb
ADediting_877651	chr2_44357073_-	SINE	Alu	Name=AluJb
ADediting_877652	chr2_44357078_-	SINE	Alu	Name=AluJb
ADediting_877653	chr2_44357079_-	SINE	Alu	Name=AluJb
ADediting_877654	chr2_44357082_-	SINE	Alu	Name=AluJb
ADediting_877655	chr2_44357087_-	SINE	Alu	Name=AluJb
ADediting_877656	chr2_44359161_-	SINE	Alu	Name=AluSx
ADediting_877657	chr2_44359165_-	SINE	Alu	Name=AluSx
ADediting_877658	chr2_44359189_-	SINE	Alu	Name=AluSx
ADediting_877659	chr2_44359205_-	SINE	Alu	Name=AluSx
ADediting_877660	chr2_44359206_-	SINE	Alu	Name=AluSx
ADediting_877661	chr2_44359228_-	SINE	Alu	Name=AluSx
ADediting_877662	chr2_44359241_-	SINE	Alu	Name=AluSx
ADediting_877663	chr2_44359243_-	SINE	Alu	Name=AluSx
ADediting_877664	chr2_44359263_-	SINE	Alu	Name=AluSx
ADediting_1563548	chr2_44347167_-	SINE	Alu	Name=AluJo
ADediting_1563549	chr2_44347226_-	SINE	Alu	Name=AluJo
ADediting_1563550	chr2_44352475_-	SINE	Alu	Name=AluSz6
ADediting_1563551	chr2_44353956_-	SINE	Alu	Name=AluJb
ADediting_1563552	chr2_44354049_-	SINE	Alu	Name=AluJb
ADediting_1563553	chr2_44355516_-	SINE	Alu	Name=AluSz6
ADediting_1563554	chr2_44356853_-	SINE	Alu	Name=AluJb
ADediting_1563555	chr2_44356982_-	SINE	Alu	Name=AluJb
ADediting_1563556	chr2_44357019_-	SINE	Alu	Name=AluJb
ADediting_1637681	chr2_44347086_-	SINE	Alu	Name=AluJo
ADediting_1637682	chr2_44351060_-	SINE	Alu	Name=AluSq10
ADediting_1637683	chr2_44351071_-	SINE	Alu	Name=AluSq10
ADediting_1637684	chr2_44356927_-	SINE	Alu	Name=AluJb
ADediting_1637685	chr2_44356973_-	SINE	Alu	Name=AluJb

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RNA A-to-I editing events in the alternative splicing sites for PREPL

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	ADeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ME2	ADediting_877617	chr2_44356370_-	44356366:44356388	3ss	2i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTAGTAGAGACGGGGT	-20.88
ME2	ADediting_877617	chr2_44356370_-	44356366:44356388	3ss	2i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTAGTAGAGACGGGGT	-20.88
ME2	ADediting_877617	chr2_44356370_-	44356366:44356388	3ss	2i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTAGTAGAGACGGGGT	-20.88
ME2	ADediting_877617	chr2_44356370_-	44356366:44356388	3ss	2i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTAGTAGAGACGGGGT	-20.88
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94
ME2	ADediting_877619	chr2_44356379_-	44356366:44356388	3ss	11i	GTATTTTTTAGTAGAGACAGGGT	-12.93	GTATTTTTTGGTAGAGACAGGGT	-6.94

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PREPL

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for PREPL

- Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PREPL

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1563549

chr2_44347226_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-204-3p

chr2

44347226

44347232

7mer-m8

44347225

44347244

150

-19.3

ADediting_877482

chr2_44347213_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-17-3p

chr2

44347210

44347216

7mer-m8

44346390

44347231

158

-20.42

ADediting_877483

chr2_44347223_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-3614-5p

chr2

44347223

44347229

7mer-m8

44347222

44347246

151

-23

ADediting_877483

chr2_44347223_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-4691-3p

chr2

44347219

44347225

7mer-m8

44347218

44347244

156

-30.33

ADediting_877484

chr2_44347227_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-425-3p

chr2

44347226

44347232

7mer-m8

44347225

44347248

146

-15.06

ADediting_877486

chr2_44347240_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-6765-5p

chr2

44347235

44347241

7mer-m8

44347234

44347258

151

-27.27

ADediting_877487

chr2_44347274_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-6089

chr2

44347268

44347275

8mer-1a

44347268

44347291

169

-34.09

ADediting_877489

chr2_44347297_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-324-3p

chr2

44347294

44347300

7mer-m8

44347293

44347318

156

-25.7

ADediting_877489

chr2_44347297_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-4252

chr2

44347292

44347299

8mer-1a

44347292

44347312

154

-23.82

ADediting_877489

chr2_44347297_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-4793-3p

chr2

44347297

44347303

7mer-m8

44347296

44347317

147

-18.07

ADediting_877612

chr2_44356297_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-3189-3p

chr2

44356296

44356302

7mer-m8

44356295

44356318

149

-26.69

ADediting_877612

chr2_44356297_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-6813-3p

chr2

44356295

44356301

7mer-m8

44356294

44356314

140

-12.15

ADediting_877613

chr2_44356316_-

ENSG00000138078.15

ENST00000477410.1

PREPL-214

hsa-miR-3937

chr2

44356312

44356318

7mer-m8

44356311

44356338

144

-24.23

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1563549	chr2_44347226_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-12126	chr2	44347223	44347230	8mer-1a	44347223	44347246	155	-13.95
ADediting_1563549	chr2_44347226_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-450a-1-3p	chr2	44347226	44347232	7mer-m8	44347225	44347246	140	-9.54
ADediting_877483	chr2_44347223_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-5690	chr2	44347219	44347225	7mer-m8	44347218	44347238	145	-16.74
ADediting_877484	chr2_44347227_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-12126	chr2	44347223	44347230	8mer-1a	44347223	44347246	155	-13.95
ADediting_877484	chr2_44347227_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-450a-1-3p	chr2	44347226	44347232	7mer-m8	44347225	44347246	140	-9.54
ADediting_877485	chr2_44347235_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-7160-5p	chr2	44347233	44347239	7mer-m8	44347232	44347252	150	-19.06
ADediting_877485	chr2_44347235_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-7162-3p	chr2	44347234	44347240	7mer-m8	44347233	44347251	152	-18.02
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-1233-5p	chr2	44347239	44347245	7mer-m8	44347238	44347264	151	-26.06
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-1273h-5p	chr2	44347240	44347246	7mer-m8	44347239	44347261	142	-19.43
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-30b-3p	chr2	44347240	44347246	7mer-m8	44347239	44347259	143	-17.13
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-3689a-3p	chr2	44347240	44347246	7mer-m8	44347239	44347260	148	-18.16
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-3689b-3p	chr2	44347240	44347246	7mer-m8	44347239	44347259	150	-17.05
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-3689c	chr2	44347240	44347246	7mer-m8	44347239	44347259	150	-17.05
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-6134	chr2	44347235	44347242	8mer-1a	44347235	44347254	153	-20.31
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-6778-5p	chr2	44347239	44347245	7mer-m8	44347238	44347264	146	-29.74
ADediting_877486	chr2_44347240_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-6779-5p	chr2	44347240	44347246	7mer-m8	44347239	44347263	150	-28.51
ADediting_877487	chr2_44347274_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-6884-5p	chr2	44347268	44347275	8mer-1a	44347268	44347293	155	-21.55
ADediting_877489	chr2_44347297_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-25-3p	chr2	44347296	44347302	7mer-m8	44347295	44347316	146	-19.65
ADediting_877489	chr2_44347297_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-32-5p	chr2	44347296	44347302	7mer-m8	44347295	44347316	152	-14.72
ADediting_877489	chr2_44347297_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-363-3p	chr2	44347296	44347302	7mer-m8	44347295	44347319	147	-13.39
ADediting_877489	chr2_44347297_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-92a-3p	chr2	44347296	44347302	7mer-m8	44347295	44347312	147	-20.69
ADediting_877489	chr2_44347297_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-92b-3p	chr2	44347296	44347302	7mer-m8	44347295	44347316	150	-18.38
ADediting_877613	chr2_44356316_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-12114	chr2	44356313	44356319	7mer-m8	44356312	44356331	148	-25.89
ADediting_877613	chr2_44356316_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-3165	chr2	44356314	44356320	7mer-m8	44356313	44356332	145	-17.82
ADediting_877613	chr2_44356316_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-3665	chr2	44356311	44356317	7mer-m8	44356310	44356327	140	-17.7
ADediting_877614	chr2_44356325_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-3622a-3p	chr2	44356320	44356327	8mer-1a	44356320	44356341	144	-13.8
ADediting_877614	chr2_44356325_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-3622b-3p	chr2	44356320	44356327	8mer-1a	44356320	44356340	149	-17.67
ADediting_877615	chr2_44356350_-	ENSG00000138078.15	ENST00000477410.1	PREPL-214	hsa-miR-4293	chr2	44356346	44356352	7mer-m8	44356345	44356361	145	-19.91

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-5688	chr2	44319121	44319128	8mer-1a	44319121	44319140	152	-14.62
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-5688	chr2	44319121	44319128	8mer-1a	44319121	44319140	152	-14.62
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-5688	chr2	44319121	44319128	8mer-1a	44319121	44319140	152	-14.62
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-5688	chr2	44319121	44319128	8mer-1a	44319121	44319140	152	-14.62
ADediting_1337757	chr7_5495852_-	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-589-3p	chr2	44319963	44319969	7mer-m8	44319962	44319986	141	-14.76
ADediting_1337757	chr7_5495852_-	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-589-3p	chr2	44319963	44319969	7mer-m8	44319962	44319986	141	-14.76
ADediting_1337757	chr7_5495852_-	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-589-3p	chr2	44319963	44319969	7mer-m8	44319962	44319986	141	-14.76
ADediting_1337757	chr7_5495852_-	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-589-3p	chr2	44319963	44319969	7mer-m8	44319962	44319986	141	-14.76
ADediting_1337758	chr7_5495892_-	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-589-5p	chr2	44319181	44319188	8mer-1a	44319181	44319203	150	-23.6
ADediting_1337758	chr7_5495892_-	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-589-5p	chr2	44319181	44319188	8mer-1a	44319181	44319203	150	-23.6
ADediting_1337758	chr7_5495892_-	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-589-5p	chr2	44319181	44319188	8mer-1a	44319181	44319203	150	-23.6
ADediting_1337758	chr7_5495892_-	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-589-5p	chr2	44319181	44319188	8mer-1a	44319181	44319203	150	-23.6
ADediting_1471003	chr9_63819626_+	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-4477b	chr2	44320297	44320304	8mer-1a	44320297	44320317	141	-11.5
ADediting_1471003	chr9_63819626_+	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-4477b	chr2	44320297	44320304	8mer-1a	44320297	44320317	141	-11.5
ADediting_1471003	chr9_63819626_+	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-4477b	chr2	44320297	44320304	8mer-1a	44320297	44320317	141	-11.5
ADediting_1471003	chr9_63819626_+	ENSG00000138078.15	ENST00000444696.5	PREPL-213	hsa-miR-4477b	chr2	44320297	44320304	8mer-1a	44320297	44320317	141	-11.5
ADediting_1471003	chr9_63819626_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-4477b	chr2	44320297	44320304	8mer-1a	44320297	44320317	141	-11.5
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-381-3p	chr2	44319868	44319875	8mer-1a	44319868	44319891	146	-13.08
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-381-3p	chr2	44319868	44319875	8mer-1a	44319868	44319891	146	-13.08
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-381-3p	chr2	44319868	44319875	8mer-1a	44319868	44319891	146	-13.08
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-381-3p	chr2	44319868	44319875	8mer-1a	44319868	44319891	146	-13.08
ADediting_1556067	chr19_40282625_-	ENSG00000138078.15	ENST00000420756.1	PREPL-209	hsa-miR-641	chr2	44321655	44321661	7mer-m8	44321654	44321677	140	-13.41
ADediting_1631458	chr19_40282624_-	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-641	chr2	44317639	44317646	8mer-1a	44317639	44317661	156	-15.79
ADediting_286380	chr11_79422188_-	ENSG00000138078.15	ENST00000260648.10	PREPL-201	hsa-miR-5579-3p	chr2	44320828	44320834	7mer-m8	44320827	44320849	157	-18.55
ADediting_286380	chr11_79422188_-	ENSG00000138078.15	ENST00000409272.5	PREPL-204	hsa-miR-5579-3p	chr2	44320828	44320834	7mer-m8	44320827	44320849	157	-18.55
ADediting_286380	chr11_79422188_-	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-5579-3p	chr2	44320828	44320834	7mer-m8	44320827	44320849	157	-18.55
ADediting_286380	chr11_79422188_-	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-5579-3p	chr2	44320828	44320834	7mer-m8	44320827	44320849	157	-18.55
ADediting_286380	chr11_79422188_-	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-5579-3p	chr2	44320828	44320834	7mer-m8	44320827	44320849	157	-18.55
ADediting_286380	chr11_79422188_-	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-5579-3p	chr2	44320828	44320834	7mer-m8	44320827	44320849	157	-18.55
ADediting_98289	chr1_32086992_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-5585-3p	chr2	44317850	44317856	7mer-m8	44317849	44317870	153	-10

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-5688	chr2	44319784	44319790	7mer-m8	44319783	44319804	142	-11.81
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-5688	chr2	44319784	44319790	7mer-m8	44319783	44319804	142	-11.81
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-5688	chr2	44319784	44319790	7mer-m8	44319783	44319804	142	-11.81
ADediting_1097295	chr3_85385762_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-5688	chr2	44319784	44319790	7mer-m8	44319783	44319804	142	-11.81
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000444696.5	PREPL-213	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535953	chr14_101045971_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535954	chr14_101045974_+	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535954	chr14_101045974_+	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535954	chr14_101045974_+	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535954	chr14_101045974_+	ENSG00000138078.15	ENST00000444696.5	PREPL-213	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_1535954	chr14_101045974_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-381-3p	chr2	44320482	44320488	7mer-m8	44320481	44320502	153	-17.65
ADediting_291761	chr11_93733708_-	ENSG00000138078.15	ENST00000260648.10	PREPL-201	hsa-miR-1304-3p	chr2	44320982	44320988	7mer-m8	44320981	44321005	145	-13.8
ADediting_291761	chr11_93733708_-	ENSG00000138078.15	ENST00000409272.5	PREPL-204	hsa-miR-1304-3p	chr2	44320982	44320988	7mer-m8	44320981	44321005	145	-13.8
ADediting_291761	chr11_93733708_-	ENSG00000138078.15	ENST00000409411.5	PREPL-205	hsa-miR-1304-3p	chr2	44320982	44320988	7mer-m8	44320981	44321005	145	-13.8
ADediting_291761	chr11_93733708_-	ENSG00000138078.15	ENST00000409936.5	PREPL-206	hsa-miR-1304-3p	chr2	44320982	44320988	7mer-m8	44320981	44321005	145	-13.8
ADediting_291761	chr11_93733708_-	ENSG00000138078.15	ENST00000409957.5	PREPL-207	hsa-miR-1304-3p	chr2	44320982	44320988	7mer-m8	44320981	44321005	145	-13.8
ADediting_291761	chr11_93733708_-	ENSG00000138078.15	ENST00000410081.5	PREPL-208	hsa-miR-1304-3p	chr2	44320982	44320988	7mer-m8	44320981	44321005	145	-13.8
ADediting_291761	chr11_93733708_-	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-1304-3p	chr2	44320982	44320988	7mer-m8	44320981	44321005	145	-13.8
ADediting_843620	chr2_207754818_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-4775	chr2	44317621	44317627	7mer-m8	44317620	44317642	143	-3.2
ADediting_843620	chr2_207754818_+	ENSG00000138078.15	ENST00000541738.5	PREPL-216	hsa-miR-4775	chr2	44317652	44317658	7mer-m8	44317651	44317672	141	-2.35

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PREPL

- RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000477410.1	lncRNA

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in lncRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_877482	ENST00000477410.1	chr2_44347213_-	416	-175.60	-175.30	-190.10
ADediting_877483	ENST00000477410.1	chr2_44347223_-	406	-175.30	-175.30	-190.10
ADediting_1563549	ENST00000477410.1	chr2_44347226_-	403	-178.90	-175.30	-190.10
ADediting_877484	ENST00000477410.1	chr2_44347227_-	402	-174.70	-175.30	-190.10
ADediting_877485	ENST00000477410.1	chr2_44347235_-	394	-175.30	-175.30	-190.10
ADediting_877486	ENST00000477410.1	chr2_44347240_-	389	-174.90	-175.30	-190.10
ADediting_877487	ENST00000477410.1	chr2_44347274_-	355	-175.90	-175.30	-190.10
ADediting_877488	ENST00000477410.1	chr2_44347279_-	350	-174.90	-175.30	-190.10
ADediting_877489	ENST00000477410.1	chr2_44347297_-	332	-178.60	-175.30	-190.10
ADediting_877611	ENST00000477410.1	chr2_44356285_-	251	-176.30	-175.30	-190.10
ADediting_877612	ENST00000477410.1	chr2_44356297_-	239	-175.60	-175.30	-190.10
ADediting_877613	ENST00000477410.1	chr2_44356316_-	220	-174.90	-175.30	-190.10
ADediting_877614	ENST00000477410.1	chr2_44356325_-	211	-174.60	-175.30	-190.10
ADediting_877615	ENST00000477410.1	chr2_44356350_-	186	-181.50	-175.30	-190.10
ADediting_877616	ENST00000477410.1	chr2_44356362_-	174	-174.90	-175.30	-190.10

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Relation with ADAR for PREPL

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_877483	chr2_44347223_-	0.000505862025024994	0.280569390237821	4.03500687694657e-06	0.36627076658752	0.0241069934344486	0.18411721021812
CER	ADediting_877484	chr2_44347227_-	0.000297139830823062	0.291391485763494	1.87607802947265e-05	0.341675618886139	0.116850123522738	0.128581069696912
CER	ADediting_877485	chr2_44347235_-	0.000992033698893294	0.266212575399071	4.43513142757524e-05	0.326945958089722	0.123529033764307	0.126303406356487
CER	ADediting_877486	chr2_44347240_-	3.04605798012397e-06	0.37055806792738	9.33775154257987e-09	0.447568218394505	0.325530176267814	0.0808191173437675
CER	ADediting_877487	chr2_44347274_-	0.000175403843329022	0.301706145859588	1.63238260877411e-05	0.343989106519157	0.00813413470698788	0.215342015258156
CER	ADediting_877499	chr2_44352339_-	0.000944320429146584	0.267290171118808	2.26487531111973e-06	0.375011239332557	0.242482047190112	0.0960151103029589
CER	ADediting_877508	chr2_44352458_-	0.000579884208684291	0.277720213013657	3.82140047837255e-05	0.329550187415709	0.187530183013707	0.108196708183854
CER	ADediting_877509	chr2_44352465_-	7.243177739089e-05	0.318198001469152	1.48108327445316e-06	0.381281408858437	0.616200986051755	0.0412538965582654
CER	ADediting_877511	chr2_44352480_-	4.42859283748558e-05	0.32697187098332	1.88576322165763e-06	0.377731494284915	0.313410452373764	0.082861870271102
CER	ADediting_877518	chr2_44352553_-	0.000185156789999652	0.300664849353285	0.000121224515794203	0.308713301715071	0.879923564840427	0.0124380696644447
CER	ADediting_877528	chr2_44353943_-	2.43019232738507e-05	0.33732339036761	0.000618066982185987	0.276379334398536	0.139810941536598	0.121124284573513
CER	ADediting_877530	chr2_44353949_-	1.91725506097164e-05	0.341312975687011	0.00013084702010959	0.30727889667863	0.215909156974968	0.101628110264761
CER	ADediting_877531	chr2_44353950_-	2.84031517183732e-07	0.404497678371921	8.77963644594793e-07	0.388826328836251	0.105252205990267	0.132789305757025
CER	ADediting_877532	chr2_44353957_-	3.81637018409428e-05	0.329573114091753	1.42551857895725e-05	0.34622465282634	0.172193901343368	0.112053150384754
CER	ADediting_877533	chr2_44353958_-	6.4266524251595e-07	0.393239909941054	1.65681389972811e-05	0.343742975916437	0.0293445452865849	0.177966573299451
CER	ADediting_877534	chr2_44353981_-	0.000273639091978754	0.293029504363103	6.97318573103784e-05	0.318885180099986	0.224379415087688	0.0997884460534714
CER	ADediting_877535	chr2_44354045_-	0.00016805885184927	0.302526558055913	2.16346231930601e-05	0.339286694058863	0.0860248101444169	0.140651006512306
CER	ADediting_877545	chr2_44354651_-	0.00305516861972819	0.240312858041622	6.72149954736038e-05	0.319548585226741	0.727135781136649	0.0287250944394626
CER	ADediting_877547	chr2_44354671_-	0.000951805231447515	0.267117873239994	0.000169377029350144	0.302376894964505	0.675213449333774	0.0344898479392213
STG	ADediting_877549	chr2_44354677_-	0.00339281480531058	0.316152309708587	0.0331742598138571	0.232685049004463	0.887991190660429	-0.0156004376090936
CER	ADediting_877552	chr2_44354686_-	0.000679002759121143	0.274389785059635	3.76712033591852e-05	0.329799093208304	0.727594025196969	0.0286748735828319
STG	ADediting_877552	chr2_44354686_-	0.00377560390402512	0.312733458568327	0.00316732210229944	0.318331290180073	0.14749483658104	0.159413496667222
STG	ADediting_877555	chr2_44354713_-	0.0656669873451292	0.201787998743982	0.141024351519255	0.161971326906594	0.00279650719662347	0.32223649730764
STG	ADediting_877556	chr2_44354739_-	0.0567731148326492	0.208690490329252	0.000982181255592277	0.35320557335154	0.692743098646821	0.0437476447523554
STG	ADediting_877562	chr2_44354773_-	0.00238023887723163	0.327217176198767	0.0109683714901162	0.276256618711459	0.650481078925122	-0.0501570149389609
CER	ADediting_877564	chr2_44354795_-	6.05851825482485e-06	0.359961880149725	0.000144942681313602	0.305346053330445	0.524005438317898	0.0524285914421982
CER	ADediting_877570	chr2_44354852_-	3.12257066494911e-05	0.33304426248173	0.000140080782768971	0.305992122867434	0.323078950656588	0.081228246517887
STG	ADediting_877578	chr2_44355330_-	0.0431901375742988	0.221177585445655	0.0040208423456676	0.31070231912365	0.482644105246728	0.0776483190869821
STG	ADediting_877594	chr2_44355427_-	0.000919175516996429	0.355066215385726	0.00213860512011952	0.330480430659311	0.82596474082963	-0.0243521911552398
STG	ADediting_877595	chr2_44355436_-	0.000715095504235244	0.36201238903711	0.00612901045319983	0.296724965360362	0.570986428894835	0.062699662033763
STG	ADediting_877596	chr2_44355437_-	7.24333394679443e-05	0.419127931268391	0.0030667190594232	0.319348531789438	0.540462225775928	0.0677251663868034
DLPFC	ADediting_877601	chr2_44355480_-	0.196751453055201	0.0735137879150164	0.142100589794669	-0.0835692462155803	3.85645829555884e-11	0.363914349604137
STG	ADediting_877602	chr2_44355486_-	0.0136727731179102	0.268107280699099	0.00359105332845601	0.314341091362934	0.836337089181962	-0.0228797148335344
STG	ADediting_877603	chr2_44355487_-	0.00430921885789865	0.30845057128613	0.00790546358958483	0.287951193381118	0.354012199725412	0.102394121328448
STG	ADediting_877604	chr2_44355492_-	0.0319877576088754	0.234235069856006	0.00138147055043488	0.343450111021573	0.65435027874136	-0.0495636258875874
STG	ADediting_877609	chr2_44355543_-	0.000306552013918748	0.384365998207497	0.0761957021896305	0.194533885010868	0.142649834952937	0.16132058471122
STG	ADediting_877612	chr2_44356297_-	0.00145732807204562	0.341892894111047	0.0267474779677021	0.24172196853381	0.715639241456531	0.0403358268684772
DLPFC	ADediting_877623	chr2_44356469_-	0.72551807278258	-0.0200196566528269	0.106343222683478	-0.0918943775309162	9.74066159678423e-10	0.338304461786941
CER	ADediting_877631	chr2_44356943_-	0.000181299653133298	0.301070421089306	0.000759211480848482	0.272007760038234	0.576076034070117	0.046013140915433
CER	ADediting_877647	chr2_44357048_-	2.50694411532456e-05	0.33679604382918	2.81934578509481e-05	0.33479559733991	0.567034351487562	0.0471063819276633
CER	ADediting_877649	chr2_44357057_-	3.07380632015013e-05	0.333314807545854	1.33289720954908e-06	0.382817639741952	0.279132868507429	0.0889356728520826

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	3.90268032744242e-73	0.809260989919234	9.92071366575611e-62	0.768683478052765	0.335963764748056	-0.0548280105625812
AC	3.2475228389029e-91	0.899614462111273	1.3097736876133e-97	0.91139378603071	0.0498656350926335	0.124173647036417
PCC	2.26506720192124e-63	0.881096862580405	3.66092122342532e-78	0.918666258483766	0.684666055033848	0.0295723604421089
CER	1.61928953346401e-36	0.812565598453769	6.65229365886423e-14	0.562723522627015	0.720888411570389	-0.0294108353432421
TCX	6.73389002443541e-33	0.787354738631511	3.70321365246699e-30	0.765670040487646	0.0171663645759431	-0.194348058503915
FP	2.70741439668734e-15	0.547236129387531	2.96528446370737e-22	0.644249942173666	0.0495986645935041	-0.147397360587257
IFG	0.00028556515336001	0.665184384038115	0.00979946945991347	0.506360468072548	0.165015659296531	-0.286485908015426
PG	2.75372630522443e-40	0.786020170726621	6.42951923444702e-30	0.710724862201224	0.0239475898569447	-0.165534355271586
STG	2.67220654283305e-19	0.792557533583288	7.13044151583596e-18	0.772900095507625	0.106795962057742	-0.177226423604558

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Relation with AD stages for PREPL

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
IFG	ADediting_877547	chr2_44354671_-	0.0113059937049014	0.497952103823781
IFG	ADediting_877550	chr2_44354680_-	0.0280743839840878	0.439141444516812
IFG	ADediting_877552	chr2_44354686_-	0.0438875872403181	0.406258872584394
IFG	ADediting_877562	chr2_44354773_-	0.0354713369979928	0.422303326441651
IFG	ADediting_877578	chr2_44355330_-	0.033470010187233	0.426558813802709
IFG	ADediting_877579	chr2_44355331_-	0.0354713369979928	0.422303326441651
IFG	ADediting_877594	chr2_44355427_-	0.0354713369979928	0.422303326441651

Correlation between AD stages and this gene's expression

Tissue

P-val

Coeff.

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RelatedDrugs for PREPL

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PREPL

Diseases associated with this gene. (DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PREPL	C3714756	Intellectual Disability	3	GENOMICS_ENGLAND
PREPL	C0751882	Myasthenic Syndromes, Congenital	2	CTD_human;GENOMICS_ENGLAND
PREPL	C1848030	Hypotonia-Cystinuria Syndrome	1	CTD_human;ORPHANET

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