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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for ATP5MF

check button Gene summary
Gene informationGene symbol

ATP5MF

Gene ID

9551

Gene nameATP synthase membrane subunit f
SynonymsATP5J2|ATP5JL
Cytomap

7q22.1

Type of geneprotein-coding
DescriptionATP synthase subunit f, mitochondrialATP synthase f chain, mitochondrialATP synthase, H+ transporting, mitochondrial F0 complex, subunit fATP synthase, H+ transporting, mitochondrial Fo complex subunit F2F1F0-type ATPase subunit fF1Fo-ATP synthase co
Modification date20200313
UniProtAcc

P56134,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ATP5MF

GO:0042776

mitochondrial ATP synthesis coupled proton transport

12110673


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RNA A-to-I events for ATP5MF

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1376932(99459548, -), ADediting_1376933(99459626, -), ADediting_1376934(99461302, -), ADediting_1376935(99461312, -), ADediting_1376936(99461321, -), ADediting_1376937(99461325, -), ADediting_1376938(99461334, -), ADediting_1376939(99461348, -), ADediting_1376940(99461626, -), ADediting_1376941(99461627, -), ADediting_1376942(99461641, -), ADediting_1376943(99461721, -), ADediting_1376944(99461751, -), ADediting_1376945(99461782, -), ADediting_1376946(99461786, -), ADediting_1376947(99461790, -), ADediting_1376948(99461796, -), ADediting_1376949(99461804, -), ADediting_1376950(99461822, -), ADediting_1376951(99461851, -), ADediting_1376952(99461861, -), ADediting_1376953(99461862, -), ADediting_1376954(99461885, -), ADediting_1376955(99461900, -), ADediting_1376956(99461930, -), ADediting_1376957(99461931, -), ADediting_1376958(99462196, -), ADediting_1376959(99462218, -), ADediting_1376960(99462234, -), ADediting_1376961(99462259, -), ADediting_1376962(99462263, -), ADediting_1376963(99462285, -), ADediting_1376964(99462346, -), ADediting_1376965(99462352, -), ADediting_1376966(99462356, -), ADediting_1376967(99462368, -), ADediting_1376968(99462405, -), ADediting_1376969(99462416, -), ADediting_1376970(99462421, -), ADediting_1376971(99462520, -), ADediting_1376972(99462583, -), ADediting_1376973(99462595, -), ADediting_1376974(99462609, -), ADediting_1376975(99462612, -), ADediting_1376976(99462645, -), ADediting_1376977(99462653, -), ADediting_1376978(99462663, -), ADediting_1376979(99462666, -), ADediting_1376980(99462675, -), ADediting_1376981(99462692, -), ADediting_1376982(99462699, -), ADediting_1376983(99462712, -), ADediting_1376984(99462728, -), ADediting_1376985(99462731, -), ADediting_1376986(99462978, -), ADediting_1376987(99463573, -), ADediting_1376988(99463676, -), ADediting_1376989(99463693, -), ADediting_1376990(99463694, -), ADediting_1376991(99463700, -), ADediting_1376992(99463735, -), ADediting_1376993(99464611, -), ADediting_1376994(99465885, -), ADediting_1589240(99461374, -), ADediting_1589241(99461779, -), ADediting_1589242(99463521, -), ADediting_1589243(99463713, -), ADediting_1589244(99463737, -), ADediting_1589245(99464541, -), ADediting_1667626(99461876, -),

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RNA editing positional annotations for ATP5MF using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1376932chr7_99459548_-intronic
ADediting_1376933chr7_99459626_-intronic
ADediting_1376934chr7_99461302_-intronic
ADediting_1376935chr7_99461312_-intronic
ADediting_1376936chr7_99461321_-intronic
ADediting_1376937chr7_99461325_-intronic
ADediting_1376938chr7_99461334_-intronic
ADediting_1376939chr7_99461348_-intronic
ADediting_1376940chr7_99461626_-intronic
ADediting_1376941chr7_99461627_-intronic
ADediting_1376942chr7_99461641_-intronic
ADediting_1376943chr7_99461721_-intronic
ADediting_1376944chr7_99461751_-intronic
ADediting_1376945chr7_99461782_-intronic
ADediting_1376946chr7_99461786_-intronic
ADediting_1376947chr7_99461790_-intronic
ADediting_1376948chr7_99461796_-intronic
ADediting_1376949chr7_99461804_-intronic
ADediting_1376950chr7_99461822_-intronic
ADediting_1376951chr7_99461851_-intronic
ADediting_1376952chr7_99461861_-intronic
ADediting_1376953chr7_99461862_-intronic
ADediting_1376954chr7_99461885_-intronic
ADediting_1376955chr7_99461900_-intronic
ADediting_1376956chr7_99461930_-intronic
ADediting_1376957chr7_99461931_-intronic
ADediting_1376958chr7_99462196_-intronic
ADediting_1376959chr7_99462218_-intronic
ADediting_1376960chr7_99462234_-intronic
ADediting_1376961chr7_99462259_-intronic
ADediting_1376962chr7_99462263_-intronic
ADediting_1376963chr7_99462285_-intronic
ADediting_1376964chr7_99462346_-intronic
ADediting_1376965chr7_99462352_-intronic
ADediting_1376966chr7_99462356_-intronic
ADediting_1376967chr7_99462368_-intronic
ADediting_1376968chr7_99462405_-intronic
ADediting_1376969chr7_99462416_-intronic
ADediting_1376970chr7_99462421_-intronic
ADediting_1376971chr7_99462520_-intronic
ADediting_1376972chr7_99462583_-intronic
ADediting_1376973chr7_99462595_-intronic
ADediting_1376974chr7_99462609_-intronic
ADediting_1376975chr7_99462612_-intronic
ADediting_1376976chr7_99462645_-intronic
ADediting_1376977chr7_99462653_-intronic
ADediting_1376978chr7_99462663_-intronic
ADediting_1376979chr7_99462666_-intronic
ADediting_1376980chr7_99462675_-intronic
ADediting_1376981chr7_99462692_-intronic
ADediting_1376982chr7_99462699_-intronic
ADediting_1376983chr7_99462712_-intronic
ADediting_1376984chr7_99462728_-intronic
ADediting_1376985chr7_99462731_-intronic
ADediting_1376986chr7_99462978_-intronic
ADediting_1376987chr7_99463573_-intronic
ADediting_1376988chr7_99463676_-intronic
ADediting_1376989chr7_99463693_-intronic
ADediting_1376990chr7_99463694_-intronic
ADediting_1376991chr7_99463700_-intronic
ADediting_1376992chr7_99463735_-intronic
ADediting_1376993chr7_99464611_-intronic
ADediting_1376994chr7_99465885_-intronic
ADediting_1589240chr7_99461374_-intronic
ADediting_1589241chr7_99461779_-intronic
ADediting_1589242chr7_99463521_-intronic
ADediting_1589243chr7_99463713_-intronic
ADediting_1589244chr7_99463737_-intronic
ADediting_1589245chr7_99464541_-intronic
ADediting_1667626chr7_99461876_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1376932chr7_99459548_-SINEAluName=AluJo
ADediting_1376933chr7_99459626_-SINEAluName=AluJo
ADediting_1376934chr7_99461302_-SINEAluName=FAM
ADediting_1376935chr7_99461312_-SINEAluName=FAM
ADediting_1376936chr7_99461321_-SINEAluName=FAM
ADediting_1376937chr7_99461325_-SINEAluName=FAM
ADediting_1376938chr7_99461334_-SINEAluName=FAM
ADediting_1376939chr7_99461348_-SINEAluName=FAM
ADediting_1376940chr7_99461626_-SINEAluName=AluSz
ADediting_1376941chr7_99461627_-SINEAluName=AluSz
ADediting_1376942chr7_99461641_-SINEAluName=AluSz
ADediting_1376943chr7_99461721_-SINEAluName=AluSx
ADediting_1376944chr7_99461751_-SINEAluName=AluSx
ADediting_1376945chr7_99461782_-SINEAluName=AluSx
ADediting_1376946chr7_99461786_-SINEAluName=AluSx
ADediting_1376947chr7_99461790_-SINEAluName=AluSx
ADediting_1376948chr7_99461796_-SINEAluName=AluSx
ADediting_1376949chr7_99461804_-SINEAluName=AluSx
ADediting_1376950chr7_99461822_-SINEAluName=AluSx
ADediting_1376951chr7_99461851_-SINEAluName=AluSx
ADediting_1376952chr7_99461861_-SINEAluName=AluSx
ADediting_1376953chr7_99461862_-SINEAluName=AluSx
ADediting_1376954chr7_99461885_-SINEAluName=AluSx
ADediting_1376955chr7_99461900_-SINEAluName=AluSx
ADediting_1376956chr7_99461930_-SINEAluName=AluSx
ADediting_1376957chr7_99461931_-SINEAluName=AluSx
ADediting_1376958chr7_99462196_-SINEAluName=AluY
ADediting_1376959chr7_99462218_-SINEAluName=AluY
ADediting_1376960chr7_99462234_-SINEAluName=AluY
ADediting_1376961chr7_99462259_-SINEAluName=AluY
ADediting_1376962chr7_99462263_-SINEAluName=AluY
ADediting_1376963chr7_99462285_-SINEAluName=AluY
ADediting_1376964chr7_99462346_-SINEAluName=AluY
ADediting_1376965chr7_99462352_-SINEAluName=AluY
ADediting_1376966chr7_99462356_-SINEAluName=AluY
ADediting_1376967chr7_99462368_-SINEAluName=AluY
ADediting_1376968chr7_99462405_-SINEAluName=AluY
ADediting_1376969chr7_99462416_-SINEAluName=AluY
ADediting_1376970chr7_99462421_-SINEAluName=AluY
ADediting_1376971chr7_99462520_-SINEAluName=AluSg
ADediting_1376972chr7_99462583_-SINEAluName=AluSg
ADediting_1376973chr7_99462595_-SINEAluName=AluSg
ADediting_1376974chr7_99462609_-SINEAluName=AluSg
ADediting_1376975chr7_99462612_-SINEAluName=AluSg
ADediting_1376976chr7_99462645_-SINEAluName=AluSg
ADediting_1376977chr7_99462653_-SINEAluName=AluSg
ADediting_1376978chr7_99462663_-SINEAluName=AluSg
ADediting_1376979chr7_99462666_-SINEAluName=AluSg
ADediting_1376980chr7_99462675_-SINEAluName=AluSg
ADediting_1376981chr7_99462692_-SINEAluName=AluSg
ADediting_1376982chr7_99462699_-SINEAluName=AluSg
ADediting_1376983chr7_99462712_-SINEAluName=AluSg
ADediting_1376984chr7_99462728_-SINEAluName=AluSg
ADediting_1376985chr7_99462731_-SINEAluName=AluSg
ADediting_1376986chr7_99462978_-SINEMIRName=MIRb
ADediting_1376987chr7_99463573_-SINEAluName=AluSq2
ADediting_1376988chr7_99463676_-SINEAluName=AluSq2
ADediting_1376989chr7_99463693_-SINEAluName=AluSq2
ADediting_1376990chr7_99463694_-SINEAluName=AluSq2
ADediting_1376991chr7_99463700_-SINEAluName=AluSq2
ADediting_1376992chr7_99463735_-SINEAluName=AluSq2
ADediting_1376993chr7_99464611_-SINEAluName=AluYf1
ADediting_1589241chr7_99461779_-SINEAluName=AluSx
ADediting_1589242chr7_99463521_-SINEAluName=AluSq2
ADediting_1589243chr7_99463713_-SINEAluName=AluSq2
ADediting_1589244chr7_99463737_-SINEAluName=AluSq2
ADediting_1589245chr7_99464541_-SINEAluName=AluYf1
ADediting_1667626chr7_99461876_-SINEAluName=AluSx

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RNA A-to-I editing events in the alternative splicing sites for ATP5MF

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ATP5MF

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for ATP5MF

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ATP5MF


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ATP5MF

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ATP5MF

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_1376933chr7_99459626_-0.04771383959403760.1619448331234095.02743549385964e-050.3247356909578960.04061932346664610.167388031463168
CERADediting_1376934chr7_99461302_-0.0004249645495272590.2841616542937482.78366921022094e-060.3719187541572230.1494933180505450.118259484143332
CERADediting_1376936chr7_99461321_-0.0003737464379800770.2867788939334981.85345446999587e-080.439389667458760.1993327198793810.105383181414694
CERADediting_1376938chr7_99461334_-3.39389604632157e-050.3316078525435162.76920008884068e-070.4048407211156120.02340441745088940.185027572845696
CERADediting_1376939chr7_99461348_-0.001249752549155110.2611037292995120.0001413091557501760.3058269410390950.02133568300635160.187851737301204
CERADediting_1376940chr7_99461626_-8.6463033219313e-050.3149727096821564.59531244924188e-050.3263220978650090.03203236643206530.175166930968223
CERADediting_1376942chr7_99461641_-0.0001259396587792030.3079976505614620.0004121379354353440.2847885266348530.05229805252725610.158776788797445
CERADediting_1376943chr7_99461721_-0.009331413104693890.2116226306914321.00770756170538e-060.3868558658803650.02739420191072740.180138180356356
DLPFCADediting_1376945chr7_99461782_-0.007589373121901960.151371902238350.5868015810029410.03098516612718311.38849592282349e-150.4328077076225
DLPFCADediting_1376947chr7_99461790_-0.01233010919502690.1419882295656410.3091197515349830.0579512887908271.37619580233207e-100.354098103933919
DLPFCADediting_1376949chr7_99461804_-0.000400860658362740.1998073395629140.2448928016317980.06624013547133982.34830061495522e-170.45640383764025
DLPFCADediting_1376952chr7_99461861_-0.03115643571061270.1224334580230230.902069463007799-0.007016890417934075.5323178050484e-210.49967505417385
CERADediting_1376956chr7_99461930_-7.41592030621063e-050.3177708126940724.09995251107355e-050.3283229071022290.639874255252616-0.0385097786805228
CERADediting_1376957chr7_99461931_-0.0004981826515317210.2808866620003149.62649000318428e-050.3129986311223170.4230832686665840.0658882688425954
CERADediting_1376958chr7_99462196_-0.006116002799133360.2228838372240512.41974099930071e-050.3373964092338880.8062383952983550.0201940491755118
DLPFCADediting_1376959chr7_99462218_-0.0002667290843388390.2056712738270450.1064618013940440.09186337103017681.09397650231314e-120.389757469591416
CERADediting_1376959chr7_99462218_-0.00966649696453090.2106574264912541.66715335956499e-050.3436398416509210.4653695185845130.0600555730346129
DLPFCADediting_1376971chr7_99462520_-0.009076067553037980.1479723296993830.3605991550151010.05209963114579221.05053484910714e-130.405596997378226
CERADediting_1376972chr7_99462583_-0.01293163785441510.2025384941783877.06448781580607e-050.3186500538551480.315611358976490.0824871527230895
DLPFCADediting_1376978chr7_99462663_-0.01897177011931290.1331925372037920.952819338198785-0.003374063200813732.05376275028253e-260.554734254234277
DLPFCADediting_1376980chr7_99462675_-0.04077419483572650.1162700395904410.2146358666185430.07067678347769191.7616527898514e-100.352153119093208
DLPFCADediting_1376984chr7_99462728_-0.0005289020885055210.1957207207919270.06801967902981640.1037852237386418.31372377061767e-200.486298505012827
CERADediting_1376984chr7_99462728_-0.0005540573620078110.2786741189974921.87192487212652e-070.4100903006582550.5225163559084650.0526165925076417
CERADediting_1376989chr7_99463693_-0.00014927524539920.3047871237632352.36641473695395e-080.4364220505424790.2978049865198460.0855695054432472
CERADediting_1376990chr7_99463694_-0.1124411379201840.1301406755455050.000123425510320840.308376067592120.007100593331232530.218965866259862
CERADediting_1376991chr7_99463700_-8.01942068226431e-050.3163481344905427.10548219177042e-090.4507682335644290.05675412460686690.155910505574842

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC8.88702604968196e-360.6306194109601949.57022252341387e-500.7147121534448510.36489773780904-0.0516356899258103
AC4.52459216521346e-600.8125643811820452.41202939307624e-410.7207171614669277.26852799152711e-170.495093249070529
PCC4.68581383683582e-260.668099035787869.26249776427945e-280.6846451689491330.1145371923966990.114564766946726
CER0.0001091016413414760.3106799442757850.005001571313259050.228064559017080.5941718337676750.0438488443326454
TCX5.37779817684702e-140.5644395406437544.00253849780976e-210.6729689812277950.000765968702736362-0.271817802797209
FP2.88816617161523e-050.307978724685475.61770825238388e-090.4194504384238050.00387380847924819-0.215453683695103
IFG0.1051630987271410.3317948061070810.1993272309344260.2656526917584370.0374724719160932-0.41823515504794
PG9.53095171204871e-220.6274066357803177.03420615205242e-140.513055689090280.0181512691812288-0.173085501392858
STG1.15821822899854e-110.6568820040308565.6269716413328e-090.5836999949128070.194396031286015-0.143002694664981

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Relation with AD stages for ATP5MF

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_1376991chr7_99463700_-0.001438219701704380.302942076554441

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
PG1.2950683858826e-06-0.346218632924067

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RelatedDrugs for ATP5MF

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP5MF

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource