ADeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for HS6ST1

check button Gene summary
Gene informationGene symbol

HS6ST1

Gene ID

9394

Gene nameheparan sulfate 6-O-sulfotransferase 1
SynonymsHH15|HS6ST
Cytomap

2q14.3

Type of geneprotein-coding
Descriptionheparan-sulfate 6-O-sulfotransferase 1HS6ST-1heparan-sulfate 6-sulfotransferase
Modification date20200313
UniProtAcc

O60243,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

Top

RNA A-to-I events for HS6ST1

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_810592(128240159, -), ADediting_810593(128240169, -), ADediting_810594(128245009, -), ADediting_810595(128245252, -), ADediting_810596(128251037, -), ADediting_810597(128251077, -), ADediting_810598(128253339, -), ADediting_810599(128258028, -), ADediting_810600(128258140, -), ADediting_810601(128258142, -), ADediting_810602(128258152, -), ADediting_810603(128258155, -), ADediting_810604(128258156, -), ADediting_810605(128258164, -), ADediting_810606(128258177, -), ADediting_810607(128258181, -), ADediting_810608(128258195, -), ADediting_810609(128258202, -), ADediting_810610(128259979, -), ADediting_810611(128262288, -), ADediting_810612(128262290, -), ADediting_810613(128262291, -), ADediting_810614(128262299, -), ADediting_810615(128262418, -), ADediting_810616(128262436, -), ADediting_810617(128262439, -), ADediting_810618(128262450, -), ADediting_810619(128262469, -), ADediting_810620(128262496, -), ADediting_810621(128262504, -), ADediting_810622(128263477, -), ADediting_810623(128263488, -), ADediting_810624(128263661, -), ADediting_810625(128263669, -), ADediting_810626(128270689, -), ADediting_810627(128276224, -), ADediting_810628(128276243, -), ADediting_810629(128276260, -), ADediting_810630(128276265, -), ADediting_810631(128279695, -), ADediting_810632(128279707, -), ADediting_810633(128279713, -), ADediting_810634(128291473, -),

Top

RNA editing positional annotations for HS6ST1 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_810592chr2_128240159_-intergenic
ADediting_810593chr2_128240169_-intergenic
ADediting_810594chr2_128245009_-intergenic
ADediting_810595chr2_128245252_-intergenic
ADediting_810596chr2_128251037_-intergenic
ADediting_810597chr2_128251077_-intergenic
ADediting_810598chr2_128253339_-intergenic
ADediting_810599chr2_128258028_-intergenic
ADediting_810600chr2_128258140_-intergenic
ADediting_810601chr2_128258142_-intergenic
ADediting_810602chr2_128258152_-intergenic
ADediting_810603chr2_128258155_-intergenic
ADediting_810604chr2_128258156_-intergenic
ADediting_810605chr2_128258164_-intergenic
ADediting_810606chr2_128258177_-intergenic
ADediting_810607chr2_128258181_-intergenic
ADediting_810608chr2_128258195_-intergenic
ADediting_810609chr2_128258202_-intergenic
ADediting_810610chr2_128259979_-intergenic
ADediting_810611chr2_128262288_-intergenic
ADediting_810612chr2_128262290_-intergenic
ADediting_810613chr2_128262291_-intergenic
ADediting_810614chr2_128262299_-intergenic
ADediting_810615chr2_128262418_-intergenic
ADediting_810616chr2_128262436_-intergenic
ADediting_810617chr2_128262439_-intergenic
ADediting_810618chr2_128262450_-intergenic
ADediting_810619chr2_128262469_-intergenic
ADediting_810620chr2_128262496_-intergenic
ADediting_810621chr2_128262504_-intergenic
ADediting_810622chr2_128263477_-intergenic
ADediting_810623chr2_128263488_-intergenic
ADediting_810624chr2_128263661_-intergenic
ADediting_810625chr2_128263669_-intergenic
ADediting_810626chr2_128270689_-intronic
ADediting_810627chr2_128276224_-intronic
ADediting_810628chr2_128276243_-intronic
ADediting_810629chr2_128276260_-intronic
ADediting_810630chr2_128276265_-intronic
ADediting_810631chr2_128279695_-intronic
ADediting_810632chr2_128279707_-intronic
ADediting_810633chr2_128279713_-intronic
ADediting_810634chr2_128291473_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_810592chr2_128240159_-SINEAluName=AluSq2
ADediting_810593chr2_128240169_-SINEAluName=AluSq2
ADediting_810594chr2_128245009_-SINEAluName=AluSx1
ADediting_810595chr2_128245252_-SINEAluName=AluSp
ADediting_810596chr2_128251037_-SINEAluName=AluSq2
ADediting_810597chr2_128251077_-SINEAluName=AluSq2
ADediting_810598chr2_128253339_-SINEAluName=AluSq
ADediting_810599chr2_128258028_-SINEAluName=AluSx
ADediting_810600chr2_128258140_-SINEAluName=AluSx
ADediting_810601chr2_128258142_-SINEAluName=AluSx
ADediting_810602chr2_128258152_-SINEAluName=AluSx
ADediting_810603chr2_128258155_-SINEAluName=AluSx
ADediting_810604chr2_128258156_-SINEAluName=AluSx
ADediting_810605chr2_128258164_-SINEAluName=AluSx
ADediting_810606chr2_128258177_-SINEAluName=AluSx
ADediting_810607chr2_128258181_-SINEAluName=AluSx
ADediting_810608chr2_128258195_-SINEAluName=AluSx
ADediting_810609chr2_128258202_-SINEAluName=AluSx
ADediting_810610chr2_128259979_-SINEAluName=AluSx1
ADediting_810611chr2_128262288_-SINEAluName=AluSx1
ADediting_810612chr2_128262290_-SINEAluName=AluSx1
ADediting_810613chr2_128262291_-SINEAluName=AluSx1
ADediting_810614chr2_128262299_-SINEAluName=AluSx1
ADediting_810615chr2_128262418_-SINEAluName=AluSx1
ADediting_810616chr2_128262436_-SINEAluName=AluSx1
ADediting_810617chr2_128262439_-SINEAluName=AluSx1
ADediting_810618chr2_128262450_-SINEAluName=AluSx1
ADediting_810619chr2_128262469_-SINEAluName=AluSx1
ADediting_810620chr2_128262496_-SINEAluName=AluSx1
ADediting_810621chr2_128262504_-SINEAluName=AluSx1
ADediting_810622chr2_128263477_-SINEAluName=AluSz
ADediting_810623chr2_128263488_-SINEAluName=AluSz
ADediting_810624chr2_128263661_-SINEAluName=AluSz
ADediting_810625chr2_128263669_-SINEAluName=AluSz
ADediting_810627chr2_128276224_-SINEAluName=AluSx
ADediting_810628chr2_128276243_-SINEAluName=AluSx
ADediting_810629chr2_128276260_-SINEAluName=AluSx
ADediting_810630chr2_128276265_-SINEAluName=AluSx
ADediting_810631chr2_128279695_-SINEAluName=FRAM
ADediting_810632chr2_128279707_-SINEAluName=FRAM
ADediting_810633chr2_128279713_-SINEAluName=FRAM

Top

RNA A-to-I editing events in the alternative splicing sites for HS6ST1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for HS6ST1

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

Top

Protein coding region RNA A-to-I editings for HS6ST1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for HS6ST1


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000136720.7ENST00000259241.7HS6ST1-201hsa-miR-5581-3pchr21282660451282660517mer-1a128266037128266059143-18.74
ADediting_1337757chr7_5495852_-ENSG00000136720.7ENST00000259241.7HS6ST1-201hsa-miR-589-3pchr21282669121282669187mer-m8128266911128266933148-21.22
ADediting_1535953chr14_101045971_+ENSG00000136720.7ENST00000259241.7HS6ST1-201hsa-miR-381-3pchr21282669571282669637mer-m8128266956128266976150-16.81
ADediting_496066chr15_66496985_-ENSG00000136720.7ENST00000259241.7HS6ST1-201hsa-miR-4512chr21282674821282674898mer-1a128267482128267501149-19.96
ADediting_98289chr1_32086992_+ENSG00000136720.7ENST00000259241.7HS6ST1-201hsa-miR-5585-3pchr21282659051282659117mer-m8128265904128265925145-22.28

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for HS6ST1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for HS6ST1

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_810602chr2_128258152_-0.02929278456018910.1780225943178318.51106698653775e-050.3152613495329980.1026460059470870.133784607792158
DLPFCADediting_810612chr2_128262290_-0.6268837762359120.02771628761209510.85867659832951-0.01015383301506483.62131214038158e-090.327185766030923
DLPFCADediting_810614chr2_128262299_-0.2953996634294540.05961662588858660.9195144641461830.005762220304871358.66234404811731e-110.357709098717748
DLPFCADediting_810619chr2_128262469_-0.09462094795157630.09510430206068640.603794392098457-0.02958755111819857.4741732679135e-130.392390952973482
DLPFCADediting_810625chr2_128263669_-0.3016162073268480.05885585461083340.8715685225349510.009219085350853662.76003650037261e-080.309050488130435
DLPFCADediting_810630chr2_128276265_-0.2029621452224920.0725081909374650.896199183812419-0.007439820634202285.42866308607891e-090.323665595055505

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.82592400214533e-670.7890647577823759.83846746568525e-800.8290211396641413.50827701056928e-080.306825975642496
AC1.25765694694948e-600.8147045619670881.27758765453358e-490.7666087250175625.54815077178076e-140.451856939958749
PCC5.23939515782703e-380.7652754542926122.57649738457303e-500.8323106510225610.0007471777123412330.241918482017457
CER1.45724166035366e-160.6085127284776317.21324740312702e-370.8148268725346232.39285400830696e-060.374190178150747
TCX8.28645531000251e-200.6559040740159463.36124519061971e-200.661103131567180.8315159505929250.0175167976423252
FP2.1005435035292e-130.5142542927671557.37456451032688e-140.5225210038942014.36567237596593e-070.367909478387653
IFG7.22744079576134e-060.7685085734516851.16907215059453e-060.8057956321539530.2024958618628140.263857205882073
STG7.91269025915844e-220.822854463033044.20675860405995e-160.7454201825144060.01970738640105980.254045343749043

Top

Relation with AD stages for HS6ST1

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_810602chr2_128258152_-6.86528295151692e-050.373453382278212

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER2.64693964758256e-090.534045853477015
TCX3.67106505213707e-050.389540038432273

Top

RelatedDrugs for HS6ST1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HS6ST1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
HS6ST1C0342384Idiopathic hypogonadotropic hypogonadism3GENOMICS_ENGLAND
HS6ST1C3553977HYPOGONADOTROPIC HYPOGONADISM 15 WITH OR WITHOUT ANOSMIA1CTD_human;UNIPROT