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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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Gene summary for PLAA |
 Gene summary |
| Gene information | Gene symbol | PLAA | Gene ID | 9373 |
| Gene name | phospholipase A2 activating protein | |
| Synonyms | DOA1|NDMSBA|PLA2P|PLAP | |
| Cytomap | 9p21.2 | |
| Type of gene | protein-coding | |
| Description | phospholipase A-2-activating proteinDOA1 homolog | |
| Modification date | 20200313 | |
| UniProtAcc | Q9Y263, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for PLAA |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1460254(26906556, -), ADediting_1460255(26906560, -), ADediting_1460256(26906565, -), ADediting_1460257(26906572, -), ADediting_1460258(26906592, -), ADediting_1460259(26906598, -), ADediting_1460260(26906601, -), ADediting_1460261(26906607, -), ADediting_1460262(26906610, -), ADediting_1460263(26906626, -), ADediting_1460264(26906632, -), ADediting_1460265(26906644, -), ADediting_1460266(26906659, -), ADediting_1460267(26906719, -), ADediting_1460268(26907325, -), ADediting_1460269(26907340, -), ADediting_1460270(26907362, -), ADediting_1460271(26907401, -), ADediting_1460272(26907417, -), ADediting_1460273(26907420, -), ADediting_1460274(26911291, -), ADediting_1460275(26929059, -), ADediting_1460276(26929104, -), ADediting_1460277(26930309, -), ADediting_1460278(26930314, -), ADediting_1460279(26930375, -), ADediting_1460280(26930694, -), ADediting_1460281(26930856, -), ADediting_1460282(26931975, -), ADediting_1460283(26932041, -), ADediting_1460284(26932918, -), ADediting_1460285(26932969, -), ADediting_1460286(26933013, -), ADediting_1460287(26933040, -), ADediting_1460288(26933096, -), ADediting_1460289(26933168, -), ADediting_1460290(26933185, -), ADediting_1460291(26933205, -), ADediting_1460292(26934558, -), ADediting_1460293(26934579, -), ADediting_1460294(26934604, -), ADediting_1460295(26934617, -), ADediting_1460296(26934618, -), ADediting_1460297(26934640, -), ADediting_1460298(26934675, -), ADediting_1460299(26934676, -), ADediting_1460300(26934758, -), ADediting_1593353(26906533, -), ADediting_1593354(26906603, -), ADediting_1593355(26906631, -), ADediting_1593356(26907365, -), ADediting_1593357(26907371, -), ADediting_1593358(26907429, -), ADediting_1672662(26933916, -), ADediting_1672663(26933986, -), ADediting_1672664(26933991, -), ADediting_1672665(26934008, -), |
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RNA editing positional annotations for PLAA using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1460254 | chr9_26906556_- | intronic |
| ADediting_1460255 | chr9_26906560_- | intronic |
| ADediting_1460256 | chr9_26906565_- | intronic |
| ADediting_1460257 | chr9_26906572_- | intronic |
| ADediting_1460258 | chr9_26906592_- | intronic |
| ADediting_1460259 | chr9_26906598_- | intronic |
| ADediting_1460260 | chr9_26906601_- | intronic |
| ADediting_1460261 | chr9_26906607_- | intronic |
| ADediting_1460262 | chr9_26906610_- | intronic |
| ADediting_1460263 | chr9_26906626_- | intronic |
| ADediting_1460264 | chr9_26906632_- | intronic |
| ADediting_1460265 | chr9_26906644_- | intronic |
| ADediting_1460266 | chr9_26906659_- | intronic |
| ADediting_1460267 | chr9_26906719_- | intronic |
| ADediting_1460268 | chr9_26907325_- | intronic |
| ADediting_1460269 | chr9_26907340_- | intronic |
| ADediting_1460270 | chr9_26907362_- | intronic |
| ADediting_1460271 | chr9_26907401_- | intronic |
| ADediting_1460272 | chr9_26907417_- | intronic |
| ADediting_1460273 | chr9_26907420_- | intronic |
| ADediting_1460274 | chr9_26911291_- | intronic |
| ADediting_1460275 | chr9_26929059_- | intronic |
| ADediting_1460276 | chr9_26929104_- | intronic |
| ADediting_1460277 | chr9_26930309_- | intronic |
| ADediting_1460278 | chr9_26930314_- | intronic |
| ADediting_1460279 | chr9_26930375_- | intronic |
| ADediting_1460280 | chr9_26930694_- | intronic |
| ADediting_1460281 | chr9_26930856_- | intronic |
| ADediting_1460282 | chr9_26931975_- | intronic |
| ADediting_1460283 | chr9_26932041_- | intronic |
| ADediting_1460284 | chr9_26932918_- | intronic |
| ADediting_1460285 | chr9_26932969_- | intronic |
| ADediting_1460286 | chr9_26933013_- | intronic |
| ADediting_1460287 | chr9_26933040_- | intronic |
| ADediting_1460288 | chr9_26933096_- | intronic |
| ADediting_1460289 | chr9_26933168_- | intronic |
| ADediting_1460290 | chr9_26933185_- | intronic |
| ADediting_1460291 | chr9_26933205_- | intronic |
| ADediting_1460292 | chr9_26934558_- | intronic |
| ADediting_1460293 | chr9_26934579_- | intronic |
| ADediting_1460294 | chr9_26934604_- | intronic |
| ADediting_1460295 | chr9_26934617_- | intronic |
| ADediting_1460296 | chr9_26934618_- | intronic |
| ADediting_1460297 | chr9_26934640_- | intronic |
| ADediting_1460298 | chr9_26934675_- | intronic |
| ADediting_1460299 | chr9_26934676_- | intronic |
| ADediting_1460300 | chr9_26934758_- | intronic |
| ADediting_1593353 | chr9_26906533_- | intronic |
| ADediting_1593354 | chr9_26906603_- | intronic |
| ADediting_1593355 | chr9_26906631_- | intronic |
| ADediting_1593356 | chr9_26907365_- | intronic |
| ADediting_1593357 | chr9_26907371_- | intronic |
| ADediting_1593358 | chr9_26907429_- | intronic |
| ADediting_1672662 | chr9_26933916_- | intronic |
| ADediting_1672663 | chr9_26933986_- | intronic |
| ADediting_1672664 | chr9_26933991_- | intronic |
| ADediting_1672665 | chr9_26934008_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1460254 | chr9_26906556_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460255 | chr9_26906560_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460256 | chr9_26906565_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460257 | chr9_26906572_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460258 | chr9_26906592_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460259 | chr9_26906598_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460260 | chr9_26906601_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460261 | chr9_26906607_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460262 | chr9_26906610_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460263 | chr9_26906626_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460264 | chr9_26906632_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460265 | chr9_26906644_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460266 | chr9_26906659_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460267 | chr9_26906719_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460268 | chr9_26907325_- | SINE | Alu | Name=AluY |
| ADediting_1460269 | chr9_26907340_- | SINE | Alu | Name=AluY |
| ADediting_1460270 | chr9_26907362_- | SINE | Alu | Name=AluY |
| ADediting_1460271 | chr9_26907401_- | SINE | Alu | Name=AluY |
| ADediting_1460272 | chr9_26907417_- | SINE | Alu | Name=AluY |
| ADediting_1460273 | chr9_26907420_- | SINE | Alu | Name=AluY |
| ADediting_1460274 | chr9_26911291_- | SINE | Alu | Name=AluSg |
| ADediting_1460275 | chr9_26929059_- | SINE | Alu | Name=AluJo |
| ADediting_1460276 | chr9_26929104_- | SINE | Alu | Name=AluJo |
| ADediting_1460277 | chr9_26930309_- | SINE | Alu | Name=AluY |
| ADediting_1460278 | chr9_26930314_- | SINE | Alu | Name=AluY |
| ADediting_1460279 | chr9_26930375_- | SINE | Alu | Name=AluY |
| ADediting_1460280 | chr9_26930694_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460281 | chr9_26930856_- | SINE | Alu | Name=AluSq2 |
| ADediting_1460282 | chr9_26931975_- | SINE | Alu | Name=AluSx1 |
| ADediting_1460283 | chr9_26932041_- | SINE | Alu | Name=AluSx1 |
| ADediting_1460284 | chr9_26932918_- | SINE | Alu | Name=AluSx1 |
| ADediting_1460285 | chr9_26932969_- | SINE | Alu | Name=AluSx1 |
| ADediting_1460286 | chr9_26933013_- | SINE | Alu | Name=AluSc |
| ADediting_1460287 | chr9_26933040_- | SINE | Alu | Name=AluSc |
| ADediting_1460288 | chr9_26933096_- | SINE | Alu | Name=AluSc |
| ADediting_1460289 | chr9_26933168_- | SINE | Alu | Name=AluSc |
| ADediting_1460290 | chr9_26933185_- | SINE | Alu | Name=AluSc |
| ADediting_1460291 | chr9_26933205_- | SINE | Alu | Name=AluSc |
| ADediting_1460292 | chr9_26934558_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460293 | chr9_26934579_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460294 | chr9_26934604_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460295 | chr9_26934617_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460296 | chr9_26934618_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460297 | chr9_26934640_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460298 | chr9_26934675_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460299 | chr9_26934676_- | SINE | Alu | Name=AluSz6 |
| ADediting_1460300 | chr9_26934758_- | SINE | Alu | Name=AluSz6 |
| ADediting_1593353 | chr9_26906533_- | SINE | Alu | Name=AluSq2 |
| ADediting_1593354 | chr9_26906603_- | SINE | Alu | Name=AluSq2 |
| ADediting_1593355 | chr9_26906631_- | SINE | Alu | Name=AluSq2 |
| ADediting_1593356 | chr9_26907365_- | SINE | Alu | Name=AluY |
| ADediting_1593357 | chr9_26907371_- | SINE | Alu | Name=AluY |
| ADediting_1593358 | chr9_26907429_- | SINE | Alu | Name=AluY |
| ADediting_1672662 | chr9_26933916_- | SINE | Alu | Name=AluJr |
| ADediting_1672663 | chr9_26933986_- | SINE | Alu | Name=AluJr |
| ADediting_1672664 | chr9_26933991_- | SINE | Alu | Name=AluJr |
| ADediting_1672665 | chr9_26934008_- | SINE | Alu | Name=AluJr |
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RNA A-to-I editing events in the alternative splicing sites for PLAA |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PLAA |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for PLAA |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for PLAA |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000137055.15 | ENST00000397292.8 | PLAA-201 | hsa-miR-5688 | chr9 | 26903741 | 26903747 | 7mer-m8 | 26903740 | 26903759 | 151 | -11.74 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000137055.15 | ENST00000397292.8 | PLAA-201 | hsa-miR-4477b | chr9 | 26904592 | 26904599 | 8mer-1a | 26904592 | 26904614 | 147 | -8.66 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000137055.15 | ENST00000397292.8 | PLAA-201 | hsa-miR-4477b | chr9 | 26904592 | 26904599 | 8mer-1a | 26904592 | 26904614 | 147 | -8.66 |
| ADediting_286380 | chr11_79422188_- | ENSG00000137055.15 | ENST00000397292.8 | PLAA-201 | hsa-miR-5579-3p | chr9 | 26905274 | 26905280 | 7mer-m8 | 26905273 | 26905294 | 140 | -7.8 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000137055.15 | ENST00000397292.8 | PLAA-201 | hsa-miR-4775 | chr9 | 26903971 | 26903977 | 7mer-m8 | 26903970 | 26903992 | 149 | -5.72 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for PLAA |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for PLAA |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1460266 | chr9_26906659_- | 3.46181150354388e-05 | 0.331265227926055 | 2.04948265229487e-06 | 0.376498241401197 | 0.573294705325725 | -0.0463485698741446 |
| CER | ADediting_1460267 | chr9_26906719_- | 0.000639764685038993 | 0.275650996892479 | 0.000126476990722365 | 0.307917688934433 | 0.767873042427187 | 0.0242992805413396 |
| CER | ADediting_1460269 | chr9_26907340_- | 0.00431651825864123 | 0.231789277041248 | 3.15200412262471e-06 | 0.370039983299385 | 0.334996704385436 | 0.0792573955077368 |
| DLPFC | ADediting_1460271 | chr9_26907401_- | 0.25056909265377 | 0.0654514220145763 | 0.0774884528264626 | -0.100422792087205 | 1.27214724241227e-27 | 0.565717953881244 |
| DLPFC | ADediting_1460272 | chr9_26907417_- | 0.0577493955304292 | 0.107897223309137 | 0.631491936890745 | -0.0273464171797327 | 2.28202721244691e-08 | 0.310801079549161 |
| DLPFC | ADediting_1460273 | chr9_26907420_- | 0.409344592947181 | 0.0470235884383286 | 0.201990456873221 | -0.0726640320460512 | 4.45638763367811e-10 | 0.344721507986033 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 3.32421958114377e-99 | 0.875318692681755 | 3.49885522808397e-85 | 0.843630147371846 | 0.603236122309134 | 0.029633182731241 |
| AC | 5.00652424257611e-115 | 0.936703265569054 | 1.95945888598151e-61 | 0.817763787272557 | 4.45885515870484e-16 | 0.483870435057164 |
| PCC | 3.42726572836133e-74 | 0.910005161150771 | 1.35638677440186e-57 | 0.861731872954512 | 0.00552265847196613 | 0.200060711773953 |
| CER | 5.87964958484472e-48 | 0.87280558712958 | 2.48785876486891e-18 | 0.635336864907049 | 0.146836447630709 | 0.11903124649587 |
| TCX | 3.21569756993392e-54 | 0.896600758505286 | 3.78166791227102e-16 | 0.60184053860191 | 0.0646434201759067 | 0.151261495392151 |
| FP | 1.41289607275519e-38 | 0.785832028803588 | 5.37543259540039e-23 | 0.652851921446969 | 0.00892801657594418 | 0.195470260891668 |
| IFG | 1.13482914857174e-05 | 0.75806903518133 | 0.00207932736518588 | 0.586082134744961 | 0.890805364202141 | 0.0289326139990606 |
| PG | 5.35195512280612e-61 | 0.878719373108355 | 4.99193656374262e-25 | 0.664156015978751 | 0.758921216956251 | 0.0226526536453956 |
| STG | 4.55237291867014e-20 | 0.802343370744952 | 2.35133537876716e-10 | 0.623626458605158 | 0.774745924605962 | -0.0316910017108208 |
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Relation with AD stages for PLAA |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for PLAA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLAA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PLAA | C0431350 | Primary microcephaly | 2 | GENOMICS_ENGLAND |
| PLAA | C3714756 | Intellectual Disability | 2 | GENOMICS_ENGLAND |
| PLAA | C4479631 | NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE MICROCEPHALY, SPASTICITY, AND BRAIN ANOMALIES | 2 | UNIPROT |
| PLAA | C0021368 | Inflammation | 1 | CTD_human |
| PLAA | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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