ADeditome Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for TADA2B

check button Gene summary
Gene informationGene symbol

TADA2B

Gene ID

93624

Gene nametranscriptional adaptor 2B
SynonymsADA2(beta)|ADA2B
Cytomap

4p16.1

Type of geneprotein-coding
Descriptiontranscriptional adapter 2-betaADA2-betaADA2-like protein betatranscriptional adaptor 2 (ADA2 homolog, yeast)-beta
Modification date20200313
UniProtAcc

Q86TJ2,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

Top

RNA A-to-I events for TADA2B

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1143775(7057533, +), ADediting_1143776(7057534, +), ADediting_1143777(7057555, +), ADediting_1143778(7057556, +), ADediting_1143779(7057578, +), ADediting_1143780(7057601, +), ADediting_1143781(7057611, +), ADediting_1143782(7057622, +), ADediting_1143783(7057666, +), ADediting_1143784(7057672, +), ADediting_1143785(7057676, +), ADediting_1143786(7057696, +), ADediting_1143787(7057699, +), ADediting_1143788(7057708, +), ADediting_1143789(7057774, +),

Top

RNA editing positional annotations for TADA2B using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1143775chr4_7057533_+UTR3
ADediting_1143776chr4_7057534_+UTR3
ADediting_1143777chr4_7057555_+UTR3
ADediting_1143778chr4_7057556_+UTR3
ADediting_1143779chr4_7057578_+UTR3
ADediting_1143780chr4_7057601_+UTR3
ADediting_1143781chr4_7057611_+UTR3
ADediting_1143782chr4_7057622_+UTR3
ADediting_1143783chr4_7057666_+UTR3
ADediting_1143784chr4_7057672_+UTR3
ADediting_1143785chr4_7057676_+UTR3
ADediting_1143786chr4_7057696_+UTR3
ADediting_1143787chr4_7057699_+UTR3
ADediting_1143788chr4_7057708_+UTR3
ADediting_1143789chr4_7057774_+UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1143775chr4_7057533_+SINEAluName=AluSc
ADediting_1143776chr4_7057534_+SINEAluName=AluSc
ADediting_1143777chr4_7057555_+SINEAluName=AluSc
ADediting_1143778chr4_7057556_+SINEAluName=AluSc
ADediting_1143779chr4_7057578_+SINEAluName=AluSc
ADediting_1143780chr4_7057601_+SINEAluName=AluSc
ADediting_1143781chr4_7057611_+SINEAluName=AluSc
ADediting_1143782chr4_7057622_+SINEAluName=AluSc
ADediting_1143783chr4_7057666_+SINEAluName=AluSc
ADediting_1143784chr4_7057672_+SINEAluName=AluSc
ADediting_1143785chr4_7057676_+SINEAluName=AluSc
ADediting_1143786chr4_7057696_+SINEAluName=AluSc
ADediting_1143787chr4_7057699_+SINEAluName=AluSc
ADediting_1143788chr4_7057708_+SINEAluName=AluSc
ADediting_1143789chr4_7057774_+SINEAluName=AluSc

Top

RNA A-to-I editing events in the alternative splicing sites for TADA2B

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for TADA2B

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome IDChrPositoingSkipped exonENSGENSTs

Top

Protein coding region RNA A-to-I editings for TADA2B

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for TADA2B

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1143775chr4_7057533_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-513a-5pchr4705752770575337mer-m870575177057534144-16.68
ADediting_1143775chr4_7057533_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-638chr4705753270575387mer-1a70575147057538157-32.92
ADediting_1143776chr4_7057534_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-8052chr4705753270575387mer-1a70575207057538140-24.15
ADediting_1143778chr4_7057556_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-3176chr4705754970575557mer-m870575387057556140-15.24
ADediting_1143778chr4_7057556_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-3922-3pchr4705754970575557mer-m870575357057556141-19.73
ADediting_1143779chr4_7057578_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-378a-5pchr4705757370575797mer-m870575587057580151-21.91
ADediting_1143780chr4_7057601_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-3190-5pchr4705759470576007mer-m870575827057601150-18.87
ADediting_1143781chr4_7057611_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-3158-3pchr4705760870576147mer-m870575957057615150-20.06
ADediting_1143781chr4_7057611_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-412-3pchr4705760470576107mer-m870575897057611151-16.53
ADediting_1143781chr4_7057611_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-6754-3pchr4705760470576107mer-m870575917057611144-15.76
ADediting_1143782chr4_7057622_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-374b-3pchr4705761970576268mer-1a70576017057626146-14.59
ADediting_1143783chr4_7057666_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-140-3pchr4705766170576677mer-m870576487057668163-23.48
ADediting_1143785chr4_7057676_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-1207-3pchr4705766970576757mer-m870576587057676145-13.53
ADediting_1143785chr4_7057676_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-646chr4705767170576777mer-m870576597057678148-22.3
ADediting_1143786chr4_7057696_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-3162-3pchr4705768970576957mer-m870576777057696157-26.45
ADediting_1143788chr4_7057708_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-3155achr4705770570577117mer-m870576917057712149-24.05
ADediting_1143788chr4_7057708_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-3155bchr4705770570577117mer-m870576947057712149-22.89
ADediting_1143788chr4_7057708_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-484chr4705770570577117mer-m870576917057712151-23.14
ADediting_1143789chr4_7057774_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-6838-3pchr4705777170577777mer-m870577607057778168-24.31

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1143775chr4_7057533_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-10399-5pchr4705752870575347mer-m870575147057535144-10.39
ADediting_1143775chr4_7057533_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-6504-3pchr4705752870575347mer-m870575147057535152-15.11
ADediting_1143775chr4_7057533_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-7151-3pchr4705752670575338mer-1a70575097057533145-20.4
ADediting_1143776chr4_7057534_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-10399-5pchr4705752870575347mer-m870575147057535144-10.39
ADediting_1143776chr4_7057534_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-5089-5pchr4705753270575387mer-m870575177057539148-14.13
ADediting_1143776chr4_7057534_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-6504-3pchr4705752870575347mer-m870575147057535152-15.11
ADediting_1143777chr4_7057555_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-6878-3pchr4705754870575558mer-1a70575357057555142-14.14
ADediting_1143780chr4_7057601_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-4716-5pchr4705759970576057mer-m870575857057606140-11.3
ADediting_1143780chr4_7057601_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-4781-3pchr4705759770576037mer-m870575837057604140-14.54
ADediting_1143781chr4_7057611_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-6823-5pchr4705760970576157mer-m870575967057616143-17.07
ADediting_1143782chr4_7057622_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-6832-5pchr4705761670576227mer-m870576017057623140-18.87
ADediting_1143783chr4_7057666_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-7151-3pchr4705765970576657mer-m870576457057666143-18.9
ADediting_1143783chr4_7057666_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-8052chr4705766570576717mer-1a70576537057671143-23.66
ADediting_1143785chr4_7057676_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-562chr4705767270576787mer-m870576597057679151-14.2
ADediting_1143785chr4_7057676_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-5697chr4705767370576797mer-m870576597057680146-18.01
ADediting_1143786chr4_7057696_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-5571-5pchr4705769470577007mer-m870576797057701150-26.87
ADediting_1143787chr4_7057699_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-5571-5pchr4705769470577007mer-m870576797057701150-26.87
ADediting_1143788chr4_7057708_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-498-5pchr4705770170577077mer-m870576867057708142-10.67
ADediting_1143789chr4_7057774_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-431-5pchr4705777070577767mer-m870577597057777147-15.62

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1391023chr8_140732605_-ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-151a-3pchr4705588370558897mer-m870558697055890157-19
ADediting_1391023chr8_140732605_-ENSG00000173011.12ENST00000515646.1TADA2B-205hsa-miR-151a-3pchr4705588370558897mer-m870558697055890157-19
ADediting_291761chr11_93733708_-ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-1304-3pchr4705697270569787mer-m870569567056979162-27.2
ADediting_496066chr15_66496985_-ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-4512chr4705692770569348mer-1a70569147056934145-19.93
ADediting_843620chr2_207754818_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-4775chr4705559370555997mer-m870555797055600152-10.32
ADediting_843620chr2_207754818_+ENSG00000173011.12ENST00000515646.1TADA2B-205hsa-miR-4775chr4705559370555997mer-m870555797055600152-10.32

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-5688chr4705690570569128mer-1a70568917056912145-11.65
ADediting_1337758chr7_5495892_-ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-589-5pchr4705634670563527mer-m870563317056353144-16.9
ADediting_1337758chr7_5495892_-ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-589-5pchr4705686570568728mer-1a70568517056872153-22.87
ADediting_1337758chr7_5495892_-ENSG00000173011.12ENST00000515646.1TADA2B-205hsa-miR-589-5pchr4705634670563527mer-m870563317056353144-16.9
ADediting_1643790chr3_121049689_+ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-5682chr4705683170568388mer-1a70568177056838142-13.56
ADediting_496066chr15_66496985_-ENSG00000173011.12ENST00000310074.8TADA2B-201hsa-miR-4512chr4705587470558807mer-m870558617055881149-16.82
ADediting_496066chr15_66496985_-ENSG00000173011.12ENST00000515646.1TADA2B-205hsa-miR-4512chr4705587470558807mer-m870558617055881149-16.82

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for TADA2B

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000310074.8protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1143775ENST00000310074.8chr4_7057533_+3950-1617.20-1616.90-1633.20
ADediting_1143776ENST00000310074.8chr4_7057534_+3951-1616.90-1616.90-1633.20
ADediting_1143777ENST00000310074.8chr4_7057555_+3972-1616.90-1616.90-1633.20
ADediting_1143778ENST00000310074.8chr4_7057556_+3973-1620.50-1616.90-1633.20
ADediting_1143779ENST00000310074.8chr4_7057578_+3995-1618.80-1616.90-1633.20
ADediting_1143780ENST00000310074.8chr4_7057601_+4018-1617.20-1616.90-1633.20
ADediting_1143781ENST00000310074.8chr4_7057611_+4028-1617.50-1616.90-1633.20
ADediting_1143782ENST00000310074.8chr4_7057622_+4039-1616.90-1616.90-1633.20
ADediting_1143783ENST00000310074.8chr4_7057666_+4083-1616.60-1616.90-1633.20
ADediting_1143784ENST00000310074.8chr4_7057672_+4089-1616.20-1616.90-1633.20
ADediting_1143785ENST00000310074.8chr4_7057676_+4093-1616.80-1616.90-1633.20
ADediting_1143786ENST00000310074.8chr4_7057696_+4113-1616.00-1616.90-1633.20
ADediting_1143787ENST00000310074.8chr4_7057699_+4116-1617.40-1616.90-1633.20
ADediting_1143788ENST00000310074.8chr4_7057708_+4125-1617.20-1616.90-1633.20
ADediting_1143789ENST00000310074.8chr4_7057774_+4191-1617.10-1616.90-1633.20

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for TADA2B

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.15567973446733e-840.8411721490176782.12967146524318e-510.7229921688652293.22976482122157e-200.491032619354001
AC7.08904477362349e-1210.9434105253134691.01478496054392e-740.8608458100032011.51838821989419e-120.427780877771198
PCC3.93588631289894e-660.8893023809036661.30682209746174e-620.8787213945523523.09246823812351e-050.296615120237269
CER8.56252248994798e-560.9018069155240998.69360994267439e-350.8009638102534830.001904131025270990.251521014494082
TCX3.55165329285071e-660.9299214000335854.4947009487311e-240.7074870422193820.00465186905589360.229904488390479
FP7.86831222678436e-410.7996054854934693.63522575971091e-190.6051968206813322.01134943167111e-100.453724271742648
IFG1.91840139979279e-060.7963698379451764.51663707802079e-070.8225731478969590.2168474991187130.255955068805226
PG1.01718103419686e-300.7175652077766331.22023950921596e-230.6492176754236980.004319072369158920.20835862295127
STG3.16315523316193e-260.8645626066871152.3799346903607e-130.6944224633976150.1231406491077440.169535962427028

Top

Relation with AD stages for TADA2B

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.001051001452448610.311042355768688
TCX4.9659817473483e-050.38344607883893

Top

RelatedDrugs for TADA2B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TADA2B

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource