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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for FBXO44 |
 Gene summary |
| Gene information | Gene symbol | FBXO44 | Gene ID | 93611 |
| Gene name | F-box protein 44 | |
| Synonyms | FBG3|FBX30|FBX6A|Fbx44|Fbxo6a | |
| Cytomap | 1p36.22 | |
| Type of gene | protein-coding | |
| Description | F-box only protein 44F-box gene 3F-box protein FBX30F-box/G-domain protein 3 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9H4M3, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FBXO44 | GO:0010498 | proteasomal protein catabolic process | 25970626 |
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RNA A-to-I events for FBXO44 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_10450(11656375, +), ADediting_10451(11656437, +), ADediting_10452(11657478, +), ADediting_10453(11657620, +), ADediting_10454(11657621, +), ADediting_10455(11659116, +), ADediting_10456(11659124, +), ADediting_10457(11659126, +), ADediting_10458(11659133, +), ADediting_10459(11659159, +), ADediting_10460(11659192, +), ADediting_10461(11659201, +), ADediting_10462(11659202, +), ADediting_10463(11659211, +), ADediting_10464(11659212, +), ADediting_10465(11659223, +), ADediting_10466(11659226, +), ADediting_10467(11659227, +), ADediting_10468(11659228, +), ADediting_10469(11659229, +), ADediting_10470(11659230, +), ADediting_10471(11659232, +), ADediting_10472(11659235, +), ADediting_10473(11659236, +), ADediting_10474(11659237, +), ADediting_10475(11659240, +), ADediting_10476(11659256, +), ADediting_10477(11659267, +), ADediting_10478(11659280, +), ADediting_10479(11659303, +), ADediting_10480(11659328, +), ADediting_10481(11659343, +), ADediting_10482(11659357, +), ADediting_10483(11659589, +), ADediting_10484(11659679, +), ADediting_10485(11659757, +), ADediting_10486(11659758, +), ADediting_10487(11659776, +), ADediting_10488(11660232, +), ADediting_10489(11660261, +), ADediting_10490(11660262, +), ADediting_10491(11660263, +), ADediting_10492(11660334, +), ADediting_10493(11660369, +), ADediting_10494(11660422, +), ADediting_10495(11660440, +), ADediting_10496(11660855, +), ADediting_10497(11660960, +), ADediting_10498(11660997, +), ADediting_10499(11661019, +), ADediting_10500(11661048, +), ADediting_1514098(11657468, +), ADediting_1514099(11657484, +), |
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RNA editing positional annotations for FBXO44 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_10450 | chr1_11656375_+ | intronic |
| ADediting_10451 | chr1_11656437_+ | intronic |
| ADediting_10452 | chr1_11657478_+ | intronic |
| ADediting_10453 | chr1_11657620_+ | intronic |
| ADediting_10454 | chr1_11657621_+ | intronic |
| ADediting_10455 | chr1_11659116_+ | intronic |
| ADediting_10456 | chr1_11659124_+ | intronic |
| ADediting_10457 | chr1_11659126_+ | intronic |
| ADediting_10458 | chr1_11659133_+ | intronic |
| ADediting_10459 | chr1_11659159_+ | intronic |
| ADediting_10460 | chr1_11659192_+ | intronic |
| ADediting_10461 | chr1_11659201_+ | intronic |
| ADediting_10462 | chr1_11659202_+ | intronic |
| ADediting_10463 | chr1_11659211_+ | intronic |
| ADediting_10464 | chr1_11659212_+ | intronic |
| ADediting_10465 | chr1_11659223_+ | intronic |
| ADediting_10466 | chr1_11659226_+ | intronic |
| ADediting_10467 | chr1_11659227_+ | intronic |
| ADediting_10468 | chr1_11659228_+ | intronic |
| ADediting_10469 | chr1_11659229_+ | intronic |
| ADediting_10470 | chr1_11659230_+ | intronic |
| ADediting_10471 | chr1_11659232_+ | intronic |
| ADediting_10472 | chr1_11659235_+ | intronic |
| ADediting_10473 | chr1_11659236_+ | intronic |
| ADediting_10474 | chr1_11659237_+ | intronic |
| ADediting_10475 | chr1_11659240_+ | intronic |
| ADediting_10476 | chr1_11659256_+ | intronic |
| ADediting_10477 | chr1_11659267_+ | intronic |
| ADediting_10478 | chr1_11659280_+ | intronic |
| ADediting_10479 | chr1_11659303_+ | intronic |
| ADediting_10480 | chr1_11659328_+ | intronic |
| ADediting_10481 | chr1_11659343_+ | intronic |
| ADediting_10482 | chr1_11659357_+ | intronic |
| ADediting_10483 | chr1_11659589_+ | intronic |
| ADediting_10484 | chr1_11659679_+ | intronic |
| ADediting_10485 | chr1_11659757_+ | intronic |
| ADediting_10486 | chr1_11659758_+ | intronic |
| ADediting_10487 | chr1_11659776_+ | intronic |
| ADediting_10488 | chr1_11660232_+ | intronic |
| ADediting_10489 | chr1_11660261_+ | intronic |
| ADediting_10490 | chr1_11660262_+ | intronic |
| ADediting_10491 | chr1_11660263_+ | intronic |
| ADediting_10492 | chr1_11660334_+ | intronic |
| ADediting_10493 | chr1_11660369_+ | intronic |
| ADediting_10494 | chr1_11660422_+ | intronic |
| ADediting_10495 | chr1_11660440_+ | intronic |
| ADediting_10496 | chr1_11660855_+ | intronic |
| ADediting_10497 | chr1_11660960_+ | intronic |
| ADediting_10498 | chr1_11660997_+ | intronic |
| ADediting_10499 | chr1_11661019_+ | intronic |
| ADediting_10500 | chr1_11661048_+ | intronic |
| ADediting_1514098 | chr1_11657468_+ | intronic |
| ADediting_1514099 | chr1_11657484_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_10450 | chr1_11656375_+ | SINE | Alu | Name=AluSx |
| ADediting_10451 | chr1_11656437_+ | SINE | Alu | Name=AluSx |
| ADediting_10452 | chr1_11657478_+ | SINE | Alu | Name=AluSq2 |
| ADediting_10453 | chr1_11657620_+ | SINE | Alu | Name=AluSq2 |
| ADediting_10454 | chr1_11657621_+ | SINE | Alu | Name=AluSq2 |
| ADediting_10455 | chr1_11659116_+ | SINE | Alu | Name=AluSp |
| ADediting_10456 | chr1_11659124_+ | SINE | Alu | Name=AluSp |
| ADediting_10457 | chr1_11659126_+ | SINE | Alu | Name=AluSp |
| ADediting_10458 | chr1_11659133_+ | SINE | Alu | Name=AluSp |
| ADediting_10459 | chr1_11659159_+ | SINE | Alu | Name=AluSp |
| ADediting_10460 | chr1_11659192_+ | SINE | Alu | Name=AluSp |
| ADediting_10461 | chr1_11659201_+ | SINE | Alu | Name=AluSp |
| ADediting_10462 | chr1_11659202_+ | SINE | Alu | Name=AluSp |
| ADediting_10463 | chr1_11659211_+ | SINE | Alu | Name=AluSp |
| ADediting_10464 | chr1_11659212_+ | SINE | Alu | Name=AluSp |
| ADediting_10465 | chr1_11659223_+ | SINE | Alu | Name=AluSp |
| ADediting_10466 | chr1_11659226_+ | SINE | Alu | Name=AluSp |
| ADediting_10467 | chr1_11659227_+ | SINE | Alu | Name=AluSp |
| ADediting_10468 | chr1_11659228_+ | SINE | Alu | Name=AluSp |
| ADediting_10469 | chr1_11659229_+ | SINE | Alu | Name=AluSp |
| ADediting_10470 | chr1_11659230_+ | SINE | Alu | Name=AluSp |
| ADediting_10471 | chr1_11659232_+ | SINE | Alu | Name=AluSp |
| ADediting_10472 | chr1_11659235_+ | SINE | Alu | Name=AluSp |
| ADediting_10473 | chr1_11659236_+ | SINE | Alu | Name=AluSp |
| ADediting_10474 | chr1_11659237_+ | SINE | Alu | Name=AluSp |
| ADediting_10475 | chr1_11659240_+ | SINE | Alu | Name=AluSp |
| ADediting_10476 | chr1_11659256_+ | SINE | Alu | Name=AluSp |
| ADediting_10477 | chr1_11659267_+ | SINE | Alu | Name=AluSp |
| ADediting_10478 | chr1_11659280_+ | SINE | Alu | Name=AluSp |
| ADediting_10479 | chr1_11659303_+ | SINE | Alu | Name=AluSp |
| ADediting_10480 | chr1_11659328_+ | SINE | Alu | Name=AluSp |
| ADediting_10481 | chr1_11659343_+ | SINE | Alu | Name=AluSp |
| ADediting_10482 | chr1_11659357_+ | SINE | Alu | Name=AluSp |
| ADediting_10483 | chr1_11659589_+ | SINE | Alu | Name=AluJr |
| ADediting_10484 | chr1_11659679_+ | SINE | Alu | Name=AluJr |
| ADediting_10485 | chr1_11659757_+ | SINE | Alu | Name=AluJr |
| ADediting_10486 | chr1_11659758_+ | SINE | Alu | Name=AluJr |
| ADediting_10487 | chr1_11659776_+ | SINE | Alu | Name=AluJr |
| ADediting_10488 | chr1_11660232_+ | SINE | Alu | Name=AluSx |
| ADediting_10489 | chr1_11660261_+ | SINE | Alu | Name=AluSx |
| ADediting_10490 | chr1_11660262_+ | SINE | Alu | Name=AluSx |
| ADediting_10491 | chr1_11660263_+ | SINE | Alu | Name=AluSx |
| ADediting_10492 | chr1_11660334_+ | SINE | Alu | Name=AluSx |
| ADediting_10493 | chr1_11660369_+ | SINE | Alu | Name=AluSx |
| ADediting_10494 | chr1_11660422_+ | SINE | Alu | Name=AluSx |
| ADediting_10495 | chr1_11660440_+ | SINE | Alu | Name=AluSx |
| ADediting_10496 | chr1_11660855_+ | SINE | Alu | Name=AluJo |
| ADediting_10497 | chr1_11660960_+ | SINE | Alu | Name=AluJo |
| ADediting_10498 | chr1_11660997_+ | SINE | Alu | Name=AluJo |
| ADediting_10499 | chr1_11661019_+ | SINE | Alu | Name=AluJo |
| ADediting_10500 | chr1_11661048_+ | SINE | Alu | Name=AluJo |
| ADediting_1514098 | chr1_11657468_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1514099 | chr1_11657484_+ | SINE | Alu | Name=AluSq2 |
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RNA A-to-I editing events in the alternative splicing sites for FBXO44 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| A3SS | ADediting_10484 | chr1_11659679_+ | 11659661:11659683 | 3ss | 2i | AAAAAAATTTTTTTTTGTAGAGA | 6.47 | AAAAAAATTTTTTTTTGTGGAGA | -1.49 |
| ES | ADediting_10466 | chr1_11659226_+ | 11659226:11659248 | 3ss | 20i | AAAAATACAAAATTACCCAGGCG | 0.91 | GAAAATACAAAATTACCCAGGCG | 0.52 |
| ES | ADediting_10467 | chr1_11659227_+ | 11659226:11659248 | 3ss | 19i | AAAAATACAAAATTACCCAGGCG | 0.91 | AGAAATACAAAATTACCCAGGCG | -0.41 |
| ES | ADediting_10468 | chr1_11659228_+ | 11659226:11659248 | 3ss | 18i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAGAATACAAAATTACCCAGGCG | -0.10 |
| ES | ADediting_10469 | chr1_11659229_+ | 11659226:11659248 | 3ss | 17i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAGATACAAAATTACCCAGGCG | -0.34 |
| ES | ADediting_10470 | chr1_11659230_+ | 11659226:11659248 | 3ss | 16i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAGTACAAAATTACCCAGGCG | -0.53 |
| ES | ADediting_10471 | chr1_11659232_+ | 11659226:11659248 | 3ss | 14i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATGCAAAATTACCCAGGCG | 1.39 |
| ES | ADediting_10472 | chr1_11659235_+ | 11659226:11659248 | 3ss | 11i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAGAATTACCCAGGCG | -4.03 |
| ES | ADediting_10473 | chr1_11659236_+ | 11659226:11659248 | 3ss | 10i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAAGATTACCCAGGCG | -4.55 |
| ES | ADediting_10474 | chr1_11659237_+ | 11659226:11659248 | 3ss | 9i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAAAGTTACCCAGGCG | -5.34 |
| ES | ADediting_10475 | chr1_11659240_+ | 11659226:11659248 | 3ss | 6i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAAAATTGCCCAGGCG | 0.77 |
| ME1 | ADediting_10467 | chr1_11659227_+ | 11659226:11659248 | 3ss | 19i | AAAAATACAAAATTACCCAGGCG | 0.91 | AGAAATACAAAATTACCCAGGCG | -0.41 |
| ME1 | ADediting_10467 | chr1_11659227_+ | 11659226:11659248 | 3ss | 19i | AAAAATACAAAATTACCCAGGCG | 0.91 | AGAAATACAAAATTACCCAGGCG | -0.41 |
| ME1 | ADediting_10469 | chr1_11659229_+ | 11659226:11659248 | 3ss | 17i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAGATACAAAATTACCCAGGCG | -0.34 |
| ME1 | ADediting_10469 | chr1_11659229_+ | 11659226:11659248 | 3ss | 17i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAGATACAAAATTACCCAGGCG | -0.34 |
| ME1 | ADediting_10470 | chr1_11659230_+ | 11659226:11659248 | 3ss | 16i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAGTACAAAATTACCCAGGCG | -0.53 |
| ME1 | ADediting_10470 | chr1_11659230_+ | 11659226:11659248 | 3ss | 16i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAGTACAAAATTACCCAGGCG | -0.53 |
| ME1 | ADediting_10471 | chr1_11659232_+ | 11659226:11659248 | 3ss | 14i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATGCAAAATTACCCAGGCG | 1.39 |
| ME1 | ADediting_10471 | chr1_11659232_+ | 11659226:11659248 | 3ss | 14i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATGCAAAATTACCCAGGCG | 1.39 |
| ME1 | ADediting_10472 | chr1_11659235_+ | 11659226:11659248 | 3ss | 11i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAGAATTACCCAGGCG | -4.03 |
| ME1 | ADediting_10472 | chr1_11659235_+ | 11659226:11659248 | 3ss | 11i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAGAATTACCCAGGCG | -4.03 |
| ME1 | ADediting_10473 | chr1_11659236_+ | 11659226:11659248 | 3ss | 10i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAAGATTACCCAGGCG | -4.55 |
| ME1 | ADediting_10473 | chr1_11659236_+ | 11659226:11659248 | 3ss | 10i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAAGATTACCCAGGCG | -4.55 |
| ME1 | ADediting_10474 | chr1_11659237_+ | 11659226:11659248 | 3ss | 9i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAAAGTTACCCAGGCG | -5.34 |
| ME1 | ADediting_10474 | chr1_11659237_+ | 11659226:11659248 | 3ss | 9i | AAAAATACAAAATTACCCAGGCG | 0.91 | AAAAATACAAAGTTACCCAGGCG | -5.34 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FBXO44 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for FBXO44 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for FBXO44 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000251546.8 | FBXO44-201 | hsa-miR-589-3p | chr1 | 11661766 | 11661772 | 7mer-m8 | 11661749 | 11661773 | 149 | -23.76 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000251546.8 | FBXO44-201 | hsa-miR-589-3p | chr1 | 11662023 | 11662030 | 8mer-1a | 11662007 | 11662030 | 159 | -23.85 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000251547.10 | FBXO44-202 | hsa-miR-589-3p | chr1 | 11661766 | 11661772 | 7mer-m8 | 11661749 | 11661773 | 149 | -23.76 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000251547.10 | FBXO44-202 | hsa-miR-589-3p | chr1 | 11662023 | 11662030 | 8mer-1a | 11662007 | 11662030 | 159 | -23.85 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000376762.8 | FBXO44-204 | hsa-miR-589-3p | chr1 | 11661766 | 11661772 | 7mer-m8 | 11661749 | 11661773 | 149 | -23.76 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000376762.8 | FBXO44-204 | hsa-miR-589-3p | chr1 | 11662023 | 11662030 | 8mer-1a | 11662007 | 11662030 | 159 | -23.85 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000376770.5 | FBXO44-206 | hsa-miR-589-3p | chr1 | 11661766 | 11661772 | 7mer-m8 | 11661749 | 11661773 | 149 | -23.76 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000132879.14 | ENST00000376770.5 | FBXO44-206 | hsa-miR-589-3p | chr1 | 11662023 | 11662030 | 8mer-1a | 11662007 | 11662030 | 159 | -23.85 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000132879.14 | ENST00000251546.8 | FBXO44-201 | hsa-miR-589-5p | chr1 | 11661955 | 11661962 | 8mer-1a | 11661941 | 11661962 | 152 | -23.01 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000132879.14 | ENST00000251547.10 | FBXO44-202 | hsa-miR-589-5p | chr1 | 11661955 | 11661962 | 8mer-1a | 11661941 | 11661962 | 152 | -23.01 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000132879.14 | ENST00000376762.8 | FBXO44-204 | hsa-miR-589-5p | chr1 | 11661955 | 11661962 | 8mer-1a | 11661941 | 11661962 | 152 | -23.01 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000132879.14 | ENST00000376770.5 | FBXO44-206 | hsa-miR-589-5p | chr1 | 11661955 | 11661962 | 8mer-1a | 11661941 | 11661962 | 152 | -23.01 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000132879.14 | ENST00000251546.8 | FBXO44-201 | hsa-miR-337-3p | chr1 | 11661982 | 11661988 | 7mer-m8 | 11661966 | 11661989 | 157 | -16.22 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000132879.14 | ENST00000251547.10 | FBXO44-202 | hsa-miR-337-3p | chr1 | 11661982 | 11661988 | 7mer-m8 | 11661966 | 11661989 | 157 | -16.22 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000132879.14 | ENST00000376762.8 | FBXO44-204 | hsa-miR-337-3p | chr1 | 11661982 | 11661988 | 7mer-m8 | 11661966 | 11661989 | 157 | -16.22 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000132879.14 | ENST00000376770.5 | FBXO44-206 | hsa-miR-337-3p | chr1 | 11661982 | 11661988 | 7mer-m8 | 11661966 | 11661989 | 157 | -16.22 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000132879.14 | ENST00000251547.10 | FBXO44-202 | hsa-miR-5585-3p | chr1 | 11663058 | 11663064 | 7mer-m8 | 11663044 | 11663065 | 156 | -18.5 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000132879.14 | ENST00000376770.5 | FBXO44-206 | hsa-miR-5585-3p | chr1 | 11663058 | 11663064 | 7mer-m8 | 11663044 | 11663065 | 156 | -18.5 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000132879.14 | ENST00000475435.5 | FBXO44-209 | hsa-miR-5585-3p | chr1 | 11663058 | 11663064 | 7mer-m8 | 11663044 | 11663065 | 156 | -18.5 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000132879.14 | ENST00000251547.10 | FBXO44-202 | hsa-miR-151a-3p | chr1 | 11662283 | 11662290 | 8mer-1a | 11662269 | 11662290 | 148 | -15.46 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000132879.14 | ENST00000376762.8 | FBXO44-204 | hsa-miR-151a-3p | chr1 | 11662283 | 11662290 | 8mer-1a | 11662269 | 11662290 | 148 | -15.46 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000132879.14 | ENST00000376770.5 | FBXO44-206 | hsa-miR-151a-3p | chr1 | 11662283 | 11662290 | 8mer-1a | 11662269 | 11662290 | 148 | -15.46 |
| ADediting_291761 | chr11_93733708_- | ENSG00000132879.14 | ENST00000251547.10 | FBXO44-202 | hsa-miR-1304-3p | chr1 | 11662446 | 11662452 | 7mer-m8 | 11662432 | 11662453 | 144 | -17.75 |
| ADediting_291761 | chr11_93733708_- | ENSG00000132879.14 | ENST00000376770.5 | FBXO44-206 | hsa-miR-1304-3p | chr1 | 11662446 | 11662452 | 7mer-m8 | 11662432 | 11662453 | 144 | -17.75 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for FBXO44 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for FBXO44 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_10460 | chr1_11659192_+ | 9.34701989542849e-05 | 0.313541587073648 | 1.04781740332778e-07 | 0.417707761165091 | 0.100361673581256 | 0.134673487174554 |
| CER | ADediting_10464 | chr1_11659212_+ | 0.000179459727062572 | 0.301266722796804 | 1.66167140748357e-09 | 0.467255196687747 | 0.0763279593655189 | 0.145162778299622 |
| CER | ADediting_10467 | chr1_11659227_+ | 0.00374219106537708 | 0.235346237740563 | 8.47171866679764e-06 | 0.354655181423955 | 0.147119510338776 | 0.118948522735124 |
| CER | ADediting_10479 | chr1_11659303_+ | 0.0215177118750633 | 0.187593992479044 | 8.41584957982942e-05 | 0.31546716023561 | 0.432409848641666 | 0.0645743245841768 |
| CER | ADediting_10483 | chr1_11659589_+ | 3.99884041703468e-05 | 0.328759082083748 | 1.98816885729975e-08 | 0.438540360303729 | 0.00474007172812228 | 0.229429025393977 |
| CER | ADediting_10488 | chr1_11660232_+ | 0.000779189076439918 | 0.271450567249327 | 4.68296136357765e-07 | 0.39765328059963 | 0.0104222583306075 | 0.208584442876873 |
| CER | ADediting_10490 | chr1_11660262_+ | 0.00133174631713205 | 0.259680220045351 | 8.00030182754252e-06 | 0.355568173655144 | 0.000223853369069089 | 0.296981401730524 |
| CER | ADediting_10491 | chr1_11660263_+ | 0.0186071797191761 | 0.191962162898241 | 2.33429343171891e-05 | 0.338004786940179 | 0.00447165604627116 | 0.230901603611758 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.01504726809481e-41 | 0.669831693398858 | 1.30817344884969e-69 | 0.797658584696403 | 3.13940247586163e-07 | 0.285586917361758 |
| AC | 2.46522551347248e-77 | 0.867934744229364 | 4.26335608042068e-75 | 0.861891902125093 | 1.15267661018399e-08 | 0.351119090151968 |
| PCC | 2.44864146041195e-42 | 0.791837423064509 | 4.86224212065474e-53 | 0.844056853479225 | 0.127651185226034 | 0.110619082052322 |
| CER | 0.000253981778755542 | 0.294503161839166 | 9.98707738723233e-19 | 0.641010560747732 | 0.0238447284441407 | 0.184454342000332 |
| TCX | 5.40453720964337e-10 | 0.479425537703862 | 1.2756387002644e-28 | 0.752383169902885 | 0.000518082793803357 | -0.280073540384151 |
| FP | 9.4194998084956e-37 | 0.773889518575487 | 4.01319116667519e-20 | 0.617895069543619 | 0.0061868053466542 | 0.204468298269813 |
| IFG | 1.73734730865838e-07 | 0.837843236268199 | 6.5723520187311e-09 | 0.880319798138211 | 0.688891158511521 | 0.0842423605403024 |
| PG | 0.00317821679203472 | 0.215211500729205 | 4.65674898894326e-06 | 0.32863976039014 | 0.464241890749233 | -0.0539888362353999 |
| STG | 1.63016445844337e-23 | 0.840308325902839 | 1.27868563666044e-15 | 0.73726198814493 | 0.603355352110871 | -0.0575056894304679 |
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Relation with AD stages for FBXO44 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| AC | ADediting_10483 | chr1_11659589_+ | 1.16078909608706e-06 | 0.301824511964642 |
| CER | ADediting_10464 | chr1_11659212_+ | 0.000153332958540963 | 0.356381285368752 |
| CER | ADediting_10488 | chr1_11660232_+ | 0.000500511471598568 | 0.329347394758811 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.90871349534844e-06 | 0.439840326067935 |
| PG | 4.07796362795091e-06 | -0.330513908342482 |
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RelatedDrugs for FBXO44 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXO44 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FBXO44 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| FBXO44 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| FBXO44 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| FBXO44 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
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