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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for PCSK7 |
 Gene summary |
| Gene information | Gene symbol | PCSK7 | Gene ID | 9159 |
| Gene name | proprotein convertase subtilisin/kexin type 7 | |
| Synonyms | LPC|PC7|PC8|SPC7 | |
| Cytomap | 11q23.3 | |
| Type of gene | protein-coding | |
| Description | proprotein convertase subtilisin/kexin type 7lymphoma proprotein convertaseprohormone convertase 7prohormone convertase PC7proprotein convertase 7proprotein convertase 8proprotein convertase PC7proprotein convertase subtilisin/kexin type 7 precurso | |
| Modification date | 20200313 | |
| UniProtAcc | Q16549, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PCSK7 | GO:0016485 | protein processing | 15606899 |
Top |
RNA A-to-I events for PCSK7 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_236349(117210416, -), ADediting_236350(117210421, -), ADediting_236351(117210426, -), ADediting_236352(117210444, -), ADediting_236353(117210448, -), ADediting_236354(117210451, -), ADediting_236355(117210455, -), ADediting_236356(117210456, -), ADediting_236357(117210464, -), ADediting_236358(117210465, -), ADediting_236359(117210470, -), ADediting_236360(117210479, -), ADediting_236361(117210487, -), ADediting_236362(117210497, -), ADediting_236363(117210523, -), ADediting_236364(117210526, -), ADediting_236365(117210527, -), ADediting_236366(117210528, -), ADediting_236367(117210541, -), ADediting_236368(117210553, -), ADediting_236369(117210629, -), ADediting_236370(117210630, -), ADediting_236371(117210768, -), ADediting_236372(117210779, -), ADediting_236373(117210786, -), ADediting_236374(117210787, -), ADediting_236375(117210795, -), ADediting_236376(117210803, -), ADediting_236377(117210811, -), ADediting_236378(117210813, -), ADediting_236379(117210823, -), ADediting_236380(117210834, -), ADediting_236381(117210835, -), ADediting_236382(117210841, -), ADediting_236383(117210849, -), ADediting_236384(117210853, -), ADediting_236385(117210854, -), ADediting_236386(117210867, -), ADediting_236387(117210868, -), ADediting_236388(117210874, -), ADediting_236389(117210879, -), ADediting_236390(117210890, -), ADediting_236391(117210892, -), ADediting_236392(117210903, -), ADediting_236393(117210905, -), ADediting_236394(117210910, -), ADediting_236395(117210917, -), ADediting_236396(117210922, -), ADediting_236397(117210930, -), ADediting_236398(117210934, -), ADediting_236399(117211145, -), ADediting_236400(117211196, -), ADediting_236401(117211203, -), ADediting_236402(117211207, -), ADediting_236403(117211208, -), ADediting_236404(117211222, -), ADediting_236405(117211248, -), ADediting_236406(117211249, -), ADediting_236407(117211259, -), ADediting_236408(117211338, -), ADediting_236409(117211357, -), ADediting_236410(117211388, -), ADediting_236411(117212400, -), ADediting_236412(117212405, -), ADediting_236413(117212435, -), ADediting_236414(117212436, -), ADediting_236415(117212441, -), ADediting_236416(117212448, -), ADediting_236417(117212498, -), ADediting_236418(117212502, -), ADediting_236419(117212516, -), ADediting_236420(117212517, -), ADediting_236421(117212550, -), ADediting_236422(117212551, -), ADediting_236423(117212569, -), ADediting_236424(117212595, -), ADediting_236425(117212745, -), ADediting_236426(117212748, -), ADediting_236427(117212749, -), ADediting_236428(117212750, -), ADediting_236429(117212776, -), ADediting_236430(117212803, -), ADediting_236431(117212811, -), ADediting_236432(117212821, -), ADediting_236433(117212829, -), ADediting_236434(117212839, -), ADediting_236435(117212842, -), ADediting_236436(117212879, -), ADediting_236437(117212891, -), ADediting_236438(117212892, -), ADediting_236439(117212893, -), ADediting_236440(117212894, -), ADediting_236441(117212895, -), ADediting_236442(117214053, -), ADediting_236443(117214054, -), ADediting_236444(117214068, -), ADediting_236445(117214095, -), ADediting_236446(117214229, -), ADediting_236447(117214230, -), ADediting_236448(117215218, -), ADediting_236449(117215281, -), ADediting_236450(117215292, -), ADediting_236451(117215334, -), ADediting_236452(117215512, -), ADediting_236453(117215539, -), ADediting_236454(117215854, -), ADediting_236455(117215929, -), ADediting_236456(117215948, -), ADediting_236457(117215953, -), ADediting_236458(117215967, -), ADediting_236459(117216108, -), ADediting_236460(117216542, -), ADediting_236461(117216569, -), ADediting_1525616(117210374, -), ADediting_1525617(117210435, -), ADediting_1525618(117212819, -), ADediting_1525619(117216559, -), |
Top |
RNA editing positional annotations for PCSK7 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_236349 | chr11_117210416_- | intronic |
| ADediting_236350 | chr11_117210421_- | intronic |
| ADediting_236351 | chr11_117210426_- | intronic |
| ADediting_236352 | chr11_117210444_- | intronic |
| ADediting_236353 | chr11_117210448_- | intronic |
| ADediting_236354 | chr11_117210451_- | intronic |
| ADediting_236355 | chr11_117210455_- | intronic |
| ADediting_236356 | chr11_117210456_- | intronic |
| ADediting_236357 | chr11_117210464_- | intronic |
| ADediting_236358 | chr11_117210465_- | intronic |
| ADediting_236359 | chr11_117210470_- | intronic |
| ADediting_236360 | chr11_117210479_- | intronic |
| ADediting_236361 | chr11_117210487_- | intronic |
| ADediting_236362 | chr11_117210497_- | intronic |
| ADediting_236363 | chr11_117210523_- | intronic |
| ADediting_236364 | chr11_117210526_- | intronic |
| ADediting_236365 | chr11_117210527_- | intronic |
| ADediting_236366 | chr11_117210528_- | intronic |
| ADediting_236367 | chr11_117210541_- | intronic |
| ADediting_236368 | chr11_117210553_- | intronic |
| ADediting_236369 | chr11_117210629_- | intronic |
| ADediting_236370 | chr11_117210630_- | intronic |
| ADediting_236371 | chr11_117210768_- | intronic |
| ADediting_236372 | chr11_117210779_- | intronic |
| ADediting_236373 | chr11_117210786_- | intronic |
| ADediting_236374 | chr11_117210787_- | intronic |
| ADediting_236375 | chr11_117210795_- | intronic |
| ADediting_236376 | chr11_117210803_- | intronic |
| ADediting_236377 | chr11_117210811_- | intronic |
| ADediting_236378 | chr11_117210813_- | intronic |
| ADediting_236379 | chr11_117210823_- | intronic |
| ADediting_236380 | chr11_117210834_- | intronic |
| ADediting_236381 | chr11_117210835_- | intronic |
| ADediting_236382 | chr11_117210841_- | intronic |
| ADediting_236383 | chr11_117210849_- | intronic |
| ADediting_236384 | chr11_117210853_- | intronic |
| ADediting_236385 | chr11_117210854_- | intronic |
| ADediting_236386 | chr11_117210867_- | intronic |
| ADediting_236387 | chr11_117210868_- | intronic |
| ADediting_236388 | chr11_117210874_- | intronic |
| ADediting_236389 | chr11_117210879_- | intronic |
| ADediting_236390 | chr11_117210890_- | intronic |
| ADediting_236391 | chr11_117210892_- | intronic |
| ADediting_236392 | chr11_117210903_- | intronic |
| ADediting_236393 | chr11_117210905_- | intronic |
| ADediting_236394 | chr11_117210910_- | intronic |
| ADediting_236395 | chr11_117210917_- | intronic |
| ADediting_236396 | chr11_117210922_- | intronic |
| ADediting_236397 | chr11_117210930_- | intronic |
| ADediting_236398 | chr11_117210934_- | intronic |
| ADediting_236399 | chr11_117211145_- | intronic |
| ADediting_236400 | chr11_117211196_- | intronic |
| ADediting_236401 | chr11_117211203_- | intronic |
| ADediting_236402 | chr11_117211207_- | intronic |
| ADediting_236403 | chr11_117211208_- | intronic |
| ADediting_236404 | chr11_117211222_- | intronic |
| ADediting_236405 | chr11_117211248_- | intronic |
| ADediting_236406 | chr11_117211249_- | intronic |
| ADediting_236407 | chr11_117211259_- | intronic |
| ADediting_236408 | chr11_117211338_- | intronic |
| ADediting_236409 | chr11_117211357_- | intronic |
| ADediting_236410 | chr11_117211388_- | intronic |
| ADediting_236411 | chr11_117212400_- | intronic |
| ADediting_236412 | chr11_117212405_- | intronic |
| ADediting_236413 | chr11_117212435_- | intronic |
| ADediting_236414 | chr11_117212436_- | intronic |
| ADediting_236415 | chr11_117212441_- | intronic |
| ADediting_236416 | chr11_117212448_- | intronic |
| ADediting_236417 | chr11_117212498_- | intronic |
| ADediting_236418 | chr11_117212502_- | intronic |
| ADediting_236419 | chr11_117212516_- | intronic |
| ADediting_236420 | chr11_117212517_- | intronic |
| ADediting_236421 | chr11_117212550_- | intronic |
| ADediting_236422 | chr11_117212551_- | intronic |
| ADediting_236423 | chr11_117212569_- | intronic |
| ADediting_236424 | chr11_117212595_- | intronic |
| ADediting_236425 | chr11_117212745_- | intronic |
| ADediting_236426 | chr11_117212748_- | intronic |
| ADediting_236427 | chr11_117212749_- | intronic |
| ADediting_236428 | chr11_117212750_- | intronic |
| ADediting_236429 | chr11_117212776_- | intronic |
| ADediting_236430 | chr11_117212803_- | intronic |
| ADediting_236431 | chr11_117212811_- | intronic |
| ADediting_236432 | chr11_117212821_- | intronic |
| ADediting_236433 | chr11_117212829_- | intronic |
| ADediting_236434 | chr11_117212839_- | intronic |
| ADediting_236435 | chr11_117212842_- | intronic |
| ADediting_236436 | chr11_117212879_- | intronic |
| ADediting_236437 | chr11_117212891_- | intronic |
| ADediting_236438 | chr11_117212892_- | intronic |
| ADediting_236439 | chr11_117212893_- | intronic |
| ADediting_236440 | chr11_117212894_- | intronic |
| ADediting_236441 | chr11_117212895_- | intronic |
| ADediting_236442 | chr11_117214053_- | intronic |
| ADediting_236443 | chr11_117214054_- | intronic |
| ADediting_236444 | chr11_117214068_- | intronic |
| ADediting_236445 | chr11_117214095_- | intronic |
| ADediting_236446 | chr11_117214229_- | intronic |
| ADediting_236447 | chr11_117214230_- | intronic |
| ADediting_236448 | chr11_117215218_- | intronic |
| ADediting_236449 | chr11_117215281_- | intronic |
| ADediting_236450 | chr11_117215292_- | intronic |
| ADediting_236451 | chr11_117215334_- | intronic |
| ADediting_236452 | chr11_117215512_- | intronic |
| ADediting_236453 | chr11_117215539_- | intronic |
| ADediting_236454 | chr11_117215854_- | intronic |
| ADediting_236455 | chr11_117215929_- | intronic |
| ADediting_236456 | chr11_117215948_- | intronic |
| ADediting_236457 | chr11_117215953_- | intronic |
| ADediting_236458 | chr11_117215967_- | intronic |
| ADediting_236459 | chr11_117216108_- | intronic |
| ADediting_236460 | chr11_117216542_- | intronic |
| ADediting_236461 | chr11_117216569_- | intronic |
| ADediting_1525616 | chr11_117210374_- | intronic |
| ADediting_1525617 | chr11_117210435_- | intronic |
| ADediting_1525618 | chr11_117212819_- | intronic |
| ADediting_1525619 | chr11_117216559_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_236349 | chr11_117210416_- | SINE | Alu | Name=AluSc |
| ADediting_236350 | chr11_117210421_- | SINE | Alu | Name=AluSc |
| ADediting_236351 | chr11_117210426_- | SINE | Alu | Name=AluSc |
| ADediting_236352 | chr11_117210444_- | SINE | Alu | Name=AluSc |
| ADediting_236353 | chr11_117210448_- | SINE | Alu | Name=AluSc |
| ADediting_236354 | chr11_117210451_- | SINE | Alu | Name=AluSc |
| ADediting_236355 | chr11_117210455_- | SINE | Alu | Name=AluSc |
| ADediting_236356 | chr11_117210456_- | SINE | Alu | Name=AluSc |
| ADediting_236357 | chr11_117210464_- | SINE | Alu | Name=AluSc |
| ADediting_236358 | chr11_117210465_- | SINE | Alu | Name=AluSc |
| ADediting_236359 | chr11_117210470_- | SINE | Alu | Name=AluSc |
| ADediting_236360 | chr11_117210479_- | SINE | Alu | Name=AluSc |
| ADediting_236361 | chr11_117210487_- | SINE | Alu | Name=AluSc |
| ADediting_236362 | chr11_117210497_- | SINE | Alu | Name=AluSc |
| ADediting_236363 | chr11_117210523_- | SINE | Alu | Name=AluSc |
| ADediting_236364 | chr11_117210526_- | SINE | Alu | Name=AluSc |
| ADediting_236365 | chr11_117210527_- | SINE | Alu | Name=AluSc |
| ADediting_236366 | chr11_117210528_- | SINE | Alu | Name=AluSc |
| ADediting_236367 | chr11_117210541_- | SINE | Alu | Name=AluSc |
| ADediting_236368 | chr11_117210553_- | SINE | Alu | Name=AluSc |
| ADediting_236369 | chr11_117210629_- | SINE | Alu | Name=AluSc |
| ADediting_236370 | chr11_117210630_- | SINE | Alu | Name=AluSc |
| ADediting_236371 | chr11_117210768_- | SINE | Alu | Name=AluSz6 |
| ADediting_236372 | chr11_117210779_- | SINE | Alu | Name=AluSz6 |
| ADediting_236373 | chr11_117210786_- | SINE | Alu | Name=AluSz6 |
| ADediting_236374 | chr11_117210787_- | SINE | Alu | Name=AluSz6 |
| ADediting_236375 | chr11_117210795_- | SINE | Alu | Name=AluSz6 |
| ADediting_236376 | chr11_117210803_- | SINE | Alu | Name=AluSz6 |
| ADediting_236377 | chr11_117210811_- | SINE | Alu | Name=AluSz6 |
| ADediting_236378 | chr11_117210813_- | SINE | Alu | Name=AluSz6 |
| ADediting_236379 | chr11_117210823_- | SINE | Alu | Name=AluSz6 |
| ADediting_236380 | chr11_117210834_- | SINE | Alu | Name=AluSz6 |
| ADediting_236381 | chr11_117210835_- | SINE | Alu | Name=AluSz6 |
| ADediting_236382 | chr11_117210841_- | SINE | Alu | Name=AluSz6 |
| ADediting_236383 | chr11_117210849_- | SINE | Alu | Name=AluSz6 |
| ADediting_236384 | chr11_117210853_- | SINE | Alu | Name=AluSz6 |
| ADediting_236385 | chr11_117210854_- | SINE | Alu | Name=AluSz6 |
| ADediting_236386 | chr11_117210867_- | SINE | Alu | Name=AluSz6 |
| ADediting_236387 | chr11_117210868_- | SINE | Alu | Name=AluSz6 |
| ADediting_236388 | chr11_117210874_- | SINE | Alu | Name=AluSz6 |
| ADediting_236389 | chr11_117210879_- | SINE | Alu | Name=AluSz6 |
| ADediting_236390 | chr11_117210890_- | SINE | Alu | Name=AluSz6 |
| ADediting_236391 | chr11_117210892_- | SINE | Alu | Name=AluSz6 |
| ADediting_236392 | chr11_117210903_- | SINE | Alu | Name=AluSz6 |
| ADediting_236393 | chr11_117210905_- | SINE | Alu | Name=AluSz6 |
| ADediting_236394 | chr11_117210910_- | SINE | Alu | Name=AluSz6 |
| ADediting_236395 | chr11_117210917_- | SINE | Alu | Name=AluSz6 |
| ADediting_236396 | chr11_117210922_- | SINE | Alu | Name=AluSz6 |
| ADediting_236397 | chr11_117210930_- | SINE | Alu | Name=AluSz6 |
| ADediting_236398 | chr11_117210934_- | SINE | Alu | Name=AluSz6 |
| ADediting_236399 | chr11_117211145_- | SINE | Alu | Name=AluSx |
| ADediting_236400 | chr11_117211196_- | SINE | Alu | Name=AluSx |
| ADediting_236401 | chr11_117211203_- | SINE | Alu | Name=AluSx |
| ADediting_236402 | chr11_117211207_- | SINE | Alu | Name=AluSx |
| ADediting_236403 | chr11_117211208_- | SINE | Alu | Name=AluSx |
| ADediting_236404 | chr11_117211222_- | SINE | Alu | Name=AluSx |
| ADediting_236405 | chr11_117211248_- | SINE | Alu | Name=AluSx |
| ADediting_236406 | chr11_117211249_- | SINE | Alu | Name=AluSx |
| ADediting_236407 | chr11_117211259_- | SINE | Alu | Name=AluSx |
| ADediting_236408 | chr11_117211338_- | SINE | Alu | Name=AluSx |
| ADediting_236409 | chr11_117211357_- | SINE | Alu | Name=AluSx |
| ADediting_236410 | chr11_117211388_- | SINE | Alu | Name=AluSx |
| ADediting_236411 | chr11_117212400_- | SINE | Alu | Name=AluSg |
| ADediting_236412 | chr11_117212405_- | SINE | Alu | Name=AluSg |
| ADediting_236413 | chr11_117212435_- | SINE | Alu | Name=AluSg |
| ADediting_236414 | chr11_117212436_- | SINE | Alu | Name=AluSg |
| ADediting_236415 | chr11_117212441_- | SINE | Alu | Name=AluSg |
| ADediting_236416 | chr11_117212448_- | SINE | Alu | Name=AluSg |
| ADediting_236417 | chr11_117212498_- | SINE | Alu | Name=AluSg |
| ADediting_236418 | chr11_117212502_- | SINE | Alu | Name=AluSg |
| ADediting_236419 | chr11_117212516_- | SINE | Alu | Name=AluSg |
| ADediting_236420 | chr11_117212517_- | SINE | Alu | Name=AluSg |
| ADediting_236421 | chr11_117212550_- | SINE | Alu | Name=AluSg |
| ADediting_236422 | chr11_117212551_- | SINE | Alu | Name=AluSg |
| ADediting_236423 | chr11_117212569_- | SINE | Alu | Name=AluSg |
| ADediting_236424 | chr11_117212595_- | SINE | Alu | Name=AluSg |
| ADediting_236425 | chr11_117212745_- | SINE | Alu | Name=AluSz6 |
| ADediting_236426 | chr11_117212748_- | SINE | Alu | Name=AluSz6 |
| ADediting_236427 | chr11_117212749_- | SINE | Alu | Name=AluSz6 |
| ADediting_236428 | chr11_117212750_- | SINE | Alu | Name=AluSz6 |
| ADediting_236429 | chr11_117212776_- | SINE | Alu | Name=AluSz6 |
| ADediting_236430 | chr11_117212803_- | SINE | Alu | Name=AluSz6 |
| ADediting_236431 | chr11_117212811_- | SINE | Alu | Name=AluSz6 |
| ADediting_236432 | chr11_117212821_- | SINE | Alu | Name=AluSz6 |
| ADediting_236433 | chr11_117212829_- | SINE | Alu | Name=AluSz6 |
| ADediting_236434 | chr11_117212839_- | SINE | Alu | Name=AluSz6 |
| ADediting_236435 | chr11_117212842_- | SINE | Alu | Name=AluSz6 |
| ADediting_236436 | chr11_117212879_- | SINE | Alu | Name=AluSz6 |
| ADediting_236437 | chr11_117212891_- | SINE | Alu | Name=AluSz6 |
| ADediting_236438 | chr11_117212892_- | SINE | Alu | Name=AluSz6 |
| ADediting_236439 | chr11_117212893_- | SINE | Alu | Name=AluSz6 |
| ADediting_236440 | chr11_117212894_- | SINE | Alu | Name=AluSz6 |
| ADediting_236441 | chr11_117212895_- | SINE | Alu | Name=AluSz6 |
| ADediting_236442 | chr11_117214053_- | SINE | Alu | Name=AluSc |
| ADediting_236443 | chr11_117214054_- | SINE | Alu | Name=AluSc |
| ADediting_236444 | chr11_117214068_- | SINE | Alu | Name=AluSc |
| ADediting_236445 | chr11_117214095_- | SINE | Alu | Name=AluSc |
| ADediting_236446 | chr11_117214229_- | SINE | Alu | Name=AluSc |
| ADediting_236447 | chr11_117214230_- | SINE | Alu | Name=AluSc |
| ADediting_236448 | chr11_117215218_- | SINE | Alu | Name=AluSz |
| ADediting_236449 | chr11_117215281_- | SINE | Alu | Name=AluSz |
| ADediting_236450 | chr11_117215292_- | SINE | Alu | Name=AluSz |
| ADediting_236451 | chr11_117215334_- | SINE | Alu | Name=AluSz |
| ADediting_236452 | chr11_117215512_- | SINE | Alu | Name=AluY |
| ADediting_236453 | chr11_117215539_- | SINE | Alu | Name=AluY |
| ADediting_236454 | chr11_117215854_- | SINE | Alu | Name=AluSz |
| ADediting_236455 | chr11_117215929_- | SINE | Alu | Name=AluJo |
| ADediting_236456 | chr11_117215948_- | SINE | Alu | Name=AluJo |
| ADediting_236457 | chr11_117215953_- | SINE | Alu | Name=AluJo |
| ADediting_236458 | chr11_117215967_- | SINE | Alu | Name=AluJo |
| ADediting_236459 | chr11_117216108_- | SINE | Alu | Name=AluJo |
| ADediting_236460 | chr11_117216542_- | SINE | Alu | Name=AluSq2 |
| ADediting_236461 | chr11_117216569_- | SINE | Alu | Name=AluSq2 |
| ADediting_1525616 | chr11_117210374_- | SINE | Alu | Name=AluSc |
| ADediting_1525617 | chr11_117210435_- | SINE | Alu | Name=AluSc |
| ADediting_1525618 | chr11_117212819_- | SINE | Alu | Name=AluSz6 |
| ADediting_1525619 | chr11_117216559_- | SINE | Alu | Name=AluSq2 |
Top |
RNA A-to-I editing events in the alternative splicing sites for PCSK7 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for PCSK7 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for PCSK7 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for PCSK7 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_843620 | chr2_207754818_+ | ENSG00000160613.13 | ENST00000320934.8 | PCSK7-201 | hsa-miR-4775 | chr11 | 117205951 | 117205957 | 7mer-m8 | 117205950 | 117205971 | 140 | -4.98 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000160613.13 | ENST00000540028.5 | PCSK7-215 | hsa-miR-4775 | chr11 | 117205951 | 117205957 | 7mer-m8 | 117205950 | 117205971 | 140 | -4.98 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for PCSK7 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for PCSK7 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_236351 | chr11_117210426_- | 0.0252507617058447 | 0.182682747571974 | 0.000148767086624168 | 0.304851891190154 | 0.470401568320856 | 0.0593815501029669 |
| CER | ADediting_236354 | chr11_117210451_- | 0.000996465183531552 | 0.266114916483457 | 6.09814546610651e-07 | 0.393975935864996 | 0.0470350254420238 | 0.162435240358467 |
| CER | ADediting_236355 | chr11_117210455_- | 0.00124250979617072 | 0.261233541789747 | 1.48018017594311e-05 | 0.34560557759272 | 0.139551310192347 | 0.121203152027775 |
| CER | ADediting_236359 | chr11_117210470_- | 0.000960693022028333 | 0.266914885004304 | 3.68693116039611e-05 | 0.330173043637213 | 0.0892386432950958 | 0.139245711703983 |
| TCX | ADediting_236359 | chr11_117210470_- | 0.304739784329907 | 0.0843550521696962 | 0.559894805643619 | -0.0479754825509128 | 1.44529994925268e-05 | 0.34599806991497 |
| CER | ADediting_236360 | chr11_117210479_- | 0.000699321971803371 | 0.273762811267302 | 6.5276412153732e-05 | 0.320075622208968 | 0.290114778976075 | 0.0869383301481615 |
| TCX | ADediting_236360 | chr11_117210479_- | 0.0294499016713306 | 0.1778528047636 | 0.466072622413806 | -0.0599611555085872 | 1.95243235361912e-09 | 0.465468112534663 |
| CER | ADediting_236361 | chr11_117210487_- | 0.00367001566498238 | 0.235827456810108 | 1.16735316009012e-06 | 0.384739185126637 | 0.708333074924345 | 0.0307951597633763 |
| CER | ADediting_236362 | chr11_117210497_- | 1.6147064178696e-07 | 0.412048747762088 | 1.01681028424757e-07 | 0.418097014856727 | 0.521094946416667 | 0.0527963040014605 |
| TCX | ADediting_236362 | chr11_117210497_- | 0.0649527117430005 | 0.151088916275982 | 0.588801677317648 | 0.0444879305594755 | 1.31466307201777e-06 | 0.38301779520633 |
| CER | ADediting_236363 | chr11_117210523_- | 0.000111299118629789 | 0.310308790423994 | 4.74067932072546e-06 | 0.363785071461953 | 0.313652524799713 | 0.0828205723141032 |
| CER | ADediting_236376 | chr11_117210803_- | 0.00441017282533961 | 0.23125004491165 | 0.000131638014973525 | 0.307165403900249 | 0.0823794329188234 | 0.142296773092313 |
| CER | ADediting_236378 | chr11_117210813_- | 4.62429942172183e-07 | 0.39782773084411 | 1.26123117418004e-07 | 0.415294601703505 | 0.00619866222418324 | 0.222534085663849 |
| CER | ADediting_236380 | chr11_117210834_- | 4.96269800889836e-06 | 0.363075398234991 | 4.3675821097037e-07 | 0.398616896507001 | 0.295678537428852 | 0.0859456356390715 |
| TCX | ADediting_236380 | chr11_117210834_- | 0.119408319684763 | 0.127697025722169 | 0.766536854886283 | -0.0244432818144845 | 2.60375645663291e-05 | 0.336152131859403 |
| DLPFC | ADediting_236382 | chr11_117210841_- | 3.26792337631553e-07 | 0.285181471856818 | 1.89101232233088e-11 | 0.369270494818149 | 0.0273359947481458 | 0.125343031221768 |
| CER | ADediting_236382 | chr11_117210841_- | 8.68763715570357e-05 | 0.314885331556 | 3.8227907849755e-07 | 0.400449838059358 | 0.0428055273478357 | 0.165631175258887 |
| CER | ADediting_236384 | chr11_117210853_- | 0.00233312164730227 | 0.246765414755958 | 0.000117976281245994 | 0.309221581089622 | 0.858849968280553 | -0.0146421464407519 |
| CER | ADediting_236385 | chr11_117210854_- | 0.00282074997440101 | 0.24224072083097 | 4.72457512929141e-05 | 0.325833363567662 | 0.071953449277057 | 0.147351018231854 |
| CER | ADediting_236386 | chr11_117210867_- | 0.000222209071048733 | 0.297125410390424 | 5.3896470405201e-06 | 0.361791431833057 | 0.184821977644859 | 0.108860417663298 |
| CER | ADediting_236388 | chr11_117210874_- | 0.000247403722623294 | 0.295020017881831 | 1.96312395362686e-06 | 0.37713657668933 | 0.439851969660241 | 0.0635374823908594 |
| TCX | ADediting_236388 | chr11_117210874_- | 0.932136990556465 | -0.0070115670480003 | 0.103362038456748 | -0.133509194314115 | 9.74422327115259e-05 | 0.312774296936785 |
| CER | ADediting_236390 | chr11_117210890_- | 0.00760075067040582 | 0.217157592598449 | 0.000140229796334256 | 0.305972012900752 | 0.0213697323139296 | 0.18780338125448 |
| TCX | ADediting_236390 | chr11_117210890_- | 0.300449540515245 | 0.085104201508219 | 0.646381066915392 | -0.0377630295137176 | 5.14039141556431e-06 | 0.362528767408989 |
| CER | ADediting_236393 | chr11_117210905_- | 9.32949691716562e-06 | 0.353110788105462 | 1.08707746818165e-05 | 0.350645797103226 | 0.0611755198363056 | 0.153244265867223 |
| TCX | ADediting_236393 | chr11_117210905_- | 0.408114830079153 | 0.0680327008479542 | 0.14389867321051 | -0.119897013057137 | 1.53638462107043e-09 | 0.468120281219466 |
| CER | ADediting_236395 | chr11_117210917_- | 1.9506280221759e-05 | 0.341024409420589 | 2.68946377266059e-06 | 0.372437183826011 | 0.0853869205981532 | 0.140934907956369 |
| TCX | ADediting_236395 | chr11_117210917_- | 0.251769855188248 | 0.094155107469128 | 0.471098754906413 | -0.0592884767457474 | 1.64422424387475e-06 | 0.379750890749464 |
| CER | ADediting_236396 | chr11_117210922_- | 1.22498788951527e-07 | 0.415675412242609 | 2.6043979634359e-09 | 0.46224913041795 | 0.120396587984937 | 0.127359439918222 |
| TCX | ADediting_236396 | chr11_117210922_- | 0.428696636519742 | 0.0650954728443717 | 0.21828100932161 | -0.101107870486366 | 2.06628951420194e-06 | 0.376376989644731 |
| CER | ADediting_236401 | chr11_117211203_- | 0.00399959478119594 | 0.233695417212296 | 2.79242680171672e-05 | 0.334959534993742 | 0.285672870095545 | 0.0877400038723187 |
| CER | ADediting_236402 | chr11_117211207_- | 0.00109267264817722 | 0.264087238782375 | 1.5056898169139e-05 | 0.345324016796549 | 0.901045439976845 | 0.0102377620544594 |
| CER | ADediting_236404 | chr11_117211222_- | 0.00175340215258861 | 0.253426147109094 | 0.000100596924175116 | 0.312185445539066 | 0.0375879426258613 | 0.169960326897003 |
| TCX | ADediting_236422 | chr11_117212551_- | 0.997931743644516 | -0.000213435929486108 | 0.0753389114693382 | -0.145648476791342 | 8.45992406734179e-07 | 0.389354477547883 |
| TCX | ADediting_236425 | chr11_117212745_- | 0.593234526472933 | 0.043960200830373 | 0.241630201554741 | -0.0961881646226481 | 1.15150691693787e-05 | 0.349712146183504 |
| TCX | ADediting_236427 | chr11_117212749_- | 0.733822837462629 | 0.0279932706959648 | 0.504958338944544 | -0.0548543976069401 | 4.50663980914981e-05 | 0.326664882605983 |
| CER | ADediting_236431 | chr11_117212811_- | 8.42438086761703e-07 | 0.389414363729397 | 1.8269952550347e-11 | 0.513475535728853 | 0.0500717252069418 | 0.160285264477053 |
| CER | ADediting_236432 | chr11_117212821_- | 6.35559536374745e-10 | 0.47769827946279 | 4.94977894459371e-12 | 0.525660401986989 | 0.00297259120986512 | 0.240976238562839 |
| TCX | ADediting_236432 | chr11_117212821_- | 0.675223570138864 | 0.034488708708138 | 0.21552332243157 | -0.101713123327664 | 8.71862949168576e-06 | 0.354196000445067 |
| CER | ADediting_236434 | chr11_117212839_- | 0.000830014047418106 | 0.270090084795242 | 4.00858158412259e-05 | 0.328716612646257 | 0.0143359514006768 | 0.199591919701502 |
| CER | ADediting_236436 | chr11_117212879_- | 8.6856761137615e-07 | 0.388979618799638 | 2.34597858332839e-11 | 0.511086454404952 | 0.034426640565851 | 0.172836221067515 |
| CER | ADediting_236439 | chr11_117212893_- | 0.00212230463319759 | 0.248993138382865 | 0.000143232857506419 | 0.305570927210897 | 0.12305452500642 | 0.126462034994028 |
| CER | ADediting_236440 | chr11_117212894_- | 3.12976947821796e-05 | 0.333004660432232 | 8.2348383806235e-07 | 0.389737845012711 | 0.0139492689406914 | 0.200377163408401 |
| TCX | ADediting_236441 | chr11_117212895_- | 0.297610356482305 | 0.0856038579104201 | 0.290800973661008 | -0.0868152176649983 | 7.6230202578585e-05 | 0.317270769360341 |
| CER | ADediting_236452 | chr11_117215512_- | 0.000846027221632071 | 0.26967727759095 | 2.35747620719298e-09 | 0.463365762271723 | 0.00451335479236071 | 0.230667723214533 |
| CER | ADediting_236453 | chr11_117215539_- | 0.00368625064663921 | 0.235718474779014 | 6.42142031747029e-07 | 0.39325134860613 | 0.000497498588795774 | 0.280915142426368 |
| TCX | ADediting_236454 | chr11_117215854_- | 0.0426218196821534 | 0.16577587506343 | 0.969090515919116 | -0.00319052389296583 | 9.31169737981669e-05 | 0.313611288912385 |
| CER | ADediting_236456 | chr11_117215948_- | 0.00282569299443352 | 0.242198598870757 | 8.8781999795214e-08 | 0.419848807266379 | 0.0372831295981152 | 0.170228537172819 |
| TCX | ADediting_236456 | chr11_117215948_- | 0.86360665984827 | -0.01414379397677 | 0.416988196888234 | -0.0667560330122459 | 1.00476623360283e-05 | 0.351917778645586 |
| CER | ADediting_236458 | chr11_117215967_- | 0.00857914900901896 | 0.213906253908832 | 1.09507395051392e-06 | 0.385660974994944 | 0.538254984201958 | 0.0506429944316011 |
| CER | ADediting_236461 | chr11_117216569_- | 0.000133137522745747 | 0.306951987824013 | 4.12649256041515e-06 | 0.365926233328972 | 0.378500952592247 | 0.0724170610816371 |
| TCX | ADediting_236461 | chr11_117216569_- | 0.692011561818838 | 0.0326077850616207 | 0.315525410322576 | -0.082501754044375 | 4.7526779613696e-05 | 0.32572877095349 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 3.91122611490689e-16 | 0.440333512464061 | 9.24200884013001e-13 | 0.390926193376801 | 3.10980440104664e-33 | 0.611922625166396 |
| AC | 4.13206707998128e-31 | 0.647571039092698 | 1.94343860262093e-23 | 0.575381545345641 | 1.02040092677246e-26 | 0.608531398244726 |
| PCC | 2.1307887291323e-20 | 0.604300678928692 | 2.83953804357419e-18 | 0.576001875646082 | 1.32891661929169e-06 | 0.341539302386577 |
| CER | 5.29875413576914e-18 | 0.630546235392713 | 1.49126164585741e-24 | 0.71265843235147 | 0.00640934832546093 | 0.221661071374815 |
| TCX | 5.38619597455999e-13 | 0.545303110943044 | 0.00529162787252626 | 0.226623846181299 | 1.97321318367626e-13 | 0.553793414502916 |
| FP | 7.45606506557615e-19 | 0.600931420126218 | 5.51869347764545e-08 | 0.393496633833398 | 1.8881126255061e-12 | 0.496151388930522 |
| IFG | 7.93184902046351e-05 | 0.706399354003191 | 0.000298275929250074 | 0.663663869896387 | 0.00328232979267307 | 0.564556782482986 |
| PG | 6.01294321126555e-08 | 0.384509009884946 | 1.81185864780676e-08 | 0.398227619021076 | 0.000104926809275175 | 0.280572511712681 |
| STG | 1.21128965024154e-06 | 0.501003128963899 | 0.00965470023485809 | 0.280869327095239 | 0.00126537945551596 | 0.345990060980501 |
Top |
Relation with AD stages for PCSK7 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_236389 | chr11_117210879_- | 0.000372632344631255 | 0.336322009983118 |
| CER | ADediting_236431 | chr11_117212811_- | 0.000136231645811043 | 0.358954624872956 |
| CER | ADediting_236432 | chr11_117212821_- | 1.89697564469202e-05 | 0.398945981827414 |
| CER | ADediting_236436 | chr11_117212879_- | 7.19515199183333e-05 | 0.372482134769816 |
| TCX | ADediting_236393 | chr11_117210905_- | 0.00134502274591751 | 0.307478590872224 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.28919909538814e-05 | 0.388293812713252 |
| TCX | 1.29615031105592e-05 | 0.409667456163046 |
Top |
RelatedDrugs for PCSK7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PCSK7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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