ADeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for SEC11C

check button Gene summary
Gene informationGene symbol

SEC11C

Gene ID

90701

Gene nameSEC11 homolog C, signal peptidase complex subunit
SynonymsSEC11L3|SPC21|SPCS4C
Cytomap

18q21.32

Type of geneprotein-coding
Descriptionsignal peptidase complex catalytic subunit SEC11CSEC11-like 3SEC11-like protein 3SPase 21 kDa subunitmicrosomal signal peptidase 21 kDa subunitsignal peptidase complex 21
Modification date20200313
UniProtAcc

Q9BY50,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

Top

RNA A-to-I events for SEC11C

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_695794(59143097, +), ADediting_695795(59143098, +), ADediting_695796(59143128, +), ADediting_695797(59143152, +), ADediting_695798(59143153, +), ADediting_695799(59143188, +), ADediting_695800(59143191, +), ADediting_695801(59143193, +), ADediting_695802(59143194, +), ADediting_695803(59143197, +), ADediting_695804(59143201, +), ADediting_695805(59143206, +), ADediting_695806(59143226, +), ADediting_695807(59143233, +), ADediting_695808(59143242, +), ADediting_695809(59143259, +), ADediting_695810(59143265, +), ADediting_695811(59143268, +), ADediting_695812(59143278, +), ADediting_695813(59143332, +), ADediting_695814(59143891, +), ADediting_695815(59143915, +), ADediting_695816(59143916, +), ADediting_695817(59143932, +), ADediting_695818(59143951, +), ADediting_695819(59143952, +), ADediting_695820(59143969, +), ADediting_695821(59143981, +), ADediting_695822(59143991, +), ADediting_695823(59143999, +), ADediting_695824(59144034, +), ADediting_695825(59144037, +), ADediting_695826(59144051, +), ADediting_695827(59144054, +), ADediting_695828(59144063, +), ADediting_695829(59144088, +), ADediting_695830(59144101, +), ADediting_695831(59144116, +), ADediting_695832(59144134, +), ADediting_695833(59144475, +), ADediting_695834(59144477, +), ADediting_695835(59144505, +), ADediting_695836(59144510, +), ADediting_695837(59144520, +), ADediting_695838(59144531, +), ADediting_695839(59144539, +), ADediting_695840(59144597, +), ADediting_695841(59144605, +), ADediting_695842(59144650, +), ADediting_695843(59144700, +), ADediting_695844(59153570, +), ADediting_695845(59153572, +), ADediting_695846(59153582, +), ADediting_695847(59153601, +), ADediting_695848(59153607, +), ADediting_695849(59153615, +), ADediting_695850(59153625, +), ADediting_695851(59153630, +), ADediting_695852(59153631, +), ADediting_695853(59153650, +), ADediting_695854(59153651, +), ADediting_695855(59153690, +), ADediting_695856(59153763, +), ADediting_695857(59153768, +), ADediting_695858(59153776, +), ADediting_695859(59153793, +), ADediting_695860(59153806, +), ADediting_695861(59153807, +), ADediting_695862(59153810, +), ADediting_695863(59153824, +), ADediting_695864(59153836, +), ADediting_695865(59153846, +), ADediting_695866(59153852, +), ADediting_695867(59153881, +), ADediting_695868(59153887, +), ADediting_695869(59153890, +), ADediting_695870(59153904, +), ADediting_695871(59153916, +), ADediting_695872(59153922, +), ADediting_695873(59153929, +), ADediting_695874(59153941, +), ADediting_695875(59153969, +), ADediting_695876(59153975, +), ADediting_695877(59153981, +), ADediting_695878(59154810, +), ADediting_695879(59154811, +), ADediting_695880(59154816, +), ADediting_695881(59154832, +), ADediting_695882(59154833, +), ADediting_695883(59154846, +), ADediting_695884(59154856, +), ADediting_695885(59154859, +), ADediting_695886(59154865, +), ADediting_695887(59154870, +), ADediting_695888(59154879, +), ADediting_695889(59154880, +), ADediting_695890(59154888, +), ADediting_695891(59154889, +), ADediting_695892(59154890, +), ADediting_695893(59154901, +), ADediting_695894(59154904, +), ADediting_695895(59154905, +), ADediting_695896(59154906, +), ADediting_695897(59154907, +), ADediting_695898(59154908, +), ADediting_695899(59154910, +), ADediting_695900(59154912, +), ADediting_695901(59154913, +), ADediting_695902(59154914, +), ADediting_695903(59154915, +), ADediting_695904(59154916, +), ADediting_695905(59154945, +), ADediting_695906(59154946, +), ADediting_695907(59154955, +), ADediting_695908(59154967, +), ADediting_695909(59154971, +), ADediting_695910(59154976, +), ADediting_695911(59154977, +), ADediting_695912(59154985, +), ADediting_695913(59154986, +), ADediting_695914(59154993, +), ADediting_695915(59154997, +), ADediting_695916(59154999, +), ADediting_695917(59155006, +), ADediting_695918(59155010, +), ADediting_695919(59155015, +), ADediting_695920(59155022, +), ADediting_695921(59155026, +), ADediting_695922(59155045, +), ADediting_695923(59155047, +), ADediting_695924(59155052, +), ADediting_695925(59155053, +), ADediting_695926(59156053, +), ADediting_695927(59156059, +), ADediting_695928(59156069, +), ADediting_695929(59156076, +), ADediting_695930(59156099, +), ADediting_695931(59156103, +), ADediting_695932(59156112, +), ADediting_695933(59156122, +), ADediting_695934(59156150, +), ADediting_695935(59158195, +), ADediting_695936(59158290, +),

Top

RNA editing positional annotations for SEC11C using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_695794chr18_59143097_+intronic
ADediting_695795chr18_59143098_+intronic
ADediting_695796chr18_59143128_+intronic
ADediting_695797chr18_59143152_+intronic
ADediting_695798chr18_59143153_+intronic
ADediting_695799chr18_59143188_+intronic
ADediting_695800chr18_59143191_+intronic
ADediting_695801chr18_59143193_+intronic
ADediting_695802chr18_59143194_+intronic
ADediting_695803chr18_59143197_+intronic
ADediting_695804chr18_59143201_+intronic
ADediting_695805chr18_59143206_+intronic
ADediting_695806chr18_59143226_+intronic
ADediting_695807chr18_59143233_+intronic
ADediting_695808chr18_59143242_+intronic
ADediting_695809chr18_59143259_+intronic
ADediting_695810chr18_59143265_+intronic
ADediting_695811chr18_59143268_+intronic
ADediting_695812chr18_59143278_+intronic
ADediting_695813chr18_59143332_+intronic
ADediting_695814chr18_59143891_+intronic
ADediting_695815chr18_59143915_+intronic
ADediting_695816chr18_59143916_+intronic
ADediting_695817chr18_59143932_+intronic
ADediting_695818chr18_59143951_+intronic
ADediting_695819chr18_59143952_+intronic
ADediting_695820chr18_59143969_+intronic
ADediting_695821chr18_59143981_+intronic
ADediting_695822chr18_59143991_+intronic
ADediting_695823chr18_59143999_+intronic
ADediting_695824chr18_59144034_+intronic
ADediting_695825chr18_59144037_+intronic
ADediting_695826chr18_59144051_+intronic
ADediting_695827chr18_59144054_+intronic
ADediting_695828chr18_59144063_+intronic
ADediting_695829chr18_59144088_+intronic
ADediting_695830chr18_59144101_+intronic
ADediting_695831chr18_59144116_+intronic
ADediting_695832chr18_59144134_+intronic
ADediting_695833chr18_59144475_+intronic
ADediting_695834chr18_59144477_+intronic
ADediting_695835chr18_59144505_+intronic
ADediting_695836chr18_59144510_+intronic
ADediting_695837chr18_59144520_+intronic
ADediting_695838chr18_59144531_+intronic
ADediting_695839chr18_59144539_+intronic
ADediting_695840chr18_59144597_+intronic
ADediting_695841chr18_59144605_+intronic
ADediting_695842chr18_59144650_+intronic
ADediting_695843chr18_59144700_+intronic
ADediting_695844chr18_59153570_+intronic
ADediting_695845chr18_59153572_+intronic
ADediting_695846chr18_59153582_+intronic
ADediting_695847chr18_59153601_+intronic
ADediting_695848chr18_59153607_+intronic
ADediting_695849chr18_59153615_+intronic
ADediting_695850chr18_59153625_+intronic
ADediting_695851chr18_59153630_+intronic
ADediting_695852chr18_59153631_+intronic
ADediting_695853chr18_59153650_+intronic
ADediting_695854chr18_59153651_+intronic
ADediting_695855chr18_59153690_+intronic
ADediting_695856chr18_59153763_+intronic
ADediting_695857chr18_59153768_+intronic
ADediting_695858chr18_59153776_+intronic
ADediting_695859chr18_59153793_+intronic
ADediting_695860chr18_59153806_+intronic
ADediting_695861chr18_59153807_+intronic
ADediting_695862chr18_59153810_+intronic
ADediting_695863chr18_59153824_+intronic
ADediting_695864chr18_59153836_+intronic
ADediting_695865chr18_59153846_+intronic
ADediting_695866chr18_59153852_+intronic
ADediting_695867chr18_59153881_+intronic
ADediting_695868chr18_59153887_+intronic
ADediting_695869chr18_59153890_+intronic
ADediting_695870chr18_59153904_+intronic
ADediting_695871chr18_59153916_+intronic
ADediting_695872chr18_59153922_+intronic
ADediting_695873chr18_59153929_+intronic
ADediting_695874chr18_59153941_+intronic
ADediting_695875chr18_59153969_+intronic
ADediting_695876chr18_59153975_+intronic
ADediting_695877chr18_59153981_+intronic
ADediting_695878chr18_59154810_+intronic
ADediting_695879chr18_59154811_+intronic
ADediting_695880chr18_59154816_+intronic
ADediting_695881chr18_59154832_+intronic
ADediting_695882chr18_59154833_+intronic
ADediting_695883chr18_59154846_+intronic
ADediting_695884chr18_59154856_+intronic
ADediting_695885chr18_59154859_+intronic
ADediting_695886chr18_59154865_+intronic
ADediting_695887chr18_59154870_+intronic
ADediting_695888chr18_59154879_+intronic
ADediting_695889chr18_59154880_+intronic
ADediting_695890chr18_59154888_+intronic
ADediting_695891chr18_59154889_+intronic
ADediting_695892chr18_59154890_+intronic
ADediting_695893chr18_59154901_+intronic
ADediting_695894chr18_59154904_+intronic
ADediting_695895chr18_59154905_+intronic
ADediting_695896chr18_59154906_+intronic
ADediting_695897chr18_59154907_+intronic
ADediting_695898chr18_59154908_+intronic
ADediting_695899chr18_59154910_+intronic
ADediting_695900chr18_59154912_+intronic
ADediting_695901chr18_59154913_+intronic
ADediting_695902chr18_59154914_+intronic
ADediting_695903chr18_59154915_+intronic
ADediting_695904chr18_59154916_+intronic
ADediting_695905chr18_59154945_+intronic
ADediting_695906chr18_59154946_+intronic
ADediting_695907chr18_59154955_+intronic
ADediting_695908chr18_59154967_+intronic
ADediting_695909chr18_59154971_+intronic
ADediting_695910chr18_59154976_+intronic
ADediting_695911chr18_59154977_+intronic
ADediting_695912chr18_59154985_+intronic
ADediting_695913chr18_59154986_+intronic
ADediting_695914chr18_59154993_+intronic
ADediting_695915chr18_59154997_+intronic
ADediting_695916chr18_59154999_+intronic
ADediting_695917chr18_59155006_+intronic
ADediting_695918chr18_59155010_+intronic
ADediting_695919chr18_59155015_+intronic
ADediting_695920chr18_59155022_+intronic
ADediting_695921chr18_59155026_+intronic
ADediting_695922chr18_59155045_+intronic
ADediting_695923chr18_59155047_+intronic
ADediting_695924chr18_59155052_+intronic
ADediting_695925chr18_59155053_+intronic
ADediting_695926chr18_59156053_+UTR3
ADediting_695927chr18_59156059_+UTR3
ADediting_695928chr18_59156069_+UTR3
ADediting_695929chr18_59156076_+UTR3
ADediting_695930chr18_59156099_+UTR3
ADediting_695931chr18_59156103_+UTR3
ADediting_695932chr18_59156112_+UTR3
ADediting_695933chr18_59156122_+UTR3
ADediting_695934chr18_59156150_+UTR3
ADediting_695935chr18_59158195_+intronic
ADediting_695936chr18_59158290_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_695794chr18_59143097_+SINEAluName=AluSz
ADediting_695795chr18_59143098_+SINEAluName=AluSz
ADediting_695796chr18_59143128_+SINEAluName=AluSz
ADediting_695797chr18_59143152_+SINEAluName=AluSz
ADediting_695798chr18_59143153_+SINEAluName=AluSz
ADediting_695799chr18_59143188_+SINEAluName=AluSz
ADediting_695800chr18_59143191_+SINEAluName=AluSz
ADediting_695801chr18_59143193_+SINEAluName=AluSz
ADediting_695802chr18_59143194_+SINEAluName=AluSz
ADediting_695803chr18_59143197_+SINEAluName=AluSz
ADediting_695804chr18_59143201_+SINEAluName=AluSz
ADediting_695805chr18_59143206_+SINEAluName=AluSz
ADediting_695806chr18_59143226_+SINEAluName=AluSz
ADediting_695807chr18_59143233_+SINEAluName=AluSz
ADediting_695808chr18_59143242_+SINEAluName=AluSz
ADediting_695809chr18_59143259_+SINEAluName=AluSz
ADediting_695810chr18_59143265_+SINEAluName=AluSz
ADediting_695811chr18_59143268_+SINEAluName=AluSz
ADediting_695812chr18_59143278_+SINEAluName=AluSz
ADediting_695813chr18_59143332_+SINEAluName=AluSz
ADediting_695814chr18_59143891_+SINEAluName=AluSx
ADediting_695815chr18_59143915_+SINEAluName=AluSx
ADediting_695816chr18_59143916_+SINEAluName=AluSx
ADediting_695817chr18_59143932_+SINEAluName=AluSx
ADediting_695818chr18_59143951_+SINEAluName=AluSx
ADediting_695819chr18_59143952_+SINEAluName=AluSx
ADediting_695820chr18_59143969_+SINEAluName=AluSx
ADediting_695821chr18_59143981_+SINEAluName=AluSx
ADediting_695822chr18_59143991_+SINEAluName=AluSx
ADediting_695823chr18_59143999_+SINEAluName=AluSx
ADediting_695824chr18_59144034_+SINEAluName=AluSx
ADediting_695825chr18_59144037_+SINEAluName=AluSx
ADediting_695826chr18_59144051_+SINEAluName=AluSx
ADediting_695827chr18_59144054_+SINEAluName=AluSx
ADediting_695828chr18_59144063_+SINEAluName=AluSx
ADediting_695829chr18_59144088_+SINEAluName=AluSx
ADediting_695830chr18_59144101_+SINEAluName=AluSx
ADediting_695831chr18_59144116_+SINEAluName=AluSx
ADediting_695832chr18_59144134_+SINEAluName=AluSx
ADediting_695833chr18_59144475_+SINEAluName=AluJr
ADediting_695834chr18_59144477_+SINEAluName=AluJr
ADediting_695835chr18_59144505_+SINEAluName=AluJr
ADediting_695836chr18_59144510_+SINEAluName=AluJr
ADediting_695837chr18_59144520_+SINEAluName=AluJr
ADediting_695838chr18_59144531_+SINEAluName=AluJr
ADediting_695839chr18_59144539_+SINEAluName=AluJr
ADediting_695840chr18_59144597_+SINEAluName=AluJr
ADediting_695841chr18_59144605_+SINEAluName=AluJr
ADediting_695842chr18_59144650_+SINEAluName=AluJr
ADediting_695843chr18_59144700_+SINEAluName=AluJr
ADediting_695844chr18_59153570_+SINEAluName=AluSx4
ADediting_695845chr18_59153572_+SINEAluName=AluSx4
ADediting_695846chr18_59153582_+SINEAluName=AluSx4
ADediting_695847chr18_59153601_+SINEAluName=AluSx4
ADediting_695848chr18_59153607_+SINEAluName=AluSx4
ADediting_695849chr18_59153615_+SINEAluName=AluSx4
ADediting_695850chr18_59153625_+SINEAluName=AluSx4
ADediting_695851chr18_59153630_+SINEAluName=AluSx4
ADediting_695852chr18_59153631_+SINEAluName=AluSx4
ADediting_695853chr18_59153650_+SINEAluName=AluSx4
ADediting_695854chr18_59153651_+SINEAluName=AluSx4
ADediting_695855chr18_59153690_+SINEAluName=AluSx4
ADediting_695856chr18_59153763_+SINEAluName=AluSx
ADediting_695857chr18_59153768_+SINEAluName=AluSx
ADediting_695858chr18_59153776_+SINEAluName=AluSx
ADediting_695859chr18_59153793_+SINEAluName=AluSx
ADediting_695860chr18_59153806_+SINEAluName=AluSx
ADediting_695861chr18_59153807_+SINEAluName=AluSx
ADediting_695862chr18_59153810_+SINEAluName=AluSx
ADediting_695863chr18_59153824_+SINEAluName=AluSx
ADediting_695864chr18_59153836_+SINEAluName=AluSx
ADediting_695865chr18_59153846_+SINEAluName=AluSx
ADediting_695866chr18_59153852_+SINEAluName=AluSx
ADediting_695867chr18_59153881_+SINEAluName=AluSx
ADediting_695868chr18_59153887_+SINEAluName=AluSx
ADediting_695869chr18_59153890_+SINEAluName=AluSx
ADediting_695870chr18_59153904_+SINEAluName=AluSx
ADediting_695871chr18_59153916_+SINEAluName=AluSx
ADediting_695872chr18_59153922_+SINEAluName=AluSx
ADediting_695873chr18_59153929_+SINEAluName=AluSx
ADediting_695874chr18_59153941_+SINEAluName=AluSx
ADediting_695875chr18_59153969_+SINEAluName=AluSx
ADediting_695876chr18_59153975_+SINEAluName=AluSx
ADediting_695877chr18_59153981_+SINEAluName=AluSx
ADediting_695878chr18_59154810_+SINEAluName=AluSx1
ADediting_695879chr18_59154811_+SINEAluName=AluSx1
ADediting_695880chr18_59154816_+SINEAluName=AluSx1
ADediting_695881chr18_59154832_+SINEAluName=AluSx1
ADediting_695882chr18_59154833_+SINEAluName=AluSx1
ADediting_695883chr18_59154846_+SINEAluName=AluSx1
ADediting_695884chr18_59154856_+SINEAluName=AluSx1
ADediting_695885chr18_59154859_+SINEAluName=AluSx1
ADediting_695886chr18_59154865_+SINEAluName=AluSx1
ADediting_695887chr18_59154870_+SINEAluName=AluSx1
ADediting_695888chr18_59154879_+SINEAluName=AluSx1
ADediting_695889chr18_59154880_+SINEAluName=AluSx1
ADediting_695890chr18_59154888_+SINEAluName=AluSx1
ADediting_695891chr18_59154889_+SINEAluName=AluSx1
ADediting_695892chr18_59154890_+SINEAluName=AluSx1
ADediting_695893chr18_59154901_+SINEAluName=AluSx1
ADediting_695894chr18_59154904_+SINEAluName=AluSx1
ADediting_695895chr18_59154905_+SINEAluName=AluSx1
ADediting_695896chr18_59154906_+SINEAluName=AluSx1
ADediting_695897chr18_59154907_+SINEAluName=AluSx1
ADediting_695898chr18_59154908_+SINEAluName=AluSx1
ADediting_695899chr18_59154910_+SINEAluName=AluSx1
ADediting_695900chr18_59154912_+SINEAluName=AluSx1
ADediting_695901chr18_59154913_+SINEAluName=AluSx1
ADediting_695902chr18_59154914_+SINEAluName=AluSx1
ADediting_695903chr18_59154915_+SINEAluName=AluSx1
ADediting_695904chr18_59154916_+SINEAluName=AluSx1
ADediting_695905chr18_59154945_+SINEAluName=AluSx1
ADediting_695906chr18_59154946_+SINEAluName=AluSx1
ADediting_695907chr18_59154955_+SINEAluName=AluSx1
ADediting_695908chr18_59154967_+SINEAluName=AluSx1
ADediting_695909chr18_59154971_+SINEAluName=AluSx1
ADediting_695910chr18_59154976_+SINEAluName=AluSx1
ADediting_695911chr18_59154977_+SINEAluName=AluSx1
ADediting_695912chr18_59154985_+SINEAluName=AluSx1
ADediting_695913chr18_59154986_+SINEAluName=AluSx1
ADediting_695914chr18_59154993_+SINEAluName=AluSx1
ADediting_695915chr18_59154997_+SINEAluName=AluSx1
ADediting_695916chr18_59154999_+SINEAluName=AluSx1
ADediting_695917chr18_59155006_+SINEAluName=AluSx1
ADediting_695918chr18_59155010_+SINEAluName=AluSx1
ADediting_695919chr18_59155015_+SINEAluName=AluSx1
ADediting_695920chr18_59155022_+SINEAluName=AluSx1
ADediting_695921chr18_59155026_+SINEAluName=AluSx1
ADediting_695922chr18_59155045_+SINEAluName=AluSx1
ADediting_695923chr18_59155047_+SINEAluName=AluSx1
ADediting_695924chr18_59155052_+SINEAluName=AluSx1
ADediting_695925chr18_59155053_+SINEAluName=AluSx1
ADediting_695926chr18_59156053_+SINEAluName=AluJr4
ADediting_695927chr18_59156059_+SINEAluName=AluJr4
ADediting_695928chr18_59156069_+SINEAluName=AluJr4
ADediting_695929chr18_59156076_+SINEAluName=AluJr4
ADediting_695930chr18_59156099_+SINEAluName=AluJr4
ADediting_695931chr18_59156103_+SINEAluName=AluJr4
ADediting_695932chr18_59156112_+SINEAluName=AluJr4
ADediting_695933chr18_59156122_+SINEAluName=AluJr4
ADediting_695934chr18_59156150_+SINEAluName=AluJr4
ADediting_695935chr18_59158195_+SINEAluName=AluSx1
ADediting_695936chr18_59158290_+SINEAluName=AluSx1

Top

RNA A-to-I editing events in the alternative splicing sites for SEC11C

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for SEC11C

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

Top

Protein coding region RNA A-to-I editings for SEC11C

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for SEC11C

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_695930chr18_59156099_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-1913chr1859156097591561037mer-m85915607659156104149-27.28
ADediting_695930chr18_59156099_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-6849-3pchr1859156092591560987mer-m85915607859156099140-16.61
ADediting_695934chr18_59156150_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-4716-5pchr1859156144591561507mer-m85915613059156151142-12.39

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_695926chr18_59156053_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-3064-5pchr1859156047591560537mer-m85915603359156054145-16.78
ADediting_695926chr18_59156053_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-3085-3pchr1859156047591560537mer-m85915603459156054140-14.34
ADediting_695926chr18_59156053_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-6504-5pchr1859156047591560537mer-m85915603559156054147-16.75
ADediting_695926chr18_59156053_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-6720-3pchr1859156051591560588mer-1a5915603659156058150-17.97
ADediting_695926chr18_59156053_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-6842-3pchr1859156046591560527mer-m85915603259156053140-18.04
ADediting_695927chr18_59156059_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-4252chr1859156057591560637mer-m85915604659156064150-18.56
ADediting_695928chr18_59156069_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-552-3pchr1859156067591560748mer-1a5915605459156074140-14.09
ADediting_695929chr18_59156076_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-10399-5pchr1859156070591560767mer-m85915605659156077148-10
ADediting_695929chr18_59156076_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-5089-5pchr1859156074591560807mer-m85915605959156081148-13.62
ADediting_695929chr18_59156076_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-6504-3pchr1859156070591560767mer-m85915605659156077149-15.11
ADediting_695931chr18_59156103_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-1976chr1859156100591561067mer-m85915608759156107149-26.06
ADediting_695931chr18_59156103_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-660-3pchr1859156101591561088mer-1a5915608959156108144-16.11
ADediting_695931chr18_59156103_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-6747-3pchr1859156098591561058mer-1a5915608459156105150-24.16
ADediting_695932chr18_59156112_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-1245achr1859156107591561137mer-m85915609459156114149-18.4
ADediting_695933chr18_59156122_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-10400-3pchr1859156115591561217mer-m85915610159156122140-21.46
ADediting_695933chr18_59156122_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-1343-3pchr1859156118591561247mer-m85915610459156125140-20.74
ADediting_695933chr18_59156122_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-4674chr1859156115591561217mer-m85915610259156122147-22.8
ADediting_695933chr18_59156122_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-6783-3pchr1859156118591561247mer-m85915610459156125151-25.03
ADediting_695933chr18_59156122_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-939-3pchr1859156117591561248mer-1a5915610259156124148-23.07

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-589-3pchr1859157090591570967mer-m85915707659157097156-20

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_843620chr2_207754818_+ENSG00000166562.9ENST00000509791.7SEC11C-202hsa-miR-4775chr1859155863591558697mer-1a5915584759155869146-9.92

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for SEC11C

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000509791.7protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_695926ENST00000509791.7chr18_59156053_+796-572.10-569.00-579.40
ADediting_695927ENST00000509791.7chr18_59156059_+802-569.90-569.00-579.40
ADediting_695928ENST00000509791.7chr18_59156069_+812-570.20-569.00-579.40
ADediting_695929ENST00000509791.7chr18_59156076_+819-570.20-569.00-579.40
ADediting_695930ENST00000509791.7chr18_59156099_+842-572.10-569.00-579.40
ADediting_695931ENST00000509791.7chr18_59156103_+846-569.40-569.00-579.40
ADediting_695932ENST00000509791.7chr18_59156112_+855-570.00-569.00-579.40
ADediting_695933ENST00000509791.7chr18_59156122_+865-568.20-569.00-579.40
ADediting_695934ENST00000509791.7chr18_59156150_+893-572.00-569.00-579.40

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for SEC11C

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_695846chr18_59153582_+2.72886621868412e-110.3665262233789093.69942409958672e-070.2839241332464243.20073059024959e-060.260983940439059
CERADediting_695846chr18_59153582_+1.48359306945556e-080.4420687094270231.66708528650721e-050.3436405186922150.2331412948250410.097936435755598
CERADediting_695852chr18_59153631_+1.76144500227579e-060.3787379648789370.00222538322375530.2478799810725830.2492414838409920.0946566716846244
CERADediting_695853chr18_59153650_+1.90187531696207e-070.4098792464114991.1624971604675e-050.3495578328900110.7306017153904210.0283455096052853
DLPFCADediting_695856chr18_59153763_+7.05582427947937e-050.2237656267454330.00661305150756590.153944309195291.27301005804497e-080.316103894075054
CERADediting_695859chr18_59153793_+8.29920083405379e-080.4207159917987751.19131032529446e-060.3844456220089050.2579083324213850.0929516791741998
CERADediting_695862chr18_59153810_+2.1785837823487e-070.4080671902052082.825859334596e-060.3716919561846360.3474030230259560.0772526870246745
TCXADediting_695862chr18_59153810_+5.31066160324174e-050.3237639361928940.1824789242427880.1094404093211220.002768226756663130.242692466699208
DLPFCADediting_695869chr18_59153890_+1.58435039552508e-080.3141283249866748.43800429019416e-050.2214169282871586.11695209864703e-120.377556182532316
DLPFCADediting_695874chr18_59153941_+8.07254219129446e-090.3201713093698341.06291558221164e-050.2472332518663121.20490616040424e-080.316598103989799
DLPFCADediting_695875chr18_59153969_+5.298660769059e-060.2553041499332540.003200221936144150.1669231235818941.47013915090596e-080.314805512393141
DLPFCADediting_695876chr18_59153975_+6.10896334230483e-110.3604034312146851.92935479438952e-080.3123369789517421.04828316540541e-060.273112607054886
CERADediting_695876chr18_59153975_+0.0006928060372836950.2739620221475984.99116347155943e-050.3248638316918140.5160709252574430.0534335144446837
CERADediting_695878chr18_59154810_+5.07581605721003e-050.3245661168505380.02998035432935090.1772852077376680.1794357076784990.110201935647492
DLPFCADediting_695879chr18_59154811_+3.05552101167549e-080.3081095817490464.95082659300314e-060.2560770201994680.001019018036205180.185712597618981
DLPFCADediting_695880chr18_59154816_+3.38517895792173e-100.3469433951181011.12144403998957e-090.337132494834154.72319754987528e-050.22894706011929
DLPFCADediting_695882chr18_59154833_+8.59102325068372e-100.3393450257121072.53293849754778e-090.3302568794723510.0002321635428809910.207632343583294
DLPFCADediting_695884chr18_59154856_+5.77758097385098e-090.3231199478806088.29815934762618e-080.2986858873792562.64810968628638e-050.236214259261197
CERADediting_695895chr18_59154905_+0.004682718963783250.2297372780794870.0001275888761554060.3077532281419150.767335523033621-0.0243572002699103
DLPFCADediting_695901chr18_59154913_+0.01723790741828680.1351900301382690.3996841236112270.04799925131497812.77663674129999e-150.42861065329425
TCXADediting_695912chr18_59154985_+0.01025178370382430.2090401820897730.881180093313187-0.01230694373850221.05306057588127e-050.351160047892365
CERADediting_695913chr18_59154986_+2.75880805060275e-070.4048915536689236.71485377105882e-060.3583439220868330.2750723723608790.089687538873439
DLPFCADediting_695915chr18_59154997_+4.07853416647403e-120.3804753521315527.40367824744915e-100.3405724192992014.29642872463865e-060.257682814257312
CERADediting_695915chr18_59154997_+5.36288296102183e-080.4262726130441231.11237515032415e-060.3854351662071210.02270336782452630.185959668946125
CERADediting_695917chr18_59155006_+6.25088205452399e-050.3208540282671870.0007462596991980820.2723762415562860.424082109395829-0.0657467562523947
DLPFCADediting_695918chr18_59155010_+2.01999660135805e-090.332183555449122.95135850959749e-080.3084308273281940.007408432464702120.151825409254281
CERADediting_695918chr18_59155010_+6.28904807613428e-070.3935437442698162.00087396051474e-060.3768543212947170.7398275344489960.0273379867571195
DLPFCADediting_695921chr18_59155026_+2.19143496443863e-090.3314915061824521.3737374033971e-080.3154179225367520.01343262059834890.140276980367709
CERADediting_695921chr18_59155026_+2.11006382073191e-060.3760655309325712.9089104350589e-060.3712547491592960.1508192539926180.117878199815976
CERADediting_695926chr18_59156053_+0.2163192476793530.1015378713343390.5425752893977540.05010629542768084.09311504626428e-050.328352082149623

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.82018089413658e-320.6045477232588631.240289620526e-280.5746056872246040.009174606958890280.147764963193199
AC4.67122507341604e-590.8085899645192291.580221689832e-290.6341377996790471.27061348492771e-230.577351326618648
PCC2.66831740916744e-210.6155210835450382.53973582611914e-180.57667898550530.0007223040453307390.242566750962943
CER1.20997174654787e-070.4158363581593352.00295297434567e-050.3405812070675731.76594799239784e-110.513798841133374
TCX4.47951778891553e-170.6165549275975120.06515600450942270.150975847726182.42348697291964e-160.604973200688657
FP1.66234460848994e-070.3801274884850531.39257686007356e-070.3823148918268890.844154061775547-0.0148382290629035
IFG0.04080953387468510.4118190952621060.3072665087755760.2127367554947330.6541167350864350.0942347007010603
PG1.58958703725793e-320.7322838055851571.69853802060765e-130.5061984174986730.1828038211840740.0981051136141525
STG2.43183979349445e-050.4431095739416110.0001427403984936570.4032571859935050.385135693493197-0.0959772226482482

Top

Relation with AD stages for SEC11C

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
TCXADediting_695859chr18_59153793_+0.0009524882109049370.316397024831228
TCXADediting_695912chr18_59154985_+0.0006685309685891040.325270861985957

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER4.76498443357278e-050.380907857073411
TCX1.11792747412402e-050.412424705811059

Top

RelatedDrugs for SEC11C

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SEC11C

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource