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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

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Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for DYNLL1

check button Gene summary
Gene informationGene symbol

DYNLL1

Gene ID

8655

Gene namedynein light chain LC8-type 1
SynonymsDLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|PIN|hdlc1
Cytomap

12q24.31

Type of geneprotein-coding
Descriptiondynein light chain 1, cytoplasmic8 kDa dynein light chaincytoplasmic dynein light polypeptidedynein, cytoplasmic, light polypeptide 1protein inhibitor of neuronal nitric oxide synthase
Modification date20200322
UniProtAcc

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
DYNLL1

GO:0042326

negative regulation of phosphorylation

18579519


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RNA A-to-I events for DYNLL1

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_314552(120470490, +), ADediting_314553(120470523, +), ADediting_314554(120470580, +), ADediting_314555(120470699, +), ADediting_314556(120470710, +), ADediting_314557(120470790, +), ADediting_314558(120470796, +), ADediting_314559(120470804, +), ADediting_314560(120470825, +), ADediting_314561(120470858, +), ADediting_314562(120470859, +), ADediting_314563(120470880, +), ADediting_314564(120470884, +), ADediting_314565(120470887, +), ADediting_314566(120470922, +), ADediting_314567(120470924, +), ADediting_314568(120470925, +), ADediting_314569(120470951, +), ADediting_314570(120471108, +), ADediting_314571(120471109, +), ADediting_314572(120471122, +), ADediting_314573(120471163, +), ADediting_314574(120471185, +), ADediting_314575(120471186, +), ADediting_314576(120471232, +), ADediting_314577(120471233, +), ADediting_314578(120471252, +), ADediting_314579(120471279, +), ADediting_314580(120471285, +), ADediting_314581(120471294, +), ADediting_314582(120471305, +), ADediting_314583(120471314, +), ADediting_314584(120471318, +), ADediting_314585(120471333, +), ADediting_314586(120471380, +), ADediting_314587(120471630, +), ADediting_314588(120471632, +), ADediting_314589(120471685, +), ADediting_314590(120471691, +), ADediting_314591(120471740, +), ADediting_314592(120471750, +), ADediting_314593(120471752, +), ADediting_314594(120471785, +), ADediting_314595(120471793, +), ADediting_314596(120471796, +), ADediting_314597(120471810, +), ADediting_314598(120471818, +), ADediting_314599(120471863, +), ADediting_314600(120471872, +), ADediting_314601(120471873, +), ADediting_314602(120471883, +), ADediting_314603(120471885, +), ADediting_314604(120471887, +), ADediting_314605(120473330, +), ADediting_314606(120473368, +), ADediting_314607(120473575, +), ADediting_314608(120473927, +), ADediting_314609(120474121, +), ADediting_314610(120474177, +), ADediting_314611(120476630, +), ADediting_314612(120476634, +), ADediting_314613(120476705, +), ADediting_314614(120476741, +), ADediting_314615(120476792, +), ADediting_314616(120477724, +), ADediting_314617(120478237, +), ADediting_314618(120478466, +), ADediting_314619(120478508, +), ADediting_314620(120478824, +), ADediting_314621(120478869, +), ADediting_314622(120479119, +), ADediting_314623(120479307, +), ADediting_314624(120482987, +), ADediting_314625(120483227, +), ADediting_314626(120484797, +), ADediting_314627(120484803, +), ADediting_314628(120484844, +), ADediting_314629(120484912, +), ADediting_314630(120484942, +), ADediting_314631(120485014, +), ADediting_314632(120485083, +), ADediting_314633(120485694, +), ADediting_314634(120485714, +), ADediting_314635(120487181, +), ADediting_1530631(120470819, +), ADediting_1530632(120470883, +), ADediting_1530633(120470886, +), ADediting_1530634(120470892, +), ADediting_1530635(120471269, +), ADediting_1530636(120471307, +),

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RNA editing positional annotations for DYNLL1 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_314552chr12_120470490_+intronic
ADediting_314553chr12_120470523_+intronic
ADediting_314554chr12_120470580_+intronic
ADediting_314555chr12_120470699_+intronic
ADediting_314556chr12_120470710_+intronic
ADediting_314557chr12_120470790_+intronic
ADediting_314558chr12_120470796_+intronic
ADediting_314559chr12_120470804_+intronic
ADediting_314560chr12_120470825_+intronic
ADediting_314561chr12_120470858_+intronic
ADediting_314562chr12_120470859_+intronic
ADediting_314563chr12_120470880_+intronic
ADediting_314564chr12_120470884_+intronic
ADediting_314565chr12_120470887_+intronic
ADediting_314566chr12_120470922_+intronic
ADediting_314567chr12_120470924_+intronic
ADediting_314568chr12_120470925_+intronic
ADediting_314569chr12_120470951_+intronic
ADediting_314570chr12_120471108_+intronic
ADediting_314571chr12_120471109_+intronic
ADediting_314572chr12_120471122_+intronic
ADediting_314573chr12_120471163_+intronic
ADediting_314574chr12_120471185_+intronic
ADediting_314575chr12_120471186_+intronic
ADediting_314576chr12_120471232_+intronic
ADediting_314577chr12_120471233_+intronic
ADediting_314578chr12_120471252_+intronic
ADediting_314579chr12_120471279_+intronic
ADediting_314580chr12_120471285_+intronic
ADediting_314581chr12_120471294_+intronic
ADediting_314582chr12_120471305_+intronic
ADediting_314583chr12_120471314_+intronic
ADediting_314584chr12_120471318_+intronic
ADediting_314585chr12_120471333_+intronic
ADediting_314586chr12_120471380_+intronic
ADediting_314587chr12_120471630_+intronic
ADediting_314588chr12_120471632_+intronic
ADediting_314589chr12_120471685_+intronic
ADediting_314590chr12_120471691_+intronic
ADediting_314591chr12_120471740_+intronic
ADediting_314592chr12_120471750_+intronic
ADediting_314593chr12_120471752_+intronic
ADediting_314594chr12_120471785_+intronic
ADediting_314595chr12_120471793_+intronic
ADediting_314596chr12_120471796_+intronic
ADediting_314597chr12_120471810_+intronic
ADediting_314598chr12_120471818_+intronic
ADediting_314599chr12_120471863_+intronic
ADediting_314600chr12_120471872_+intronic
ADediting_314601chr12_120471873_+intronic
ADediting_314602chr12_120471883_+intronic
ADediting_314603chr12_120471885_+intronic
ADediting_314604chr12_120471887_+intronic
ADediting_314605chr12_120473330_+intronic
ADediting_314606chr12_120473368_+intronic
ADediting_314607chr12_120473575_+intronic
ADediting_314608chr12_120473927_+intronic
ADediting_314609chr12_120474121_+intronic
ADediting_314610chr12_120474177_+intronic
ADediting_314611chr12_120476630_+intronic
ADediting_314612chr12_120476634_+intronic
ADediting_314613chr12_120476705_+intronic
ADediting_314614chr12_120476741_+intronic
ADediting_314615chr12_120476792_+intronic
ADediting_314616chr12_120477724_+intronic
ADediting_314617chr12_120478237_+intronic
ADediting_314618chr12_120478466_+intronic
ADediting_314619chr12_120478508_+intronic
ADediting_314620chr12_120478824_+intronic
ADediting_314621chr12_120478869_+intronic
ADediting_314622chr12_120479119_+intronic
ADediting_314623chr12_120479307_+intronic
ADediting_314624chr12_120482987_+intronic
ADediting_314625chr12_120483227_+intronic
ADediting_314626chr12_120484797_+intronic
ADediting_314627chr12_120484803_+intronic
ADediting_314628chr12_120484844_+intronic
ADediting_314629chr12_120484912_+intronic
ADediting_314630chr12_120484942_+intronic
ADediting_314631chr12_120485014_+intronic
ADediting_314632chr12_120485083_+intronic
ADediting_314633chr12_120485694_+intronic
ADediting_314634chr12_120485714_+intronic
ADediting_314635chr12_120487181_+intronic
ADediting_1530631chr12_120470819_+intronic
ADediting_1530632chr12_120470883_+intronic
ADediting_1530633chr12_120470886_+intronic
ADediting_1530634chr12_120470892_+intronic
ADediting_1530635chr12_120471269_+intronic
ADediting_1530636chr12_120471307_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_314552chr12_120470490_+SINEAluName=AluJb
ADediting_314553chr12_120470523_+SINEAluName=AluJb
ADediting_314554chr12_120470580_+SINEAluName=AluJb
ADediting_314555chr12_120470699_+SINEAluName=AluJb
ADediting_314556chr12_120470710_+SINEAluName=AluJb
ADediting_314557chr12_120470790_+SINEAluName=AluSz
ADediting_314558chr12_120470796_+SINEAluName=AluSz
ADediting_314559chr12_120470804_+SINEAluName=AluSz
ADediting_314560chr12_120470825_+SINEAluName=AluSz
ADediting_314561chr12_120470858_+SINEAluName=AluSz
ADediting_314562chr12_120470859_+SINEAluName=AluSz
ADediting_314563chr12_120470880_+SINEAluName=AluSz
ADediting_314564chr12_120470884_+SINEAluName=AluSz
ADediting_314565chr12_120470887_+SINEAluName=AluSz
ADediting_314566chr12_120470922_+SINEAluName=AluSz
ADediting_314567chr12_120470924_+SINEAluName=AluSz
ADediting_314568chr12_120470925_+SINEAluName=AluSz
ADediting_314569chr12_120470951_+SINEAluName=AluSz
ADediting_314570chr12_120471108_+SINEAluName=AluSz6
ADediting_314571chr12_120471109_+SINEAluName=AluSz6
ADediting_314572chr12_120471122_+SINEAluName=AluSz6
ADediting_314573chr12_120471163_+SINEAluName=AluSz6
ADediting_314574chr12_120471185_+SINEAluName=AluSz6
ADediting_314575chr12_120471186_+SINEAluName=AluSz6
ADediting_314576chr12_120471232_+SINEAluName=AluSz6
ADediting_314577chr12_120471233_+SINEAluName=AluSz6
ADediting_314578chr12_120471252_+SINEAluName=AluSz6
ADediting_314579chr12_120471279_+SINEAluName=AluSz6
ADediting_314580chr12_120471285_+SINEAluName=AluSz6
ADediting_314581chr12_120471294_+SINEAluName=AluSz6
ADediting_314582chr12_120471305_+SINEAluName=AluSz6
ADediting_314583chr12_120471314_+SINEAluName=AluSz6
ADediting_314584chr12_120471318_+SINEAluName=AluSz6
ADediting_314585chr12_120471333_+SINEAluName=AluSz6
ADediting_314586chr12_120471380_+SINEAluName=AluSz6
ADediting_314587chr12_120471630_+SINEAluName=AluY
ADediting_314588chr12_120471632_+SINEAluName=AluY
ADediting_314589chr12_120471685_+SINEAluName=AluY
ADediting_314590chr12_120471691_+SINEAluName=AluY
ADediting_314591chr12_120471740_+SINEAluName=AluY
ADediting_314592chr12_120471750_+SINEAluName=AluY
ADediting_314593chr12_120471752_+SINEAluName=AluY
ADediting_314594chr12_120471785_+SINEAluName=AluY
ADediting_314595chr12_120471793_+SINEAluName=AluY
ADediting_314596chr12_120471796_+SINEAluName=AluY
ADediting_314597chr12_120471810_+SINEAluName=AluY
ADediting_314598chr12_120471818_+SINEAluName=AluY
ADediting_314599chr12_120471863_+SINEAluName=AluY
ADediting_314600chr12_120471872_+SINEAluName=AluY
ADediting_314601chr12_120471873_+SINEAluName=AluY
ADediting_314602chr12_120471883_+SINEAluName=AluY
ADediting_314603chr12_120471885_+SINEAluName=AluY
ADediting_314604chr12_120471887_+SINEAluName=AluY
ADediting_314605chr12_120473330_+SINEAluName=AluJb
ADediting_314606chr12_120473368_+SINEAluName=AluJb
ADediting_314607chr12_120473575_+SINEAluName=AluSz6
ADediting_314608chr12_120473927_+SINEAluName=AluJb
ADediting_314609chr12_120474121_+SINEAluName=AluJb
ADediting_314610chr12_120474177_+SINEAluName=AluJb
ADediting_314611chr12_120476630_+SINEAluName=AluSp
ADediting_314612chr12_120476634_+SINEAluName=AluSp
ADediting_314613chr12_120476705_+SINEAluName=AluSp
ADediting_314614chr12_120476741_+SINEAluName=AluSp
ADediting_314615chr12_120476792_+SINEAluName=AluSp
ADediting_314616chr12_120477724_+SINEAluName=AluJo
ADediting_314617chr12_120478237_+SINEAluName=AluSp
ADediting_314618chr12_120478466_+SINEAluName=FLAM_C
ADediting_314619chr12_120478508_+SINEAluName=FLAM_C
ADediting_314620chr12_120478824_+SINEAluName=AluSx1
ADediting_314621chr12_120478869_+SINEAluName=AluSx1
ADediting_314622chr12_120479119_+SINEAluName=AluSx1
ADediting_314623chr12_120479307_+SINEAluName=AluSp
ADediting_314624chr12_120482987_+SINEAluName=AluJo
ADediting_314625chr12_120483227_+SINEAluName=AluSg
ADediting_314626chr12_120484797_+SINEAluName=AluSz
ADediting_314627chr12_120484803_+SINEAluName=AluSz
ADediting_314628chr12_120484844_+SINEAluName=AluSz
ADediting_314629chr12_120484912_+SINEAluName=AluSz
ADediting_314630chr12_120484942_+SINEAluName=AluSz
ADediting_314631chr12_120485014_+SINEAluName=AluSz
ADediting_314632chr12_120485083_+SINEAluName=FRAM
ADediting_314633chr12_120485694_+SINEAluName=AluJo
ADediting_314634chr12_120485714_+SINEAluName=AluJo
ADediting_314635chr12_120487181_+SINEAluName=AluY
ADediting_1530631chr12_120470819_+SINEAluName=AluSz
ADediting_1530632chr12_120470883_+SINEAluName=AluSz
ADediting_1530633chr12_120470886_+SINEAluName=AluSz
ADediting_1530634chr12_120470892_+SINEAluName=AluSz
ADediting_1530635chr12_120471269_+SINEAluName=AluSz6
ADediting_1530636chr12_120471307_+SINEAluName=AluSz6

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RNA A-to-I editing events in the alternative splicing sites for DYNLL1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_314552chr12_120470490_+120470472:1204704943ss2iTTTGTTTGTTTTTGATACAGGGT8.06TTTGTTTGTTTTTGATACGGGGT0.11
ESADediting_314552chr12_120470490_+120470472:1204704943ss2iTTTGTTTGTTTTTGATACAGGGT8.06TTTGTTTGTTTTTGATACGGGGT0.11

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DYNLL1

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs