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	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene

Gene summary for RTCA

Gene summary

Gene information	Gene symbol	RTCA
	Gene ID	8634
	Gene name	RNA 3'-terminal phosphate cyclase
	Synonyms	RPC|RTC1|RTCD1
	Cytomap	1p21.2
	Type of gene	protein-coding
	Description	RNA 3'-terminal phosphate cyclaseRNA terminal phosphate cyclase domain 1RNA terminal phosphate cyclase domain-containing protein 1RTC domain-containing protein 1
	Modification date	20200313
	UniProtAcc	O00442,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for RTCA

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_464(100268585, +), ADediting_465(100268586, +), ADediting_466(100268933, +), ADediting_467(100276042, +), ADediting_468(100276071, +), ADediting_469(100276423, +), ADediting_470(100276424, +), ADediting_471(100276491, +), ADediting_472(100276556, +), ADediting_473(100276659, +), ADediting_474(100280793, +), ADediting_475(100280800, +), ADediting_476(100280807, +), ADediting_477(100280929, +), ADediting_478(100280934, +), ADediting_479(100280964, +), ADediting_480(100280984, +), ADediting_481(100280997, +), ADediting_482(100281743, +), ADediting_483(100281765, +), ADediting_484(100281773, +), ADediting_485(100281780, +), ADediting_486(100281842, +), ADediting_487(100281913, +), ADediting_488(100281925, +), ADediting_489(100281968, +), ADediting_490(100283839, +), ADediting_491(100283841, +), ADediting_492(100283856, +), ADediting_493(100283897, +), ADediting_494(100284603, +), ADediting_495(100284656, +), ADediting_496(100284659, +), ADediting_497(100286190, +), ADediting_498(100286197, +), ADediting_499(100286203, +), ADediting_500(100286307, +), ADediting_501(100286333, +), ADediting_502(100286339, +), ADediting_503(100286343, +), ADediting_504(100287887, +), ADediting_505(100287893, +), ADediting_506(100287894, +), ADediting_507(100287927, +), ADediting_508(100288923, +), ADediting_509(100290326, +), ADediting_510(100290335, +), ADediting_511(100290347, +), ADediting_512(100290358, +), ADediting_513(100290396, +), ADediting_514(100290493, +), ADediting_515(100290497, +), ADediting_516(100290500, +), ADediting_517(100290529, +), ADediting_518(100290533, +), ADediting_519(100290542, +), ADediting_520(100290561, +), ADediting_521(100290619, +), ADediting_522(100290623, +), ADediting_523(100290627, +), ADediting_524(100290672, +), ADediting_525(100290687, +), ADediting_526(100290691, +), ADediting_527(100290695, +), ADediting_528(100290753, +), ADediting_529(100292027, +), ADediting_530(100292028, +), ADediting_531(100292031, +), ADediting_532(100292032, +), ADediting_533(100292103, +), ADediting_534(100292122, +), ADediting_535(100292327, +), ADediting_536(100292335, +), ADediting_537(100292343, +), ADediting_538(100292347, +), ADediting_539(100292367, +), ADediting_540(100292372, +), ADediting_541(100292420, +), ADediting_542(100292432, +), ADediting_543(100292448, +), ADediting_544(100292464, +), ADediting_1513552(100282855, +), ADediting_1513553(100282949, +), ADediting_1513554(100283006, +), ADediting_1513555(100283011, +), ADediting_1513556(100283032, +), ADediting_1513557(100283060, +), ADediting_1513558(100283424, +), ADediting_1513559(100284807, +), ADediting_1513560(100284812, +), ADediting_1513561(100284836, +), ADediting_1513562(100284850, +), ADediting_1513563(100288659, +), ADediting_1513564(100288916, +), ADediting_1513565(100288940, +), ADediting_1513566(100288952, +), ADediting_1513567(100288964, +), ADediting_1513568(100289029, +), ADediting_1513569(100290346, +), ADediting_1513570(100290668, +), ADediting_1513571(100290707, +), ADediting_1513572(100290748, +), ADediting_1513573(100291967, +), ADediting_1595751(100268623, +), ADediting_1595752(100268630, +), ADediting_1595753(100268633, +), ADediting_1595754(100268657, +), ADediting_1595755(100268672, +), ADediting_1595756(100271389, +), ADediting_1595757(100276078, +), ADediting_1595758(100276115, +), ADediting_1595759(100281820, +), ADediting_1595760(100285753, +),

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RNA editing positional annotations for RTCA using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_464	chr1_100268585_+	intronic
ADediting_465	chr1_100268586_+	intronic
ADediting_466	chr1_100268933_+	intronic
ADediting_467	chr1_100276042_+	intronic
ADediting_468	chr1_100276071_+	intronic
ADediting_469	chr1_100276423_+	intronic
ADediting_470	chr1_100276424_+	intronic
ADediting_471	chr1_100276491_+	intronic
ADediting_472	chr1_100276556_+	intronic
ADediting_473	chr1_100276659_+	intronic
ADediting_474	chr1_100280793_+	intronic
ADediting_475	chr1_100280800_+	intronic
ADediting_476	chr1_100280807_+	intronic
ADediting_477	chr1_100280929_+	intronic
ADediting_478	chr1_100280934_+	intronic
ADediting_479	chr1_100280964_+	intronic
ADediting_480	chr1_100280984_+	intronic
ADediting_481	chr1_100280997_+	intronic
ADediting_482	chr1_100281743_+	intronic
ADediting_483	chr1_100281765_+	intronic
ADediting_484	chr1_100281773_+	intronic
ADediting_485	chr1_100281780_+	intronic
ADediting_486	chr1_100281842_+	intronic
ADediting_487	chr1_100281913_+	intronic
ADediting_488	chr1_100281925_+	intronic
ADediting_489	chr1_100281968_+	intronic
ADediting_490	chr1_100283839_+	intronic
ADediting_491	chr1_100283841_+	intronic
ADediting_492	chr1_100283856_+	intronic
ADediting_493	chr1_100283897_+	intronic
ADediting_494	chr1_100284603_+	intronic
ADediting_495	chr1_100284656_+	intronic
ADediting_496	chr1_100284659_+	intronic
ADediting_497	chr1_100286190_+	intronic
ADediting_498	chr1_100286197_+	intronic
ADediting_499	chr1_100286203_+	intronic
ADediting_500	chr1_100286307_+	intronic
ADediting_501	chr1_100286333_+	intronic
ADediting_502	chr1_100286339_+	intronic
ADediting_503	chr1_100286343_+	intronic
ADediting_504	chr1_100287887_+	intronic
ADediting_505	chr1_100287893_+	intronic
ADediting_506	chr1_100287894_+	intronic
ADediting_507	chr1_100287927_+	intronic
ADediting_508	chr1_100288923_+	intronic
ADediting_509	chr1_100290326_+	intronic
ADediting_510	chr1_100290335_+	intronic
ADediting_511	chr1_100290347_+	intronic
ADediting_512	chr1_100290358_+	intronic
ADediting_513	chr1_100290396_+	intronic
ADediting_514	chr1_100290493_+	intronic
ADediting_515	chr1_100290497_+	intronic
ADediting_516	chr1_100290500_+	intronic
ADediting_517	chr1_100290529_+	intronic
ADediting_518	chr1_100290533_+	intronic
ADediting_519	chr1_100290542_+	intronic
ADediting_520	chr1_100290561_+	intronic
ADediting_521	chr1_100290619_+	intronic
ADediting_522	chr1_100290623_+	intronic
ADediting_523	chr1_100290627_+	intronic
ADediting_524	chr1_100290672_+	intronic
ADediting_525	chr1_100290687_+	intronic
ADediting_526	chr1_100290691_+	intronic
ADediting_527	chr1_100290695_+	intronic
ADediting_528	chr1_100290753_+	intronic
ADediting_529	chr1_100292027_+	UTR3
ADediting_530	chr1_100292028_+	UTR3
ADediting_531	chr1_100292031_+	UTR3
ADediting_532	chr1_100292032_+	UTR3
ADediting_533	chr1_100292103_+	UTR3
ADediting_534	chr1_100292122_+	UTR3
ADediting_535	chr1_100292327_+	UTR3
ADediting_536	chr1_100292335_+	UTR3
ADediting_537	chr1_100292343_+	UTR3
ADediting_538	chr1_100292347_+	UTR3
ADediting_539	chr1_100292367_+	UTR3
ADediting_540	chr1_100292372_+	UTR3
ADediting_541	chr1_100292420_+	UTR3
ADediting_542	chr1_100292432_+	UTR3
ADediting_543	chr1_100292448_+	UTR3
ADediting_544	chr1_100292464_+	UTR3
ADediting_1513552	chr1_100282855_+	intronic
ADediting_1513553	chr1_100282949_+	intronic
ADediting_1513554	chr1_100283006_+	intronic
ADediting_1513555	chr1_100283011_+	intronic
ADediting_1513556	chr1_100283032_+	intronic
ADediting_1513557	chr1_100283060_+	intronic
ADediting_1513558	chr1_100283424_+	intronic
ADediting_1513559	chr1_100284807_+	intronic
ADediting_1513560	chr1_100284812_+	intronic
ADediting_1513561	chr1_100284836_+	intronic
ADediting_1513562	chr1_100284850_+	intronic
ADediting_1513563	chr1_100288659_+	intronic
ADediting_1513564	chr1_100288916_+	intronic
ADediting_1513565	chr1_100288940_+	intronic
ADediting_1513566	chr1_100288952_+	intronic
ADediting_1513567	chr1_100288964_+	intronic
ADediting_1513568	chr1_100289029_+	intronic
ADediting_1513569	chr1_100290346_+	intronic
ADediting_1513570	chr1_100290668_+	intronic
ADediting_1513571	chr1_100290707_+	intronic
ADediting_1513572	chr1_100290748_+	intronic
ADediting_1513573	chr1_100291967_+	UTR3
ADediting_1595751	chr1_100268623_+	intronic
ADediting_1595752	chr1_100268630_+	intronic
ADediting_1595753	chr1_100268633_+	intronic
ADediting_1595754	chr1_100268657_+	intronic
ADediting_1595755	chr1_100268672_+	intronic
ADediting_1595756	chr1_100271389_+	intronic
ADediting_1595757	chr1_100276078_+	intronic
ADediting_1595758	chr1_100276115_+	intronic
ADediting_1595759	chr1_100281820_+	intronic
ADediting_1595760	chr1_100285753_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_464	chr1_100268585_+	SINE	Alu	Name=AluJo
ADediting_465	chr1_100268586_+	SINE	Alu	Name=AluJo
ADediting_466	chr1_100268933_+	SINE	Alu	Name=AluJb
ADediting_467	chr1_100276042_+	SINE	Alu	Name=AluY
ADediting_468	chr1_100276071_+	SINE	Alu	Name=AluY
ADediting_469	chr1_100276423_+	SINE	Alu	Name=AluSc
ADediting_470	chr1_100276424_+	SINE	Alu	Name=AluSc
ADediting_471	chr1_100276491_+	SINE	Alu	Name=AluSc
ADediting_472	chr1_100276556_+	SINE	Alu	Name=AluSc
ADediting_473	chr1_100276659_+	SINE	Alu	Name=AluSc
ADediting_474	chr1_100280793_+	SINE	Alu	Name=AluJb
ADediting_475	chr1_100280800_+	SINE	Alu	Name=AluJb
ADediting_476	chr1_100280807_+	SINE	Alu	Name=AluJb
ADediting_477	chr1_100280929_+	SINE	Alu	Name=AluJb
ADediting_478	chr1_100280934_+	SINE	Alu	Name=AluJb
ADediting_479	chr1_100280964_+	SINE	Alu	Name=AluJb
ADediting_480	chr1_100280984_+	SINE	Alu	Name=AluJb
ADediting_481	chr1_100280997_+	SINE	Alu	Name=AluJb
ADediting_482	chr1_100281743_+	SINE	Alu	Name=AluSz
ADediting_483	chr1_100281765_+	SINE	Alu	Name=AluSz
ADediting_484	chr1_100281773_+	SINE	Alu	Name=AluSz
ADediting_485	chr1_100281780_+	SINE	Alu	Name=AluSz
ADediting_486	chr1_100281842_+	SINE	Alu	Name=AluSz
ADediting_487	chr1_100281913_+	SINE	Alu	Name=AluSz
ADediting_488	chr1_100281925_+	SINE	Alu	Name=AluSz
ADediting_489	chr1_100281968_+	SINE	Alu	Name=AluSz
ADediting_490	chr1_100283839_+	SINE	Alu	Name=FLAM_C
ADediting_491	chr1_100283841_+	SINE	Alu	Name=FLAM_C
ADediting_492	chr1_100283856_+	SINE	Alu	Name=FLAM_C
ADediting_493	chr1_100283897_+	SINE	Alu	Name=FLAM_C
ADediting_494	chr1_100284603_+	SINE	Alu	Name=AluSz6
ADediting_495	chr1_100284656_+	SINE	Alu	Name=AluSz6
ADediting_496	chr1_100284659_+	SINE	Alu	Name=AluSz6
ADediting_497	chr1_100286190_+	SINE	Alu	Name=AluYm1
ADediting_498	chr1_100286197_+	SINE	Alu	Name=AluYm1
ADediting_499	chr1_100286203_+	SINE	Alu	Name=AluYm1
ADediting_500	chr1_100286307_+	SINE	Alu	Name=AluYm1
ADediting_501	chr1_100286333_+	SINE	Alu	Name=AluYm1
ADediting_502	chr1_100286339_+	SINE	Alu	Name=AluYm1
ADediting_503	chr1_100286343_+	SINE	Alu	Name=AluYm1
ADediting_504	chr1_100287887_+	SINE	Alu	Name=AluSx
ADediting_505	chr1_100287893_+	SINE	Alu	Name=AluSx
ADediting_506	chr1_100287894_+	SINE	Alu	Name=AluSx
ADediting_507	chr1_100287927_+	SINE	Alu	Name=AluSx
ADediting_508	chr1_100288923_+	SINE	Alu	Name=AluSz6
ADediting_509	chr1_100290326_+	SINE	Alu	Name=FLAM_C
ADediting_510	chr1_100290335_+	SINE	Alu	Name=FLAM_C
ADediting_511	chr1_100290347_+	SINE	Alu	Name=FLAM_C
ADediting_512	chr1_100290358_+	SINE	Alu	Name=FLAM_C
ADediting_513	chr1_100290396_+	SINE	Alu	Name=FLAM_C
ADediting_514	chr1_100290493_+	SINE	Alu	Name=AluJb
ADediting_515	chr1_100290497_+	SINE	Alu	Name=AluJb
ADediting_516	chr1_100290500_+	SINE	Alu	Name=AluJb
ADediting_517	chr1_100290529_+	SINE	Alu	Name=AluJb
ADediting_518	chr1_100290533_+	SINE	Alu	Name=AluJb
ADediting_519	chr1_100290542_+	SINE	Alu	Name=AluJb
ADediting_520	chr1_100290561_+	SINE	Alu	Name=AluJb
ADediting_521	chr1_100290619_+	SINE	Alu	Name=AluJb
ADediting_522	chr1_100290623_+	SINE	Alu	Name=AluJb
ADediting_523	chr1_100290627_+	SINE	Alu	Name=AluJb
ADediting_524	chr1_100290672_+	SINE	Alu	Name=AluJb
ADediting_525	chr1_100290687_+	SINE	Alu	Name=AluJb
ADediting_526	chr1_100290691_+	SINE	Alu	Name=AluJb
ADediting_527	chr1_100290695_+	SINE	Alu	Name=AluJb
ADediting_528	chr1_100290753_+	SINE	Alu	Name=AluJb
ADediting_529	chr1_100292027_+	SINE	Alu	Name=AluSg
ADediting_530	chr1_100292028_+	SINE	Alu	Name=AluSg
ADediting_531	chr1_100292031_+	SINE	Alu	Name=AluSg
ADediting_532	chr1_100292032_+	SINE	Alu	Name=AluSg
ADediting_533	chr1_100292103_+	SINE	Alu	Name=AluSg
ADediting_534	chr1_100292122_+	SINE	Alu	Name=AluSg
ADediting_535	chr1_100292327_+	SINE	Alu	Name=AluSc
ADediting_536	chr1_100292335_+	SINE	Alu	Name=AluSc
ADediting_537	chr1_100292343_+	SINE	Alu	Name=AluSc
ADediting_538	chr1_100292347_+	SINE	Alu	Name=AluSc
ADediting_539	chr1_100292367_+	SINE	Alu	Name=AluSc
ADediting_540	chr1_100292372_+	SINE	Alu	Name=AluSc
ADediting_541	chr1_100292420_+	SINE	Alu	Name=AluSc
ADediting_542	chr1_100292432_+	SINE	Alu	Name=AluSc
ADediting_543	chr1_100292448_+	SINE	Alu	Name=AluSc
ADediting_544	chr1_100292464_+	SINE	Alu	Name=AluSc
ADediting_1513552	chr1_100282855_+	SINE	Alu	Name=AluSz
ADediting_1513553	chr1_100282949_+	SINE	Alu	Name=AluSz
ADediting_1513554	chr1_100283006_+	SINE	Alu	Name=AluSz
ADediting_1513555	chr1_100283011_+	SINE	Alu	Name=AluSz
ADediting_1513556	chr1_100283032_+	SINE	Alu	Name=AluSz
ADediting_1513557	chr1_100283060_+	SINE	Alu	Name=AluSz
ADediting_1513558	chr1_100283424_+	SINE	Alu	Name=AluSz
ADediting_1513559	chr1_100284807_+	SINE	Alu	Name=FLAM_C
ADediting_1513560	chr1_100284812_+	SINE	Alu	Name=FLAM_C
ADediting_1513561	chr1_100284836_+	SINE	Alu	Name=FLAM_C
ADediting_1513562	chr1_100284850_+	SINE	Alu	Name=FLAM_C
ADediting_1513563	chr1_100288659_+	SINE	Alu	Name=AluJo
ADediting_1513564	chr1_100288916_+	SINE	Alu	Name=AluSz6
ADediting_1513565	chr1_100288940_+	SINE	Alu	Name=AluSz6
ADediting_1513566	chr1_100288952_+	SINE	Alu	Name=AluSz6
ADediting_1513567	chr1_100288964_+	SINE	Alu	Name=AluSz6
ADediting_1513568	chr1_100289029_+	SINE	Alu	Name=AluSz6
ADediting_1513569	chr1_100290346_+	SINE	Alu	Name=FLAM_C
ADediting_1513570	chr1_100290668_+	SINE	Alu	Name=AluJb
ADediting_1513571	chr1_100290707_+	SINE	Alu	Name=AluJb
ADediting_1513572	chr1_100290748_+	SINE	Alu	Name=AluJb
ADediting_1513573	chr1_100291967_+	SINE	Alu	Name=AluSg
ADediting_1595751	chr1_100268623_+	SINE	Alu	Name=AluJo
ADediting_1595752	chr1_100268630_+	SINE	Alu	Name=AluJo
ADediting_1595753	chr1_100268633_+	SINE	Alu	Name=AluJo
ADediting_1595754	chr1_100268657_+	SINE	Alu	Name=AluJo
ADediting_1595755	chr1_100268672_+	SINE	Alu	Name=AluJo
ADediting_1595756	chr1_100271389_+	SINE	Alu	Name=AluJb
ADediting_1595757	chr1_100276078_+	SINE	Alu	Name=AluY
ADediting_1595758	chr1_100276115_+	SINE	Alu	Name=AluY
ADediting_1595759	chr1_100281820_+	SINE	Alu	Name=AluSz
ADediting_1595760	chr1_100285753_+	SINE	Alu	Name=AluJr4

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RNA A-to-I editing events in the alternative splicing sites for RTCA

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RTCA

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs