ADeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for RTCA

check button Gene summary
Gene informationGene symbol

RTCA

Gene ID

8634

Gene nameRNA 3'-terminal phosphate cyclase
SynonymsRPC|RTC1|RTCD1
Cytomap

1p21.2

Type of geneprotein-coding
DescriptionRNA 3'-terminal phosphate cyclaseRNA terminal phosphate cyclase domain 1RNA terminal phosphate cyclase domain-containing protein 1RTC domain-containing protein 1
Modification date20200313
UniProtAcc

O00442,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

Top

RNA A-to-I events for RTCA

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_464(100268585, +), ADediting_465(100268586, +), ADediting_466(100268933, +), ADediting_467(100276042, +), ADediting_468(100276071, +), ADediting_469(100276423, +), ADediting_470(100276424, +), ADediting_471(100276491, +), ADediting_472(100276556, +), ADediting_473(100276659, +), ADediting_474(100280793, +), ADediting_475(100280800, +), ADediting_476(100280807, +), ADediting_477(100280929, +), ADediting_478(100280934, +), ADediting_479(100280964, +), ADediting_480(100280984, +), ADediting_481(100280997, +), ADediting_482(100281743, +), ADediting_483(100281765, +), ADediting_484(100281773, +), ADediting_485(100281780, +), ADediting_486(100281842, +), ADediting_487(100281913, +), ADediting_488(100281925, +), ADediting_489(100281968, +), ADediting_490(100283839, +), ADediting_491(100283841, +), ADediting_492(100283856, +), ADediting_493(100283897, +), ADediting_494(100284603, +), ADediting_495(100284656, +), ADediting_496(100284659, +), ADediting_497(100286190, +), ADediting_498(100286197, +), ADediting_499(100286203, +), ADediting_500(100286307, +), ADediting_501(100286333, +), ADediting_502(100286339, +), ADediting_503(100286343, +), ADediting_504(100287887, +), ADediting_505(100287893, +), ADediting_506(100287894, +), ADediting_507(100287927, +), ADediting_508(100288923, +), ADediting_509(100290326, +), ADediting_510(100290335, +), ADediting_511(100290347, +), ADediting_512(100290358, +), ADediting_513(100290396, +), ADediting_514(100290493, +), ADediting_515(100290497, +), ADediting_516(100290500, +), ADediting_517(100290529, +), ADediting_518(100290533, +), ADediting_519(100290542, +), ADediting_520(100290561, +), ADediting_521(100290619, +), ADediting_522(100290623, +), ADediting_523(100290627, +), ADediting_524(100290672, +), ADediting_525(100290687, +), ADediting_526(100290691, +), ADediting_527(100290695, +), ADediting_528(100290753, +), ADediting_529(100292027, +), ADediting_530(100292028, +), ADediting_531(100292031, +), ADediting_532(100292032, +), ADediting_533(100292103, +), ADediting_534(100292122, +), ADediting_535(100292327, +), ADediting_536(100292335, +), ADediting_537(100292343, +), ADediting_538(100292347, +), ADediting_539(100292367, +), ADediting_540(100292372, +), ADediting_541(100292420, +), ADediting_542(100292432, +), ADediting_543(100292448, +), ADediting_544(100292464, +), ADediting_1513552(100282855, +), ADediting_1513553(100282949, +), ADediting_1513554(100283006, +), ADediting_1513555(100283011, +), ADediting_1513556(100283032, +), ADediting_1513557(100283060, +), ADediting_1513558(100283424, +), ADediting_1513559(100284807, +), ADediting_1513560(100284812, +), ADediting_1513561(100284836, +), ADediting_1513562(100284850, +), ADediting_1513563(100288659, +), ADediting_1513564(100288916, +), ADediting_1513565(100288940, +), ADediting_1513566(100288952, +), ADediting_1513567(100288964, +), ADediting_1513568(100289029, +), ADediting_1513569(100290346, +), ADediting_1513570(100290668, +), ADediting_1513571(100290707, +), ADediting_1513572(100290748, +), ADediting_1513573(100291967, +), ADediting_1595751(100268623, +), ADediting_1595752(100268630, +), ADediting_1595753(100268633, +), ADediting_1595754(100268657, +), ADediting_1595755(100268672, +), ADediting_1595756(100271389, +), ADediting_1595757(100276078, +), ADediting_1595758(100276115, +), ADediting_1595759(100281820, +), ADediting_1595760(100285753, +),

Top

RNA editing positional annotations for RTCA using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_464chr1_100268585_+intronic
ADediting_465chr1_100268586_+intronic
ADediting_466chr1_100268933_+intronic
ADediting_467chr1_100276042_+intronic
ADediting_468chr1_100276071_+intronic
ADediting_469chr1_100276423_+intronic
ADediting_470chr1_100276424_+intronic
ADediting_471chr1_100276491_+intronic
ADediting_472chr1_100276556_+intronic
ADediting_473chr1_100276659_+intronic
ADediting_474chr1_100280793_+intronic
ADediting_475chr1_100280800_+intronic
ADediting_476chr1_100280807_+intronic
ADediting_477chr1_100280929_+intronic
ADediting_478chr1_100280934_+intronic
ADediting_479chr1_100280964_+intronic
ADediting_480chr1_100280984_+intronic
ADediting_481chr1_100280997_+intronic
ADediting_482chr1_100281743_+intronic
ADediting_483chr1_100281765_+intronic
ADediting_484chr1_100281773_+intronic
ADediting_485chr1_100281780_+intronic
ADediting_486chr1_100281842_+intronic
ADediting_487chr1_100281913_+intronic
ADediting_488chr1_100281925_+intronic
ADediting_489chr1_100281968_+intronic
ADediting_490chr1_100283839_+intronic
ADediting_491chr1_100283841_+intronic
ADediting_492chr1_100283856_+intronic
ADediting_493chr1_100283897_+intronic
ADediting_494chr1_100284603_+intronic
ADediting_495chr1_100284656_+intronic
ADediting_496chr1_100284659_+intronic
ADediting_497chr1_100286190_+intronic
ADediting_498chr1_100286197_+intronic
ADediting_499chr1_100286203_+intronic
ADediting_500chr1_100286307_+intronic
ADediting_501chr1_100286333_+intronic
ADediting_502chr1_100286339_+intronic
ADediting_503chr1_100286343_+intronic
ADediting_504chr1_100287887_+intronic
ADediting_505chr1_100287893_+intronic
ADediting_506chr1_100287894_+intronic
ADediting_507chr1_100287927_+intronic
ADediting_508chr1_100288923_+intronic
ADediting_509chr1_100290326_+intronic
ADediting_510chr1_100290335_+intronic
ADediting_511chr1_100290347_+intronic
ADediting_512chr1_100290358_+intronic
ADediting_513chr1_100290396_+intronic
ADediting_514chr1_100290493_+intronic
ADediting_515chr1_100290497_+intronic
ADediting_516chr1_100290500_+intronic
ADediting_517chr1_100290529_+intronic
ADediting_518chr1_100290533_+intronic
ADediting_519chr1_100290542_+intronic
ADediting_520chr1_100290561_+intronic
ADediting_521chr1_100290619_+intronic
ADediting_522chr1_100290623_+intronic
ADediting_523chr1_100290627_+intronic
ADediting_524chr1_100290672_+intronic
ADediting_525chr1_100290687_+intronic
ADediting_526chr1_100290691_+intronic
ADediting_527chr1_100290695_+intronic
ADediting_528chr1_100290753_+intronic
ADediting_529chr1_100292027_+UTR3
ADediting_530chr1_100292028_+UTR3
ADediting_531chr1_100292031_+UTR3
ADediting_532chr1_100292032_+UTR3
ADediting_533chr1_100292103_+UTR3
ADediting_534chr1_100292122_+UTR3
ADediting_535chr1_100292327_+UTR3
ADediting_536chr1_100292335_+UTR3
ADediting_537chr1_100292343_+UTR3
ADediting_538chr1_100292347_+UTR3
ADediting_539chr1_100292367_+UTR3
ADediting_540chr1_100292372_+UTR3
ADediting_541chr1_100292420_+UTR3
ADediting_542chr1_100292432_+UTR3
ADediting_543chr1_100292448_+UTR3
ADediting_544chr1_100292464_+UTR3
ADediting_1513552chr1_100282855_+intronic
ADediting_1513553chr1_100282949_+intronic
ADediting_1513554chr1_100283006_+intronic
ADediting_1513555chr1_100283011_+intronic
ADediting_1513556chr1_100283032_+intronic
ADediting_1513557chr1_100283060_+intronic
ADediting_1513558chr1_100283424_+intronic
ADediting_1513559chr1_100284807_+intronic
ADediting_1513560chr1_100284812_+intronic
ADediting_1513561chr1_100284836_+intronic
ADediting_1513562chr1_100284850_+intronic
ADediting_1513563chr1_100288659_+intronic
ADediting_1513564chr1_100288916_+intronic
ADediting_1513565chr1_100288940_+intronic
ADediting_1513566chr1_100288952_+intronic
ADediting_1513567chr1_100288964_+intronic
ADediting_1513568chr1_100289029_+intronic
ADediting_1513569chr1_100290346_+intronic
ADediting_1513570chr1_100290668_+intronic
ADediting_1513571chr1_100290707_+intronic
ADediting_1513572chr1_100290748_+intronic
ADediting_1513573chr1_100291967_+UTR3
ADediting_1595751chr1_100268623_+intronic
ADediting_1595752chr1_100268630_+intronic
ADediting_1595753chr1_100268633_+intronic
ADediting_1595754chr1_100268657_+intronic
ADediting_1595755chr1_100268672_+intronic
ADediting_1595756chr1_100271389_+intronic
ADediting_1595757chr1_100276078_+intronic
ADediting_1595758chr1_100276115_+intronic
ADediting_1595759chr1_100281820_+intronic
ADediting_1595760chr1_100285753_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_464chr1_100268585_+SINEAluName=AluJo
ADediting_465chr1_100268586_+SINEAluName=AluJo
ADediting_466chr1_100268933_+SINEAluName=AluJb
ADediting_467chr1_100276042_+SINEAluName=AluY
ADediting_468chr1_100276071_+SINEAluName=AluY
ADediting_469chr1_100276423_+SINEAluName=AluSc
ADediting_470chr1_100276424_+SINEAluName=AluSc
ADediting_471chr1_100276491_+SINEAluName=AluSc
ADediting_472chr1_100276556_+SINEAluName=AluSc
ADediting_473chr1_100276659_+SINEAluName=AluSc
ADediting_474chr1_100280793_+SINEAluName=AluJb
ADediting_475chr1_100280800_+SINEAluName=AluJb
ADediting_476chr1_100280807_+SINEAluName=AluJb
ADediting_477chr1_100280929_+SINEAluName=AluJb
ADediting_478chr1_100280934_+SINEAluName=AluJb
ADediting_479chr1_100280964_+SINEAluName=AluJb
ADediting_480chr1_100280984_+SINEAluName=AluJb
ADediting_481chr1_100280997_+SINEAluName=AluJb
ADediting_482chr1_100281743_+SINEAluName=AluSz
ADediting_483chr1_100281765_+SINEAluName=AluSz
ADediting_484chr1_100281773_+SINEAluName=AluSz
ADediting_485chr1_100281780_+SINEAluName=AluSz
ADediting_486chr1_100281842_+SINEAluName=AluSz
ADediting_487chr1_100281913_+SINEAluName=AluSz
ADediting_488chr1_100281925_+SINEAluName=AluSz
ADediting_489chr1_100281968_+SINEAluName=AluSz
ADediting_490chr1_100283839_+SINEAluName=FLAM_C
ADediting_491chr1_100283841_+SINEAluName=FLAM_C
ADediting_492chr1_100283856_+SINEAluName=FLAM_C
ADediting_493chr1_100283897_+SINEAluName=FLAM_C
ADediting_494chr1_100284603_+SINEAluName=AluSz6
ADediting_495chr1_100284656_+SINEAluName=AluSz6
ADediting_496chr1_100284659_+SINEAluName=AluSz6
ADediting_497chr1_100286190_+SINEAluName=AluYm1
ADediting_498chr1_100286197_+SINEAluName=AluYm1
ADediting_499chr1_100286203_+SINEAluName=AluYm1
ADediting_500chr1_100286307_+SINEAluName=AluYm1
ADediting_501chr1_100286333_+SINEAluName=AluYm1
ADediting_502chr1_100286339_+SINEAluName=AluYm1
ADediting_503chr1_100286343_+SINEAluName=AluYm1
ADediting_504chr1_100287887_+SINEAluName=AluSx
ADediting_505chr1_100287893_+SINEAluName=AluSx
ADediting_506chr1_100287894_+SINEAluName=AluSx
ADediting_507chr1_100287927_+SINEAluName=AluSx
ADediting_508chr1_100288923_+SINEAluName=AluSz6
ADediting_509chr1_100290326_+SINEAluName=FLAM_C
ADediting_510chr1_100290335_+SINEAluName=FLAM_C
ADediting_511chr1_100290347_+SINEAluName=FLAM_C
ADediting_512chr1_100290358_+SINEAluName=FLAM_C
ADediting_513chr1_100290396_+SINEAluName=FLAM_C
ADediting_514chr1_100290493_+SINEAluName=AluJb
ADediting_515chr1_100290497_+SINEAluName=AluJb
ADediting_516chr1_100290500_+SINEAluName=AluJb
ADediting_517chr1_100290529_+SINEAluName=AluJb
ADediting_518chr1_100290533_+SINEAluName=AluJb
ADediting_519chr1_100290542_+SINEAluName=AluJb
ADediting_520chr1_100290561_+SINEAluName=AluJb
ADediting_521chr1_100290619_+SINEAluName=AluJb
ADediting_522chr1_100290623_+SINEAluName=AluJb
ADediting_523chr1_100290627_+SINEAluName=AluJb
ADediting_524chr1_100290672_+SINEAluName=AluJb
ADediting_525chr1_100290687_+SINEAluName=AluJb
ADediting_526chr1_100290691_+SINEAluName=AluJb
ADediting_527chr1_100290695_+SINEAluName=AluJb
ADediting_528chr1_100290753_+SINEAluName=AluJb
ADediting_529chr1_100292027_+SINEAluName=AluSg
ADediting_530chr1_100292028_+SINEAluName=AluSg
ADediting_531chr1_100292031_+SINEAluName=AluSg
ADediting_532chr1_100292032_+SINEAluName=AluSg
ADediting_533chr1_100292103_+SINEAluName=AluSg
ADediting_534chr1_100292122_+SINEAluName=AluSg
ADediting_535chr1_100292327_+SINEAluName=AluSc
ADediting_536chr1_100292335_+SINEAluName=AluSc
ADediting_537chr1_100292343_+SINEAluName=AluSc
ADediting_538chr1_100292347_+SINEAluName=AluSc
ADediting_539chr1_100292367_+SINEAluName=AluSc
ADediting_540chr1_100292372_+SINEAluName=AluSc
ADediting_541chr1_100292420_+SINEAluName=AluSc
ADediting_542chr1_100292432_+SINEAluName=AluSc
ADediting_543chr1_100292448_+SINEAluName=AluSc
ADediting_544chr1_100292464_+SINEAluName=AluSc
ADediting_1513552chr1_100282855_+SINEAluName=AluSz
ADediting_1513553chr1_100282949_+SINEAluName=AluSz
ADediting_1513554chr1_100283006_+SINEAluName=AluSz
ADediting_1513555chr1_100283011_+SINEAluName=AluSz
ADediting_1513556chr1_100283032_+SINEAluName=AluSz
ADediting_1513557chr1_100283060_+SINEAluName=AluSz
ADediting_1513558chr1_100283424_+SINEAluName=AluSz
ADediting_1513559chr1_100284807_+SINEAluName=FLAM_C
ADediting_1513560chr1_100284812_+SINEAluName=FLAM_C
ADediting_1513561chr1_100284836_+SINEAluName=FLAM_C
ADediting_1513562chr1_100284850_+SINEAluName=FLAM_C
ADediting_1513563chr1_100288659_+SINEAluName=AluJo
ADediting_1513564chr1_100288916_+SINEAluName=AluSz6
ADediting_1513565chr1_100288940_+SINEAluName=AluSz6
ADediting_1513566chr1_100288952_+SINEAluName=AluSz6
ADediting_1513567chr1_100288964_+SINEAluName=AluSz6
ADediting_1513568chr1_100289029_+SINEAluName=AluSz6
ADediting_1513569chr1_100290346_+SINEAluName=FLAM_C
ADediting_1513570chr1_100290668_+SINEAluName=AluJb
ADediting_1513571chr1_100290707_+SINEAluName=AluJb
ADediting_1513572chr1_100290748_+SINEAluName=AluJb
ADediting_1513573chr1_100291967_+SINEAluName=AluSg
ADediting_1595751chr1_100268623_+SINEAluName=AluJo
ADediting_1595752chr1_100268630_+SINEAluName=AluJo
ADediting_1595753chr1_100268633_+SINEAluName=AluJo
ADediting_1595754chr1_100268657_+SINEAluName=AluJo
ADediting_1595755chr1_100268672_+SINEAluName=AluJo
ADediting_1595756chr1_100271389_+SINEAluName=AluJb
ADediting_1595757chr1_100276078_+SINEAluName=AluY
ADediting_1595758chr1_100276115_+SINEAluName=AluY
ADediting_1595759chr1_100281820_+SINEAluName=AluSz
ADediting_1595760chr1_100285753_+SINEAluName=AluJr4

Top

RNA A-to-I editing events in the alternative splicing sites for RTCA

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for RTCA

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot
boxplot
boxplot
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
Soverview
Soverview
Soverview
Soverview
Soverview

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

Top

Protein coding region RNA A-to-I editings for RTCA

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for RTCA

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1513573chr1_100291967_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4486chr11002919651002919717mer-m8100291956100291972145-18.64
ADediting_535chr1_100292327_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-340-3pchr11002923211002923288mer-1a100292307100292328146-18.22
ADediting_535chr1_100292327_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6827-3pchr11002923211002923288mer-1a100292308100292328140-14.67
ADediting_538chr1_100292347_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4299chr11002923401002923467mer-m8100292327100292347158-23.95
ADediting_538chr1_100292347_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-490-3pchr11002923431002923497mer-m8100292329100292350143-20
ADediting_539chr1_100292367_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-3672chr11002923651002923717mer-m8100292351100292372141-14.4
ADediting_539chr1_100292367_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6529-3pchr11002923601002923667mer-m8100292345100292367156-18.52
ADediting_539chr1_100292367_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6864-3pchr11002923651002923717mer-m8100292349100292372146-19.98
ADediting_539chr1_100292367_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6889-3pchr11002923601002923667mer-m8100292347100292367156-19.92
ADediting_539chr1_100292367_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-873-3pchr11002923641002923718mer-1a100292351100292371141-14.93
ADediting_540chr1_100292372_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4537chr11002923691002923768mer-1a100292354100292376151-25.12
ADediting_541chr1_100292420_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6089chr11002924181002924247mer-m8100292401100292425163-35.47
ADediting_542chr1_100292432_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4691-3pchr11002924291002924357mer-m8100292409100292436154-27.29
ADediting_543chr1_100292448_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6720-3pchr11002924421002924487mer-m8100292428100292449152-25.83
ADediting_544chr1_100292464_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-137-5pchr11002924571002924637mer-m8100292442100292464145-20.45

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1513573chr1_100291967_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-1262chr11002919641002919707mer-m8100291950100291971140-17.68
ADediting_1513573chr1_100291967_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4701-3pchr11002919641002919707mer-m8100291951100291971149-20.54
ADediting_1513573chr1_100291967_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6736-5pchr11002919641002919707mer-m8100291951100291971146-19.88
ADediting_1513573chr1_100291967_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6776-5pchr11002919651002919717mer-m8100291953100291972152-24.18
ADediting_531chr1_100292031_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-219b-3pchr11002920281002920347mer-m8100292015100292035153-15.53
ADediting_531chr1_100292031_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-302fchr11002920271002920337mer-m8100292018100292034145-8.09
ADediting_532chr1_100292032_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-219b-3pchr11002920281002920347mer-m8100292015100292035153-15.53
ADediting_532chr1_100292032_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-302fchr11002920271002920337mer-m8100292018100292034145-8.09
ADediting_533chr1_100292103_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-593-3pchr11002921021002921087mer-1a100292090100292108140-19.02
ADediting_534chr1_100292122_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-5583-3pchr11002921171002921237mer-m8100292102100292124147-9.78
ADediting_535chr1_100292327_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-3664-5pchr11002923241002923307mer-m8100292310100292331153-15.65
ADediting_535chr1_100292327_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4522chr11002923251002923317mer-m8100292312100292332148-12.83
ADediting_535chr1_100292327_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6888-3pchr11002923221002923287mer-m8100292309100292329151-14.42
ADediting_536chr1_100292335_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6864-3pchr11002923281002923347mer-m8100292314100292335153-17.84
ADediting_536chr1_100292335_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-759chr11002923331002923397mer-m8100292320100292340145-15.6
ADediting_539chr1_100292367_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-5186chr11002923641002923718mer-1a100292351100292371140-10.69
ADediting_540chr1_100292372_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-3160-3pchr11002923691002923768mer-1a100292355100292376152-17.9
ADediting_541chr1_100292420_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-3929chr11002924171002924237mer-m8100292402100292424149-21.61
ADediting_541chr1_100292420_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4478chr11002924171002924237mer-m8100292407100292424154-25.63
ADediting_541chr1_100292420_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-4649-3pchr11002924141002924207mer-m8100292402100292421141-13.75
ADediting_541chr1_100292420_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-485-5pchr11002924181002924247mer-m8100292404100292425156-19.12
ADediting_541chr1_100292420_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-6884-5pchr11002924181002924247mer-m8100292403100292425152-20.35
ADediting_541chr1_100292420_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-7160-5pchr11002924151002924217mer-m8100292402100292422146-16.5
ADediting_542chr1_100292432_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-5690chr11002924291002924357mer-m8100292416100292436145-16.75
ADediting_543chr1_100292448_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-1271-3pchr11002924421002924487mer-m8100292430100292449151-22.68
ADediting_543chr1_100292448_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-550a-3-5pchr11002924421002924487mer-m8100292431100292449144-18.68
ADediting_543chr1_100292448_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-550a-5pchr11002924421002924487mer-m8100292430100292449149-20.26
ADediting_544chr1_100292464_+ENSG00000137996.12ENST00000370128.8RTCA-203hsa-miR-1298-3pchr11002924601002924678mer-1a100292447100292467142-11.81

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for RTCA

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000370128.8protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1513573ENST00000370128.8chr1_100291967_+1733-753.70-753.50-770.90
ADediting_529ENST00000370128.8chr1_100292027_+1793-753.80-753.50-770.90
ADediting_530ENST00000370128.8chr1_100292028_+1794-756.20-753.50-770.90
ADediting_531ENST00000370128.8chr1_100292031_+1797-753.20-753.50-770.90
ADediting_532ENST00000370128.8chr1_100292032_+1798-756.90-753.50-770.90
ADediting_533ENST00000370128.8chr1_100292103_+1869-752.70-753.50-770.90
ADediting_534ENST00000370128.8chr1_100292122_+1888-753.50-753.50-770.90
ADediting_535ENST00000370128.8chr1_100292327_+2093-752.80-753.50-770.90
ADediting_536ENST00000370128.8chr1_100292335_+2101-753.80-753.50-770.90
ADediting_537ENST00000370128.8chr1_100292343_+2109-753.50-753.50-770.90
ADediting_538ENST00000370128.8chr1_100292347_+2113-755.80-753.50-770.90
ADediting_539ENST00000370128.8chr1_100292367_+2133-753.50-753.50-770.90
ADediting_540ENST00000370128.8chr1_100292372_+2138-754.00-753.50-770.90
ADediting_541ENST00000370128.8chr1_100292420_+2186-756.50-753.50-770.90
ADediting_542ENST00000370128.8chr1_100292432_+2198-757.10-753.50-770.90
ADediting_543ENST00000370128.8chr1_100292448_+2214-753.40-753.50-770.90
ADediting_544ENST00000370128.8chr1_100292464_+2230-755.80-753.50-770.90

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for RTCA

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_492chr1_100283856_+0.431622721936093-0.0448241573201960.0269603076623179-0.1256476590347743.10932525223283e-120.382413371234088
DLPFCADediting_501chr1_100286333_+0.6694655525813860.02433998207512820.139531332615735-0.08410956670284641.22524385141797e-160.447068255632476
DLPFCADediting_503chr1_100286343_+0.3820831613949960.049813933350550.0722106861777706-0.1022527560154632.51536001853049e-220.51424708112575
CERADediting_504chr1_100287887_+0.0008178130425068380.2704095551149224.93295474461166e-060.3631687045426590.4560909106034560.0613090201647707
CERADediting_507chr1_100287927_+0.008454794260041410.2143006970046757.72205603724864e-050.317036125446440.9316896511314730.00705789774416422
DLPFCADediting_512chr1_100290358_+1.07351451431609e-070.2962017773700142.5597010735344e-080.309745476539610.8959817368140590.00745549450530451
DLPFCADediting_514chr1_100290493_+1.7269441621189e-100.3523103496016197.5077515187258e-120.3760695324630670.4302577364057820.0449569890905289
TCXADediting_514chr1_100290493_+7.89956962347963e-050.3166225059528136.48864350714369e-050.3201834131108690.0706133613274767-0.148042913818279
DLPFCADediting_516chr1_100290500_+9.90094730695697e-140.4059868358133549.66378538051292e-160.4349796496083540.07350652290082660.101793622508331
TCXADediting_516chr1_100290500_+5.54526583668986e-070.3953046275602483.86254807779806e-060.3669408880816030.0948557304698178-0.136883558960127
CERADediting_517chr1_100290529_+0.03723310282656270.1702727329429415.74523495021087e-080.4254028446783920.04234361437890920.165996004277185
CERADediting_518chr1_100290533_+0.04908996846828870.1609682015685347.44482867281208e-050.3177002342555990.9860460916033870.00144005958861629
DLPFCADediting_519chr1_100290542_+7.87155827640586e-140.4074911380546218.43340041150511e-150.4217584781248530.02724911369114340.125413158099901
DLPFCADediting_524chr1_100290672_+3.6263245290105e-080.306517619607783.91246335200699e-100.3457756767466660.001380216214629440.180906692333441
CERADediting_525chr1_100290687_+0.02930471296887670.1780096766418660.0001659851818940690.3027642249332690.5998476697108310.0431762150220749
CERADediting_526chr1_100290691_+0.007975202507345230.215871683481189.57547819735442e-060.352692677963270.07215452002620330.147248107749815
CERADediting_527chr1_100290695_+0.005686212600712440.2247733171143291.48281857275582e-070.4131720621430180.1416069165997040.120581758278148

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.50321424467181e-390.6547387435499331.69165057333191e-190.4826926649010553.94477755164461e-240.532794638759655
AC2.95353711989729e-950.9072378905543611.01255220805747e-580.8072519673531881.95417375480089e-130.442919269104675
PCC6.46191616224939e-500.8305081435837675.59197909241006e-550.8518672514429050.06630097730473580.133157783446052
CER2.48828601742254e-340.7977668743508729.36854412741251e-130.5405189763118140.4063905696578030.068282669985856
TCX1.02904609265132e-480.8759698875803931.43955351446553e-240.7128219851308460.8565668114911030.014881537479152
FP2.00388746074687e-150.5493893116378121.4385524044589e-200.6236165589868330.37869969235249-0.0663757104073149
IFG1.91231047330622e-050.745317531476410.002952298235040170.5696845102473450.589120724336202-0.113481988587426
PG2.18183538146945e-570.8663937347400611.89150908687079e-340.7469632546964950.380537326890119-0.0646665229816936
STG8.73280625742469e-210.8110055792594842.76953300606659e-160.7484099020395530.477948295468867-0.0784808050168512

Top

Relation with AD stages for RTCA

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_492chr1_100283856_+0.00021616738817729-0.348781050659859
TCXADediting_492chr1_100283856_+0.000485657408596029-0.333058574491985

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
STG0.00251606627507126-0.325511452311568

Top

RelatedDrugs for RTCA

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RTCA

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource