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	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene

Gene summary for MKNK1

Gene summary

Gene information	Gene symbol	MKNK1
	Gene ID	8569
	Gene name	MAPK interacting serine/threonine kinase 1
	Synonyms	MNK1
	Cytomap	1p33
	Type of gene	protein-coding
	Description	MAP kinase-interacting serine/threonine-protein kinase 1MAP kinase interacting serine/threonine kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1
	Modification date	20200327
	UniProtAcc	Q9BUB5,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MKNK1	GO:0006468	protein phosphorylation	9155018
MKNK1	GO:0018105	peptidyl-serine phosphorylation	17130135
MKNK1	GO:0035556	intracellular signal transduction	9155018

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RNA A-to-I events for MKNK1

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_120944(46572337, -), ADediting_120945(46572350, -), ADediting_120946(46572351, -), ADediting_120947(46572423, -), ADediting_120948(46577277, -), ADediting_120949(46577313, -), ADediting_120950(46577316, -), ADediting_120951(46577398, -), ADediting_120952(46577442, -), ADediting_120953(46578662, -), ADediting_120954(46578672, -), ADediting_120955(46578689, -), ADediting_120956(46578934, -), ADediting_120957(46578937, -), ADediting_120958(46579048, -), ADediting_120959(46586152, -), ADediting_120960(46586336, -), ADediting_120961(46586834, -), ADediting_120962(46586841, -), ADediting_120963(46586842, -), ADediting_120964(46586845, -), ADediting_120965(46586847, -), ADediting_120966(46586859, -), ADediting_120967(46586874, -), ADediting_120968(46586880, -), ADediting_120969(46586893, -), ADediting_120970(46586904, -), ADediting_120971(46586905, -), ADediting_120972(46586913, -), ADediting_120973(46586914, -), ADediting_120974(46586916, -), ADediting_120975(46586919, -), ADediting_120976(46586923, -), ADediting_120977(46586929, -), ADediting_120978(46586936, -), ADediting_120979(46586940, -), ADediting_120980(46586946, -), ADediting_120981(46586956, -), ADediting_120982(46586972, -), ADediting_120983(46586975, -), ADediting_120984(46586976, -), ADediting_120985(46586977, -), ADediting_120986(46586982, -), ADediting_120987(46586985, -), ADediting_120988(46586986, -), ADediting_120989(46586989, -), ADediting_120990(46586992, -), ADediting_120991(46587003, -), ADediting_120992(46587004, -), ADediting_120993(46587011, -), ADediting_120994(46587013, -), ADediting_120995(46587014, -), ADediting_120996(46587023, -), ADediting_120997(46587026, -), ADediting_120998(46587028, -), ADediting_120999(46587037, -), ADediting_121000(46587042, -), ADediting_121001(46587047, -), ADediting_121002(46587056, -), ADediting_121003(46587060, -), ADediting_121004(46587061, -), ADediting_121005(46587074, -), ADediting_121006(46587077, -), ADediting_121007(46587082, -), ADediting_121008(46587083, -), ADediting_121009(46587091, -), ADediting_121010(46587099, -), ADediting_121011(46587116, -), ADediting_121012(46587545, -), ADediting_121013(46587552, -), ADediting_121014(46587561, -), ADediting_121015(46587573, -), ADediting_121016(46587574, -), ADediting_121017(46587575, -), ADediting_121018(46587601, -), ADediting_121019(46587606, -), ADediting_121020(46587614, -), ADediting_121021(46587645, -), ADediting_121022(46587652, -), ADediting_121023(46587655, -), ADediting_121024(46587689, -), ADediting_121025(46587693, -), ADediting_121026(46587695, -), ADediting_121027(46587705, -), ADediting_121028(46587717, -), ADediting_121029(46587730, -), ADediting_121030(46587731, -), ADediting_121031(46587734, -), ADediting_121032(46587735, -), ADediting_121033(46587754, -), ADediting_121034(46587765, -), ADediting_121035(46587778, -), ADediting_121036(46587804, -), ADediting_121037(46587816, -), ADediting_121038(46588563, -), ADediting_121039(46588564, -), ADediting_121040(46588640, -), ADediting_121041(46588695, -), ADediting_121042(46588697, -), ADediting_121043(46591399, -), ADediting_121044(46591678, -), ADediting_121045(46591682, -), ADediting_121046(46591983, -), ADediting_121047(46592005, -), ADediting_121048(46592068, -), ADediting_121049(46592091, -), ADediting_121050(46592096, -), ADediting_121051(46592127, -), ADediting_121052(46592128, -), ADediting_121053(46592157, -), ADediting_121054(46592158, -), ADediting_121055(46592177, -), ADediting_121056(46592183, -), ADediting_121057(46592226, -), ADediting_121058(46592234, -), ADediting_121059(46592238, -), ADediting_121060(46593251, -), ADediting_121061(46593264, -), ADediting_121062(46593266, -), ADediting_121063(46593271, -), ADediting_121064(46593275, -), ADediting_121065(46593288, -), ADediting_121066(46593295, -), ADediting_121067(46593296, -), ADediting_121068(46593309, -), ADediting_121069(46593310, -), ADediting_121070(46593314, -), ADediting_121071(46593327, -), ADediting_121072(46593331, -), ADediting_121073(46593337, -), ADediting_121074(46593347, -), ADediting_121075(46593355, -), ADediting_121076(46593358, -), ADediting_121077(46593359, -), ADediting_121078(46593367, -), ADediting_121079(46593368, -), ADediting_121080(46593381, -), ADediting_121081(46593392, -), ADediting_121082(46593393, -), ADediting_121083(46593396, -), ADediting_121084(46593596, -), ADediting_121085(46593602, -), ADediting_121086(46593614, -), ADediting_121087(46593641, -), ADediting_121088(46593642, -), ADediting_121089(46593654, -), ADediting_121090(46593655, -), ADediting_121091(46593667, -), ADediting_121092(46593671, -), ADediting_121093(46593692, -), ADediting_121094(46593695, -), ADediting_121095(46593707, -), ADediting_121096(46593712, -), ADediting_121097(46593716, -), ADediting_121098(46593724, -), ADediting_121099(46593732, -), ADediting_121100(46593734, -), ADediting_121101(46593737, -), ADediting_121102(46593744, -), ADediting_121103(46593756, -), ADediting_121104(46593769, -), ADediting_121105(46593773, -), ADediting_121106(46593774, -), ADediting_121107(46593780, -), ADediting_121108(46593793, -), ADediting_121109(46593794, -), ADediting_121110(46593799, -), ADediting_121111(46593809, -), ADediting_121112(46593830, -), ADediting_121113(46593850, -), ADediting_121114(46594732, -), ADediting_121115(46594736, -), ADediting_121116(46594738, -), ADediting_121117(46594743, -), ADediting_121118(46594750, -), ADediting_121119(46594760, -), ADediting_121120(46594803, -), ADediting_121121(46594828, -), ADediting_121122(46594839, -), ADediting_121123(46594900, -), ADediting_121124(46594901, -), ADediting_121125(46594904, -), ADediting_121126(46594905, -), ADediting_121127(46594925, -), ADediting_121128(46595814, -), ADediting_121129(46595819, -), ADediting_121130(46595820, -), ADediting_121131(46595854, -), ADediting_121132(46595975, -), ADediting_121133(46596020, -), ADediting_121134(46596021, -), ADediting_121135(46596023, -), ADediting_121136(46601189, -), ADediting_121137(46601190, -), ADediting_121138(46601198, -), ADediting_121139(46602209, -), ADediting_121140(46602365, -), ADediting_121141(46602368, -), ADediting_121142(46602374, -), ADediting_121143(46605694, -), ADediting_121144(46605697, -), ADediting_121145(46605708, -), ADediting_121146(46605720, -), ADediting_121147(46605730, -), ADediting_121148(46605734, -), ADediting_121149(46605743, -), ADediting_121150(46605744, -), ADediting_121151(46605757, -), ADediting_121152(46605770, -), ADediting_121153(46605801, -), ADediting_121154(46605893, -), ADediting_121155(46607115, -), ADediting_121156(46607182, -), ADediting_121157(46607260, -), ADediting_1520356(46571434, -), ADediting_1520357(46571447, -), ADediting_1520358(46571537, -), ADediting_1520359(46571541, -), ADediting_1520360(46588643, -), ADediting_1520361(46588683, -), ADediting_1520362(46592236, -), ADediting_1520363(46593747, -), ADediting_1520364(46594918, -), ADediting_1520365(46594961, -), ADediting_1520366(46595828, -), ADediting_1520367(46595849, -), ADediting_1520368(46595873, -), ADediting_1520369(46595880, -), ADediting_1520370(46595921, -), ADediting_1520371(46595923, -), ADediting_1520372(46595924, -), ADediting_1520373(46598650, -), ADediting_1520374(46598656, -), ADediting_1520375(46598831, -), ADediting_1520376(46598997, -), ADediting_1520377(46599058, -), ADediting_1520378(46601013, -), ADediting_1520379(46602207, -), ADediting_1520380(46605727, -), ADediting_1520381(46605738, -), ADediting_1520382(46605752, -), ADediting_1520383(46605762, -), ADediting_1520384(46605766, -), ADediting_1520385(46605821, -), ADediting_1520386(46607190, -), ADediting_1520387(46607248, -), ADediting_1520388(46607250, -), ADediting_1520389(46607309, -), ADediting_1520390(46610423, -), ADediting_1520391(46610495, -), ADediting_1601086(46593810, -),

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RNA editing positional annotations for MKNK1 using Annovar

Protein coding RNA editing(s).

ADeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
ADediting_121123	chr1_46594900_-	nonsynonymous SNV	ENST00000532110.1	c.A44G	p.N15S	0.0	.	-0.6
ADediting_121124	chr1_46594901_-	nonsynonymous SNV	ENST00000532110.1	c.A43G	p.N15D	0.0	.	0.2
ADediting_121125	chr1_46594904_-	nonsynonymous SNV	ENST00000532110.1	c.A40G	p.S14G	0.0	.	-0.94
ADediting_121126	chr1_46594905_-	synonymous SNV	ENST00000532110.1	c.A39G	p.S13S	.	.	.
ADediting_121127	chr1_46594925_-	nonsynonymous SNV	ENST00000532110.1	c.A19G	p.S7G	0.0	.	-0.67
ADediting_1520356	chr1_46571434_-	nonsynonymous SNV	ENST00000371946.9	c.A563G	p.Q188R	0.047	0.0	-0.11
ADediting_1520356	chr1_46571434_-	nonsynonymous SNV	ENST00000649800.1	c.A599G	p.Q200R	0.047	0.0	-0.11
ADediting_1520357	chr1_46571447_-	nonsynonymous SNV	ENST00000371946.9	c.A550G	p.T184A	0.227	0.0	-0.12
ADediting_1520357	chr1_46571447_-	nonsynonymous SNV	ENST00000649800.1	c.A586G	p.T196A	0.227	0.0	-0.12
ADediting_1520358	chr1_46571537_-	nonsynonymous SNV	ENST00000371946.9	c.A460G	p.K154E	0.74	0.0	-0.08
ADediting_1520358	chr1_46571537_-	nonsynonymous SNV	ENST00000649800.1	c.A496G	p.K166E	0.74	0.0	-0.08
ADediting_1520364	chr1_46594918_-	nonsynonymous SNV	ENST00000532110.1	c.A26G	p.D9G	0.0	.	-1.27

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_120944	chr1_46572337_-	intronic
ADediting_120945	chr1_46572350_-	intronic
ADediting_120946	chr1_46572351_-	intronic
ADediting_120947	chr1_46572423_-	intronic
ADediting_120948	chr1_46577277_-	intronic
ADediting_120949	chr1_46577313_-	intronic
ADediting_120950	chr1_46577316_-	intronic
ADediting_120951	chr1_46577398_-	intronic
ADediting_120952	chr1_46577442_-	intronic
ADediting_120953	chr1_46578662_-	intronic
ADediting_120954	chr1_46578672_-	intronic
ADediting_120955	chr1_46578689_-	intronic
ADediting_120956	chr1_46578934_-	intronic
ADediting_120957	chr1_46578937_-	intronic
ADediting_120958	chr1_46579048_-	intronic
ADediting_120959	chr1_46586152_-	intronic
ADediting_120960	chr1_46586336_-	intronic
ADediting_120961	chr1_46586834_-	intronic
ADediting_120962	chr1_46586841_-	intronic
ADediting_120963	chr1_46586842_-	intronic
ADediting_120964	chr1_46586845_-	intronic
ADediting_120965	chr1_46586847_-	intronic
ADediting_120966	chr1_46586859_-	intronic
ADediting_120967	chr1_46586874_-	intronic
ADediting_120968	chr1_46586880_-	intronic
ADediting_120969	chr1_46586893_-	intronic
ADediting_120970	chr1_46586904_-	intronic
ADediting_120971	chr1_46586905_-	intronic
ADediting_120972	chr1_46586913_-	intronic
ADediting_120973	chr1_46586914_-	intronic
ADediting_120974	chr1_46586916_-	intronic
ADediting_120975	chr1_46586919_-	intronic
ADediting_120976	chr1_46586923_-	intronic
ADediting_120977	chr1_46586929_-	intronic
ADediting_120978	chr1_46586936_-	intronic
ADediting_120979	chr1_46586940_-	intronic
ADediting_120980	chr1_46586946_-	intronic
ADediting_120981	chr1_46586956_-	intronic
ADediting_120982	chr1_46586972_-	intronic
ADediting_120983	chr1_46586975_-	intronic
ADediting_120984	chr1_46586976_-	intronic
ADediting_120985	chr1_46586977_-	intronic
ADediting_120986	chr1_46586982_-	intronic
ADediting_120987	chr1_46586985_-	intronic
ADediting_120988	chr1_46586986_-	intronic
ADediting_120989	chr1_46586989_-	intronic
ADediting_120990	chr1_46586992_-	intronic
ADediting_120991	chr1_46587003_-	intronic
ADediting_120992	chr1_46587004_-	intronic
ADediting_120993	chr1_46587011_-	intronic
ADediting_120994	chr1_46587013_-	intronic
ADediting_120995	chr1_46587014_-	intronic
ADediting_120996	chr1_46587023_-	intronic
ADediting_120997	chr1_46587026_-	intronic
ADediting_120998	chr1_46587028_-	intronic
ADediting_120999	chr1_46587037_-	intronic
ADediting_121000	chr1_46587042_-	intronic
ADediting_121001	chr1_46587047_-	intronic
ADediting_121002	chr1_46587056_-	intronic
ADediting_121003	chr1_46587060_-	intronic
ADediting_121004	chr1_46587061_-	intronic
ADediting_121005	chr1_46587074_-	intronic
ADediting_121006	chr1_46587077_-	intronic
ADediting_121007	chr1_46587082_-	intronic
ADediting_121008	chr1_46587083_-	intronic
ADediting_121009	chr1_46587091_-	intronic
ADediting_121010	chr1_46587099_-	intronic
ADediting_121011	chr1_46587116_-	intronic
ADediting_121012	chr1_46587545_-	intronic
ADediting_121013	chr1_46587552_-	intronic
ADediting_121014	chr1_46587561_-	intronic
ADediting_121015	chr1_46587573_-	intronic
ADediting_121016	chr1_46587574_-	intronic
ADediting_121017	chr1_46587575_-	intronic
ADediting_121018	chr1_46587601_-	intronic
ADediting_121019	chr1_46587606_-	intronic
ADediting_121020	chr1_46587614_-	intronic
ADediting_121021	chr1_46587645_-	intronic
ADediting_121022	chr1_46587652_-	intronic
ADediting_121023	chr1_46587655_-	intronic
ADediting_121024	chr1_46587689_-	intronic
ADediting_121025	chr1_46587693_-	intronic
ADediting_121026	chr1_46587695_-	intronic
ADediting_121027	chr1_46587705_-	intronic
ADediting_121028	chr1_46587717_-	intronic
ADediting_121029	chr1_46587730_-	intronic
ADediting_121030	chr1_46587731_-	intronic
ADediting_121031	chr1_46587734_-	intronic
ADediting_121032	chr1_46587735_-	intronic
ADediting_121033	chr1_46587754_-	intronic
ADediting_121034	chr1_46587765_-	intronic
ADediting_121035	chr1_46587778_-	intronic
ADediting_121036	chr1_46587804_-	intronic
ADediting_121037	chr1_46587816_-	intronic
ADediting_121038	chr1_46588563_-	intronic
ADediting_121039	chr1_46588564_-	intronic
ADediting_121040	chr1_46588640_-	intronic
ADediting_121041	chr1_46588695_-	intronic
ADediting_121042	chr1_46588697_-	intronic
ADediting_121043	chr1_46591399_-	intronic
ADediting_121044	chr1_46591678_-	intronic
ADediting_121045	chr1_46591682_-	intronic
ADediting_121046	chr1_46591983_-	intronic
ADediting_121047	chr1_46592005_-	intronic
ADediting_121048	chr1_46592068_-	intronic
ADediting_121049	chr1_46592091_-	intronic
ADediting_121050	chr1_46592096_-	intronic
ADediting_121051	chr1_46592127_-	intronic
ADediting_121052	chr1_46592128_-	intronic
ADediting_121053	chr1_46592157_-	intronic
ADediting_121054	chr1_46592158_-	intronic
ADediting_121055	chr1_46592177_-	intronic
ADediting_121056	chr1_46592183_-	intronic
ADediting_121057	chr1_46592226_-	intronic
ADediting_121058	chr1_46592234_-	intronic
ADediting_121059	chr1_46592238_-	intronic
ADediting_121060	chr1_46593251_-	intronic
ADediting_121061	chr1_46593264_-	intronic
ADediting_121062	chr1_46593266_-	intronic
ADediting_121063	chr1_46593271_-	intronic
ADediting_121064	chr1_46593275_-	intronic
ADediting_121065	chr1_46593288_-	intronic
ADediting_121066	chr1_46593295_-	intronic
ADediting_121067	chr1_46593296_-	intronic
ADediting_121068	chr1_46593309_-	intronic
ADediting_121069	chr1_46593310_-	intronic
ADediting_121070	chr1_46593314_-	intronic
ADediting_121071	chr1_46593327_-	intronic
ADediting_121072	chr1_46593331_-	intronic
ADediting_121073	chr1_46593337_-	intronic
ADediting_121074	chr1_46593347_-	intronic
ADediting_121075	chr1_46593355_-	intronic
ADediting_121076	chr1_46593358_-	intronic
ADediting_121077	chr1_46593359_-	intronic
ADediting_121078	chr1_46593367_-	intronic
ADediting_121079	chr1_46593368_-	intronic
ADediting_121080	chr1_46593381_-	intronic
ADediting_121081	chr1_46593392_-	intronic
ADediting_121082	chr1_46593393_-	intronic
ADediting_121083	chr1_46593396_-	intronic
ADediting_121084	chr1_46593596_-	intronic
ADediting_121085	chr1_46593602_-	intronic
ADediting_121086	chr1_46593614_-	intronic
ADediting_121087	chr1_46593641_-	intronic
ADediting_121088	chr1_46593642_-	intronic
ADediting_121089	chr1_46593654_-	intronic
ADediting_121090	chr1_46593655_-	intronic
ADediting_121091	chr1_46593667_-	intronic
ADediting_121092	chr1_46593671_-	intronic
ADediting_121093	chr1_46593692_-	intronic
ADediting_121094	chr1_46593695_-	intronic
ADediting_121095	chr1_46593707_-	intronic
ADediting_121096	chr1_46593712_-	intronic
ADediting_121097	chr1_46593716_-	intronic
ADediting_121098	chr1_46593724_-	intronic
ADediting_121099	chr1_46593732_-	intronic
ADediting_121100	chr1_46593734_-	intronic
ADediting_121101	chr1_46593737_-	intronic
ADediting_121102	chr1_46593744_-	intronic
ADediting_121103	chr1_46593756_-	intronic
ADediting_121104	chr1_46593769_-	intronic
ADediting_121105	chr1_46593773_-	intronic
ADediting_121106	chr1_46593774_-	intronic
ADediting_121107	chr1_46593780_-	intronic
ADediting_121108	chr1_46593793_-	intronic
ADediting_121109	chr1_46593794_-	intronic
ADediting_121110	chr1_46593799_-	intronic
ADediting_121111	chr1_46593809_-	intronic
ADediting_121112	chr1_46593830_-	intronic
ADediting_121113	chr1_46593850_-	intronic
ADediting_121114	chr1_46594732_-	intronic
ADediting_121115	chr1_46594736_-	intronic
ADediting_121116	chr1_46594738_-	intronic
ADediting_121117	chr1_46594743_-	intronic
ADediting_121118	chr1_46594750_-	intronic
ADediting_121119	chr1_46594760_-	intronic
ADediting_121120	chr1_46594803_-	intronic
ADediting_121121	chr1_46594828_-	intronic
ADediting_121122	chr1_46594839_-	intronic
ADediting_121123	chr1_46594900_-	exonic
ADediting_121124	chr1_46594901_-	exonic
ADediting_121125	chr1_46594904_-	exonic
ADediting_121126	chr1_46594905_-	exonic
ADediting_121127	chr1_46594925_-	exonic
ADediting_121128	chr1_46595814_-	intronic
ADediting_121129	chr1_46595819_-	intronic
ADediting_121130	chr1_46595820_-	intronic
ADediting_121131	chr1_46595854_-	intronic
ADediting_121132	chr1_46595975_-	intronic
ADediting_121133	chr1_46596020_-	intronic
ADediting_121134	chr1_46596021_-	intronic
ADediting_121135	chr1_46596023_-	intronic
ADediting_121136	chr1_46601189_-	intronic
ADediting_121137	chr1_46601190_-	intronic
ADediting_121138	chr1_46601198_-	intronic
ADediting_121139	chr1_46602209_-	intronic
ADediting_121140	chr1_46602365_-	intronic
ADediting_121141	chr1_46602368_-	intronic
ADediting_121142	chr1_46602374_-	intronic
ADediting_121143	chr1_46605694_-	intronic
ADediting_121144	chr1_46605697_-	intronic
ADediting_121145	chr1_46605708_-	intronic
ADediting_121146	chr1_46605720_-	intronic
ADediting_121147	chr1_46605730_-	intronic
ADediting_121148	chr1_46605734_-	intronic
ADediting_121149	chr1_46605743_-	intronic
ADediting_121150	chr1_46605744_-	intronic
ADediting_121151	chr1_46605757_-	intronic
ADediting_121152	chr1_46605770_-	intronic
ADediting_121153	chr1_46605801_-	intronic
ADediting_121154	chr1_46605893_-	intronic
ADediting_121155	chr1_46607115_-	intronic
ADediting_121156	chr1_46607182_-	intronic
ADediting_121157	chr1_46607260_-	intronic
ADediting_1520356	chr1_46571434_-	exonic
ADediting_1520357	chr1_46571447_-	exonic
ADediting_1520358	chr1_46571537_-	exonic
ADediting_1520359	chr1_46571541_-	splicing
ADediting_1520360	chr1_46588643_-	intronic
ADediting_1520361	chr1_46588683_-	intronic
ADediting_1520362	chr1_46592236_-	intronic
ADediting_1520363	chr1_46593747_-	intronic
ADediting_1520364	chr1_46594918_-	exonic
ADediting_1520365	chr1_46594961_-	UTR5
ADediting_1520366	chr1_46595828_-	intronic
ADediting_1520367	chr1_46595849_-	intronic
ADediting_1520368	chr1_46595873_-	intronic
ADediting_1520369	chr1_46595880_-	intronic
ADediting_1520370	chr1_46595921_-	intronic
ADediting_1520371	chr1_46595923_-	intronic
ADediting_1520372	chr1_46595924_-	intronic
ADediting_1520373	chr1_46598650_-	intronic
ADediting_1520374	chr1_46598656_-	intronic
ADediting_1520375	chr1_46598831_-	intronic
ADediting_1520376	chr1_46598997_-	intronic
ADediting_1520377	chr1_46599058_-	intronic
ADediting_1520378	chr1_46601013_-	intronic
ADediting_1520379	chr1_46602207_-	intronic
ADediting_1520380	chr1_46605727_-	intronic
ADediting_1520381	chr1_46605738_-	intronic
ADediting_1520382	chr1_46605752_-	intronic
ADediting_1520383	chr1_46605762_-	intronic
ADediting_1520384	chr1_46605766_-	intronic
ADediting_1520385	chr1_46605821_-	intronic
ADediting_1520386	chr1_46607190_-	intronic
ADediting_1520387	chr1_46607248_-	intronic
ADediting_1520388	chr1_46607250_-	intronic
ADediting_1520389	chr1_46607309_-	intronic
ADediting_1520390	chr1_46610423_-	intronic
ADediting_1520391	chr1_46610495_-	intronic
ADediting_1601086	chr1_46593810_-	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_120944	chr1_46572337_-	SINE	Alu	Name=AluSz
ADediting_120945	chr1_46572350_-	SINE	Alu	Name=AluSz
ADediting_120946	chr1_46572351_-	SINE	Alu	Name=AluSz
ADediting_120947	chr1_46572423_-	SINE	Alu	Name=AluSz
ADediting_120948	chr1_46577277_-	SINE	Alu	Name=AluSx1
ADediting_120949	chr1_46577313_-	SINE	Alu	Name=AluSx1
ADediting_120950	chr1_46577316_-	SINE	Alu	Name=AluSx1
ADediting_120951	chr1_46577398_-	SINE	Alu	Name=AluSx1
ADediting_120952	chr1_46577442_-	SINE	Alu	Name=AluSx1
ADediting_120953	chr1_46578662_-	SINE	Alu	Name=AluSx
ADediting_120954	chr1_46578672_-	SINE	Alu	Name=AluSx
ADediting_120955	chr1_46578689_-	SINE	Alu	Name=AluSx
ADediting_120956	chr1_46578934_-	SINE	Alu	Name=AluSx
ADediting_120957	chr1_46578937_-	SINE	Alu	Name=AluSx
ADediting_120958	chr1_46579048_-	SINE	Alu	Name=AluSx
ADediting_120961	chr1_46586834_-	SINE	Alu	Name=AluSx3
ADediting_120962	chr1_46586841_-	SINE	Alu	Name=AluSx3
ADediting_120963	chr1_46586842_-	SINE	Alu	Name=AluSx3
ADediting_120964	chr1_46586845_-	SINE	Alu	Name=AluSx3
ADediting_120965	chr1_46586847_-	SINE	Alu	Name=AluSx3
ADediting_120966	chr1_46586859_-	SINE	Alu	Name=AluSx3
ADediting_120967	chr1_46586874_-	SINE	Alu	Name=AluSx3
ADediting_120968	chr1_46586880_-	SINE	Alu	Name=AluSx3
ADediting_120969	chr1_46586893_-	SINE	Alu	Name=AluSx3
ADediting_120970	chr1_46586904_-	SINE	Alu	Name=AluSx3
ADediting_120971	chr1_46586905_-	SINE	Alu	Name=AluSx3
ADediting_120972	chr1_46586913_-	SINE	Alu	Name=AluSx3
ADediting_120973	chr1_46586914_-	SINE	Alu	Name=AluSx3
ADediting_120974	chr1_46586916_-	SINE	Alu	Name=AluSx3
ADediting_120975	chr1_46586919_-	SINE	Alu	Name=AluSx3
ADediting_120976	chr1_46586923_-	SINE	Alu	Name=AluSx3
ADediting_120977	chr1_46586929_-	SINE	Alu	Name=AluSx3
ADediting_120978	chr1_46586936_-	SINE	Alu	Name=AluSx3
ADediting_120979	chr1_46586940_-	SINE	Alu	Name=AluSx3
ADediting_120980	chr1_46586946_-	SINE	Alu	Name=AluSx3
ADediting_120981	chr1_46586956_-	SINE	Alu	Name=AluSx3
ADediting_120982	chr1_46586972_-	SINE	Alu	Name=AluSx3
ADediting_120983	chr1_46586975_-	SINE	Alu	Name=AluSx3
ADediting_120984	chr1_46586976_-	SINE	Alu	Name=AluSx3
ADediting_120985	chr1_46586977_-	SINE	Alu	Name=AluSx3
ADediting_120986	chr1_46586982_-	SINE	Alu	Name=AluSx3
ADediting_120987	chr1_46586985_-	SINE	Alu	Name=AluSx3
ADediting_120988	chr1_46586986_-	SINE	Alu	Name=AluSx3
ADediting_120989	chr1_46586989_-	SINE	Alu	Name=AluSx3
ADediting_120990	chr1_46586992_-	SINE	Alu	Name=AluSx3
ADediting_120991	chr1_46587003_-	SINE	Alu	Name=AluSx3
ADediting_120992	chr1_46587004_-	SINE	Alu	Name=AluSx3
ADediting_120993	chr1_46587011_-	SINE	Alu	Name=AluSx3
ADediting_120994	chr1_46587013_-	SINE	Alu	Name=AluSx3
ADediting_120995	chr1_46587014_-	SINE	Alu	Name=AluSx3
ADediting_120996	chr1_46587023_-	SINE	Alu	Name=AluSx3
ADediting_120997	chr1_46587026_-	SINE	Alu	Name=AluSx3
ADediting_120998	chr1_46587028_-	SINE	Alu	Name=AluSx3
ADediting_120999	chr1_46587037_-	SINE	Alu	Name=AluSx3
ADediting_121000	chr1_46587042_-	SINE	Alu	Name=AluSx3
ADediting_121001	chr1_46587047_-	SINE	Alu	Name=AluSx3
ADediting_121002	chr1_46587056_-	SINE	Alu	Name=AluSx3
ADediting_121003	chr1_46587060_-	SINE	Alu	Name=AluSx3
ADediting_121004	chr1_46587061_-	SINE	Alu	Name=AluSx3
ADediting_121005	chr1_46587074_-	SINE	Alu	Name=AluSx3
ADediting_121006	chr1_46587077_-	SINE	Alu	Name=AluSx3
ADediting_121007	chr1_46587082_-	SINE	Alu	Name=AluSx3
ADediting_121008	chr1_46587083_-	SINE	Alu	Name=AluSx3
ADediting_121009	chr1_46587091_-	SINE	Alu	Name=AluSx3
ADediting_121010	chr1_46587099_-	SINE	Alu	Name=AluSx3
ADediting_121012	chr1_46587545_-	SINE	Alu	Name=AluSp
ADediting_121013	chr1_46587552_-	SINE	Alu	Name=AluSp
ADediting_121014	chr1_46587561_-	SINE	Alu	Name=AluSp
ADediting_121015	chr1_46587573_-	SINE	Alu	Name=AluSp
ADediting_121016	chr1_46587574_-	SINE	Alu	Name=AluSp
ADediting_121017	chr1_46587575_-	SINE	Alu	Name=AluSp
ADediting_121018	chr1_46587601_-	SINE	Alu	Name=AluSp
ADediting_121019	chr1_46587606_-	SINE	Alu	Name=AluSp
ADediting_121020	chr1_46587614_-	SINE	Alu	Name=AluSp
ADediting_121021	chr1_46587645_-	SINE	Alu	Name=AluSp
ADediting_121022	chr1_46587652_-	SINE	Alu	Name=AluSp
ADediting_121023	chr1_46587655_-	SINE	Alu	Name=AluSp
ADediting_121024	chr1_46587689_-	SINE	Alu	Name=AluSp
ADediting_121025	chr1_46587693_-	SINE	Alu	Name=AluSp
ADediting_121026	chr1_46587695_-	SINE	Alu	Name=AluSp
ADediting_121027	chr1_46587705_-	SINE	Alu	Name=AluSp
ADediting_121028	chr1_46587717_-	SINE	Alu	Name=AluSp
ADediting_121029	chr1_46587730_-	SINE	Alu	Name=AluSp
ADediting_121030	chr1_46587731_-	SINE	Alu	Name=AluSp
ADediting_121031	chr1_46587734_-	SINE	Alu	Name=AluSp
ADediting_121032	chr1_46587735_-	SINE	Alu	Name=AluSp
ADediting_121033	chr1_46587754_-	SINE	Alu	Name=AluSp
ADediting_121034	chr1_46587765_-	SINE	Alu	Name=AluSp
ADediting_121035	chr1_46587778_-	SINE	Alu	Name=AluSp
ADediting_121036	chr1_46587804_-	SINE	Alu	Name=AluSp
ADediting_121037	chr1_46587816_-	SINE	Alu	Name=AluSp
ADediting_121038	chr1_46588563_-	SINE	Alu	Name=AluYe5
ADediting_121039	chr1_46588564_-	SINE	Alu	Name=AluYe5
ADediting_121040	chr1_46588640_-	SINE	Alu	Name=AluYe5
ADediting_121041	chr1_46588695_-	SINE	Alu	Name=AluYe5
ADediting_121042	chr1_46588697_-	SINE	Alu	Name=AluYe5
ADediting_121046	chr1_46591983_-	SINE	Alu	Name=AluSx1
ADediting_121047	chr1_46592005_-	SINE	Alu	Name=AluSx1
ADediting_121048	chr1_46592068_-	SINE	Alu	Name=AluSx1
ADediting_121049	chr1_46592091_-	SINE	Alu	Name=AluSx1
ADediting_121050	chr1_46592096_-	SINE	Alu	Name=AluSx1
ADediting_121051	chr1_46592127_-	SINE	Alu	Name=AluSx1
ADediting_121052	chr1_46592128_-	SINE	Alu	Name=AluSx1
ADediting_121053	chr1_46592157_-	SINE	Alu	Name=AluSx1
ADediting_121054	chr1_46592158_-	SINE	Alu	Name=AluSx1
ADediting_121055	chr1_46592177_-	SINE	Alu	Name=AluSx1
ADediting_121056	chr1_46592183_-	SINE	Alu	Name=AluSx1
ADediting_121057	chr1_46592226_-	SINE	Alu	Name=AluSx1
ADediting_121058	chr1_46592234_-	SINE	Alu	Name=AluSx1
ADediting_121059	chr1_46592238_-	SINE	Alu	Name=AluSx1
ADediting_121060	chr1_46593251_-	SINE	Alu	Name=AluJb
ADediting_121061	chr1_46593264_-	SINE	Alu	Name=AluJb
ADediting_121062	chr1_46593266_-	SINE	Alu	Name=AluJb
ADediting_121063	chr1_46593271_-	SINE	Alu	Name=AluJb
ADediting_121064	chr1_46593275_-	SINE	Alu	Name=AluJb
ADediting_121065	chr1_46593288_-	SINE	Alu	Name=AluJb
ADediting_121066	chr1_46593295_-	SINE	Alu	Name=AluJb
ADediting_121067	chr1_46593296_-	SINE	Alu	Name=AluJb
ADediting_121068	chr1_46593309_-	SINE	Alu	Name=AluJb
ADediting_121069	chr1_46593310_-	SINE	Alu	Name=AluJb
ADediting_121070	chr1_46593314_-	SINE	Alu	Name=AluJb
ADediting_121071	chr1_46593327_-	SINE	Alu	Name=AluJb
ADediting_121072	chr1_46593331_-	SINE	Alu	Name=AluJb
ADediting_121073	chr1_46593337_-	SINE	Alu	Name=AluJb
ADediting_121074	chr1_46593347_-	SINE	Alu	Name=AluJb
ADediting_121075	chr1_46593355_-	SINE	Alu	Name=AluJb
ADediting_121076	chr1_46593358_-	SINE	Alu	Name=AluJb
ADediting_121077	chr1_46593359_-	SINE	Alu	Name=AluJb
ADediting_121078	chr1_46593367_-	SINE	Alu	Name=AluJb
ADediting_121079	chr1_46593368_-	SINE	Alu	Name=AluJb
ADediting_121080	chr1_46593381_-	SINE	Alu	Name=AluJb
ADediting_121081	chr1_46593392_-	SINE	Alu	Name=AluJb
ADediting_121082	chr1_46593393_-	SINE	Alu	Name=AluJb
ADediting_121083	chr1_46593396_-	SINE	Alu	Name=AluJb
ADediting_121084	chr1_46593596_-	SINE	Alu	Name=AluSz
ADediting_121085	chr1_46593602_-	SINE	Alu	Name=AluSz
ADediting_121086	chr1_46593614_-	SINE	Alu	Name=AluSz
ADediting_121087	chr1_46593641_-	SINE	Alu	Name=AluSz
ADediting_121088	chr1_46593642_-	SINE	Alu	Name=AluSz
ADediting_121089	chr1_46593654_-	SINE	Alu	Name=AluSz
ADediting_121090	chr1_46593655_-	SINE	Alu	Name=AluSz
ADediting_121091	chr1_46593667_-	SINE	Alu	Name=AluSz
ADediting_121092	chr1_46593671_-	SINE	Alu	Name=AluSz
ADediting_121093	chr1_46593692_-	SINE	Alu	Name=AluSz
ADediting_121094	chr1_46593695_-	SINE	Alu	Name=AluSz
ADediting_121095	chr1_46593707_-	SINE	Alu	Name=AluSz
ADediting_121096	chr1_46593712_-	SINE	Alu	Name=AluSz
ADediting_121097	chr1_46593716_-	SINE	Alu	Name=AluSz
ADediting_121098	chr1_46593724_-	SINE	Alu	Name=AluSz
ADediting_121099	chr1_46593732_-	SINE	Alu	Name=AluSz
ADediting_121100	chr1_46593734_-	SINE	Alu	Name=AluSz
ADediting_121101	chr1_46593737_-	SINE	Alu	Name=AluSz
ADediting_121102	chr1_46593744_-	SINE	Alu	Name=AluSz
ADediting_121103	chr1_46593756_-	SINE	Alu	Name=AluSz
ADediting_121104	chr1_46593769_-	SINE	Alu	Name=AluSz
ADediting_121105	chr1_46593773_-	SINE	Alu	Name=AluSz
ADediting_121106	chr1_46593774_-	SINE	Alu	Name=AluSz
ADediting_121107	chr1_46593780_-	SINE	Alu	Name=AluSz
ADediting_121108	chr1_46593793_-	SINE	Alu	Name=AluSz
ADediting_121109	chr1_46593794_-	SINE	Alu	Name=AluSz
ADediting_121110	chr1_46593799_-	SINE	Alu	Name=AluSz
ADediting_121111	chr1_46593809_-	SINE	Alu	Name=AluSz
ADediting_121112	chr1_46593830_-	SINE	Alu	Name=AluSz
ADediting_121113	chr1_46593850_-	SINE	Alu	Name=AluSz
ADediting_121114	chr1_46594732_-	SINE	Alu	Name=AluJb
ADediting_121115	chr1_46594736_-	SINE	Alu	Name=AluJb
ADediting_121116	chr1_46594738_-	SINE	Alu	Name=AluJb
ADediting_121117	chr1_46594743_-	SINE	Alu	Name=AluJb
ADediting_121118	chr1_46594750_-	SINE	Alu	Name=AluJb
ADediting_121119	chr1_46594760_-	SINE	Alu	Name=AluJb
ADediting_121120	chr1_46594803_-	SINE	Alu	Name=AluJb
ADediting_121121	chr1_46594828_-	SINE	Alu	Name=AluJb
ADediting_121122	chr1_46594839_-	SINE	Alu	Name=AluJb
ADediting_121123	chr1_46594900_-	SINE	Alu	Name=AluJb
ADediting_121124	chr1_46594901_-	SINE	Alu	Name=AluJb
ADediting_121125	chr1_46594904_-	SINE	Alu	Name=AluJb
ADediting_121126	chr1_46594905_-	SINE	Alu	Name=AluJb
ADediting_121127	chr1_46594925_-	SINE	Alu	Name=AluJb
ADediting_121128	chr1_46595814_-	SINE	Alu	Name=AluJb
ADediting_121129	chr1_46595819_-	SINE	Alu	Name=AluJb
ADediting_121130	chr1_46595820_-	SINE	Alu	Name=AluJb
ADediting_121131	chr1_46595854_-	SINE	Alu	Name=AluJb
ADediting_121132	chr1_46595975_-	SINE	Alu	Name=AluJb
ADediting_121133	chr1_46596020_-	SINE	Alu	Name=AluJb
ADediting_121134	chr1_46596021_-	SINE	Alu	Name=AluJb
ADediting_121135	chr1_46596023_-	SINE	Alu	Name=AluJb
ADediting_121136	chr1_46601189_-	SINE	Alu	Name=AluSx1
ADediting_121137	chr1_46601190_-	SINE	Alu	Name=AluSx1
ADediting_121138	chr1_46601198_-	SINE	Alu	Name=AluSx1
ADediting_121139	chr1_46602209_-	SINE	Alu	Name=AluSx
ADediting_121140	chr1_46602365_-	SINE	Alu	Name=AluSx
ADediting_121141	chr1_46602368_-	SINE	Alu	Name=AluSx
ADediting_121142	chr1_46602374_-	SINE	Alu	Name=AluSx
ADediting_121143	chr1_46605694_-	SINE	Alu	Name=AluJb
ADediting_121144	chr1_46605697_-	SINE	Alu	Name=AluJb
ADediting_121145	chr1_46605708_-	SINE	Alu	Name=AluJb
ADediting_121146	chr1_46605720_-	SINE	Alu	Name=AluJb
ADediting_121147	chr1_46605730_-	SINE	Alu	Name=AluJb
ADediting_121148	chr1_46605734_-	SINE	Alu	Name=AluJb
ADediting_121149	chr1_46605743_-	SINE	Alu	Name=AluJb
ADediting_121150	chr1_46605744_-	SINE	Alu	Name=AluJb
ADediting_121151	chr1_46605757_-	SINE	Alu	Name=AluJb
ADediting_121152	chr1_46605770_-	SINE	Alu	Name=AluJb
ADediting_121153	chr1_46605801_-	SINE	Alu	Name=AluJb
ADediting_121154	chr1_46605893_-	SINE	Alu	Name=AluJb
ADediting_121155	chr1_46607115_-	SINE	Alu	Name=AluY
ADediting_121156	chr1_46607182_-	SINE	Alu	Name=AluY
ADediting_121157	chr1_46607260_-	SINE	Alu	Name=AluY
ADediting_1520356	chr1_46571434_-	SINE	Alu	Name=AluJo
ADediting_1520357	chr1_46571447_-	SINE	Alu	Name=AluJo
ADediting_1520358	chr1_46571537_-	SINE	Alu	Name=AluJo
ADediting_1520359	chr1_46571541_-	SINE	Alu	Name=AluJo
ADediting_1520360	chr1_46588643_-	SINE	Alu	Name=AluYe5
ADediting_1520361	chr1_46588683_-	SINE	Alu	Name=AluYe5
ADediting_1520362	chr1_46592236_-	SINE	Alu	Name=AluSx1
ADediting_1520363	chr1_46593747_-	SINE	Alu	Name=AluSz
ADediting_1520364	chr1_46594918_-	SINE	Alu	Name=AluJb
ADediting_1520365	chr1_46594961_-	SINE	Alu	Name=AluJb
ADediting_1520366	chr1_46595828_-	SINE	Alu	Name=AluJb
ADediting_1520367	chr1_46595849_-	SINE	Alu	Name=AluJb
ADediting_1520368	chr1_46595873_-	SINE	Alu	Name=AluJb
ADediting_1520369	chr1_46595880_-	SINE	Alu	Name=AluJb
ADediting_1520370	chr1_46595921_-	SINE	Alu	Name=AluJb
ADediting_1520371	chr1_46595923_-	SINE	Alu	Name=AluJb
ADediting_1520372	chr1_46595924_-	SINE	Alu	Name=AluJb
ADediting_1520373	chr1_46598650_-	SINE	MIR	Name=MIR
ADediting_1520374	chr1_46598656_-	SINE	MIR	Name=MIR
ADediting_1520376	chr1_46598997_-	SINE	MIR	Name=MIRb
ADediting_1520377	chr1_46599058_-	SINE	MIR	Name=MIRb
ADediting_1520378	chr1_46601013_-	SINE	Alu	Name=AluSx1
ADediting_1520379	chr1_46602207_-	SINE	Alu	Name=AluSx
ADediting_1520380	chr1_46605727_-	SINE	Alu	Name=AluJb
ADediting_1520381	chr1_46605738_-	SINE	Alu	Name=AluJb
ADediting_1520382	chr1_46605752_-	SINE	Alu	Name=AluJb
ADediting_1520383	chr1_46605762_-	SINE	Alu	Name=AluJb
ADediting_1520384	chr1_46605766_-	SINE	Alu	Name=AluJb
ADediting_1520385	chr1_46605821_-	SINE	Alu	Name=AluJb
ADediting_1520386	chr1_46607190_-	SINE	Alu	Name=AluY
ADediting_1520387	chr1_46607248_-	SINE	Alu	Name=AluY
ADediting_1520388	chr1_46607250_-	SINE	Alu	Name=AluY
ADediting_1520389	chr1_46607309_-	SINE	Alu	Name=AluY
ADediting_1520390	chr1_46610423_-	SINE	Alu	Name=AluSp
ADediting_1520391	chr1_46610495_-	SINE	Alu	Name=AluSp
ADediting_1601086	chr1_46593810_-	SINE	Alu	Name=AluSz

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RNA A-to-I editing events in the alternative splicing sites for MKNK1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	ADeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
A3SS	ADediting_121113	chr1_46593850_-	46593846:46593868	3ss	2i	TTTTTTTTTTTTTCAGATAGAGT	3.16	TTTTTTTTTTTTTCAGATGGAGT	-4.79
ES	ADediting_121113	chr1_46593850_-	46593850:46593872	3ss	3e	TTTTTTTTTTTTTTTTTCAGATA	12.91	TTTTTTTTTTTTTTTTTCAGATG	13.03
ES	ADediting_1520358	chr1_46571537_-	46571537:46571559	3ss	3e	TCCTTTTTTTTCCTTTTTAGACA	11.82	TCCTTTTTTTTCCTTTTTAGACG	11.58
ES	ADediting_1520359	chr1_46571541_-	46571537:46571559	3ss	2i	TCCTTTTTTTTCCTTTTTAGACA	11.82	TCCTTTTTTTTCCTTTTTGGACA	3.86
ES	ADediting_121105	chr1_46593773_-	46593773:46593781	5ss	6i	CAGGTTCAA	1.19	CAGGTTCAG	2.78
ES	ADediting_121106	chr1_46593774_-	46593773:46593781	5ss	5i	CAGGTTCAA	1.19	CAGGTTCGA	5.36
ES	ADediting_121107	chr1_46593780_-	46593773:46593781	5ss	2e	CAGGTTCAA	1.19	CGGGTTCAA	-6.26
ME1	ADediting_121113	chr1_46593850_-	46593850:46593872	3ss	3e	TTTTTTTTTTTTTTTTTCAGATA	12.91	TTTTTTTTTTTTTTTTTCAGATG	13.03
ME1	ADediting_121105	chr1_46593773_-	46593773:46593781	5ss	6i	CAGGTTCAA	1.19	CAGGTTCAG	2.78
ME1	ADediting_121106	chr1_46593774_-	46593773:46593781	5ss	5i	CAGGTTCAA	1.19	CAGGTTCGA	5.36
ME1	ADediting_121107	chr1_46593780_-	46593773:46593781	5ss	2e	CAGGTTCAA	1.19	CGGGTTCAA	-6.26

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MKNK1

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for MKNK1

- Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MKNK1

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_107020	chr1_37500952_-	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-5581-3p	chr1	46557994	46558001	8mer-1a	46557994	46558018	145	-18.69
ADediting_107020	chr1_37500952_-	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-5581-3p	chr1	46557994	46558001	8mer-1a	46557994	46558018	145	-18.69
ADediting_107020	chr1_37500952_-	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-5581-3p	chr1	46557994	46558001	8mer-1a	46557994	46558018	145	-18.69
ADediting_107020	chr1_37500952_-	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-5581-3p	chr1	46557994	46558001	8mer-1a	46557994	46558018	145	-18.69
ADediting_107020	chr1_37500952_-	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-5581-3p	chr1	46557994	46558001	8mer-1a	46557994	46558018	145	-18.69
ADediting_107020	chr1_37500952_-	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-5581-3p	chr1	46557994	46558001	8mer-1a	46557994	46558018	145	-18.69
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-589-3p	chr1	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-589-3p	chr1	46558473	46558479	7mer-m8	46558472	46558495	160	-18
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-589-3p	chr1	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-589-3p	chr1	46558473	46558479	7mer-m8	46558472	46558495	160	-18
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-589-3p	chr1	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-589-3p	chr1	46558473	46558479	7mer-m8	46558472	46558495	160	-18
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000524749.5	MKNK1-217	hsa-miR-589-3p	chr1	46558473	46558479	7mer-m8	46558472	46558495	160	-18
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-589-3p	chr1	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-589-3p	chr1	46558473	46558479	7mer-m8	46558472	46558495	160	-18
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-589-3p	chr1	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-589-3p	chr1	46558473	46558479	7mer-m8	46558472	46558495	160	-18
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-589-3p	chr1	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
ADediting_1337757	chr7_5495852_-	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-589-3p	chr1	46558473	46558479	7mer-m8	46558472	46558495	160	-18
ADediting_1337758	chr7_5495892_-	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-589-5p	chr1	46558427	46558434	8mer-1a	46558427	46558448	144	-20.93
ADediting_1337758	chr7_5495892_-	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-589-5p	chr1	46558427	46558434	8mer-1a	46558427	46558448	144	-20.93
ADediting_1337758	chr7_5495892_-	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-589-5p	chr1	46558427	46558434	8mer-1a	46558427	46558448	144	-20.93
ADediting_1337758	chr7_5495892_-	ENSG00000079277.21	ENST00000524749.5	MKNK1-217	hsa-miR-589-5p	chr1	46558427	46558434	8mer-1a	46558427	46558448	144	-20.93
ADediting_1337758	chr7_5495892_-	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-589-5p	chr1	46558427	46558434	8mer-1a	46558427	46558448	144	-20.93
ADediting_1337758	chr7_5495892_-	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-589-5p	chr1	46558427	46558434	8mer-1a	46558427	46558448	144	-20.93
ADediting_1337758	chr7_5495892_-	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-589-5p	chr1	46558427	46558434	8mer-1a	46558427	46558448	144	-20.93
ADediting_1631458	chr19_40282624_-	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-641	chr1	46558106	46558112	7mer-m8	46558105	46558132	160	-23.9
ADediting_1631458	chr19_40282624_-	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-641	chr1	46558106	46558112	7mer-m8	46558105	46558132	160	-23.9
ADediting_1631458	chr19_40282624_-	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-641	chr1	46558106	46558112	7mer-m8	46558105	46558132	160	-23.9
ADediting_1631458	chr19_40282624_-	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-641	chr1	46558106	46558112	7mer-m8	46558105	46558132	160	-23.9
ADediting_1631458	chr19_40282624_-	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-641	chr1	46558106	46558112	7mer-m8	46558105	46558132	160	-23.9
ADediting_1631458	chr19_40282624_-	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-641	chr1	46558106	46558112	7mer-m8	46558105	46558132	160	-23.9
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-5585-3p	chr1	46557536	46557542	7mer-m8	46557535	46557556	167	-24.76
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-5585-3p	chr1	46558461	46558467	7mer-m8	46558460	46558484	146	-21.2
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-5585-3p	chr1	46557536	46557542	7mer-m8	46557535	46557556	167	-24.76
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-5585-3p	chr1	46558461	46558467	7mer-m8	46558460	46558484	146	-21.2
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-5585-3p	chr1	46557536	46557542	7mer-m8	46557535	46557556	167	-24.76
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-5585-3p	chr1	46558461	46558467	7mer-m8	46558460	46558484	146	-21.2
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000524749.5	MKNK1-217	hsa-miR-5585-3p	chr1	46558461	46558467	7mer-m8	46558460	46558484	146	-21.2
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-5585-3p	chr1	46557536	46557542	7mer-m8	46557535	46557556	167	-24.76
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-5585-3p	chr1	46558461	46558467	7mer-m8	46558460	46558484	146	-21.2
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-5585-3p	chr1	46557536	46557542	7mer-m8	46557535	46557556	167	-24.76
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-5585-3p	chr1	46558461	46558467	7mer-m8	46558460	46558484	146	-21.2
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-5585-3p	chr1	46557536	46557542	7mer-m8	46557535	46557556	167	-24.76
ADediting_98289	chr1_32086992_+	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-5585-3p	chr1	46558461	46558467	7mer-m8	46558460	46558484	146	-21.2

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-4512	chr1	46558437	46558443	7mer-m8	46558436	46558457	144	-19.37
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-4512	chr1	46558546	46558553	8mer-1a	46558546	46558568	142	-13.68
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-4512	chr1	46558437	46558443	7mer-m8	46558436	46558457	144	-19.37
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-4512	chr1	46558546	46558553	8mer-1a	46558546	46558568	142	-13.68
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-4512	chr1	46558437	46558443	7mer-m8	46558436	46558457	144	-19.37
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-4512	chr1	46558546	46558553	8mer-1a	46558546	46558568	142	-13.68
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000524749.5	MKNK1-217	hsa-miR-4512	chr1	46558437	46558443	7mer-m8	46558436	46558457	144	-19.37
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000524749.5	MKNK1-217	hsa-miR-4512	chr1	46558546	46558553	8mer-1a	46558546	46558568	142	-13.68
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-4512	chr1	46558437	46558443	7mer-m8	46558436	46558457	144	-19.37
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-4512	chr1	46558546	46558553	8mer-1a	46558546	46558568	142	-13.68
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-4512	chr1	46558437	46558443	7mer-m8	46558436	46558457	144	-19.37
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-4512	chr1	46558546	46558553	8mer-1a	46558546	46558568	142	-13.68
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-4512	chr1	46558437	46558443	7mer-m8	46558436	46558457	144	-19.37
ADediting_496066	chr15_66496985_-	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-4512	chr1	46558546	46558553	8mer-1a	46558546	46558568	142	-13.68
ADediting_527135	chr16_24203190_+	ENSG00000079277.21	ENST00000341183.9	MKNK1-201	hsa-miR-1273h-3p	chr1	46558002	46558008	7mer-m8	46558001	46558022	148	-19.95
ADediting_527135	chr16_24203190_+	ENSG00000079277.21	ENST00000371945.9	MKNK1-203	hsa-miR-1273h-3p	chr1	46558002	46558008	7mer-m8	46558001	46558022	148	-19.95
ADediting_527135	chr16_24203190_+	ENSG00000079277.21	ENST00000371946.9	MKNK1-204	hsa-miR-1273h-3p	chr1	46558002	46558008	7mer-m8	46558001	46558022	148	-19.95
ADediting_527135	chr16_24203190_+	ENSG00000079277.21	ENST00000649800.1	MKNK1-229	hsa-miR-1273h-3p	chr1	46558002	46558008	7mer-m8	46558001	46558022	148	-19.95
ADediting_527135	chr16_24203190_+	ENSG00000079277.21	ENST00000650026.1	MKNK1-230	hsa-miR-1273h-3p	chr1	46558002	46558008	7mer-m8	46558001	46558022	148	-19.95
ADediting_527135	chr16_24203190_+	ENSG00000079277.21	ENST00000650508.1	MKNK1-231	hsa-miR-1273h-3p	chr1	46558002	46558008	7mer-m8	46558001	46558022	148	-19.95

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MKNK1

- RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000649800.1	protein_coding
ENST00000371946.9	protein_coding
ENST00000532110.1	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1520356	ENST00000649800.1	chr1_46571434_-	843	-990.70	-991.40	-995.00
ADediting_1520357	ENST00000649800.1	chr1_46571447_-	830	-994.80	-991.40	-995.00
ADediting_1520358	ENST00000649800.1	chr1_46571537_-	740	-991.10	-991.40	-995.00
ADediting_1520356	ENST00000371946.9	chr1_46571434_-	763	-946.40	-947.10	-950.70
ADediting_1520357	ENST00000371946.9	chr1_46571447_-	750	-950.50	-947.10	-950.70
ADediting_1520358	ENST00000371946.9	chr1_46571537_-	660	-946.80	-947.10	-950.70
ADediting_121123	ENST00000532110.1	chr1_46594900_-	160	-153.90	-153.90	-162.80
ADediting_121124	ENST00000532110.1	chr1_46594901_-	159	-153.70	-153.90	-162.80
ADediting_121125	ENST00000532110.1	chr1_46594904_-	156	-156.50	-153.90	-162.80
ADediting_121126	ENST00000532110.1	chr1_46594905_-	155	-154.10	-153.90	-162.80
ADediting_1520364	ENST00000532110.1	chr1_46594918_-	142	-159.40	-153.90	-162.80
ADediting_121127	ENST00000532110.1	chr1_46594925_-	135	-158.00	-153.90	-162.80
ADediting_1520365	ENST00000532110.1	chr1_46594961_-	99	-153.20	-153.90	-162.80

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for MKNK1

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	ADediting_120958	chr1_46579048_-	0.743849936747648	0.0186323406539162	0.1047495477589	-0.0923137701643285	1.17510561839993e-13	0.40485835905245
CER	ADediting_120961	chr1_46586834_-	1.06959104046653e-08	0.445965264503191	2.40825246678463e-11	0.51083504376963	0.0112796310710572	0.206387305624081
CER	ADediting_120962	chr1_46586841_-	4.13243488895577e-08	0.429542262236491	5.44428421308924e-10	0.479347665297432	0.00171083019535105	0.253991229430872
TCX	ADediting_120962	chr1_46586841_-	0.000311544239826522	0.290445908920694	0.000166795136131239	0.302671067403041	0.581660374658785	-0.0453419410078683
CER	ADediting_120963	chr1_46586842_-	8.16957580533325e-09	0.449137782323331	2.9924232619843e-10	0.485644502980344	0.00118365527773923	0.262314819881144
CER	ADediting_120967	chr1_46586874_-	0.000459093951466248	0.282575101116447	4.94690517592841e-05	0.325021374770952	0.76921766356763	0.0241544446461585
CER	ADediting_120969	chr1_46586893_-	9.16275157409268e-08	0.41944230654965	4.07249880506126e-12	0.52743974902356	0.207050856880828	0.103607950560038
CER	ADediting_120970	chr1_46586904_-	1.93333993463313e-07	0.40966091976395	2.40900380226268e-11	0.510832049114959	0.642479909043559	0.0382103692449282
CER	ADediting_120971	chr1_46586905_-	0.00299684594264312	0.240779681209566	5.20254560915647e-05	0.324129014656881	0.952874390334508	0.00486597449979541
CER	ADediting_120972	chr1_46586913_-	2.65665815149651e-05	0.335809737092842	4.81947650926294e-08	0.427617054617883	0.891292939075476	0.011252705995543
CER	ADediting_120974	chr1_46586916_-	0.00147939093405585	0.25730761369817	9.00813718779753e-05	0.3142207054472	0.484094284597249	-0.0575671020554128
CER	ADediting_120975	chr1_46586919_-	9.64895847457596e-05	0.312955621455729	2.46516768331789e-08	0.435922680370132	0.669594131436364	0.0351233955533318
CER	ADediting_120976	chr1_46586923_-	0.00247734340713194	0.245344290877759	9.22561791991944e-06	0.353290496737573	0.689567141888952	-0.0328805878530711
CER	ADediting_120978	chr1_46586936_-	0.00361525526603466	0.23619827991561	4.5573464747344e-05	0.326468097396701	0.97943486099019	-0.00212247183108904
CER	ADediting_121003	chr1_46587060_-	0.00229263023227455	0.24717872045686	4.39268886318879e-06	0.36496345470568	0.0884011801803817	0.139607961369507
CER	ADediting_121004	chr1_46587061_-	0.0063469716098662	0.221916842979393	7.21465351283084e-06	0.357209363853614	0.0665781948611265	0.150192797472647
CER	ADediting_121005	chr1_46587074_-	0.000127898603094596	0.307707654010239	4.25451810436316e-07	0.3989786087542	0.0471347235743685	0.162362846147949
CER	ADediting_121006	chr1_46587077_-	1.7914369322722e-05	0.342445231346591	9.88883532603987e-10	0.472938273315305	0.00645478492324939	0.22147615347061
CER	ADediting_121007	chr1_46587082_-	1.7646813277619e-06	0.378710918596314	1.950487364337e-11	0.512852353474986	0.00264323062283982	0.243799524690393
CER	ADediting_121008	chr1_46587083_-	1.96791754423756e-06	0.377100450551129	3.86733693140587e-11	0.50625386822974	0.00618097576405332	0.222608570182807
CER	ADediting_121009	chr1_46587091_-	0.000550868628131589	0.278794723754211	0.000138886914213892	0.306153963937153	0.652298328881486	0.0370866039325987
CER	ADediting_121010	chr1_46587099_-	9.45452786348466e-08	0.419037856996004	1.40319225628032e-07	0.413897519681906	0.0875481925366845	0.139979752094921
CER	ADediting_121012	chr1_46587545_-	3.33682212663639e-05	0.331900804423398	0.000757760397858729	0.272048755084807	0.369073823494272	0.0738561224419805
DLPFC	ADediting_121014	chr1_46587561_-	4.12118486356773e-07	0.282824559111479	9.95032627138209e-09	0.318311356616725	0.0471019444488769	0.112857561034693
CER	ADediting_121014	chr1_46587561_-	4.18066599493012e-10	0.482142069713969	9.91799802267874e-15	0.577737458308434	0.00814439065589625	0.215308151463931
CER	ADediting_121015	chr1_46587573_-	8.91336991213712e-05	0.314414892855497	9.3537693950668e-07	0.387922313134992	0.102777835726237	0.133733787677618
CER	ADediting_121018	chr1_46587601_-	0.00164575842644907	0.254880204060688	7.93871550007753e-06	0.35569118764663	0.0567707082277711	0.155900190740572
CER	ADediting_121019	chr1_46587606_-	0.00371381838431433	0.235534403888573	6.45263521308901e-05	0.320283481429691	0.389862486103456	0.0707114248121083
CER	ADediting_121028	chr1_46587717_-	0.0115358905688393	0.20575912356123	1.01050896564118e-05	0.351825894091143	0.233987852737701	0.0977601082593065
CER	ADediting_121029	chr1_46587730_-	0.0197221665729476	0.190223318217073	0.000151924683980654	0.304452731742418	0.861663889153728	0.0143472725762702
CER	ADediting_121030	chr1_46587731_-	0.00642913810138358	0.221580387894152	2.1874381548626e-05	0.339101145678154	0.0740252223247	0.146301630258686
CER	ADediting_121031	chr1_46587734_-	0.00552453308483434	0.225517248034307	3.47861111453386e-06	0.368540937112542	0.0699496571966308	0.148389542415996
CER	ADediting_121032	chr1_46587735_-	0.0396107440861919	0.168225404466184	0.000176337428142201	0.30160416767744	0.45709888009198	0.0611721733329295
CER	ADediting_121033	chr1_46587754_-	2.84039423557635e-05	0.33466843433778	2.71010247053375e-09	0.461802015910077	0.246093448127549	0.095286107046032
CER	ADediting_121035	chr1_46587778_-	1.29793270067433e-05	0.347761618289274	8.61698038632157e-07	0.389092694695009	0.135977915297188	0.122300169807339
CER	ADediting_121036	chr1_46587804_-	2.01484694182134e-09	0.465118173008241	2.68266841379899e-09	0.461916420845345	0.00591218292255167	0.223764596982178
CER	ADediting_121046	chr1_46591983_-	7.26861688085776e-05	0.318134496002288	1.65262590998883e-05	0.343784923220348	0.0527769783191506	0.158459258055868
CER	ADediting_121047	chr1_46592005_-	1.6479002695792e-06	0.379718096247953	8.23620504008895e-09	0.449042615747767	9.47954425682e-05	0.3132822533578
TCX	ADediting_121047	chr1_46592005_-	0.00310909634049032	0.239888316501502	0.000125163765086304	0.308113676550366	0.376847556187124	0.0726678549887651
CER	ADediting_121048	chr1_46592068_-	8.02948682954568e-12	0.521202772201921	2.97652032671176e-10	0.485699996569072	0.0564844104459162	0.156078614429323
CER	ADediting_121051	chr1_46592127_-	9.69324780755119e-12	0.51944996274023	2.82415511994007e-10	0.486246694445555	0.00208146032177492	0.249447842648973
CER	ADediting_121052	chr1_46592128_-	1.15066737514433e-08	0.445099348924229	1.23371109787949e-08	0.444271245537511	0.416699349931303	0.0667973393312581
CER	ADediting_121053	chr1_46592157_-	3.29051539031029e-05	0.332141972500018	8.54438087843274e-06	0.354518750561585	0.309036092637199	0.083611755998582
CER	ADediting_121055	chr1_46592177_-	5.38525665301295e-11	0.503010653229018	3.57821319206496e-12	0.528614231710507	0.000748013616918988	0.272325999617335
TCX	ADediting_121055	chr1_46592177_-	0.000563928023264996	0.278304804037425	0.000123556970478873	0.308356103433814	0.802488337286251	0.0205929722337447
CER	ADediting_121057	chr1_46592226_-	1.66350881873585e-10	0.491700340941456	9.5276890158796e-11	0.497340886027182	0.00047152275525139	0.282024296959475
CER	ADediting_121058	chr1_46592234_-	4.98768882081752e-12	0.52559060171287	4.36184540595873e-12	0.526814890065976	6.64736516103579e-05	0.319748430021285
CER	ADediting_121059	chr1_46592238_-	3.60819003692773e-12	0.528538642318304	1.13390437861732e-11	0.517982550670436	0.00171839933353173	0.253889831151334
CER	ADediting_121060	chr1_46593251_-	3.82358817460234e-07	0.400446977209956	5.37795816687066e-07	0.395731693636234	0.015233818195786	0.197837578339127
CER	ADediting_121064	chr1_46593275_-	5.00440429655323e-08	0.42714389113933	7.79630077518106e-08	0.421517614394382	0.0402027284980495	0.167731769636722
CER	ADediting_121066	chr1_46593295_-	1.51016686188478e-05	0.34527506661074	5.62653621589823e-06	0.361120036089223	0.0168650865335718	0.194868825011594
CER	ADediting_121068	chr1_46593309_-	3.14903386324909e-10	0.485112741352192	1.16382968761425e-09	0.471165744605851	1.81768825248923e-05	0.342202933144386
CER	ADediting_121069	chr1_46593310_-	5.55509120202495e-09	0.453623471566472	3.14068980530092e-10	0.485140421734778	0.00440495280046833	0.23127982846121
DLPFC	ADediting_121071	chr1_46593327_-	2.10615192293056e-08	0.311535926767475	5.20853580189792e-07	0.280423361227539	0.00134224336877592	0.181353546083292
CER	ADediting_121071	chr1_46593327_-	9.52897471180251e-08	0.418936577025306	3.18371703989729e-07	0.402948803329085	0.0045716311518412	0.230344087459137
CER	ADediting_121072	chr1_46593331_-	1.54084284651053e-05	0.344943305729015	0.000384040336256261	0.286227301381723	0.0560147483184212	0.156372933091998
CER	ADediting_121073	chr1_46593337_-	4.06559381157971e-12	0.527455181308124	5.40267642752559e-09	0.453944529370894	0.00332820506754198	0.238229032987857
CER	ADediting_121074	chr1_46593347_-	8.6531030267016e-13	0.541210248320073	2.03520264027081e-09	0.465006302429984	0.00169700738747589	0.254177462107885
CER	ADediting_121076	chr1_46593358_-	9.88311324911982e-08	0.418464944053063	0.000102882928806203	0.311769427663341	0.0216899922576771	0.187351776041821
CER	ADediting_121084	chr1_46593596_-	4.57282640221709e-07	0.397982551545988	6.43393635050312e-06	0.359017232006699	0.0304242623874873	0.176816745630096
TCX	ADediting_121084	chr1_46593596_-	0.00121159709478499	0.261795486150761	2.54811051580032e-05	0.336519428647433	0.309952581619429	-0.0834540731884334
CER	ADediting_121085	chr1_46593602_-	2.86125425652506e-08	0.434095890150784	5.6677361861366e-06	0.361006007983231	0.0262261890741941	0.18150274502585
CER	ADediting_121087	chr1_46593641_-	2.57463061530353e-07	0.405824193380064	3.91644305586763e-06	0.36672847020525	0.289424043662887	0.0870624533687304
CER	ADediting_121092	chr1_46593671_-	6.73436381253994e-16	0.59772615911472	1.32083603574548e-12	0.537511690473956	0.000359941419846425	0.287541120846374
CER	ADediting_121100	chr1_46593734_-	1.7030956627532e-05	0.343285958113406	0.00061818019163816	0.276375473523003	0.589569131311913	0.0443964361017496
CER	ADediting_121102	chr1_46593744_-	9.13649010158585e-08	0.419479312393805	2.1016112002975e-07	0.408548088284925	0.404378784187656	0.0685751156075342
CER	ADediting_121103	chr1_46593756_-	0.000817338720837496	0.270422062900378	1.43153067789409e-05	0.346155475773943	0.94458179857304	-0.00572349339126298
CER	ADediting_121105	chr1_46593773_-	0.00416611925870911	0.232677603077645	3.41622149850568e-05	0.331494517916483	0.620317232368263	0.0407735676933934
CER	ADediting_121106	chr1_46593774_-	0.0012308773508111	0.261443485716116	0.000122467307266983	0.308522187077164	0.152800039436256	0.117313290264599
CER	ADediting_121107	chr1_46593780_-	9.19689732113758e-06	0.353340520480258	1.79494193452612e-08	0.439777197442843	0.565622894094614	0.0472777839232194
CER	ADediting_121108	chr1_46593793_-	1.2388288564179e-06	0.383879616038236	9.22254332712548e-09	0.447714350339768	0.554190787456787	0.0486736620052506
CER	ADediting_121109	chr1_46593794_-	0.000202228460793974	0.298959245965844	8.1310519711246e-06	0.355309953366677	0.0543793581927812	0.157413909201915
CER	ADediting_121111	chr1_46593809_-	2.5173215181642e-07	0.406127438595365	6.01673633441955e-08	0.424818322914153	0.0076921597129437	0.216838584524811
CER	ADediting_121112	chr1_46593830_-	2.4033310466347e-05	0.337511659823954	1.08217359025887e-06	0.385831568059915	0.00929671721084191	0.211724312556121
CER	ADediting_121113	chr1_46593850_-	3.30363090127518e-05	0.332073343909984	0.00183167650439468	0.252418988539624	0.725441883175138	0.0289108277943315
TCX	ADediting_121113	chr1_46593850_-	2.36097681463019e-05	0.337812582659037	0.000325992029958048	0.289537338626009	0.325828423786705	0.0807694730395185
CER	ADediting_121114	chr1_46594732_-	3.0464658614025e-05	0.333468264118569	1.35849785063988e-10	0.493762250939666	0.00243472929228412	0.245756224823149
CER	ADediting_121115	chr1_46594736_-	0.000482981150234204	0.281528248472951	1.50973972567337e-09	0.468313013910831	0.00281814468486571	0.242262948668867
CER	ADediting_121116	chr1_46594738_-	5.07784087184871e-05	0.324559052970246	2.34620918538855e-10	0.488168061619897	0.00610250040546338	0.222941368961668
CER	ADediting_121117	chr1_46594743_-	4.90601150138837e-05	0.325168120930364	3.43305235544041e-09	0.459131213926103	1.95274628595835e-05	0.341006250846368
CER	ADediting_121118	chr1_46594750_-	0.00563699683076107	0.224997750589807	6.71747040884388e-06	0.358337776744467	0.900703579012662	-0.0102733126451462
CER	ADediting_121119	chr1_46594760_-	3.11185974211173e-05	0.333103344528765	1.63854561137916e-11	0.514509976986834	0.000585304070167516	0.277525013736854
CER	ADediting_121123	chr1_46594900_-	0.00336271213552254	0.237976745493479	6.70169269690257e-08	0.423449160263119	4.12129473524113e-05	0.328232134145629
CER	ADediting_121124	chr1_46594901_-	0.00371277710618286	0.235541334166871	4.93612264142977e-08	0.42731661542837	0.000490707748984335	0.281199850941638
CER	ADediting_121125	chr1_46594904_-	0.0222352721213084	0.186595915099262	2.61594128521214e-07	0.40560957865031	1.64061554206495e-05	0.343905778725413
CER	ADediting_121126	chr1_46594905_-	0.00208097089044375	0.249453340249049	2.00126069373469e-10	0.489806571362912	0.000202536047624949	0.298929761603399
CER	ADediting_121127	chr1_46594925_-	6.54251888801619e-07	0.392988847938819	3.53415574741539e-13	0.548894925759206	3.57104328788097e-05	0.330727201649043
CER	ADediting_121128	chr1_46595814_-	7.77079036552059e-06	0.356031250622852	8.39431228185918e-10	0.474711073075001	0.00441214110363612	0.231238822846656
CER	ADediting_121129	chr1_46595819_-	2.88622133407533e-05	0.334394611594463	1.21145148587725e-09	0.47072780848149	0.000661356991759011	0.274948433115697
CER	ADediting_121130	chr1_46595820_-	0.000533898926933672	0.279447589689188	4.62506345750852e-08	0.428133651064965	0.00952505894389145	0.211061177129245
CER	ADediting_121131	chr1_46595854_-	6.70910106490059e-05	0.319581863720303	2.89842062313245e-12	0.530517084514306	0.00185263338543978	0.252155983996073
CER	ADediting_121132	chr1_46595975_-	2.27227997798447e-07	0.407503273308057	6.38583163568569e-12	0.523321277489456	0.000163695581679825	0.303029873195357
CER	ADediting_121133	chr1_46596020_-	2.62571663463579e-07	0.405559268548024	3.70706372010136e-13	0.548489902352863	0.000215135377678814	0.297756442997831
CER	ADediting_121134	chr1_46596021_-	5.51378912257807e-07	0.395384026809866	5.56262378628461e-15	0.582152093946146	0.000143111759740305	0.305586948569597
CER	ADediting_121135	chr1_46596023_-	3.73366736670787e-07	0.400773239603682	9.55022216038815e-14	0.559783095141528	9.80227924721181e-05	0.312664605418271
CER	ADediting_121136	chr1_46601189_-	0.000406640046659188	0.285062762646975	2.0838179741105e-08	0.437970279463715	7.77526605794437e-05	0.31691121632054
CER	ADediting_121137	chr1_46601190_-	0.000529136431195068	0.279634253792402	3.81512314821212e-07	0.400477376893307	0.0193239452044094	0.190834355519451
CER	ADediting_121139	chr1_46602209_-	0.000116931869632456	0.309387786538344	1.44269378597234e-10	0.493151547204292	0.0298319944695798	0.177443089782158
CER	ADediting_121143	chr1_46605694_-	1.79491113550079e-05	0.342412973155176	1.04894718927731e-10	0.496374862962485	0.000815334124923397	0.270474997492535
CER	ADediting_121144	chr1_46605697_-	7.11127694203869e-05	0.318530660398557	2.91238350978835e-09	0.460991384347518	0.0035850311049804	0.236405121021965
CER	ADediting_121145	chr1_46605708_-	0.00999385778723078	0.209742567911515	0.000104850182237334	0.311418273742038	0.00230685754777463	0.247032750065991
CER	ADediting_121146	chr1_46605720_-	0.00184142971581282	0.252296249158328	4.5897488776349e-07	0.397931469298089	7.28273768167433e-05	0.318099335030299
CER	ADediting_121147	chr1_46605730_-	0.0105228257191202	0.208318660399553	2.27243057269253e-05	0.338458477021251	0.000328519732779867	0.289382226467593
CER	ADediting_121149	chr1_46605743_-	0.0127027493885976	0.203045065859258	0.000113400705952576	0.309960178619341	0.00321292838102446	0.239089291977568
CER	ADediting_121150	chr1_46605744_-	0.00633763813658168	0.221955306674401	2.06755892161255e-06	0.376367869727813	0.00160049636135146	0.25551762777571
CER	ADediting_121151	chr1_46605757_-	0.0032944851507201	0.238477853747283	9.08495399726688e-07	0.388338799479783	0.000231593504559274	0.296316447359025
CER	ADediting_121152	chr1_46605770_-	0.000152648066215535	0.304362376292324	6.95972891403557e-09	0.451009660643146	0.000167229678613602	0.302621261626119
CER	ADediting_121153	chr1_46605801_-	0.0149908289641682	0.198303261506134	1.88393671642339e-05	0.341605832375603	0.0012254144460685	0.261542707515385
CER	ADediting_121154	chr1_46605893_-	1.38223720388731e-11	0.516119412753897	1.63514825795263e-15	0.591284379671445	6.9356722730841e-07	0.392167470526227
CER	ADediting_121155	chr1_46607115_-	3.64532857518566e-05	0.330370072812769	4.41874585443007e-12	0.52669675724927	2.18764131118023e-05	0.339099581658419
CER	ADediting_121157	chr1_46607260_-	0.010060574803104	0.209559365353833	5.35653076284549e-07	0.395787302114141	0.37104408533598	0.0735535131467712
CER	ADediting_1520364	chr1_46594918_-	2.16198017932533e-05	0.339298227788826	7.34686564303284e-14	0.561918832646168	8.00690887591519e-06	0.355555029841195
CER	ADediting_1520365	chr1_46594961_-	4.76689634042567e-05	0.325676074154059	2.19752313874551e-10	0.488843685706626	8.94942503164193e-05	0.314340785905874
CER	ADediting_1520366	chr1_46595828_-	2.73708573219554e-07	0.404998401982237	7.04886421426723e-13	0.542987317149486	0.000550443756350782	0.278810841884715
CER	ADediting_1520367	chr1_46595849_-	8.53421912565906e-05	0.315211632154759	1.3052078456376e-10	0.494167998554102	3.18338102172913e-05	0.332712399221274
CER	ADediting_1520369	chr1_46595880_-	3.09995481625646e-07	0.403311323674398	9.93121298566541e-14	0.559463257262494	0.000451242636579908	0.282930187548673
CER	ADediting_1520370	chr1_46595921_-	8.76979620476461e-05	0.314712798843826	9.70958269850896e-10	0.473136698007333	0.000585942818532631	0.277502118686936
CER	ADediting_1520371	chr1_46595923_-	7.02621976106692e-05	0.318748255503233	3.96708035551902e-07	0.399941217481932	0.0762323374389025	0.14520951333856
CER	ADediting_1520372	chr1_46595924_-	7.63689191421054e-05	0.317237732241909	8.94876607808884e-08	0.419746847189178	0.030170390138203	0.177083943023053
CER	ADediting_1520373	chr1_46598650_-	4.73226983385949e-05	0.325804667631957	0.000514083504607599	0.28023461004061	0.0126713146272077	0.203115260010376
CER	ADediting_1520379	chr1_46602207_-	0.000555796447753381	0.27860861245876	4.63828322606239e-09	0.455699142723843	0.058891860528139	0.154600849781142
CER	ADediting_1520382	chr1_46605752_-	0.000608658649716274	0.276702493160336	2.87913468457886e-06	0.371410118800841	0.0740640957061995	0.146282168713263
CER	ADediting_1520384	chr1_46605766_-	0.0178282097919584	0.19323134205975	4.20979145434778e-05	0.327860389300126	0.0253997730121839	0.182499985929677
CER	ADediting_1520388	chr1_46607250_-	0.00349763539219207	0.237012178850167	7.65184491082914e-07	0.390779270195868	0.679607810881871	0.0339958155380588
CER	ADediting_1520389	chr1_46607309_-	0.00523159483629264	0.226916131291526	8.89299912322645e-07	0.388643452897894	0.0733261866332702	0.14665301458423

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	5.68135399894205e-17	0.451446838146208	2.94624611916759e-13	0.398729554538984	1.69201025231801e-30	0.590322872392762
AC	4.78121987238792e-50	0.768723072630642	4.37758906386108e-30	0.638946498815427	2.30610395819938e-18	0.515367299268341
PCC	2.61518488845946e-20	0.603169970055593	1.31515214145715e-19	0.594094034831163	1.37103595903607e-06	0.341127258466313
CER	5.86443538561492e-16	0.598717732058513	5.01161101787566e-28	0.747010136587079	5.08995448569633e-07	0.396497455712152
TCX	1.1645876611796e-21	0.679610004979517	3.15378726540827e-15	0.586420409276915	0.671597108968548	0.0348973361916922
FP	4.7024667180948e-29	0.714030286980428	4.77251513500926e-18	0.589605371404997	9.20319239416414e-08	0.387369975124002
IFG	0.00206635800814692	0.586367220575364	0.000130297942604038	0.691197775383876	0.0112381900686855	0.498309949885448
PG	5.58129032780279e-21	0.61804181964341	8.87212902393455e-24	0.650745663929597	0.964539343198233	0.0032819332915466
STG	1.348334011143e-10	0.630079152242437	3.52668329855741e-06	0.481564032125247	0.0206558650056798	0.252184566926373

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Relation with AD stages for MKNK1

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_120961	chr1_46586834_-	7.78036235338416e-05	0.370856962886186
CER	ADediting_120963	chr1_46586842_-	0.00142647738703241	0.303156718431991
CER	ADediting_121014	chr1_46587561_-	2.44721783898885e-06	0.435663394469435
CER	ADediting_121036	chr1_46587804_-	0.000308338806799927	0.340714446908788
CER	ADediting_121047	chr1_46592005_-	3.29126681603391e-07	0.467898779973781
CER	ADediting_121052	chr1_46592128_-	0.000566874672142298	0.326353990087179
CER	ADediting_121055	chr1_46592177_-	2.09324954748362e-05	0.397067100140618
CER	ADediting_121057	chr1_46592226_-	0.000363408770686195	0.336907029934025
CER	ADediting_121060	chr1_46593251_-	0.000284572436739793	0.342555408917385
CER	ADediting_121064	chr1_46593275_-	0.000235488369231268	0.346856336227336
CER	ADediting_121069	chr1_46593310_-	0.000321497102196034	0.339750810031853
CER	ADediting_121073	chr1_46593337_-	0.00118438090816569	0.307983683675343
CER	ADediting_121074	chr1_46593347_-	0.00150710238886378	0.301714108975259
CER	ADediting_121084	chr1_46593596_-	0.00091468196590361	0.314558676013871
CER	ADediting_121108	chr1_46593793_-	0.0013701181781689	0.30420982101089
CER	ADediting_121111	chr1_46593809_-	0.000554006608950701	0.326908322487695
CER	ADediting_121112	chr1_46593830_-	1.78720097966091e-05	0.400078046047401
CER	ADediting_121130	chr1_46595820_-	0.00130329349110898	0.305510760657105
CER	ADediting_121131	chr1_46595854_-	0.00136382911370895	0.304329766981264
CER	ADediting_121133	chr1_46596020_-	0.000852418163853892	0.316326956217205
CER	ADediting_121134	chr1_46596021_-	0.00110895048385554	0.309672363117452
CER	ADediting_121143	chr1_46605694_-	0.00141850785866346	0.303303312728356
CER	ADediting_121152	chr1_46605770_-	0.000451520837905032	0.331801194651629
CER	ADediting_121154	chr1_46605893_-	0.00135366124954095	0.304524757945593
CER	ADediting_121155	chr1_46607115_-	0.00108578585618766	0.310211991706447
CER	ADediting_1520364	chr1_46594918_-	2.61577601501051e-05	0.392772055065503
CER	ADediting_1520366	chr1_46595828_-	0.00129254465186168	0.30572566084993
CER	ADediting_1520367	chr1_46595849_-	0.000382034280343588	0.335739252296747
CER	ADediting_1520370	chr1_46595921_-	0.000866117967178013	0.315927986152442
CER	ADediting_1520371	chr1_46595923_-	0.000181090922883238	0.352723082698376
CER	ADediting_1520372	chr1_46595924_-	0.000437847308766438	0.332529801180083
IFG	ADediting_121058	chr1_46592234_-	0.0113059937049014	0.497952103823781
IFG	ADediting_121059	chr1_46592238_-	0.0113059937049014	0.497952103823781
IFG	ADediting_121102	chr1_46593744_-	0.0354713369979928	0.422303326441651

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	6.46172632876559e-08	0.491826433426808
TCX	8.76362434151393e-05	0.37165302503814

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RelatedDrugs for MKNK1

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
MKNK1	Q9BUB5	DB12010	Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 1	small molecule	approved|investigational

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RelatedDiseases for MKNK1

Diseases associated with this gene. (DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MKNK1	C0013146	Drug abuse	1	CTD_human
MKNK1	C0013170	Drug habituation	1	CTD_human
MKNK1	C0013222	Drug Use Disorders	1	CTD_human
MKNK1	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
MKNK1	C0038580	Substance Dependence	1	CTD_human
MKNK1	C0038586	Substance Use Disorders	1	CTD_human
MKNK1	C0236969	Substance-Related Disorders	1	CTD_human
MKNK1	C0740858	Substance abuse problem	1	CTD_human
MKNK1	C1510472	Drug Dependence	1	CTD_human
MKNK1	C4316881	Prescription Drug Abuse	1	CTD_human

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