ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for USP45

Gene summary

Gene information	Gene symbol	USP45
	Gene ID	85015
	Gene name	ubiquitin specific peptidase 45
	Synonyms	LCA19
	Cytomap	6q16.2
	Type of gene	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 45deubiquitinating enzyme 45ubiquitin specific protease 45ubiquitin thioesterase 45ubiquitin thiolesterase 45ubiquitin-specific-processing protease 45
	Modification date	20200313
	UniProtAcc	Q70EL2,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
USP45	GO:0016579	protein deubiquitination	14715245

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RNA A-to-I events for USP45

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_1282771(99433064, -), ADediting_1282772(99433075, -), ADediting_1282773(99433084, -), ADediting_1282774(99436473, -), ADediting_1282775(99436945, -), ADediting_1282776(99437018, -), ADediting_1282777(99437696, -), ADediting_1282778(99437851, -), ADediting_1282779(99437853, -), ADediting_1282780(99437904, -), ADediting_1282781(99444074, -), ADediting_1282782(99444080, -), ADediting_1282783(99444090, -), ADediting_1282784(99444150, -), ADediting_1282785(99444156, -), ADediting_1282786(99444214, -), ADediting_1282787(99444233, -), ADediting_1282788(99444281, -), ADediting_1282789(99444287, -), ADediting_1282790(99444288, -), ADediting_1282791(99444304, -), ADediting_1282792(99445228, -), ADediting_1282793(99445233, -), ADediting_1282794(99445361, -), ADediting_1282795(99445420, -), ADediting_1282796(99445421, -), ADediting_1282797(99445436, -), ADediting_1282798(99445447, -), ADediting_1282799(99446951, -), ADediting_1282800(99446952, -), ADediting_1282801(99446963, -), ADediting_1282802(99446999, -), ADediting_1282803(99458157, -), ADediting_1282804(99458209, -), ADediting_1282805(99459205, -), ADediting_1282806(99459215, -), ADediting_1282807(99459229, -), ADediting_1282808(99459232, -), ADediting_1282809(99459302, -), ADediting_1282810(99459316, -), ADediting_1282811(99459317, -), ADediting_1282812(99459340, -), ADediting_1282813(99459570, -), ADediting_1282814(99459584, -), ADediting_1282815(99459597, -), ADediting_1282816(99462780, -), ADediting_1282817(99469702, -), ADediting_1282818(99472340, -), ADediting_1282819(99472344, -), ADediting_1282820(99472353, -), ADediting_1282821(99472354, -), ADediting_1282822(99472375, -), ADediting_1282823(99472376, -), ADediting_1282824(99472391, -), ADediting_1282825(99472394, -), ADediting_1282826(99472409, -), ADediting_1282827(99472489, -), ADediting_1282828(99473283, -), ADediting_1282829(99473295, -), ADediting_1282830(99473296, -), ADediting_1282831(99473318, -), ADediting_1282832(99473319, -), ADediting_1282833(99473322, -), ADediting_1282834(99473348, -), ADediting_1282835(99473368, -), ADediting_1282836(99473374, -), ADediting_1282837(99473377, -), ADediting_1282838(99473383, -), ADediting_1282839(99473425, -), ADediting_1282840(99473435, -), ADediting_1282841(99473437, -), ADediting_1282842(99473447, -), ADediting_1282843(99473464, -), ADediting_1282844(99473465, -), ADediting_1282845(99473485, -), ADediting_1282846(99473510, -), ADediting_1282847(99473587, -), ADediting_1282848(99473590, -), ADediting_1282849(99473593, -), ADediting_1282850(99473599, -), ADediting_1282851(99473612, -), ADediting_1282852(99473633, -), ADediting_1282853(99473643, -), ADediting_1282854(99473672, -), ADediting_1282855(99473673, -), ADediting_1282856(99473679, -), ADediting_1282857(99473717, -), ADediting_1282858(99474289, -), ADediting_1282859(99474294, -), ADediting_1282860(99474295, -), ADediting_1282861(99474335, -), ADediting_1282862(99474358, -), ADediting_1282863(99474362, -), ADediting_1282864(99474397, -), ADediting_1282865(99474448, -), ADediting_1282866(99474449, -), ADediting_1282867(99474471, -), ADediting_1282868(99475384, -), ADediting_1282869(99475413, -), ADediting_1282870(99475427, -), ADediting_1282871(99475444, -), ADediting_1282872(99475453, -), ADediting_1282873(99475454, -), ADediting_1282874(99475467, -), ADediting_1282875(99475476, -), ADediting_1282876(99475480, -), ADediting_1282877(99475484, -), ADediting_1282878(99475489, -), ADediting_1282879(99475491, -), ADediting_1282880(99475493, -), ADediting_1282881(99475494, -), ADediting_1282882(99475495, -), ADediting_1282883(99475498, -), ADediting_1282884(99475509, -), ADediting_1282885(99475510, -), ADediting_1282886(99475566, -), ADediting_1282887(99475582, -), ADediting_1282888(99475589, -), ADediting_1282889(99475917, -), ADediting_1282890(99475953, -), ADediting_1282891(99475963, -), ADediting_1282892(99476016, -), ADediting_1282893(99476025, -), ADediting_1282894(99478740, -), ADediting_1282895(99484099, -), ADediting_1282896(99484279, -), ADediting_1282897(99484332, -), ADediting_1282898(99484350, -), ADediting_1282899(99484417, -), ADediting_1282900(99484605, -), ADediting_1282901(99484652, -), ADediting_1282902(99484705, -), ADediting_1282903(99489696, -), ADediting_1282904(99489702, -), ADediting_1282905(99489703, -), ADediting_1282906(99489712, -), ADediting_1282907(99489729, -), ADediting_1282908(99489755, -), ADediting_1282909(99489781, -), ADediting_1282910(99489829, -), ADediting_1282911(99489850, -), ADediting_1282912(99489851, -), ADediting_1282913(99489858, -), ADediting_1282914(99489864, -), ADediting_1282915(99489868, -), ADediting_1282916(99489869, -), ADediting_1282917(99489888, -), ADediting_1282918(99489899, -), ADediting_1282919(99489907, -), ADediting_1282920(99489937, -), ADediting_1282921(99489943, -), ADediting_1282922(99490198, -), ADediting_1282923(99490260, -), ADediting_1282924(99490261, -), ADediting_1282925(99490266, -), ADediting_1282926(99490269, -), ADediting_1282927(99490272, -), ADediting_1282928(99490285, -), ADediting_1282929(99490288, -), ADediting_1282930(99490301, -), ADediting_1282931(99490302, -), ADediting_1282932(99490312, -), ADediting_1282933(99490315, -), ADediting_1282934(99490393, -), ADediting_1282935(99490430, -), ADediting_1282936(99490447, -), ADediting_1282937(99490453, -), ADediting_1282938(99492633, -), ADediting_1282939(99494638, -), ADediting_1282940(99494650, -), ADediting_1282941(99494676, -), ADediting_1282942(99494702, -), ADediting_1282943(99494721, -), ADediting_1282944(99494728, -), ADediting_1282945(99494782, -), ADediting_1282946(99494810, -), ADediting_1282947(99494811, -), ADediting_1282948(99494812, -), ADediting_1282949(99494842, -), ADediting_1282950(99494850, -), ADediting_1282951(99503525, -), ADediting_1282952(99503558, -), ADediting_1282953(99506569, -), ADediting_1282954(99518777, -), ADediting_1584815(99433076, -), ADediting_1584816(99436493, -), ADediting_1584817(99436499, -), ADediting_1584818(99436553, -), ADediting_1584819(99437019, -), ADediting_1584820(99437057, -), ADediting_1584821(99437091, -), ADediting_1584822(99437754, -), ADediting_1584823(99437755, -), ADediting_1584824(99437769, -), ADediting_1584825(99437808, -), ADediting_1584826(99437871, -), ADediting_1584827(99437876, -), ADediting_1584828(99437885, -), ADediting_1584829(99444172, -), ADediting_1584830(99444176, -), ADediting_1584831(99445339, -), ADediting_1584832(99459419, -), ADediting_1584833(99462811, -), ADediting_1584834(99462817, -), ADediting_1584835(99462862, -), ADediting_1584836(99462901, -), ADediting_1584837(99473576, -), ADediting_1584838(99474258, -), ADediting_1584839(99474391, -), ADediting_1584840(99475483, -), ADediting_1584841(99475921, -), ADediting_1584842(99475989, -), ADediting_1584843(99481794, -), ADediting_1663179(99446947, -), ADediting_1663180(99459322, -), ADediting_1663181(99459337, -), ADediting_1663182(99459370, -), ADediting_1663183(99459371, -), ADediting_1663184(99459414, -), ADediting_1663185(99462926, -), ADediting_1663186(99490334, -), ADediting_1663187(99493590, -), ADediting_1663188(99494772, -),

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RNA editing positional annotations for USP45 using Annovar

Protein coding RNA editing(s).

ADeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
ADediting_1584833	chr6_99462811_-	stoploss	ENST00000511403.5	c.A407G	p.X136W	.	.	.

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_1282771	chr6_99433064_-	UTR3
ADediting_1282772	chr6_99433075_-	UTR3
ADediting_1282773	chr6_99433084_-	UTR3
ADediting_1282774	chr6_99436473_-	intronic
ADediting_1282775	chr6_99436945_-	intronic
ADediting_1282776	chr6_99437018_-	intronic
ADediting_1282777	chr6_99437696_-	intronic
ADediting_1282778	chr6_99437851_-	intronic
ADediting_1282779	chr6_99437853_-	intronic
ADediting_1282780	chr6_99437904_-	intronic
ADediting_1282781	chr6_99444074_-	intronic
ADediting_1282782	chr6_99444080_-	intronic
ADediting_1282783	chr6_99444090_-	intronic
ADediting_1282784	chr6_99444150_-	intronic
ADediting_1282785	chr6_99444156_-	intronic
ADediting_1282786	chr6_99444214_-	intronic
ADediting_1282787	chr6_99444233_-	intronic
ADediting_1282788	chr6_99444281_-	intronic
ADediting_1282789	chr6_99444287_-	intronic
ADediting_1282790	chr6_99444288_-	intronic
ADediting_1282791	chr6_99444304_-	intronic
ADediting_1282792	chr6_99445228_-	intronic
ADediting_1282793	chr6_99445233_-	intronic
ADediting_1282794	chr6_99445361_-	intronic
ADediting_1282795	chr6_99445420_-	intronic
ADediting_1282796	chr6_99445421_-	intronic
ADediting_1282797	chr6_99445436_-	intronic
ADediting_1282798	chr6_99445447_-	intronic
ADediting_1282799	chr6_99446951_-	intronic
ADediting_1282800	chr6_99446952_-	intronic
ADediting_1282801	chr6_99446963_-	intronic
ADediting_1282802	chr6_99446999_-	intronic
ADediting_1282803	chr6_99458157_-	intronic
ADediting_1282804	chr6_99458209_-	intronic
ADediting_1282805	chr6_99459205_-	intronic
ADediting_1282806	chr6_99459215_-	intronic
ADediting_1282807	chr6_99459229_-	intronic
ADediting_1282808	chr6_99459232_-	intronic
ADediting_1282809	chr6_99459302_-	intronic
ADediting_1282810	chr6_99459316_-	intronic
ADediting_1282811	chr6_99459317_-	intronic
ADediting_1282812	chr6_99459340_-	intronic
ADediting_1282813	chr6_99459570_-	intronic
ADediting_1282814	chr6_99459584_-	intronic
ADediting_1282815	chr6_99459597_-	intronic
ADediting_1282816	chr6_99462780_-	UTR3
ADediting_1282817	chr6_99469702_-	intronic
ADediting_1282818	chr6_99472340_-	intronic
ADediting_1282819	chr6_99472344_-	intronic
ADediting_1282820	chr6_99472353_-	intronic
ADediting_1282821	chr6_99472354_-	intronic
ADediting_1282822	chr6_99472375_-	intronic
ADediting_1282823	chr6_99472376_-	intronic
ADediting_1282824	chr6_99472391_-	intronic
ADediting_1282825	chr6_99472394_-	intronic
ADediting_1282826	chr6_99472409_-	intronic
ADediting_1282827	chr6_99472489_-	intronic
ADediting_1282828	chr6_99473283_-	intronic
ADediting_1282829	chr6_99473295_-	intronic
ADediting_1282830	chr6_99473296_-	intronic
ADediting_1282831	chr6_99473318_-	intronic
ADediting_1282832	chr6_99473319_-	intronic
ADediting_1282833	chr6_99473322_-	intronic
ADediting_1282834	chr6_99473348_-	intronic
ADediting_1282835	chr6_99473368_-	intronic
ADediting_1282836	chr6_99473374_-	intronic
ADediting_1282837	chr6_99473377_-	intronic
ADediting_1282838	chr6_99473383_-	intronic
ADediting_1282839	chr6_99473425_-	intronic
ADediting_1282840	chr6_99473435_-	intronic
ADediting_1282841	chr6_99473437_-	intronic
ADediting_1282842	chr6_99473447_-	intronic
ADediting_1282843	chr6_99473464_-	intronic
ADediting_1282844	chr6_99473465_-	intronic
ADediting_1282845	chr6_99473485_-	intronic
ADediting_1282846	chr6_99473510_-	intronic
ADediting_1282847	chr6_99473587_-	intronic
ADediting_1282848	chr6_99473590_-	intronic
ADediting_1282849	chr6_99473593_-	intronic
ADediting_1282850	chr6_99473599_-	intronic
ADediting_1282851	chr6_99473612_-	intronic
ADediting_1282852	chr6_99473633_-	intronic
ADediting_1282853	chr6_99473643_-	intronic
ADediting_1282854	chr6_99473672_-	intronic
ADediting_1282855	chr6_99473673_-	intronic
ADediting_1282856	chr6_99473679_-	intronic
ADediting_1282857	chr6_99473717_-	intronic
ADediting_1282858	chr6_99474289_-	intronic
ADediting_1282859	chr6_99474294_-	intronic
ADediting_1282860	chr6_99474295_-	intronic
ADediting_1282861	chr6_99474335_-	intronic
ADediting_1282862	chr6_99474358_-	intronic
ADediting_1282863	chr6_99474362_-	intronic
ADediting_1282864	chr6_99474397_-	intronic
ADediting_1282865	chr6_99474448_-	intronic
ADediting_1282866	chr6_99474449_-	intronic
ADediting_1282867	chr6_99474471_-	intronic
ADediting_1282868	chr6_99475384_-	intronic
ADediting_1282869	chr6_99475413_-	intronic
ADediting_1282870	chr6_99475427_-	intronic
ADediting_1282871	chr6_99475444_-	intronic
ADediting_1282872	chr6_99475453_-	intronic
ADediting_1282873	chr6_99475454_-	intronic
ADediting_1282874	chr6_99475467_-	intronic
ADediting_1282875	chr6_99475476_-	intronic
ADediting_1282876	chr6_99475480_-	intronic
ADediting_1282877	chr6_99475484_-	intronic
ADediting_1282878	chr6_99475489_-	intronic
ADediting_1282879	chr6_99475491_-	intronic
ADediting_1282880	chr6_99475493_-	intronic
ADediting_1282881	chr6_99475494_-	intronic
ADediting_1282882	chr6_99475495_-	intronic
ADediting_1282883	chr6_99475498_-	intronic
ADediting_1282884	chr6_99475509_-	intronic
ADediting_1282885	chr6_99475510_-	intronic
ADediting_1282886	chr6_99475566_-	intronic
ADediting_1282887	chr6_99475582_-	intronic
ADediting_1282888	chr6_99475589_-	intronic
ADediting_1282889	chr6_99475917_-	intronic
ADediting_1282890	chr6_99475953_-	intronic
ADediting_1282891	chr6_99475963_-	intronic
ADediting_1282892	chr6_99476016_-	intronic
ADediting_1282893	chr6_99476025_-	intronic
ADediting_1282894	chr6_99478740_-	intronic
ADediting_1282895	chr6_99484099_-	intronic
ADediting_1282896	chr6_99484279_-	intronic
ADediting_1282897	chr6_99484332_-	intronic
ADediting_1282898	chr6_99484350_-	intronic
ADediting_1282899	chr6_99484417_-	intronic
ADediting_1282900	chr6_99484605_-	intronic
ADediting_1282901	chr6_99484652_-	intronic
ADediting_1282902	chr6_99484705_-	intronic
ADediting_1282903	chr6_99489696_-	intronic
ADediting_1282904	chr6_99489702_-	intronic
ADediting_1282905	chr6_99489703_-	intronic
ADediting_1282906	chr6_99489712_-	intronic
ADediting_1282907	chr6_99489729_-	intronic
ADediting_1282908	chr6_99489755_-	intronic
ADediting_1282909	chr6_99489781_-	intronic
ADediting_1282910	chr6_99489829_-	intronic
ADediting_1282911	chr6_99489850_-	intronic
ADediting_1282912	chr6_99489851_-	intronic
ADediting_1282913	chr6_99489858_-	intronic
ADediting_1282914	chr6_99489864_-	intronic
ADediting_1282915	chr6_99489868_-	intronic
ADediting_1282916	chr6_99489869_-	intronic
ADediting_1282917	chr6_99489888_-	intronic
ADediting_1282918	chr6_99489899_-	intronic
ADediting_1282919	chr6_99489907_-	intronic
ADediting_1282920	chr6_99489937_-	intronic
ADediting_1282921	chr6_99489943_-	intronic
ADediting_1282922	chr6_99490198_-	intronic
ADediting_1282923	chr6_99490260_-	intronic
ADediting_1282924	chr6_99490261_-	intronic
ADediting_1282925	chr6_99490266_-	intronic
ADediting_1282926	chr6_99490269_-	intronic
ADediting_1282927	chr6_99490272_-	intronic
ADediting_1282928	chr6_99490285_-	intronic
ADediting_1282929	chr6_99490288_-	intronic
ADediting_1282930	chr6_99490301_-	intronic
ADediting_1282931	chr6_99490302_-	intronic
ADediting_1282932	chr6_99490312_-	intronic
ADediting_1282933	chr6_99490315_-	intronic
ADediting_1282934	chr6_99490393_-	intronic
ADediting_1282935	chr6_99490430_-	intronic
ADediting_1282936	chr6_99490447_-	intronic
ADediting_1282937	chr6_99490453_-	intronic
ADediting_1282938	chr6_99492633_-	intronic
ADediting_1282939	chr6_99494638_-	intronic
ADediting_1282940	chr6_99494650_-	intronic
ADediting_1282941	chr6_99494676_-	intronic
ADediting_1282942	chr6_99494702_-	intronic
ADediting_1282943	chr6_99494721_-	intronic
ADediting_1282944	chr6_99494728_-	intronic
ADediting_1282945	chr6_99494782_-	intronic
ADediting_1282946	chr6_99494810_-	intronic
ADediting_1282947	chr6_99494811_-	intronic
ADediting_1282948	chr6_99494812_-	intronic
ADediting_1282949	chr6_99494842_-	intronic
ADediting_1282950	chr6_99494850_-	intronic
ADediting_1282951	chr6_99503525_-	intronic
ADediting_1282952	chr6_99503558_-	intronic
ADediting_1282953	chr6_99506569_-	intronic
ADediting_1282954	chr6_99518777_-	intronic
ADediting_1584815	chr6_99433076_-	UTR3
ADediting_1584816	chr6_99436493_-	intronic
ADediting_1584817	chr6_99436499_-	intronic
ADediting_1584818	chr6_99436553_-	intronic
ADediting_1584819	chr6_99437019_-	intronic
ADediting_1584820	chr6_99437057_-	intronic
ADediting_1584821	chr6_99437091_-	intronic
ADediting_1584822	chr6_99437754_-	intronic
ADediting_1584823	chr6_99437755_-	intronic
ADediting_1584824	chr6_99437769_-	intronic
ADediting_1584825	chr6_99437808_-	intronic
ADediting_1584826	chr6_99437871_-	intronic
ADediting_1584827	chr6_99437876_-	intronic
ADediting_1584828	chr6_99437885_-	intronic
ADediting_1584829	chr6_99444172_-	intronic
ADediting_1584830	chr6_99444176_-	intronic
ADediting_1584831	chr6_99445339_-	intronic
ADediting_1584832	chr6_99459419_-	intronic
ADediting_1584833	chr6_99462811_-	exonic
ADediting_1584834	chr6_99462817_-	splicing
ADediting_1584835	chr6_99462862_-	intronic
ADediting_1584836	chr6_99462901_-	intronic
ADediting_1584837	chr6_99473576_-	intronic
ADediting_1584838	chr6_99474258_-	intronic
ADediting_1584839	chr6_99474391_-	intronic
ADediting_1584840	chr6_99475483_-	intronic
ADediting_1584841	chr6_99475921_-	intronic
ADediting_1584842	chr6_99475989_-	intronic
ADediting_1584843	chr6_99481794_-	intronic
ADediting_1663179	chr6_99446947_-	intronic
ADediting_1663180	chr6_99459322_-	intronic
ADediting_1663181	chr6_99459337_-	intronic
ADediting_1663182	chr6_99459370_-	intronic
ADediting_1663183	chr6_99459371_-	intronic
ADediting_1663184	chr6_99459414_-	intronic
ADediting_1663185	chr6_99462926_-	intronic
ADediting_1663186	chr6_99490334_-	intronic
ADediting_1663187	chr6_99493590_-	intronic
ADediting_1663188	chr6_99494772_-	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_1282771	chr6_99433064_-	SINE	Alu	Name=AluJb
ADediting_1282772	chr6_99433075_-	SINE	Alu	Name=AluJb
ADediting_1282773	chr6_99433084_-	SINE	Alu	Name=AluJb
ADediting_1282774	chr6_99436473_-	SINE	Alu	Name=AluSx1
ADediting_1282775	chr6_99436945_-	SINE	Alu	Name=AluSz6
ADediting_1282776	chr6_99437018_-	SINE	Alu	Name=AluSz6
ADediting_1282777	chr6_99437696_-	SINE	Alu	Name=AluSx1
ADediting_1282778	chr6_99437851_-	SINE	Alu	Name=AluSx1
ADediting_1282779	chr6_99437853_-	SINE	Alu	Name=AluSx1
ADediting_1282780	chr6_99437904_-	SINE	Alu	Name=AluSx1
ADediting_1282781	chr6_99444074_-	SINE	Alu	Name=AluJr
ADediting_1282782	chr6_99444080_-	SINE	Alu	Name=AluJr
ADediting_1282783	chr6_99444090_-	SINE	Alu	Name=AluJr
ADediting_1282784	chr6_99444150_-	SINE	Alu	Name=AluJr
ADediting_1282785	chr6_99444156_-	SINE	Alu	Name=AluJr
ADediting_1282786	chr6_99444214_-	SINE	Alu	Name=AluJr
ADediting_1282787	chr6_99444233_-	SINE	Alu	Name=AluJr
ADediting_1282788	chr6_99444281_-	SINE	Alu	Name=AluJr
ADediting_1282789	chr6_99444287_-	SINE	Alu	Name=AluJr
ADediting_1282790	chr6_99444288_-	SINE	Alu	Name=AluJr
ADediting_1282791	chr6_99444304_-	SINE	Alu	Name=AluJr
ADediting_1282792	chr6_99445228_-	SINE	Alu	Name=AluSg4
ADediting_1282793	chr6_99445233_-	SINE	Alu	Name=AluSg4
ADediting_1282794	chr6_99445361_-	SINE	Alu	Name=AluSg4
ADediting_1282795	chr6_99445420_-	SINE	Alu	Name=AluSg4
ADediting_1282796	chr6_99445421_-	SINE	Alu	Name=AluSg4
ADediting_1282797	chr6_99445436_-	SINE	Alu	Name=AluSg4
ADediting_1282798	chr6_99445447_-	SINE	Alu	Name=AluSg4
ADediting_1282799	chr6_99446951_-	SINE	Alu	Name=AluJr
ADediting_1282800	chr6_99446952_-	SINE	Alu	Name=AluJr
ADediting_1282801	chr6_99446963_-	SINE	Alu	Name=AluJr
ADediting_1282802	chr6_99446999_-	SINE	Alu	Name=AluJr
ADediting_1282803	chr6_99458157_-	SINE	Alu	Name=AluSc8
ADediting_1282804	chr6_99458209_-	SINE	Alu	Name=AluSc8
ADediting_1282805	chr6_99459205_-	LINE	L1	Name=L1PREC2
ADediting_1282806	chr6_99459215_-	LINE	L1	Name=L1PREC2
ADediting_1282807	chr6_99459229_-	LINE	L1	Name=L1PREC2
ADediting_1282808	chr6_99459232_-	LINE	L1	Name=L1PREC2
ADediting_1282809	chr6_99459302_-	LINE	L1	Name=L1PREC2
ADediting_1282810	chr6_99459316_-	LINE	L1	Name=L1PREC2
ADediting_1282811	chr6_99459317_-	LINE	L1	Name=L1PREC2
ADediting_1282812	chr6_99459340_-	LINE	L1	Name=L1PREC2
ADediting_1282813	chr6_99459570_-	LINE	L1	Name=L1PREC2
ADediting_1282814	chr6_99459584_-	LINE	L1	Name=L1PREC2
ADediting_1282815	chr6_99459597_-	LINE	L1	Name=L1PREC2
ADediting_1282816	chr6_99462780_-	SINE	Alu	Name=AluSz6
ADediting_1282817	chr6_99469702_-	SINE	Alu	Name=AluJb
ADediting_1282818	chr6_99472340_-	SINE	Alu	Name=AluSx
ADediting_1282819	chr6_99472344_-	SINE	Alu	Name=AluSx
ADediting_1282820	chr6_99472353_-	SINE	Alu	Name=AluSx
ADediting_1282821	chr6_99472354_-	SINE	Alu	Name=AluSx
ADediting_1282822	chr6_99472375_-	SINE	Alu	Name=AluSx
ADediting_1282823	chr6_99472376_-	SINE	Alu	Name=AluSx
ADediting_1282824	chr6_99472391_-	SINE	Alu	Name=AluSx
ADediting_1282825	chr6_99472394_-	SINE	Alu	Name=AluSx
ADediting_1282826	chr6_99472409_-	SINE	Alu	Name=AluSx
ADediting_1282827	chr6_99472489_-	SINE	Alu	Name=AluSx
ADediting_1282828	chr6_99473283_-	SINE	Alu	Name=AluSz
ADediting_1282829	chr6_99473295_-	SINE	Alu	Name=AluSz
ADediting_1282830	chr6_99473296_-	SINE	Alu	Name=AluSz
ADediting_1282831	chr6_99473318_-	SINE	Alu	Name=AluSz
ADediting_1282832	chr6_99473319_-	SINE	Alu	Name=AluSz
ADediting_1282833	chr6_99473322_-	SINE	Alu	Name=AluSz
ADediting_1282834	chr6_99473348_-	SINE	Alu	Name=AluSz
ADediting_1282835	chr6_99473368_-	SINE	Alu	Name=AluSz
ADediting_1282836	chr6_99473374_-	SINE	Alu	Name=AluSz
ADediting_1282837	chr6_99473377_-	SINE	Alu	Name=AluSz
ADediting_1282838	chr6_99473383_-	SINE	Alu	Name=AluSz
ADediting_1282839	chr6_99473425_-	SINE	Alu	Name=AluSz
ADediting_1282840	chr6_99473435_-	SINE	Alu	Name=AluSz
ADediting_1282841	chr6_99473437_-	SINE	Alu	Name=AluSz
ADediting_1282842	chr6_99473447_-	SINE	Alu	Name=AluSz
ADediting_1282843	chr6_99473464_-	SINE	Alu	Name=AluSz
ADediting_1282844	chr6_99473465_-	SINE	Alu	Name=AluSz
ADediting_1282845	chr6_99473485_-	SINE	Alu	Name=AluSz
ADediting_1282846	chr6_99473510_-	SINE	Alu	Name=AluSz
ADediting_1282847	chr6_99473587_-	SINE	Alu	Name=AluSx
ADediting_1282848	chr6_99473590_-	SINE	Alu	Name=AluSx
ADediting_1282849	chr6_99473593_-	SINE	Alu	Name=AluSx
ADediting_1282850	chr6_99473599_-	SINE	Alu	Name=AluSx
ADediting_1282851	chr6_99473612_-	SINE	Alu	Name=AluSx
ADediting_1282852	chr6_99473633_-	SINE	Alu	Name=AluSx
ADediting_1282853	chr6_99473643_-	SINE	Alu	Name=AluSx
ADediting_1282854	chr6_99473672_-	SINE	Alu	Name=AluSx
ADediting_1282855	chr6_99473673_-	SINE	Alu	Name=AluSx
ADediting_1282856	chr6_99473679_-	SINE	Alu	Name=AluSx
ADediting_1282857	chr6_99473717_-	SINE	Alu	Name=AluSx
ADediting_1282858	chr6_99474289_-	SINE	Alu	Name=AluSz
ADediting_1282859	chr6_99474294_-	SINE	Alu	Name=AluSz
ADediting_1282860	chr6_99474295_-	SINE	Alu	Name=AluSz
ADediting_1282861	chr6_99474335_-	SINE	Alu	Name=AluSz
ADediting_1282862	chr6_99474358_-	SINE	Alu	Name=AluSz
ADediting_1282863	chr6_99474362_-	SINE	Alu	Name=AluSz
ADediting_1282864	chr6_99474397_-	SINE	Alu	Name=AluSz
ADediting_1282865	chr6_99474448_-	SINE	Alu	Name=AluSz
ADediting_1282866	chr6_99474449_-	SINE	Alu	Name=AluSz
ADediting_1282867	chr6_99474471_-	SINE	Alu	Name=AluSz
ADediting_1282868	chr6_99475384_-	SINE	Alu	Name=AluSx
ADediting_1282869	chr6_99475413_-	SINE	Alu	Name=AluSx
ADediting_1282870	chr6_99475427_-	SINE	Alu	Name=AluSx
ADediting_1282871	chr6_99475444_-	SINE	Alu	Name=AluSx
ADediting_1282872	chr6_99475453_-	SINE	Alu	Name=AluSx
ADediting_1282873	chr6_99475454_-	SINE	Alu	Name=AluSx
ADediting_1282874	chr6_99475467_-	SINE	Alu	Name=AluSx
ADediting_1282875	chr6_99475476_-	SINE	Alu	Name=AluSx
ADediting_1282876	chr6_99475480_-	SINE	Alu	Name=AluSx
ADediting_1282877	chr6_99475484_-	SINE	Alu	Name=AluSx
ADediting_1282878	chr6_99475489_-	SINE	Alu	Name=AluSx
ADediting_1282879	chr6_99475491_-	SINE	Alu	Name=AluSx
ADediting_1282880	chr6_99475493_-	SINE	Alu	Name=AluSx
ADediting_1282881	chr6_99475494_-	SINE	Alu	Name=AluSx
ADediting_1282882	chr6_99475495_-	SINE	Alu	Name=AluSx
ADediting_1282883	chr6_99475498_-	SINE	Alu	Name=AluSx
ADediting_1282884	chr6_99475509_-	SINE	Alu	Name=AluSx
ADediting_1282885	chr6_99475510_-	SINE	Alu	Name=AluSx
ADediting_1282886	chr6_99475566_-	SINE	Alu	Name=AluSx
ADediting_1282887	chr6_99475582_-	SINE	Alu	Name=AluSx
ADediting_1282888	chr6_99475589_-	SINE	Alu	Name=AluSx
ADediting_1282889	chr6_99475917_-	SINE	Alu	Name=AluSx
ADediting_1282890	chr6_99475953_-	SINE	Alu	Name=AluSx
ADediting_1282891	chr6_99475963_-	SINE	Alu	Name=AluSx
ADediting_1282892	chr6_99476016_-	SINE	Alu	Name=AluSx
ADediting_1282893	chr6_99476025_-	SINE	Alu	Name=AluSx
ADediting_1282894	chr6_99478740_-	LINE	L1	Name=L1PA16
ADediting_1282895	chr6_99484099_-	SINE	Alu	Name=FLAM_A
ADediting_1282896	chr6_99484279_-	SINE	Alu	Name=AluJr4
ADediting_1282897	chr6_99484332_-	SINE	Alu	Name=AluJr4
ADediting_1282898	chr6_99484350_-	SINE	Alu	Name=AluJr4
ADediting_1282899	chr6_99484417_-	SINE	Alu	Name=AluJr4
ADediting_1282900	chr6_99484605_-	SINE	Alu	Name=AluJr
ADediting_1282901	chr6_99484652_-	SINE	Alu	Name=AluJr
ADediting_1282902	chr6_99484705_-	SINE	Alu	Name=AluJr
ADediting_1282903	chr6_99489696_-	SINE	Alu	Name=AluSz
ADediting_1282904	chr6_99489702_-	SINE	Alu	Name=AluSz
ADediting_1282905	chr6_99489703_-	SINE	Alu	Name=AluSz
ADediting_1282906	chr6_99489712_-	SINE	Alu	Name=AluSz
ADediting_1282907	chr6_99489729_-	SINE	Alu	Name=AluSz
ADediting_1282908	chr6_99489755_-	SINE	Alu	Name=AluSz
ADediting_1282909	chr6_99489781_-	SINE	Alu	Name=AluSz
ADediting_1282910	chr6_99489829_-	SINE	Alu	Name=AluSz
ADediting_1282911	chr6_99489850_-	SINE	Alu	Name=AluSz
ADediting_1282912	chr6_99489851_-	SINE	Alu	Name=AluSz
ADediting_1282913	chr6_99489858_-	SINE	Alu	Name=AluSz
ADediting_1282914	chr6_99489864_-	SINE	Alu	Name=AluSz
ADediting_1282915	chr6_99489868_-	SINE	Alu	Name=AluSz
ADediting_1282916	chr6_99489869_-	SINE	Alu	Name=AluSz
ADediting_1282917	chr6_99489888_-	SINE	Alu	Name=AluSz
ADediting_1282918	chr6_99489899_-	SINE	Alu	Name=AluSz
ADediting_1282919	chr6_99489907_-	SINE	Alu	Name=AluSz
ADediting_1282920	chr6_99489937_-	SINE	Alu	Name=AluSz
ADediting_1282921	chr6_99489943_-	SINE	Alu	Name=AluSz
ADediting_1282922	chr6_99490198_-	SINE	Alu	Name=AluSx1
ADediting_1282923	chr6_99490260_-	SINE	Alu	Name=AluSx1
ADediting_1282924	chr6_99490261_-	SINE	Alu	Name=AluSx1
ADediting_1282925	chr6_99490266_-	SINE	Alu	Name=AluSx1
ADediting_1282926	chr6_99490269_-	SINE	Alu	Name=AluSx1
ADediting_1282927	chr6_99490272_-	SINE	Alu	Name=AluSx1
ADediting_1282928	chr6_99490285_-	SINE	Alu	Name=AluSx1
ADediting_1282929	chr6_99490288_-	SINE	Alu	Name=AluSx1
ADediting_1282930	chr6_99490301_-	SINE	Alu	Name=AluSx1
ADediting_1282931	chr6_99490302_-	SINE	Alu	Name=AluSx1
ADediting_1282932	chr6_99490312_-	SINE	Alu	Name=AluSx1
ADediting_1282933	chr6_99490315_-	SINE	Alu	Name=AluSx1
ADediting_1282934	chr6_99490393_-	SINE	Alu	Name=AluSx1
ADediting_1282935	chr6_99490430_-	SINE	Alu	Name=AluSx1
ADediting_1282936	chr6_99490447_-	SINE	Alu	Name=AluSx1
ADediting_1282937	chr6_99490453_-	SINE	Alu	Name=AluSx1
ADediting_1282938	chr6_99492633_-	SINE	Alu	Name=AluSz
ADediting_1282939	chr6_99494638_-	SINE	Alu	Name=AluSz
ADediting_1282940	chr6_99494650_-	SINE	Alu	Name=AluSz
ADediting_1282941	chr6_99494676_-	SINE	Alu	Name=AluSz
ADediting_1282942	chr6_99494702_-	SINE	Alu	Name=AluSz
ADediting_1282943	chr6_99494721_-	SINE	Alu	Name=AluSz
ADediting_1282944	chr6_99494728_-	SINE	Alu	Name=AluSz
ADediting_1282945	chr6_99494782_-	SINE	Alu	Name=AluSz
ADediting_1282946	chr6_99494810_-	SINE	Alu	Name=AluSz
ADediting_1282947	chr6_99494811_-	SINE	Alu	Name=AluSz
ADediting_1282948	chr6_99494812_-	SINE	Alu	Name=AluSz
ADediting_1282949	chr6_99494842_-	SINE	Alu	Name=AluSz
ADediting_1282950	chr6_99494850_-	SINE	Alu	Name=AluSz
ADediting_1282951	chr6_99503525_-	SINE	Alu	Name=AluSg
ADediting_1282952	chr6_99503558_-	SINE	Alu	Name=AluSg
ADediting_1282953	chr6_99506569_-	SINE	Alu	Name=AluSz
ADediting_1282954	chr6_99518777_-	SINE	Alu	Name=AluSx1
ADediting_1584815	chr6_99433076_-	SINE	Alu	Name=AluJb
ADediting_1584816	chr6_99436493_-	SINE	Alu	Name=AluSx1
ADediting_1584817	chr6_99436499_-	SINE	Alu	Name=AluSx1
ADediting_1584818	chr6_99436553_-	SINE	Alu	Name=AluSx1
ADediting_1584819	chr6_99437019_-	SINE	Alu	Name=AluSz6
ADediting_1584820	chr6_99437057_-	SINE	Alu	Name=AluSz6
ADediting_1584821	chr6_99437091_-	SINE	Alu	Name=AluSz6
ADediting_1584822	chr6_99437754_-	SINE	Alu	Name=AluSx1
ADediting_1584823	chr6_99437755_-	SINE	Alu	Name=AluSx1
ADediting_1584824	chr6_99437769_-	SINE	Alu	Name=AluSx1
ADediting_1584825	chr6_99437808_-	SINE	Alu	Name=AluSx1
ADediting_1584826	chr6_99437871_-	SINE	Alu	Name=AluSx1
ADediting_1584827	chr6_99437876_-	SINE	Alu	Name=AluSx1
ADediting_1584828	chr6_99437885_-	SINE	Alu	Name=AluSx1
ADediting_1584829	chr6_99444172_-	SINE	Alu	Name=AluJr
ADediting_1584830	chr6_99444176_-	SINE	Alu	Name=AluJr
ADediting_1584831	chr6_99445339_-	SINE	Alu	Name=AluSg4
ADediting_1584832	chr6_99459419_-	LINE	L1	Name=L1PREC2
ADediting_1584833	chr6_99462811_-	SINE	Alu	Name=AluSz6
ADediting_1584834	chr6_99462817_-	SINE	Alu	Name=AluSz6
ADediting_1584835	chr6_99462862_-	SINE	Alu	Name=AluSz6
ADediting_1584836	chr6_99462901_-	SINE	Alu	Name=AluSz6
ADediting_1584837	chr6_99473576_-	SINE	Alu	Name=AluSx
ADediting_1584838	chr6_99474258_-	SINE	Alu	Name=AluSz
ADediting_1584839	chr6_99474391_-	SINE	Alu	Name=AluSz
ADediting_1584840	chr6_99475483_-	SINE	Alu	Name=AluSx
ADediting_1584841	chr6_99475921_-	SINE	Alu	Name=AluSx
ADediting_1584842	chr6_99475989_-	SINE	Alu	Name=AluSx
ADediting_1584843	chr6_99481794_-	LINE	L1	Name=L1PA16
ADediting_1663179	chr6_99446947_-	SINE	Alu	Name=AluJr
ADediting_1663180	chr6_99459322_-	LINE	L1	Name=L1PREC2
ADediting_1663181	chr6_99459337_-	LINE	L1	Name=L1PREC2
ADediting_1663182	chr6_99459370_-	LINE	L1	Name=L1PREC2
ADediting_1663183	chr6_99459371_-	LINE	L1	Name=L1PREC2
ADediting_1663184	chr6_99459414_-	LINE	L1	Name=L1PREC2
ADediting_1663185	chr6_99462926_-	SINE	Alu	Name=AluSz6
ADediting_1663186	chr6_99490334_-	SINE	Alu	Name=AluSx1
ADediting_1663187	chr6_99493590_-	SINE	Alu	Name=AluSq2
ADediting_1663188	chr6_99494772_-	SINE	Alu	Name=AluSz

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RNA A-to-I editing events in the alternative splicing sites for USP45

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	ADeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	ADediting_1282778	chr6_99437851_-	99437851:99437859	5ss	6i	AAGGTAAAA	8.38	AAGGTAAAG	9.06
ES	ADediting_1282779	chr6_99437853_-	99437851:99437859	5ss	4i	AAGGTAAAA	8.38	AAGGTAGAA	6.33

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for USP45

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

Top

Protein coding region RNA A-to-I editings for USP45

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for USP45

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1282771

chr6_99433064_-

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-4284

chr6

99433061

99433068

8mer-1a

99433061

99433078

154

-19.91

ADediting_1282771

chr6_99433064_-

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-4284

chr6

99433061

99433068

8mer-1a

99433061

99433078

154

-19.91

ADediting_1282772

chr6_99433075_-

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-3620-3p

chr6

99433071

99433077

7mer-m8

99433070

99433092

151

-19.69

ADediting_1282772

chr6_99433075_-

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-4732-3p

chr6

99433073

99433079

7mer-m8

99433072

99433090

157

-26.41

ADediting_1282772

chr6_99433075_-

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-3620-3p

chr6

99433071

99433077

7mer-m8

99433070

99433092

151

-19.69

ADediting_1282772

chr6_99433075_-

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-4732-3p

chr6

99433073

99433079

7mer-m8

99433072

99433090

157

-26.41

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1282771	chr6_99433064_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-218-2-3p	chr6	99433060	99433066	7mer-m8	99433059	99433077	147	-20.69
ADediting_1282771	chr6_99433064_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-218-2-3p	chr6	99433060	99433066	7mer-m8	99433059	99433077	147	-20.69
ADediting_1282772	chr6_99433075_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-10397-5p	chr6	99433073	99433079	7mer-m8	99433072	99433095	155	-22.65
ADediting_1282772	chr6_99433075_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-10397-5p	chr6	99433073	99433079	7mer-m8	99433072	99433095	155	-22.65
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-10400-3p	chr6	99433084	99433090	7mer-m8	99433083	99433104	141	-20.37
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-1343-3p	chr6	99433081	99433087	7mer-m8	99433080	99433101	148	-24.34
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-4674	chr6	99433084	99433090	7mer-m8	99433083	99433103	147	-24.2
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-6783-3p	chr6	99433081	99433087	7mer-m8	99433080	99433102	153	-22.57
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-939-3p	chr6	99433081	99433088	8mer-1a	99433081	99433105	146	-27.77
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-10400-3p	chr6	99433084	99433090	7mer-m8	99433083	99433104	141	-20.37
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-1343-3p	chr6	99433081	99433087	7mer-m8	99433080	99433101	148	-24.34
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-4674	chr6	99433084	99433090	7mer-m8	99433083	99433103	147	-24.2
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-6783-3p	chr6	99433081	99433087	7mer-m8	99433080	99433102	153	-22.57
ADediting_1282773	chr6_99433084_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-939-3p	chr6	99433081	99433088	8mer-1a	99433081	99433105	146	-27.77
ADediting_1584815	chr6_99433076_-	ENSG00000123552.17	ENST00000327681.10	USP45-201	hsa-miR-10397-5p	chr6	99433073	99433079	7mer-m8	99433072	99433095	155	-22.65
ADediting_1584815	chr6_99433076_-	ENSG00000123552.17	ENST00000500704.6	USP45-208	hsa-miR-10397-5p	chr6	99433073	99433079	7mer-m8	99433072	99433095	155	-22.65

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1471003

chr9_63819626_+

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-4477b

chr6

99435600

99435607

8mer-1a

99435600

99435620

157

-13.16

ADediting_1471003

chr9_63819626_+

ENSG00000123552.17

ENST00000369233.6

USP45-204

hsa-miR-4477b

chr6

99435600

99435607

8mer-1a

99435600

99435620

157

-13.16

ADediting_1471003

chr9_63819626_+

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-4477b

chr6

99435600

99435607

8mer-1a

99435600

99435620

157

-13.16

ADediting_843620

chr2_207754818_+

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-4775

chr6

99435164

99435170

7mer-m8

99435163

99435184

149

-10.53

ADediting_843620

chr2_207754818_+

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-4775

chr6

99435164

99435170

7mer-m8

99435163

99435184

149

-10.53

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1337757

chr7_5495852_-

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-589-3p

chr6

99434047

99434053

7mer-m8

99434046

99434070

151

-21.91

ADediting_1337757

chr7_5495852_-

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-589-3p

chr6

99434047

99434053

7mer-m8

99434046

99434070

151

-21.91

ADediting_1535951

chr14_100874558_+

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-337-3p

chr6

99434807

99434813

7mer-m8

99434806

99434831

153

-16.16

ADediting_1535951

chr14_100874558_+

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-337-3p

chr6

99434807

99434813

7mer-m8

99434806

99434831

153

-16.16

ADediting_1596844

chr1_162342605_+

ENSG00000123552.17

ENST00000327681.10

USP45-201

hsa-miR-556-3p

chr6

99434195

99434201

7mer-m8

99434194

99434215

143

-6.63

ADediting_1596844

chr1_162342605_+

ENSG00000123552.17

ENST00000500704.6

USP45-208

hsa-miR-556-3p

chr6

99434195

99434201

7mer-m8

99434194

99434215

143

-6.63

ADediting_843620

chr2_207754818_+

ENSG00000123552.17

ENST00000329966.10

USP45-202

hsa-miR-4775

chr6

99482530

99482536

7mer-1a

99482530

99482552

149

-13.13

ADediting_843620

chr2_207754818_+

ENSG00000123552.17

ENST00000329966.10

USP45-202

hsa-miR-4775

chr6

99482594

99482600

7mer-m8

99482593

99482614

141

-3.18

ADediting_843620

chr2_207754818_+

ENSG00000123552.17

ENST00000472914.6

USP45-205

hsa-miR-4775

chr6

99482530

99482536

7mer-1a

99482530

99482552

149

-13.13

ADediting_843620

chr2_207754818_+

ENSG00000123552.17

ENST00000472914.6

USP45-205

hsa-miR-4775

chr6

99482594

99482600

7mer-m8

99482593

99482614

141

-3.18

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for USP45

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000500704.6	protein_coding
ENST00000327681.10	protein_coding
ENST00000511403.5	protein_coding
ENST00000496090.6	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1282771	ENST00000500704.6	chr6_99433064_-	5141	-1397.60	-1397.30	-1403.70
ADediting_1282772	ENST00000500704.6	chr6_99433075_-	5130	-1399.40	-1397.30	-1403.70
ADediting_1584815	ENST00000500704.6	chr6_99433076_-	5129	-1398.30	-1397.30	-1403.70
ADediting_1282773	ENST00000500704.6	chr6_99433084_-	5121	-1397.90	-1397.30	-1403.70
ADediting_1282771	ENST00000327681.10	chr6_99433064_-	5630	-1613.80	-1611.90	-1618.20
ADediting_1282772	ENST00000327681.10	chr6_99433075_-	5619	-1615.50	-1611.90	-1618.20
ADediting_1584815	ENST00000327681.10	chr6_99433076_-	5618	-1613.00	-1611.90	-1618.20
ADediting_1282773	ENST00000327681.10	chr6_99433084_-	5610	-1613.80	-1611.90	-1618.20
ADediting_1282816	ENST00000511403.5	chr6_99462780_-	438	-160.20	-160.90	-161.10
ADediting_1584833	ENST00000511403.5	chr6_99462811_-	407	-161.80	-160.90	-161.10
ADediting_1282816	ENST00000496090.6	chr6_99462780_-	476	-148.30	-147.40	-149.10
ADediting_1584833	ENST00000496090.6	chr6_99462811_-	445	-149.80	-147.40	-149.10

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for USP45

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_1282771	chr6_99433064_-	7.96709587674304e-07	0.390207092211093	9.63982902304086e-13	0.540270190865358	0.000586040158603069	0.27749863168658
CER	ADediting_1282772	chr6_99433075_-	0.0336721097459859	0.173555494095338	5.79064388676509e-05	0.322222993274206	0.0380805498175833	0.169530720545548
CER	ADediting_1282773	chr6_99433084_-	6.68734521192269e-06	0.358408665279276	1.08627476068721e-12	0.539227045776121	0.000107424779880635	0.310967892193448
CER	ADediting_1282775	chr6_99436945_-	1.52813172197722e-05	0.345080013590605	3.08059984091382e-09	0.460357576192338	0.666526081745199	0.0354701708622407
CER	ADediting_1282776	chr6_99437018_-	3.8432224539138e-07	0.400376713129243	1.30488182886393e-08	0.443603137639423	0.622549466128145	0.0405136613330785
CER	ADediting_1282779	chr6_99437853_-	0.00763022386974248	0.217054364102783	1.40422509208894e-05	0.346471897227841	0.283574173025273	0.0881216765527576
CER	ADediting_1282780	chr6_99437904_-	1.22776035207563e-11	0.517235735066917	1.58745069064866e-11	0.514810349699099	0.676119884347005	0.0343878425493928
DLPFC	ADediting_1282836	chr6_99473374_-	0.0799415743807593	0.0996064727203015	0.795976177303579	0.0147438795103212	3.21908847308769e-14	0.413284165053748
DLPFC	ADediting_1282847	chr6_99473587_-	0.234879788471178	0.0676631778413762	0.887626338347697	-0.00805819893520082	3.28906152513013e-12	0.38201303051705
DLPFC	ADediting_1282848	chr6_99473590_-	0.333791987258679	0.0550745591000378	0.531755676241785	-0.035648977263152	4.35167135659116e-10	0.344914367765876
DLPFC	ADediting_1282849	chr6_99473593_-	0.145755196624271	0.0828133896889802	0.962300839455741	0.00269544000082934	2.10480835345575e-10	0.350743011299844
DLPFC	ADediting_1282851	chr6_99473612_-	0.0777587598040074	0.100331825042963	0.733534300011171	0.0194116024282263	2.45186458739895e-09	0.33053468943728
DLPFC	ADediting_1282852	chr6_99473633_-	0.0832145635700257	0.098548297234201	0.888239866917795	-0.00801391328116423	2.64475675435379e-12	0.383563176099506
DLPFC	ADediting_1282853	chr6_99473643_-	0.152523145593059	0.0814509007397998	0.706439459017502	-0.0214761351835202	7.0069885988884e-15	0.422912184067548
DLPFC	ADediting_1282854	chr6_99473672_-	0.851397147275879	-0.0106828259608002	0.0500483616246353	-0.111398374357772	5.2092586131042e-14	0.41017961038301
DLPFC	ADediting_1282855	chr6_99473673_-	0.866645688633568	-0.00957571811132737	0.0436891852941228	-0.11464649164543	1.25949137258415e-15	0.433393623954795
DLPFC	ADediting_1282856	chr6_99473679_-	0.238210419067903	-0.0671851849688398	0.00989249849098954	-0.14631123356985	6.92883929324386e-11	0.359434740028254
DLPFC	ADediting_1282863	chr6_99474362_-	0.183070440284912	0.0758135935340361	0.740701124227676	0.0188698339115017	5.5753102930486e-10	0.342898138788745
DLPFC	ADediting_1282887	chr6_99475582_-	0.817604545396181	0.0131512982152665	0.0931012933873711	-0.0955432563238612	2.18417754152666e-08	0.311202873026493
CER	ADediting_1584815	chr6_99433076_-	0.00615865400946642	0.222702847350321	4.09959809902745e-06	0.366026759284079	0.00974379501993258	0.21043896848901
CER	ADediting_1584820	chr6_99437057_-	0.00385129341721124	0.234634432490058	6.60876333716163e-06	0.358595011563086	0.108802244809141	0.131464233065856
CER	ADediting_1584821	chr6_99437091_-	0.000169953550839347	0.302311778520395	4.65750933040306e-07	0.397728712758828	0.866343541763674	0.0138572878416433
CER	ADediting_1584824	chr6_99437769_-	0.00015030225932053	0.30465685043116	3.13389399946859e-06	0.370127360222367	0.88260482440411	-0.0121583022612399
CER	ADediting_1584826	chr6_99437871_-	1.03009289855881e-08	0.446410252886015	2.06216391538756e-10	0.489498347373067	0.302597956527039	0.0847281775424651
CER	ADediting_1584828	chr6_99437885_-	3.38942913285739e-07	0.402095776121524	1.23774370703228e-09	0.470493087164334	0.301422693446775	0.0849336577633713

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	4.23145776134843e-10	0.345141406888679	0.000116990657056315	0.217061279648163	0.269839550491768	-0.0628626813337344
AC	1.61191242919853e-07	0.324004009882882	0.000483358245841588	0.219124880593265	7.25708814086126e-07	0.307267666735481
PCC	1.27087083953299e-06	0.342128053615917	1.88903905047137e-05	0.304149406101876	0.000608396941259868	0.24582659233768
CER	7.40488749077662e-42	0.84387609511097	3.41216835288774e-22	0.686045001470135	0.354203753076387	0.0761728947772128
TCX	4.33192124332732e-26	0.7285094014034	9.73576232941784e-13	0.540183838772407	0.000104646151307064	0.31145440581148
FP	6.53519137277287e-10	0.442025813679032	3.17097029021612e-18	0.592138161912105	0.822360939131324	-0.0169458721832453
PG	1.98123407829634e-39	0.780749534462715	8.71845698468577e-25	0.661610406164084	0.310315065375554	-0.0747911758799143
STG	4.01056964145576e-13	0.689690770416945	1.61149433133057e-12	0.676625978786361	0.860939119278415	-0.0194025051057667

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Relation with AD stages for USP45

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_1282771	chr6_99433064_-	3.34461070214718e-06	0.4303329103355
CER	ADediting_1282773	chr6_99433084_-	7.43172253428088e-07	0.455207495496806
CER	ADediting_1282776	chr6_99437018_-	0.000915142649484118	0.314546007647044
CER	ADediting_1584815	chr6_99433076_-	8.17526523067416e-05	0.369823488707998

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
TCX	1.09840674863738e-05	0.412751448271924

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RelatedDrugs for USP45

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for USP45

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Landscape

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Contact

Gene summary for USP45

RNA A-to-I events for USP45

RNA editing positional annotations for USP45 using Annovar

RNA A-to-I editing events in the alternative splicing sites for USP45

Differntial gene expression between RNA A-to-I edited versus non-edited samples for USP45

Protein coding region RNA A-to-I editings for USP45

The effects of the RNA editing to the miRNA binding sites for USP45

The effects of the RNA editing to the stability of the RNA structures for USP45

Relation with ADAR for USP45

Relation with AD stages for USP45

RelatedDrugs for USP45

RelatedDiseases for USP45

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene