|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for TMTC4 |
 Gene summary |
| Gene information | Gene symbol | TMTC4 | Gene ID | 84899 |
| Gene name | transmembrane O-mannosyltransferase targeting cadherins 4 | |
| Synonyms | - | |
| Cytomap | 13q32.3 | |
| Type of gene | protein-coding | |
| Description | protein O-mannosyl-transferase TMTC4transmembrane and TPR repeat-containing protein 4transmembrane and tetratricopeptide repeat containing 4 | |
| Modification date | 20200313 | |
| UniProtAcc | Q5T4D3, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for TMTC4 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_380827(100623262, -), ADediting_380828(100623268, -), ADediting_380829(100623270, -), ADediting_380830(100623271, -), ADediting_380831(100623318, -), ADediting_380832(100623329, -), ADediting_380833(100623330, -), ADediting_380834(100623335, -), ADediting_380835(100623344, -), ADediting_380836(100623370, -), ADediting_380837(100623371, -), ADediting_380838(100623391, -), ADediting_380839(100623393, -), ADediting_380840(100623400, -), ADediting_380841(100623401, -), ADediting_380842(100623403, -), ADediting_380843(100623408, -), ADediting_380844(100623409, -), ADediting_380845(100623410, -), ADediting_380846(100623411, -), ADediting_380847(100623415, -), ADediting_380848(100623426, -), ADediting_380849(100623428, -), ADediting_380850(100623434, -), ADediting_380851(100623436, -), ADediting_380852(100623437, -), ADediting_380853(100623451, -), ADediting_380854(100623452, -), ADediting_380855(100623457, -), ADediting_380856(100623460, -), ADediting_380857(100623483, -), ADediting_380858(100623484, -), ADediting_380859(100623489, -), ADediting_380860(100623497, -), ADediting_380861(100623505, -), ADediting_380862(100623506, -), ADediting_380863(100623512, -), ADediting_380864(100623522, -), ADediting_380865(100623938, -), ADediting_380866(100623971, -), ADediting_380867(100624054, -), ADediting_380868(100624064, -), ADediting_380869(100624070, -), ADediting_380870(100624082, -), ADediting_380871(100624092, -), ADediting_380872(100624123, -), ADediting_380873(100624133, -), ADediting_380874(100624137, -), ADediting_380875(100624145, -), ADediting_380876(100624159, -), ADediting_380877(100624162, -), ADediting_380878(100624168, -), ADediting_380879(100624204, -), ADediting_380880(100624226, -), ADediting_380881(100624263, -), ADediting_380882(100624315, -), ADediting_380883(100624320, -), ADediting_380884(100624328, -), ADediting_380885(100624340, -), ADediting_380886(100639705, -), ADediting_380887(100639714, -), ADediting_380888(100641560, -), ADediting_380889(100641561, -), ADediting_380890(100641599, -), ADediting_380891(100641612, -), ADediting_380892(100641616, -), ADediting_380893(100641628, -), ADediting_380894(100641641, -), ADediting_380895(100641648, -), ADediting_380896(100641652, -), ADediting_380897(100641681, -), ADediting_380898(100641704, -), ADediting_380899(100641737, -), ADediting_380900(100641775, -), ADediting_380901(100652331, -), ADediting_380902(100655224, -), ADediting_380903(100655231, -), ADediting_380904(100655268, -), ADediting_380905(100660072, -), ADediting_380906(100660096, -), ADediting_380907(100660236, -), ADediting_380908(100660249, -), ADediting_380909(100660255, -), ADediting_1534573(100623412, -), ADediting_1534574(100624084, -), ADediting_1534575(100624338, -), ADediting_1534576(100670757, -), ADediting_1534577(100672639, -), ADediting_1534578(100672748, -), ADediting_1534579(100672771, -), ADediting_1615709(100624202, -), ADediting_1615710(100624244, -), ADediting_1615711(100660215, -), |
Top |
RNA editing positional annotations for TMTC4 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_380827 | chr13_100623262_- | intronic |
| ADediting_380828 | chr13_100623268_- | intronic |
| ADediting_380829 | chr13_100623270_- | intronic |
| ADediting_380830 | chr13_100623271_- | intronic |
| ADediting_380831 | chr13_100623318_- | intronic |
| ADediting_380832 | chr13_100623329_- | intronic |
| ADediting_380833 | chr13_100623330_- | intronic |
| ADediting_380834 | chr13_100623335_- | intronic |
| ADediting_380835 | chr13_100623344_- | intronic |
| ADediting_380836 | chr13_100623370_- | intronic |
| ADediting_380837 | chr13_100623371_- | intronic |
| ADediting_380838 | chr13_100623391_- | intronic |
| ADediting_380839 | chr13_100623393_- | intronic |
| ADediting_380840 | chr13_100623400_- | intronic |
| ADediting_380841 | chr13_100623401_- | intronic |
| ADediting_380842 | chr13_100623403_- | intronic |
| ADediting_380843 | chr13_100623408_- | intronic |
| ADediting_380844 | chr13_100623409_- | intronic |
| ADediting_380845 | chr13_100623410_- | intronic |
| ADediting_380846 | chr13_100623411_- | intronic |
| ADediting_380847 | chr13_100623415_- | intronic |
| ADediting_380848 | chr13_100623426_- | intronic |
| ADediting_380849 | chr13_100623428_- | intronic |
| ADediting_380850 | chr13_100623434_- | intronic |
| ADediting_380851 | chr13_100623436_- | intronic |
| ADediting_380852 | chr13_100623437_- | intronic |
| ADediting_380853 | chr13_100623451_- | intronic |
| ADediting_380854 | chr13_100623452_- | intronic |
| ADediting_380855 | chr13_100623457_- | intronic |
| ADediting_380856 | chr13_100623460_- | intronic |
| ADediting_380857 | chr13_100623483_- | intronic |
| ADediting_380858 | chr13_100623484_- | intronic |
| ADediting_380859 | chr13_100623489_- | intronic |
| ADediting_380860 | chr13_100623497_- | intronic |
| ADediting_380861 | chr13_100623505_- | intronic |
| ADediting_380862 | chr13_100623506_- | intronic |
| ADediting_380863 | chr13_100623512_- | intronic |
| ADediting_380864 | chr13_100623522_- | intronic |
| ADediting_380865 | chr13_100623938_- | ncRNA_exonic |
| ADediting_380866 | chr13_100623971_- | ncRNA_exonic |
| ADediting_380867 | chr13_100624054_- | ncRNA_intronic |
| ADediting_380868 | chr13_100624064_- | ncRNA_intronic |
| ADediting_380869 | chr13_100624070_- | ncRNA_intronic |
| ADediting_380870 | chr13_100624082_- | ncRNA_intronic |
| ADediting_380871 | chr13_100624092_- | ncRNA_intronic |
| ADediting_380872 | chr13_100624123_- | ncRNA_intronic |
| ADediting_380873 | chr13_100624133_- | ncRNA_intronic |
| ADediting_380874 | chr13_100624137_- | ncRNA_intronic |
| ADediting_380875 | chr13_100624145_- | ncRNA_intronic |
| ADediting_380876 | chr13_100624159_- | ncRNA_intronic |
| ADediting_380877 | chr13_100624162_- | ncRNA_intronic |
| ADediting_380878 | chr13_100624168_- | ncRNA_intronic |
| ADediting_380879 | chr13_100624204_- | ncRNA_intronic |
| ADediting_380880 | chr13_100624226_- | ncRNA_intronic |
| ADediting_380881 | chr13_100624263_- | ncRNA_intronic |
| ADediting_380882 | chr13_100624315_- | ncRNA_intronic |
| ADediting_380883 | chr13_100624320_- | ncRNA_intronic |
| ADediting_380884 | chr13_100624328_- | ncRNA_intronic |
| ADediting_380885 | chr13_100624340_- | ncRNA_intronic |
| ADediting_380886 | chr13_100639705_- | intronic |
| ADediting_380887 | chr13_100639714_- | intronic |
| ADediting_380888 | chr13_100641560_- | intronic |
| ADediting_380889 | chr13_100641561_- | intronic |
| ADediting_380890 | chr13_100641599_- | intronic |
| ADediting_380891 | chr13_100641612_- | intronic |
| ADediting_380892 | chr13_100641616_- | intronic |
| ADediting_380893 | chr13_100641628_- | intronic |
| ADediting_380894 | chr13_100641641_- | intronic |
| ADediting_380895 | chr13_100641648_- | intronic |
| ADediting_380896 | chr13_100641652_- | intronic |
| ADediting_380897 | chr13_100641681_- | intronic |
| ADediting_380898 | chr13_100641704_- | intronic |
| ADediting_380899 | chr13_100641737_- | intronic |
| ADediting_380900 | chr13_100641775_- | intronic |
| ADediting_380901 | chr13_100652331_- | intronic |
| ADediting_380902 | chr13_100655224_- | intronic |
| ADediting_380903 | chr13_100655231_- | intronic |
| ADediting_380904 | chr13_100655268_- | intronic |
| ADediting_380905 | chr13_100660072_- | intronic |
| ADediting_380906 | chr13_100660096_- | intronic |
| ADediting_380907 | chr13_100660236_- | intronic |
| ADediting_380908 | chr13_100660249_- | intronic |
| ADediting_380909 | chr13_100660255_- | intronic |
| ADediting_1534573 | chr13_100623412_- | intronic |
| ADediting_1534574 | chr13_100624084_- | ncRNA_intronic |
| ADediting_1534575 | chr13_100624338_- | ncRNA_intronic |
| ADediting_1534576 | chr13_100670757_- | intronic |
| ADediting_1534577 | chr13_100672639_- | intronic |
| ADediting_1534578 | chr13_100672748_- | intronic |
| ADediting_1534579 | chr13_100672771_- | intronic |
| ADediting_1615709 | chr13_100624202_- | ncRNA_intronic |
| ADediting_1615710 | chr13_100624244_- | ncRNA_intronic |
| ADediting_1615711 | chr13_100660215_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_380827 | chr13_100623262_- | SINE | Alu | Name=AluSz |
| ADediting_380828 | chr13_100623268_- | SINE | Alu | Name=AluSz |
| ADediting_380829 | chr13_100623270_- | SINE | Alu | Name=AluSz |
| ADediting_380830 | chr13_100623271_- | SINE | Alu | Name=AluSz |
| ADediting_380831 | chr13_100623318_- | SINE | Alu | Name=AluSz |
| ADediting_380832 | chr13_100623329_- | SINE | Alu | Name=AluSz |
| ADediting_380833 | chr13_100623330_- | SINE | Alu | Name=AluSz |
| ADediting_380834 | chr13_100623335_- | SINE | Alu | Name=AluSz |
| ADediting_380835 | chr13_100623344_- | SINE | Alu | Name=AluSz |
| ADediting_380836 | chr13_100623370_- | SINE | Alu | Name=AluSz |
| ADediting_380837 | chr13_100623371_- | SINE | Alu | Name=AluSz |
| ADediting_380838 | chr13_100623391_- | SINE | Alu | Name=AluSz |
| ADediting_380839 | chr13_100623393_- | SINE | Alu | Name=AluSz |
| ADediting_380840 | chr13_100623400_- | SINE | Alu | Name=AluSz |
| ADediting_380841 | chr13_100623401_- | SINE | Alu | Name=AluSz |
| ADediting_380842 | chr13_100623403_- | SINE | Alu | Name=AluSz |
| ADediting_380843 | chr13_100623408_- | SINE | Alu | Name=AluSz |
| ADediting_380844 | chr13_100623409_- | SINE | Alu | Name=AluSz |
| ADediting_380845 | chr13_100623410_- | SINE | Alu | Name=AluSz |
| ADediting_380846 | chr13_100623411_- | SINE | Alu | Name=AluSz |
| ADediting_380847 | chr13_100623415_- | SINE | Alu | Name=AluSz |
| ADediting_380848 | chr13_100623426_- | SINE | Alu | Name=AluSz |
| ADediting_380849 | chr13_100623428_- | SINE | Alu | Name=AluSz |
| ADediting_380850 | chr13_100623434_- | SINE | Alu | Name=AluSz |
| ADediting_380851 | chr13_100623436_- | SINE | Alu | Name=AluSz |
| ADediting_380852 | chr13_100623437_- | SINE | Alu | Name=AluSz |
| ADediting_380853 | chr13_100623451_- | SINE | Alu | Name=AluSz |
| ADediting_380854 | chr13_100623452_- | SINE | Alu | Name=AluSz |
| ADediting_380855 | chr13_100623457_- | SINE | Alu | Name=AluSz |
| ADediting_380856 | chr13_100623460_- | SINE | Alu | Name=AluSz |
| ADediting_380857 | chr13_100623483_- | SINE | Alu | Name=AluSz |
| ADediting_380858 | chr13_100623484_- | SINE | Alu | Name=AluSz |
| ADediting_380859 | chr13_100623489_- | SINE | Alu | Name=AluSz |
| ADediting_380860 | chr13_100623497_- | SINE | Alu | Name=AluSz |
| ADediting_380861 | chr13_100623505_- | SINE | Alu | Name=AluSz |
| ADediting_380862 | chr13_100623506_- | SINE | Alu | Name=AluSz |
| ADediting_380863 | chr13_100623512_- | SINE | Alu | Name=AluSz |
| ADediting_380864 | chr13_100623522_- | SINE | Alu | Name=AluSz |
| ADediting_380867 | chr13_100624054_- | SINE | Alu | Name=AluY |
| ADediting_380868 | chr13_100624064_- | SINE | Alu | Name=AluY |
| ADediting_380869 | chr13_100624070_- | SINE | Alu | Name=AluY |
| ADediting_380870 | chr13_100624082_- | SINE | Alu | Name=AluY |
| ADediting_380871 | chr13_100624092_- | SINE | Alu | Name=AluY |
| ADediting_380872 | chr13_100624123_- | SINE | Alu | Name=AluY |
| ADediting_380873 | chr13_100624133_- | SINE | Alu | Name=AluY |
| ADediting_380874 | chr13_100624137_- | SINE | Alu | Name=AluY |
| ADediting_380875 | chr13_100624145_- | SINE | Alu | Name=AluY |
| ADediting_380876 | chr13_100624159_- | SINE | Alu | Name=AluY |
| ADediting_380877 | chr13_100624162_- | SINE | Alu | Name=AluY |
| ADediting_380878 | chr13_100624168_- | SINE | Alu | Name=AluY |
| ADediting_380879 | chr13_100624204_- | SINE | Alu | Name=AluY |
| ADediting_380880 | chr13_100624226_- | SINE | Alu | Name=AluY |
| ADediting_380881 | chr13_100624263_- | SINE | Alu | Name=AluY |
| ADediting_380882 | chr13_100624315_- | SINE | Alu | Name=AluY |
| ADediting_380883 | chr13_100624320_- | SINE | Alu | Name=AluY |
| ADediting_380884 | chr13_100624328_- | SINE | Alu | Name=AluY |
| ADediting_380885 | chr13_100624340_- | SINE | Alu | Name=AluY |
| ADediting_380886 | chr13_100639705_- | SINE | Alu | Name=AluSq2 |
| ADediting_380887 | chr13_100639714_- | SINE | Alu | Name=AluSq2 |
| ADediting_380888 | chr13_100641560_- | SINE | Alu | Name=AluSp |
| ADediting_380889 | chr13_100641561_- | SINE | Alu | Name=AluSp |
| ADediting_380890 | chr13_100641599_- | SINE | Alu | Name=AluSp |
| ADediting_380891 | chr13_100641612_- | SINE | Alu | Name=AluSp |
| ADediting_380892 | chr13_100641616_- | SINE | Alu | Name=AluSp |
| ADediting_380893 | chr13_100641628_- | SINE | Alu | Name=AluSp |
| ADediting_380894 | chr13_100641641_- | SINE | Alu | Name=AluSp |
| ADediting_380895 | chr13_100641648_- | SINE | Alu | Name=AluSp |
| ADediting_380896 | chr13_100641652_- | SINE | Alu | Name=AluSp |
| ADediting_380897 | chr13_100641681_- | SINE | Alu | Name=AluSp |
| ADediting_380898 | chr13_100641704_- | SINE | Alu | Name=AluSp |
| ADediting_380899 | chr13_100641737_- | SINE | Alu | Name=AluSp |
| ADediting_380900 | chr13_100641775_- | SINE | Alu | Name=AluSp |
| ADediting_380901 | chr13_100652331_- | SINE | Alu | Name=AluSx1 |
| ADediting_380902 | chr13_100655224_- | SINE | Alu | Name=AluSz |
| ADediting_380903 | chr13_100655231_- | SINE | Alu | Name=AluSz |
| ADediting_380904 | chr13_100655268_- | SINE | Alu | Name=AluSz |
| ADediting_380905 | chr13_100660072_- | SINE | Alu | Name=AluSz |
| ADediting_380906 | chr13_100660096_- | SINE | Alu | Name=AluSz |
| ADediting_380907 | chr13_100660236_- | SINE | Alu | Name=AluSz |
| ADediting_380908 | chr13_100660249_- | SINE | Alu | Name=AluSz |
| ADediting_380909 | chr13_100660255_- | SINE | Alu | Name=AluSz |
| ADediting_1534573 | chr13_100623412_- | SINE | Alu | Name=AluSz |
| ADediting_1534574 | chr13_100624084_- | SINE | Alu | Name=AluY |
| ADediting_1534575 | chr13_100624338_- | SINE | Alu | Name=AluY |
| ADediting_1534576 | chr13_100670757_- | SINE | Alu | Name=AluJo |
| ADediting_1534577 | chr13_100672639_- | SINE | Alu | Name=AluJr |
| ADediting_1534578 | chr13_100672748_- | SINE | Alu | Name=AluJr |
| ADediting_1534579 | chr13_100672771_- | SINE | Alu | Name=AluJr |
| ADediting_1615709 | chr13_100624202_- | SINE | Alu | Name=AluY |
| ADediting_1615710 | chr13_100624244_- | SINE | Alu | Name=AluY |
| ADediting_1615711 | chr13_100660215_- | SINE | Alu | Name=AluSz |
Top |
RNA A-to-I editing events in the alternative splicing sites for TMTC4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMTC4 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
 | |
 | |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for TMTC4 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for TMTC4 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000125247.15 | ENST00000342624.9 | TMTC4-202 | hsa-miR-589-3p | chr13 | 100604355 | 100604362 | 8mer-1a | 100604355 | 100604378 | 142 | -17.55 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000125247.15 | ENST00000376234.7 | TMTC4-203 | hsa-miR-589-3p | chr13 | 100604355 | 100604362 | 8mer-1a | 100604355 | 100604378 | 142 | -17.55 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1556067 | chr19_40282625_- | ENSG00000125247.15 | ENST00000342624.9 | TMTC4-202 | hsa-miR-641 | chr13 | 100604745 | 100604751 | 7mer-m8 | 100604744 | 100604774 | 147 | -15.65 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000125247.15 | ENST00000376234.7 | TMTC4-203 | hsa-miR-641 | chr13 | 100604745 | 100604751 | 7mer-m8 | 100604744 | 100604774 | 147 | -15.65 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000125247.15 | ENST00000342624.9 | TMTC4-202 | hsa-miR-641 | chr13 | 100604745 | 100604751 | 7mer-m8 | 100604744 | 100604774 | 147 | -15.65 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000125247.15 | ENST00000376234.7 | TMTC4-203 | hsa-miR-641 | chr13 | 100604745 | 100604751 | 7mer-m8 | 100604744 | 100604774 | 147 | -15.65 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000125247.15 | ENST00000342624.9 | TMTC4-202 | hsa-miR-4775 | chr13 | 100603948 | 100603954 | 7mer-m8 | 100603947 | 100603969 | 148 | -3.57 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000125247.15 | ENST00000376234.7 | TMTC4-203 | hsa-miR-4775 | chr13 | 100603948 | 100603954 | 7mer-m8 | 100603947 | 100603969 | 148 | -3.57 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for TMTC4 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for TMTC4 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_380834 | chr13_100623335_- | 0.133838793323173 | 0.0853344593419819 | 0.885170118905929 | 0.00823554222632522 | 9.7967326011301e-11 | 0.356753587927189 |
| DLPFC | ADediting_380835 | chr13_100623344_- | 0.13531706519605 | 0.0850125824744073 | 0.801401419636232 | -0.0143433696302353 | 1.10679787618314e-10 | 0.355803121185518 |
| TCX | ADediting_380836 | chr13_100623370_- | 0.16100801639044 | 0.115029467490179 | 0.0692403312108574 | -0.148762964074102 | 1.5928431495936e-05 | 0.344394903928332 |
| TCX | ADediting_380851 | chr13_100623436_- | 0.128866333891095 | 0.124550751781735 | 0.070017590507324 | -0.148353940897516 | 0.000138085625273625 | 0.306263315823162 |
| DLPFC | ADediting_380876 | chr13_100624159_- | 0.0414519574594504 | 0.115884030168198 | 0.200394196180999 | 0.0729212280823345 | 7.11868947814125e-08 | 0.300153885866686 |
| DLPFC | ADediting_380891 | chr13_100641612_- | 0.993748752572585 | 0.000446794894409375 | 0.105202944387902 | -0.0921939440808838 | 9.60918101699447e-11 | 0.35690388371417 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 5.16940332357073e-38 | 0.64605639084853 | 3.43683336296622e-30 | 0.587787524930297 | 1.69857181137401e-05 | 0.241639542392337 |
| AC | 1.0369347658426e-46 | 0.751578242382945 | 5.88978855079036e-31 | 0.646293462208149 | 4.93992858246195e-28 | 0.620809115694731 |
| PCC | 1.45749493990069e-25 | 0.663107448538369 | 4.02489532153182e-23 | 0.636884333921187 | 4.01035322148487e-06 | 0.326579310980526 |
| CER | 3.53537720894568e-17 | 0.618141362082224 | 5.37267348573452e-05 | 0.323557672297274 | 0.495049893702675 | 0.0561351274447423 |
| TCX | 6.59503064511974e-06 | 0.358627791982321 | 0.0885323252109753 | -0.139551053538476 | 9.68066164994246e-18 | 0.626666962383329 |
| FP | 2.2703776989219e-08 | 0.403850677197993 | 1.90687421919049e-11 | 0.475862715701492 | 0.000518680354853742 | 0.25756758167229 |
| PG | 6.6165995388547e-19 | 0.591063743769992 | 1.50862650758488e-08 | 0.400268385053786 | 0.00147498768173745 | 0.231521524886875 |
| STG | 9.27142191589396e-08 | 0.543345056590762 | 0.000259657824263526 | 0.388566535453368 | 0.165508855742668 | 0.152709186073068 |
Top |
Relation with AD stages for TMTC4 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| STG | ADediting_380882 | chr13_100624315_- | 0.00530792248637142 | -0.301569016689878 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
Top |
RelatedDrugs for TMTC4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TMTC4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TMTC4 | C0006142 | Malignant neoplasm of breast | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|