ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for GTPBP3

Gene summary

Gene information	Gene symbol	GTPBP3
	Gene ID	84705
	Gene name	GTP binding protein 3, mitochondrial
	Synonyms	COXPD23\|GTPBG3\|MSS1\|MTGP1\|THDF1
	Cytomap	19p13.11
	Type of gene	protein-coding
	Description	tRNA modification GTPase GTPBP3, mitochondrialmitochondrial GTP-binding protein 1
	Modification date	20200313
	UniProtAcc	Q969Y2,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for GTPBP3

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_720729(17342183, +), ADediting_720730(17342203, +), ADediting_720731(17342204, +), ADediting_720732(17342291, +), ADediting_720733(17342354, +), ADediting_720734(17342367, +), ADediting_720735(17342368, +), ADediting_720736(17342397, +), ADediting_720737(17342433, +), ADediting_720738(17342448, +), ADediting_720739(17342457, +), ADediting_720740(17342458, +), ADediting_720741(17342465, +), ADediting_720742(17342468, +), ADediting_720743(17342503, +), ADediting_720744(17342507, +), ADediting_1553210(17342385, +), ADediting_1553211(17342477, +),

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RNA editing positional annotations for GTPBP3 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_720729	chr19_17342183_+	UTR3
ADediting_720730	chr19_17342203_+	UTR3
ADediting_720731	chr19_17342204_+	UTR3
ADediting_720732	chr19_17342291_+	UTR3
ADediting_720733	chr19_17342354_+	UTR3
ADediting_720734	chr19_17342367_+	UTR3
ADediting_720735	chr19_17342368_+	UTR3
ADediting_720736	chr19_17342397_+	UTR3
ADediting_720737	chr19_17342433_+	UTR3
ADediting_720738	chr19_17342448_+	UTR3
ADediting_720739	chr19_17342457_+	UTR3
ADediting_720740	chr19_17342458_+	UTR3
ADediting_720741	chr19_17342465_+	UTR3
ADediting_720742	chr19_17342468_+	UTR3
ADediting_720743	chr19_17342503_+	UTR3
ADediting_720744	chr19_17342507_+	UTR3
ADediting_1553210	chr19_17342385_+	UTR3
ADediting_1553211	chr19_17342477_+	UTR3

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_720729	chr19_17342183_+	SINE	Alu	Name=AluSx
ADediting_720730	chr19_17342203_+	SINE	Alu	Name=AluSx
ADediting_720731	chr19_17342204_+	SINE	Alu	Name=AluSx
ADediting_720732	chr19_17342291_+	SINE	Alu	Name=AluSx
ADediting_720733	chr19_17342354_+	SINE	Alu	Name=AluSx
ADediting_720734	chr19_17342367_+	SINE	Alu	Name=AluSx
ADediting_720735	chr19_17342368_+	SINE	Alu	Name=AluSx
ADediting_720736	chr19_17342397_+	SINE	Alu	Name=AluSx
ADediting_720737	chr19_17342433_+	SINE	Alu	Name=AluSx
ADediting_720738	chr19_17342448_+	SINE	Alu	Name=AluSx
ADediting_720739	chr19_17342457_+	SINE	Alu	Name=AluSx
ADediting_720740	chr19_17342458_+	SINE	Alu	Name=AluSx
ADediting_720741	chr19_17342465_+	SINE	Alu	Name=AluSx
ADediting_720742	chr19_17342468_+	SINE	Alu	Name=AluSx
ADediting_720743	chr19_17342503_+	SINE	Alu	Name=AluSx
ADediting_720744	chr19_17342507_+	SINE	Alu	Name=AluSx
ADediting_1553210	chr19_17342385_+	SINE	Alu	Name=AluSx
ADediting_1553211	chr19_17342477_+	SINE	Alu	Name=AluSx

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RNA A-to-I editing events in the alternative splicing sites for GTPBP3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GTPBP3

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for GTPBP3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GTPBP3

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6089	chr19	17342383	17342389	7mer-m8	17342367	17342390	164	-34.89
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6089	chr19	17342383	17342389	7mer-m8	17342367	17342390	164	-34.89
ADediting_1553211	chr19_17342477_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3940-3p	chr19	17342474	17342480	7mer-m8	17342460	17342481	142	-21.28
ADediting_1553211	chr19_17342477_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3940-3p	chr19	17342474	17342480	7mer-m8	17342460	17342481	142	-21.28
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-1199-5p	chr19	17342197	17342203	7mer-m8	17342185	17342204	152	-26.25
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6078	chr19	17342200	17342206	7mer-m8	17342189	17342207	151	-22.33
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6720-3p	chr19	17342201	17342207	7mer-m8	17342183	17342208	145	-23.81
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6751-3p	chr19	17342197	17342203	7mer-m8	17342184	17342204	146	-15.91
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-1199-5p	chr19	17342197	17342203	7mer-m8	17342185	17342204	152	-26.25
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6078	chr19	17342200	17342206	7mer-m8	17342189	17342207	151	-22.33
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6720-3p	chr19	17342201	17342207	7mer-m8	17342183	17342208	145	-23.81
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6751-3p	chr19	17342197	17342203	7mer-m8	17342184	17342204	146	-15.91
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-340-3p	chr19	17342285	17342292	8mer-1a	17342271	17342292	146	-18.22
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6827-3p	chr19	17342285	17342292	8mer-1a	17342272	17342292	140	-14.67
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-340-3p	chr19	17342285	17342292	8mer-1a	17342271	17342292	146	-18.22
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6827-3p	chr19	17342285	17342292	8mer-1a	17342272	17342292	140	-14.67
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-25-5p	chr19	17342349	17342355	7mer-m8	17342336	17342356	147	-19.01
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-658	chr19	17342348	17342354	7mer-m8	17342329	17342355	161	-37.11
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-25-5p	chr19	17342349	17342355	7mer-m8	17342336	17342356	147	-19.01
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-658	chr19	17342348	17342354	7mer-m8	17342329	17342355	161	-37.11
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3622a-3p	chr19	17342364	17342371	8mer-1a	17342350	17342371	148	-19.42
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3622b-3p	chr19	17342364	17342371	8mer-1a	17342351	17342371	153	-23.04
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3622a-3p	chr19	17342364	17342371	8mer-1a	17342350	17342371	148	-19.42
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3622b-3p	chr19	17342364	17342371	8mer-1a	17342351	17342371	153	-23.04
ADediting_720736	chr19_17342397_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-4691-3p	chr19	17342394	17342400	7mer-m8	17342380	17342401	146	-25.49
ADediting_720736	chr19_17342397_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-4691-3p	chr19	17342394	17342400	7mer-m8	17342380	17342401	146	-25.49
ADediting_720737	chr19_17342433_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-34a-3p	chr19	17342429	17342435	7mer-m8	17342415	17342436	140	-8.29
ADediting_720737	chr19_17342433_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-34a-3p	chr19	17342429	17342435	7mer-m8	17342415	17342436	140	-8.29
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3150a-5p	chr19	17342455	17342461	7mer-m8	17342443	17342462	153	-14.41
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3150b-5p	chr19	17342455	17342461	7mer-m8	17342441	17342462	140	-13.99
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3150a-5p	chr19	17342455	17342461	7mer-m8	17342443	17342462	153	-14.41
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3150b-5p	chr19	17342455	17342461	7mer-m8	17342441	17342462	140	-13.99
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-10a-5p	chr19	17342454	17342460	7mer-m8	17342439	17342461	145	-13.67
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-10b-5p	chr19	17342454	17342460	7mer-m8	17342439	17342461	140	-13.05
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-339-5p	chr19	17342453	17342459	7mer-m8	17342436	17342460	151	-18.58
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-4421	chr19	17342452	17342458	7mer-m8	17342438	17342459	154	-16.19
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-5699-3p	chr19	17342452	17342458	7mer-m8	17342438	17342459	153	-17.34
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6732-3p	chr19	17342455	17342461	7mer-m8	17342441	17342462	158	-19.01
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-10a-5p	chr19	17342454	17342460	7mer-m8	17342439	17342461	145	-13.67
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-10b-5p	chr19	17342454	17342460	7mer-m8	17342439	17342461	140	-13.05
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-339-5p	chr19	17342453	17342459	7mer-m8	17342436	17342460	151	-18.58
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-4421	chr19	17342452	17342458	7mer-m8	17342438	17342459	154	-16.19
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-5699-3p	chr19	17342452	17342458	7mer-m8	17342438	17342459	153	-17.34
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6732-3p	chr19	17342455	17342461	7mer-m8	17342441	17342462	158	-19.01
ADediting_720742	chr19_17342468_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-433-5p	chr19	17342462	17342468	7mer-m8	17342446	17342469	162	-26
ADediting_720742	chr19_17342468_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-433-5p	chr19	17342462	17342468	7mer-m8	17342446	17342469	162	-26
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-1288-5p	chr19	17342505	17342511	7mer-m8	17342493	17342512	144	-17.2
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3622a-3p	chr19	17342500	17342507	8mer-1a	17342486	17342507	144	-13.55
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3622b-3p	chr19	17342500	17342507	8mer-1a	17342487	17342507	152	-18.35
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-1288-5p	chr19	17342505	17342511	7mer-m8	17342493	17342512	144	-17.2
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3622a-3p	chr19	17342500	17342507	8mer-1a	17342486	17342507	144	-13.55
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3622b-3p	chr19	17342500	17342507	8mer-1a	17342487	17342507	152	-18.35

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-4478	chr19	17342382	17342388	7mer-m8	17342374	17342389	149	-25.05
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-4649-3p	chr19	17342379	17342385	7mer-m8	17342366	17342386	140	-14.11
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-7160-5p	chr19	17342380	17342386	7mer-m8	17342367	17342387	146	-17.63
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-4478	chr19	17342382	17342388	7mer-m8	17342374	17342389	149	-25.05
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-4649-3p	chr19	17342379	17342385	7mer-m8	17342366	17342386	140	-14.11
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-7160-5p	chr19	17342380	17342386	7mer-m8	17342367	17342387	146	-17.63
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-377-5p	chr19	17342181	17342187	7mer-m8	17342167	17342188	155	-17.58
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6086	chr19	17342181	17342187	7mer-m8	17342169	17342188	148	-21.93
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6516-5p	chr19	17342177	17342183	7mer-m8	17342162	17342184	146	-16.65
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-377-5p	chr19	17342181	17342187	7mer-m8	17342167	17342188	155	-17.58
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6086	chr19	17342181	17342187	7mer-m8	17342169	17342188	148	-21.93
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6516-5p	chr19	17342177	17342183	7mer-m8	17342162	17342184	146	-16.65
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-4522	chr19	17342289	17342295	7mer-m8	17342276	17342296	148	-13.37
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6888-3p	chr19	17342286	17342292	7mer-m8	17342273	17342293	151	-14.42
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-4522	chr19	17342289	17342295	7mer-m8	17342276	17342296	148	-13.37
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6888-3p	chr19	17342286	17342292	7mer-m8	17342273	17342293	151	-14.42
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3689d	chr19	17342352	17342358	7mer-m8	17342339	17342359	146	-17.7
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6851-5p	chr19	17342352	17342358	7mer-m8	17342337	17342359	146	-24.28
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-7847-3p	chr19	17342348	17342354	7mer-m8	17342334	17342355	148	-18.26
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3689d	chr19	17342352	17342358	7mer-m8	17342339	17342359	146	-17.7
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6851-5p	chr19	17342352	17342358	7mer-m8	17342337	17342359	146	-24.28
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-7847-3p	chr19	17342348	17342354	7mer-m8	17342334	17342355	148	-18.26
ADediting_720734	chr19_17342367_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3614-5p	chr19	17342365	17342371	7mer-1a	17342349	17342371	148	-22.44
ADediting_720734	chr19_17342367_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3614-5p	chr19	17342365	17342371	7mer-1a	17342349	17342371	148	-22.44
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-3614-5p	chr19	17342365	17342371	7mer-1a	17342349	17342371	148	-22.44
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-3614-5p	chr19	17342365	17342371	7mer-1a	17342349	17342371	148	-22.44
ADediting_720736	chr19_17342397_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-5690	chr19	17342394	17342400	7mer-m8	17342381	17342401	145	-16.75
ADediting_720736	chr19_17342397_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-5690	chr19	17342394	17342400	7mer-m8	17342381	17342401	145	-16.75
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-6818-3p	chr19	17342450	17342457	8mer-1a	17342436	17342457	140	-12.42
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-6818-3p	chr19	17342450	17342457	8mer-1a	17342436	17342457	140	-12.42
ADediting_720743	chr19_17342503_+	ENSG00000130299.17	ENST00000324894.13	GTPBP3-201	hsa-miR-7162-3p	chr19	17342497	17342503	7mer-m8	17342486	17342504	147	-16.77
ADediting_720743	chr19_17342503_+	ENSG00000130299.17	ENST00000600625.5	GTPBP3-222	hsa-miR-7162-3p	chr19	17342497	17342503	7mer-m8	17342486	17342504	147	-16.77

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6089	chr19	17342384	17342390	7mer-m8	17342368	17342391	164	-34.89
ADediting_1553211	chr19_17342477_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3940-3p	chr19	17342475	17342481	7mer-m8	17342461	17342482	142	-21.28
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-1199-5p	chr19	17342198	17342204	7mer-m8	17342186	17342205	152	-26.25
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6078	chr19	17342201	17342207	7mer-m8	17342190	17342208	151	-22.33
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6720-3p	chr19	17342202	17342208	7mer-m8	17342184	17342209	145	-23.81
ADediting_720731	chr19_17342204_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6751-3p	chr19	17342198	17342204	7mer-m8	17342185	17342205	146	-15.91
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-340-3p	chr19	17342286	17342293	8mer-1a	17342272	17342293	146	-18.22
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6827-3p	chr19	17342286	17342293	8mer-1a	17342273	17342293	140	-14.67
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-25-5p	chr19	17342350	17342356	7mer-m8	17342337	17342357	147	-19.01
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-658	chr19	17342349	17342355	7mer-m8	17342330	17342356	161	-37.11
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3622a-3p	chr19	17342365	17342372	8mer-1a	17342351	17342372	148	-19.42
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3622b-3p	chr19	17342365	17342372	8mer-1a	17342352	17342372	153	-23.04
ADediting_720736	chr19_17342397_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-4691-3p	chr19	17342395	17342401	7mer-m8	17342381	17342402	146	-25.49
ADediting_720737	chr19_17342433_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-34a-3p	chr19	17342430	17342436	7mer-m8	17342416	17342437	140	-8.29
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3150a-5p	chr19	17342456	17342462	7mer-m8	17342444	17342463	153	-14.41
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3150b-5p	chr19	17342456	17342462	7mer-m8	17342442	17342463	140	-13.99
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-10a-5p	chr19	17342455	17342461	7mer-m8	17342440	17342462	145	-13.67
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-10b-5p	chr19	17342455	17342461	7mer-m8	17342440	17342462	140	-13.05
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-339-5p	chr19	17342454	17342460	7mer-m8	17342437	17342461	151	-18.58
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-4421	chr19	17342453	17342459	7mer-m8	17342439	17342460	154	-16.19
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-5699-3p	chr19	17342453	17342459	7mer-m8	17342439	17342460	153	-17.34
ADediting_720740	chr19_17342458_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6732-3p	chr19	17342456	17342462	7mer-m8	17342442	17342463	158	-19.01
ADediting_720742	chr19_17342468_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-433-5p	chr19	17342463	17342469	7mer-m8	17342447	17342470	162	-26
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-1288-5p	chr19	17342506	17342512	7mer-m8	17342494	17342513	144	-17.2
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3622a-3p	chr19	17342501	17342508	8mer-1a	17342487	17342508	144	-13.55
ADediting_720744	chr19_17342507_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3622b-3p	chr19	17342501	17342508	8mer-1a	17342488	17342508	152	-18.35

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-4478	chr19	17342383	17342389	7mer-m8	17342375	17342390	149	-25.05
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-4649-3p	chr19	17342380	17342386	7mer-m8	17342367	17342387	140	-14.11
ADediting_1553210	chr19_17342385_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-7160-5p	chr19	17342381	17342387	7mer-m8	17342368	17342388	146	-17.63
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-377-5p	chr19	17342182	17342188	7mer-m8	17342168	17342189	155	-17.58
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6086	chr19	17342182	17342188	7mer-m8	17342170	17342189	148	-21.93
ADediting_720729	chr19_17342183_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6516-5p	chr19	17342178	17342184	7mer-m8	17342163	17342185	146	-16.65
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-4522	chr19	17342290	17342296	7mer-m8	17342277	17342297	148	-13.37
ADediting_720732	chr19_17342291_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6888-3p	chr19	17342287	17342293	7mer-m8	17342274	17342294	151	-14.42
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3689d	chr19	17342353	17342359	7mer-m8	17342340	17342360	146	-17.7
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6851-5p	chr19	17342353	17342359	7mer-m8	17342338	17342360	146	-24.28
ADediting_720733	chr19_17342354_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-7847-3p	chr19	17342349	17342355	7mer-m8	17342335	17342356	148	-18.26
ADediting_720734	chr19_17342367_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3614-5p	chr19	17342366	17342372	7mer-1a	17342350	17342372	148	-22.44
ADediting_720735	chr19_17342368_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-3614-5p	chr19	17342366	17342372	7mer-1a	17342350	17342372	148	-22.44
ADediting_720736	chr19_17342397_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-5690	chr19	17342395	17342401	7mer-m8	17342382	17342402	145	-16.75
ADediting_720739	chr19_17342457_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-6818-3p	chr19	17342451	17342458	8mer-1a	17342437	17342458	140	-12.42
ADediting_720743	chr19_17342503_+	ENSG00000130299.17	ENST00000598038.5	GTPBP3-216	hsa-miR-7162-3p	chr19	17342498	17342504	7mer-m8	17342487	17342505	147	-16.77

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1097295

chr3_85385762_+

ENSG00000130299.17

ENST00000324894.13

GTPBP3-201

hsa-miR-5688

chr19

17342684

17342690

7mer-m8

17342670

17342691

158

-12.03

ADediting_1097295

chr3_85385762_+

ENSG00000130299.17

ENST00000600625.5

GTPBP3-222

hsa-miR-5688

chr19

17342684

17342690

7mer-m8

17342670

17342691

158

-12.03

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_496066

chr15_66496985_-

ENSG00000130299.17

ENST00000324894.13

GTPBP3-201

hsa-miR-4512

chr19

17341878

17341884

7mer-m8

17341864

17341885

146

-20.27

ADediting_496066

chr15_66496985_-

ENSG00000130299.17

ENST00000358792.11

GTPBP3-202

hsa-miR-4512

chr19

17341878

17341884

7mer-m8

17341864

17341885

146

-20.27

ADediting_496066

chr15_66496985_-

ENSG00000130299.17

ENST00000361619.9

GTPBP3-203

hsa-miR-4512

chr19

17341878

17341884

7mer-m8

17341864

17341885

146

-20.27

ADediting_496066

chr15_66496985_-

ENSG00000130299.17

ENST00000600625.5

GTPBP3-222

hsa-miR-4512

chr19

17341878

17341884

7mer-m8

17341864

17341885

146

-20.27

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for GTPBP3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000598038.5	lncRNA
ENST00000324894.13	protein_coding
ENST00000600625.5	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_720729	ENST00000324894.13	chr19_17342183_+	2018	-1121.30	-1121.30	-1140.40
ADediting_720730	ENST00000324894.13	chr19_17342203_+	2038	-1121.50	-1121.30	-1140.40
ADediting_720731	ENST00000324894.13	chr19_17342204_+	2039	-1121.90	-1121.30	-1140.40
ADediting_720732	ENST00000324894.13	chr19_17342291_+	2126	-1120.60	-1121.30	-1140.40
ADediting_720733	ENST00000324894.13	chr19_17342354_+	2189	-1122.30	-1121.30	-1140.40
ADediting_720734	ENST00000324894.13	chr19_17342367_+	2202	-1121.30	-1121.30	-1140.40
ADediting_720735	ENST00000324894.13	chr19_17342368_+	2203	-1125.20	-1121.30	-1140.40
ADediting_1553210	ENST00000324894.13	chr19_17342385_+	2220	-1120.90	-1121.30	-1140.40
ADediting_720736	ENST00000324894.13	chr19_17342397_+	2232	-1125.60	-1121.30	-1140.40
ADediting_720737	ENST00000324894.13	chr19_17342433_+	2268	-1123.00	-1121.30	-1140.40
ADediting_720738	ENST00000324894.13	chr19_17342448_+	2283	-1121.20	-1121.30	-1140.40
ADediting_720739	ENST00000324894.13	chr19_17342457_+	2292	-1121.20	-1121.30	-1140.40
ADediting_720740	ENST00000324894.13	chr19_17342458_+	2293	-1121.00	-1121.30	-1140.40
ADediting_720741	ENST00000324894.13	chr19_17342465_+	2300	-1121.60	-1121.30	-1140.40
ADediting_720742	ENST00000324894.13	chr19_17342468_+	2303	-1121.10	-1121.30	-1140.40
ADediting_1553211	ENST00000324894.13	chr19_17342477_+	2312	-1121.50	-1121.30	-1140.40
ADediting_720743	ENST00000324894.13	chr19_17342503_+	2338	-1121.20	-1121.30	-1140.40
ADediting_720744	ENST00000324894.13	chr19_17342507_+	2342	-1121.00	-1121.30	-1140.40
ADediting_720729	ENST00000600625.5	chr19_17342183_+	1953	-1088.60	-1086.20	-1107.00
ADediting_720730	ENST00000600625.5	chr19_17342203_+	1973	-1086.20	-1086.20	-1107.00
ADediting_720731	ENST00000600625.5	chr19_17342204_+	1974	-1086.20	-1086.20	-1107.00
ADediting_720732	ENST00000600625.5	chr19_17342291_+	2061	-1085.50	-1086.20	-1107.00
ADediting_720733	ENST00000600625.5	chr19_17342354_+	2124	-1087.20	-1086.20	-1107.00
ADediting_720734	ENST00000600625.5	chr19_17342367_+	2137	-1086.20	-1086.20	-1107.00
ADediting_720735	ENST00000600625.5	chr19_17342368_+	2138	-1089.10	-1086.20	-1107.00
ADediting_1553210	ENST00000600625.5	chr19_17342385_+	2155	-1086.40	-1086.20	-1107.00
ADediting_720736	ENST00000600625.5	chr19_17342397_+	2167	-1090.50	-1086.20	-1107.00
ADediting_720737	ENST00000600625.5	chr19_17342433_+	2203	-1087.90	-1086.20	-1107.00
ADediting_720738	ENST00000600625.5	chr19_17342448_+	2218	-1086.10	-1086.20	-1107.00
ADediting_720739	ENST00000600625.5	chr19_17342457_+	2227	-1086.10	-1086.20	-1107.00
ADediting_720740	ENST00000600625.5	chr19_17342458_+	2228	-1085.90	-1086.20	-1107.00
ADediting_720741	ENST00000600625.5	chr19_17342465_+	2235	-1086.50	-1086.20	-1107.00
ADediting_720742	ENST00000600625.5	chr19_17342468_+	2238	-1086.00	-1086.20	-1107.00
ADediting_1553211	ENST00000600625.5	chr19_17342477_+	2247	-1086.40	-1086.20	-1107.00
ADediting_720743	ENST00000600625.5	chr19_17342503_+	2273	-1086.10	-1086.20	-1107.00
ADediting_720744	ENST00000600625.5	chr19_17342507_+	2277	-1089.30	-1086.20	-1107.00

RNA A-to-I editing in lncRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_720729	ENST00000598038.5	chr19_17342183_+	2370	-1243.50	-1243.80	-1263.80
ADediting_720730	ENST00000598038.5	chr19_17342203_+	2390	-1246.10	-1243.80	-1263.80
ADediting_720731	ENST00000598038.5	chr19_17342204_+	2391	-1246.00	-1243.80	-1263.80
ADediting_720732	ENST00000598038.5	chr19_17342291_+	2478	-1245.20	-1243.80	-1263.80
ADediting_720733	ENST00000598038.5	chr19_17342354_+	2541	-1244.80	-1243.80	-1263.80
ADediting_720734	ENST00000598038.5	chr19_17342367_+	2554	-1245.10	-1243.80	-1263.80
ADediting_720735	ENST00000598038.5	chr19_17342368_+	2555	-1248.20	-1243.80	-1263.80
ADediting_1553210	ENST00000598038.5	chr19_17342385_+	2572	-1243.30	-1243.80	-1263.80
ADediting_720736	ENST00000598038.5	chr19_17342397_+	2584	-1247.40	-1243.80	-1263.80
ADediting_720737	ENST00000598038.5	chr19_17342433_+	2620	-1246.00	-1243.80	-1263.80
ADediting_720738	ENST00000598038.5	chr19_17342448_+	2635	-1246.30	-1243.80	-1263.80
ADediting_720739	ENST00000598038.5	chr19_17342457_+	2644	-1246.80	-1243.80	-1263.80
ADediting_720740	ENST00000598038.5	chr19_17342458_+	2645	-1244.50	-1243.80	-1263.80
ADediting_720741	ENST00000598038.5	chr19_17342465_+	2652	-1244.70	-1243.80	-1263.80
ADediting_720742	ENST00000598038.5	chr19_17342468_+	2655	-1245.20	-1243.80	-1263.80
ADediting_1553211	ENST00000598038.5	chr19_17342477_+	2664	-1246.80	-1243.80	-1263.80
ADediting_720743	ENST00000598038.5	chr19_17342503_+	2690	-1245.10	-1243.80	-1263.80
ADediting_720744	ENST00000598038.5	chr19_17342507_+	2694	-1247.30	-1243.80	-1263.80

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Relation with ADAR for GTPBP3

Correlation between ADAR gene expression and RNA editing frequency

Tissue

ADeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	4.69978387118928e-20	0.489163237186087	2.38951309779795e-13	0.400137191006967	5.70178654888066e-46	0.694623627213155
AC	2.23861021283033e-35	0.680705854544832	1.02315416024931e-28	0.626985508910787	2.59311982334565e-14	0.457132247231125
PCC	2.70812600297623e-29	0.698657990056227	8.00347340103533e-30	0.703312572584686	3.72490179813097e-06	0.327604355963748
CER	4.75387753910647e-06	0.363742011758629	1.8519794567942e-05	0.341891349926429	0.0488980119927295	0.16110305548504
TCX	4.16189746062499e-14	0.566494488292456	1.04445867758426e-05	0.351292573392651	4.33564082977054e-06	0.365165036285333
FP	7.23799386894052e-14	0.52266661645025	1.32979483450422e-11	0.479114119656484	7.87413590859921e-09	0.415751288615944
IFG	7.07824412977873e-05	0.709759858784691	0.000106431857621194	0.697504984268571	0.0314221131064182	0.431128909678056
STG	7.4797900605823e-10	0.609706821614303	3.85485246053674e-05	0.433206308420196	4.03184811322424e-06	0.479042770538766

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Relation with AD stages for GTPBP3

Correlation between AD stages and RNA editing frequency

Tissue

ADeditomID

position

P-val

Coeff.

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
TCX	0.000836071740509109	0.319696269923384

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RelatedDrugs for GTPBP3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GTPBP3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GTPBP3	C4015447	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 23	2	CTD_human;ORPHANET;UNIPROT
GTPBP3	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND

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Gene summary for GTPBP3

RNA A-to-I events for GTPBP3

RNA editing positional annotations for GTPBP3 using Annovar

RNA A-to-I editing events in the alternative splicing sites for GTPBP3

Differntial gene expression between RNA A-to-I edited versus non-edited samples for GTPBP3

Protein coding region RNA A-to-I editings for GTPBP3

The effects of the RNA editing to the miRNA binding sites for GTPBP3

The effects of the RNA editing to the stability of the RNA structures for GTPBP3

Relation with ADAR for GTPBP3

Relation with AD stages for GTPBP3

RelatedDrugs for GTPBP3

RelatedDiseases for GTPBP3

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene