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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for LZTS2

check button Gene summary
Gene informationGene symbol

LZTS2

Gene ID

84445

Gene nameleucine zipper tumor suppressor 2
SynonymsLAPSER1
Cytomap

10q24.31

Type of geneprotein-coding
Descriptionleucine zipper putative tumor suppressor 2leucine zipper, putative tumor suppressor 2protein LAPSER1
Modification date20200327
UniProtAcc

Q9BRK4,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for LZTS2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_155112(101004352, +), ADediting_155113(101004374, +), ADediting_155114(101004400, +), ADediting_155115(101004408, +), ADediting_155116(101004411, +), ADediting_155117(101004412, +), ADediting_155118(101004448, +), ADediting_155119(101004456, +), ADediting_155120(101004460, +), ADediting_155121(101004461, +), ADediting_155122(101004482, +), ADediting_155123(101004488, +), ADediting_155124(101004492, +), ADediting_155125(101004505, +), ADediting_155126(101004518, +), ADediting_155127(101004523, +), ADediting_155128(101004528, +), ADediting_155129(101004545, +), ADediting_155130(101004560, +), ADediting_155131(101004573, +), ADediting_155132(101004590, +), ADediting_155133(101004598, +), ADediting_155134(101004908, +), ADediting_155135(101004959, +), ADediting_155136(101004960, +), ADediting_155137(101005023, +), ADediting_155138(101005027, +), ADediting_155139(101005028, +), ADediting_155140(101005035, +), ADediting_155141(101005043, +), ADediting_155142(101005052, +), ADediting_155143(101005059, +), ADediting_155144(101005073, +), ADediting_155145(101005083, +), ADediting_155146(101005089, +), ADediting_155147(101005103, +), ADediting_155148(101005104, +), ADediting_155149(101005107, +), ADediting_155150(101005121, +), ADediting_155151(101005129, +), ADediting_155152(101005130, +), ADediting_155153(101005133, +), ADediting_155154(101005138, +), ADediting_155155(101005143, +), ADediting_155156(101005145, +), ADediting_155157(101005245, +), ADediting_1522077(101004972, +), ADediting_1522078(101005237, +), ADediting_1603402(101004351, +),

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RNA editing positional annotations for LZTS2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_155112chr10_101004352_+intronic
ADediting_155113chr10_101004374_+intronic
ADediting_155114chr10_101004400_+intronic
ADediting_155115chr10_101004408_+intronic
ADediting_155116chr10_101004411_+intronic
ADediting_155117chr10_101004412_+intronic
ADediting_155118chr10_101004448_+intronic
ADediting_155119chr10_101004456_+intronic
ADediting_155120chr10_101004460_+intronic
ADediting_155121chr10_101004461_+intronic
ADediting_155122chr10_101004482_+intronic
ADediting_155123chr10_101004488_+intronic
ADediting_155124chr10_101004492_+intronic
ADediting_155125chr10_101004505_+intronic
ADediting_155126chr10_101004518_+intronic
ADediting_155127chr10_101004523_+intronic
ADediting_155128chr10_101004528_+intronic
ADediting_155129chr10_101004545_+intronic
ADediting_155130chr10_101004560_+intronic
ADediting_155131chr10_101004573_+intronic
ADediting_155132chr10_101004590_+intronic
ADediting_155133chr10_101004598_+intronic
ADediting_155134chr10_101004908_+intronic
ADediting_155135chr10_101004959_+intronic
ADediting_155136chr10_101004960_+intronic
ADediting_155137chr10_101005023_+intronic
ADediting_155138chr10_101005027_+intronic
ADediting_155139chr10_101005028_+intronic
ADediting_155140chr10_101005035_+intronic
ADediting_155141chr10_101005043_+intronic
ADediting_155142chr10_101005052_+intronic
ADediting_155143chr10_101005059_+intronic
ADediting_155144chr10_101005073_+intronic
ADediting_155145chr10_101005083_+intronic
ADediting_155146chr10_101005089_+intronic
ADediting_155147chr10_101005103_+intronic
ADediting_155148chr10_101005104_+intronic
ADediting_155149chr10_101005107_+intronic
ADediting_155150chr10_101005121_+intronic
ADediting_155151chr10_101005129_+intronic
ADediting_155152chr10_101005130_+intronic
ADediting_155153chr10_101005133_+intronic
ADediting_155154chr10_101005138_+intronic
ADediting_155155chr10_101005143_+intronic
ADediting_155156chr10_101005145_+intronic
ADediting_155157chr10_101005245_+intronic
ADediting_1522077chr10_101004972_+intronic
ADediting_1522078chr10_101005237_+intronic
ADediting_1603402chr10_101004351_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_155112chr10_101004352_+SINEAluName=AluSz
ADediting_155113chr10_101004374_+SINEAluName=AluSz
ADediting_155114chr10_101004400_+SINEAluName=AluSz
ADediting_155115chr10_101004408_+SINEAluName=AluSz
ADediting_155116chr10_101004411_+SINEAluName=AluSz
ADediting_155117chr10_101004412_+SINEAluName=AluSz
ADediting_155118chr10_101004448_+SINEAluName=AluSz
ADediting_155119chr10_101004456_+SINEAluName=AluSz
ADediting_155120chr10_101004460_+SINEAluName=AluSz
ADediting_155121chr10_101004461_+SINEAluName=AluSz
ADediting_155122chr10_101004482_+SINEAluName=AluSz
ADediting_155123chr10_101004488_+SINEAluName=AluSz
ADediting_155124chr10_101004492_+SINEAluName=AluSz
ADediting_155125chr10_101004505_+SINEAluName=AluSz
ADediting_155126chr10_101004518_+SINEAluName=AluSz
ADediting_155127chr10_101004523_+SINEAluName=AluSz
ADediting_155128chr10_101004528_+SINEAluName=AluSz
ADediting_155129chr10_101004545_+SINEAluName=AluSz
ADediting_155130chr10_101004560_+SINEAluName=AluSz
ADediting_155131chr10_101004573_+SINEAluName=AluSz
ADediting_155132chr10_101004590_+SINEAluName=AluSz
ADediting_155133chr10_101004598_+SINEAluName=AluSz
ADediting_155134chr10_101004908_+SINEAluName=AluSz
ADediting_155135chr10_101004959_+SINEAluName=AluSz
ADediting_155136chr10_101004960_+SINEAluName=AluSz
ADediting_155137chr10_101005023_+SINEAluName=AluJb
ADediting_155138chr10_101005027_+SINEAluName=AluJb
ADediting_155139chr10_101005028_+SINEAluName=AluJb
ADediting_155140chr10_101005035_+SINEAluName=AluJb
ADediting_155141chr10_101005043_+SINEAluName=AluJb
ADediting_155142chr10_101005052_+SINEAluName=AluJb
ADediting_155143chr10_101005059_+SINEAluName=AluJb
ADediting_155144chr10_101005073_+SINEAluName=AluJb
ADediting_155145chr10_101005083_+SINEAluName=AluJb
ADediting_155146chr10_101005089_+SINEAluName=AluJb
ADediting_155147chr10_101005103_+SINEAluName=AluJb
ADediting_155148chr10_101005104_+SINEAluName=AluJb
ADediting_155149chr10_101005107_+SINEAluName=AluJb
ADediting_155150chr10_101005121_+SINEAluName=AluJb
ADediting_155151chr10_101005129_+SINEAluName=AluJb
ADediting_155152chr10_101005130_+SINEAluName=AluJb
ADediting_155153chr10_101005133_+SINEAluName=AluJb
ADediting_155154chr10_101005138_+SINEAluName=AluJb
ADediting_155155chr10_101005143_+SINEAluName=AluJb
ADediting_155156chr10_101005145_+SINEAluName=AluJb
ADediting_155157chr10_101005245_+SINEAluName=AluJb
ADediting_1522077chr10_101004972_+SINEAluName=AluSz
ADediting_1522078chr10_101005237_+SINEAluName=AluJb
ADediting_1603402chr10_101004351_+SINEAluName=AluSz

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RNA A-to-I editing events in the alternative splicing sites for LZTS2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LZTS2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for LZTS2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for LZTS2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000107816.17ENST00000370220.1LZTS2-201hsa-miR-589-5pchr101010076121010076198mer-1a101007597101007619151-24.7
ADediting_1337758chr7_5495892_-ENSG00000107816.17ENST00000370223.7LZTS2-202hsa-miR-589-5pchr101010076121010076198mer-1a101007597101007619151-24.7

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1535953chr14_101045971_+ENSG00000107816.17ENST00000370220.1LZTS2-201hsa-miR-381-3pchr101010077571010077648mer-1a101007743101007764155-11.16
ADediting_1535953chr14_101045971_+ENSG00000107816.17ENST00000370223.7LZTS2-202hsa-miR-381-3pchr101010077571010077648mer-1a101007743101007764155-11.16
ADediting_1535954chr14_101045974_+ENSG00000107816.17ENST00000370220.1LZTS2-201hsa-miR-381-3pchr101010077571010077648mer-1a101007743101007764155-11.16
ADediting_1535954chr14_101045974_+ENSG00000107816.17ENST00000370223.7LZTS2-202hsa-miR-381-3pchr101010077571010077648mer-1a101007743101007764155-11.16
ADediting_1556067chr19_40282625_-ENSG00000107816.17ENST00000370220.1LZTS2-201hsa-miR-641chr101010076881010076947mer-m8101007672101007695140-12.84
ADediting_1556067chr19_40282625_-ENSG00000107816.17ENST00000370223.7LZTS2-202hsa-miR-641chr101010076881010076947mer-m8101007672101007695140-12.84
ADediting_1631458chr19_40282624_-ENSG00000107816.17ENST00000370220.1LZTS2-201hsa-miR-641chr101010076881010076947mer-m8101007672101007695140-12.84
ADediting_1631458chr19_40282624_-ENSG00000107816.17ENST00000370223.7LZTS2-202hsa-miR-641chr101010076881010076947mer-m8101007672101007695140-12.84

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LZTS2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for LZTS2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_155117chr10_101004412_+0.001416307914666830.2582936324123236.29225077768569e-060.3593674610686010.486884950502612-0.0572007152424852
ACADediting_155122chr10_101004482_+0.006414889295433110.1719693982828590.01484184357166780.1539317987328961.42379860152056e-070.325340000676032
DLPFCADediting_155123chr10_101004488_+2.65800744685322e-050.2361681363159084.68763861218409e-090.3249468989905930.0006737504073940920.192084187333787
ACADediting_155123chr10_101004488_+0.000525143849847170.2177633540089660.006200843107354370.1726643321058863.60685058864934e-090.362289395515743
CERADediting_155123chr10_101004488_+2.58888104240666e-060.3730101056858241.11342715058268e-090.4716485027373020.5722748966999010.046471750184076
CERADediting_155128chr10_101004528_+0.005799960626298950.2242611673345823.38156443034041e-060.3689719017097740.4439326218248490.0629731950447289
CERADediting_155130chr10_101004560_+1.71101573890705e-050.3432089258490531.25961437434709e-050.3482511482542160.137227884573430.121913958986697
TCXADediting_155130chr10_101004560_+0.2938230331638630.08627530787271612.33688228684615e-060.3745440063651520.087702810034973-0.139912145213273
DLPFCADediting_155133chr10_101004598_+8.37930287812002e-090.3198405442222224.49364730989243e-100.3446539456951790.1441152274280480.0831507630648647
TCXADediting_155141chr10_101005043_+0.14546735094860.1194330718995277.57659673594172e-050.3173817436134520.0143885684893106-0.199486502859042
TCXADediting_155142chr10_101005052_+0.1489678402445870.118411296517649.79030662572648e-050.3126871768228810.0199723794543155-0.189844821667824
TCXADediting_155152chr10_101005130_+0.01136523344203150.2061760817413676.3607727847979e-050.3205411597319460.0856289780166313-0.140826977879702
DLPFCADediting_155155chr10_101005143_+0.0001175646087411770.2169953832818152.77444091632156e-080.3090024123865530.01480639938349010.138309710536507

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC5.23419105120887e-130.3948326035334445.43583977278088e-130.394574465237874.1649003443665e-400.659750089058067
AC8.31515664305627e-400.7110333614255575.16907417270743e-280.6206291870226831.23990385032682e-360.6896976456014
PCC1.70867849819378e-120.4818000958822245.80135814689322e-130.4906310138667791.26614965806756e-100.44385139125178
CER0.0004492884113154630.2830194567515859.51264475965175e-070.3876814919587120.006209377298845780.222489052424561
TCX0.005282533329829490.2266679339658770.0155585214326076-0.1972252943818423.77941598459742e-260.72909903643358
FP1.98000564735803e-070.3779514835599140.001416994977340620.2374310707965721.1672678982792e-260.69161156778694
IFG0.001640391181697450.596707655376530.008121134982411320.5171015846398780.0002201039727361960.674101687790174
PG0.0382792541968142-0.1520561022194962.13490895174963e-05-0.3061924105136922.62292560695316e-200.609577008852309
STG0.0001960373833170310.3955523954691780.5660820469806840.06349832854201972.68170057401932e-110.648008450397058

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Relation with AD stages for LZTS2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX9.83494066775e-060.414793370048554

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RelatedDrugs for LZTS2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LZTS2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
LZTS2C1527249Colorectal Cancer1UNIPROT