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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for NUDT22 |
 Gene summary |
| Gene information | Gene symbol | NUDT22 | Gene ID | 84304 |
| Gene name | nudix hydrolase 22 | |
| Synonyms | - | |
| Cytomap | 11q13.1 | |
| Type of gene | protein-coding | |
| Description | uridine diphosphate glucose pyrophosphatase NUDT22UDPG pyrophosphataseUGPPasenucleoside diphosphate-linked moiety X motif 22nudix (nucleoside diphosphate linked moiety X)-type motif 22nudix motif 22uridine diphosphate glucose pyrophosphatase | |
| Modification date | 20200313 | |
| UniProtAcc | Q9BRQ3, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for NUDT22 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_265914(64227484, +), ADediting_265915(64227826, +), ADediting_265916(64227889, +), ADediting_265917(64227893, +), ADediting_265918(64227921, +), ADediting_265919(64227944, +), ADediting_265920(64227956, +), ADediting_265921(64227982, +), ADediting_265922(64228009, +), ADediting_265923(64228053, +), ADediting_265924(64228056, +), ADediting_265925(64228070, +), ADediting_265926(64228078, +), ADediting_265927(64228123, +), ADediting_265928(64228131, +), ADediting_265929(64228132, +), ADediting_265930(64228133, +), ADediting_265931(64228145, +), ADediting_265932(64228208, +), ADediting_265933(64228283, +), ADediting_265934(64228410, +), ADediting_265935(64228432, +), ADediting_265936(64228447, +), ADediting_265937(64228462, +), ADediting_265938(64228476, +), ADediting_265939(64228477, +), ADediting_265940(64228487, +), ADediting_265941(64228501, +), ADediting_265942(64228502, +), ADediting_265943(64228507, +), ADediting_265944(64228517, +), ADediting_265945(64228543, +), ADediting_265946(64228570, +), ADediting_265947(64228647, +), ADediting_265948(64228709, +), ADediting_265949(64228761, +), ADediting_265950(64228784, +), ADediting_265951(64228785, +), ADediting_265952(64228809, +), ADediting_265953(64228810, +), ADediting_265954(64228812, +), ADediting_265955(64228813, +), ADediting_265956(64228815, +), ADediting_265957(64228825, +), ADediting_265958(64228851, +), ADediting_265959(64228852, +), ADediting_265960(64228857, +), ADediting_265961(64228878, +), ADediting_265962(64228904, +), ADediting_265963(64228913, +), ADediting_265964(64228917, +), ADediting_265965(64228924, +), ADediting_265966(64228942, +), ADediting_265967(64228967, +), ADediting_265968(64228977, +), ADediting_265969(64228991, +), ADediting_1527618(64228233, +), ADediting_1527619(64228263, +), ADediting_1527620(64228922, +), |
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RNA editing positional annotations for NUDT22 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_265914 | chr11_64227484_+ | synonymous SNV | ENST00000428347.2 | c.A564G | p.Q188Q | . | . | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_265914 | chr11_64227484_+ | exonic |
| ADediting_265915 | chr11_64227826_+ | intronic |
| ADediting_265916 | chr11_64227889_+ | intronic |
| ADediting_265917 | chr11_64227893_+ | intronic |
| ADediting_265918 | chr11_64227921_+ | intronic |
| ADediting_265919 | chr11_64227944_+ | intronic |
| ADediting_265920 | chr11_64227956_+ | intronic |
| ADediting_265921 | chr11_64227982_+ | intronic |
| ADediting_265922 | chr11_64228009_+ | intronic |
| ADediting_265923 | chr11_64228053_+ | intronic |
| ADediting_265924 | chr11_64228056_+ | intronic |
| ADediting_265925 | chr11_64228070_+ | intronic |
| ADediting_265926 | chr11_64228078_+ | intronic |
| ADediting_265927 | chr11_64228123_+ | intronic |
| ADediting_265928 | chr11_64228131_+ | intronic |
| ADediting_265929 | chr11_64228132_+ | intronic |
| ADediting_265930 | chr11_64228133_+ | intronic |
| ADediting_265931 | chr11_64228145_+ | intronic |
| ADediting_265932 | chr11_64228208_+ | intronic |
| ADediting_265933 | chr11_64228283_+ | intronic |
| ADediting_265934 | chr11_64228410_+ | intronic |
| ADediting_265935 | chr11_64228432_+ | intronic |
| ADediting_265936 | chr11_64228447_+ | intronic |
| ADediting_265937 | chr11_64228462_+ | intronic |
| ADediting_265938 | chr11_64228476_+ | intronic |
| ADediting_265939 | chr11_64228477_+ | intronic |
| ADediting_265940 | chr11_64228487_+ | intronic |
| ADediting_265941 | chr11_64228501_+ | intronic |
| ADediting_265942 | chr11_64228502_+ | intronic |
| ADediting_265943 | chr11_64228507_+ | intronic |
| ADediting_265944 | chr11_64228517_+ | intronic |
| ADediting_265945 | chr11_64228543_+ | intronic |
| ADediting_265946 | chr11_64228570_+ | intronic |
| ADediting_265947 | chr11_64228647_+ | intronic |
| ADediting_265948 | chr11_64228709_+ | intronic |
| ADediting_265949 | chr11_64228761_+ | intronic |
| ADediting_265950 | chr11_64228784_+ | intronic |
| ADediting_265951 | chr11_64228785_+ | intronic |
| ADediting_265952 | chr11_64228809_+ | intronic |
| ADediting_265953 | chr11_64228810_+ | intronic |
| ADediting_265954 | chr11_64228812_+ | intronic |
| ADediting_265955 | chr11_64228813_+ | intronic |
| ADediting_265956 | chr11_64228815_+ | intronic |
| ADediting_265957 | chr11_64228825_+ | intronic |
| ADediting_265958 | chr11_64228851_+ | intronic |
| ADediting_265959 | chr11_64228852_+ | intronic |
| ADediting_265960 | chr11_64228857_+ | intronic |
| ADediting_265961 | chr11_64228878_+ | intronic |
| ADediting_265962 | chr11_64228904_+ | intronic |
| ADediting_265963 | chr11_64228913_+ | intronic |
| ADediting_265964 | chr11_64228917_+ | intronic |
| ADediting_265965 | chr11_64228924_+ | intronic |
| ADediting_265966 | chr11_64228942_+ | intronic |
| ADediting_265967 | chr11_64228967_+ | intronic |
| ADediting_265968 | chr11_64228977_+ | intronic |
| ADediting_265969 | chr11_64228991_+ | intronic |
| ADediting_1527618 | chr11_64228233_+ | intronic |
| ADediting_1527619 | chr11_64228263_+ | intronic |
| ADediting_1527620 | chr11_64228922_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_265916 | chr11_64227889_+ | SINE | Alu | Name=AluY |
| ADediting_265917 | chr11_64227893_+ | SINE | Alu | Name=AluY |
| ADediting_265918 | chr11_64227921_+ | SINE | Alu | Name=AluY |
| ADediting_265919 | chr11_64227944_+ | SINE | Alu | Name=AluY |
| ADediting_265920 | chr11_64227956_+ | SINE | Alu | Name=AluY |
| ADediting_265921 | chr11_64227982_+ | SINE | Alu | Name=AluY |
| ADediting_265922 | chr11_64228009_+ | SINE | Alu | Name=AluY |
| ADediting_265923 | chr11_64228053_+ | SINE | Alu | Name=AluY |
| ADediting_265924 | chr11_64228056_+ | SINE | Alu | Name=AluY |
| ADediting_265925 | chr11_64228070_+ | SINE | Alu | Name=AluY |
| ADediting_265926 | chr11_64228078_+ | SINE | Alu | Name=AluY |
| ADediting_265927 | chr11_64228123_+ | SINE | Alu | Name=AluY |
| ADediting_265928 | chr11_64228131_+ | SINE | Alu | Name=AluY |
| ADediting_265929 | chr11_64228132_+ | SINE | Alu | Name=AluY |
| ADediting_265930 | chr11_64228133_+ | SINE | Alu | Name=AluY |
| ADediting_265931 | chr11_64228145_+ | SINE | Alu | Name=AluY |
| ADediting_265932 | chr11_64228208_+ | SINE | Alu | Name=AluSz6 |
| ADediting_265933 | chr11_64228283_+ | SINE | Alu | Name=AluSz6 |
| ADediting_265934 | chr11_64228410_+ | SINE | Alu | Name=AluY |
| ADediting_265935 | chr11_64228432_+ | SINE | Alu | Name=AluY |
| ADediting_265936 | chr11_64228447_+ | SINE | Alu | Name=AluY |
| ADediting_265937 | chr11_64228462_+ | SINE | Alu | Name=AluY |
| ADediting_265938 | chr11_64228476_+ | SINE | Alu | Name=AluY |
| ADediting_265939 | chr11_64228477_+ | SINE | Alu | Name=AluY |
| ADediting_265940 | chr11_64228487_+ | SINE | Alu | Name=AluY |
| ADediting_265941 | chr11_64228501_+ | SINE | Alu | Name=AluY |
| ADediting_265942 | chr11_64228502_+ | SINE | Alu | Name=AluY |
| ADediting_265943 | chr11_64228507_+ | SINE | Alu | Name=AluY |
| ADediting_265944 | chr11_64228517_+ | SINE | Alu | Name=AluY |
| ADediting_265945 | chr11_64228543_+ | SINE | Alu | Name=AluY |
| ADediting_265946 | chr11_64228570_+ | SINE | Alu | Name=AluY |
| ADediting_265947 | chr11_64228647_+ | SINE | Alu | Name=AluY |
| ADediting_265948 | chr11_64228709_+ | SINE | Alu | Name=AluSx |
| ADediting_265949 | chr11_64228761_+ | SINE | Alu | Name=AluSx |
| ADediting_265950 | chr11_64228784_+ | SINE | Alu | Name=AluSx |
| ADediting_265951 | chr11_64228785_+ | SINE | Alu | Name=AluSx |
| ADediting_265952 | chr11_64228809_+ | SINE | Alu | Name=AluSx |
| ADediting_265953 | chr11_64228810_+ | SINE | Alu | Name=AluSx |
| ADediting_265954 | chr11_64228812_+ | SINE | Alu | Name=AluSx |
| ADediting_265955 | chr11_64228813_+ | SINE | Alu | Name=AluSx |
| ADediting_265956 | chr11_64228815_+ | SINE | Alu | Name=AluSx |
| ADediting_265957 | chr11_64228825_+ | SINE | Alu | Name=AluSx |
| ADediting_265958 | chr11_64228851_+ | SINE | Alu | Name=AluSx |
| ADediting_265959 | chr11_64228852_+ | SINE | Alu | Name=AluSx |
| ADediting_265960 | chr11_64228857_+ | SINE | Alu | Name=AluSx |
| ADediting_265961 | chr11_64228878_+ | SINE | Alu | Name=AluSx |
| ADediting_265962 | chr11_64228904_+ | SINE | Alu | Name=AluSx |
| ADediting_265963 | chr11_64228913_+ | SINE | Alu | Name=AluSx |
| ADediting_265964 | chr11_64228917_+ | SINE | Alu | Name=AluSx |
| ADediting_265965 | chr11_64228924_+ | SINE | Alu | Name=AluSx |
| ADediting_265966 | chr11_64228942_+ | SINE | Alu | Name=AluSx |
| ADediting_265967 | chr11_64228967_+ | SINE | Alu | Name=AluSx |
| ADediting_265968 | chr11_64228977_+ | SINE | Alu | Name=AluSx |
| ADediting_265969 | chr11_64228991_+ | SINE | Alu | Name=AluSx |
| ADediting_1527618 | chr11_64228233_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1527619 | chr11_64228263_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1527620 | chr11_64228922_+ | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for NUDT22 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NUDT22 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for NUDT22 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for NUDT22 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for NUDT22 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000428347.2 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_265914 | ENST00000428347.2 | chr11_64227484_+ | 608 | -387.80 | -384.50 | -387.80 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for NUDT22 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_265920 | chr11_64227956_+ | 0.00498704213089168 | 0.159101956827344 | 0.0501734356729866 | 0.111338036152729 | 4.66997608488844e-11 | 0.362458685470301 |
| DLPFC | ADediting_265921 | chr11_64227982_+ | 0.00186479447168716 | 0.176020243379666 | 0.010695341998623 | 0.144792355331229 | 1.11121917171542e-09 | 0.337208833314134 |
| DLPFC | ADediting_265922 | chr11_64228009_+ | 0.00125133343425006 | 0.182472404811909 | 0.0529096824110745 | 0.110048389870089 | 1.55901816483861e-12 | 0.387287415642367 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.09355357270541e-19 | 0.484912188424842 | 1.05859665428403e-15 | 0.434434899636646 | 1.49292299598746e-48 | 0.70854505315554 |
| AC | 2.66611524537276e-34 | 0.672742430962665 | 3.70106464667914e-25 | 0.593243900215509 | 2.72695830533129e-26 | 0.604427631277617 |
| PCC | 1.75965055800518e-18 | 0.578894753542164 | 3.24686320348382e-24 | 0.648948528740106 | 0.00182052940220915 | 0.224206500083919 |
| TCX | 2.9698414880908e-06 | 0.370941463790982 | 3.98298297680746e-05 | 0.328828425480834 | 0.202170416212533 | 0.104724821086774 |
| FP | 1.15992799862524e-15 | 0.553262452188555 | 1.5470636220363e-21 | 0.635658736839583 | 0.0030984695905454 | 0.220514155193941 |
| IFG | 2.06586780996463e-06 | 0.794917226653916 | 2.37303024998147e-06 | 0.79216718071061 | 0.15324503300629 | 0.294328651706226 |
| STG | 1.54283009952426e-14 | 0.717825566195364 | 1.72255635944857e-12 | 0.675982725721082 | 0.127401304581329 | 0.167661388034642 |
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Relation with AD stages for NUDT22 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for NUDT22 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NUDT22 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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