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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for DDI2

check button Gene summary
Gene informationGene symbol

DDI2

Gene ID

84301

Gene nameDNA damage inducible 1 homolog 2
Synonyms-
Cytomap

1p36.21

Type of geneprotein-coding
Descriptionprotein DDI1 homolog 2DDI1, DNA-damage inducible 1, homolog 2DNA-damage inducible protein 2 (DDI2)
Modification date20200313
UniProtAcc

Q5TDH0,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
DDI2

GO:0016485

protein processing

27528193


Top

RNA A-to-I events for DDI2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_34747(15629338, +), ADediting_34748(15629386, +), ADediting_34749(15629397, +), ADediting_34750(15629425, +), ADediting_34751(15629522, +), ADediting_34752(15629580, +), ADediting_34753(15629788, +), ADediting_34754(15629806, +), ADediting_34755(15629812, +), ADediting_34756(15629818, +), ADediting_34757(15629831, +), ADediting_34758(15629849, +), ADediting_34759(15629871, +), ADediting_34760(15629915, +), ADediting_34761(15629921, +), ADediting_34762(15629966, +), ADediting_34763(15629979, +), ADediting_34764(15629994, +), ADediting_34917(15635045, +), ADediting_34918(15635046, +), ADediting_34920(15635063, +), ADediting_34921(15635065, +), ADediting_34922(15635066, +), ADediting_34923(15635068, +), ADediting_34924(15635072, +), ADediting_34925(15635073, +), ADediting_34926(15635086, +), ADediting_34927(15635108, +), ADediting_34928(15635118, +), ADediting_34929(15635122, +), ADediting_34930(15635139, +), ADediting_34931(15635144, +), ADediting_34932(15635154, +), ADediting_34933(15635170, +), ADediting_34934(15635173, +), ADediting_34935(15635178, +), ADediting_34936(15635186, +), ADediting_34937(15635200, +), ADediting_34938(15635208, +), ADediting_34940(15635425, +), ADediting_34941(15635461, +), ADediting_34942(15635467, +), ADediting_34943(15635500, +), ADediting_34944(15635506, +), ADediting_34945(15635535, +), ADediting_34946(15635545, +), ADediting_34947(15635585, +), ADediting_34948(15636222, +), ADediting_34953(15637630, +), ADediting_34954(15638635, +), ADediting_34955(15638646, +), ADediting_34956(15638674, +), ADediting_34957(15639745, +), ADediting_34958(15639817, +), ADediting_34959(15639849, +), ADediting_34960(15639881, +), ADediting_34961(15639885, +), ADediting_34962(15639887, +), ADediting_35114(15641209, +), ADediting_35115(15641271, +), ADediting_35117(15641351, +), ADediting_35118(15641352, +), ADediting_35121(15642686, +), ADediting_35123(15642884, +), ADediting_35124(15642946, +), ADediting_35125(15643037, +), ADediting_35126(15644970, +), ADediting_35127(15645129, +), ADediting_35134(15645771, +), ADediting_35216(15647211, +), ADediting_35217(15647212, +), ADediting_35218(15647222, +), ADediting_35219(15647228, +), ADediting_35220(15647241, +), ADediting_35221(15647248, +), ADediting_35223(15647265, +), ADediting_35226(15647277, +), ADediting_35232(15647287, +), ADediting_35248(15647401, +), ADediting_35249(15647411, +), ADediting_35274(15647728, +), ADediting_35275(15647729, +), ADediting_35276(15647737, +), ADediting_35277(15647752, +), ADediting_35278(15647780, +), ADediting_35279(15647786, +), ADediting_35280(15647857, +), ADediting_35281(15647871, +), ADediting_35282(15647879, +), ADediting_35283(15647896, +), ADediting_35284(15647898, +), ADediting_35286(15651038, +), ADediting_35287(15651060, +), ADediting_35290(15652097, +), ADediting_35291(15652174, +), ADediting_35292(15652175, +), ADediting_35293(15652178, +), ADediting_35294(15652187, +), ADediting_35295(15652192, +), ADediting_35296(15652225, +), ADediting_35297(15652232, +), ADediting_35298(15652238, +), ADediting_35299(15652241, +), ADediting_35300(15652247, +), ADediting_35301(15652267, +), ADediting_35302(15652273, +), ADediting_35303(15652293, +), ADediting_35304(15652332, +), ADediting_35305(15652524, +), ADediting_35306(15652568, +), ADediting_35307(15652569, +), ADediting_35308(15652657, +), ADediting_35309(15652729, +), ADediting_35310(15652742, +), ADediting_35312(15652743, +), ADediting_35313(15652744, +), ADediting_35314(15652802, +), ADediting_35315(15652911, +), ADediting_35316(15652925, +), ADediting_35317(15652926, +), ADediting_35318(15653571, +), ADediting_35319(15653576, +), ADediting_35320(15654419, +), ADediting_35321(15654420, +), ADediting_35322(15654424, +), ADediting_35323(15654433, +), ADediting_35324(15654471, +), ADediting_35325(15654515, +), ADediting_35326(15654533, +), ADediting_35327(15654541, +), ADediting_35328(15654571, +), ADediting_35329(15654575, +), ADediting_35330(15654576, +), ADediting_35331(15655370, +), ADediting_35332(15655399, +), ADediting_35333(15655405, +), ADediting_35334(15655409, +), ADediting_35335(15655497, +), ADediting_35336(15655533, +), ADediting_35337(15655569, +), ADediting_35338(15655588, +), ADediting_35339(15655600, +), ADediting_35340(15655606, +), ADediting_35341(15655674, +), ADediting_35342(15655703, +), ADediting_35343(15655710, +), ADediting_35344(15656076, +), ADediting_35345(15658230, +), ADediting_35346(15658250, +), ADediting_35347(15658253, +), ADediting_35348(15658262, +), ADediting_35349(15658279, +), ADediting_35350(15658316, +), ADediting_35351(15658330, +), ADediting_35352(15658333, +), ADediting_35353(15658384, +), ADediting_35354(15658411, +), ADediting_35355(15658507, +), ADediting_35356(15658508, +), ADediting_35357(15658513, +), ADediting_35358(15658524, +), ADediting_35359(15658553, +), ADediting_35360(15658554, +), ADediting_35361(15658577, +), ADediting_35362(15658587, +), ADediting_35363(15658602, +), ADediting_35364(15658610, +), ADediting_35365(15658615, +), ADediting_35366(15658641, +), ADediting_35367(15658660, +), ADediting_35368(15658666, +), ADediting_35369(15658742, +), ADediting_35394(15664087, +), ADediting_35395(15665142, +), ADediting_35396(15667148, +), ADediting_1515841(15665115, +), ADediting_1515842(15665252, +), ADediting_1596657(15629503, +), ADediting_1596658(15629509, +), ADediting_1596659(15629518, +), ADediting_1596660(15629529, +), ADediting_1596661(15629547, +), ADediting_1596662(15629873, +), ADediting_1596663(15629887, +), ADediting_1596664(15629897, +), ADediting_1596665(15629898, +), ADediting_1596666(15629906, +), ADediting_1596667(15629908, +), ADediting_1596668(15629929, +), ADediting_1596669(15629941, +), ADediting_1596670(15629993, +), ADediting_1596671(15639581, +), ADediting_1596672(15639603, +), ADediting_1596673(15639605, +), ADediting_1596675(15652955, +), ADediting_1596676(15652962, +), ADediting_1596677(15653381, +), ADediting_1596678(15653681, +), ADediting_1596679(15653697, +), ADediting_1596680(15658543, +),

Top

RNA editing positional annotations for DDI2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_34747chr1_15629338_+intronic
ADediting_34748chr1_15629386_+intronic
ADediting_34749chr1_15629397_+intronic
ADediting_34750chr1_15629425_+intronic
ADediting_34751chr1_15629522_+intronic
ADediting_34752chr1_15629580_+intronic
ADediting_34753chr1_15629788_+intronic
ADediting_34754chr1_15629806_+intronic
ADediting_34755chr1_15629812_+intronic
ADediting_34756chr1_15629818_+intronic
ADediting_34757chr1_15629831_+intronic
ADediting_34758chr1_15629849_+intronic
ADediting_34759chr1_15629871_+intronic
ADediting_34760chr1_15629915_+intronic
ADediting_34761chr1_15629921_+intronic
ADediting_34762chr1_15629966_+intronic
ADediting_34763chr1_15629979_+intronic
ADediting_34764chr1_15629994_+intronic
ADediting_34917chr1_15635045_+intronic
ADediting_34918chr1_15635046_+intronic
ADediting_34920chr1_15635063_+intronic
ADediting_34921chr1_15635065_+intronic
ADediting_34922chr1_15635066_+intronic
ADediting_34923chr1_15635068_+intronic
ADediting_34924chr1_15635072_+intronic
ADediting_34925chr1_15635073_+intronic
ADediting_34926chr1_15635086_+intronic
ADediting_34927chr1_15635108_+intronic
ADediting_34928chr1_15635118_+intronic
ADediting_34929chr1_15635122_+intronic
ADediting_34930chr1_15635139_+intronic
ADediting_34931chr1_15635144_+intronic
ADediting_34932chr1_15635154_+intronic
ADediting_34933chr1_15635170_+intronic
ADediting_34934chr1_15635173_+intronic
ADediting_34935chr1_15635178_+intronic
ADediting_34936chr1_15635186_+intronic
ADediting_34937chr1_15635200_+intronic
ADediting_34938chr1_15635208_+intronic
ADediting_34940chr1_15635425_+intronic
ADediting_34941chr1_15635461_+intronic
ADediting_34942chr1_15635467_+intronic
ADediting_34943chr1_15635500_+intronic
ADediting_34944chr1_15635506_+intronic
ADediting_34945chr1_15635535_+intronic
ADediting_34946chr1_15635545_+intronic
ADediting_34947chr1_15635585_+intronic
ADediting_34948chr1_15636222_+intronic
ADediting_34953chr1_15637630_+intronic
ADediting_34954chr1_15638635_+intronic
ADediting_34955chr1_15638646_+intronic
ADediting_34956chr1_15638674_+intronic
ADediting_34957chr1_15639745_+intronic
ADediting_34958chr1_15639817_+intronic
ADediting_34959chr1_15639849_+intronic
ADediting_34960chr1_15639881_+intronic
ADediting_34961chr1_15639885_+intronic
ADediting_34962chr1_15639887_+intronic
ADediting_35114chr1_15641209_+intronic
ADediting_35115chr1_15641271_+intronic
ADediting_35117chr1_15641351_+intronic
ADediting_35118chr1_15641352_+intronic
ADediting_35121chr1_15642686_+intronic
ADediting_35123chr1_15642884_+intronic
ADediting_35124chr1_15642946_+intronic
ADediting_35125chr1_15643037_+intronic
ADediting_35126chr1_15644970_+intronic
ADediting_35127chr1_15645129_+intronic
ADediting_35134chr1_15645771_+intronic
ADediting_35216chr1_15647211_+intronic
ADediting_35217chr1_15647212_+intronic
ADediting_35218chr1_15647222_+intronic
ADediting_35219chr1_15647228_+intronic
ADediting_35220chr1_15647241_+intronic
ADediting_35221chr1_15647248_+intronic
ADediting_35223chr1_15647265_+intronic
ADediting_35226chr1_15647277_+intronic
ADediting_35232chr1_15647287_+intronic
ADediting_35248chr1_15647401_+intronic
ADediting_35249chr1_15647411_+intronic
ADediting_35274chr1_15647728_+intronic
ADediting_35275chr1_15647729_+intronic
ADediting_35276chr1_15647737_+intronic
ADediting_35277chr1_15647752_+intronic
ADediting_35278chr1_15647780_+intronic
ADediting_35279chr1_15647786_+intronic
ADediting_35280chr1_15647857_+intronic
ADediting_35281chr1_15647871_+intronic
ADediting_35282chr1_15647879_+intronic
ADediting_35283chr1_15647896_+intronic
ADediting_35284chr1_15647898_+intronic
ADediting_35286chr1_15651038_+intronic
ADediting_35287chr1_15651060_+intronic
ADediting_35290chr1_15652097_+intronic
ADediting_35291chr1_15652174_+intronic
ADediting_35292chr1_15652175_+intronic
ADediting_35293chr1_15652178_+intronic
ADediting_35294chr1_15652187_+intronic
ADediting_35295chr1_15652192_+intronic
ADediting_35296chr1_15652225_+intronic
ADediting_35297chr1_15652232_+intronic
ADediting_35298chr1_15652238_+intronic
ADediting_35299chr1_15652241_+intronic
ADediting_35300chr1_15652247_+intronic
ADediting_35301chr1_15652267_+intronic
ADediting_35302chr1_15652273_+intronic
ADediting_35303chr1_15652293_+intronic
ADediting_35304chr1_15652332_+intronic
ADediting_35305chr1_15652524_+intronic
ADediting_35306chr1_15652568_+intronic
ADediting_35307chr1_15652569_+intronic
ADediting_35308chr1_15652657_+intronic
ADediting_35309chr1_15652729_+intronic
ADediting_35310chr1_15652742_+intronic
ADediting_35312chr1_15652743_+intronic
ADediting_35313chr1_15652744_+intronic
ADediting_35314chr1_15652802_+intronic
ADediting_35315chr1_15652911_+intronic
ADediting_35316chr1_15652925_+intronic
ADediting_35317chr1_15652926_+intronic
ADediting_35318chr1_15653571_+intronic
ADediting_35319chr1_15653576_+intronic
ADediting_35320chr1_15654419_+intronic
ADediting_35321chr1_15654420_+intronic
ADediting_35322chr1_15654424_+intronic
ADediting_35323chr1_15654433_+intronic
ADediting_35324chr1_15654471_+intronic
ADediting_35325chr1_15654515_+intronic
ADediting_35326chr1_15654533_+intronic
ADediting_35327chr1_15654541_+intronic
ADediting_35328chr1_15654571_+intronic
ADediting_35329chr1_15654575_+intronic
ADediting_35330chr1_15654576_+intronic
ADediting_35331chr1_15655370_+intronic
ADediting_35332chr1_15655399_+intronic
ADediting_35333chr1_15655405_+intronic
ADediting_35334chr1_15655409_+intronic
ADediting_35335chr1_15655497_+intronic
ADediting_35336chr1_15655533_+intronic
ADediting_35337chr1_15655569_+intronic
ADediting_35338chr1_15655588_+intronic
ADediting_35339chr1_15655600_+intronic
ADediting_35340chr1_15655606_+intronic
ADediting_35341chr1_15655674_+intronic
ADediting_35342chr1_15655703_+intronic
ADediting_35343chr1_15655710_+intronic
ADediting_35344chr1_15656076_+intronic
ADediting_35345chr1_15658230_+intronic
ADediting_35346chr1_15658250_+intronic
ADediting_35347chr1_15658253_+intronic
ADediting_35348chr1_15658262_+intronic
ADediting_35349chr1_15658279_+intronic
ADediting_35350chr1_15658316_+intronic
ADediting_35351chr1_15658330_+intronic
ADediting_35352chr1_15658333_+intronic
ADediting_35353chr1_15658384_+intronic
ADediting_35354chr1_15658411_+intronic
ADediting_35355chr1_15658507_+intronic
ADediting_35356chr1_15658508_+intronic
ADediting_35357chr1_15658513_+intronic
ADediting_35358chr1_15658524_+intronic
ADediting_35359chr1_15658553_+intronic
ADediting_35360chr1_15658554_+intronic
ADediting_35361chr1_15658577_+intronic
ADediting_35362chr1_15658587_+intronic
ADediting_35363chr1_15658602_+intronic
ADediting_35364chr1_15658610_+intronic
ADediting_35365chr1_15658615_+intronic
ADediting_35366chr1_15658641_+intronic
ADediting_35367chr1_15658660_+intronic
ADediting_35368chr1_15658666_+intronic
ADediting_35369chr1_15658742_+intronic
ADediting_35394chr1_15664087_+UTR3
ADediting_35395chr1_15665142_+UTR3
ADediting_35396chr1_15667148_+UTR3
ADediting_1515841chr1_15665115_+UTR3
ADediting_1515842chr1_15665252_+UTR3
ADediting_1596657chr1_15629503_+intronic
ADediting_1596658chr1_15629509_+intronic
ADediting_1596659chr1_15629518_+intronic
ADediting_1596660chr1_15629529_+intronic
ADediting_1596661chr1_15629547_+intronic
ADediting_1596662chr1_15629873_+intronic
ADediting_1596663chr1_15629887_+intronic
ADediting_1596664chr1_15629897_+intronic
ADediting_1596665chr1_15629898_+intronic
ADediting_1596666chr1_15629906_+intronic
ADediting_1596667chr1_15629908_+intronic
ADediting_1596668chr1_15629929_+intronic
ADediting_1596669chr1_15629941_+intronic
ADediting_1596670chr1_15629993_+intronic
ADediting_1596671chr1_15639581_+intronic
ADediting_1596672chr1_15639603_+intronic
ADediting_1596673chr1_15639605_+intronic
ADediting_1596675chr1_15652955_+intronic
ADediting_1596676chr1_15652962_+intronic
ADediting_1596677chr1_15653381_+intronic
ADediting_1596678chr1_15653681_+intronic
ADediting_1596679chr1_15653697_+intronic
ADediting_1596680chr1_15658543_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_34747chr1_15629338_+SINEAluName=AluSx
ADediting_34748chr1_15629386_+SINEAluName=AluSx
ADediting_34749chr1_15629397_+SINEAluName=AluSx
ADediting_34750chr1_15629425_+SINEAluName=AluSx
ADediting_34751chr1_15629522_+SINEAluName=AluSx
ADediting_34752chr1_15629580_+SINEAluName=AluSx
ADediting_34753chr1_15629788_+SINEAluName=AluSq2
ADediting_34754chr1_15629806_+SINEAluName=AluSq2
ADediting_34755chr1_15629812_+SINEAluName=AluSq2
ADediting_34756chr1_15629818_+SINEAluName=AluSq2
ADediting_34757chr1_15629831_+SINEAluName=AluSq2
ADediting_34758chr1_15629849_+SINEAluName=AluSq2
ADediting_34759chr1_15629871_+SINEAluName=AluSq2
ADediting_34760chr1_15629915_+SINEAluName=AluSq2
ADediting_34761chr1_15629921_+SINEAluName=AluSq2
ADediting_34762chr1_15629966_+SINEAluName=AluSq2
ADediting_34763chr1_15629979_+SINEAluName=AluSq2
ADediting_34764chr1_15629994_+SINEAluName=AluSq2
ADediting_34917chr1_15635045_+SINEAluName=AluJr
ADediting_34918chr1_15635046_+SINEAluName=AluJr
ADediting_34920chr1_15635063_+SINEAluName=AluJr
ADediting_34921chr1_15635065_+SINEAluName=AluJr
ADediting_34922chr1_15635066_+SINEAluName=AluJr
ADediting_34923chr1_15635068_+SINEAluName=AluJr
ADediting_34924chr1_15635072_+SINEAluName=AluJr
ADediting_34925chr1_15635073_+SINEAluName=AluJr
ADediting_34926chr1_15635086_+SINEAluName=AluJr
ADediting_34927chr1_15635108_+SINEAluName=AluJr
ADediting_34928chr1_15635118_+SINEAluName=AluJr
ADediting_34929chr1_15635122_+SINEAluName=AluJr
ADediting_34930chr1_15635139_+SINEAluName=AluJr
ADediting_34931chr1_15635144_+SINEAluName=AluJr
ADediting_34932chr1_15635154_+SINEAluName=AluJr
ADediting_34933chr1_15635170_+SINEAluName=AluJr
ADediting_34934chr1_15635173_+SINEAluName=AluJr
ADediting_34935chr1_15635178_+SINEAluName=AluJr
ADediting_34936chr1_15635186_+SINEAluName=AluJr
ADediting_34937chr1_15635200_+SINEAluName=AluJr
ADediting_34938chr1_15635208_+SINEAluName=AluJr
ADediting_34940chr1_15635425_+SINEAluName=AluSx
ADediting_34941chr1_15635461_+SINEAluName=AluSx
ADediting_34942chr1_15635467_+SINEAluName=AluSx
ADediting_34943chr1_15635500_+SINEAluName=AluSx
ADediting_34944chr1_15635506_+SINEAluName=AluSx
ADediting_34945chr1_15635535_+SINEAluName=AluSx
ADediting_34946chr1_15635545_+SINEAluName=AluSx
ADediting_34947chr1_15635585_+SINEAluName=AluSx
ADediting_34948chr1_15636222_+SINEAluName=AluJb
ADediting_34953chr1_15637630_+SINEAluName=AluSx
ADediting_34954chr1_15638635_+SINEAluName=AluSx1
ADediting_34955chr1_15638646_+SINEAluName=AluSx1
ADediting_34956chr1_15638674_+SINEAluName=AluSx1
ADediting_34957chr1_15639745_+SINEAluName=AluJb
ADediting_34958chr1_15639817_+SINEAluName=AluJb
ADediting_34959chr1_15639849_+SINEAluName=AluJb
ADediting_34960chr1_15639881_+SINEAluName=AluJb
ADediting_34961chr1_15639885_+SINEAluName=AluJb
ADediting_34962chr1_15639887_+SINEAluName=AluJb
ADediting_35114chr1_15641209_+SINEAluName=AluSz
ADediting_35115chr1_15641271_+SINEAluName=AluSz
ADediting_35117chr1_15641351_+SINEAluName=AluSz
ADediting_35118chr1_15641352_+SINEAluName=AluSz
ADediting_35121chr1_15642686_+SINEAluName=AluSz
ADediting_35123chr1_15642884_+SINEAluName=AluY
ADediting_35124chr1_15642946_+SINEAluName=AluY
ADediting_35125chr1_15643037_+SINEAluName=AluY
ADediting_35126chr1_15644970_+SINEAluName=AluSz
ADediting_35127chr1_15645129_+SINEAluName=AluSz
ADediting_35134chr1_15645771_+SINEAluName=AluJr
ADediting_35216chr1_15647211_+SINEAluName=AluSx1
ADediting_35217chr1_15647212_+SINEAluName=AluSx1
ADediting_35218chr1_15647222_+SINEAluName=AluSx1
ADediting_35219chr1_15647228_+SINEAluName=AluSx1
ADediting_35220chr1_15647241_+SINEAluName=AluSx1
ADediting_35221chr1_15647248_+SINEAluName=AluSx1
ADediting_35223chr1_15647265_+SINEAluName=AluSx1
ADediting_35226chr1_15647277_+SINEAluName=AluSx1
ADediting_35232chr1_15647287_+SINEAluName=AluSx1
ADediting_35248chr1_15647401_+SINEAluName=AluSx1
ADediting_35249chr1_15647411_+SINEAluName=AluSx1
ADediting_35274chr1_15647728_+SINEAluName=AluSx3
ADediting_35275chr1_15647729_+SINEAluName=AluSx3
ADediting_35276chr1_15647737_+SINEAluName=AluSx3
ADediting_35277chr1_15647752_+SINEAluName=AluSx3
ADediting_35278chr1_15647780_+SINEAluName=AluSx3
ADediting_35279chr1_15647786_+SINEAluName=AluSx3
ADediting_35280chr1_15647857_+SINEAluName=AluSx3
ADediting_35281chr1_15647871_+SINEAluName=AluSx3
ADediting_35282chr1_15647879_+SINEAluName=AluSx3
ADediting_35283chr1_15647896_+SINEAluName=AluSx3
ADediting_35284chr1_15647898_+SINEAluName=AluSx3
ADediting_35286chr1_15651038_+SINEAluName=AluY
ADediting_35287chr1_15651060_+SINEAluName=AluY
ADediting_35290chr1_15652097_+SINEAluName=AluJo
ADediting_35291chr1_15652174_+SINEAluName=AluJo
ADediting_35292chr1_15652175_+SINEAluName=AluJo
ADediting_35293chr1_15652178_+SINEAluName=AluJo
ADediting_35294chr1_15652187_+SINEAluName=AluJo
ADediting_35295chr1_15652192_+SINEAluName=AluJo
ADediting_35296chr1_15652225_+SINEAluName=AluJo
ADediting_35297chr1_15652232_+SINEAluName=AluJo
ADediting_35298chr1_15652238_+SINEAluName=AluJo
ADediting_35299chr1_15652241_+SINEAluName=AluJo
ADediting_35300chr1_15652247_+SINEAluName=AluJo
ADediting_35301chr1_15652267_+SINEAluName=AluJo
ADediting_35302chr1_15652273_+SINEAluName=AluJo
ADediting_35303chr1_15652293_+SINEAluName=AluJo
ADediting_35304chr1_15652332_+SINEAluName=AluJo
ADediting_35305chr1_15652524_+SINEAluName=AluSx
ADediting_35306chr1_15652568_+SINEAluName=AluY
ADediting_35307chr1_15652569_+SINEAluName=AluY
ADediting_35308chr1_15652657_+SINEAluName=AluY
ADediting_35309chr1_15652729_+SINEAluName=AluY
ADediting_35310chr1_15652742_+SINEAluName=AluY
ADediting_35312chr1_15652743_+SINEAluName=AluY
ADediting_35313chr1_15652744_+SINEAluName=AluY
ADediting_35314chr1_15652802_+SINEAluName=AluY
ADediting_35315chr1_15652911_+SINEAluName=AluSx
ADediting_35316chr1_15652925_+SINEAluName=AluSx
ADediting_35317chr1_15652926_+SINEAluName=AluSx
ADediting_35318chr1_15653571_+SINEAluName=AluSz6
ADediting_35319chr1_15653576_+SINEAluName=AluSz6
ADediting_35320chr1_15654419_+SINEAluName=AluJb
ADediting_35321chr1_15654420_+SINEAluName=AluJb
ADediting_35322chr1_15654424_+SINEAluName=AluJb
ADediting_35323chr1_15654433_+SINEAluName=AluJb
ADediting_35324chr1_15654471_+SINEAluName=AluJb
ADediting_35325chr1_15654515_+SINEAluName=AluJb
ADediting_35326chr1_15654533_+SINEAluName=AluJb
ADediting_35327chr1_15654541_+SINEAluName=AluJb
ADediting_35328chr1_15654571_+SINEAluName=AluJb
ADediting_35329chr1_15654575_+SINEAluName=AluJb
ADediting_35330chr1_15654576_+SINEAluName=AluJb
ADediting_35331chr1_15655370_+SINEAluName=AluJb
ADediting_35332chr1_15655399_+SINEAluName=AluJb
ADediting_35333chr1_15655405_+SINEAluName=AluJb
ADediting_35334chr1_15655409_+SINEAluName=AluJb
ADediting_35335chr1_15655497_+SINEAluName=AluSx1
ADediting_35336chr1_15655533_+SINEAluName=AluSx1
ADediting_35337chr1_15655569_+SINEAluName=AluSx1
ADediting_35338chr1_15655588_+SINEAluName=AluSx1
ADediting_35339chr1_15655600_+SINEAluName=AluSx1
ADediting_35340chr1_15655606_+SINEAluName=AluSx1
ADediting_35341chr1_15655674_+SINEAluName=AluSx1
ADediting_35342chr1_15655703_+SINEAluName=AluSx1
ADediting_35343chr1_15655710_+SINEAluName=AluSx1
ADediting_35344chr1_15656076_+SINEAluName=AluJr
ADediting_35345chr1_15658230_+SINEAluName=AluSx1
ADediting_35346chr1_15658250_+SINEAluName=AluSx1
ADediting_35347chr1_15658253_+SINEAluName=AluSx1
ADediting_35348chr1_15658262_+SINEAluName=AluSx1
ADediting_35349chr1_15658279_+SINEAluName=AluSx1
ADediting_35350chr1_15658316_+SINEAluName=AluSx1
ADediting_35351chr1_15658330_+SINEAluName=AluSx1
ADediting_35352chr1_15658333_+SINEAluName=AluSx1
ADediting_35353chr1_15658384_+SINEAluName=AluSx1
ADediting_35354chr1_15658411_+SINEAluName=AluSx1
ADediting_35355chr1_15658507_+SINEAluName=AluSp
ADediting_35356chr1_15658508_+SINEAluName=AluSp
ADediting_35357chr1_15658513_+SINEAluName=AluSp
ADediting_35358chr1_15658524_+SINEAluName=AluSp
ADediting_35359chr1_15658553_+SINEAluName=AluSp
ADediting_35360chr1_15658554_+SINEAluName=AluSp
ADediting_35361chr1_15658577_+SINEAluName=AluSp
ADediting_35362chr1_15658587_+SINEAluName=AluSp
ADediting_35363chr1_15658602_+SINEAluName=AluSp
ADediting_35364chr1_15658610_+SINEAluName=AluSp
ADediting_35365chr1_15658615_+SINEAluName=AluSp
ADediting_35366chr1_15658641_+SINEAluName=AluSp
ADediting_35367chr1_15658660_+SINEAluName=AluSp
ADediting_35368chr1_15658666_+SINEAluName=AluSp
ADediting_35369chr1_15658742_+SINEAluName=AluSp
ADediting_35394chr1_15664087_+SINEAluName=FLAM_C
ADediting_35395chr1_15665142_+SINEAluName=AluSq2
ADediting_35396chr1_15667148_+SINEAluName=AluSx4
ADediting_1515841chr1_15665115_+SINEAluName=AluSq2
ADediting_1515842chr1_15665252_+SINEAluName=AluSq2
ADediting_1596657chr1_15629503_+SINEAluName=AluSx
ADediting_1596658chr1_15629509_+SINEAluName=AluSx
ADediting_1596659chr1_15629518_+SINEAluName=AluSx
ADediting_1596660chr1_15629529_+SINEAluName=AluSx
ADediting_1596661chr1_15629547_+SINEAluName=AluSx
ADediting_1596662chr1_15629873_+SINEAluName=AluSq2
ADediting_1596663chr1_15629887_+SINEAluName=AluSq2
ADediting_1596664chr1_15629897_+SINEAluName=AluSq2
ADediting_1596665chr1_15629898_+SINEAluName=AluSq2
ADediting_1596666chr1_15629906_+SINEAluName=AluSq2
ADediting_1596667chr1_15629908_+SINEAluName=AluSq2
ADediting_1596668chr1_15629929_+SINEAluName=AluSq2
ADediting_1596669chr1_15629941_+SINEAluName=AluSq2
ADediting_1596670chr1_15629993_+SINEAluName=AluSq2
ADediting_1596671chr1_15639581_+SINEAluName=AluJr
ADediting_1596672chr1_15639603_+SINEAluName=AluJr
ADediting_1596673chr1_15639605_+SINEAluName=AluJr
ADediting_1596675chr1_15652955_+SINEAluName=AluSx
ADediting_1596676chr1_15652962_+SINEAluName=AluSx
ADediting_1596677chr1_15653381_+SINEAluName=AluJr
ADediting_1596678chr1_15653681_+SINEAluName=AluSz6
ADediting_1596679chr1_15653697_+SINEAluName=AluSz6
ADediting_1596680chr1_15658543_+SINEAluName=AluSp

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RNA A-to-I editing events in the alternative splicing sites for DDI2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DDI2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
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boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
Soverview
Soverview

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for DDI2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for DDI2

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1515842chr1_15665252_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-431-5pchr115665247156652537mer-m81566523415665254140-12.81
ADediting_1515842chr1_15665252_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5007-5pchr115665250156652567mer-m81566523615665257156-16.06
ADediting_1515842chr1_15665252_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-924chr115665249156652557mer-m81566523615665256150-20.16
ADediting_35394chr1_15664087_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-186-3pchr115664082156640887mer-1a1566406715664088144-19.5
ADediting_35394chr1_15664087_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-4733-5pchr115664083156640897mer-m81566406915664090151-13.28

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1515841chr1_15665115_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-4735-5pchr115665109156651157mer-m81566509515665116140-5.48
ADediting_1515842chr1_15665252_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-19b-1-5pchr115665247156652537mer-m81566523315665254149-20.04
ADediting_1515842chr1_15665252_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-19b-2-5pchr115665247156652537mer-m81566523215665254147-13.36
ADediting_35394chr1_15664087_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-371b-5pchr115664081156640888mer-1a1566406315664088145-13.74
ADediting_35394chr1_15664087_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-373-5pchr115664081156640888mer-1a1566406715664088142-10.37
ADediting_35394chr1_15664087_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-616-5pchr115664081156640888mer-1a1566406915664088144-9.06
ADediting_35395chr1_15665142_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-10399-5pchr115665136156651427mer-m81566512215665143144-10.59
ADediting_35395chr1_15665142_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-6504-3pchr115665136156651427mer-m81566512215665143148-14.28

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5688chr115664234156642407mer-m81566422015664241159-10.83
ADediting_1337757chr7_5495852_-ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-589-3pchr115662228156622347mer-m81566221015662235145-17.87
ADediting_1535951chr14_100874558_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-337-3pchr115667657156676637mer-m81566764215667664151-16.35
ADediting_1535954chr14_101045974_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-381-3pchr115663723156637297mer-m81566370915663730147-18.43
ADediting_1535954chr14_101045974_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-381-3pchr115668219156682257mer-m81566820515668226140-11.01
ADediting_1556067chr19_40282625_-ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-641chr115665426156654327mer-m81566540615665433144-17.29
ADediting_286380chr11_79422188_-ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5579-3pchr115667977156679848mer-1a1566796315667984145-12.22
ADediting_843620chr2_207754818_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-4775chr115660331156603377mer-m81566031515660338158-18.82
ADediting_843620chr2_207754818_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-4775chr115666156156661627mer-m81566614115666163161-12.79
ADediting_843620chr2_207754818_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-4775chr115666860156668667mer-m81566684515666867148-14.81

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5581-3pchr115662392156623987mer-m81566237815662399140-12.78
ADediting_1097295chr3_85385762_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5688chr115668549156685557mer-m81566853515668556140-9.57
ADediting_1337757chr7_5495852_-ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-589-3pchr115668057156680637mer-m81566803615668064148-16.26
ADediting_1391023chr8_140732605_-ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-151a-3pchr115662779156627857mer-m81566276515662786150-16.14
ADediting_1535953chr14_101045971_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-381-3pchr115668643156686497mer-m81566863015668650154-13.7
ADediting_1535954chr14_101045974_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-381-3pchr115668643156686497mer-m81566863015668650154-13.7
ADediting_1643790chr3_121049689_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5682chr115662463156624697mer-m81566244915662470143-16.48
ADediting_1643790chr3_121049689_+ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5682chr115663680156636867mer-m81566366715663687141-12.01
ADediting_286380chr11_79422188_-ENSG00000197312.12ENST00000480945.6DDI2-202hsa-miR-5579-3pchr115665597156656037mer-m81566558215665604142-10.13

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DDI2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000480945.6protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_35394ENST00000480945.6chr1_15664087_+5710-3178.50-3179.40-3196.20
ADediting_1515841ENST00000480945.6chr1_15665115_+6738-3185.20-3179.40-3196.20
ADediting_35395ENST00000480945.6chr1_15665142_+6765-3185.60-3179.40-3196.20
ADediting_1515842ENST00000480945.6chr1_15665252_+6875-3185.80-3179.40-3196.20
ADediting_35396ENST00000480945.6chr1_15667148_+8771-3178.70-3179.40-3196.20

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for DDI2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_34930chr1_15635139_+0.6383990882267280.02679415201663680.142457061085653-0.08349487103581283.91507004799026e-180.466214247375239
DLPFCADediting_34942chr1_15635467_+0.466581245877501-0.04150045597680230.0113348221163936-0.1436531221862381.80186350901418e-130.402023815394861
DLPFCADediting_35357chr1_15658513_+0.10223964128628-0.09298462066397780.00330656495288778-0.1663580438139421.15183634621237e-080.317002313920691
DLPFCADediting_35367chr1_15658660_+0.324669891801606-0.05612156132157230.00154827545263717-0.1790553618436657.33240774668737e-180.462813832705199

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC7.71323189071019e-780.8235931043491785.15136905295312e-670.7886031815300910.0002946592449044280.20425287036475
AC4.89540018797266e-430.7309244821943752.10497425068806e-360.6880769875861572.11412204241698e-110.407157748872798
PCC5.53636793437178e-490.826213049253481.56365233296978e-460.8143391946465060.0001632217867599370.269495058570473
CER2.30107675227894e-590.9126151335777857.45778594765404e-280.7454234315428540.1222439101383210.126734121550137
TCX8.32121533708607e-460.8633299454352751.47300718712562e-100.4929400836804431.04434897846548e-060.386343159849404
FP2.16379490575376e-450.8245155323343455.46752501096256e-330.7467063558909650.0002606242813785980.270484001177778
IFG1.34276580865159e-060.8032091103289760.0001766440374832380.6814104435384390.001306740855634910.606565574938245
PG6.47253437557819e-580.8682766973478261.31546072991803e-310.7249237751794250.3332749097225910.0713338239130115
STG5.12687702014227e-220.8249064154858451.58088159315559e-100.628248082573380.005171412485838370.302438012347119

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Relation with AD stages for DDI2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.0003289293602912860.339222480089229
TCX0.0002656910652389420.34722371251784

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RelatedDrugs for DDI2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DDI2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource