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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for POLDIP3

check button Gene summary
Gene informationGene symbol

POLDIP3

Gene ID

84271

Gene nameDNA polymerase delta interacting protein 3
SynonymsPDIP3|PDIP46|SKAR
Cytomap

22q13.2

Type of geneprotein-coding
Descriptionpolymerase delta-interacting protein 346 kDa DNA polymerase delta interaction proteinRNA-binding protein P46S6K1 Aly/REF-like targetpolymerase (DNA) delta interacting protein 3polymerase (DNA-directed), delta interacting protein 3
Modification date20200313
UniProtAcc

Q9BY77,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
POLDIP3

GO:0016973

poly(A)+ mRNA export from nucleus

22928037


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RNA A-to-I events for POLDIP3

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1001302(42586180, -), ADediting_1001303(42587008, -), ADediting_1001304(42587025, -), ADediting_1001305(42588266, -), ADediting_1001306(42588379, -), ADediting_1001307(42588701, -), ADediting_1001308(42588721, -), ADediting_1001309(42588725, -), ADediting_1001310(42588726, -), ADediting_1001311(42588740, -), ADediting_1001312(42588766, -), ADediting_1001313(42588767, -), ADediting_1001314(42588777, -), ADediting_1001315(42588789, -), ADediting_1001316(42588793, -), ADediting_1001317(42588798, -), ADediting_1001318(42588801, -), ADediting_1001319(42588810, -), ADediting_1001320(42588826, -), ADediting_1001321(42588832, -), ADediting_1001322(42589038, -), ADediting_1001323(42589073, -), ADediting_1001324(42589076, -), ADediting_1001325(42589079, -), ADediting_1001326(42589094, -), ADediting_1001327(42589095, -), ADediting_1001328(42589099, -), ADediting_1001329(42589121, -), ADediting_1001330(42589126, -), ADediting_1001331(42589167, -), ADediting_1001332(42589180, -), ADediting_1001333(42589186, -), ADediting_1001334(42589199, -), ADediting_1001335(42589700, -), ADediting_1001336(42589722, -), ADediting_1001337(42589744, -), ADediting_1001338(42589757, -), ADediting_1001339(42589758, -), ADediting_1001340(42589761, -), ADediting_1001341(42590277, -), ADediting_1001342(42590327, -), ADediting_1001343(42590355, -), ADediting_1001344(42590380, -), ADediting_1001345(42590396, -), ADediting_1001346(42590402, -), ADediting_1001347(42590430, -), ADediting_1001348(42590456, -), ADediting_1001349(42590820, -), ADediting_1001350(42590892, -), ADediting_1001351(42590952, -), ADediting_1001352(42590991, -), ADediting_1001353(42591011, -), ADediting_1001354(42593600, -), ADediting_1001355(42593614, -), ADediting_1001356(42593617, -), ADediting_1001357(42593621, -), ADediting_1001358(42593635, -), ADediting_1001359(42593643, -), ADediting_1001360(42593651, -), ADediting_1001361(42593687, -), ADediting_1001362(42593692, -), ADediting_1001363(42593698, -), ADediting_1001364(42593701, -), ADediting_1001365(42593715, -), ADediting_1001366(42593722, -), ADediting_1001367(42593746, -), ADediting_1001368(42593800, -), ADediting_1001369(42594005, -), ADediting_1001370(42594161, -), ADediting_1001371(42594178, -), ADediting_1001372(42594220, -), ADediting_1001373(42594306, -), ADediting_1001374(42594331, -), ADediting_1001375(42594345, -), ADediting_1001376(42594389, -), ADediting_1001377(42594399, -), ADediting_1001378(42594480, -), ADediting_1001379(42594484, -), ADediting_1001380(42596798, -), ADediting_1001381(42596801, -), ADediting_1001382(42596802, -), ADediting_1001383(42596815, -), ADediting_1001384(42597917, -), ADediting_1001385(42597918, -), ADediting_1001386(42597957, -), ADediting_1001387(42597958, -), ADediting_1001388(42597961, -), ADediting_1001389(42597982, -), ADediting_1001390(42598015, -), ADediting_1001391(42598020, -), ADediting_1001392(42598161, -), ADediting_1001393(42598221, -), ADediting_1001394(42598227, -), ADediting_1001395(42598351, -), ADediting_1001396(42598389, -), ADediting_1001397(42598411, -), ADediting_1001398(42598432, -), ADediting_1001399(42598446, -), ADediting_1001400(42598448, -), ADediting_1001401(42598457, -), ADediting_1001402(42598484, -), ADediting_1001403(42598579, -), ADediting_1001404(42598650, -), ADediting_1001405(42598679, -), ADediting_1001406(42599339, -), ADediting_1001407(42599347, -), ADediting_1001408(42599360, -), ADediting_1001409(42599400, -), ADediting_1001410(42599401, -), ADediting_1001411(42599412, -), ADediting_1001412(42599421, -), ADediting_1001413(42599438, -), ADediting_1001414(42599460, -), ADediting_1001415(42599482, -), ADediting_1001416(42599492, -), ADediting_1001417(42599504, -), ADediting_1001418(42599514, -), ADediting_1001419(42599517, -), ADediting_1001420(42599521, -), ADediting_1001421(42599522, -), ADediting_1001422(42599547, -), ADediting_1001423(42599557, -), ADediting_1001424(42599565, -), ADediting_1571219(42586466, -), ADediting_1571220(42586476, -), ADediting_1571221(42588841, -), ADediting_1571222(42589209, -), ADediting_1571223(42590286, -), ADediting_1571224(42590321, -), ADediting_1571225(42590451, -), ADediting_1571226(42590465, -), ADediting_1571227(42590950, -), ADediting_1571228(42594080, -), ADediting_1571229(42594094, -), ADediting_1571230(42594097, -), ADediting_1571231(42594104, -), ADediting_1642932(42588807, -), ADediting_1642933(42588821, -), ADediting_1642934(42596774, -),

Top

RNA editing positional annotations for POLDIP3 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1001302chr22_42586180_-intronic
ADediting_1001303chr22_42587008_-intronic
ADediting_1001304chr22_42587025_-intronic
ADediting_1001305chr22_42588266_-intronic
ADediting_1001306chr22_42588379_-intronic
ADediting_1001307chr22_42588701_-intronic
ADediting_1001308chr22_42588721_-intronic
ADediting_1001309chr22_42588725_-intronic
ADediting_1001310chr22_42588726_-intronic
ADediting_1001311chr22_42588740_-intronic
ADediting_1001312chr22_42588766_-intronic
ADediting_1001313chr22_42588767_-intronic
ADediting_1001314chr22_42588777_-intronic
ADediting_1001315chr22_42588789_-intronic
ADediting_1001316chr22_42588793_-intronic
ADediting_1001317chr22_42588798_-intronic
ADediting_1001318chr22_42588801_-intronic
ADediting_1001319chr22_42588810_-intronic
ADediting_1001320chr22_42588826_-intronic
ADediting_1001321chr22_42588832_-intronic
ADediting_1001322chr22_42589038_-intronic
ADediting_1001323chr22_42589073_-intronic
ADediting_1001324chr22_42589076_-intronic
ADediting_1001325chr22_42589079_-intronic
ADediting_1001326chr22_42589094_-intronic
ADediting_1001327chr22_42589095_-intronic
ADediting_1001328chr22_42589099_-intronic
ADediting_1001329chr22_42589121_-intronic
ADediting_1001330chr22_42589126_-intronic
ADediting_1001331chr22_42589167_-intronic
ADediting_1001332chr22_42589180_-intronic
ADediting_1001333chr22_42589186_-intronic
ADediting_1001334chr22_42589199_-intronic
ADediting_1001335chr22_42589700_-intronic
ADediting_1001336chr22_42589722_-intronic
ADediting_1001337chr22_42589744_-intronic
ADediting_1001338chr22_42589757_-intronic
ADediting_1001339chr22_42589758_-intronic
ADediting_1001340chr22_42589761_-intronic
ADediting_1001341chr22_42590277_-intronic
ADediting_1001342chr22_42590327_-intronic
ADediting_1001343chr22_42590355_-intronic
ADediting_1001344chr22_42590380_-intronic
ADediting_1001345chr22_42590396_-intronic
ADediting_1001346chr22_42590402_-intronic
ADediting_1001347chr22_42590430_-intronic
ADediting_1001348chr22_42590456_-intronic
ADediting_1001349chr22_42590820_-intronic
ADediting_1001350chr22_42590892_-intronic
ADediting_1001351chr22_42590952_-intronic
ADediting_1001352chr22_42590991_-intronic
ADediting_1001353chr22_42591011_-intronic
ADediting_1001354chr22_42593600_-intronic
ADediting_1001355chr22_42593614_-intronic
ADediting_1001356chr22_42593617_-intronic
ADediting_1001357chr22_42593621_-intronic
ADediting_1001358chr22_42593635_-intronic
ADediting_1001359chr22_42593643_-intronic
ADediting_1001360chr22_42593651_-intronic
ADediting_1001361chr22_42593687_-intronic
ADediting_1001362chr22_42593692_-intronic
ADediting_1001363chr22_42593698_-intronic
ADediting_1001364chr22_42593701_-intronic
ADediting_1001365chr22_42593715_-intronic
ADediting_1001366chr22_42593722_-intronic
ADediting_1001367chr22_42593746_-intronic
ADediting_1001368chr22_42593800_-intronic
ADediting_1001369chr22_42594005_-intronic
ADediting_1001370chr22_42594161_-intronic
ADediting_1001371chr22_42594178_-intronic
ADediting_1001372chr22_42594220_-intronic
ADediting_1001373chr22_42594306_-intronic
ADediting_1001374chr22_42594331_-intronic
ADediting_1001375chr22_42594345_-intronic
ADediting_1001376chr22_42594389_-intronic
ADediting_1001377chr22_42594399_-intronic
ADediting_1001378chr22_42594480_-intronic
ADediting_1001379chr22_42594484_-intronic
ADediting_1001380chr22_42596798_-intronic
ADediting_1001381chr22_42596801_-intronic
ADediting_1001382chr22_42596802_-intronic
ADediting_1001383chr22_42596815_-intronic
ADediting_1001384chr22_42597917_-intronic
ADediting_1001385chr22_42597918_-intronic
ADediting_1001386chr22_42597957_-intronic
ADediting_1001387chr22_42597958_-intronic
ADediting_1001388chr22_42597961_-intronic
ADediting_1001389chr22_42597982_-intronic
ADediting_1001390chr22_42598015_-intronic
ADediting_1001391chr22_42598020_-intronic
ADediting_1001392chr22_42598161_-intronic
ADediting_1001393chr22_42598221_-intronic
ADediting_1001394chr22_42598227_-intronic
ADediting_1001395chr22_42598351_-intronic
ADediting_1001396chr22_42598389_-intronic
ADediting_1001397chr22_42598411_-intronic
ADediting_1001398chr22_42598432_-intronic
ADediting_1001399chr22_42598446_-intronic
ADediting_1001400chr22_42598448_-intronic
ADediting_1001401chr22_42598457_-intronic
ADediting_1001402chr22_42598484_-intronic
ADediting_1001403chr22_42598579_-intronic
ADediting_1001404chr22_42598650_-intronic
ADediting_1001405chr22_42598679_-intronic
ADediting_1001406chr22_42599339_-intronic
ADediting_1001407chr22_42599347_-intronic
ADediting_1001408chr22_42599360_-intronic
ADediting_1001409chr22_42599400_-intronic
ADediting_1001410chr22_42599401_-intronic
ADediting_1001411chr22_42599412_-intronic
ADediting_1001412chr22_42599421_-intronic
ADediting_1001413chr22_42599438_-intronic
ADediting_1001414chr22_42599460_-intronic
ADediting_1001415chr22_42599482_-intronic
ADediting_1001416chr22_42599492_-intronic
ADediting_1001417chr22_42599504_-intronic
ADediting_1001418chr22_42599514_-intronic
ADediting_1001419chr22_42599517_-intronic
ADediting_1001420chr22_42599521_-intronic
ADediting_1001421chr22_42599522_-intronic
ADediting_1001422chr22_42599547_-intronic
ADediting_1001423chr22_42599557_-intronic
ADediting_1001424chr22_42599565_-intronic
ADediting_1571219chr22_42586466_-intronic
ADediting_1571220chr22_42586476_-intronic
ADediting_1571221chr22_42588841_-intronic
ADediting_1571222chr22_42589209_-intronic
ADediting_1571223chr22_42590286_-intronic
ADediting_1571224chr22_42590321_-intronic
ADediting_1571225chr22_42590451_-intronic
ADediting_1571226chr22_42590465_-intronic
ADediting_1571227chr22_42590950_-intronic
ADediting_1571228chr22_42594080_-intronic
ADediting_1571229chr22_42594094_-intronic
ADediting_1571230chr22_42594097_-intronic
ADediting_1571231chr22_42594104_-intronic
ADediting_1642932chr22_42588807_-intronic
ADediting_1642933chr22_42588821_-intronic
ADediting_1642934chr22_42596774_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1001302chr22_42586180_-SINEAluName=AluJr4
ADediting_1001303chr22_42587008_-SINEAluName=FLAM_A
ADediting_1001304chr22_42587025_-SINEAluName=FLAM_A
ADediting_1001305chr22_42588266_-SINEAluName=AluY
ADediting_1001306chr22_42588379_-SINEAluName=AluY
ADediting_1001307chr22_42588701_-SINEAluName=AluSp
ADediting_1001308chr22_42588721_-SINEAluName=AluSp
ADediting_1001309chr22_42588725_-SINEAluName=AluSp
ADediting_1001310chr22_42588726_-SINEAluName=AluSp
ADediting_1001311chr22_42588740_-SINEAluName=AluSp
ADediting_1001312chr22_42588766_-SINEAluName=AluSp
ADediting_1001313chr22_42588767_-SINEAluName=AluSp
ADediting_1001314chr22_42588777_-SINEAluName=AluSp
ADediting_1001315chr22_42588789_-SINEAluName=AluSp
ADediting_1001316chr22_42588793_-SINEAluName=AluSp
ADediting_1001317chr22_42588798_-SINEAluName=AluSp
ADediting_1001318chr22_42588801_-SINEAluName=AluSp
ADediting_1001319chr22_42588810_-SINEAluName=AluSp
ADediting_1001320chr22_42588826_-SINEAluName=AluSp
ADediting_1001321chr22_42588832_-SINEAluName=AluSp
ADediting_1001322chr22_42589038_-SINEAluName=AluSz6
ADediting_1001323chr22_42589073_-SINEAluName=AluSz6
ADediting_1001324chr22_42589076_-SINEAluName=AluSz6
ADediting_1001325chr22_42589079_-SINEAluName=AluSz6
ADediting_1001326chr22_42589094_-SINEAluName=AluSz6
ADediting_1001327chr22_42589095_-SINEAluName=AluSz6
ADediting_1001328chr22_42589099_-SINEAluName=AluSz6
ADediting_1001329chr22_42589121_-SINEAluName=AluSz6
ADediting_1001330chr22_42589126_-SINEAluName=AluSz6
ADediting_1001331chr22_42589167_-SINEAluName=AluSz6
ADediting_1001332chr22_42589180_-SINEAluName=AluSz6
ADediting_1001333chr22_42589186_-SINEAluName=AluSz6
ADediting_1001334chr22_42589199_-SINEAluName=AluSz6
ADediting_1001335chr22_42589700_-SINEAluName=AluSx1
ADediting_1001336chr22_42589722_-SINEAluName=AluSx1
ADediting_1001337chr22_42589744_-SINEAluName=AluSx1
ADediting_1001338chr22_42589757_-SINEAluName=AluSx1
ADediting_1001339chr22_42589758_-SINEAluName=AluSx1
ADediting_1001340chr22_42589761_-SINEAluName=AluSx1
ADediting_1001341chr22_42590277_-SINEAluName=AluJb
ADediting_1001342chr22_42590327_-SINEAluName=AluJb
ADediting_1001343chr22_42590355_-SINEAluName=AluJb
ADediting_1001344chr22_42590380_-SINEAluName=AluJb
ADediting_1001345chr22_42590396_-SINEAluName=AluJb
ADediting_1001346chr22_42590402_-SINEAluName=AluJb
ADediting_1001347chr22_42590430_-SINEAluName=AluJb
ADediting_1001348chr22_42590456_-SINEAluName=AluJb
ADediting_1001349chr22_42590820_-SINEAluName=AluSx
ADediting_1001350chr22_42590892_-SINEAluName=AluSx
ADediting_1001351chr22_42590952_-SINEAluName=AluSx
ADediting_1001352chr22_42590991_-SINEAluName=AluSx
ADediting_1001353chr22_42591011_-SINEAluName=AluSx
ADediting_1001354chr22_42593600_-SINEAluName=AluSx
ADediting_1001355chr22_42593614_-SINEAluName=AluSx
ADediting_1001356chr22_42593617_-SINEAluName=AluSx
ADediting_1001357chr22_42593621_-SINEAluName=AluSx
ADediting_1001358chr22_42593635_-SINEAluName=AluSx
ADediting_1001359chr22_42593643_-SINEAluName=AluSx
ADediting_1001360chr22_42593651_-SINEAluName=AluSx
ADediting_1001361chr22_42593687_-SINEAluName=AluSx
ADediting_1001362chr22_42593692_-SINEAluName=AluSx
ADediting_1001363chr22_42593698_-SINEAluName=AluSx
ADediting_1001364chr22_42593701_-SINEAluName=AluSx
ADediting_1001365chr22_42593715_-SINEAluName=AluSx
ADediting_1001366chr22_42593722_-SINEAluName=AluSx
ADediting_1001367chr22_42593746_-SINEAluName=AluSx
ADediting_1001368chr22_42593800_-SINEAluName=AluSx
ADediting_1001369chr22_42594005_-SINEAluName=AluSg
ADediting_1001370chr22_42594161_-SINEAluName=AluSg
ADediting_1001371chr22_42594178_-SINEAluName=AluSg
ADediting_1001372chr22_42594220_-SINEAluName=AluSg
ADediting_1001373chr22_42594306_-SINEAluName=AluSx1
ADediting_1001374chr22_42594331_-SINEAluName=AluSx1
ADediting_1001375chr22_42594345_-SINEAluName=AluSx1
ADediting_1001376chr22_42594389_-SINEAluName=AluSx1
ADediting_1001377chr22_42594399_-SINEAluName=AluSx1
ADediting_1001378chr22_42594480_-SINEAluName=AluSx1
ADediting_1001379chr22_42594484_-SINEAluName=AluSx1
ADediting_1001380chr22_42596798_-SINEAluName=AluJr4
ADediting_1001381chr22_42596801_-SINEAluName=AluJr4
ADediting_1001382chr22_42596802_-SINEAluName=AluJr4
ADediting_1001383chr22_42596815_-SINEAluName=AluJr4
ADediting_1001384chr22_42597917_-SINEAluName=AluSx
ADediting_1001385chr22_42597918_-SINEAluName=AluSx
ADediting_1001386chr22_42597957_-SINEAluName=AluSx
ADediting_1001387chr22_42597958_-SINEAluName=AluSx
ADediting_1001388chr22_42597961_-SINEAluName=AluSx
ADediting_1001389chr22_42597982_-SINEAluName=AluSx
ADediting_1001390chr22_42598015_-SINEAluName=AluSx
ADediting_1001391chr22_42598020_-SINEAluName=AluSx
ADediting_1001392chr22_42598161_-SINEAluName=AluY
ADediting_1001393chr22_42598221_-SINEAluName=AluY
ADediting_1001394chr22_42598227_-SINEAluName=AluY
ADediting_1001395chr22_42598351_-SINEAluName=AluY
ADediting_1001396chr22_42598389_-SINEAluName=AluY
ADediting_1001397chr22_42598411_-SINEAluName=AluY
ADediting_1001398chr22_42598432_-SINEAluName=AluY
ADediting_1001399chr22_42598446_-SINEAluName=AluY
ADediting_1001400chr22_42598448_-SINEAluName=AluY
ADediting_1001401chr22_42598457_-SINEAluName=AluY
ADediting_1001402chr22_42598484_-SINEAluName=AluY
ADediting_1001403chr22_42598579_-SINEAluName=AluY
ADediting_1001404chr22_42598650_-SINEAluName=AluY
ADediting_1001405chr22_42598679_-SINEAluName=AluY
ADediting_1001406chr22_42599339_-SINEAluName=AluSq2
ADediting_1001407chr22_42599347_-SINEAluName=AluSq2
ADediting_1001408chr22_42599360_-SINEAluName=AluSq2
ADediting_1001409chr22_42599400_-SINEAluName=AluSq2
ADediting_1001410chr22_42599401_-SINEAluName=AluSq2
ADediting_1001411chr22_42599412_-SINEAluName=AluSq2
ADediting_1001412chr22_42599421_-SINEAluName=AluSq2
ADediting_1001413chr22_42599438_-SINEAluName=AluSq2
ADediting_1001414chr22_42599460_-SINEAluName=AluSq2
ADediting_1001415chr22_42599482_-SINEAluName=AluSq2
ADediting_1001416chr22_42599492_-SINEAluName=AluSq2
ADediting_1001417chr22_42599504_-SINEAluName=AluSq2
ADediting_1001418chr22_42599514_-SINEAluName=AluSq2
ADediting_1001419chr22_42599517_-SINEAluName=AluSq2
ADediting_1001420chr22_42599521_-SINEAluName=AluSq2
ADediting_1001421chr22_42599522_-SINEAluName=AluSq2
ADediting_1001422chr22_42599547_-SINEAluName=AluSq2
ADediting_1001423chr22_42599557_-SINEAluName=AluSq2
ADediting_1001424chr22_42599565_-SINEAluName=AluSq2
ADediting_1571219chr22_42586466_-SINEAluName=AluJb
ADediting_1571220chr22_42586476_-SINEAluName=AluJb
ADediting_1571221chr22_42588841_-SINEAluName=AluSp
ADediting_1571222chr22_42589209_-SINEAluName=AluSz6
ADediting_1571223chr22_42590286_-SINEAluName=AluJb
ADediting_1571224chr22_42590321_-SINEAluName=AluJb
ADediting_1571225chr22_42590451_-SINEAluName=AluJb
ADediting_1571226chr22_42590465_-SINEAluName=AluJb
ADediting_1571227chr22_42590950_-SINEAluName=AluSx
ADediting_1571228chr22_42594080_-SINEAluName=AluSg
ADediting_1571229chr22_42594094_-SINEAluName=AluSg
ADediting_1571230chr22_42594097_-SINEAluName=AluSg
ADediting_1571231chr22_42594104_-SINEAluName=AluSg
ADediting_1642932chr22_42588807_-SINEAluName=AluSp
ADediting_1642933chr22_42588821_-SINEAluName=AluSp
ADediting_1642934chr22_42596774_-SINEAluName=AluJr4

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RNA A-to-I editing events in the alternative splicing sites for POLDIP3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for POLDIP3

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for POLDIP3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for POLDIP3


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1535951chr14_100874558_+ENSG00000100227.18ENST00000252115.10POLDIP3-201hsa-miR-337-3pchr2242584828425848347mer-m84258482742584847150-13.03
ADediting_1535951chr14_100874558_+ENSG00000100227.18ENST00000348657.6POLDIP3-203hsa-miR-337-3pchr2242584828425848347mer-m84258482742584847150-13.03
ADediting_1535951chr14_100874558_+ENSG00000100227.18ENST00000451060.6POLDIP3-205hsa-miR-337-3pchr2242584828425848347mer-m84258482742584847150-13.03
ADediting_1535951chr14_100874558_+ENSG00000100227.18ENST00000617178.4POLDIP3-209hsa-miR-337-3pchr2242584828425848347mer-m84258482742584847150-13.03
ADediting_843620chr2_207754818_+ENSG00000100227.18ENST00000252115.10POLDIP3-201hsa-miR-4775chr2242584488425844947mer-m84258448742584508140-10.13
ADediting_843620chr2_207754818_+ENSG00000100227.18ENST00000348657.6POLDIP3-203hsa-miR-4775chr2242584488425844947mer-m84258448742584508140-10.13
ADediting_843620chr2_207754818_+ENSG00000100227.18ENST00000451060.6POLDIP3-205hsa-miR-4775chr2242584488425844947mer-m84258448742584508140-10.13
ADediting_843620chr2_207754818_+ENSG00000100227.18ENST00000617178.4POLDIP3-209hsa-miR-4775chr2242584488425844947mer-m84258448742584508140-10.13

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000252115.10POLDIP3-201hsa-miR-5688chr2242584769425847757mer-m84258476842584789145-11.53
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000252115.10POLDIP3-201hsa-miR-5688chr2242584865425848717mer-m84258486442584887149-10.63
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000348657.6POLDIP3-203hsa-miR-5688chr2242584769425847757mer-m84258476842584789145-11.53
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000348657.6POLDIP3-203hsa-miR-5688chr2242584865425848717mer-m84258486442584887149-10.63
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000451060.6POLDIP3-205hsa-miR-5688chr2242584769425847757mer-m84258476842584789145-11.53
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000451060.6POLDIP3-205hsa-miR-5688chr2242584865425848717mer-m84258486442584887149-10.63
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000617178.4POLDIP3-209hsa-miR-5688chr2242584769425847757mer-m84258476842584789145-11.53
ADediting_1097295chr3_85385762_+ENSG00000100227.18ENST00000617178.4POLDIP3-209hsa-miR-5688chr2242584865425848717mer-m84258486442584887149-10.63
ADediting_1337757chr7_5495852_-ENSG00000100227.18ENST00000252115.10POLDIP3-201hsa-miR-589-3pchr2242585619425856257mer-m84258561842585649152-22.34
ADediting_1337757chr7_5495852_-ENSG00000100227.18ENST00000348657.6POLDIP3-203hsa-miR-589-3pchr2242585619425856257mer-m84258561842585649152-22.34
ADediting_1337757chr7_5495852_-ENSG00000100227.18ENST00000451060.6POLDIP3-205hsa-miR-589-3pchr2242585619425856257mer-m84258561842585649152-22.34
ADediting_1337758chr7_5495892_-ENSG00000100227.18ENST00000252115.10POLDIP3-201hsa-miR-589-5pchr2242585001425850088mer-1a4258500142585022150-18.08
ADediting_1337758chr7_5495892_-ENSG00000100227.18ENST00000339677.10POLDIP3-202hsa-miR-589-5pchr2242585001425850088mer-1a4258500142585022150-18.08
ADediting_1337758chr7_5495892_-ENSG00000100227.18ENST00000348657.6POLDIP3-203hsa-miR-589-5pchr2242585001425850088mer-1a4258500142585022150-18.08
ADediting_1337758chr7_5495892_-ENSG00000100227.18ENST00000451060.6POLDIP3-205hsa-miR-589-5pchr2242585001425850088mer-1a4258500142585022150-18.08
ADediting_1643790chr3_121049689_+ENSG00000100227.18ENST00000252115.10POLDIP3-201hsa-miR-5682chr2242583955425839617mer-m84258395442583977146-18.93
ADediting_1643790chr3_121049689_+ENSG00000100227.18ENST00000348657.6POLDIP3-203hsa-miR-5682chr2242583955425839617mer-m84258395442583977146-18.93
ADediting_1643790chr3_121049689_+ENSG00000100227.18ENST00000451060.6POLDIP3-205hsa-miR-5682chr2242583955425839617mer-m84258395442583977146-18.93
ADediting_1643790chr3_121049689_+ENSG00000100227.18ENST00000617178.4POLDIP3-209hsa-miR-5682chr2242583955425839617mer-m84258395442583977146-18.93

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for POLDIP3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for POLDIP3

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_1001303chr22_42587008_-0.01279753711611970.2028343212734661.1098584704542e-050.3503098400963050.004695485441882730.229668370825145
DLPFCADediting_1001381chr22_42596801_-0.9584666695015710.002969813413533720.0653678571493166-0.1047952563652982.04886053680286e-120.385367998472524
DLPFCADediting_1001392chr22_42598161_-0.0401535389481865-0.1166283010134320.000344155359763442-0.2020220436203467.06811379474201e-090.321346475350361
DLPFCADediting_1001396chr22_42598389_-0.0164041862056461-0.1362136982072748.56642896367008e-05-0.2212174679002884.31556432060897e-090.32566628575769
DLPFCADediting_1001397chr22_42598411_-0.0415662940403956-0.1158194366992490.00238688212223885-0.1719168006188221.71196509295944e-090.333583884648032
DLPFCADediting_1001399chr22_42598446_-0.9548418064613210.003229271634531480.332339494257201-0.05524002669473111.46672543994737e-100.35359755404937
DLPFCADediting_1001404chr22_42598650_-0.04655452813336480.1131370331309740.650177536361184-0.02585810622249421.93313576766135e-210.504711153847392
DLPFCADediting_1001413chr22_42599438_-0.625471319078062-0.02782988955912510.0167127355748751-0.135829664104076.28896350925529e-130.393576845363265
DLPFCADediting_1001414chr22_42599460_-0.7952979961019980.01479399569089790.0889171760114041-0.09678215977086379.66478304704985e-180.46130502775095
DLPFCADediting_1001415chr22_42599482_-0.0783599214887322-0.1001304297256690.000881269002136948-0.1879723709806257.71080082010021e-090.320577353710431
DLPFCADediting_1001424chr22_42599565_-0.9155832584915510.006044694686427720.276731352244893-0.06196766845165677.45790417525794e-090.320872322264611

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC5.25084412452313e-240.5315539265096285.6268192928701e-120.3781600785662482.48100418696382e-480.707386896383272
AC2.91887703584543e-540.7884481099405692.17124118412051e-280.6240511070309412.0798828935646e-250.595753157673187
PCC5.5878709392124e-090.4060964392512949.94016592815871e-090.39992159128390.000149365805048350.271014267854275
CER1.48546521884264e-290.7605575272765212.25637995745992e-380.8241760535594443.56016118949429e-080.431396798839583
TCX9.49839808527742e-110.497371764991520.390771747223750.0705762283501782.3871674661883e-230.699440099089077
FP3.40555994772533e-220.6435403737277757.19009207169574e-100.4410579971474851.8859632924405e-210.634610133992294
IFG0.0001736872944550060.6819630644260494.38674938389044e-050.723393490050820.00782387746748840.5191939680902
PG0.002024504536973150.2249304763847250.06132184333361840.1374752757102676.94461291376876e-150.530365777630737
STG5.09380785158549e-050.4270624500088350.02831154077404360.2393663300589090.0006381692899746990.365110744292787

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Relation with AD stages for POLDIP3

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER2.78702903096174e-070.470428258983134
TCX3.2446383541186e-130.633243821514473

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RelatedDrugs for POLDIP3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POLDIP3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource