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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RPAIN |
 Gene summary |
| Gene information | Gene symbol | RPAIN | Gene ID | 84268 |
| Gene name | RPA interacting protein | |
| Synonyms | HRIP|RIP | |
| Cytomap | 17p13.2 | |
| Type of gene | protein-coding | |
| Description | RPA-interacting proteinRAP interaction proteinnuclear transporter | |
| Modification date | 20200320 | |
| UniProtAcc | Q86UA6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RPAIN | GO:0006606 | protein import into nucleus | 16135809 |
Top |
RNA A-to-I events for RPAIN |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_639744(5423233, +), ADediting_639745(5423254, +), ADediting_639746(5423255, +), ADediting_639747(5423260, +), ADediting_639748(5423269, +), ADediting_639749(5423271, +), ADediting_639750(5423277, +), ADediting_639751(5423281, +), ADediting_639752(5423284, +), ADediting_639753(5423295, +), ADediting_639754(5423305, +), ADediting_639755(5423306, +), ADediting_639756(5423314, +), ADediting_639757(5423320, +), ADediting_639758(5423321, +), ADediting_639759(5423323, +), ADediting_639760(5423325, +), ADediting_639761(5423326, +), ADediting_639762(5423328, +), ADediting_639763(5423329, +), ADediting_639764(5423356, +), ADediting_639765(5423357, +), ADediting_639766(5423358, +), ADediting_639767(5423359, +), ADediting_639768(5423360, +), ADediting_639769(5423361, +), ADediting_639770(5423362, +), ADediting_639771(5423363, +), ADediting_639772(5423364, +), ADediting_639773(5423365, +), ADediting_639774(5423366, +), ADediting_639775(5423367, +), ADediting_639776(5423371, +), ADediting_639777(5423384, +), ADediting_639778(5423411, +), ADediting_639779(5423414, +), ADediting_639780(5423420, +), ADediting_639781(5423424, +), ADediting_639782(5423433, +), ADediting_639783(5423438, +), ADediting_639784(5423439, +), ADediting_639785(5423443, +), ADediting_639786(5423444, +), ADediting_639787(5423446, +), ADediting_639788(5423452, +), ADediting_639789(5423457, +), ADediting_639790(5423463, +), ADediting_639791(5423469, +), ADediting_639792(5423470, +), ADediting_639793(5423781, +), ADediting_639794(5423783, +), ADediting_639795(5423804, +), ADediting_639796(5423832, +), ADediting_639797(5423852, +), ADediting_639798(5423853, +), ADediting_639799(5423857, +), ADediting_639800(5423865, +), ADediting_639801(5423905, +), ADediting_639802(5424081, +), ADediting_639803(5424130, +), ADediting_639804(5424153, +), ADediting_639805(5424172, +), ADediting_639806(5424178, +), ADediting_639807(5424186, +), ADediting_639808(5424227, +), ADediting_639809(5424228, +), ADediting_639810(5424240, +), ADediting_639811(5424245, +), ADediting_639812(5424254, +), ADediting_639813(5424255, +), ADediting_639814(5424314, +), ADediting_639815(5424316, +), ADediting_639816(5424328, +), ADediting_639817(5424331, +), ADediting_639818(5424351, +), ADediting_639819(5424366, +), ADediting_639820(5424367, +), ADediting_639821(5424370, +), ADediting_639822(5424378, +), ADediting_639823(5424383, +), ADediting_639824(5424392, +), ADediting_639825(5424393, +), ADediting_639826(5424405, +), ADediting_1547593(5424011, +), ADediting_1547594(5424091, +), ADediting_1547595(5424262, +), |
Top |
RNA editing positional annotations for RPAIN using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_639744 | chr17_5423233_+ | intronic |
| ADediting_639745 | chr17_5423254_+ | intronic |
| ADediting_639746 | chr17_5423255_+ | intronic |
| ADediting_639747 | chr17_5423260_+ | intronic |
| ADediting_639748 | chr17_5423269_+ | intronic |
| ADediting_639749 | chr17_5423271_+ | intronic |
| ADediting_639750 | chr17_5423277_+ | intronic |
| ADediting_639751 | chr17_5423281_+ | intronic |
| ADediting_639752 | chr17_5423284_+ | intronic |
| ADediting_639753 | chr17_5423295_+ | intronic |
| ADediting_639754 | chr17_5423305_+ | intronic |
| ADediting_639755 | chr17_5423306_+ | intronic |
| ADediting_639756 | chr17_5423314_+ | intronic |
| ADediting_639757 | chr17_5423320_+ | intronic |
| ADediting_639758 | chr17_5423321_+ | intronic |
| ADediting_639759 | chr17_5423323_+ | intronic |
| ADediting_639760 | chr17_5423325_+ | intronic |
| ADediting_639761 | chr17_5423326_+ | intronic |
| ADediting_639762 | chr17_5423328_+ | intronic |
| ADediting_639763 | chr17_5423329_+ | intronic |
| ADediting_639764 | chr17_5423356_+ | intronic |
| ADediting_639765 | chr17_5423357_+ | intronic |
| ADediting_639766 | chr17_5423358_+ | intronic |
| ADediting_639767 | chr17_5423359_+ | intronic |
| ADediting_639768 | chr17_5423360_+ | intronic |
| ADediting_639769 | chr17_5423361_+ | intronic |
| ADediting_639770 | chr17_5423362_+ | intronic |
| ADediting_639771 | chr17_5423363_+ | intronic |
| ADediting_639772 | chr17_5423364_+ | intronic |
| ADediting_639773 | chr17_5423365_+ | intronic |
| ADediting_639774 | chr17_5423366_+ | intronic |
| ADediting_639775 | chr17_5423367_+ | intronic |
| ADediting_639776 | chr17_5423371_+ | intronic |
| ADediting_639777 | chr17_5423384_+ | intronic |
| ADediting_639778 | chr17_5423411_+ | intronic |
| ADediting_639779 | chr17_5423414_+ | intronic |
| ADediting_639780 | chr17_5423420_+ | intronic |
| ADediting_639781 | chr17_5423424_+ | intronic |
| ADediting_639782 | chr17_5423433_+ | intronic |
| ADediting_639783 | chr17_5423438_+ | intronic |
| ADediting_639784 | chr17_5423439_+ | intronic |
| ADediting_639785 | chr17_5423443_+ | intronic |
| ADediting_639786 | chr17_5423444_+ | intronic |
| ADediting_639787 | chr17_5423446_+ | intronic |
| ADediting_639788 | chr17_5423452_+ | intronic |
| ADediting_639789 | chr17_5423457_+ | intronic |
| ADediting_639790 | chr17_5423463_+ | intronic |
| ADediting_639791 | chr17_5423469_+ | intronic |
| ADediting_639792 | chr17_5423470_+ | intronic |
| ADediting_639793 | chr17_5423781_+ | intronic |
| ADediting_639794 | chr17_5423783_+ | intronic |
| ADediting_639795 | chr17_5423804_+ | intronic |
| ADediting_639796 | chr17_5423832_+ | intronic |
| ADediting_639797 | chr17_5423852_+ | intronic |
| ADediting_639798 | chr17_5423853_+ | intronic |
| ADediting_639799 | chr17_5423857_+ | intronic |
| ADediting_639800 | chr17_5423865_+ | intronic |
| ADediting_639801 | chr17_5423905_+ | intronic |
| ADediting_639802 | chr17_5424081_+ | intronic |
| ADediting_639803 | chr17_5424130_+ | intronic |
| ADediting_639804 | chr17_5424153_+ | intronic |
| ADediting_639805 | chr17_5424172_+ | intronic |
| ADediting_639806 | chr17_5424178_+ | intronic |
| ADediting_639807 | chr17_5424186_+ | intronic |
| ADediting_639808 | chr17_5424227_+ | intronic |
| ADediting_639809 | chr17_5424228_+ | intronic |
| ADediting_639810 | chr17_5424240_+ | intronic |
| ADediting_639811 | chr17_5424245_+ | intronic |
| ADediting_639812 | chr17_5424254_+ | intronic |
| ADediting_639813 | chr17_5424255_+ | intronic |
| ADediting_639814 | chr17_5424314_+ | intronic |
| ADediting_639815 | chr17_5424316_+ | intronic |
| ADediting_639816 | chr17_5424328_+ | intronic |
| ADediting_639817 | chr17_5424331_+ | intronic |
| ADediting_639818 | chr17_5424351_+ | intronic |
| ADediting_639819 | chr17_5424366_+ | intronic |
| ADediting_639820 | chr17_5424367_+ | intronic |
| ADediting_639821 | chr17_5424370_+ | intronic |
| ADediting_639822 | chr17_5424378_+ | intronic |
| ADediting_639823 | chr17_5424383_+ | intronic |
| ADediting_639824 | chr17_5424392_+ | intronic |
| ADediting_639825 | chr17_5424393_+ | intronic |
| ADediting_639826 | chr17_5424405_+ | intronic |
| ADediting_1547593 | chr17_5424011_+ | intronic |
| ADediting_1547594 | chr17_5424091_+ | intronic |
| ADediting_1547595 | chr17_5424262_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_639744 | chr17_5423233_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639745 | chr17_5423254_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639746 | chr17_5423255_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639747 | chr17_5423260_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639748 | chr17_5423269_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639749 | chr17_5423271_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639750 | chr17_5423277_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639751 | chr17_5423281_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639752 | chr17_5423284_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639753 | chr17_5423295_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639754 | chr17_5423305_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639755 | chr17_5423306_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639756 | chr17_5423314_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639757 | chr17_5423320_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639758 | chr17_5423321_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639759 | chr17_5423323_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639760 | chr17_5423325_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639761 | chr17_5423326_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639762 | chr17_5423328_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639763 | chr17_5423329_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639764 | chr17_5423356_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639765 | chr17_5423357_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639766 | chr17_5423358_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639767 | chr17_5423359_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639768 | chr17_5423360_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639769 | chr17_5423361_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639770 | chr17_5423362_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639771 | chr17_5423363_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639772 | chr17_5423364_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639773 | chr17_5423365_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639774 | chr17_5423366_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639775 | chr17_5423367_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639776 | chr17_5423371_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639777 | chr17_5423384_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639778 | chr17_5423411_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639779 | chr17_5423414_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639780 | chr17_5423420_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639781 | chr17_5423424_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639782 | chr17_5423433_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639783 | chr17_5423438_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639784 | chr17_5423439_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639785 | chr17_5423443_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639786 | chr17_5423444_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639787 | chr17_5423446_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639788 | chr17_5423452_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639789 | chr17_5423457_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639790 | chr17_5423463_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639791 | chr17_5423469_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639792 | chr17_5423470_+ | SINE | Alu | Name=AluJr4 |
| ADediting_639793 | chr17_5423781_+ | SINE | Alu | Name=AluJb |
| ADediting_639794 | chr17_5423783_+ | SINE | Alu | Name=AluJb |
| ADediting_639795 | chr17_5423804_+ | SINE | Alu | Name=AluJb |
| ADediting_639796 | chr17_5423832_+ | SINE | Alu | Name=AluJb |
| ADediting_639797 | chr17_5423852_+ | SINE | Alu | Name=AluJb |
| ADediting_639798 | chr17_5423853_+ | SINE | Alu | Name=AluJb |
| ADediting_639799 | chr17_5423857_+ | SINE | Alu | Name=AluJb |
| ADediting_639800 | chr17_5423865_+ | SINE | Alu | Name=AluJb |
| ADediting_639801 | chr17_5423905_+ | SINE | Alu | Name=AluJb |
| ADediting_639802 | chr17_5424081_+ | SINE | Alu | Name=AluJr |
| ADediting_639803 | chr17_5424130_+ | SINE | Alu | Name=AluJr |
| ADediting_639804 | chr17_5424153_+ | SINE | Alu | Name=AluJr |
| ADediting_639805 | chr17_5424172_+ | SINE | Alu | Name=AluJr |
| ADediting_639806 | chr17_5424178_+ | SINE | Alu | Name=AluJr |
| ADediting_639807 | chr17_5424186_+ | SINE | Alu | Name=AluJr |
| ADediting_639808 | chr17_5424227_+ | SINE | Alu | Name=AluJr |
| ADediting_639809 | chr17_5424228_+ | SINE | Alu | Name=AluJr |
| ADediting_639810 | chr17_5424240_+ | SINE | Alu | Name=AluJr |
| ADediting_639811 | chr17_5424245_+ | SINE | Alu | Name=AluJr |
| ADediting_639812 | chr17_5424254_+ | SINE | Alu | Name=AluJr |
| ADediting_639813 | chr17_5424255_+ | SINE | Alu | Name=AluJr |
| ADediting_639814 | chr17_5424314_+ | SINE | Alu | Name=AluJb |
| ADediting_639815 | chr17_5424316_+ | SINE | Alu | Name=AluJb |
| ADediting_639816 | chr17_5424328_+ | SINE | Alu | Name=AluJb |
| ADediting_639817 | chr17_5424331_+ | SINE | Alu | Name=AluJb |
| ADediting_639818 | chr17_5424351_+ | SINE | Alu | Name=AluJb |
| ADediting_639819 | chr17_5424366_+ | SINE | Alu | Name=AluJb |
| ADediting_639820 | chr17_5424367_+ | SINE | Alu | Name=AluJb |
| ADediting_639821 | chr17_5424370_+ | SINE | Alu | Name=AluJb |
| ADediting_639822 | chr17_5424378_+ | SINE | Alu | Name=AluJb |
| ADediting_639823 | chr17_5424383_+ | SINE | Alu | Name=AluJb |
| ADediting_639824 | chr17_5424392_+ | SINE | Alu | Name=AluJb |
| ADediting_639825 | chr17_5424393_+ | SINE | Alu | Name=AluJb |
| ADediting_639826 | chr17_5424405_+ | SINE | Alu | Name=AluJb |
| ADediting_1547593 | chr17_5424011_+ | SINE | Alu | Name=AluJr |
| ADediting_1547594 | chr17_5424091_+ | SINE | Alu | Name=AluJr |
| ADediting_1547595 | chr17_5424262_+ | SINE | Alu | Name=AluJr |
Top |
RNA A-to-I editing events in the alternative splicing sites for RPAIN |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for RPAIN |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for RPAIN |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for RPAIN |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000129197.14 | ENST00000405578.8 | RPAIN-204 | hsa-miR-5688 | chr17 | 5428593 | 5428599 | 7mer-m8 | 5428579 | 5428600 | 140 | -12.17 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for RPAIN |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for RPAIN |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_639745 | chr17_5423254_+ | 8.39199356094435e-11 | 0.498611232220733 | 3.94406613992591e-07 | 0.400021146093594 | 0.224473920966762 | 0.0997682002917004 |
| TCX | ADediting_639745 | chr17_5423254_+ | 1.41019403948378e-05 | 0.346402235110914 | 0.00393901026158324 | 0.234075181938645 | 0.984715017899388 | 0.00157744385601734 |
| CER | ADediting_639746 | chr17_5423255_+ | 1.85672384900303e-10 | 0.490575970945011 | 5.65442830093354e-09 | 0.453418754691232 | 0.165750035302348 | 0.113749500520312 |
| TCX | ADediting_639746 | chr17_5423255_+ | 2.71168521567963e-05 | 0.335460329443395 | 0.000278934875000373 | 0.292649301510251 | 0.0726230016104652 | -0.147009231791223 |
| CER | ADediting_639747 | chr17_5423260_+ | 1.6217336988794e-10 | 0.491960001903249 | 2.5447232657564e-08 | 0.435534169871392 | 0.535595258207959 | 0.0509744680912878 |
| CER | ADediting_639748 | chr17_5423269_+ | 5.84496418624639e-16 | 0.598741531721776 | 2.65157703044656e-09 | 0.462047448634799 | 0.0563274091144658 | 0.156176775799858 |
| CER | ADediting_639749 | chr17_5423271_+ | 4.11594599417043e-14 | 0.566583181580109 | 3.78265813915424e-10 | 0.483194096902652 | 0.684546070784273 | 0.0334420784004332 |
| CER | ADediting_639751 | chr17_5423281_+ | 2.8902960934307e-22 | 0.686902544587017 | 6.74590446687945e-14 | 0.562610428574897 | 0.0739698317524314 | 0.146329375250613 |
| TCX | ADediting_639751 | chr17_5423281_+ | 4.93600000588402e-05 | 0.325060396151855 | 0.00174440830959387 | 0.253544479156641 | 0.21255661445493 | 0.102370449708977 |
| CER | ADediting_639754 | chr17_5423305_+ | 2.59356306408017e-08 | 0.43530139929763 | 4.84084426307303e-06 | 0.36346108124782 | 0.197059332903484 | 0.105915526123111 |
| CER | ADediting_639758 | chr17_5423321_+ | 3.42956315107145e-05 | 0.331427121250696 | 0.00614097290132054 | 0.222777740907782 | 0.274958858136939 | -0.089708665154225 |
| CER | ADediting_639760 | chr17_5423325_+ | 6.36530839658327e-13 | 0.543867457641281 | 3.97406284040455e-07 | 0.399917054787267 | 0.80758347601658 | 0.0200510771793303 |
| CER | ADediting_639761 | chr17_5423326_+ | 6.39178235301222e-15 | 0.581097440268503 | 1.13280505704643e-06 | 0.385172790513483 | 0.517575935682856 | -0.0532422980657193 |
| CER | ADediting_639762 | chr17_5423328_+ | 9.85380099331016e-16 | 0.594979703107839 | 2.7619423065737e-08 | 0.434529972593854 | 0.645999047839398 | -0.0378067860700842 |
| TCX | ADediting_639762 | chr17_5423328_+ | 0.00376374950893732 | 0.235204119491752 | 0.387635384630352 | 0.0710433727866284 | 0.000164657966538348 | 0.302917794693295 |
| CER | ADediting_639763 | chr17_5423329_+ | 6.44999669287936e-15 | 0.581028488872539 | 2.6424826975131e-07 | 0.405473395287664 | 0.66739172562526 | 0.035372266028375 |
| CER | ADediting_639777 | chr17_5423384_+ | 3.58607300503e-15 | 0.585459665377205 | 9.21871169563723e-08 | 0.4193637892544 | 0.678651777331042 | 0.0341031930178885 |
| CER | ADediting_639778 | chr17_5423411_+ | 6.66973111184232e-08 | 0.423509998593918 | 1.16012999463121e-05 | 0.349590953300309 | 0.47839235164662 | 0.0583192553200345 |
| CER | ADediting_639779 | chr17_5423414_+ | 9.93581361753551e-11 | 0.496919935241029 | 2.70806479873492e-06 | 0.372333466688156 | 0.515045549411813 | 0.0535639556895603 |
| TCX | ADediting_639779 | chr17_5423414_+ | 4.56090119504314e-05 | 0.326454379245249 | 0.00181591834311199 | 0.252618559011863 | 0.967334772119726 | 0.00337185204631142 |
| CER | ADediting_639781 | chr17_5423424_+ | 3.07342217441328e-16 | 0.603304793958728 | 2.75720626525141e-15 | 0.587422145587602 | 0.353780353201197 | 0.0762397391848098 |
| TCX | ADediting_639781 | chr17_5423424_+ | 1.99854909505619e-05 | 0.3406180856187 | 0.303644536955669 | 0.0845456377128445 | 0.00096053375172001 | 0.266918507402399 |
| CER | ADediting_639782 | chr17_5423433_+ | 7.11375684531252e-15 | 0.580282526283749 | 3.97542285957576e-12 | 0.527659076721049 | 0.328093969934343 | 0.080393316038725 |
| TCX | ADediting_639782 | chr17_5423433_+ | 0.00245160074492532 | 0.245592360065196 | 0.463889866711946 | -0.0602545274490128 | 1.3584137826878e-08 | 0.44312331564821 |
| CER | ADediting_639784 | chr17_5423439_+ | 3.62779499237229e-15 | 0.585372994627561 | 1.33514830849182e-13 | 0.557032411589082 | 0.53392890337245 | 0.05118255905138 |
| TCX | ADediting_639784 | chr17_5423439_+ | 0.000168248134005071 | 0.302505000298564 | 0.0972487559163064 | 0.135910858087411 | 0.137613727276275 | 0.12179528546547 |
| CER | ADediting_639785 | chr17_5423443_+ | 3.59145028062691e-09 | 0.45861913019719 | 1.02901583116482e-06 | 0.386555590900372 | 0.418322587856872 | -0.0665654259075024 |
| CER | ADediting_639786 | chr17_5423444_+ | 2.58282804937284e-15 | 0.587907906781142 | 1.21432300577215e-11 | 0.517339190546668 | 0.250524118111638 | 0.0944017926389291 |
| TCX | ADediting_639786 | chr17_5423444_+ | 0.00479715377871417 | 0.22912552784287 | 0.753298704506357 | 0.0258740466473989 | 1.31694594574834e-07 | 0.414729166382995 |
| CER | ADediting_639788 | chr17_5423452_+ | 1.89358438044138e-06 | 0.377670303912205 | 1.89526882976213e-05 | 0.34150568291368 | 0.862951159947981 | 0.0142124389860948 |
| CER | ADediting_639789 | chr17_5423457_+ | 5.98191229772491e-13 | 0.544402228878612 | 3.46120403222171e-11 | 0.50733307081031 | 0.667618870532432 | 0.0353465840179204 |
| TCX | ADediting_639789 | chr17_5423457_+ | 5.65961168439856e-07 | 0.395019767359168 | 0.000313819341002131 | 0.290300279055477 | 0.198881477246078 | 0.105488495190315 |
| DLPFC | ADediting_639794 | chr17_5423783_+ | 2.62699368236149e-10 | 0.348977273846848 | 2.12438934361267e-06 | 0.265507118345191 | 3.98730478595143e-09 | 0.32635270389221 |
| CER | ADediting_639794 | chr17_5423783_+ | 2.07199163132635e-11 | 0.51227545338664 | 0.000132401497905529 | 0.307056460199138 | 0.637340508866385 | -0.0388014102514808 |
| TCX | ADediting_639794 | chr17_5423783_+ | 4.62392573642969e-05 | 0.326212810696738 | 0.0768859993390238 | 0.144890976010121 | 0.0715223051307998 | 0.147572471562696 |
| DLPFC | ADediting_639796 | chr17_5423832_+ | 1.95034488234789e-09 | 0.332481128415775 | 3.22576977510361e-08 | 0.307606613178713 | 8.87792276686429e-09 | 0.319327120756903 |
| CER | ADediting_639796 | chr17_5423832_+ | 1.54700068423053e-11 | 0.515054865264267 | 3.00526216165739e-09 | 0.460637202822567 | 0.151395351771073 | 0.117713325834325 |
| DLPFC | ADediting_639797 | chr17_5423852_+ | 4.08181022697686e-09 | 0.326149635250082 | 1.26084379465236e-07 | 0.294638041201599 | 7.23022540378769e-06 | 0.251734259606851 |
| CER | ADediting_639797 | chr17_5423852_+ | 1.90569673738303e-06 | 0.377576013182654 | 3.06036301508846e-07 | 0.403485945685125 | 0.905824845377944 | 0.00974093990142399 |
| TCX | ADediting_639797 | chr17_5423852_+ | 4.72320228630659e-05 | 0.325838487934371 | 8.56297131701667e-08 | 0.420313972310657 | 0.142460462239337 | -0.120325753350003 |
| DLPFC | ADediting_639798 | chr17_5423853_+ | 1.13390199710555e-10 | 0.35561427031308 | 2.98374423025819e-09 | 0.328853822832876 | 1.89271011529582e-07 | 0.29064646877923 |
| CER | ADediting_639798 | chr17_5423853_+ | 1.41049670586024e-07 | 0.413829349969566 | 1.44973338578632e-07 | 0.413468854136428 | 0.602188134276603 | 0.0428996847794827 |
| TCX | ADediting_639798 | chr17_5423853_+ | 9.5727952058541e-07 | 0.387591315683222 | 0.000233456524686522 | 0.296159480655594 | 0.353014435275519 | 0.0763607860297593 |
| DLPFC | ADediting_639799 | chr17_5423857_+ | 3.83349448555482e-07 | 0.283562083628273 | 2.58795320359643e-08 | 0.309644348753409 | 0.127984307128822 | 0.0866367775989373 |
| DLPFC | ADediting_639800 | chr17_5423865_+ | 2.31078536941182e-11 | 0.367773723711384 | 3.89804354541454e-11 | 0.363832974059978 | 0.0001905439548256 | 0.210392972606339 |
| CER | ADediting_639800 | chr17_5423865_+ | 6.68954118276131e-16 | 0.597774111595809 | 9.52233782841579e-14 | 0.559806988809282 | 0.449555757411343 | 0.0622003867821631 |
| TCX | ADediting_639800 | chr17_5423865_+ | 2.14514432010514e-07 | 0.408274079137947 | 2.65521570850679e-05 | 0.335818987553351 | 0.0622252854268618 | 0.152634557135221 |
| DLPFC | ADediting_639802 | chr17_5424081_+ | 9.82090082190806e-10 | 0.338236355882231 | 3.58960356725984e-07 | 0.284230212425507 | 1.38472674157176e-06 | 0.270143114248032 |
| CER | ADediting_639802 | chr17_5424081_+ | 3.06191590003677e-08 | 0.433261296900324 | 1.04942624895149e-05 | 0.351215915018481 | 0.797085781722961 | 0.0211685296644019 |
| TCX | ADediting_639802 | chr17_5424081_+ | 2.09225535300498e-05 | 0.339849410948525 | 0.15976350338278 | 0.115370044375302 | 0.00118974758677593 | 0.262200638144239 |
| DLPFC | ADediting_639803 | chr17_5424130_+ | 1.68449749265913e-08 | 0.313572285194489 | 8.43936191222125e-08 | 0.298523822427086 | 6.2917610865373e-05 | 0.225257466675352 |
| CER | ADediting_639803 | chr17_5424130_+ | 1.6950970154982e-10 | 0.491508152006597 | 1.05618402059158e-08 | 0.446114510383632 | 0.0425053881253482 | 0.165867854432449 |
| TCX | ADediting_639803 | chr17_5424130_+ | 1.96167268644978e-06 | 0.377147530476379 | 0.0301294820646079 | 0.177127177015369 | 0.00570408549768065 | 0.224692242333502 |
| CER | ADediting_639805 | chr17_5424172_+ | 1.0466169389817e-06 | 0.386311991216688 | 0.0024607642476526 | 0.245503786693205 | 0.489259317159429 | 0.0568898678347864 |
| CER | ADediting_639806 | chr17_5424178_+ | 6.80311954775166e-09 | 0.451274554855697 | 3.40875605890928e-09 | 0.45921176852332 | 0.21799717288714 | 0.101169914275946 |
| CER | ADediting_639807 | chr17_5424186_+ | 1.38691467397928e-09 | 0.469246142966009 | 2.6425575748913e-07 | 0.405473012946503 | 0.905130851235784 | 0.00981305881440983 |
| CER | ADediting_639809 | chr17_5424228_+ | 0.000179644860559592 | 0.301246886367783 | 0.000658677829791196 | 0.275034449664235 | 0.0581784786101469 | 0.155033482028889 |
| CER | ADediting_639810 | chr17_5424240_+ | 1.69145931006739e-14 | 0.573602519404353 | 2.64535664970143e-13 | 0.551339539966251 | 0.400223080040923 | 0.0691819566348286 |
| DLPFC | ADediting_639814 | chr17_5424314_+ | 3.49747883031405e-08 | 0.306854679993223 | 8.97484527889181e-06 | 0.249219857567356 | 6.06222019850609e-08 | 0.301683443398665 |
| CER | ADediting_639814 | chr17_5424314_+ | 7.2084441725433e-10 | 0.47634987408815 | 0.000219454503308982 | 0.29736889081259 | 0.548908718009767 | 0.0493233044914081 |
| TCX | ADediting_639814 | chr17_5424314_+ | 7.92321316511893e-05 | 0.316568072518036 | 0.116396170278459 | 0.128739511144518 | 0.0139506975663785 | 0.200374227455854 |
| DLPFC | ADediting_639816 | chr17_5424328_+ | 4.18169962649198e-10 | 0.345237220304507 | 4.58686281698499e-06 | 0.256943231194048 | 2.9926386418062e-07 | 0.286069892178254 |
| CER | ADediting_639816 | chr17_5424328_+ | 4.54052169939244e-09 | 0.455943373521685 | 1.08312898438187e-05 | 0.350704701974881 | 0.734115649209591 | 0.0279612761386756 |
| TCX | ADediting_639816 | chr17_5424328_+ | 1.13780373618485e-05 | 0.349906512623534 | 0.000208228853977905 | 0.298391450490002 | 0.973057446284245 | -0.0027808858142695 |
| DLPFC | ADediting_639817 | chr17_5424331_+ | 2.01305585865206e-11 | 0.368804380574953 | 7.75740391720695e-11 | 0.358563101111897 | 0.000520561122884916 | 0.195957282653505 |
| CER | ADediting_639817 | chr17_5424331_+ | 9.71983617105252e-08 | 0.41868034592523 | 0.000455089959001725 | 0.282755480179271 | 0.4962152641741 | -0.0559838002322045 |
| TCX | ADediting_639817 | chr17_5424331_+ | 1.5861527492616e-07 | 0.412284297686563 | 0.000910373955490403 | 0.26808767578021 | 0.251334412996291 | 0.0942412392087592 |
| DLPFC | ADediting_639819 | chr17_5424366_+ | 9.17817728043057e-08 | 0.297716267612161 | 4.65840425471036e-10 | 0.344361573168151 | 0.999455232649253 | -3.89357187658534e-05 |
| DLPFC | ADediting_639820 | chr17_5424367_+ | 1.17915295736738e-08 | 0.316792057389348 | 8.36432022598779e-09 | 0.319856425091591 | 0.115488006624659 | 0.0895791240711038 |
| CER | ADediting_639820 | chr17_5424367_+ | 6.69563239255186e-10 | 0.477140856997178 | 9.60044027035484e-07 | 0.38755005173436 | 0.00303256335675535 | 0.240492831083744 |
| DLPFC | ADediting_639822 | chr17_5424378_+ | 1.20797849306663e-08 | 0.316575233703713 | 1.9226535970892e-09 | 0.332602305603171 | 0.0503853948577752 | 0.111236068691281 |
| CER | ADediting_639822 | chr17_5424378_+ | 4.3375015830168e-12 | 0.526865888358397 | 1.8235133902938e-07 | 0.410438375354135 | 0.0480576124194424 | 0.161698686479646 |
| TCX | ADediting_639823 | chr17_5424383_+ | 0.0173442302619011 | 0.194044327671674 | 5.86776510686877e-06 | 0.360463319007798 | 0.065067311199605 | -0.151025142214635 |
| DLPFC | ADediting_639824 | chr17_5424392_+ | 4.49890523146766e-08 | 0.30449987946132 | 3.93622719554189e-08 | 0.30575202476338 | 0.798249536792198 | -0.0145759653792375 |
| DLPFC | ADediting_639825 | chr17_5424393_+ | 2.30888452783581e-07 | 0.288670972893022 | 8.55634231826751e-09 | 0.319654943629261 | 0.96451403203074 | 0.00253709248441482 |
| CER | ADediting_639825 | chr17_5424393_+ | 4.2110243233179e-06 | 0.36561426861011 | 0.00201450619831559 | 0.250211045536537 | 0.32916802907521 | 0.0802155689155365 |
| DLPFC | ADediting_639826 | chr17_5424405_+ | 3.4192190134416e-08 | 0.307065307910839 | 4.8757884199549e-09 | 0.32460391983729 | 0.917195236718837 | -0.00592884951479694 |
| CER | ADediting_639826 | chr17_5424405_+ | 3.52540960006974e-16 | 0.60233683451687 | 3.32320326946474e-12 | 0.529283300565518 | 0.0839823567029874 | 0.141566063032327 |
| TCX | ADediting_639826 | chr17_5424405_+ | 0.000262751367234642 | 0.293833104262031 | 1.94052928334174e-09 | 0.46553607232958 | 0.0400855969859997 | -0.167828954819483 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.53991589782034e-52 | 0.728537430473277 | 6.69009841877767e-41 | 0.664762578881255 | 3.71007442689149e-19 | 0.478656101891323 |
| AC | 9.56165086128992e-84 | 0.883723662002512 | 4.69460568963534e-71 | 0.85020324384131 | 7.31915543341016e-10 | 0.376956194359114 |
| PCC | 2.87082440245114e-37 | 0.760361083572017 | 1.53678118162884e-41 | 0.787216043966714 | 0.0296112820540415 | 0.157446179578113 |
| CER | 5.67765123777962e-40 | 0.833540785451769 | 1.83735122085483e-29 | 0.759763615939641 | 0.0221621475913313 | 0.18669634657518 |
| TCX | 1.62859394674229e-37 | 0.818908977537772 | 1.48971923601084e-17 | 0.623858665253435 | 0.0409905046118502 | 0.167084247851933 |
| FP | 1.30023158347805e-23 | 0.659795000097395 | 2.39439616079298e-26 | 0.688531807662626 | 0.320726943047288 | 0.074848754871242 |
| IFG | 2.27723855084552e-06 | 0.792988906959677 | 0.000318783283205515 | 0.661325861191837 | 0.802766485017285 | -0.0526127036158256 |
| PG | 4.73930795388213e-38 | 0.771952410330258 | 3.09686309150996e-35 | 0.752680946514434 | 0.582695231148002 | -0.040544533739854 |
| STG | 4.89927736480504e-22 | 0.825119594844417 | 4.07319584181958e-19 | 0.790146553861814 | 0.431748306649925 | 0.0869217180702322 |
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Relation with AD stages for RPAIN |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_639782 | chr17_5423433_+ | 2.140658336806e-05 | 0.396638124274108 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for RPAIN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPAIN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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