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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for KIAA1109

check button Gene summary
Gene informationGene symbol

KIAA1109

Gene ID

84162

Gene nameKIAA1109
SynonymsALKKUCS|FSA|Tweek
Cytomap

4q27

Type of geneprotein-coding
Descriptiontransmembrane protein KIAA1109fragile site-associated protein
Modification date20200327
UniProtAcc

Q2LD37,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for KIAA1109

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1104723(122155355, +), ADediting_1104724(122155388, +), ADediting_1104725(122155404, +), ADediting_1104726(122155424, +), ADediting_1104727(122155428, +), ADediting_1104728(122155434, +), ADediting_1104729(122155442, +), ADediting_1104730(122155453, +), ADediting_1104731(122155479, +), ADediting_1104732(122155513, +), ADediting_1104733(122155521, +), ADediting_1104734(122155524, +), ADediting_1104735(122155586, +), ADediting_1104736(122155598, +), ADediting_1104737(122159316, +), ADediting_1104738(122159352, +), ADediting_1104739(122159369, +), ADediting_1104740(122159375, +), ADediting_1104741(122159384, +), ADediting_1104742(122161570, +), ADediting_1104743(122161672, +), ADediting_1104744(122161677, +), ADediting_1104745(122161687, +), ADediting_1104746(122170117, +), ADediting_1104747(122170130, +), ADediting_1104748(122170136, +), ADediting_1104749(122170159, +), ADediting_1104750(122170185, +), ADediting_1104751(122170186, +), ADediting_1104752(122170191, +), ADediting_1104753(122170212, +), ADediting_1104754(122170227, +), ADediting_1104755(122170255, +), ADediting_1104756(122170260, +), ADediting_1104757(122277122, +), ADediting_1104758(122277127, +), ADediting_1104759(122277194, +), ADediting_1104760(122277202, +), ADediting_1104761(122277220, +), ADediting_1104762(122277226, +), ADediting_1104763(122277235, +), ADediting_1104764(122277256, +), ADediting_1104765(122277267, +), ADediting_1104766(122278735, +), ADediting_1104767(122278736, +), ADediting_1104768(122278758, +), ADediting_1104769(122278761, +), ADediting_1104770(122278764, +), ADediting_1104771(122278789, +), ADediting_1104772(122282422, +), ADediting_1104773(122282492, +), ADediting_1104774(122282527, +), ADediting_1104775(122282531, +), ADediting_1104776(122283591, +), ADediting_1104777(122283607, +), ADediting_1104778(122283640, +), ADediting_1104779(122283744, +), ADediting_1104780(122283745, +), ADediting_1104781(122283772, +), ADediting_1104782(122283784, +), ADediting_1104783(122292097, +), ADediting_1576215(122278712, +), ADediting_1650006(122278861, +), ADediting_1650007(122282443, +), ADediting_1650008(122282495, +), ADediting_1650009(122282522, +), ADediting_1650010(122283535, +), ADediting_1650011(122283543, +), ADediting_1650012(122283598, +), ADediting_1650013(122283624, +), ADediting_1650014(122283673, +), ADediting_1650015(122288545, +),

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RNA editing positional annotations for KIAA1109 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1104723chr4_122155355_+intronic
ADediting_1104724chr4_122155388_+intronic
ADediting_1104725chr4_122155404_+intronic
ADediting_1104726chr4_122155424_+intronic
ADediting_1104727chr4_122155428_+intronic
ADediting_1104728chr4_122155434_+intronic
ADediting_1104729chr4_122155442_+intronic
ADediting_1104730chr4_122155453_+intronic
ADediting_1104731chr4_122155479_+intronic
ADediting_1104732chr4_122155513_+intronic
ADediting_1104733chr4_122155521_+intronic
ADediting_1104734chr4_122155524_+intronic
ADediting_1104735chr4_122155586_+intronic
ADediting_1104736chr4_122155598_+intronic
ADediting_1104737chr4_122159316_+intronic
ADediting_1104738chr4_122159352_+intronic
ADediting_1104739chr4_122159369_+intronic
ADediting_1104740chr4_122159375_+intronic
ADediting_1104741chr4_122159384_+intronic
ADediting_1104742chr4_122161570_+intronic
ADediting_1104743chr4_122161672_+intronic
ADediting_1104744chr4_122161677_+intronic
ADediting_1104745chr4_122161687_+intronic
ADediting_1104746chr4_122170117_+intronic
ADediting_1104747chr4_122170130_+intronic
ADediting_1104748chr4_122170136_+intronic
ADediting_1104749chr4_122170159_+intronic
ADediting_1104750chr4_122170185_+intronic
ADediting_1104751chr4_122170186_+intronic
ADediting_1104752chr4_122170191_+intronic
ADediting_1104753chr4_122170212_+intronic
ADediting_1104754chr4_122170227_+intronic
ADediting_1104755chr4_122170255_+intronic
ADediting_1104756chr4_122170260_+intronic
ADediting_1104757chr4_122277122_+intronic
ADediting_1104758chr4_122277127_+intronic
ADediting_1104759chr4_122277194_+intronic
ADediting_1104760chr4_122277202_+intronic
ADediting_1104761chr4_122277220_+intronic
ADediting_1104762chr4_122277226_+intronic
ADediting_1104763chr4_122277235_+intronic
ADediting_1104764chr4_122277256_+intronic
ADediting_1104765chr4_122277267_+intronic
ADediting_1104766chr4_122278735_+intronic
ADediting_1104767chr4_122278736_+intronic
ADediting_1104768chr4_122278758_+intronic
ADediting_1104769chr4_122278761_+intronic
ADediting_1104770chr4_122278764_+intronic
ADediting_1104771chr4_122278789_+intronic
ADediting_1104772chr4_122282422_+intronic
ADediting_1104773chr4_122282492_+intronic
ADediting_1104774chr4_122282527_+intronic
ADediting_1104775chr4_122282531_+intronic
ADediting_1104776chr4_122283591_+intronic
ADediting_1104777chr4_122283607_+intronic
ADediting_1104778chr4_122283640_+intronic
ADediting_1104779chr4_122283744_+intronic
ADediting_1104780chr4_122283745_+intronic
ADediting_1104781chr4_122283772_+intronic
ADediting_1104782chr4_122283784_+intronic
ADediting_1104783chr4_122292097_+intronic
ADediting_1576215chr4_122278712_+intronic
ADediting_1650006chr4_122278861_+intronic
ADediting_1650007chr4_122282443_+intronic
ADediting_1650008chr4_122282495_+intronic
ADediting_1650009chr4_122282522_+intronic
ADediting_1650010chr4_122283535_+intronic
ADediting_1650011chr4_122283543_+intronic
ADediting_1650012chr4_122283598_+intronic
ADediting_1650013chr4_122283624_+intronic
ADediting_1650014chr4_122283673_+intronic
ADediting_1650015chr4_122288545_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1104723chr4_122155355_+SINEAluName=AluSz
ADediting_1104724chr4_122155388_+SINEAluName=AluSz
ADediting_1104725chr4_122155404_+SINEAluName=AluSz
ADediting_1104726chr4_122155424_+SINEAluName=AluSz
ADediting_1104727chr4_122155428_+SINEAluName=AluSz
ADediting_1104728chr4_122155434_+SINEAluName=AluSz
ADediting_1104729chr4_122155442_+SINEAluName=AluSz
ADediting_1104730chr4_122155453_+SINEAluName=AluSz
ADediting_1104731chr4_122155479_+SINEAluName=AluSz
ADediting_1104732chr4_122155513_+SINEAluName=AluSz
ADediting_1104733chr4_122155521_+SINEAluName=AluSz
ADediting_1104734chr4_122155524_+SINEAluName=AluSz
ADediting_1104735chr4_122155586_+SINEAluName=AluSz
ADediting_1104736chr4_122155598_+SINEAluName=AluSz
ADediting_1104737chr4_122159316_+SINEAluName=AluSc8
ADediting_1104738chr4_122159352_+SINEAluName=AluSc8
ADediting_1104739chr4_122159369_+SINEAluName=AluSc8
ADediting_1104740chr4_122159375_+SINEAluName=AluSc8
ADediting_1104741chr4_122159384_+SINEAluName=AluSc8
ADediting_1104742chr4_122161570_+SINEAluName=AluJb
ADediting_1104743chr4_122161672_+SINEAluName=AluJb
ADediting_1104744chr4_122161677_+SINEAluName=AluJb
ADediting_1104745chr4_122161687_+SINEAluName=AluJb
ADediting_1104746chr4_122170117_+SINEAluName=AluSp
ADediting_1104747chr4_122170130_+SINEAluName=AluSp
ADediting_1104748chr4_122170136_+SINEAluName=AluSp
ADediting_1104749chr4_122170159_+SINEAluName=AluSp
ADediting_1104750chr4_122170185_+SINEAluName=AluSp
ADediting_1104751chr4_122170186_+SINEAluName=AluSp
ADediting_1104752chr4_122170191_+SINEAluName=AluSp
ADediting_1104753chr4_122170212_+SINEAluName=AluSp
ADediting_1104754chr4_122170227_+SINEAluName=AluSp
ADediting_1104755chr4_122170255_+SINEAluName=AluSp
ADediting_1104756chr4_122170260_+SINEAluName=AluSp
ADediting_1104757chr4_122277122_+SINEAluName=AluJr
ADediting_1104758chr4_122277127_+SINEAluName=AluJr
ADediting_1104759chr4_122277194_+SINEAluName=AluJr
ADediting_1104760chr4_122277202_+SINEAluName=AluJr
ADediting_1104761chr4_122277220_+SINEAluName=AluJr
ADediting_1104762chr4_122277226_+SINEAluName=AluJr
ADediting_1104763chr4_122277235_+SINEAluName=AluJr
ADediting_1104764chr4_122277256_+SINEAluName=AluJr
ADediting_1104765chr4_122277267_+SINEAluName=AluJr
ADediting_1104766chr4_122278735_+SINEAluName=AluSz
ADediting_1104767chr4_122278736_+SINEAluName=AluSz
ADediting_1104768chr4_122278758_+SINEAluName=AluSz
ADediting_1104769chr4_122278761_+SINEAluName=AluSz
ADediting_1104770chr4_122278764_+SINEAluName=AluSz
ADediting_1104771chr4_122278789_+SINEAluName=AluSz
ADediting_1104772chr4_122282422_+SINEAluName=AluSx1
ADediting_1104773chr4_122282492_+SINEAluName=AluSx1
ADediting_1104774chr4_122282527_+SINEAluName=AluSx1
ADediting_1104775chr4_122282531_+SINEAluName=AluSx1
ADediting_1104776chr4_122283591_+SINEAluName=AluJr
ADediting_1104777chr4_122283607_+SINEAluName=AluJr
ADediting_1104778chr4_122283640_+SINEAluName=AluJr
ADediting_1104779chr4_122283744_+SINEAluName=AluJr
ADediting_1104780chr4_122283745_+SINEAluName=AluJr
ADediting_1104781chr4_122283772_+SINEAluName=AluJr
ADediting_1104782chr4_122283784_+SINEAluName=AluJr
ADediting_1104783chr4_122292097_+SINEAluName=AluSc
ADediting_1576215chr4_122278712_+SINEAluName=AluSz
ADediting_1650006chr4_122278861_+SINEAluName=AluSz
ADediting_1650007chr4_122282443_+SINEAluName=AluSx1
ADediting_1650008chr4_122282495_+SINEAluName=AluSx1
ADediting_1650009chr4_122282522_+SINEAluName=AluSx1
ADediting_1650010chr4_122283535_+SINEAluName=AluJr
ADediting_1650011chr4_122283543_+SINEAluName=AluJr
ADediting_1650012chr4_122283598_+SINEAluName=AluJr
ADediting_1650013chr4_122283624_+SINEAluName=AluJr
ADediting_1650014chr4_122283673_+SINEAluName=AluJr
ADediting_1650015chr4_122288545_+SINEAluName=AluSx1

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RNA A-to-I editing events in the alternative splicing sites for KIAA1109

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KIAA1109

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for KIAA1109

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for KIAA1109


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_496066chr15_66496985_-ENSG00000138688.15ENST00000446180.5KIAA1109-209hsa-miR-4512chr41222761421222761487mer-m8122276129122276149145-14.79
ADediting_527135chr16_24203190_+ENSG00000138688.15ENST00000264501.8KIAA1109-201hsa-miR-1273h-3pchr41223625261223625327mer-m8122362512122362533140-16.4
ADediting_527135chr16_24203190_+ENSG00000138688.15ENST00000306802.8KIAA1109-202hsa-miR-1273h-3pchr41223625261223625327mer-m8122362512122362533140-16.4
ADediting_527135chr16_24203190_+ENSG00000138688.15ENST00000388738.7KIAA1109-203hsa-miR-1273h-3pchr41223625261223625327mer-m8122362512122362533140-16.4
ADediting_527135chr16_24203190_+ENSG00000138688.15ENST00000438707.5KIAA1109-207hsa-miR-1273h-3pchr41223625261223625327mer-m8122362512122362533140-16.4
ADediting_843620chr2_207754818_+ENSG00000138688.15ENST00000442707.1KIAA1109-208hsa-miR-4775chr41223446021223446098mer-1a122344588122344609142-7.38

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for KIAA1109

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for KIAA1109

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1104729chr4_122155442_+0.835643158384493-0.01183086093150980.03694739166382-0.1185571469884111.76672102805725e-170.457983430702502
DLPFCADediting_1104736chr4_122155598_+0.9449419775472960.003938230366737230.0482706321313941-0.1122698919704171.34387743224316e-190.483865536142425
DLPFCADediting_1104749chr4_122170159_+0.9281786331521930.005140148294692670.149265511677388-0.08210085127371114.9400796985886e-160.438960283361022
CERADediting_1104758chr4_122277127_+7.26237212011897e-060.3571049643841265.84407947943938e-060.360526656623790.1438223250826240.119919690971168
CERADediting_1104759chr4_122277194_+8.46543849043385e-050.3153597045019380.0001025479472701170.3118298458820530.3351393011936620.0792340880632233
CERADediting_1104760chr4_122277202_+7.45124543645268e-050.3176846028191780.0003142557390431830.2902724569653280.1653083281215640.113867563967201
CERADediting_1104765chr4_122277267_+4.23889307351215e-060.3655127197799398.53542551988356e-060.3545355057539210.1448050329629970.119628489333991
CERADediting_1104767chr4_122278736_+1.44339490043591e-060.3816577531715669.2894880861431e-070.3880208591183960.09271411919972050.137770709356333
CERADediting_1104768chr4_122278758_+3.11886791934537e-050.3330646654469482.60219877467552e-060.3729330451572620.01362260075181210.20105549815903
CERADediting_1104769chr4_122278761_+1.12775788523945e-090.471509130917166.04618806051266e-080.4247564436442750.1643654803557780.114120365251221
CERADediting_1104770chr4_122278764_+2.14019136148837e-070.4083049848982933.08909560677249e-070.4033590057954780.127917164226740.124858296320989
CERADediting_1104771chr4_122278789_+0.0004086577933353590.2849617210059334.20634112473254e-050.327874744898830.4416761131044160.0632848681903606

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.27930344346538e-660.7871844773256694.54370562250294e-460.6951702993241090.3667119378173330.051440905813723
AC7.01987532014817e-720.8526747015295251.34007720285493e-550.7943008215165128.90054646799981e-200.533325577403121
PCC1.36887165430713e-600.8721662820747121.16361682167959e-530.8466060260629326.73098257976783e-070.350378718432349
CER8.71248824676366e-480.8720796643588391.32631741314812e-270.7431042666338380.003251128206490710.238801182924485
TCX2.39216456306104e-290.7587739223602846.45299845110043e-060.3589706713858911.92081900269277e-090.465649495736227
FP4.28435004185269e-330.7475221313213564.52024876116973e-320.7395071615271491.87746203924469e-060.348436182614357
IFG1.11685300956641e-080.8743398384523883.1964797635318e-060.7861169936214970.003464257255661720.561914788346384
PG5.63567182755155e-590.8719732237743222.25587657517593e-310.723006289685420.5305182559709020.0462769603223552
STG6.95197878254346e-250.8531038723794852.68026370518152e-180.7789718985472980.0602606985308210.205885576616869

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Relation with AD stages for KIAA1109

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_1104769chr4_122278761_+0.0004099968650902780.33408097850075
CERADediting_1104770chr4_122278764_+0.001171806676967090.308258252503546

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER1.37599817324464e-060.445257172349008
TCX8.50860681951984e-090.523512763422173

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RelatedDrugs for KIAA1109

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1109

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
KIAA1109C0003886Arthrogryposis2GENOMICS_ENGLAND
KIAA1109C0020255Hydrocephalus2GENOMICS_ENGLAND
KIAA1109C3714756Intellectual Disability2GENOMICS_ENGLAND