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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for ULK1

check button Gene summary
Gene informationGene symbol

ULK1

Gene ID

8408

Gene nameunc-51 like autophagy activating kinase 1
SynonymsATG1|ATG1A|UNC51|Unc51.1|hATG1
Cytomap

12q24.33

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homolog
Modification date20200327
UniProtAcc

O75385,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ULK1

GO:0006914

autophagy

18936157

ULK1

GO:0018105

peptidyl-serine phosphorylation

25126726|27103069

ULK1

GO:0018107

peptidyl-threonine phosphorylation

27103069

ULK1

GO:0031333

negative regulation of protein complex assembly

25126726

ULK1

GO:0046777

protein autophosphorylation

18936157


Top

RNA A-to-I events for ULK1

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_329820(131897648, +), ADediting_329821(131897652, +), ADediting_329822(131897654, +), ADediting_329823(131897662, +), ADediting_329824(131897664, +), ADediting_329825(131897716, +), ADediting_329826(131897719, +), ADediting_329827(131897720, +), ADediting_329828(131897764, +), ADediting_329829(131897774, +), ADediting_329830(131897818, +), ADediting_329831(131897819, +), ADediting_329832(131897820, +), ADediting_329833(131897824, +), ADediting_329834(131897833, +), ADediting_329835(131897840, +), ADediting_329836(131897851, +), ADediting_329837(131897859, +), ADediting_329838(131897878, +), ADediting_329839(131897883, +), ADediting_329840(131898215, +), ADediting_329841(131898563, +), ADediting_329842(131898565, +), ADediting_329843(131898566, +), ADediting_329844(131898581, +), ADediting_329845(131898582, +), ADediting_329846(131898601, +), ADediting_329847(131898602, +), ADediting_329848(131898631, +), ADediting_329849(131898687, +), ADediting_329850(131898699, +), ADediting_329851(131898740, +), ADediting_329852(131898758, +), ADediting_329853(131898759, +), ADediting_329854(131898959, +), ADediting_329855(131898978, +), ADediting_329856(131898979, +), ADediting_329857(131899147, +), ADediting_329858(131899244, +), ADediting_329859(131899250, +), ADediting_329860(131899253, +), ADediting_329861(131899269, +), ADediting_329862(131899289, +), ADediting_329863(131899306, +), ADediting_329864(131899318, +), ADediting_329865(131899328, +), ADediting_329866(131899330, +), ADediting_329867(131899368, +), ADediting_329868(131899371, +), ADediting_329869(131899373, +), ADediting_329870(131899377, +), ADediting_329871(131899378, +), ADediting_329872(131899397, +), ADediting_329873(131899407, +), ADediting_329874(131899410, +), ADediting_329875(131899435, +), ADediting_329876(131899450, +), ADediting_329877(131899456, +), ADediting_329878(131899468, +), ADediting_329879(131899522, +), ADediting_329880(131899546, +), ADediting_329881(131899555, +), ADediting_329882(131899585, +), ADediting_329883(131899591, +), ADediting_329884(131899603, +), ADediting_329885(131899848, +), ADediting_329886(131899864, +), ADediting_329887(131899865, +), ADediting_329888(131899870, +), ADediting_329889(131899908, +), ADediting_329890(131899917, +), ADediting_329891(131899942, +), ADediting_329892(131899956, +), ADediting_329893(131899957, +), ADediting_329894(131899961, +), ADediting_329895(131899964, +), ADediting_329896(131899965, +), ADediting_329897(131899967, +), ADediting_329898(131899970, +), ADediting_329899(131899996, +), ADediting_329900(131900002, +), ADediting_329901(131900006, +), ADediting_329902(131900010, +), ADediting_329903(131900013, +), ADediting_329904(131900019, +), ADediting_329905(131900023, +), ADediting_329906(131900029, +), ADediting_329907(131900038, +), ADediting_329908(131900042, +), ADediting_329909(131900058, +), ADediting_329910(131900069, +), ADediting_329911(131901095, +), ADediting_329912(131901103, +), ADediting_329913(131901104, +), ADediting_329914(131901238, +), ADediting_329915(131901248, +), ADediting_329916(131901341, +), ADediting_329917(131904202, +), ADediting_329918(131904276, +), ADediting_329919(131904428, +), ADediting_329920(131906149, +), ADediting_329921(131906168, +), ADediting_329922(131906193, +), ADediting_329923(131906220, +), ADediting_329924(131906223, +), ADediting_329925(131906233, +), ADediting_329926(131906239, +), ADediting_329927(131906265, +), ADediting_329928(131906288, +), ADediting_329929(131906332, +), ADediting_329930(131906351, +), ADediting_329931(131906409, +), ADediting_329932(131906465, +), ADediting_329933(131922592, +), ADediting_1531649(131899031, +), ADediting_1531650(131899034, +), ADediting_1531651(131899207, +), ADediting_1531652(131899355, +), ADediting_1531653(131899449, +), ADediting_1531654(131906137, +),

Top

RNA editing positional annotations for ULK1 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_329820chr12_131897648_+ncRNA_exonic
ADediting_329821chr12_131897652_+ncRNA_exonic
ADediting_329822chr12_131897654_+ncRNA_exonic
ADediting_329823chr12_131897662_+ncRNA_exonic
ADediting_329824chr12_131897664_+ncRNA_exonic
ADediting_329825chr12_131897716_+ncRNA_exonic
ADediting_329826chr12_131897719_+ncRNA_exonic
ADediting_329827chr12_131897720_+ncRNA_exonic
ADediting_329828chr12_131897764_+ncRNA_exonic
ADediting_329829chr12_131897774_+ncRNA_exonic
ADediting_329830chr12_131897818_+ncRNA_exonic
ADediting_329831chr12_131897819_+ncRNA_exonic
ADediting_329832chr12_131897820_+ncRNA_exonic
ADediting_329833chr12_131897824_+ncRNA_exonic
ADediting_329834chr12_131897833_+ncRNA_exonic
ADediting_329835chr12_131897840_+ncRNA_exonic
ADediting_329836chr12_131897851_+ncRNA_exonic
ADediting_329837chr12_131897859_+ncRNA_exonic
ADediting_329838chr12_131897878_+ncRNA_exonic
ADediting_329839chr12_131897883_+ncRNA_exonic
ADediting_329840chr12_131898215_+ncRNA_exonic
ADediting_329841chr12_131898563_+intronic
ADediting_329842chr12_131898565_+intronic
ADediting_329843chr12_131898566_+intronic
ADediting_329844chr12_131898581_+intronic
ADediting_329845chr12_131898582_+intronic
ADediting_329846chr12_131898601_+intronic
ADediting_329847chr12_131898602_+intronic
ADediting_329848chr12_131898631_+intronic
ADediting_329849chr12_131898687_+intronic
ADediting_329850chr12_131898699_+intronic
ADediting_329851chr12_131898740_+intronic
ADediting_329852chr12_131898758_+intronic
ADediting_329853chr12_131898759_+intronic
ADediting_329854chr12_131898959_+intronic
ADediting_329855chr12_131898978_+intronic
ADediting_329856chr12_131898979_+intronic
ADediting_329857chr12_131899147_+intronic
ADediting_329858chr12_131899244_+intronic
ADediting_329859chr12_131899250_+intronic
ADediting_329860chr12_131899253_+intronic
ADediting_329861chr12_131899269_+intronic
ADediting_329862chr12_131899289_+intronic
ADediting_329863chr12_131899306_+intronic
ADediting_329864chr12_131899318_+intronic
ADediting_329865chr12_131899328_+intronic
ADediting_329866chr12_131899330_+intronic
ADediting_329867chr12_131899368_+intronic
ADediting_329868chr12_131899371_+intronic
ADediting_329869chr12_131899373_+intronic
ADediting_329870chr12_131899377_+intronic
ADediting_329871chr12_131899378_+intronic
ADediting_329872chr12_131899397_+intronic
ADediting_329873chr12_131899407_+intronic
ADediting_329874chr12_131899410_+intronic
ADediting_329875chr12_131899435_+intronic
ADediting_329876chr12_131899450_+intronic
ADediting_329877chr12_131899456_+intronic
ADediting_329878chr12_131899468_+intronic
ADediting_329879chr12_131899522_+intronic
ADediting_329880chr12_131899546_+intronic
ADediting_329881chr12_131899555_+intronic
ADediting_329882chr12_131899585_+intronic
ADediting_329883chr12_131899591_+intronic
ADediting_329884chr12_131899603_+intronic
ADediting_329885chr12_131899848_+intronic
ADediting_329886chr12_131899864_+intronic
ADediting_329887chr12_131899865_+intronic
ADediting_329888chr12_131899870_+intronic
ADediting_329889chr12_131899908_+intronic
ADediting_329890chr12_131899917_+intronic
ADediting_329891chr12_131899942_+intronic
ADediting_329892chr12_131899956_+intronic
ADediting_329893chr12_131899957_+intronic
ADediting_329894chr12_131899961_+intronic
ADediting_329895chr12_131899964_+intronic
ADediting_329896chr12_131899965_+intronic
ADediting_329897chr12_131899967_+intronic
ADediting_329898chr12_131899970_+intronic
ADediting_329899chr12_131899996_+intronic
ADediting_329900chr12_131900002_+intronic
ADediting_329901chr12_131900006_+intronic
ADediting_329902chr12_131900010_+intronic
ADediting_329903chr12_131900013_+intronic
ADediting_329904chr12_131900019_+intronic
ADediting_329905chr12_131900023_+intronic
ADediting_329906chr12_131900029_+intronic
ADediting_329907chr12_131900038_+intronic
ADediting_329908chr12_131900042_+intronic
ADediting_329909chr12_131900058_+intronic
ADediting_329910chr12_131900069_+intronic
ADediting_329911chr12_131901095_+intronic
ADediting_329912chr12_131901103_+intronic
ADediting_329913chr12_131901104_+intronic
ADediting_329914chr12_131901238_+intronic
ADediting_329915chr12_131901248_+intronic
ADediting_329916chr12_131901341_+intronic
ADediting_329917chr12_131904202_+intronic
ADediting_329918chr12_131904276_+intronic
ADediting_329919chr12_131904428_+intronic
ADediting_329920chr12_131906149_+intronic
ADediting_329921chr12_131906168_+intronic
ADediting_329922chr12_131906193_+intronic
ADediting_329923chr12_131906220_+intronic
ADediting_329924chr12_131906223_+intronic
ADediting_329925chr12_131906233_+intronic
ADediting_329926chr12_131906239_+intronic
ADediting_329927chr12_131906265_+intronic
ADediting_329928chr12_131906288_+intronic
ADediting_329929chr12_131906332_+intronic
ADediting_329930chr12_131906351_+intronic
ADediting_329931chr12_131906409_+intronic
ADediting_329932chr12_131906465_+intronic
ADediting_329933chr12_131922592_+UTR3
ADediting_1531649chr12_131899031_+intronic
ADediting_1531650chr12_131899034_+intronic
ADediting_1531651chr12_131899207_+intronic
ADediting_1531652chr12_131899355_+intronic
ADediting_1531653chr12_131899449_+intronic
ADediting_1531654chr12_131906137_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_329820chr12_131897648_+SINEAluName=AluJo
ADediting_329821chr12_131897652_+SINEAluName=AluJo
ADediting_329822chr12_131897654_+SINEAluName=AluJo
ADediting_329823chr12_131897662_+SINEAluName=AluJo
ADediting_329824chr12_131897664_+SINEAluName=AluJo
ADediting_329825chr12_131897716_+SINEAluName=AluJo
ADediting_329826chr12_131897719_+SINEAluName=AluJo
ADediting_329827chr12_131897720_+SINEAluName=AluJo
ADediting_329828chr12_131897764_+SINEAluName=AluJo
ADediting_329829chr12_131897774_+SINEAluName=AluJo
ADediting_329830chr12_131897818_+SINEAluName=AluJo
ADediting_329831chr12_131897819_+SINEAluName=AluJo
ADediting_329832chr12_131897820_+SINEAluName=AluJo
ADediting_329833chr12_131897824_+SINEAluName=AluJo
ADediting_329834chr12_131897833_+SINEAluName=AluJo
ADediting_329835chr12_131897840_+SINEAluName=AluJo
ADediting_329836chr12_131897851_+SINEAluName=AluJo
ADediting_329837chr12_131897859_+SINEAluName=AluJo
ADediting_329838chr12_131897878_+SINEAluName=AluJo
ADediting_329839chr12_131897883_+SINEAluName=AluJo
ADediting_329841chr12_131898563_+SINEAluName=AluSq2
ADediting_329842chr12_131898565_+SINEAluName=AluSq2
ADediting_329843chr12_131898566_+SINEAluName=AluSq2
ADediting_329844chr12_131898581_+SINEAluName=AluSq2
ADediting_329845chr12_131898582_+SINEAluName=AluSq2
ADediting_329846chr12_131898601_+SINEAluName=AluSq2
ADediting_329847chr12_131898602_+SINEAluName=AluSq2
ADediting_329848chr12_131898631_+SINEAluName=AluSq2
ADediting_329849chr12_131898687_+SINEAluName=AluSq2
ADediting_329850chr12_131898699_+SINEAluName=AluSq2
ADediting_329851chr12_131898740_+SINEAluName=AluSq2
ADediting_329852chr12_131898758_+SINEAluName=AluSq2
ADediting_329853chr12_131898759_+SINEAluName=AluSq2
ADediting_329854chr12_131898959_+SINEAluName=AluSx1
ADediting_329855chr12_131898978_+SINEAluName=AluSx1
ADediting_329856chr12_131898979_+SINEAluName=AluSx1
ADediting_329857chr12_131899147_+SINEAluName=AluSx1
ADediting_329858chr12_131899244_+SINEAluName=AluSp
ADediting_329859chr12_131899250_+SINEAluName=AluSp
ADediting_329860chr12_131899253_+SINEAluName=AluSp
ADediting_329861chr12_131899269_+SINEAluName=AluSp
ADediting_329862chr12_131899289_+SINEAluName=AluSp
ADediting_329863chr12_131899306_+SINEAluName=AluSp
ADediting_329864chr12_131899318_+SINEAluName=AluSp
ADediting_329865chr12_131899328_+SINEAluName=AluSp
ADediting_329866chr12_131899330_+SINEAluName=AluSp
ADediting_329867chr12_131899368_+SINEAluName=AluSp
ADediting_329868chr12_131899371_+SINEAluName=AluSp
ADediting_329869chr12_131899373_+SINEAluName=AluSp
ADediting_329870chr12_131899377_+SINEAluName=AluSp
ADediting_329871chr12_131899378_+SINEAluName=AluSp
ADediting_329872chr12_131899397_+SINEAluName=AluSp
ADediting_329873chr12_131899407_+SINEAluName=AluSp
ADediting_329874chr12_131899410_+SINEAluName=AluSp
ADediting_329875chr12_131899435_+SINEAluName=AluSp
ADediting_329876chr12_131899450_+SINEAluName=AluSp
ADediting_329877chr12_131899456_+SINEAluName=AluSp
ADediting_329878chr12_131899468_+SINEAluName=AluSp
ADediting_329879chr12_131899522_+SINEAluName=AluJr
ADediting_329880chr12_131899546_+SINEAluName=AluJr
ADediting_329881chr12_131899555_+SINEAluName=AluJr
ADediting_329882chr12_131899585_+SINEAluName=AluJr
ADediting_329883chr12_131899591_+SINEAluName=AluJr
ADediting_329884chr12_131899603_+SINEAluName=AluJr
ADediting_329885chr12_131899848_+SINEAluName=AluSc
ADediting_329886chr12_131899864_+SINEAluName=AluSc
ADediting_329887chr12_131899865_+SINEAluName=AluSc
ADediting_329888chr12_131899870_+SINEAluName=AluSc
ADediting_329889chr12_131899908_+SINEAluName=AluSc
ADediting_329890chr12_131899917_+SINEAluName=AluSc
ADediting_329891chr12_131899942_+SINEAluName=AluSc
ADediting_329892chr12_131899956_+SINEAluName=AluSc
ADediting_329893chr12_131899957_+SINEAluName=AluSc
ADediting_329894chr12_131899961_+SINEAluName=AluSc
ADediting_329895chr12_131899964_+SINEAluName=AluSc
ADediting_329896chr12_131899965_+SINEAluName=AluSc
ADediting_329897chr12_131899967_+SINEAluName=AluSc
ADediting_329898chr12_131899970_+SINEAluName=AluSc
ADediting_329899chr12_131899996_+SINEAluName=AluSc
ADediting_329900chr12_131900002_+SINEAluName=AluSc
ADediting_329901chr12_131900006_+SINEAluName=AluSc
ADediting_329902chr12_131900010_+SINEAluName=AluSc
ADediting_329903chr12_131900013_+SINEAluName=AluSc
ADediting_329904chr12_131900019_+SINEAluName=AluSc
ADediting_329905chr12_131900023_+SINEAluName=AluSc
ADediting_329906chr12_131900029_+SINEAluName=AluSc
ADediting_329907chr12_131900038_+SINEAluName=AluSc
ADediting_329908chr12_131900042_+SINEAluName=AluSc
ADediting_329909chr12_131900058_+SINEAluName=AluSc
ADediting_329910chr12_131900069_+SINEAluName=AluSc
ADediting_329911chr12_131901095_+SINEAluName=AluSx1
ADediting_329912chr12_131901103_+SINEAluName=AluSx1
ADediting_329913chr12_131901104_+SINEAluName=AluSx1
ADediting_329914chr12_131901238_+SINEAluName=AluSx1
ADediting_329915chr12_131901248_+SINEAluName=AluSx1
ADediting_329916chr12_131901341_+SINEAluName=AluSx1
ADediting_329917chr12_131904202_+SINEAluName=AluJb
ADediting_329918chr12_131904276_+SINEAluName=AluJb
ADediting_329919chr12_131904428_+SINEAluName=AluJb
ADediting_329920chr12_131906149_+SINEAluName=AluSg
ADediting_329921chr12_131906168_+SINEAluName=AluSg
ADediting_329922chr12_131906193_+SINEAluName=AluSg
ADediting_329923chr12_131906220_+SINEAluName=AluSg
ADediting_329924chr12_131906223_+SINEAluName=AluSg
ADediting_329925chr12_131906233_+SINEAluName=AluSg
ADediting_329926chr12_131906239_+SINEAluName=AluSg
ADediting_329927chr12_131906265_+SINEAluName=AluSg
ADediting_329928chr12_131906288_+SINEAluName=AluSg
ADediting_329929chr12_131906332_+SINEAluName=AluSg
ADediting_329930chr12_131906351_+SINEAluName=AluSg
ADediting_329931chr12_131906409_+SINEAluName=AluSg
ADediting_329932chr12_131906465_+SINEAluName=AluSg
ADediting_1531649chr12_131899031_+SINEAluName=AluSx1
ADediting_1531650chr12_131899034_+SINEAluName=AluSx1
ADediting_1531651chr12_131899207_+SINEAluName=AluSp
ADediting_1531652chr12_131899355_+SINEAluName=AluSp
ADediting_1531653chr12_131899449_+SINEAluName=AluSp
ADediting_1531654chr12_131906137_+SINEAluName=AluSg

Top

RNA A-to-I editing events in the alternative splicing sites for ULK1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for ULK1

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
Soverview

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for ULK1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ULK1

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_329933chr12_131922592_+ENSG00000177169.10ENST00000321867.6ULK1-201hsa-miR-10394-5pchr121319225851319225928mer-1a131922572131922592150-25.76
ADediting_329933chr12_131922592_+ENSG00000177169.10ENST00000321867.6ULK1-201hsa-miR-4527chr121319225881319225947mer-m8131922575131922595150-20.33
ADediting_329933chr12_131922592_+ENSG00000177169.10ENST00000321867.6ULK1-201hsa-miR-6503-5pchr121319225881319225947mer-m8131922573131922595147-21.67

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ULK1

check button - RNA A-to-I editing in mRNA.
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ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000321867.6protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_329933ENST00000321867.6chr12_131922592_+4764-2353.80-2352.70-2353.80

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ULK1

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_1531650chr12_131899034_+0.01386367411159110.2005535496794226.8844672960268e-050.3191164307899250.00232334353634750.246864623290108
CERADediting_329825chr12_131897716_+0.0005554794876780010.2786205373712554.99272031199563e-070.396765352113350.001263730220404010.26085513836134
CERADediting_329826chr12_131897719_+0.001280578350019620.2605588147642322.78262796488604e-060.3719243926747560.003144887601047160.239610206737289
CERADediting_329829chr12_131897774_+0.0005095021969755540.2804205470659099.00807744307902e-060.3536731210250030.4133505723094730.0672774553847442
CERADediting_329830chr12_131897818_+0.0001047278846475740.3114399236678382.56872942810673e-050.3363824587164270.00646795455457490.221422772372161
TCXADediting_329830chr12_131897818_+0.286165155600930.08765074792435140.586968285735581-0.04470672514271687.20069989712241e-070.391638468588913
CERADediting_329831chr12_131897819_+0.0001864595108568270.3005296448707170.0002324547854796520.2962437358696940.2433014217406170.0958490514149868
TCXADediting_329831chr12_131897819_+0.452403497995660.06181108266882740.121870695998589-0.1268598619568351.77445750426796e-070.410800221204847
CERADediting_329833chr12_131897824_+3.41308097398499e-050.3315104185573979.4354971546122e-080.4190638696257960.02829462050718350.179119760231814
TCXADediting_329833chr12_131897824_+0.5259802295392360.05217968576298490.272424512141317-0.09018187931150426.50193563347594e-070.393076298582501
CERADediting_329837chr12_131897859_+8.6666096892597e-070.3890109171934734.80903018391099e-120.5259241683178280.01781605454921940.193251524646235
CERADediting_329838chr12_131897878_+0.000197762972987250.2993920581344581.41213150964184e-050.3463796832007510.08280643306457190.142101014026509
CERADediting_329841chr12_131898563_+0.0002791514687424550.292633894422526.96101335974555e-050.3189167445950130.004875102656622210.228716266874093
CERADediting_329844chr12_131898581_+0.003659881051135750.235895708516934.97668154241614e-050.3249152372103370.01194410383430990.204783317050524
CERADediting_329850chr12_131898699_+0.001684904304297250.2543416626911561.99158477657016e-050.3406765621830490.009446088747789510.211288914100538
CERADediting_329851chr12_131898740_+0.001383028825731590.2588300630728422.49075734118696e-060.3735897726278610.3686151288332210.0739267151594523
CERADediting_329857chr12_131899147_+0.001524774638476210.2566216912241266.89954043713448e-070.3922410790621080.01163966486134120.205508218605805
CERADediting_329859chr12_131899250_+0.008743765703181340.2133918125559446.41469676905052e-050.3203894812547260.000629847261281330.275981031629019
CERADediting_329861chr12_131899269_+0.00653959138057550.2211340872060534.20001975125339e-050.3279010746048730.002526496630125940.244877041279287
CERADediting_329867chr12_131899368_+0.0009640987960100480.2668375565189530.0001176492589353570.3092734745450140.07360444496527660.146512818971226
CERADediting_329871chr12_131899378_+0.002302037825600220.2470821081455185.05585381345474e-050.3246359000849190.01033434583909140.208818637286202
CERADediting_329877chr12_131899456_+2.12614173613864e-050.3395794080018621.29601843265646e-050.3477857478378730.007346451721606650.218063326447899
CERADediting_329884chr12_131899603_+0.0006287284747994890.2760185627419240.0001070010866108390.3110413122642340.04015968550818630.16776745517352
CERADediting_329886chr12_131899864_+0.0002614296385988830.2939327528024936.252649217604e-060.3594666868642510.1170700213747370.128504491625917
CERADediting_329887chr12_131899865_+3.35241459795709e-050.3318203057194540.0001991907494902430.2992526927163370.2813364516085330.0885307241791957
CERADediting_329888chr12_131899870_+9.90742511102871e-070.3870992935886617.43661090845546e-080.422121963232320.2399944362104040.0965216695922422
CERADediting_329889chr12_131899908_+0.0009982467548762310.2660757671990032.06203177825989e-050.3400937285585340.003527871632052150.23680062532972
CERADediting_329891chr12_131899942_+0.07919921852440370.1437809723410090.03291458762354450.1742914774620420.0001685835949327530.302466849335401
CERADediting_329901chr12_131900006_+0.0866728014570770.1403643276527930.001009334058668550.2658335576513870.0001030071832454290.311747063496198
CERADediting_329906chr12_131900029_+0.005809157014419970.2242201533810294.42528611350535e-060.3648493827096810.006089901767210450.222995152362882
CERADediting_329907chr12_131900038_+0.05625730750991660.1562206779931260.0001884513926371240.3003246046995620.02617817079444050.181559947709304
CERADediting_329920chr12_131906149_+0.002504220048487740.2450877727219447.58867364615258e-070.3908966239421010.02087622948990170.188510835650432
CERADediting_329924chr12_131906223_+0.0006065446460490090.2767757379720945.11059220994511e-050.3244451603725550.03767168259365020.169886963499373

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC7.31329621421574e-430.6767391610279411.19036253473047e-530.7338128866411233.8922419978403e-140.412063261643987
AC8.70834562377235e-100.3753932552790444.96082526988363e-140.4526387187830230.08185283102791360.11026627538749
PCC1.46939824195575e-110.4634178709874541.15357261707094e-120.4850411250308941.75047080430508e-060.337880314868058
CER1.31327333392106e-080.4435266851556771.42215034365738e-210.6785469174631197.80274349996277e-060.355966010489553
TCX1.00432626449445e-200.6679056589896522.44739698743459e-310.7753058779828980.887059876700818-0.0116937596447905
FP5.25585167827915e-110.4665290820716810.0001166633595175440.2847996910538692.78073384992066e-140.530027142151953
IFG0.0001218442200016890.6933062927120662.0580643382111e-060.7949917365120610.01316635398097860.488764276366618
STG2.71018867254977e-050.4408074665059120.002306765046081520.3281766546205450.0002631246290344440.388233019059679

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Relation with AD stages for ULK1

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_329825chr12_131897716_+1.89632920266391e-060.439948988439502
CERADediting_329826chr12_131897719_+0.0009573768805491730.313408645655761
CERADediting_329830chr12_131897818_+0.0006418766842234010.323335935567839
CERADediting_329833chr12_131897824_+0.0002550116539682460.345054491530876
CERADediting_329837chr12_131897859_+0.0006782770994648790.321986176645773
CERADediting_329848chr12_131898631_+2.01904112873547e-050.397757230962056
CERADediting_329850chr12_131898699_+1.21912148242195e-070.482711554421296
CERADediting_329851chr12_131898740_+0.0005537362029028820.32692009740282
CERADediting_329859chr12_131899250_+0.000104648456585130.364616686002849
CERADediting_329861chr12_131899269_+0.0001006945217398610.365434768704695
CERADediting_329864chr12_131899318_+0.0001189468324245060.361880509158159
CERADediting_329867chr12_131899368_+0.0002995759558602920.341377469151964
CERADediting_329871chr12_131899378_+0.001130445423605430.309180743060647
CERADediting_329873chr12_131899407_+7.62751699369294e-060.41581508773669
CERADediting_329877chr12_131899456_+0.001068700515786680.310616768406733
CERADediting_329889chr12_131899908_+1.68006256371843e-050.401247735522736
CERADediting_329891chr12_131899942_+0.001476983088273690.302244636631529
CERADediting_329894chr12_131899961_+0.0005913518937459020.325330710127701
CERADediting_329899chr12_131899996_+0.0004815550895732440.330269516765312
CERADediting_329902chr12_131900010_+0.001319515734813170.305189464768507
CERADediting_329926chr12_131906239_+6.32602168409005e-050.375139076384583
CERADediting_329928chr12_131906288_+0.0001725217667356340.353793453080949
TCXADediting_329830chr12_131897818_+0.001210205471362950.310237481054366

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER5.18297418259845e-080.494931620871802

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RelatedDrugs for ULK1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
ULK1O75385DB12010FostamatinibSerine/threonine-protein kinase ULK1small moleculeapproved|investigational

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RelatedDiseases for ULK1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
ULK1C1335167Ovarian Mucinous Adenocarcinoma1UNIPROT