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	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene

Gene summary for CCDC8

Gene summary

Gene information	Gene symbol	CCDC8
	Gene ID	83987
	Gene name	coiled-coil domain containing 8
	Synonyms	3M3|PPP1R20|p90
	Cytomap	19q13.32
	Type of gene	protein-coding
	Description	coiled-coil domain-containing protein 8protein phosphatase 1, regulatory subunit 20
	Modification date	20200313
	UniProtAcc	Q9H0W5,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CCDC8	GO:0010923	negative regulation of phosphatase activity	19389623

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RNA A-to-I events for CCDC8

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_765069(46410900, -), ADediting_765070(46410911, -), ADediting_765071(46410912, -), ADediting_765072(46410939, -), ADediting_765073(46410940, -), ADediting_765074(46410953, -), ADediting_765075(46410954, -), ADediting_765076(46411008, -), ADediting_765077(46411016, -),

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RNA editing positional annotations for CCDC8 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_765069	chr19_46410900_-	UTR3
ADediting_765070	chr19_46410911_-	UTR3
ADediting_765071	chr19_46410912_-	UTR3
ADediting_765072	chr19_46410939_-	UTR3
ADediting_765073	chr19_46410940_-	UTR3
ADediting_765074	chr19_46410953_-	UTR3
ADediting_765075	chr19_46410954_-	UTR3
ADediting_765076	chr19_46411008_-	UTR3
ADediting_765077	chr19_46411016_-	UTR3

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_765069	chr19_46410900_-	SINE	Alu	Name=AluJo
ADediting_765070	chr19_46410911_-	SINE	Alu	Name=AluJo
ADediting_765071	chr19_46410912_-	SINE	Alu	Name=AluJo
ADediting_765072	chr19_46410939_-	SINE	Alu	Name=AluJo
ADediting_765073	chr19_46410940_-	SINE	Alu	Name=AluJo
ADediting_765074	chr19_46410953_-	SINE	Alu	Name=AluJo
ADediting_765075	chr19_46410954_-	SINE	Alu	Name=AluJo
ADediting_765076	chr19_46411008_-	SINE	Alu	Name=AluJo
ADediting_765077	chr19_46411016_-	SINE	Alu	Name=AluJo

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RNA A-to-I editing events in the alternative splicing sites for CCDC8

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CCDC8

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs