|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for CCDC8 |
 Gene summary |
| Gene information | Gene symbol | CCDC8 | Gene ID | 83987 |
| Gene name | coiled-coil domain containing 8 | |
| Synonyms | 3M3|PPP1R20|p90 | |
| Cytomap | 19q13.32 | |
| Type of gene | protein-coding | |
| Description | coiled-coil domain-containing protein 8protein phosphatase 1, regulatory subunit 20 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9H0W5, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CCDC8 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
Top |
RNA A-to-I events for CCDC8 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_765069(46410900, -), ADediting_765070(46410911, -), ADediting_765071(46410912, -), ADediting_765072(46410939, -), ADediting_765073(46410940, -), ADediting_765074(46410953, -), ADediting_765075(46410954, -), ADediting_765076(46411008, -), ADediting_765077(46411016, -), |
Top |
RNA editing positional annotations for CCDC8 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_765069 | chr19_46410900_- | UTR3 |
| ADediting_765070 | chr19_46410911_- | UTR3 |
| ADediting_765071 | chr19_46410912_- | UTR3 |
| ADediting_765072 | chr19_46410939_- | UTR3 |
| ADediting_765073 | chr19_46410940_- | UTR3 |
| ADediting_765074 | chr19_46410953_- | UTR3 |
| ADediting_765075 | chr19_46410954_- | UTR3 |
| ADediting_765076 | chr19_46411008_- | UTR3 |
| ADediting_765077 | chr19_46411016_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_765069 | chr19_46410900_- | SINE | Alu | Name=AluJo |
| ADediting_765070 | chr19_46410911_- | SINE | Alu | Name=AluJo |
| ADediting_765071 | chr19_46410912_- | SINE | Alu | Name=AluJo |
| ADediting_765072 | chr19_46410939_- | SINE | Alu | Name=AluJo |
| ADediting_765073 | chr19_46410940_- | SINE | Alu | Name=AluJo |
| ADediting_765074 | chr19_46410953_- | SINE | Alu | Name=AluJo |
| ADediting_765075 | chr19_46410954_- | SINE | Alu | Name=AluJo |
| ADediting_765076 | chr19_46411008_- | SINE | Alu | Name=AluJo |
| ADediting_765077 | chr19_46411016_- | SINE | Alu | Name=AluJo |
Top |
RNA A-to-I editing events in the alternative splicing sites for CCDC8 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for CCDC8 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for CCDC8 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for CCDC8 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_765070 | chr19_46410911_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-383-3p | chr19 | 46410906 | 46410912 | 7mer-m8 | 46410905 | 46410923 | 140 | -16.5 |
| ADediting_765072 | chr19_46410939_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-3622a-3p | chr19 | 46410935 | 46410942 | 8mer-1a | 46410935 | 46410956 | 141 | -15.97 |
| ADediting_765072 | chr19_46410939_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-3622b-3p | chr19 | 46410935 | 46410942 | 8mer-1a | 46410935 | 46410955 | 148 | -19.16 |
| ADediting_765072 | chr19_46410939_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-4649-3p | chr19 | 46410939 | 46410945 | 7mer-m8 | 46410938 | 46410958 | 147 | -18.89 |
| ADediting_765072 | chr19_46410939_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-544b | chr19 | 46410938 | 46410944 | 7mer-m8 | 46410937 | 46410958 | 150 | -16.46 |
| ADediting_765074 | chr19_46410953_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-12119 | chr19 | 46410952 | 46410958 | 7mer-m8 | 46410951 | 46410976 | 158 | -18.65 |
| ADediting_765074 | chr19_46410953_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-4649-3p | chr19 | 46410952 | 46410959 | 8mer-1a | 46410952 | 46410971 | 146 | -18.18 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-340-3p | chr19 | 46411015 | 46411021 | 7mer-m8 | 46411014 | 46411036 | 155 | -15.89 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-6827-3p | chr19 | 46411015 | 46411021 | 7mer-m8 | 46411014 | 46411034 | 145 | -16.55 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_765069 | chr19_46410900_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-3686 | chr19 | 46410896 | 46410902 | 7mer-m8 | 46410895 | 46410916 | 140 | -12.44 |
| ADediting_765070 | chr19_46410911_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-4310 | chr19 | 46410906 | 46410912 | 7mer-m8 | 46410905 | 46410920 | 140 | -8.38 |
| ADediting_765070 | chr19_46410911_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-7157-5p | chr19 | 46410906 | 46410912 | 7mer-m8 | 46410905 | 46410925 | 149 | -18.74 |
| ADediting_765076 | chr19_46411008_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-5586-3p | chr19 | 46411004 | 46411010 | 7mer-m8 | 46411003 | 46411024 | 154 | -18.69 |
| ADediting_765076 | chr19_46411008_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-759 | chr19 | 46411003 | 46411009 | 7mer-m8 | 46411002 | 46411022 | 145 | -14.98 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-10a-5p | chr19 | 46411012 | 46411018 | 7mer-m8 | 46411011 | 46411033 | 148 | -14.37 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-10b-5p | chr19 | 46411012 | 46411018 | 7mer-m8 | 46411011 | 46411034 | 148 | -13.93 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-339-5p | chr19 | 46411013 | 46411019 | 7mer-m8 | 46411012 | 46411033 | 153 | -17.11 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-4725-5p | chr19 | 46411011 | 46411017 | 7mer-m8 | 46411010 | 46411030 | 140 | -15.96 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-504-5p | chr19 | 46411011 | 46411017 | 7mer-m8 | 46411010 | 46411032 | 146 | -19.1 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-5699-3p | chr19 | 46411014 | 46411020 | 7mer-m8 | 46411013 | 46411034 | 146 | -16.39 |
| ADediting_765077 | chr19_46411016_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-6818-3p | chr19 | 46411016 | 46411022 | 7mer-m8 | 46411015 | 46411036 | 140 | -11.1 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-589-3p | chr19 | 46410568 | 46410574 | 7mer-m8 | 46410567 | 46410590 | 162 | -21.95 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-589-3p | chr19 | 46411133 | 46411139 | 7mer-m8 | 46411132 | 46411154 | 152 | -22.29 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000169515.8 | ENST00000307522.5 | CCDC8-201 | hsa-miR-4477b | chr19 | 46410769 | 46410776 | 8mer-1a | 46410769 | 46410790 | 147 | -11.13 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
| Differentially expressed lncRNA-miRNA network |
 |
Top |
The effects of the RNA editing to the stability of the RNA structures for CCDC8 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000307522.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_765069 | ENST00000307522.5 | chr19_46410900_- | 2665 | -1372.80 | -1372.60 | -1381.50 |
| ADediting_765070 | ENST00000307522.5 | chr19_46410911_- | 2654 | -1372.60 | -1372.60 | -1381.50 |
| ADediting_765071 | ENST00000307522.5 | chr19_46410912_- | 2653 | -1372.60 | -1372.60 | -1381.50 |
| ADediting_765072 | ENST00000307522.5 | chr19_46410939_- | 2626 | -1374.70 | -1372.60 | -1381.50 |
| ADediting_765073 | ENST00000307522.5 | chr19_46410940_- | 2625 | -1373.70 | -1372.60 | -1381.50 |
| ADediting_765074 | ENST00000307522.5 | chr19_46410953_- | 2612 | -1372.60 | -1372.60 | -1381.50 |
| ADediting_765075 | ENST00000307522.5 | chr19_46410954_- | 2611 | -1372.80 | -1372.60 | -1381.50 |
| ADediting_765076 | ENST00000307522.5 | chr19_46411008_- | 2557 | -1373.10 | -1372.60 | -1381.50 |
| ADediting_765077 | ENST00000307522.5 | chr19_46411016_- | 2549 | -1373.90 | -1372.60 | -1381.50 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for CCDC8 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.000167972877124032 | 0.212136360451316 | 0.0166230353964027 | 0.135940665669068 | 1.36282650914747e-30 | 0.591092524163934 |
| AC | 3.14383572738055e-28 | 0.622596028232267 | 6.00338395281199e-12 | 0.417191581500558 | 1.59231365650515e-19 | 0.530193306320086 |
| PCC | 2.41468323269904e-05 | 0.300422887991178 | 0.0256477983403676 | 0.161464854573947 | 4.6398115894102e-09 | 0.408063088219152 |
| CER | 0.399634528852204 | 0.0692682026062495 | 0.102403854172378 | -0.133878090870188 | 3.14436084023041e-08 | 0.432933524538117 |
| TCX | 0.0389685219797716 | 0.168767990005598 | 0.0159871091132824 | -0.196433936180013 | 4.19813975951528e-08 | 0.429345349445174 |
| FP | 0.0920100285451882 | 0.12667096661124 | 0.923392963153051 | 0.00725859117651974 | 9.04681594374345e-09 | 0.414217296658542 |
| IFG | 0.229135988763839 | 0.249463644750949 | 0.244906173166052 | 0.241462952447114 | 0.0168374017025007 | 0.473399172177257 |
| PG | 0.163787439051493 | -0.102520979040384 | 0.0187009255008165 | -0.172286077448817 | 1.76634788687922e-10 | 0.446043257214542 |
| STG | 0.708675085707097 | -0.0413694530865382 | 0.10063173803774 | -0.18036506888218 | 0.00209648186774407 | 0.331083002667939 |
Top |
Relation with AD stages for CCDC8 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 3.17965630233495e-07 | 0.472386439224665 |
Top |
RelatedDrugs for CCDC8 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CCDC8 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|