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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TMEM120A |
 Gene summary |
| Gene information | Gene symbol | TMEM120A | Gene ID | 83862 |
| Gene name | transmembrane protein 120A | |
| Synonyms | NET29|TMPIT | |
| Cytomap | 7q11.23 | |
| Type of gene | protein-coding | |
| Description | transmembrane protein 120Atransmembrane protein induced by tumor necrosis factor alpha | |
| Modification date | 20200313 | |
| UniProtAcc | Q9BXJ8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TMEM120A | GO:0051260 | protein homooligomerization | 26024229 |
| TMEM120A | GO:0051291 | protein heterooligomerization | 26024229 |
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RNA A-to-I events for TMEM120A |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1365832(75990264, -), ADediting_1365833(75990629, -), ADediting_1365834(75990641, -), ADediting_1365835(75990642, -), ADediting_1365836(75990764, -), ADediting_1365837(75990777, -), ADediting_1365838(75990816, -), ADediting_1365839(75990836, -), ADediting_1365840(75991502, -), ADediting_1365841(75991503, -), ADediting_1365842(75991508, -), ADediting_1365843(75991534, -), ADediting_1365844(75991543, -), ADediting_1365845(75991554, -), ADediting_1365846(75991601, -), ADediting_1365847(75992899, -), ADediting_1365848(75992914, -), ADediting_1588724(75991764, -), ADediting_1588725(75992900, -), |
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RNA editing positional annotations for TMEM120A using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1365832 | chr7_75990264_- | intronic |
| ADediting_1365833 | chr7_75990629_- | intronic |
| ADediting_1365834 | chr7_75990641_- | intronic |
| ADediting_1365835 | chr7_75990642_- | intronic |
| ADediting_1365836 | chr7_75990764_- | intronic |
| ADediting_1365837 | chr7_75990777_- | intronic |
| ADediting_1365838 | chr7_75990816_- | intronic |
| ADediting_1365839 | chr7_75990836_- | intronic |
| ADediting_1365840 | chr7_75991502_- | intronic |
| ADediting_1365841 | chr7_75991503_- | intronic |
| ADediting_1365842 | chr7_75991508_- | intronic |
| ADediting_1365843 | chr7_75991534_- | intronic |
| ADediting_1365844 | chr7_75991543_- | intronic |
| ADediting_1365845 | chr7_75991554_- | intronic |
| ADediting_1365846 | chr7_75991601_- | intronic |
| ADediting_1365847 | chr7_75992899_- | intronic |
| ADediting_1365848 | chr7_75992914_- | intronic |
| ADediting_1588724 | chr7_75991764_- | intronic |
| ADediting_1588725 | chr7_75992900_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1365833 | chr7_75990629_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365834 | chr7_75990641_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365835 | chr7_75990642_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365836 | chr7_75990764_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365837 | chr7_75990777_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365838 | chr7_75990816_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365839 | chr7_75990836_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365840 | chr7_75991502_- | SINE | Alu | Name=AluSz |
| ADediting_1365841 | chr7_75991503_- | SINE | Alu | Name=AluSz |
| ADediting_1365842 | chr7_75991508_- | SINE | Alu | Name=AluSz |
| ADediting_1365843 | chr7_75991534_- | SINE | Alu | Name=AluSz |
| ADediting_1365844 | chr7_75991543_- | SINE | Alu | Name=AluSz |
| ADediting_1365845 | chr7_75991554_- | SINE | Alu | Name=AluSz |
| ADediting_1365846 | chr7_75991601_- | SINE | Alu | Name=AluSz |
| ADediting_1365847 | chr7_75992899_- | SINE | Alu | Name=AluSx1 |
| ADediting_1365848 | chr7_75992914_- | SINE | Alu | Name=AluSx1 |
| ADediting_1588724 | chr7_75991764_- | SINE | Alu | Name=AluJo |
| ADediting_1588725 | chr7_75992900_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for TMEM120A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM120A |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TMEM120A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TMEM120A |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_98288 | chr1_32086990_+ | ENSG00000189077.11 | ENST00000493111.7 | TMEM120A-214 | hsa-miR-5585-3p | chr7 | 75986872 | 75986878 | 7mer-m8 | 75986871 | 75986894 | 165 | -24.16 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TMEM120A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TMEM120A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1365832 | chr7_75990264_- | 2.53065590305552e-06 | 0.263586235490383 | 6.98629006316096e-09 | 0.321449216259815 | 0.00102126117923303 | 0.185678185593223 |
| CER | ADediting_1365833 | chr7_75990629_- | 0.288196774748934 | 0.0872834783287514 | 0.00016699465851222 | 0.302648183845357 | 0.0836053030132181 | 0.1417369346021 |
| CER | ADediting_1365836 | chr7_75990764_- | 0.0204412180843368 | 0.189146506916346 | 1.4379890092053e-05 | 0.34608146908737 | 0.330389810200611 | 0.0800138268152941 |
| CER | ADediting_1365837 | chr7_75990777_- | 0.0173550262396683 | 0.194025979190268 | 1.0232188172654e-07 | 0.418015640584976 | 0.0540778814782426 | 0.157608622305732 |
| CER | ADediting_1365838 | chr7_75990816_- | 0.0458567433786735 | 0.163300660436146 | 6.01569096661397e-06 | 0.360073146382042 | 0.0206170149983301 | 0.188888226645371 |
| CER | ADediting_1365839 | chr7_75990836_- | 0.029372524029334 | 0.177936326726176 | 1.79155643427467e-08 | 0.439799989636997 | 0.27893401192253 | 0.0889723220360506 |
| CER | ADediting_1365846 | chr7_75991601_- | 0.190269612450674 | 0.107532434041672 | 3.23908353709496e-06 | 0.369626391112991 | 0.0116407081846988 | 0.205505706055034 |
| CER | ADediting_1588724 | chr7_75991764_- | 0.0292934596157229 | 0.178021863157857 | 6.37585306216161e-06 | 0.359159914600091 | 0.108125910851477 | 0.131714037620907 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.46310234343044e-15 | 0.425702394054226 | 3.36991779821514e-25 | 0.543260535265217 | 5.95808612795853e-06 | 0.25396317040344 |
| AC | 8.26769420676938e-72 | 0.852463672921124 | 1.63379695142686e-48 | 0.761020172433166 | 1.36738379969063e-15 | 0.476726046645496 |
| PCC | 2.09510881367286e-10 | 0.439090879180868 | 1.07850614673388e-10 | 0.445352267987278 | 0.00545078076416575 | 0.200361463966711 |
| CER | 0.0252962811094717 | 0.182626820458733 | 1.85407999233262e-05 | 0.341872440903834 | 2.15958001490072e-07 | 0.408184390234268 |
| TCX | 3.20435478757048e-05 | 0.332599319605253 | 0.524934442435503 | 0.0523114392568257 | 4.75875666395933e-10 | 0.480774802210602 |
| FP | 1.43601319009967e-19 | 0.610618631719165 | 9.55497968397124e-20 | 0.612964381284843 | 2.62283172169409e-08 | 0.4021922916503 |
| IFG | 6.29728165272064e-05 | 0.71316304356496 | 8.99453850493498e-06 | 0.763512917107004 | 0.0295263794735408 | 0.43557696645213 |
| STG | 1.93551539984784e-10 | 0.625901498310544 | 0.000389254199615503 | 0.378222752873082 | 0.00128364141405525 | 0.345576867447668 |
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Relation with AD stages for TMEM120A |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1365837 | chr7_75990777_- | 0.000311870599283338 | 0.340452128002935 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 4.66343266105779e-05 | 0.381342009777979 |
| TCX | 1.98145915683729e-07 | 0.479557576240412 |
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RelatedDrugs for TMEM120A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM120A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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