ADeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for SLC25A18

check button Gene summary
Gene informationGene symbol

SLC25A18

Gene ID

83733

Gene namesolute carrier family 25 member 18
SynonymsGC2
Cytomap

22q11.21

Type of geneprotein-coding
Descriptionmitochondrial glutamate carrier 2glutamate/H(+) symporter 2solute carrier family 25 (glutamate carrier), member 18solute carrier family 25 (mitochondrial carrier), member 18
Modification date20200313
UniProtAcc

Q9H1K4,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

Top

RNA A-to-I events for SLC25A18

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_965145(17570516, +), ADediting_965146(17570546, +), ADediting_965147(17570624, +), ADediting_965148(17570754, +), ADediting_965149(17570760, +), ADediting_965150(17571549, +), ADediting_965151(17571573, +), ADediting_965152(17571611, +), ADediting_965153(17571637, +), ADediting_965154(17571638, +), ADediting_965155(17571687, +), ADediting_965156(17571704, +), ADediting_965157(17571705, +), ADediting_965158(17571710, +), ADediting_965159(17571712, +), ADediting_965160(17571871, +), ADediting_965161(17572067, +), ADediting_965162(17572322, +), ADediting_965163(17572364, +), ADediting_965164(17572365, +), ADediting_965165(17572378, +), ADediting_965166(17572863, +), ADediting_965167(17572992, +), ADediting_965168(17573006, +), ADediting_965169(17573528, +), ADediting_965170(17573974, +), ADediting_965171(17574020, +), ADediting_965172(17574046, +), ADediting_965173(17574111, +), ADediting_965174(17574163, +), ADediting_965175(17574166, +), ADediting_965176(17574565, +), ADediting_965177(17574573, +), ADediting_965178(17574603, +), ADediting_965179(17574634, +), ADediting_965180(17574705, +), ADediting_965181(17574744, +), ADediting_965182(17574763, +), ADediting_965183(17574922, +), ADediting_965184(17575035, +), ADediting_965185(17575049, +), ADediting_965186(17575054, +), ADediting_965187(17575066, +), ADediting_965188(17575072, +), ADediting_965189(17575095, +), ADediting_965190(17576098, +), ADediting_965191(17576099, +), ADediting_965192(17576104, +), ADediting_965193(17576165, +), ADediting_965194(17576168, +), ADediting_965195(17576196, +), ADediting_965196(17576205, +), ADediting_965197(17576231, +), ADediting_965198(17576299, +), ADediting_965199(17576304, +), ADediting_965200(17576985, +), ADediting_965201(17577720, +), ADediting_965202(17578233, +), ADediting_965203(17578744, +), ADediting_965204(17578779, +), ADediting_965205(17578780, +), ADediting_965206(17578801, +), ADediting_965207(17579167, +), ADediting_965208(17579190, +), ADediting_965209(17579193, +), ADediting_965210(17579194, +), ADediting_965211(17579201, +), ADediting_965212(17579228, +), ADediting_965213(17589261, +), ADediting_965214(17589280, +), ADediting_965215(17589281, +), ADediting_965216(17589298, +), ADediting_965217(17589310, +), ADediting_965218(17589320, +), ADediting_965219(17589358, +), ADediting_965220(17589361, +), ADediting_965221(17589378, +), ADediting_965222(17589387, +), ADediting_965223(17589438, +), ADediting_965224(17589450, +), ADediting_965225(17589459, +),

Top

RNA editing positional annotations for SLC25A18 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_965145chr22_17570516_+intronic
ADediting_965146chr22_17570546_+intronic
ADediting_965147chr22_17570624_+intronic
ADediting_965148chr22_17570754_+intronic
ADediting_965149chr22_17570760_+intronic
ADediting_965150chr22_17571549_+intronic
ADediting_965151chr22_17571573_+intronic
ADediting_965152chr22_17571611_+intronic
ADediting_965153chr22_17571637_+intronic
ADediting_965154chr22_17571638_+intronic
ADediting_965155chr22_17571687_+intronic
ADediting_965156chr22_17571704_+intronic
ADediting_965157chr22_17571705_+intronic
ADediting_965158chr22_17571710_+intronic
ADediting_965159chr22_17571712_+intronic
ADediting_965160chr22_17571871_+intronic
ADediting_965161chr22_17572067_+intronic
ADediting_965162chr22_17572322_+intronic
ADediting_965163chr22_17572364_+intronic
ADediting_965164chr22_17572365_+intronic
ADediting_965165chr22_17572378_+intronic
ADediting_965166chr22_17572863_+intronic
ADediting_965167chr22_17572992_+intronic
ADediting_965168chr22_17573006_+intronic
ADediting_965169chr22_17573528_+intronic
ADediting_965170chr22_17573974_+intronic
ADediting_965171chr22_17574020_+intronic
ADediting_965172chr22_17574046_+intronic
ADediting_965173chr22_17574111_+intronic
ADediting_965174chr22_17574163_+intronic
ADediting_965175chr22_17574166_+intronic
ADediting_965176chr22_17574565_+intronic
ADediting_965177chr22_17574573_+intronic
ADediting_965178chr22_17574603_+intronic
ADediting_965179chr22_17574634_+intronic
ADediting_965180chr22_17574705_+intronic
ADediting_965181chr22_17574744_+intronic
ADediting_965182chr22_17574763_+intronic
ADediting_965183chr22_17574922_+intronic
ADediting_965184chr22_17575035_+intronic
ADediting_965185chr22_17575049_+intronic
ADediting_965186chr22_17575054_+intronic
ADediting_965187chr22_17575066_+intronic
ADediting_965188chr22_17575072_+intronic
ADediting_965189chr22_17575095_+intronic
ADediting_965190chr22_17576098_+intronic
ADediting_965191chr22_17576099_+intronic
ADediting_965192chr22_17576104_+intronic
ADediting_965193chr22_17576165_+intronic
ADediting_965194chr22_17576168_+intronic
ADediting_965195chr22_17576196_+intronic
ADediting_965196chr22_17576205_+intronic
ADediting_965197chr22_17576231_+intronic
ADediting_965198chr22_17576299_+intronic
ADediting_965199chr22_17576304_+intronic
ADediting_965200chr22_17576985_+intronic
ADediting_965201chr22_17577720_+intronic
ADediting_965202chr22_17578233_+intronic
ADediting_965203chr22_17578744_+intronic
ADediting_965204chr22_17578779_+intronic
ADediting_965205chr22_17578780_+intronic
ADediting_965206chr22_17578801_+intronic
ADediting_965207chr22_17579167_+intronic
ADediting_965208chr22_17579190_+intronic
ADediting_965209chr22_17579193_+intronic
ADediting_965210chr22_17579194_+intronic
ADediting_965211chr22_17579201_+intronic
ADediting_965212chr22_17579228_+intronic
ADediting_965213chr22_17589261_+intronic
ADediting_965214chr22_17589280_+intronic
ADediting_965215chr22_17589281_+intronic
ADediting_965216chr22_17589298_+intronic
ADediting_965217chr22_17589310_+intronic
ADediting_965218chr22_17589320_+intronic
ADediting_965219chr22_17589358_+intronic
ADediting_965220chr22_17589361_+intronic
ADediting_965221chr22_17589378_+intronic
ADediting_965222chr22_17589387_+intronic
ADediting_965223chr22_17589438_+intronic
ADediting_965224chr22_17589450_+intronic
ADediting_965225chr22_17589459_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_965145chr22_17570516_+SINEAluName=AluSx
ADediting_965146chr22_17570546_+SINEAluName=AluSx
ADediting_965147chr22_17570624_+SINEAluName=AluSx
ADediting_965148chr22_17570754_+SINEAluName=AluSx
ADediting_965149chr22_17570760_+SINEAluName=AluSx
ADediting_965150chr22_17571549_+SINEAluName=AluSz6
ADediting_965151chr22_17571573_+SINEAluName=AluSz6
ADediting_965152chr22_17571611_+SINEAluName=AluSz6
ADediting_965153chr22_17571637_+SINEAluName=AluSz6
ADediting_965154chr22_17571638_+SINEAluName=AluSz6
ADediting_965155chr22_17571687_+SINEAluName=AluSz6
ADediting_965156chr22_17571704_+SINEAluName=AluSz6
ADediting_965157chr22_17571705_+SINEAluName=AluSz6
ADediting_965158chr22_17571710_+SINEAluName=AluSz6
ADediting_965159chr22_17571712_+SINEAluName=AluSz6
ADediting_965160chr22_17571871_+SINEAluName=AluSz
ADediting_965161chr22_17572067_+SINEAluName=AluSx
ADediting_965162chr22_17572322_+SINEAluName=AluSp
ADediting_965163chr22_17572364_+SINEAluName=AluSp
ADediting_965164chr22_17572365_+SINEAluName=AluSp
ADediting_965165chr22_17572378_+SINEAluName=AluSp
ADediting_965166chr22_17572863_+SINEAluName=AluY
ADediting_965167chr22_17572992_+SINEAluName=AluJr
ADediting_965168chr22_17573006_+SINEAluName=AluJr
ADediting_965170chr22_17573974_+SINEAluName=AluJb
ADediting_965171chr22_17574020_+SINEAluName=AluJb
ADediting_965172chr22_17574046_+SINEAluName=AluJb
ADediting_965173chr22_17574111_+SINEAluName=AluJb
ADediting_965174chr22_17574163_+SINEAluName=AluJb
ADediting_965175chr22_17574166_+SINEAluName=AluJb
ADediting_965176chr22_17574565_+SINEAluName=AluSg
ADediting_965177chr22_17574573_+SINEAluName=AluSg
ADediting_965178chr22_17574603_+SINEAluName=AluSg
ADediting_965179chr22_17574634_+SINEAluName=AluSg
ADediting_965180chr22_17574705_+SINEAluName=AluSg
ADediting_965181chr22_17574744_+SINEAluName=AluSg
ADediting_965182chr22_17574763_+SINEAluName=AluSg
ADediting_965183chr22_17574922_+SINEAluName=AluSx
ADediting_965184chr22_17575035_+SINEAluName=AluSx
ADediting_965185chr22_17575049_+SINEAluName=AluSx
ADediting_965186chr22_17575054_+SINEAluName=AluSx
ADediting_965187chr22_17575066_+SINEAluName=AluSx
ADediting_965188chr22_17575072_+SINEAluName=AluSx
ADediting_965189chr22_17575095_+SINEAluName=AluSx
ADediting_965190chr22_17576098_+SINEAluName=AluSc
ADediting_965191chr22_17576099_+SINEAluName=AluSc
ADediting_965192chr22_17576104_+SINEAluName=AluSc
ADediting_965193chr22_17576165_+SINEAluName=AluSc
ADediting_965194chr22_17576168_+SINEAluName=AluSc
ADediting_965195chr22_17576196_+SINEAluName=AluSc
ADediting_965196chr22_17576205_+SINEAluName=AluSc
ADediting_965197chr22_17576231_+SINEAluName=AluSc
ADediting_965198chr22_17576299_+SINEAluName=AluSc
ADediting_965199chr22_17576304_+SINEAluName=AluSc
ADediting_965200chr22_17576985_+SINEAluName=AluSx1
ADediting_965201chr22_17577720_+SINEAluName=AluSg
ADediting_965202chr22_17578233_+SINEAluName=AluJb
ADediting_965203chr22_17578744_+SINEAluName=AluSp
ADediting_965204chr22_17578779_+SINEAluName=AluSp
ADediting_965205chr22_17578780_+SINEAluName=AluSp
ADediting_965206chr22_17578801_+SINEAluName=AluSp
ADediting_965207chr22_17579167_+SINEAluName=AluSx1
ADediting_965208chr22_17579190_+SINEAluName=AluSx1
ADediting_965209chr22_17579193_+SINEAluName=AluSx1
ADediting_965210chr22_17579194_+SINEAluName=AluSx1
ADediting_965211chr22_17579201_+SINEAluName=AluSx1
ADediting_965212chr22_17579228_+SINEAluName=AluSx1
ADediting_965213chr22_17589261_+SINEAluName=AluSg
ADediting_965214chr22_17589280_+SINEAluName=AluSg
ADediting_965215chr22_17589281_+SINEAluName=AluSg
ADediting_965216chr22_17589298_+SINEAluName=AluSg
ADediting_965217chr22_17589310_+SINEAluName=AluSg
ADediting_965218chr22_17589320_+SINEAluName=AluSg
ADediting_965219chr22_17589358_+SINEAluName=AluSg
ADediting_965220chr22_17589361_+SINEAluName=AluSg
ADediting_965221chr22_17589378_+SINEAluName=AluSg
ADediting_965222chr22_17589387_+SINEAluName=AluSg
ADediting_965223chr22_17589438_+SINEAluName=AluSg
ADediting_965224chr22_17589450_+SINEAluName=AluSg
ADediting_965225chr22_17589459_+SINEAluName=AluSg

Top

RNA A-to-I editing events in the alternative splicing sites for SLC25A18

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC25A18

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
Soverview
Soverview
Soverview
Soverview

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

Top

Protein coding region RNA A-to-I editings for SLC25A18

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for SLC25A18


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for SLC25A18

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for SLC25A18

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_965156chr22_17571704_+0.9643210488746060.002550899077912940.112944000994043-0.09020831713062511.66291504891818e-080.313689363489393
DLPFCADediting_965161chr22_17572067_+0.4602601818936830.04209079888462750.53260386025973-0.0355753649256048.56880738079955e-110.357793242184804
DLPFCADediting_965164chr22_17572365_+0.602419403848578-0.02969997338185750.0516824707812951-0.1106197578159851.22694587172472e-100.354997813836177
DLPFCADediting_965167chr22_17572992_+0.5325430344461010.03558064191961780.407372167464876-0.04722167286258651.12547732929644e-170.460469785605055
DLPFCADediting_965174chr22_17574163_+0.06668314791630130.1042901709120350.287534188586606-0.06059464786136737.20293467720608e-260.549642851315555
DLPFCADediting_965175chr22_17574166_+0.5257750588467950.03616971799254970.187875105508957-0.07499198375164451.10073063110268e-160.447682603495092
DLPFCADediting_965176chr22_17574565_+0.1277728231798940.08668467595192830.515812465801503-0.03704392585473773.85930393431817e-110.363908753983532
DLPFCADediting_965178chr22_17574603_+0.03667684162163570.1187263190614480.8230058367131050.01275521595083289.33554481924725e-090.318879894753029
DLPFCADediting_965181chr22_17574744_+0.9578453697777810.00301427993148310.446621237590025-0.0433801958970451.61715557029361e-080.313942530765626
DLPFCADediting_965186chr22_17575054_+0.1491078644152080.08213257643203040.542013590942591-0.03476262233982581.94390064209785e-170.457453838709384
DLPFCADediting_965187chr22_17575066_+0.2203886282944210.06980051533744240.195429872881591-0.0737307425341631.16608173083541e-160.447352124654616
DLPFCADediting_965188chr22_17575072_+0.3804689141879630.04998288279071690.163050889969153-0.07941972083105128.49534111757651e-140.406991830449237
DLPFCADediting_965199chr22_17576304_+0.2387006814949180.06711522284604880.576211940423899-0.03186555337714747.29490227796436e-140.407988427599814
DLPFCADediting_965205chr22_17578780_+0.02968956401483270.1235124440931860.809624337986481-0.01373765874262434.40377890703018e-140.411266671674438
DLPFCADediting_965206chr22_17578801_+0.1999987403703590.07298517534609620.292242018552316-0.06000714140776483.42745779933556e-140.412881444196906

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC0.00122298182452530.1828366407548210.08663462988061650.09747783176902371.61776430792999e-300.590482667006149
AC2.92437294754804e-270.6136639134950081.8775800967148e-150.4746738607014953.83585323468756e-260.602989171722618
PCC0.002946175604840760.2140463389953310.03569060780237890.1520951861244891.54065730473621e-070.368665321525687
CER0.470429965723201-0.05937775762063190.0552505447279188-0.1568562067622483.49214975996707e-080.43163596318376
FP6.02767262637971e-050.296010245311840.01061256810559380.1910986021070542.31329360970414e-180.594076837015103
IFG0.009530795083471050.50797143000660.002029380651684280.5871885181707060.02555919091098890.445683069701493
PG0.004448538756072990.2076876544142160.2567211506386760.08357958667956281.37063354523056e-080.401331769280811
STG0.003230907753042010.3177031572797450.3087675582147560.1123839951467612.6043125748973e-090.593903888007771

Top

Relation with AD stages for SLC25A18

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
TCXADediting_965215chr22_17589281_+0.0004312485981317560.335902639036526

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX5.94869534595201e-080.497096554061174
PG1.30373602702026e-050.313662688612015

Top

RelatedDrugs for SLC25A18

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
SLC25A18Q9H1K4DB00142Glutamic AcidMitochondrial glutamate carrier 2small moleculeapproved|nutraceutical

Top

RelatedDiseases for SLC25A18

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource