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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for PLA2G12A

check button Gene summary
Gene informationGene symbol

PLA2G12A

Gene ID

81579

Gene namephospholipase A2 group XIIA
SynonymsGXII|PLA2G12|ROSSY
Cytomap

4q25

Type of geneprotein-coding
Descriptiongroup XIIA secretory phospholipase A2GXII sPLA2group XII secreted phospholipase A2group XIIA secreted phospholipase A2phosphatidylcholine 2-acylhydrolase 12Aphospholipase A2, group XIIsPLA2-XII
Modification date20200313
UniProtAcc

Q9BZM1,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for PLA2G12A

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1102628(109710554, -), ADediting_1102629(109710562, -), ADediting_1102630(109710563, -), ADediting_1102631(109710574, -), ADediting_1102632(109710603, -), ADediting_1102633(109710604, -), ADediting_1102634(109710630, -), ADediting_1102635(109710644, -), ADediting_1102636(109710659, -), ADediting_1102637(109710669, -), ADediting_1102638(109710738, -), ADediting_1102639(109710746, -), ADediting_1102640(109712617, -), ADediting_1102641(109712635, -), ADediting_1102642(109712768, -), ADediting_1102643(109712769, -), ADediting_1102644(109712771, -), ADediting_1102645(109720812, -), ADediting_1102646(109720834, -), ADediting_1102647(109720903, -), ADediting_1102648(109720906, -), ADediting_1102649(109720910, -), ADediting_1102650(109720959, -), ADediting_1102651(109720962, -), ADediting_1102652(109720988, -), ADediting_1102653(109720995, -), ADediting_1102654(109721008, -), ADediting_1102655(109721011, -), ADediting_1102656(109721066, -), ADediting_1102657(109721154, -), ADediting_1102658(109721285, -), ADediting_1102659(109721389, -), ADediting_1102660(109721390, -), ADediting_1102661(109721394, -), ADediting_1102662(109721397, -), ADediting_1102663(109721407, -), ADediting_1102664(109721414, -), ADediting_1102665(109721418, -), ADediting_1102666(109721424, -), ADediting_1102667(109721433, -), ADediting_1102668(109721442, -), ADediting_1102669(109721450, -), ADediting_1102670(109721454, -), ADediting_1102671(109721459, -), ADediting_1102672(109721482, -), ADediting_1102673(109721486, -), ADediting_1102674(109721495, -), ADediting_1102675(109721498, -), ADediting_1102676(109721504, -), ADediting_1102677(109721516, -), ADediting_1102678(109721525, -), ADediting_1102679(109721535, -), ADediting_1102680(109721549, -), ADediting_1102681(109721586, -), ADediting_1102682(109721587, -), ADediting_1102683(109721592, -), ADediting_1102684(109721593, -), ADediting_1102685(109721611, -), ADediting_1102686(109727207, -), ADediting_1102687(109727208, -), ADediting_1102688(109727214, -), ADediting_1102689(109727216, -), ADediting_1102690(109727243, -), ADediting_1102691(109727249, -), ADediting_1102692(109727383, -), ADediting_1102693(109727685, -), ADediting_1576118(109712675, -), ADediting_1576119(109719436, -), ADediting_1649698(109710582, -), ADediting_1649699(109710661, -), ADediting_1649700(109710747, -), ADediting_1649701(109727714, -), ADediting_1649702(109727715, -), ADediting_1649703(109727718, -), ADediting_1649704(109727770, -), ADediting_1649705(109727793, -),

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RNA editing positional annotations for PLA2G12A using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1102628chr4_109710554_-UTR3
ADediting_1102629chr4_109710562_-UTR3
ADediting_1102630chr4_109710563_-UTR3
ADediting_1102631chr4_109710574_-UTR3
ADediting_1102632chr4_109710603_-UTR3
ADediting_1102633chr4_109710604_-UTR3
ADediting_1102634chr4_109710630_-UTR3
ADediting_1102635chr4_109710644_-UTR3
ADediting_1102636chr4_109710659_-UTR3
ADediting_1102637chr4_109710669_-UTR3
ADediting_1102638chr4_109710738_-UTR3
ADediting_1102639chr4_109710746_-UTR3
ADediting_1102640chr4_109712617_-UTR3
ADediting_1102641chr4_109712635_-UTR3
ADediting_1102642chr4_109712768_-UTR3
ADediting_1102643chr4_109712769_-UTR3
ADediting_1102644chr4_109712771_-UTR3
ADediting_1102645chr4_109720812_-intronic
ADediting_1102646chr4_109720834_-intronic
ADediting_1102647chr4_109720903_-intronic
ADediting_1102648chr4_109720906_-intronic
ADediting_1102649chr4_109720910_-intronic
ADediting_1102650chr4_109720959_-intronic
ADediting_1102651chr4_109720962_-intronic
ADediting_1102652chr4_109720988_-intronic
ADediting_1102653chr4_109720995_-intronic
ADediting_1102654chr4_109721008_-intronic
ADediting_1102655chr4_109721011_-intronic
ADediting_1102656chr4_109721066_-intronic
ADediting_1102657chr4_109721154_-intronic
ADediting_1102658chr4_109721285_-intronic
ADediting_1102659chr4_109721389_-intronic
ADediting_1102660chr4_109721390_-intronic
ADediting_1102661chr4_109721394_-intronic
ADediting_1102662chr4_109721397_-intronic
ADediting_1102663chr4_109721407_-intronic
ADediting_1102664chr4_109721414_-intronic
ADediting_1102665chr4_109721418_-intronic
ADediting_1102666chr4_109721424_-intronic
ADediting_1102667chr4_109721433_-intronic
ADediting_1102668chr4_109721442_-intronic
ADediting_1102669chr4_109721450_-intronic
ADediting_1102670chr4_109721454_-intronic
ADediting_1102671chr4_109721459_-intronic
ADediting_1102672chr4_109721482_-intronic
ADediting_1102673chr4_109721486_-intronic
ADediting_1102674chr4_109721495_-intronic
ADediting_1102675chr4_109721498_-intronic
ADediting_1102676chr4_109721504_-intronic
ADediting_1102677chr4_109721516_-intronic
ADediting_1102678chr4_109721525_-intronic
ADediting_1102679chr4_109721535_-intronic
ADediting_1102680chr4_109721549_-intronic
ADediting_1102681chr4_109721586_-intronic
ADediting_1102682chr4_109721587_-intronic
ADediting_1102683chr4_109721592_-intronic
ADediting_1102684chr4_109721593_-intronic
ADediting_1102685chr4_109721611_-intronic
ADediting_1102686chr4_109727207_-intronic
ADediting_1102687chr4_109727208_-intronic
ADediting_1102688chr4_109727214_-intronic
ADediting_1102689chr4_109727216_-intronic
ADediting_1102690chr4_109727243_-intronic
ADediting_1102691chr4_109727249_-intronic
ADediting_1102692chr4_109727383_-intronic
ADediting_1102693chr4_109727685_-intronic
ADediting_1576118chr4_109712675_-UTR3
ADediting_1576119chr4_109719436_-intronic
ADediting_1649698chr4_109710582_-UTR3
ADediting_1649699chr4_109710661_-UTR3
ADediting_1649700chr4_109710747_-UTR3
ADediting_1649701chr4_109727714_-intronic
ADediting_1649702chr4_109727715_-intronic
ADediting_1649703chr4_109727718_-intronic
ADediting_1649704chr4_109727770_-intronic
ADediting_1649705chr4_109727793_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1102628chr4_109710554_-SINEAluName=AluSz6
ADediting_1102629chr4_109710562_-SINEAluName=AluSz6
ADediting_1102630chr4_109710563_-SINEAluName=AluSz6
ADediting_1102631chr4_109710574_-SINEAluName=AluSz6
ADediting_1102632chr4_109710603_-SINEAluName=AluSz6
ADediting_1102633chr4_109710604_-SINEAluName=AluSz6
ADediting_1102634chr4_109710630_-SINEAluName=AluSz6
ADediting_1102635chr4_109710644_-SINEAluName=AluSz6
ADediting_1102636chr4_109710659_-SINEAluName=AluSz6
ADediting_1102637chr4_109710669_-SINEAluName=AluSz6
ADediting_1102638chr4_109710738_-SINEAluName=AluSz6
ADediting_1102639chr4_109710746_-SINEAluName=AluSz6
ADediting_1102640chr4_109712617_-SINEAluName=AluSz
ADediting_1102641chr4_109712635_-SINEAluName=AluSz
ADediting_1102642chr4_109712768_-SINEAluName=AluSz
ADediting_1102643chr4_109712769_-SINEAluName=AluSz
ADediting_1102644chr4_109712771_-SINEAluName=AluSz
ADediting_1102645chr4_109720812_-SINEAluName=AluSp
ADediting_1102646chr4_109720834_-SINEAluName=AluSp
ADediting_1102647chr4_109720903_-SINEAluName=AluSp
ADediting_1102648chr4_109720906_-SINEAluName=AluSp
ADediting_1102649chr4_109720910_-SINEAluName=AluSp
ADediting_1102650chr4_109720959_-SINEAluName=AluSp
ADediting_1102651chr4_109720962_-SINEAluName=AluSp
ADediting_1102652chr4_109720988_-SINEAluName=AluSp
ADediting_1102653chr4_109720995_-SINEAluName=AluSp
ADediting_1102654chr4_109721008_-SINEAluName=AluSp
ADediting_1102655chr4_109721011_-SINEAluName=AluSp
ADediting_1102656chr4_109721066_-SINEAluName=AluSp
ADediting_1102659chr4_109721389_-SINEAluName=AluSg
ADediting_1102660chr4_109721390_-SINEAluName=AluSg
ADediting_1102661chr4_109721394_-SINEAluName=AluSg
ADediting_1102662chr4_109721397_-SINEAluName=AluSg
ADediting_1102663chr4_109721407_-SINEAluName=AluSg
ADediting_1102664chr4_109721414_-SINEAluName=AluSg
ADediting_1102665chr4_109721418_-SINEAluName=AluSg
ADediting_1102666chr4_109721424_-SINEAluName=AluSg
ADediting_1102667chr4_109721433_-SINEAluName=AluSg
ADediting_1102668chr4_109721442_-SINEAluName=AluSg
ADediting_1102669chr4_109721450_-SINEAluName=AluSg
ADediting_1102670chr4_109721454_-SINEAluName=AluSg
ADediting_1102671chr4_109721459_-SINEAluName=AluSg
ADediting_1102672chr4_109721482_-SINEAluName=AluSg
ADediting_1102673chr4_109721486_-SINEAluName=AluSg
ADediting_1102674chr4_109721495_-SINEAluName=AluSg
ADediting_1102675chr4_109721498_-SINEAluName=AluSg
ADediting_1102676chr4_109721504_-SINEAluName=AluSg
ADediting_1102677chr4_109721516_-SINEAluName=AluSg
ADediting_1102678chr4_109721525_-SINEAluName=AluSg
ADediting_1102679chr4_109721535_-SINEAluName=AluSg
ADediting_1102680chr4_109721549_-SINEAluName=AluSg
ADediting_1102681chr4_109721586_-SINEAluName=AluSg
ADediting_1102682chr4_109721587_-SINEAluName=AluSg
ADediting_1102683chr4_109721592_-SINEAluName=AluSg
ADediting_1102684chr4_109721593_-SINEAluName=AluSg
ADediting_1102685chr4_109721611_-SINEAluName=AluSg
ADediting_1102686chr4_109727207_-SINEAluName=AluSz
ADediting_1102687chr4_109727208_-SINEAluName=AluSz
ADediting_1102688chr4_109727214_-SINEAluName=AluSz
ADediting_1102689chr4_109727216_-SINEAluName=AluSz
ADediting_1102690chr4_109727243_-SINEAluName=AluSz
ADediting_1102691chr4_109727249_-SINEAluName=AluSz
ADediting_1102692chr4_109727383_-SINEAluName=AluSz
ADediting_1102693chr4_109727685_-SINEAluName=AluJo
ADediting_1576118chr4_109712675_-SINEAluName=AluSz
ADediting_1649698chr4_109710582_-SINEAluName=AluSz6
ADediting_1649699chr4_109710661_-SINEAluName=AluSz6
ADediting_1649700chr4_109710747_-SINEAluName=AluSz6
ADediting_1649701chr4_109727714_-SINEAluName=AluJo
ADediting_1649702chr4_109727715_-SINEAluName=AluJo
ADediting_1649703chr4_109727718_-SINEAluName=AluJo
ADediting_1649704chr4_109727770_-SINEAluName=AluJo
ADediting_1649705chr4_109727793_-SINEAluName=AluJo

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RNA A-to-I editing events in the alternative splicing sites for PLA2G12A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PLA2G12A

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for PLA2G12A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PLA2G12A

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1102628chr4_109710554_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-5001-3pchr41097105491097105557mer-m8109710548109710566160-26.2
ADediting_1102628chr4_109710554_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6778-3pchr41097105511097105588mer-1a109710551109710569148-20.3
ADediting_1102628chr4_109710554_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6836-3pchr41097105511097105577mer-m8109710550109710570145-20.71
ADediting_1102629chr4_109710562_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-3155achr41097105581097105647mer-m8109710557109710578145-20.35
ADediting_1102629chr4_109710562_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-3155bchr41097105581097105647mer-m8109710557109710575145-20.01
ADediting_1102629chr4_109710562_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-484chr41097105581097105647mer-m8109710557109710578153-20.77
ADediting_1102630chr4_109710563_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-9900chr41097105581097105647mer-m8109710557109710576143-13.99
ADediting_1102631chr4_109710574_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-1914-5pchr41097105721097105798mer-1a109710572109710590148-23.27
ADediting_1102631chr4_109710574_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-7152-5pchr41097105711097105777mer-m8109710570109710592155-20.1
ADediting_1102632chr4_109710603_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-8052chr41097105981097106047mer-1a109710598109710616143-23.77
ADediting_1102633chr4_109710604_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-513a-5pchr41097106031097106097mer-m8109710602109710619160-21.48
ADediting_1102633chr4_109710604_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-638chr41097105981097106047mer-1a109710598109710622163-35.62
ADediting_1102635chr4_109710644_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-325chr41097106431097106508mer-1a109710643109710665141-13.99
ADediting_1102636chr4_109710659_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-1251-3pchr41097106581097106647mer-m8109710657109710677141-14.37
ADediting_1102636chr4_109710659_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-3158-3pchr41097106551097106617mer-m8109710654109710674142-17.09
ADediting_1102637chr4_109710669_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-3190-5pchr41097106691097106757mer-m8109710668109710687151-19.64
ADediting_1102638chr4_109710738_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-3672chr41097107331097107397mer-m8109710732109710757155-14.35
ADediting_1102638chr4_109710738_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6864-3pchr41097107331097107397mer-m8109710732109710752142-10.4
ADediting_1102639chr4_109710746_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4650-5pchr41097107411097107477mer-m8109710740109710757143-20.55
ADediting_1102640chr4_109712617_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-660-3pchr41097126161097126227mer-m8109712615109712636154-23.09
ADediting_1102640chr4_109712617_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6791-3pchr41097126151097126217mer-m8109712614109712634150-17.2
ADediting_1102640chr4_109712617_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6829-3pchr41097126151097126217mer-m8109712614109712633155-20.58
ADediting_1102641chr4_109712635_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4786-5pchr41097126291097126368mer-1a109712629109712648152-22.4
ADediting_1102641chr4_109712635_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6502-3pchr41097126311097126377mer-m8109712630109712650140-10.93
ADediting_1102642chr4_109712768_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-625-3pchr41097127671097127737mer-m8109712766109712787144-12.62
ADediting_1102643chr4_109712769_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-638chr41097127631097127697mer-1a109712763109712787141-24.95
ADediting_1102644chr4_109712771_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-10399-5pchr41097127671097127737mer-m8109712766109712787148-10
ADediting_1102644chr4_109712771_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-3934-5pchr41097127711097127777mer-m8109712770109712792159-25.59
ADediting_1102644chr4_109712771_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-552-3pchr41097127691097127768mer-1a109712769109712789140-14.1
ADediting_1102644chr4_109712771_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6504-3pchr41097127671097127737mer-m8109712766109712787149-15.11
ADediting_1576118chr4_109712675_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-325chr41097126741097126818mer-1a109712674109712696149-11.53
ADediting_1649698chr4_109710582_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6836-3pchr41097105771097105837mer-m8109710576109710596151-26.57
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-152-5pchr41097106571097106637mer-m8109710656109710678149-16.7
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4727-5pchr41097106591097106668mer-1a109710659109710680148-15.4
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4769-3pchr41097106601097106678mer-1a109710660109710681140-13.73
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6738-3pchr41097106591097106657mer-m8109710658109710682141-13.97
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6817-5pchr41097106601097106678mer-1a109710660109710687148-23.97

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1102631chr4_109710574_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-578chr41097105711097105777mer-m8109710570109710590153-13.53
ADediting_1102632chr4_109710603_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-10399-5pchr41097106021097106087mer-m8109710601109710622152-11.75
ADediting_1102632chr4_109710603_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-5089-5pchr41097105981097106047mer-m8109710597109710616146-12.33
ADediting_1102632chr4_109710603_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6504-3pchr41097106021097106087mer-m8109710601109710622148-14.2
ADediting_1102633chr4_109710604_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-10399-5pchr41097106021097106087mer-m8109710601109710622152-11.75
ADediting_1102633chr4_109710604_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6504-3pchr41097106021097106087mer-m8109710601109710622148-14.2
ADediting_1102633chr4_109710604_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-7151-3pchr41097106031097106108mer-1a109710603109710619142-13.26
ADediting_1102634chr4_109710630_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-3129-3pchr41097106271097106337mer-m8109710626109710647145-4.24
ADediting_1102634chr4_109710630_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4735-5pchr41097106291097106357mer-m8109710628109710649140-5.43
ADediting_1102634chr4_109710630_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-5583-5pchr41097106271097106337mer-m8109710626109710647147-4.54
ADediting_1102636chr4_109710659_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-19a-5pchr41097106581097106647mer-m8109710657109710678153-12.12
ADediting_1102636chr4_109710659_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-19b-1-5pchr41097106581097106647mer-m8109710657109710680155-14.94
ADediting_1102636chr4_109710659_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-19b-2-5pchr41097106581097106647mer-m8109710657109710679155-12.76
ADediting_1102636chr4_109710659_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6823-5pchr41097106541097106607mer-m8109710653109710673143-17.48
ADediting_1102637chr4_109710669_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4716-5pchr41097106641097106707mer-m8109710663109710684140-10.69
ADediting_1102637chr4_109710669_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4781-3pchr41097106661097106727mer-m8109710665109710683144-13.79
ADediting_1102638chr4_109710738_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-10399-5pchr41097107371097107437mer-m8109710736109710757148-11.66
ADediting_1102638chr4_109710738_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-6504-3pchr41097107371097107437mer-m8109710736109710757144-12.32
ADediting_1102640chr4_109712617_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-516a-3pchr41097126151097126217mer-m8109712614109712631140-13.02
ADediting_1102640chr4_109712617_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-516b-3pchr41097126151097126217mer-m8109712614109712631140-13.02
ADediting_1102640chr4_109712617_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-7162-5pchr41097126151097126217mer-m8109712614109712630142-16.14
ADediting_1102642chr4_109712768_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-5089-5pchr41097127631097127697mer-m8109712762109712784148-13.1
ADediting_1649698chr4_109710582_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-412-3pchr41097105801097105867mer-m8109710579109710600150-16.42
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-19a-5pchr41097106581097106647mer-m8109710657109710678153-12.12
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-19b-1-5pchr41097106581097106647mer-m8109710657109710680155-14.94
ADediting_1649699chr4_109710661_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-19b-2-5pchr41097106581097106647mer-m8109710657109710679155-12.76

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-5688chr41097119521097119587mer-m8109711951109711972142-11.27
ADediting_1471003chr9_63819626_+ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4477bchr41097119641097119707mer-m8109711963109711986147-11.16
ADediting_286380chr11_79422188_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-5579-3pchr41097128181097128247mer-m8109712817109712841155-16.53
ADediting_843620chr2_207754818_+ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4775chr41097123561097123627mer-m8109712355109712381149-13.56
ADediting_98288chr1_32086990_+ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-5585-3pchr41097136341097136407mer-m8109713633109713654150-16.61

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-589-3pchr41097130271097130337mer-m8109713026109713052144-21.17
ADediting_1556067chr19_40282625_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-641chr41097141301097141367mer-m8109714129109714156149-10.51
ADediting_1556067chr19_40282625_-ENSG00000123739.11ENST00000502283.1PLA2G12A-202hsa-miR-641chr41097141301097141367mer-m8109714129109714156149-10.51
ADediting_1631458chr19_40282624_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-641chr41097141301097141367mer-m8109714129109714156149-10.51
ADediting_1631458chr19_40282624_-ENSG00000123739.11ENST00000502283.1PLA2G12A-202hsa-miR-641chr41097141301097141367mer-m8109714129109714156149-10.51
ADediting_291761chr11_93733708_-ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-1304-3pchr41097129351097129428mer-1a109712935109712958151-20.74
ADediting_843620chr2_207754818_+ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4775chr41097107751097107817mer-m8109710774109710795140-4.68
ADediting_843620chr2_207754818_+ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4775chr41097117801097117867mer-m8109711779109711800145-4.78
ADediting_843620chr2_207754818_+ENSG00000123739.11ENST00000243501.10PLA2G12A-201hsa-miR-4775chr41097133281097133347mer-m8109713327109713348152-3.33

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PLA2G12A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000243501.10protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1102628ENST00000243501.10chr4_109710554_-4654-1473.10-1473.10-1493.30
ADediting_1102629ENST00000243501.10chr4_109710562_-4646-1473.10-1473.10-1493.30
ADediting_1102630ENST00000243501.10chr4_109710563_-4645-1476.10-1473.10-1493.30
ADediting_1102631ENST00000243501.10chr4_109710574_-4634-1475.00-1473.10-1493.30
ADediting_1649698ENST00000243501.10chr4_109710582_-4626-1474.80-1473.10-1493.30
ADediting_1102632ENST00000243501.10chr4_109710603_-4605-1473.10-1473.10-1493.30
ADediting_1102633ENST00000243501.10chr4_109710604_-4604-1473.10-1473.10-1493.30
ADediting_1102634ENST00000243501.10chr4_109710630_-4578-1475.50-1473.10-1493.30
ADediting_1102635ENST00000243501.10chr4_109710644_-4564-1473.10-1473.10-1493.30
ADediting_1102636ENST00000243501.10chr4_109710659_-4549-1478.20-1473.10-1493.30
ADediting_1649699ENST00000243501.10chr4_109710661_-4547-1475.90-1473.10-1493.30
ADediting_1102637ENST00000243501.10chr4_109710669_-4539-1474.50-1473.10-1493.30
ADediting_1102638ENST00000243501.10chr4_109710738_-4470-1474.10-1473.10-1493.30
ADediting_1102639ENST00000243501.10chr4_109710746_-4462-1474.40-1473.10-1493.30
ADediting_1649700ENST00000243501.10chr4_109710747_-4461-1474.10-1473.10-1493.30
ADediting_1102640ENST00000243501.10chr4_109712617_-2591-1473.10-1473.10-1493.30
ADediting_1102641ENST00000243501.10chr4_109712635_-2573-1473.10-1473.10-1493.30
ADediting_1576118ENST00000243501.10chr4_109712675_-2533-1473.80-1473.10-1493.30
ADediting_1102642ENST00000243501.10chr4_109712768_-2440-1473.10-1473.10-1493.30
ADediting_1102643ENST00000243501.10chr4_109712769_-2439-1474.50-1473.10-1493.30
ADediting_1102644ENST00000243501.10chr4_109712771_-2437-1476.10-1473.10-1493.30

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PLA2G12A

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_1102639chr4_109710746_-0.01966479799769640.1903106840726623.99272571347876e-060.3664325073939940.01775407033030870.193354629458465

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.08016572855571e-550.7431851440140931.34895649613773e-290.5828315232965415.50286022163477e-100.343004930632252
AC4.78907566116331e-470.7533684990615654.15160756468551e-360.6859815819971583.39499896534518e-110.403294238478037
PCC3.70658784883112e-170.5599657617969261.86119638518287e-140.5171696742103810.00299729743734650.213674793419331
CER1.12498360256347e-470.8716054682332731.78454942236741e-270.7418990452917010.004284137796027750.231978157448155
TCX1.83438200264051e-260.7321972795175510.0003330579691275510.289106491649712.49115615680161e-090.462747964696377
FP1.24273651839959e-160.5685837056280881.41932951481524e-110.4785288639385770.00118686246153220.24110326088598
IFG0.0001050959424155670.6978936202088220.002461058420299740.5783035917415030.7569477557369950.0651688614023896
PG2.43514179789075e-450.8143123215437954.04796189535565e-170.5656128288443010.2184224642960330.0906670023739324
STG8.46239199880204e-140.7035371199049911.20946165880618e-080.5732048352720270.1902622530553190.144324337135443

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Relation with AD stages for PLA2G12A

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.0004971594388348720.329508089729505
TCX1.02963177967533e-050.413947854745345

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RelatedDrugs for PLA2G12A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLA2G12A

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
PLA2G12AC0023893Liver Cirrhosis, Experimental1CTD_human