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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CAMK2A |
 Gene summary |
| Gene information | Gene symbol | CAMK2A | Gene ID | 815 |
| Gene name | calcium/calmodulin dependent protein kinase II alpha | |
| Synonyms | CAMKA|CaMKIINalpha|CaMKIIalpha|MRD53|MRT63 | |
| Cytomap | 5q32 | |
| Type of gene | protein-coding | |
| Description | calcium/calmodulin-dependent protein kinase type II subunit alphaCaM kinase II alpha subunitCaM-kinase II alpha chainCaMK-II alpha subunitcaM kinase II subunit alphacaMK-II subunit alphacalcium/calmodulin-dependent protein kinase (CaM kinase) II alp | |
| Modification date | 20200327 | |
| UniProtAcc | Q9UQM7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CAMK2A | GO:0006468 | protein phosphorylation | 17052756 |
| CAMK2A | GO:0038166 | angiotensin-activated signaling pathway | 20584908 |
Top |
RNA A-to-I events for CAMK2A |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1180495(150224904, -), ADediting_1180496(150224926, -), ADediting_1180497(150224935, -), ADediting_1180498(150224940, -), ADediting_1180499(150224957, -), ADediting_1180500(150224958, -), ADediting_1180501(150224969, -), ADediting_1180502(150224981, -), ADediting_1180503(150224995, -), ADediting_1180504(150225817, -), ADediting_1180505(150225818, -), ADediting_1180506(150225847, -), ADediting_1180507(150225866, -), ADediting_1180508(150225873, -), ADediting_1180509(150225883, -), ADediting_1180510(150225901, -), ADediting_1180511(150225905, -), ADediting_1180512(150225909, -), ADediting_1180513(150225912, -), ADediting_1180514(150225916, -), ADediting_1180515(150225918, -), ADediting_1180516(150225920, -), ADediting_1180517(150225923, -), ADediting_1180518(150225924, -), ADediting_1180519(150225933, -), ADediting_1180520(150225938, -), ADediting_1180521(150225939, -), ADediting_1180522(150225958, -), ADediting_1180523(150225963, -), ADediting_1180524(150225964, -), ADediting_1180525(150225972, -), ADediting_1180526(150225982, -), ADediting_1180527(150226002, -), ADediting_1180528(150226013, -), ADediting_1180529(150226018, -), ADediting_1180530(150226019, -), ADediting_1180531(150226027, -), ADediting_1180532(150226480, -), ADediting_1180533(150226492, -), ADediting_1180534(150226493, -), ADediting_1180535(150226520, -), ADediting_1180536(150226533, -), ADediting_1180537(150226574, -), ADediting_1180538(150226580, -), ADediting_1180539(150226582, -), ADediting_1180540(150226615, -), ADediting_1180541(150226637, -), ADediting_1180542(150226693, -), ADediting_1180543(150226864, -), ADediting_1180544(150226871, -), ADediting_1180545(150226909, -), ADediting_1180546(150226910, -), ADediting_1180547(150226936, -), ADediting_1180548(150226960, -), ADediting_1180549(150226965, -), ADediting_1180550(150226966, -), ADediting_1180551(150226967, -), ADediting_1180552(150227044, -), ADediting_1180553(150227045, -), ADediting_1180554(150227403, -), ADediting_1180555(150227947, -), ADediting_1180556(150228091, -), ADediting_1180557(150231843, -), ADediting_1180558(150233875, -), ADediting_1180559(150233937, -), ADediting_1180560(150234026, -), ADediting_1180561(150234063, -), ADediting_1180562(150234064, -), ADediting_1180563(150234069, -), ADediting_1180564(150234084, -), ADediting_1180565(150234090, -), ADediting_1180566(150236909, -), ADediting_1180567(150238176, -), ADediting_1180568(150238188, -), ADediting_1180569(150238194, -), ADediting_1180570(150238206, -), ADediting_1180571(150238207, -), ADediting_1180572(150238283, -), ADediting_1180573(150238285, -), ADediting_1180574(150238294, -), ADediting_1180575(150238370, -), ADediting_1180576(150238389, -), ADediting_1180577(150238408, -), ADediting_1180578(150253086, -), ADediting_1180579(150253089, -), ADediting_1180580(150253318, -), ADediting_1180581(150254322, -), ADediting_1180582(150254763, -), ADediting_1180583(150255499, -), ADediting_1180584(150255644, -), ADediting_1180585(150257986, -), ADediting_1180586(150260968, -), ADediting_1180587(150262329, -), ADediting_1180588(150262675, -), ADediting_1180589(150265683, -), ADediting_1180590(150265694, -), ADediting_1180591(150265716, -), ADediting_1180592(150265720, -), ADediting_1180593(150265779, -), ADediting_1180594(150265785, -), ADediting_1180595(150265820, -), ADediting_1180596(150265830, -), ADediting_1180597(150265883, -), ADediting_1180598(150265897, -), ADediting_1180599(150267903, -), ADediting_1180600(150267941, -), ADediting_1180601(150267972, -), ADediting_1180602(150268002, -), ADediting_1180603(150268006, -), ADediting_1180604(150268012, -), ADediting_1180605(150268038, -), ADediting_1180606(150268053, -), ADediting_1180607(150268054, -), ADediting_1180608(150268107, -), ADediting_1180609(150268128, -), ADediting_1180610(150268129, -), ADediting_1180611(150268145, -), ADediting_1180612(150268792, -), ADediting_1180613(150268806, -), ADediting_1180614(150268845, -), ADediting_1180615(150268852, -), ADediting_1180616(150268857, -), ADediting_1180617(150268892, -), ADediting_1180618(150268902, -), ADediting_1180619(150268920, -), ADediting_1180620(150268928, -), ADediting_1180621(150268984, -), ADediting_1180622(150269039, -), ADediting_1180623(150269506, -), ADediting_1180624(150269572, -), ADediting_1180625(150269635, -), ADediting_1180626(150270037, -), ADediting_1180627(150272373, -), ADediting_1180628(150272399, -), ADediting_1180629(150272402, -), ADediting_1180630(150272408, -), ADediting_1180631(150272423, -), ADediting_1180632(150272447, -), ADediting_1180633(150286637, -), ADediting_1655514(150234045, -), ADediting_1655515(150238208, -), ADediting_1655516(150271479, -), |
Top |
RNA editing positional annotations for CAMK2A using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1180495 | chr5_150224904_- | intronic |
| ADediting_1180496 | chr5_150224926_- | intronic |
| ADediting_1180497 | chr5_150224935_- | intronic |
| ADediting_1180498 | chr5_150224940_- | intronic |
| ADediting_1180499 | chr5_150224957_- | intronic |
| ADediting_1180500 | chr5_150224958_- | intronic |
| ADediting_1180501 | chr5_150224969_- | intronic |
| ADediting_1180502 | chr5_150224981_- | intronic |
| ADediting_1180503 | chr5_150224995_- | intronic |
| ADediting_1180504 | chr5_150225817_- | intronic |
| ADediting_1180505 | chr5_150225818_- | intronic |
| ADediting_1180506 | chr5_150225847_- | intronic |
| ADediting_1180507 | chr5_150225866_- | intronic |
| ADediting_1180508 | chr5_150225873_- | intronic |
| ADediting_1180509 | chr5_150225883_- | intronic |
| ADediting_1180510 | chr5_150225901_- | intronic |
| ADediting_1180511 | chr5_150225905_- | intronic |
| ADediting_1180512 | chr5_150225909_- | intronic |
| ADediting_1180513 | chr5_150225912_- | intronic |
| ADediting_1180514 | chr5_150225916_- | intronic |
| ADediting_1180515 | chr5_150225918_- | intronic |
| ADediting_1180516 | chr5_150225920_- | intronic |
| ADediting_1180517 | chr5_150225923_- | intronic |
| ADediting_1180518 | chr5_150225924_- | intronic |
| ADediting_1180519 | chr5_150225933_- | intronic |
| ADediting_1180520 | chr5_150225938_- | intronic |
| ADediting_1180521 | chr5_150225939_- | intronic |
| ADediting_1180522 | chr5_150225958_- | intronic |
| ADediting_1180523 | chr5_150225963_- | intronic |
| ADediting_1180524 | chr5_150225964_- | intronic |
| ADediting_1180525 | chr5_150225972_- | intronic |
| ADediting_1180526 | chr5_150225982_- | intronic |
| ADediting_1180527 | chr5_150226002_- | intronic |
| ADediting_1180528 | chr5_150226013_- | intronic |
| ADediting_1180529 | chr5_150226018_- | intronic |
| ADediting_1180530 | chr5_150226019_- | intronic |
| ADediting_1180531 | chr5_150226027_- | intronic |
| ADediting_1180532 | chr5_150226480_- | intronic |
| ADediting_1180533 | chr5_150226492_- | intronic |
| ADediting_1180534 | chr5_150226493_- | intronic |
| ADediting_1180535 | chr5_150226520_- | intronic |
| ADediting_1180536 | chr5_150226533_- | intronic |
| ADediting_1180537 | chr5_150226574_- | intronic |
| ADediting_1180538 | chr5_150226580_- | intronic |
| ADediting_1180539 | chr5_150226582_- | intronic |
| ADediting_1180540 | chr5_150226615_- | intronic |
| ADediting_1180541 | chr5_150226637_- | intronic |
| ADediting_1180542 | chr5_150226693_- | intronic |
| ADediting_1180543 | chr5_150226864_- | intronic |
| ADediting_1180544 | chr5_150226871_- | intronic |
| ADediting_1180545 | chr5_150226909_- | intronic |
| ADediting_1180546 | chr5_150226910_- | intronic |
| ADediting_1180547 | chr5_150226936_- | intronic |
| ADediting_1180548 | chr5_150226960_- | intronic |
| ADediting_1180549 | chr5_150226965_- | intronic |
| ADediting_1180550 | chr5_150226966_- | intronic |
| ADediting_1180551 | chr5_150226967_- | intronic |
| ADediting_1180552 | chr5_150227044_- | intronic |
| ADediting_1180553 | chr5_150227045_- | intronic |
| ADediting_1180554 | chr5_150227403_- | intronic |
| ADediting_1180555 | chr5_150227947_- | intronic |
| ADediting_1180556 | chr5_150228091_- | intronic |
| ADediting_1180557 | chr5_150231843_- | intronic |
| ADediting_1180558 | chr5_150233875_- | intronic |
| ADediting_1180559 | chr5_150233937_- | intronic |
| ADediting_1180560 | chr5_150234026_- | intronic |
| ADediting_1180561 | chr5_150234063_- | intronic |
| ADediting_1180562 | chr5_150234064_- | intronic |
| ADediting_1180563 | chr5_150234069_- | intronic |
| ADediting_1180564 | chr5_150234084_- | intronic |
| ADediting_1180565 | chr5_150234090_- | intronic |
| ADediting_1180566 | chr5_150236909_- | intronic |
| ADediting_1180567 | chr5_150238176_- | intronic |
| ADediting_1180568 | chr5_150238188_- | intronic |
| ADediting_1180569 | chr5_150238194_- | intronic |
| ADediting_1180570 | chr5_150238206_- | intronic |
| ADediting_1180571 | chr5_150238207_- | intronic |
| ADediting_1180572 | chr5_150238283_- | intronic |
| ADediting_1180573 | chr5_150238285_- | intronic |
| ADediting_1180574 | chr5_150238294_- | intronic |
| ADediting_1180575 | chr5_150238370_- | intronic |
| ADediting_1180576 | chr5_150238389_- | intronic |
| ADediting_1180577 | chr5_150238408_- | intronic |
| ADediting_1180578 | chr5_150253086_- | intronic |
| ADediting_1180579 | chr5_150253089_- | intronic |
| ADediting_1180580 | chr5_150253318_- | intronic |
| ADediting_1180581 | chr5_150254322_- | intronic |
| ADediting_1180582 | chr5_150254763_- | intronic |
| ADediting_1180583 | chr5_150255499_- | intronic |
| ADediting_1180584 | chr5_150255644_- | intronic |
| ADediting_1180585 | chr5_150257986_- | intronic |
| ADediting_1180586 | chr5_150260968_- | intronic |
| ADediting_1180587 | chr5_150262329_- | intronic |
| ADediting_1180588 | chr5_150262675_- | intronic |
| ADediting_1180589 | chr5_150265683_- | intronic |
| ADediting_1180590 | chr5_150265694_- | intronic |
| ADediting_1180591 | chr5_150265716_- | intronic |
| ADediting_1180592 | chr5_150265720_- | intronic |
| ADediting_1180593 | chr5_150265779_- | intronic |
| ADediting_1180594 | chr5_150265785_- | intronic |
| ADediting_1180595 | chr5_150265820_- | intronic |
| ADediting_1180596 | chr5_150265830_- | intronic |
| ADediting_1180597 | chr5_150265883_- | intronic |
| ADediting_1180598 | chr5_150265897_- | intronic |
| ADediting_1180599 | chr5_150267903_- | intronic |
| ADediting_1180600 | chr5_150267941_- | intronic |
| ADediting_1180601 | chr5_150267972_- | intronic |
| ADediting_1180602 | chr5_150268002_- | intronic |
| ADediting_1180603 | chr5_150268006_- | intronic |
| ADediting_1180604 | chr5_150268012_- | intronic |
| ADediting_1180605 | chr5_150268038_- | intronic |
| ADediting_1180606 | chr5_150268053_- | intronic |
| ADediting_1180607 | chr5_150268054_- | intronic |
| ADediting_1180608 | chr5_150268107_- | intronic |
| ADediting_1180609 | chr5_150268128_- | intronic |
| ADediting_1180610 | chr5_150268129_- | intronic |
| ADediting_1180611 | chr5_150268145_- | intronic |
| ADediting_1180612 | chr5_150268792_- | intronic |
| ADediting_1180613 | chr5_150268806_- | intronic |
| ADediting_1180614 | chr5_150268845_- | intronic |
| ADediting_1180615 | chr5_150268852_- | intronic |
| ADediting_1180616 | chr5_150268857_- | intronic |
| ADediting_1180617 | chr5_150268892_- | intronic |
| ADediting_1180618 | chr5_150268902_- | intronic |
| ADediting_1180619 | chr5_150268920_- | intronic |
| ADediting_1180620 | chr5_150268928_- | intronic |
| ADediting_1180621 | chr5_150268984_- | intronic |
| ADediting_1180622 | chr5_150269039_- | intronic |
| ADediting_1180623 | chr5_150269506_- | intronic |
| ADediting_1180624 | chr5_150269572_- | intronic |
| ADediting_1180625 | chr5_150269635_- | intronic |
| ADediting_1180626 | chr5_150270037_- | intronic |
| ADediting_1180627 | chr5_150272373_- | intronic |
| ADediting_1180628 | chr5_150272399_- | intronic |
| ADediting_1180629 | chr5_150272402_- | intronic |
| ADediting_1180630 | chr5_150272408_- | intronic |
| ADediting_1180631 | chr5_150272423_- | intronic |
| ADediting_1180632 | chr5_150272447_- | intronic |
| ADediting_1180633 | chr5_150286637_- | intronic |
| ADediting_1655514 | chr5_150234045_- | intronic |
| ADediting_1655515 | chr5_150238208_- | intronic |
| ADediting_1655516 | chr5_150271479_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1180495 | chr5_150224904_- | SINE | Alu | Name=AluJb |
| ADediting_1180496 | chr5_150224926_- | SINE | Alu | Name=AluJb |
| ADediting_1180497 | chr5_150224935_- | SINE | Alu | Name=AluJb |
| ADediting_1180498 | chr5_150224940_- | SINE | Alu | Name=AluJb |
| ADediting_1180499 | chr5_150224957_- | SINE | Alu | Name=AluJb |
| ADediting_1180500 | chr5_150224958_- | SINE | Alu | Name=AluJb |
| ADediting_1180501 | chr5_150224969_- | SINE | Alu | Name=AluJb |
| ADediting_1180502 | chr5_150224981_- | SINE | Alu | Name=AluJb |
| ADediting_1180503 | chr5_150224995_- | SINE | Alu | Name=AluJb |
| ADediting_1180504 | chr5_150225817_- | SINE | Alu | Name=AluSx |
| ADediting_1180505 | chr5_150225818_- | SINE | Alu | Name=AluSx |
| ADediting_1180506 | chr5_150225847_- | SINE | Alu | Name=AluSx |
| ADediting_1180507 | chr5_150225866_- | SINE | Alu | Name=AluSx |
| ADediting_1180508 | chr5_150225873_- | SINE | Alu | Name=AluSx |
| ADediting_1180509 | chr5_150225883_- | SINE | Alu | Name=AluSx |
| ADediting_1180510 | chr5_150225901_- | SINE | Alu | Name=AluSx |
| ADediting_1180511 | chr5_150225905_- | SINE | Alu | Name=AluSx |
| ADediting_1180512 | chr5_150225909_- | SINE | Alu | Name=AluSx |
| ADediting_1180513 | chr5_150225912_- | SINE | Alu | Name=AluSx |
| ADediting_1180514 | chr5_150225916_- | SINE | Alu | Name=AluSx |
| ADediting_1180515 | chr5_150225918_- | SINE | Alu | Name=AluSx |
| ADediting_1180516 | chr5_150225920_- | SINE | Alu | Name=AluSx |
| ADediting_1180517 | chr5_150225923_- | SINE | Alu | Name=AluSx |
| ADediting_1180518 | chr5_150225924_- | SINE | Alu | Name=AluSx |
| ADediting_1180519 | chr5_150225933_- | SINE | Alu | Name=AluSx |
| ADediting_1180520 | chr5_150225938_- | SINE | Alu | Name=AluSx |
| ADediting_1180521 | chr5_150225939_- | SINE | Alu | Name=AluSx |
| ADediting_1180522 | chr5_150225958_- | SINE | Alu | Name=AluSx |
| ADediting_1180523 | chr5_150225963_- | SINE | Alu | Name=AluSx |
| ADediting_1180524 | chr5_150225964_- | SINE | Alu | Name=AluSx |
| ADediting_1180525 | chr5_150225972_- | SINE | Alu | Name=AluSx |
| ADediting_1180526 | chr5_150225982_- | SINE | Alu | Name=AluSx |
| ADediting_1180527 | chr5_150226002_- | SINE | Alu | Name=AluSx |
| ADediting_1180528 | chr5_150226013_- | SINE | Alu | Name=AluSx |
| ADediting_1180529 | chr5_150226018_- | SINE | Alu | Name=AluSx |
| ADediting_1180530 | chr5_150226019_- | SINE | Alu | Name=AluSx |
| ADediting_1180531 | chr5_150226027_- | SINE | Alu | Name=AluSx |
| ADediting_1180532 | chr5_150226480_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180533 | chr5_150226492_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180534 | chr5_150226493_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180535 | chr5_150226520_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180536 | chr5_150226533_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180537 | chr5_150226574_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180538 | chr5_150226580_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180539 | chr5_150226582_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180540 | chr5_150226615_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180541 | chr5_150226637_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180542 | chr5_150226693_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180543 | chr5_150226864_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180544 | chr5_150226871_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180545 | chr5_150226909_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180546 | chr5_150226910_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180547 | chr5_150226936_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180548 | chr5_150226960_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180549 | chr5_150226965_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180550 | chr5_150226966_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180551 | chr5_150226967_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180552 | chr5_150227044_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180553 | chr5_150227045_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180554 | chr5_150227403_- | DNA | hAT-Charlie | Name=MER113 |
| ADediting_1180558 | chr5_150233875_- | SINE | Alu | Name=AluSx |
| ADediting_1180559 | chr5_150233937_- | SINE | Alu | Name=AluSx |
| ADediting_1180560 | chr5_150234026_- | SINE | Alu | Name=AluSx |
| ADediting_1180561 | chr5_150234063_- | SINE | Alu | Name=AluSx |
| ADediting_1180562 | chr5_150234064_- | SINE | Alu | Name=AluSx |
| ADediting_1180563 | chr5_150234069_- | SINE | Alu | Name=AluSx |
| ADediting_1180564 | chr5_150234084_- | SINE | Alu | Name=AluSx |
| ADediting_1180565 | chr5_150234090_- | SINE | Alu | Name=AluSx |
| ADediting_1180566 | chr5_150236909_- | SINE | Alu | Name=FAM |
| ADediting_1180567 | chr5_150238176_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180568 | chr5_150238188_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180569 | chr5_150238194_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180570 | chr5_150238206_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180571 | chr5_150238207_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180572 | chr5_150238283_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180573 | chr5_150238285_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180574 | chr5_150238294_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180575 | chr5_150238370_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180576 | chr5_150238389_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180577 | chr5_150238408_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180578 | chr5_150253086_- | SINE | MIR | Name=MIR |
| ADediting_1180579 | chr5_150253089_- | SINE | MIR | Name=MIR |
| ADediting_1180581 | chr5_150254322_- | LINE | L2 | Name=L2a |
| ADediting_1180582 | chr5_150254763_- | SINE | MIR | Name=MIRb |
| ADediting_1180583 | chr5_150255499_- | LINE | CR1 | Name=L3 |
| ADediting_1180584 | chr5_150255644_- | LINE | CR1 | Name=L3 |
| ADediting_1180585 | chr5_150257986_- | SINE | MIR | Name=MIRb |
| ADediting_1180588 | chr5_150262675_- | SINE | MIR | Name=MIR |
| ADediting_1180589 | chr5_150265683_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180590 | chr5_150265694_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180591 | chr5_150265716_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180592 | chr5_150265720_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180593 | chr5_150265779_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180594 | chr5_150265785_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180595 | chr5_150265820_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180596 | chr5_150265830_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180597 | chr5_150265883_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180598 | chr5_150265897_- | SINE | Alu | Name=AluSx1 |
| ADediting_1180599 | chr5_150267903_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180600 | chr5_150267941_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180601 | chr5_150267972_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180602 | chr5_150268002_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180603 | chr5_150268006_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180604 | chr5_150268012_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180605 | chr5_150268038_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180606 | chr5_150268053_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180607 | chr5_150268054_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180608 | chr5_150268107_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180609 | chr5_150268128_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180610 | chr5_150268129_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180611 | chr5_150268145_- | SINE | Alu | Name=AluSx3 |
| ADediting_1180612 | chr5_150268792_- | SINE | Alu | Name=AluJb |
| ADediting_1180613 | chr5_150268806_- | SINE | Alu | Name=AluJb |
| ADediting_1180614 | chr5_150268845_- | SINE | Alu | Name=AluJb |
| ADediting_1180615 | chr5_150268852_- | SINE | Alu | Name=AluJb |
| ADediting_1180616 | chr5_150268857_- | SINE | Alu | Name=AluJb |
| ADediting_1180617 | chr5_150268892_- | SINE | Alu | Name=AluJb |
| ADediting_1180618 | chr5_150268902_- | SINE | Alu | Name=AluJb |
| ADediting_1180619 | chr5_150268920_- | SINE | Alu | Name=AluJb |
| ADediting_1180620 | chr5_150268928_- | SINE | Alu | Name=AluJb |
| ADediting_1180621 | chr5_150268984_- | SINE | Alu | Name=AluJb |
| ADediting_1180622 | chr5_150269039_- | SINE | Alu | Name=AluJb |
| ADediting_1180623 | chr5_150269506_- | SINE | Alu | Name=AluJr |
| ADediting_1180624 | chr5_150269572_- | SINE | Alu | Name=AluJr |
| ADediting_1180625 | chr5_150269635_- | SINE | Alu | Name=AluJr |
| ADediting_1180626 | chr5_150270037_- | DNA | hAT-Charlie | Name=Charlie17b |
| ADediting_1180627 | chr5_150272373_- | SINE | Alu | Name=AluSq2 |
| ADediting_1180628 | chr5_150272399_- | SINE | Alu | Name=AluSq2 |
| ADediting_1180629 | chr5_150272402_- | SINE | Alu | Name=AluSq2 |
| ADediting_1180630 | chr5_150272408_- | SINE | Alu | Name=AluSq2 |
| ADediting_1180631 | chr5_150272423_- | SINE | Alu | Name=AluSq2 |
| ADediting_1180632 | chr5_150272447_- | SINE | Alu | Name=AluSq2 |
| ADediting_1655514 | chr5_150234045_- | SINE | Alu | Name=AluSx |
| ADediting_1655515 | chr5_150238208_- | SINE | Alu | Name=AluSx1 |
Top |
RNA A-to-I editing events in the alternative splicing sites for CAMK2A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for CAMK2A |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for CAMK2A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for CAMK2A |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000070808.16 | ENST00000348628.10 | CAMK2A-201 | hsa-miR-337-3p | chr5 | 150219804 | 150219811 | 8mer-1a | 150219804 | 150219824 | 152 | -13.28 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000070808.16 | ENST00000671881.1 | CAMK2A-208 | hsa-miR-337-3p | chr5 | 150219804 | 150219811 | 8mer-1a | 150219804 | 150219824 | 152 | -13.28 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000070808.16 | ENST00000672479.1 | CAMK2A-212 | hsa-miR-337-3p | chr5 | 150219804 | 150219811 | 8mer-1a | 150219804 | 150219824 | 152 | -13.28 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000348628.10 | CAMK2A-201 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000510347.2 | CAMK2A-206 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000671881.1 | CAMK2A-208 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000672396.1 | CAMK2A-210 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000672479.1 | CAMK2A-212 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000672752.1 | CAMK2A-213 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000672785.1 | CAMK2A-214 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| ADediting_286380 | chr11_79422188_- | ENSG00000070808.16 | ENST00000672829.1 | CAMK2A-215 | hsa-miR-5579-3p | chr5 | 150222236 | 150222243 | 8mer-1a | 150222236 | 150222257 | 151 | -14.85 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000070808.16 | ENST00000348628.10 | CAMK2A-201 | hsa-miR-5688 | chr5 | 150219539 | 150219545 | 7mer-m8 | 150219538 | 150219559 | 150 | -11.58 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000070808.16 | ENST00000671881.1 | CAMK2A-208 | hsa-miR-5688 | chr5 | 150219539 | 150219545 | 7mer-m8 | 150219538 | 150219559 | 150 | -11.58 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000070808.16 | ENST00000348628.10 | CAMK2A-201 | hsa-miR-1273h-3p | chr5 | 150220807 | 150220813 | 7mer-m8 | 150220806 | 150220827 | 147 | -19.46 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000070808.16 | ENST00000348628.10 | CAMK2A-201 | hsa-miR-1273h-3p | chr5 | 150221228 | 150221234 | 7mer-m8 | 150221227 | 150221248 | 152 | -15.37 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000070808.16 | ENST00000671881.1 | CAMK2A-208 | hsa-miR-1273h-3p | chr5 | 150220807 | 150220813 | 7mer-m8 | 150220806 | 150220827 | 147 | -19.46 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000070808.16 | ENST00000671881.1 | CAMK2A-208 | hsa-miR-1273h-3p | chr5 | 150221228 | 150221234 | 7mer-m8 | 150221227 | 150221248 | 152 | -15.37 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000070808.16 | ENST00000672479.1 | CAMK2A-212 | hsa-miR-1273h-3p | chr5 | 150220807 | 150220813 | 7mer-m8 | 150220806 | 150220827 | 147 | -19.46 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000070808.16 | ENST00000672479.1 | CAMK2A-212 | hsa-miR-1273h-3p | chr5 | 150221228 | 150221234 | 7mer-m8 | 150221227 | 150221248 | 152 | -15.37 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000070808.16 | ENST00000672752.1 | CAMK2A-213 | hsa-miR-1273h-3p | chr5 | 150221228 | 150221234 | 7mer-m8 | 150221227 | 150221248 | 152 | -15.37 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for CAMK2A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for CAMK2A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1180498 | chr5_150224940_- | 9.92776846948711e-08 | 0.296958567777718 | 1.33501711130232e-09 | 0.335675589180711 | 0.407634252772887 | -0.0471953197609058 |
| TCX | ADediting_1180498 | chr5_150224940_- | 8.09068080758086e-06 | 0.355389261148522 | 2.36726387883942e-05 | 0.337767593905023 | 0.712500633873958 | -0.0303347159341723 |
| TCX | ADediting_1180500 | chr5_150224958_- | 9.16975995923683e-08 | 0.419432447999123 | 2.11451985875726e-07 | 0.408466275783809 | 0.289213342478403 | -0.0871003550851492 |
| DLPFC | ADediting_1180523 | chr5_150225963_- | 2.75366422939441e-09 | 0.329542081341701 | 5.1448397397305e-07 | 0.280550103698114 | 0.0672112999150051 | 0.104089650902055 |
| TCX | ADediting_1180523 | chr5_150225963_- | 0.00232850634068735 | 0.246812194514247 | 5.3429669315477e-05 | 0.323656202052943 | 0.0542244438786728 | -0.157513851179351 |
| TCX | ADediting_1180524 | chr5_150225964_- | 0.000121734782551157 | 0.308634613415725 | 2.77400572898647e-05 | 0.335072579287005 | 0.519586501390821 | -0.0529872930183154 |
| DLPFC | ADediting_1180533 | chr5_150226492_- | 1.12702583497378e-05 | 0.246541613719919 | 1.43641630768759e-09 | 0.335061498972222 | 0.183338169733355 | 0.0757673959996853 |
| TCX | ADediting_1180533 | chr5_150226492_- | 0.00127062593466787 | 0.26073342324959 | 3.95176702769502e-07 | 0.39999435135655 | 0.0729800096453429 | -0.146828032391998 |
| TCX | ADediting_1180554 | chr5_150227403_- | 2.25677027059488e-05 | 0.338575171306672 | 4.05498133069304e-05 | 0.328515640759133 | 0.437540708781453 | -0.0638584107553202 |
| TCX | ADediting_1180562 | chr5_150234064_- | 2.69260284668824e-06 | 0.372419633021424 | 1.11095644769564e-06 | 0.385453556232531 | 0.775618662796346 | 0.0234659663779811 |
| TCX | ADediting_1180573 | chr5_150238285_- | 9.49486658781477e-06 | 0.352828568635377 | 7.4392748796443e-09 | 0.450232821523921 | 0.349508395005208 | -0.0769169973551019 |
| STG | ADediting_1180583 | chr5_150255499_- | 0.00222052257023094 | 0.32933856912539 | 0.000444063796893721 | 0.374782207443314 | 0.126994673489909 | -0.167838207130761 |
| FP | ADediting_1180584 | chr5_150255644_- | 1.65896397213284e-05 | 0.316666781937722 | 0.0260312000958849 | 0.166831160939084 | 0.435275315181071 | 0.0588420536806153 |
| STG | ADediting_1180584 | chr5_150255644_- | 0.061666415992818 | 0.204792310370874 | 0.00459858753151293 | 0.306322056252866 | 0.697677617021093 | 0.0430089901831326 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.70281635689178e-93 | 0.861895158682199 | 1.32419745219491e-102 | 0.881907326507533 | 0.101342421229559 | 0.0932275944539479 |
| AC | 7.37455304503529e-48 | 0.757641384801517 | 8.93773378048724e-67 | 0.836636076182582 | 0.859162130780497 | 0.0112785098418585 |
| PCC | 1.10397447384076e-61 | 0.875760196606092 | 7.50363743136252e-74 | 0.909219257557187 | 0.377203924892503 | 0.0642516839008629 |
| TCX | 2.35885163136563e-14 | 0.570996774379472 | 4.8871960422423e-29 | 0.75607027387035 | 2.22444354745507e-06 | -0.375279816882679 |
| FP | 2.94456131519447e-26 | 0.687638062403292 | 1.28758022821832e-19 | 0.611248771894409 | 0.143164040187258 | 0.11018150047333 |
| IFG | 5.15229419413907e-06 | 0.776004432284032 | 5.91345720596601e-06 | 0.772986311241132 | 0.987658386372597 | 0.00326064287805523 |
| PG | 3.82431231124336e-11 | 0.460336743537441 | 9.31617025698433e-17 | 0.56017668453376 | 0.00992841551858219 | -0.188622515960798 |
| STG | 2.19090868518215e-08 | 0.564794096193982 | 2.12057475020525e-08 | 0.565262146300202 | 0.104794553970012 | -0.178229630380233 |
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Relation with AD stages for CAMK2A |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| TCX | ADediting_1180524 | chr5_150225964_- | 0.0015913232781921 | 0.303031087481736 |
| TCX | ADediting_1180562 | chr5_150234064_- | 0.00165722149458475 | 0.301947504362881 |
| IFG | ADediting_1180510 | chr5_150225901_- | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_1180511 | chr5_150225905_- | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_1180519 | chr5_150225933_- | 0.0370274609990576 | 0.419124637200465 |
| IFG | ADediting_1180536 | chr5_150226533_- | 0.0112614191895443 | 0.498187153213234 |
| IFG | ADediting_1180559 | chr5_150233937_- | 0.0289148585888673 | 0.437060634316032 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000880308457213731 | 0.315520761955365 |
| PG | 5.84816787152705e-08 | -0.384833967112331 |
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RelatedDrugs for CAMK2A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| CAMK2A | Q9UQM7 | DB12010 | Fostamatinib | Calcium/calmodulin-dependent protein kinase type II subunit alpha | small molecule | approved|investigational |
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RelatedDiseases for CAMK2A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CAMK2A | C3714756 | Intellectual Disability | 2 | GENOMICS_ENGLAND |
| CAMK2A | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| CAMK2A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| CAMK2A | C0009171 | Cocaine Abuse | 1 | CTD_human |
| CAMK2A | C0011570 | Mental Depression | 1 | PSYGENET |
| CAMK2A | C0011581 | Depressive disorder | 1 | PSYGENET |
| CAMK2A | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
| CAMK2A | C0019209 | Hepatomegaly | 1 | CTD_human |
| CAMK2A | C0020429 | Hyperalgesia | 1 | CTD_human |
| CAMK2A | C0041696 | Unipolar Depression | 1 | PSYGENET |
| CAMK2A | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| CAMK2A | C0458247 | Allodynia | 1 | CTD_human |
| CAMK2A | C0600427 | Cocaine Dependence | 1 | CTD_human |
| CAMK2A | C0751211 | Hyperalgesia, Primary | 1 | CTD_human |
| CAMK2A | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human |
| CAMK2A | C0751213 | Tactile Allodynia | 1 | CTD_human |
| CAMK2A | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human |
| CAMK2A | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| CAMK2A | C1527352 | Hepatic Form of Wilson Disease | 1 | CTD_human |
| CAMK2A | C2936719 | Mechanical Allodynia | 1 | CTD_human |
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