ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for BHLHB9

Gene summary

Gene information	Gene symbol	BHLHB9
	Gene ID	80823
	Gene name	basic helix-loop-helix family member b9
	Synonyms	GASP3\|p60TRP
	Cytomap	Xq22.1
	Type of gene	protein-coding
	Description	protein BHLHb9basic helix-loop-helix domain containing, class B, 9p60-like proteintranscription regulator of 60 kDa
	Modification date	20200313
	UniProtAcc	Q6PI77,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for BHLHB9

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_1485317(102722477, +), ADediting_1485318(102722522, +), ADediting_1485319(102722523, +), ADediting_1485320(102722529, +), ADediting_1485321(102722570, +), ADediting_1485322(102723715, +), ADediting_1485323(102723721, +), ADediting_1485324(102723743, +), ADediting_1485325(102723761, +), ADediting_1485326(102723762, +), ADediting_1485327(102723799, +), ADediting_1485328(102723812, +), ADediting_1485329(102723819, +), ADediting_1485330(102723843, +), ADediting_1485331(102723844, +), ADediting_1485332(102723864, +), ADediting_1485333(102723934, +), ADediting_1485334(102724173, +), ADediting_1485335(102728652, +), ADediting_1485336(102731523, +), ADediting_1485337(102731536, +), ADediting_1485338(102731545, +), ADediting_1485339(102731559, +), ADediting_1485340(102733356, +), ADediting_1485341(102734355, +), ADediting_1485342(102734549, +), ADediting_1485343(102735474, +), ADediting_1485344(102735682, +), ADediting_1485345(102742078, +), ADediting_1485346(102742126, +), ADediting_1485347(102742152, +), ADediting_1485348(102752823, +), ADediting_1485349(102752834, +), ADediting_1485350(102752844, +), ADediting_1485351(102752863, +), ADediting_1485352(102752869, +), ADediting_1485353(102752870, +), ADediting_1485354(102752874, +), ADediting_1485355(102752899, +), ADediting_1485356(102752909, +), ADediting_1485357(102753018, +), ADediting_1485358(102753051, +), ADediting_1485359(102753057, +), ADediting_1594636(102723862, +),

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RNA editing positional annotations for BHLHB9 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_1485317	chrX_102722477_+	intronic
ADediting_1485318	chrX_102722522_+	intronic
ADediting_1485319	chrX_102722523_+	intronic
ADediting_1485320	chrX_102722529_+	intronic
ADediting_1485321	chrX_102722570_+	intronic
ADediting_1485322	chrX_102723715_+	intronic
ADediting_1485323	chrX_102723721_+	intronic
ADediting_1485324	chrX_102723743_+	intronic
ADediting_1485325	chrX_102723761_+	intronic
ADediting_1485326	chrX_102723762_+	intronic
ADediting_1485327	chrX_102723799_+	intronic
ADediting_1485328	chrX_102723812_+	intronic
ADediting_1485329	chrX_102723819_+	intronic
ADediting_1485330	chrX_102723843_+	intronic
ADediting_1485331	chrX_102723844_+	intronic
ADediting_1485332	chrX_102723864_+	intronic
ADediting_1485333	chrX_102723934_+	intronic
ADediting_1485334	chrX_102724173_+	intronic
ADediting_1485335	chrX_102728652_+	intronic
ADediting_1485336	chrX_102731523_+	intronic
ADediting_1485337	chrX_102731536_+	intronic
ADediting_1485338	chrX_102731545_+	intronic
ADediting_1485339	chrX_102731559_+	intronic
ADediting_1485340	chrX_102733356_+	intronic
ADediting_1485341	chrX_102734355_+	intronic
ADediting_1485342	chrX_102734549_+	intronic
ADediting_1485343	chrX_102735474_+	intronic
ADediting_1485344	chrX_102735682_+	intronic
ADediting_1485345	chrX_102742078_+	intronic
ADediting_1485346	chrX_102742126_+	intronic
ADediting_1485347	chrX_102742152_+	intronic
ADediting_1485348	chrX_102752823_+	UTR3
ADediting_1485349	chrX_102752834_+	UTR3
ADediting_1485350	chrX_102752844_+	UTR3
ADediting_1485351	chrX_102752863_+	UTR3
ADediting_1485352	chrX_102752869_+	UTR3
ADediting_1485353	chrX_102752870_+	UTR3
ADediting_1485354	chrX_102752874_+	UTR3
ADediting_1485355	chrX_102752899_+	UTR3
ADediting_1485356	chrX_102752909_+	UTR3
ADediting_1485357	chrX_102753018_+	UTR3
ADediting_1485358	chrX_102753051_+	UTR3
ADediting_1485359	chrX_102753057_+	UTR3
ADediting_1594636	chrX_102723862_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_1485317	chrX_102722477_+	LTR	ERVL	Name=MER21C
ADediting_1485318	chrX_102722522_+	LTR	ERVL	Name=MER21C
ADediting_1485319	chrX_102722523_+	LTR	ERVL	Name=MER21C
ADediting_1485320	chrX_102722529_+	LTR	ERVL	Name=MER21C
ADediting_1485321	chrX_102722570_+	LTR	ERVL	Name=MER21C
ADediting_1485322	chrX_102723715_+	LTR	ERVL	Name=MER21C
ADediting_1485323	chrX_102723721_+	LTR	ERVL	Name=MER21C
ADediting_1485324	chrX_102723743_+	LTR	ERVL	Name=MER21C
ADediting_1485325	chrX_102723761_+	LTR	ERVL	Name=MER21C
ADediting_1485326	chrX_102723762_+	LTR	ERVL	Name=MER21C
ADediting_1485327	chrX_102723799_+	LTR	ERVL	Name=MER21C
ADediting_1485328	chrX_102723812_+	LTR	ERVL	Name=MER21C
ADediting_1485329	chrX_102723819_+	LTR	ERVL	Name=MER21C
ADediting_1485330	chrX_102723843_+	LTR	ERVL	Name=MER21C
ADediting_1485331	chrX_102723844_+	LTR	ERVL	Name=MER21C
ADediting_1485332	chrX_102723864_+	LTR	ERVL	Name=MER21C
ADediting_1485333	chrX_102723934_+	LTR	ERVL	Name=MER21C
ADediting_1485334	chrX_102724173_+	LTR	ERVL	Name=MER21C
ADediting_1485335	chrX_102728652_+	SINE	Alu	Name=AluJo
ADediting_1485336	chrX_102731523_+	SINE	Alu	Name=AluSg
ADediting_1485337	chrX_102731536_+	SINE	Alu	Name=AluSg
ADediting_1485338	chrX_102731545_+	SINE	Alu	Name=AluSg
ADediting_1485339	chrX_102731559_+	SINE	Alu	Name=AluSg
ADediting_1485340	chrX_102733356_+	SINE	Alu	Name=AluSq
ADediting_1485341	chrX_102734355_+	SINE	Alu	Name=AluSx4
ADediting_1485342	chrX_102734549_+	SINE	Alu	Name=AluSx4
ADediting_1485343	chrX_102735474_+	SINE	Alu	Name=AluYj4
ADediting_1485344	chrX_102735682_+	SINE	Alu	Name=AluYj4
ADediting_1485345	chrX_102742078_+	LINE	L1	Name=L1MCa
ADediting_1485347	chrX_102742152_+	LTR	ERV1	Name=LTR8
ADediting_1485348	chrX_102752823_+	SINE	Alu	Name=AluSz6
ADediting_1485349	chrX_102752834_+	SINE	Alu	Name=AluSz6
ADediting_1485350	chrX_102752844_+	SINE	Alu	Name=AluSz6
ADediting_1485351	chrX_102752863_+	SINE	Alu	Name=AluSz6
ADediting_1485352	chrX_102752869_+	SINE	Alu	Name=AluSz6
ADediting_1485353	chrX_102752870_+	SINE	Alu	Name=AluSz6
ADediting_1485354	chrX_102752874_+	SINE	Alu	Name=AluSz6
ADediting_1485355	chrX_102752899_+	SINE	Alu	Name=AluSz6
ADediting_1485356	chrX_102752909_+	SINE	Alu	Name=AluSz6
ADediting_1485357	chrX_102753018_+	SINE	Alu	Name=AluSz6
ADediting_1485358	chrX_102753051_+	SINE	Alu	Name=AluSz6
ADediting_1485359	chrX_102753057_+	SINE	Alu	Name=AluSz6
ADediting_1594636	chrX_102723862_+	LTR	ERVL	Name=MER21C

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RNA A-to-I editing events in the alternative splicing sites for BHLHB9

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for BHLHB9

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for BHLHB9

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for BHLHB9

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1485348	chrX_102752823_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-4793-3p	chrX	102752819	102752825	7mer-m8	102752804	102752826	157	-22.82
ADediting_1485348	chrX_102752823_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-7703	chrX	102752818	102752824	7mer-m8	102752803	102752825	162	-25.89
ADediting_1485348	chrX_102752823_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-4793-3p	chrX	102752819	102752825	7mer-m8	102752804	102752826	157	-22.82
ADediting_1485348	chrX_102752823_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-7703	chrX	102752818	102752824	7mer-m8	102752803	102752825	162	-25.89
ADediting_1485349	chrX_102752834_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-873-3p	chrX	102752831	102752837	7mer-m8	102752812	102752838	141	-20.49
ADediting_1485349	chrX_102752834_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-873-3p	chrX	102752831	102752837	7mer-m8	102752812	102752838	141	-20.49
ADediting_1485351	chrX_102752863_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-1247-3p	chrX	102752858	102752864	7mer-m8	102752843	102752865	160	-26.82
ADediting_1485351	chrX_102752863_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-1247-3p	chrX	102752858	102752864	7mer-m8	102752843	102752865	160	-26.82
ADediting_1485353	chrX_102752870_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-3622a-3p	chrX	102752866	102752873	8mer-1a	102752851	102752873	149	-18.8
ADediting_1485353	chrX_102752870_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-3622b-3p	chrX	102752866	102752873	8mer-1a	102752853	102752873	147	-18.77
ADediting_1485353	chrX_102752870_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-3622a-3p	chrX	102752866	102752873	8mer-1a	102752851	102752873	149	-18.8
ADediting_1485353	chrX_102752870_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-3622b-3p	chrX	102752866	102752873	8mer-1a	102752853	102752873	147	-18.77
ADediting_1485354	chrX_102752874_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-1255b-2-3p	chrX	102752868	102752874	7mer-m8	102752854	102752875	140	-12.2
ADediting_1485354	chrX_102752874_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-589-5p	chrX	102752872	102752878	7mer-m8	102752859	102752879	158	-22.6
ADediting_1485354	chrX_102752874_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-1255b-2-3p	chrX	102752868	102752874	7mer-m8	102752854	102752875	140	-12.2
ADediting_1485354	chrX_102752874_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-589-5p	chrX	102752872	102752878	7mer-m8	102752859	102752879	158	-22.6
ADediting_1485355	chrX_102752899_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-6743-3p	chrX	102752894	102752900	7mer-m8	102752879	102752901	140	-19.41
ADediting_1485355	chrX_102752899_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-6743-3p	chrX	102752894	102752900	7mer-m8	102752879	102752901	140	-19.41
ADediting_1485356	chrX_102752909_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-17-3p	chrX	102752905	102752911	7mer-m8	102752891	102752912	142	-20.77
ADediting_1485356	chrX_102752909_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-17-3p	chrX	102752905	102752911	7mer-m8	102752891	102752912	142	-20.77
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-3622a-3p	chrX	102753014	102753021	8mer-1a	102753000	102753021	140	-16.04
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-3622b-3p	chrX	102753014	102753021	8mer-1a	102753001	102753021	149	-20.42
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-4324	chrX	102753012	102753018	7mer-m8	102753000	102753019	150	-17.07
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-4329	chrX	102753011	102753017	7mer-m8	102752999	102753018	155	-23.89
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-3622a-3p	chrX	102753014	102753021	8mer-1a	102753000	102753021	140	-16.04
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-3622b-3p	chrX	102753014	102753021	8mer-1a	102753001	102753021	149	-20.42
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-4324	chrX	102753012	102753018	7mer-m8	102753000	102753019	150	-17.07
ADediting_1485357	chrX_102753018_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-4329	chrX	102753011	102753017	7mer-m8	102752999	102753018	155	-23.89

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1485349	chrX_102752834_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-5186	chrX	102752831	102752837	7mer-m8	102752818	102752838	140	-9.21
ADediting_1485349	chrX_102752834_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-5186	chrX	102752831	102752837	7mer-m8	102752818	102752838	140	-9.21
ADediting_1485350	chrX_102752844_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-194-3p	chrX	102752840	102752846	7mer-m8	102752827	102752847	147	-16.32
ADediting_1485350	chrX_102752844_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-194-3p	chrX	102752840	102752846	7mer-m8	102752827	102752847	147	-16.32
ADediting_1485351	chrX_102752863_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-490-3p	chrX	102752860	102752866	7mer-m8	102752845	102752867	142	-14.39
ADediting_1485351	chrX_102752863_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-490-3p	chrX	102752860	102752866	7mer-m8	102752845	102752867	142	-14.39
ADediting_1485352	chrX_102752869_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-3614-5p	chrX	102752867	102752873	7mer-1a	102752850	102752873	151	-22.89
ADediting_1485352	chrX_102752869_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-3614-5p	chrX	102752867	102752873	7mer-1a	102752850	102752873	151	-22.89
ADediting_1485353	chrX_102752870_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-3614-5p	chrX	102752867	102752873	7mer-1a	102752850	102752873	151	-22.89
ADediting_1485353	chrX_102752870_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-3614-5p	chrX	102752867	102752873	7mer-1a	102752850	102752873	151	-22.89
ADediting_1485354	chrX_102752874_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-34b-3p	chrX	102752869	102752875	7mer-m8	102752853	102752876	143	-9.39
ADediting_1485354	chrX_102752874_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-34b-3p	chrX	102752869	102752875	7mer-m8	102752853	102752876	143	-9.39
ADediting_1485355	chrX_102752899_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-767-3p	chrX	102752893	102752899	7mer-m8	102752877	102752900	142	-12.3
ADediting_1485355	chrX_102752899_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-767-3p	chrX	102752893	102752899	7mer-m8	102752877	102752900	142	-12.3
ADediting_1485356	chrX_102752909_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-20b-3p	chrX	102752905	102752911	7mer-m8	102752891	102752912	151	-15.85
ADediting_1485356	chrX_102752909_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-20b-3p	chrX	102752905	102752911	7mer-m8	102752891	102752912	151	-15.85
ADediting_1485358	chrX_102753051_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-221-5p	chrX	102753046	102753053	8mer-1a	102753033	102753053	154	-20.45
ADediting_1485358	chrX_102753051_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-221-5p	chrX	102753046	102753053	8mer-1a	102753033	102753053	154	-20.45

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1337757	chr7_5495852_-	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-589-3p	chrX	102752799	102752805	7mer-m8	102752782	102752806	154	-14.94
ADediting_1337757	chr7_5495852_-	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-589-3p	chrX	102752799	102752805	7mer-m8	102752782	102752806	154	-14.94
ADediting_1556067	chr19_40282625_-	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-641	chrX	102753299	102753305	7mer-1a	102753281	102753305	147	-19.64
ADediting_1556067	chr19_40282625_-	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-641	chrX	102753299	102753305	7mer-1a	102753281	102753305	147	-19.64
ADediting_1631458	chr19_40282624_-	ENSG00000198908.12	ENST00000361229.8	BHLHB9-201	hsa-miR-641	chrX	102751829	102751835	7mer-m8	102751814	102751836	156	-21.59
ADediting_1631458	chr19_40282624_-	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-641	chrX	102751829	102751835	7mer-m8	102751814	102751836	156	-21.59
ADediting_1631458	chr19_40282624_-	ENSG00000198908.12	ENST00000447531.5	BHLHB9-203	hsa-miR-641	chrX	102751829	102751835	7mer-m8	102751814	102751836	156	-21.59
ADediting_1631458	chr19_40282624_-	ENSG00000198908.12	ENST00000448867.1	BHLHB9-204	hsa-miR-641	chrX	102751829	102751835	7mer-m8	102751814	102751836	156	-21.59
ADediting_1631458	chr19_40282624_-	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-641	chrX	102751829	102751835	7mer-m8	102751814	102751836	156	-21.59
ADediting_286380	chr11_79422188_-	ENSG00000198908.12	ENST00000361229.8	BHLHB9-201	hsa-miR-5579-3p	chrX	102750662	102750668	7mer-m8	102750648	102750669	158	-14.72
ADediting_286380	chr11_79422188_-	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-5579-3p	chrX	102750662	102750668	7mer-m8	102750648	102750669	158	-14.72
ADediting_286380	chr11_79422188_-	ENSG00000198908.12	ENST00000447531.5	BHLHB9-203	hsa-miR-5579-3p	chrX	102750662	102750668	7mer-m8	102750648	102750669	158	-14.72
ADediting_286380	chr11_79422188_-	ENSG00000198908.12	ENST00000448867.1	BHLHB9-204	hsa-miR-5579-3p	chrX	102750662	102750668	7mer-m8	102750648	102750669	158	-14.72
ADediting_286380	chr11_79422188_-	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-5579-3p	chrX	102750662	102750668	7mer-m8	102750648	102750669	158	-14.72
ADediting_98289	chr1_32086992_+	ENSG00000198908.12	ENST00000372735.1	BHLHB9-202	hsa-miR-5585-3p	chrX	102753370	102753376	7mer-m8	102753356	102753377	148	-10.76
ADediting_98289	chr1_32086992_+	ENSG00000198908.12	ENST00000457056.6	BHLHB9-205	hsa-miR-5585-3p	chrX	102753370	102753376	7mer-m8	102753356	102753377	148	-10.76

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_286380

chr11_79422188_-

ENSG00000198908.12

ENST00000361229.8

BHLHB9-201

hsa-miR-5579-3p

chrX

102750885

102750892

8mer-1a

102750871

102750892

147

-9.78

ADediting_286380

chr11_79422188_-

ENSG00000198908.12

ENST00000372735.1

BHLHB9-202

hsa-miR-5579-3p

chrX

102750885

102750892

8mer-1a

102750871

102750892

147

-9.78

ADediting_286380

chr11_79422188_-

ENSG00000198908.12

ENST00000447531.5

BHLHB9-203

hsa-miR-5579-3p

chrX

102750885

102750892

8mer-1a

102750871

102750892

147

-9.78

ADediting_286380

chr11_79422188_-

ENSG00000198908.12

ENST00000448867.1

BHLHB9-204

hsa-miR-5579-3p

chrX

102750885

102750892

8mer-1a

102750871

102750892

147

-9.78

ADediting_286380

chr11_79422188_-

ENSG00000198908.12

ENST00000457056.6

BHLHB9-205

hsa-miR-5579-3p

chrX

102750885

102750892

8mer-1a

102750871

102750892

147

-9.78

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for BHLHB9

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000457056.6	protein_coding
ENST00000372735.1	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1485348	ENST00000457056.6	chrX_102752823_+	4438	-1448.70	-1443.30	-1465.80
ADediting_1485349	ENST00000457056.6	chrX_102752834_+	4449	-1443.30	-1443.30	-1465.80
ADediting_1485350	ENST00000457056.6	chrX_102752844_+	4459	-1442.90	-1443.30	-1465.80
ADediting_1485351	ENST00000457056.6	chrX_102752863_+	4478	-1447.40	-1443.30	-1465.80
ADediting_1485352	ENST00000457056.6	chrX_102752869_+	4484	-1445.90	-1443.30	-1465.80
ADediting_1485353	ENST00000457056.6	chrX_102752870_+	4485	-1446.80	-1443.30	-1465.80
ADediting_1485354	ENST00000457056.6	chrX_102752874_+	4489	-1444.40	-1443.30	-1465.80
ADediting_1485355	ENST00000457056.6	chrX_102752899_+	4514	-1445.14	-1443.30	-1465.80
ADediting_1485356	ENST00000457056.6	chrX_102752909_+	4524	-1447.50	-1443.30	-1465.80
ADediting_1485357	ENST00000457056.6	chrX_102753018_+	4633	-1447.90	-1443.30	-1465.80
ADediting_1485358	ENST00000457056.6	chrX_102753051_+	4666	-1442.50	-1443.30	-1465.80
ADediting_1485359	ENST00000457056.6	chrX_102753057_+	4672	-1443.30	-1443.30	-1465.80
ADediting_1485348	ENST00000372735.1	chrX_102752823_+	4413	-1433.94	-1430.44	-1453.10
ADediting_1485349	ENST00000372735.1	chrX_102752834_+	4424	-1431.44	-1430.44	-1453.10
ADediting_1485350	ENST00000372735.1	chrX_102752844_+	4434	-1430.24	-1430.44	-1453.10
ADediting_1485351	ENST00000372735.1	chrX_102752863_+	4453	-1432.60	-1430.44	-1453.10
ADediting_1485352	ENST00000372735.1	chrX_102752869_+	4459	-1431.90	-1430.44	-1453.10
ADediting_1485353	ENST00000372735.1	chrX_102752870_+	4460	-1432.10	-1430.44	-1453.10
ADediting_1485354	ENST00000372735.1	chrX_102752874_+	4464	-1430.90	-1430.44	-1453.10
ADediting_1485355	ENST00000372735.1	chrX_102752899_+	4489	-1431.84	-1430.44	-1453.10
ADediting_1485356	ENST00000372735.1	chrX_102752909_+	4499	-1433.74	-1430.44	-1453.10
ADediting_1485357	ENST00000372735.1	chrX_102753018_+	4608	-1436.64	-1430.44	-1453.10
ADediting_1485358	ENST00000372735.1	chrX_102753051_+	4641	-1429.64	-1430.44	-1453.10
ADediting_1485359	ENST00000372735.1	chrX_102753057_+	4647	-1430.44	-1430.44	-1453.10

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for BHLHB9

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_1485317	chrX_102722477_+	2.54520904960183e-08	0.435531833569521	3.73250330093951e-12	0.528231543560555	0.0025850873137986	0.244330713067666
CER	ADediting_1485318	chrX_102722522_+	9.8389398265674e-09	0.446952048690804	7.25513229323846e-12	0.52214259029165	0.00234277206237796	0.246667870656939
CER	ADediting_1485319	chrX_102722523_+	4.97718131328916e-13	0.545979580757115	1.1204716923956e-13	0.558474621465228	0.00115498659310693	0.262859449434737
CER	ADediting_1485320	chrX_102722529_+	4.46338034064157e-13	0.546910379732041	3.91115103488659e-17	0.617465434103557	0.00473492140779417	0.229456569741328
CER	ADediting_1485321	chrX_102722570_+	1.45006016490591e-06	0.381590520321601	1.91757005327376e-10	0.490245252367524	0.00727273058096929	0.218331102637693
CER	ADediting_1485322	chrX_102723715_+	8.08224822158647e-05	0.316205834363108	1.67525804061068e-06	0.37947619629756	0.0757972524798235	0.145422759858738
CER	ADediting_1485323	chrX_102723721_+	6.62619924786453e-05	0.319805870304382	2.35229544880775e-10	0.488141296077264	0.00750742883997472	0.217486807409104
CER	ADediting_1485324	chrX_102723743_+	6.47341180158648e-06	0.358920954432649	1.56681795496943e-10	0.492311360773501	0.0334888673689202	0.17373223061636
CER	ADediting_1485325	chrX_102723761_+	0.000362949279206368	0.287372768203944	3.17516289585655e-11	0.508169492282434	0.0044253053083932	0.231163882878883
CER	ADediting_1485326	chrX_102723762_+	7.57586554291504e-06	0.3564348222508	2.4675980185763e-11	0.510601249095197	0.0484774401202289	0.161400061737881
CER	ADediting_1485328	chrX_102723812_+	1.07253132246718e-09	0.472055961668205	3.66553599355644e-14	0.567507443344622	0.0187045428202091	0.191806780799247
CER	ADediting_1485329	chrX_102723819_+	1.06969530180672e-08	0.445964110940324	3.98785521400079e-12	0.527630699448631	0.0231515126384798	0.185361025973451
CER	ADediting_1485330	chrX_102723843_+	0.000140348342248036	0.305956028886836	3.70872793657054e-06	0.367562982579529	0.0320909742958004	0.175108142648973
CER	ADediting_1485331	chrX_102723844_+	0.000687057960064493	0.274139193486003	2.83591748446304e-10	0.486203486762233	0.281098796029937	0.0885742949258424
CER	ADediting_1485332	chrX_102723864_+	9.44251528362478e-06	0.352917405099224	2.38244708026775e-09	0.46324783715712	0.0495904450992951	0.160618653494731
CER	ADediting_1485333	chrX_102723934_+	1.64735530566461e-08	0.440811363350694	4.69651572417907e-13	0.546475785302643	0.00944229686184709	0.211299891506181
CER	ADediting_1485334	chrX_102724173_+	1.10633370565419e-06	0.385513634394755	2.50169389283781e-10	0.487504450751029	0.0267968282250414	0.180829728830356

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	9.49442636878073e-117	0.905589872822308	4.82376119107464e-84	0.840693019547921	0.152438731062588	0.0814676093543946
AC	4.05281330007212e-103	0.920378456740041	1.0499835866768e-82	0.881305075981785	0.000730257908539636	0.212264998772136
PCC	7.11171653286853e-68	0.894172166571804	1.99867389934242e-75	0.912795873843231	0.871005487490056	0.0118267317625595
CER	3.33013942199346e-39	0.829112767542668	3.117516267032e-19	0.648079621045828	0.884491575763718	0.0119615187115997
TCX	1.01174765274744e-36	0.813884487122655	4.75038666946638e-32	0.780898290096957	0.0497933416316514	-0.160477778410384
FP	1.04979778292699e-15	0.553963803659865	7.62202247980805e-26	0.683486414162744	0.202248296419588	-0.0960337156245355
IFG	0.00027180454930316	0.666898544670749	0.00213937017553466	0.584781781239975	0.377838868149632	-0.184294538327949
PG	6.11999308449154e-42	0.795782208794095	2.92560554294998e-36	0.759908667553075	0.0230183658397656	-0.166630270705662
STG	8.07210066214453e-14	0.703945283772499	6.39841545627495e-19	0.787527942650642	0.114861366979433	-0.173325831398349

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Relation with AD stages for BHLHB9

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_1485317	chrX_102722477_+	0.000108607078927685	0.363825945057989
CER	ADediting_1485320	chrX_102722529_+	5.84059167863926e-05	0.376775372953699
CER	ADediting_1485321	chrX_102722570_+	6.68107064037658e-06	0.418193950501587
CER	ADediting_1485322	chrX_102723715_+	7.87539564865817e-07	0.454284149733833
CER	ADediting_1485323	chrX_102723721_+	5.88051686612327e-05	0.376636090514213
CER	ADediting_1485324	chrX_102723743_+	2.66249926660967e-05	0.392428258359259
CER	ADediting_1485325	chrX_102723761_+	0.000355480731686089	0.337420919899902
CER	ADediting_1485326	chrX_102723762_+	0.000137104556433033	0.358816192188421
CER	ADediting_1485328	chrX_102723812_+	8.51990965204629e-06	0.413814440849001

Correlation between AD stages and this gene's expression

Tissue

P-val

Coeff.

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RelatedDrugs for BHLHB9

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for BHLHB9

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

Home

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Statistics

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Gene summary for BHLHB9

RNA A-to-I events for BHLHB9

RNA editing positional annotations for BHLHB9 using Annovar

RNA A-to-I editing events in the alternative splicing sites for BHLHB9

Differntial gene expression between RNA A-to-I edited versus non-edited samples for BHLHB9

Protein coding region RNA A-to-I editings for BHLHB9

The effects of the RNA editing to the miRNA binding sites for BHLHB9

The effects of the RNA editing to the stability of the RNA structures for BHLHB9

Relation with ADAR for BHLHB9

Relation with AD stages for BHLHB9

RelatedDrugs for BHLHB9

RelatedDiseases for BHLHB9

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene