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Differntial gene expression between RNA A-to-I edited versus non-edited samples | |
The effects of the RNA editing to the stability of the RNA structures | |
Gene summary for INTS5 |
Gene summary |
Gene information | Gene symbol | INTS5 | Gene ID | 80789 |
Gene name | integrator complex subunit 5 | |
Synonyms | INT5|KIAA1698 | |
Cytomap | 11q12.3 | |
Type of gene | protein-coding | |
Description | integrator complex subunit 5 | |
Modification date | 20200313 | |
UniProtAcc | Q6P9B9, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
INTS5 | GO:0016180 | snRNA processing | 16239144 |
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RNA A-to-I events for INTS5 |
RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
RNA editing frequencies across three data sets. |
The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
RNA A-to-I editing events in AD. |
ADediting_262135(62649211, -), |
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RNA editing positional annotations for INTS5 using Annovar |
Protein coding RNA editing(s). |
ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
ADediting_262135 | chr11_62649211_- | nonsynonymous SNV | ENST00000330574.2 | c.A869G | p.K290R | 0.0 | 0.959 | -1.85 |
Gene structure information of RNA editing(s). |
ADeditome ID | Position | Variant type |
ADediting_262135 | chr11_62649211_- | exonic |
Repat-regional RNA editing(s). |
ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for INTS5 |
RNA A-to-I editing(s) in the alternative splicing sites. |
AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for INTS5 |
Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for INTS5 |
- Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for INTS5 |
RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in lncRNA gained miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in lncRNA lost miRNA binding sites. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs gained binding to lncRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs lost binding to lncRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
ADediting_291761 | chr11_93733708_- | ENSG00000185085.2 | ENST00000330574.2 | INTS5-201 | hsa-miR-1304-3p | chr11 | 62646978 | 62646985 | 8mer-1a | 62646978 | 62647001 | 154 | -23.99 |
Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for INTS5 |
- RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000330574.2 | protein_coding |
RNA A-to-I editing in miRNA. |
ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
RNA A-to-I editing in mRNA. |
ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
ADediting_262135 | ENST00000330574.2 | chr11_62649211_- | 922 | -1409.10 | -1405.60 | -1409.10 |
RNA A-to-I editing in lncRNA. |
ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for INTS5 |
Correlation between ADAR gene expression and RNA editing frequency |
Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
Correlation between ADAR gene expression and this gene's expression |
Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
DLPFC | 7.4400499185938e-92 | 0.859681828998895 | 4.06864936524523e-94 | 0.864709079547187 | 6.44078747475689e-07 | 0.278226032430487 |
AC | 2.52495447041775e-107 | 0.926593357484587 | 1.81238676494625e-59 | 0.810213169871754 | 1.17447595829285e-13 | 0.446564978349483 |
PCC | 2.05544546326199e-77 | 0.917101512407204 | 3.30516363248604e-73 | 0.907712459011858 | 0.0131699676232807 | 0.179107005115509 |
CER | 6.17724065284628e-24 | 0.705975402769385 | 6.17226065266929e-12 | 0.523634668976248 | 0.0588974289780946 | 0.154597489763884 |
TCX | 2.26679213838104e-55 | 0.900436820031347 | 1.09786485052584e-23 | 0.703216913117758 | 0.101616779627304 | 0.134183149977237 |
FP | 4.703005027306e-26 | 0.685602741364494 | 5.21044258950344e-24 | 0.664173126246347 | 4.19504474691222e-05 | 0.301971786750432 |
IFG | 3.31628041939493e-09 | 0.887592833004201 | 3.82729181764569e-07 | 0.825328692934928 | 0.309146556494277 | 0.211930528630958 |
STG | 8.70443931525529e-23 | 0.833021630689304 | 2.2532935660568e-11 | 0.649872324055401 | 0.52980579289099 | 0.0695119838242102 |
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Relation with AD stages for INTS5 |
Correlation between AD stages and RNA editing frequency |
Tissue | ADeditomID | position | P-val | Coeff. |
Correlation between AD stages and this gene's expression |
Tissue | P-val | Coeff. |
TCX | 3.58521805346814e-05 | 0.390012284921932 |
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RelatedDrugs for INTS5 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INTS5 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |