ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for CALM2

Gene summary

Gene information	Gene symbol	CALM2
	Gene ID	805
	Gene name	calmodulin 2
	Synonyms	CALM\|CALML2\|CAM1\|CAM3\|CAMC\|CAMII\|CAMIII\|LQT15\|PHKD\|PHKD2\|caM
	Cytomap	2p21
	Type of gene	protein-coding
	Description	calmodulin-2Calmodulin-1Calmodulin-3LP7057 proteincalmodulin 2 (phosphorylase kinase, delta)phosphorylase kinase deltaphosphorylase kinase subunit deltaprepro-calmodulin 2
	Modification date	20200320
	UniProtAcc	P0DP24,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CALM2	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	20226167
CALM2	GO:0032516	positive regulation of phosphoprotein phosphatase activity	8631777
CALM2	GO:0035307	positive regulation of protein dephosphorylation	8631777
CALM2	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	8631777
CALM2	GO:0051592	response to calcium ion	7607248
CALM2	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	26164367
CALM2	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	20226167

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RNA A-to-I events for CALM2

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_878944(47163460, -), ADediting_878945(47163485, -), ADediting_878946(47163493, -), ADediting_878947(47163498, -), ADediting_878948(47163500, -), ADediting_878949(47163541, -), ADediting_878950(47163544, -), ADediting_878951(47163565, -), ADediting_878952(47163570, -), ADediting_878953(47163571, -), ADediting_878954(47163597, -), ADediting_878955(47163605, -), ADediting_878956(47163607, -), ADediting_878957(47163609, -), ADediting_878958(47163610, -), ADediting_878959(47163614, -), ADediting_878960(47163625, -), ADediting_878961(47163635, -), ADediting_878962(47163636, -), ADediting_878963(47163639, -), ADediting_878964(47163650, -), ADediting_878965(47163664, -), ADediting_878966(47163669, -), ADediting_878967(47163678, -), ADediting_878968(47163699, -), ADediting_878969(47163704, -), ADediting_878970(47163705, -), ADediting_878971(47163722, -), ADediting_878972(47163724, -), ADediting_878973(47163861, -), ADediting_878974(47163867, -), ADediting_878975(47163873, -), ADediting_878976(47163888, -), ADediting_878977(47163897, -), ADediting_878978(47163901, -), ADediting_878979(47163981, -), ADediting_878980(47164003, -), ADediting_878981(47164048, -), ADediting_878982(47164175, -), ADediting_878983(47164191, -), ADediting_878984(47164457, -), ADediting_878985(47164475, -), ADediting_878986(47164485, -), ADediting_878987(47164511, -), ADediting_878988(47164514, -), ADediting_878989(47164534, -), ADediting_878990(47164570, -), ADediting_878991(47167464, -), ADediting_878992(47167502, -), ADediting_878993(47167511, -), ADediting_878994(47167570, -), ADediting_878995(47167900, -), ADediting_878996(47167907, -), ADediting_878997(47168495, -), ADediting_878998(47168504, -), ADediting_878999(47168522, -), ADediting_879000(47168528, -), ADediting_879001(47168536, -), ADediting_879002(47168547, -), ADediting_879003(47168569, -), ADediting_879004(47168573, -), ADediting_879005(47168576, -), ADediting_879006(47168582, -), ADediting_879007(47168611, -), ADediting_879008(47168621, -), ADediting_879009(47168633, -), ADediting_879010(47168647, -), ADediting_879011(47168701, -), ADediting_879012(47168707, -), ADediting_879013(47168874, -), ADediting_879014(47168886, -), ADediting_879015(47168889, -), ADediting_879016(47168902, -), ADediting_879017(47168906, -), ADediting_879018(47168915, -), ADediting_879019(47168948, -), ADediting_879020(47168951, -), ADediting_879021(47168956, -), ADediting_879022(47168971, -), ADediting_879023(47168981, -), ADediting_879024(47168997, -), ADediting_879025(47169005, -), ADediting_879026(47169038, -), ADediting_879027(47169046, -), ADediting_879028(47169047, -), ADediting_879029(47169055, -), ADediting_879030(47169359, -), ADediting_879031(47169384, -), ADediting_879032(47169406, -), ADediting_879033(47169410, -), ADediting_879034(47169736, -), ADediting_1563583(47163459, -), ADediting_1563584(47163941, -), ADediting_1563585(47164535, -), ADediting_1563586(47168556, -), ADediting_1563587(47168648, -), ADediting_1563588(47168875, -), ADediting_1563589(47168942, -), ADediting_1563590(47168991, -), ADediting_1637777(47163626, -), ADediting_1637778(47167611, -), ADediting_1637779(47168916, -), ADediting_1637780(47168957, -), ADediting_1637781(47169002, -), ADediting_1637782(47169063, -),

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RNA editing positional annotations for CALM2 using Annovar

Protein coding RNA editing(s).

ADeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
ADediting_1637778	chr2_47167611_-	nonsynonymous SNV	ENST00000409563.5	c.A40G	p.S14G	0.0	.	-0.24
ADediting_878992	chr2_47167502_-	nonsynonymous SNV	ENST00000409563.5	c.A149G	p.Q50R	0.006	.	-0.36
ADediting_878993	chr2_47167511_-	nonsynonymous SNV	ENST00000409563.5	c.A140G	p.H47R	0.031	.	0.35
ADediting_878994	chr2_47167570_-	synonymous SNV	ENST00000409563.5	c.A81G	p.T27T	.	.	.

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_878944	chr2_47163460_-	intronic
ADediting_878945	chr2_47163485_-	intronic
ADediting_878946	chr2_47163493_-	intronic
ADediting_878947	chr2_47163498_-	intronic
ADediting_878948	chr2_47163500_-	intronic
ADediting_878949	chr2_47163541_-	intronic
ADediting_878950	chr2_47163544_-	intronic
ADediting_878951	chr2_47163565_-	intronic
ADediting_878952	chr2_47163570_-	intronic
ADediting_878953	chr2_47163571_-	intronic
ADediting_878954	chr2_47163597_-	intronic
ADediting_878955	chr2_47163605_-	intronic
ADediting_878956	chr2_47163607_-	intronic
ADediting_878957	chr2_47163609_-	intronic
ADediting_878958	chr2_47163610_-	intronic
ADediting_878959	chr2_47163614_-	intronic
ADediting_878960	chr2_47163625_-	intronic
ADediting_878961	chr2_47163635_-	intronic
ADediting_878962	chr2_47163636_-	intronic
ADediting_878963	chr2_47163639_-	intronic
ADediting_878964	chr2_47163650_-	intronic
ADediting_878965	chr2_47163664_-	intronic
ADediting_878966	chr2_47163669_-	intronic
ADediting_878967	chr2_47163678_-	intronic
ADediting_878968	chr2_47163699_-	intronic
ADediting_878969	chr2_47163704_-	intronic
ADediting_878970	chr2_47163705_-	intronic
ADediting_878971	chr2_47163722_-	intronic
ADediting_878972	chr2_47163724_-	intronic
ADediting_878973	chr2_47163861_-	intronic
ADediting_878974	chr2_47163867_-	intronic
ADediting_878975	chr2_47163873_-	intronic
ADediting_878976	chr2_47163888_-	intronic
ADediting_878977	chr2_47163897_-	intronic
ADediting_878978	chr2_47163901_-	intronic
ADediting_878979	chr2_47163981_-	intronic
ADediting_878980	chr2_47164003_-	intronic
ADediting_878981	chr2_47164048_-	intronic
ADediting_878982	chr2_47164175_-	intronic
ADediting_878983	chr2_47164191_-	intronic
ADediting_878984	chr2_47164457_-	intronic
ADediting_878985	chr2_47164475_-	intronic
ADediting_878986	chr2_47164485_-	intronic
ADediting_878987	chr2_47164511_-	intronic
ADediting_878988	chr2_47164514_-	intronic
ADediting_878989	chr2_47164534_-	intronic
ADediting_878990	chr2_47164570_-	intronic
ADediting_878991	chr2_47167464_-	intronic
ADediting_878992	chr2_47167502_-	exonic
ADediting_878993	chr2_47167511_-	exonic
ADediting_878994	chr2_47167570_-	exonic
ADediting_878995	chr2_47167900_-	intronic
ADediting_878996	chr2_47167907_-	intronic
ADediting_878997	chr2_47168495_-	intronic
ADediting_878998	chr2_47168504_-	intronic
ADediting_878999	chr2_47168522_-	intronic
ADediting_879000	chr2_47168528_-	intronic
ADediting_879001	chr2_47168536_-	intronic
ADediting_879002	chr2_47168547_-	intronic
ADediting_879003	chr2_47168569_-	intronic
ADediting_879004	chr2_47168573_-	intronic
ADediting_879005	chr2_47168576_-	intronic
ADediting_879006	chr2_47168582_-	intronic
ADediting_879007	chr2_47168611_-	intronic
ADediting_879008	chr2_47168621_-	intronic
ADediting_879009	chr2_47168633_-	intronic
ADediting_879010	chr2_47168647_-	intronic
ADediting_879011	chr2_47168701_-	intronic
ADediting_879012	chr2_47168707_-	intronic
ADediting_879013	chr2_47168874_-	intronic
ADediting_879014	chr2_47168886_-	intronic
ADediting_879015	chr2_47168889_-	intronic
ADediting_879016	chr2_47168902_-	intronic
ADediting_879017	chr2_47168906_-	intronic
ADediting_879018	chr2_47168915_-	intronic
ADediting_879019	chr2_47168948_-	intronic
ADediting_879020	chr2_47168951_-	intronic
ADediting_879021	chr2_47168956_-	intronic
ADediting_879022	chr2_47168971_-	intronic
ADediting_879023	chr2_47168981_-	intronic
ADediting_879024	chr2_47168997_-	intronic
ADediting_879025	chr2_47169005_-	intronic
ADediting_879026	chr2_47169038_-	intronic
ADediting_879027	chr2_47169046_-	intronic
ADediting_879028	chr2_47169047_-	intronic
ADediting_879029	chr2_47169055_-	intronic
ADediting_879030	chr2_47169359_-	intronic
ADediting_879031	chr2_47169384_-	intronic
ADediting_879032	chr2_47169406_-	intronic
ADediting_879033	chr2_47169410_-	intronic
ADediting_879034	chr2_47169736_-	intronic
ADediting_1563583	chr2_47163459_-	intronic
ADediting_1563584	chr2_47163941_-	intronic
ADediting_1563585	chr2_47164535_-	intronic
ADediting_1563586	chr2_47168556_-	intronic
ADediting_1563587	chr2_47168648_-	intronic
ADediting_1563588	chr2_47168875_-	intronic
ADediting_1563589	chr2_47168942_-	intronic
ADediting_1563590	chr2_47168991_-	intronic
ADediting_1637777	chr2_47163626_-	intronic
ADediting_1637778	chr2_47167611_-	exonic
ADediting_1637779	chr2_47168916_-	intronic
ADediting_1637780	chr2_47168957_-	intronic
ADediting_1637781	chr2_47169002_-	intronic
ADediting_1637782	chr2_47169063_-	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_878944	chr2_47163460_-	SINE	Alu	Name=AluSp
ADediting_878945	chr2_47163485_-	SINE	Alu	Name=AluSp
ADediting_878946	chr2_47163493_-	SINE	Alu	Name=AluSp
ADediting_878947	chr2_47163498_-	SINE	Alu	Name=AluSp
ADediting_878948	chr2_47163500_-	SINE	Alu	Name=AluSp
ADediting_878949	chr2_47163541_-	SINE	Alu	Name=AluSp
ADediting_878950	chr2_47163544_-	SINE	Alu	Name=AluSp
ADediting_878951	chr2_47163565_-	SINE	Alu	Name=AluSp
ADediting_878952	chr2_47163570_-	SINE	Alu	Name=AluSp
ADediting_878953	chr2_47163571_-	SINE	Alu	Name=AluSp
ADediting_878954	chr2_47163597_-	SINE	Alu	Name=AluSp
ADediting_878955	chr2_47163605_-	SINE	Alu	Name=AluSp
ADediting_878956	chr2_47163607_-	SINE	Alu	Name=AluSp
ADediting_878957	chr2_47163609_-	SINE	Alu	Name=AluSp
ADediting_878958	chr2_47163610_-	SINE	Alu	Name=AluSp
ADediting_878959	chr2_47163614_-	SINE	Alu	Name=AluSp
ADediting_878960	chr2_47163625_-	SINE	Alu	Name=AluSp
ADediting_878961	chr2_47163635_-	SINE	Alu	Name=AluSp
ADediting_878962	chr2_47163636_-	SINE	Alu	Name=AluSp
ADediting_878963	chr2_47163639_-	SINE	Alu	Name=AluSp
ADediting_878964	chr2_47163650_-	SINE	Alu	Name=AluSp
ADediting_878965	chr2_47163664_-	SINE	Alu	Name=AluSp
ADediting_878966	chr2_47163669_-	SINE	Alu	Name=AluSp
ADediting_878967	chr2_47163678_-	SINE	Alu	Name=AluSp
ADediting_878968	chr2_47163699_-	SINE	Alu	Name=AluSp
ADediting_878969	chr2_47163704_-	SINE	Alu	Name=AluSp
ADediting_878970	chr2_47163705_-	SINE	Alu	Name=AluSp
ADediting_878971	chr2_47163722_-	SINE	Alu	Name=AluSp
ADediting_878972	chr2_47163724_-	SINE	Alu	Name=AluSp
ADediting_878973	chr2_47163861_-	SINE	Alu	Name=AluSx
ADediting_878974	chr2_47163867_-	SINE	Alu	Name=AluSx
ADediting_878975	chr2_47163873_-	SINE	Alu	Name=AluSx
ADediting_878976	chr2_47163888_-	SINE	Alu	Name=AluSx
ADediting_878977	chr2_47163897_-	SINE	Alu	Name=AluSx
ADediting_878978	chr2_47163901_-	SINE	Alu	Name=AluSx
ADediting_878979	chr2_47163981_-	SINE	Alu	Name=AluYm1
ADediting_878980	chr2_47164003_-	SINE	Alu	Name=AluYm1
ADediting_878981	chr2_47164048_-	SINE	Alu	Name=AluYm1
ADediting_878982	chr2_47164175_-	SINE	Alu	Name=AluYm1
ADediting_878983	chr2_47164191_-	SINE	Alu	Name=AluYm1
ADediting_878984	chr2_47164457_-	SINE	Alu	Name=AluSx
ADediting_878985	chr2_47164475_-	SINE	Alu	Name=AluSx
ADediting_878986	chr2_47164485_-	SINE	Alu	Name=AluSx
ADediting_878987	chr2_47164511_-	SINE	Alu	Name=AluSx
ADediting_878988	chr2_47164514_-	SINE	Alu	Name=AluSx
ADediting_878989	chr2_47164534_-	SINE	Alu	Name=AluSx
ADediting_878990	chr2_47164570_-	SINE	Alu	Name=AluSx
ADediting_878991	chr2_47167464_-	SINE	Alu	Name=AluSx
ADediting_878992	chr2_47167502_-	SINE	Alu	Name=AluSx
ADediting_878993	chr2_47167511_-	SINE	Alu	Name=AluSx
ADediting_878994	chr2_47167570_-	SINE	Alu	Name=AluSx
ADediting_878995	chr2_47167900_-	SINE	Alu	Name=FLAM_C
ADediting_878996	chr2_47167907_-	SINE	Alu	Name=FLAM_C
ADediting_878997	chr2_47168495_-	SINE	Alu	Name=AluSp
ADediting_878998	chr2_47168504_-	SINE	Alu	Name=AluSp
ADediting_878999	chr2_47168522_-	SINE	Alu	Name=AluSp
ADediting_879000	chr2_47168528_-	SINE	Alu	Name=AluSp
ADediting_879001	chr2_47168536_-	SINE	Alu	Name=AluSp
ADediting_879002	chr2_47168547_-	SINE	Alu	Name=AluSp
ADediting_879003	chr2_47168569_-	SINE	Alu	Name=AluSp
ADediting_879004	chr2_47168573_-	SINE	Alu	Name=AluSp
ADediting_879005	chr2_47168576_-	SINE	Alu	Name=AluSp
ADediting_879006	chr2_47168582_-	SINE	Alu	Name=AluSp
ADediting_879007	chr2_47168611_-	SINE	Alu	Name=AluSp
ADediting_879008	chr2_47168621_-	SINE	Alu	Name=AluSp
ADediting_879009	chr2_47168633_-	SINE	Alu	Name=AluSp
ADediting_879010	chr2_47168647_-	SINE	Alu	Name=AluSp
ADediting_879011	chr2_47168701_-	SINE	Alu	Name=AluSp
ADediting_879012	chr2_47168707_-	SINE	Alu	Name=AluSp
ADediting_879013	chr2_47168874_-	SINE	Alu	Name=AluSz
ADediting_879014	chr2_47168886_-	SINE	Alu	Name=AluSz
ADediting_879015	chr2_47168889_-	SINE	Alu	Name=AluSz
ADediting_879016	chr2_47168902_-	SINE	Alu	Name=AluSz
ADediting_879017	chr2_47168906_-	SINE	Alu	Name=AluSz
ADediting_879018	chr2_47168915_-	SINE	Alu	Name=AluSz
ADediting_879019	chr2_47168948_-	SINE	Alu	Name=AluSz
ADediting_879020	chr2_47168951_-	SINE	Alu	Name=AluSz
ADediting_879021	chr2_47168956_-	SINE	Alu	Name=AluSz
ADediting_879022	chr2_47168971_-	SINE	Alu	Name=AluSz
ADediting_879023	chr2_47168981_-	SINE	Alu	Name=AluSz
ADediting_879024	chr2_47168997_-	SINE	Alu	Name=AluSz
ADediting_879025	chr2_47169005_-	SINE	Alu	Name=AluSz
ADediting_879026	chr2_47169038_-	SINE	Alu	Name=AluSz
ADediting_879027	chr2_47169046_-	SINE	Alu	Name=AluSz
ADediting_879028	chr2_47169047_-	SINE	Alu	Name=AluSz
ADediting_879029	chr2_47169055_-	SINE	Alu	Name=AluSz
ADediting_879030	chr2_47169359_-	SINE	Alu	Name=AluJo
ADediting_879031	chr2_47169384_-	SINE	Alu	Name=AluJo
ADediting_879032	chr2_47169406_-	SINE	Alu	Name=AluJo
ADediting_879033	chr2_47169410_-	SINE	Alu	Name=AluJo
ADediting_1563583	chr2_47163459_-	SINE	Alu	Name=AluSp
ADediting_1563584	chr2_47163941_-	SINE	Alu	Name=AluSx
ADediting_1563585	chr2_47164535_-	SINE	Alu	Name=AluSx
ADediting_1563586	chr2_47168556_-	SINE	Alu	Name=AluSp
ADediting_1563587	chr2_47168648_-	SINE	Alu	Name=AluSp
ADediting_1563588	chr2_47168875_-	SINE	Alu	Name=AluSz
ADediting_1563589	chr2_47168942_-	SINE	Alu	Name=AluSz
ADediting_1563590	chr2_47168991_-	SINE	Alu	Name=AluSz
ADediting_1637777	chr2_47163626_-	SINE	Alu	Name=AluSp
ADediting_1637778	chr2_47167611_-	SINE	Alu	Name=AluSx
ADediting_1637779	chr2_47168916_-	SINE	Alu	Name=AluSz
ADediting_1637780	chr2_47168957_-	SINE	Alu	Name=AluSz
ADediting_1637781	chr2_47169002_-	SINE	Alu	Name=AluSz
ADediting_1637782	chr2_47169063_-	SINE	Alu	Name=AluSz

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RNA A-to-I editing events in the alternative splicing sites for CALM2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CALM2

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for CALM2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CALM2

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1563583

chr2_47163459_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-4535

chr2

47163454

47163460

7mer-m8

47163453

47163470

143

-16.95

ADediting_1563583

chr2_47163459_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-659-5p

chr2

47163454

47163461

8mer-1a

47163454

47163475

152

-15.74

ADediting_878946

chr2_47163493_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-652-3p

chr2

47163489

47163495

7mer-m8

47163488

47163509

146

-15.03

ADediting_878948

chr2_47163500_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-7977

chr2

47163498

47163504

7mer-m8

47163497

47163515

158

-26.56

ADediting_878949

chr2_47163541_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-331-3p

chr2

47163539

47164164

8mer-1a

47163539

47164177

145

-20.34

ADediting_878949

chr2_47163541_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-4292

chr2

47163541

47164165

7mer-m8

47163540

47164174

143

-23.76

ADediting_878949

chr2_47163541_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-6791-5p

chr2

47163541

47164165

7mer-m8

47163540

47164181

155

-35.51

ADediting_878982

chr2_47164175_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-17-3p

chr2

47164175

47164181

7mer-m8

47164174

47164195

150

-16.2

ADediting_878982

chr2_47164175_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-596

chr2

47164172

47164178

7mer-m8

47164171

47164191

140

-18.42

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1563583

chr2_47163459_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-5009-5p

chr2

47163454

47163460

7mer-m8

47163453

47163477

150

-15.29

ADediting_878945

chr2_47163485_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-106a-3p

chr2

47163485

47163491

7mer-m8

47163484

47163503

144

-13.12

ADediting_878945

chr2_47163485_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-122-5p

chr2

47163480

47163486

7mer-1a

47163480

47163498

143

-24.82

ADediting_878945

chr2_47163485_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-3666

chr2

47163483

47163489

7mer-m8

47163482

47163504

149

-13.95

ADediting_878945

chr2_47163485_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-4295

chr2

47163483

47163489

7mer-m8

47163482

47163499

152

-12.01

ADediting_878945

chr2_47163485_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-454-3p

chr2

47163483

47163489

7mer-m8

47163482

47163506

155

-14.71

ADediting_878945

chr2_47163485_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-504-3p

chr2

47163480

47163487

8mer-1a

47163480

47163503

149

-22.96

ADediting_878948

chr2_47163500_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-6787-3p

chr2

47163498

47163504

7mer-1a

47163498

47163520

147

-28.34

ADediting_878949

chr2_47163541_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-1343-3p

chr2

47163541

47164165

7mer-m8

47163540

47164180

144

-22.82

ADediting_878949

chr2_47163541_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-5571-5p

chr2

47163536

47163542

7mer-m8

47163535

47164173

153

-18.12

ADediting_878949

chr2_47163541_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-6783-3p

chr2

47163541

47164165

7mer-m8

47163540

47164179

140

-16.43

ADediting_878982

chr2_47164175_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-4327

chr2

47164173

47164179

7mer-m8

47164172

47164191

147

-18.99

ADediting_878982

chr2_47164175_-

ENSG00000143933.18

ENST00000670593.1

CALM2-216

hsa-miR-6516-5p

chr2

47164175

47164181

7mer-m8

47164174

47164196

152

-15.02

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1337757

chr7_5495852_-

ENSG00000143933.18

ENST00000272298.12

CALM2-201

hsa-miR-589-3p

chr2

47160153

47160159

7mer-m8

47160152

47160175

150

-14.85

ADediting_1337757

chr7_5495852_-

ENSG00000143933.18

ENST00000628793.2

CALM2-209

hsa-miR-589-3p

chr2

47160153

47160159

7mer-m8

47160152

47160175

150

-14.85

ADediting_1337757

chr7_5495852_-

ENSG00000143933.18

ENST00000654798.1

CALM2-211

hsa-miR-589-3p

chr2

47160153

47160159

7mer-m8

47160152

47160175

150

-14.85

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CALM2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000670593.1	lncRNA
ENST00000409563.5	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_878992	ENST00000409563.5	chr2_47167502_-	291	-204.70	-201.40	-208.70
ADediting_878993	ENST00000409563.5	chr2_47167511_-	282	-201.00	-201.40	-208.70
ADediting_878994	ENST00000409563.5	chr2_47167570_-	223	-205.10	-201.40	-208.70
ADediting_1637778	ENST00000409563.5	chr2_47167611_-	182	-204.20	-201.40	-208.70

RNA A-to-I editing in lncRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1563583	ENST00000670593.1	chr2_47163459_-	143	-538.50	-538.50	-540.00
ADediting_878944	ENST00000670593.1	chr2_47163460_-	142	-540.90	-538.50	-540.00
ADediting_878945	ENST00000670593.1	chr2_47163485_-	117	-538.10	-538.50	-540.00
ADediting_878946	ENST00000670593.1	chr2_47163493_-	109	-543.90	-538.50	-540.00
ADediting_878947	ENST00000670593.1	chr2_47163498_-	104	-538.80	-538.50	-540.00
ADediting_878948	ENST00000670593.1	chr2_47163500_-	102	-537.60	-538.50	-540.00
ADediting_878949	ENST00000670593.1	chr2_47163541_-	61	-537.00	-538.50	-540.00
ADediting_878982	ENST00000670593.1	chr2_47164175_-	45	-538.20	-538.50	-540.00
ADediting_878983	ENST00000670593.1	chr2_47164191_-	29	-538.50	-538.50	-540.00

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Relation with ADAR for CALM2

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_878947	chr2_47163498_-	1.38198725435195e-06	0.382291462211253	2.06542083760806e-05	0.340066165123824	0.145073222001966	0.119549278471839
DLPFC	ADediting_878952	chr2_47163570_-	2.4845390750678e-07	0.287938371348154	0.000268559682363429	0.205574160485812	4.29090354306324e-09	0.32571606616249
DLPFC	ADediting_878959	chr2_47163614_-	0.0176561731685715	0.134692659595161	0.462256032914519	0.041903917243427	1.74525297168908e-13	0.402236425144035
DLPFC	ADediting_878967	chr2_47163678_-	2.48900562028019e-08	0.310003330490593	2.56413750396307e-08	0.309729525324005	2.2361819295741e-05	0.23829494226282
CER	ADediting_878967	chr2_47163678_-	1.31821835689833e-06	0.382978562431906	0.000391899455133394	0.285815306930479	0.925593435991854	-0.00768950603855169
DLPFC	ADediting_878969	chr2_47163704_-	3.42412833650661e-09	0.327669064627837	9.50588960400062e-09	0.318718818008797	1.53415291036027e-05	0.242865777078265
DLPFC	ADediting_878970	chr2_47163705_-	8.40655670177183e-10	0.33952447523967	4.65035112446236e-09	0.325016450672117	0.126707276638092	0.0869269462357024
CER	ADediting_878970	chr2_47163705_-	1.80465750602592e-06	0.378380669108342	8.27468225254755e-05	0.315776334864609	0.693550013610999	0.0324362722312768
DLPFC	ADediting_878974	chr2_47163867_-	0.046529523897705	0.113149864120512	0.967965840144893	-0.00229016401245549	5.89895075976309e-15	0.42398002039159
CER	ADediting_878974	chr2_47163867_-	0.000127874396292385	0.307711212159442	0.000145693161062963	0.305248131008152	0.903440622768547	-0.00998873631688265
DLPFC	ADediting_878981	chr2_47164048_-	0.0725385762688076	0.102135949646785	0.607625136988157	0.0292749417507584	9.85865211255417e-12	0.374080973205843
DLPFC	ADediting_878989	chr2_47164534_-	0.0075075150827552	0.151575861352585	0.571434576858568	0.032265204686883	2.41789057242627e-12	0.384198461076228
DLPFC	ADediting_878990	chr2_47164570_-	0.00022109094610301	0.208318540298766	0.0259553508806892	0.126480840790714	2.8610346323087e-08	0.30871838196229
DLPFC	ADediting_878998	chr2_47168504_-	0.0182626303311831	0.133989454048655	0.934195160299338	-0.00470853451713891	1.68170822620566e-12	0.386756498115967
DLPFC	ADediting_879004	chr2_47168573_-	0.261828623180125	0.0639228708802083	0.111488906836271	-0.0905732072660633	5.70666922285788e-13	0.394242110591398
TCX	ADediting_879004	chr2_47168573_-	0.111528824094894	0.130469326659126	0.132570857106489	-0.123366835875211	2.05439415993961e-05	0.34015600263757
STG	ADediting_879007	chr2_47168611_-	0.19707649103514	0.142156491719676	0.00207330261633555	0.331419245293366	0.362267638200691	-0.100659477934636
CER	ADediting_879008	chr2_47168621_-	9.35561186197254e-05	0.313524669797667	9.85454300590371e-05	0.312566375792935	0.0874372695766641	-0.140028312191324
STG	ADediting_879025	chr2_47169005_-	0.000127253456970834	0.406000542417948	0.00624279340723721	0.29609965579387	0.209506419052933	0.138336818164293
PCC	ADediting_879030	chr2_47169359_-	9.05851096742775e-09	0.400925855511346	1.41898454365128e-08	0.396041712420393	0.0473631657941148	0.143685370393698
CER	ADediting_879030	chr2_47169359_-	1.61308066433685e-06	0.380031560938757	0.00088799170880998	0.268628560805445	0.591327159368648	0.0441870517322001

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	4.02494708976886e-62	0.77023284202031	1.02130684675173e-66	0.787536773656735	0.777668093281601	0.0161009293542649
AC	1.1918067953463e-86	0.890199527421125	2.47406190581849e-73	0.856918398333395	5.52615679843553e-10	0.379465943382984
PCC	1.11750596859684e-32	0.726943691578267	8.20819585688488e-37	0.757265661132522	0.118215475088234	0.113424066826697
CER	5.09038325429654e-23	0.695700464931509	6.73973684301937e-15	0.580694080928404	0.144169894082793	0.119816525270591
TCX	1.77508349967423e-29	0.759892576414215	4.75595484258713e-16	0.600213181919914	0.501899295298771	0.0552483800345819
FP	1.97391139441062e-07	0.377989979956222	9.19644717079829e-15	0.538324074324821	0.0404323292268139	-0.153770469696646
IFG	0.101617287815715	0.335023187724825	0.692573422323564	0.0831949817674216	0.0263283393741846	-0.443629587002497
PG	2.59991101747349e-39	0.780012049777147	8.14138332821033e-25	0.661924379411415	0.149147750379172	-0.106189330695402
STG	8.96182579348471e-14	0.70304051236826	3.12399873394846e-15	0.730480724378967	0.249250392490519	-0.127106157433422

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Relation with AD stages for CALM2

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
IFG	ADediting_879005	chr2_47168576_-	0.0419385102905818	0.409742452809865
IFG	ADediting_879008	chr2_47168621_-	0.00444743469804583	0.549391048271317
STG	ADediting_878995	chr2_47167900_-	0.00105701469285775	-0.351131672228226
STG	ADediting_879007	chr2_47168611_-	0.00346282797478163	-0.31550208273009

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	0.000376471144059824	0.336082452234921
IFG	0.0410661766436839	-0.411343077573957

Top

RelatedDrugs for CALM2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CALM2	P0DP24	DB11348	Calcium Phosphate	Calmodulin-2 {ECO:0000312\|HGNC:HGNC:1445}	small molecule	approved
CALM2	P0DP24	DB11093	Calcium Citrate	Calmodulin-2 {ECO:0000312\|HGNC:HGNC:1445}	small molecule	approved\|investigational

Top

RelatedDiseases for CALM2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CALM2	C4015695	LONG QT SYNDROME 15	6	CTD_human;UNIPROT
CALM2	C0011570	Mental Depression	5	PSYGENET
CALM2	C0011581	Depressive disorder	5	PSYGENET
CALM2	C1631597	VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)	3	GENOMICS_ENGLAND;ORPHANET
CALM2	C0005586	Bipolar Disorder	2	PSYGENET
CALM2	C0006868	Cannabis Abuse	1	CTD_human
CALM2	C0006870	Cannabis Dependence	1	CTD_human
CALM2	C0009171	Cocaine Abuse	1	CTD_human
CALM2	C0018614	Hashish Abuse	1	CTD_human
CALM2	C0024809	Marijuana Abuse	1	CTD_human
CALM2	C0031391	Phencyclidine Abuse	1	CTD_human
CALM2	C0236735	Cannabis-Related Disorder	1	CTD_human
CALM2	C0236736	Cocaine-Related Disorders	1	CTD_human
CALM2	C0236742	Phencyclidine-Related Disorders	1	CTD_human
CALM2	C0588008	Severe depression	1	PSYGENET
CALM2	C0600427	Cocaine Dependence	1	CTD_human

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Gene summary for CALM2

RNA A-to-I events for CALM2

RNA editing positional annotations for CALM2 using Annovar

RNA A-to-I editing events in the alternative splicing sites for CALM2

Differntial gene expression between RNA A-to-I edited versus non-edited samples for CALM2

Protein coding region RNA A-to-I editings for CALM2

The effects of the RNA editing to the miRNA binding sites for CALM2

The effects of the RNA editing to the stability of the RNA structures for CALM2

Relation with ADAR for CALM2

Relation with AD stages for CALM2

RelatedDrugs for CALM2

RelatedDiseases for CALM2

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene