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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RMI1 |
 Gene summary |
| Gene information | Gene symbol | RMI1 | Gene ID | 80010 |
| Gene name | RecQ mediated genome instability 1 | |
| Synonyms | BLAP75|C9orf76|FAAP75 | |
| Cytomap | 9q21.32 | |
| Type of gene | protein-coding | |
| Description | recQ-mediated genome instability protein 1BLM-associated polypeptide, 75 kDaBLM-associated protein 75 kDaRMI1, RecQ mediated genome instability 1, homologhomolog of yeast RecQ-mediated genome instability 1 (RMI1) | |
| Modification date | 20200313 | |
| UniProtAcc | Q9H9A7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for RMI1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1475735(83987095, +), ADediting_1475736(83987164, +), ADediting_1475737(83987180, +), ADediting_1475738(83987321, +), ADediting_1475739(83988340, +), ADediting_1475740(83989351, +), ADediting_1475741(83989531, +), ADediting_1475742(83989606, +), ADediting_1475743(83990245, +), ADediting_1475744(83990261, +), ADediting_1475745(83990354, +), ADediting_1475746(83990356, +), ADediting_1475747(83990381, +), ADediting_1475748(83990389, +), ADediting_1475749(83990395, +), ADediting_1475750(83990399, +), ADediting_1475751(83990416, +), ADediting_1475752(83990430, +), ADediting_1475753(83990431, +), ADediting_1475754(83990435, +), ADediting_1475755(83998879, +), ADediting_1475756(83999010, +), ADediting_1475757(83999020, +), ADediting_1475758(83999047, +), ADediting_1475759(84003095, +), ADediting_1475760(84003144, +), ADediting_1594211(83982547, +), ADediting_1594212(83982574, +), ADediting_1594213(83988348, +), ADediting_1594214(83988373, +), ADediting_1673746(83988019, +), |
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RNA editing positional annotations for RMI1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1475735 | chr9_83987095_+ | intronic |
| ADediting_1475736 | chr9_83987164_+ | intronic |
| ADediting_1475737 | chr9_83987180_+ | intronic |
| ADediting_1475738 | chr9_83987321_+ | intronic |
| ADediting_1475739 | chr9_83988340_+ | intronic |
| ADediting_1475740 | chr9_83989351_+ | intronic |
| ADediting_1475741 | chr9_83989531_+ | intronic |
| ADediting_1475742 | chr9_83989606_+ | intronic |
| ADediting_1475743 | chr9_83990245_+ | intronic |
| ADediting_1475744 | chr9_83990261_+ | intronic |
| ADediting_1475745 | chr9_83990354_+ | intronic |
| ADediting_1475746 | chr9_83990356_+ | intronic |
| ADediting_1475747 | chr9_83990381_+ | intronic |
| ADediting_1475748 | chr9_83990389_+ | intronic |
| ADediting_1475749 | chr9_83990395_+ | intronic |
| ADediting_1475750 | chr9_83990399_+ | intronic |
| ADediting_1475751 | chr9_83990416_+ | intronic |
| ADediting_1475752 | chr9_83990430_+ | intronic |
| ADediting_1475753 | chr9_83990431_+ | intronic |
| ADediting_1475754 | chr9_83990435_+ | intronic |
| ADediting_1475755 | chr9_83998879_+ | intronic |
| ADediting_1475756 | chr9_83999010_+ | intronic |
| ADediting_1475757 | chr9_83999020_+ | intronic |
| ADediting_1475758 | chr9_83999047_+ | intronic |
| ADediting_1475759 | chr9_84003095_+ | UTR3 |
| ADediting_1475760 | chr9_84003144_+ | UTR3 |
| ADediting_1594211 | chr9_83982547_+ | intronic |
| ADediting_1594212 | chr9_83982574_+ | intronic |
| ADediting_1594213 | chr9_83988348_+ | intronic |
| ADediting_1594214 | chr9_83988373_+ | intronic |
| ADediting_1673746 | chr9_83988019_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1475735 | chr9_83987095_+ | SINE | Alu | Name=AluSx |
| ADediting_1475736 | chr9_83987164_+ | SINE | Alu | Name=AluSx |
| ADediting_1475737 | chr9_83987180_+ | SINE | Alu | Name=AluSx |
| ADediting_1475738 | chr9_83987321_+ | SINE | Alu | Name=AluSx |
| ADediting_1475739 | chr9_83988340_+ | SINE | Alu | Name=AluJo |
| ADediting_1475740 | chr9_83989351_+ | LINE | L1 | Name=L1MA4 |
| ADediting_1475741 | chr9_83989531_+ | LINE | L1 | Name=L1MA4 |
| ADediting_1475742 | chr9_83989606_+ | LINE | L1 | Name=L1MA4 |
| ADediting_1475743 | chr9_83990245_+ | SINE | Alu | Name=AluSg |
| ADediting_1475744 | chr9_83990261_+ | SINE | Alu | Name=AluSg |
| ADediting_1475745 | chr9_83990354_+ | SINE | Alu | Name=AluSg |
| ADediting_1475746 | chr9_83990356_+ | SINE | Alu | Name=AluSg |
| ADediting_1475747 | chr9_83990381_+ | SINE | Alu | Name=AluSg |
| ADediting_1475748 | chr9_83990389_+ | SINE | Alu | Name=AluSg |
| ADediting_1475749 | chr9_83990395_+ | SINE | Alu | Name=AluSg |
| ADediting_1475750 | chr9_83990399_+ | SINE | Alu | Name=AluSg |
| ADediting_1475751 | chr9_83990416_+ | SINE | Alu | Name=AluSg |
| ADediting_1475752 | chr9_83990430_+ | SINE | Alu | Name=AluSg |
| ADediting_1475753 | chr9_83990431_+ | SINE | Alu | Name=AluSg |
| ADediting_1475754 | chr9_83990435_+ | SINE | Alu | Name=AluSg |
| ADediting_1475755 | chr9_83998879_+ | SINE | Alu | Name=AluSz |
| ADediting_1475756 | chr9_83999010_+ | SINE | Alu | Name=AluSz |
| ADediting_1475757 | chr9_83999020_+ | SINE | Alu | Name=AluSz |
| ADediting_1475758 | chr9_83999047_+ | SINE | Alu | Name=AluSz |
| ADediting_1475759 | chr9_84003095_+ | SINE | Alu | Name=AluJr |
| ADediting_1475760 | chr9_84003144_+ | SINE | Alu | Name=AluJr |
| ADediting_1594211 | chr9_83982547_+ | SINE | Alu | Name=AluY |
| ADediting_1594212 | chr9_83982574_+ | SINE | Alu | Name=AluY |
| ADediting_1594213 | chr9_83988348_+ | SINE | Alu | Name=AluJo |
| ADediting_1594214 | chr9_83988373_+ | SINE | Alu | Name=AluJo |
| ADediting_1673746 | chr9_83988019_+ | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for RMI1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RMI1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RMI1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RMI1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1475759 | chr9_84003095_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-508-5p | chr9 | 84003092 | 84003098 | 7mer-m8 | 84003075 | 84003099 | 152 | -24.31 |
| ADediting_1475759 | chr9_84003095_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-6512-3p | chr9 | 84003090 | 84003096 | 7mer-m8 | 84003076 | 84003097 | 146 | -18.79 |
| ADediting_1475759 | chr9_84003095_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-6720-5p | chr9 | 84003090 | 84003096 | 7mer-m8 | 84003075 | 84003097 | 151 | -25.48 |
| ADediting_1475759 | chr9_84003095_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-6849-3p | chr9 | 84003089 | 84003096 | 8mer-1a | 84003076 | 84003096 | 150 | -18.09 |
| ADediting_1475759 | chr9_84003095_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-766-3p | chr9 | 84003091 | 84003097 | 7mer-m8 | 84003073 | 84003098 | 146 | -23 |
| ADediting_1475760 | chr9_84003144_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-6078 | chr9 | 84003140 | 84003147 | 8mer-1a | 84003127 | 84003147 | 156 | -24.02 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1475759 | chr9_84003095_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-1251-5p | chr9 | 84003091 | 84003097 | 7mer-m8 | 84003076 | 84003098 | 150 | -18.45 |
| ADediting_1475759 | chr9_84003095_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-1287-3p | chr9 | 84003090 | 84003096 | 7mer-m8 | 84003071 | 84003097 | 149 | -27.03 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-589-3p | chr9 | 84003076 | 84003082 | 7mer-m8 | 84003061 | 84003083 | 152 | -17.7 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-4477b | chr9 | 84004058 | 84004065 | 8mer-1a | 84004044 | 84004065 | 154 | -11.5 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000178966.16 | ENST00000325875.7 | RMI1-201 | hsa-miR-4477b | chr9 | 84004058 | 84004065 | 8mer-1a | 84004044 | 84004065 | 154 | -11.5 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RMI1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000325875.7 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1475759 | ENST00000325875.7 | chr9_84003095_+ | 2441 | -838.80 | -836.50 | -843.40 |
| ADediting_1475760 | ENST00000325875.7 | chr9_84003144_+ | 2490 | -840.50 | -836.50 | -843.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RMI1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.20456468005176e-43 | 0.679826776011458 | 1.06785677829737e-24 | 0.538399295057672 | 0.362320154001827 | 0.051913474158142 |
| AC | 8.99654465343819e-73 | 0.8552967954293 | 4.95700834702654e-35 | 0.678177718369636 | 8.66716016659674e-24 | 0.579113212433858 |
| PCC | 2.77915972552247e-46 | 0.813079006394956 | 3.75601245299744e-40 | 0.778890313977631 | 4.35007803391699e-07 | 0.355912535819198 |
| CER | 5.14683678384452e-33 | 0.788225778940082 | 8.01693802025462e-14 | 0.561209815272199 | 0.368827018686632 | 0.0738940987734985 |
| TCX | 2.03167737762152e-34 | 0.798387706674017 | 1.53117753627783e-07 | 0.41274946602831 | 2.09756023171261e-09 | 0.464670192467922 |
| FP | 2.01851818886772e-24 | 0.668636720587183 | 8.23804180832912e-31 | 0.729210326532089 | 0.0793172100088147 | 0.131871543924088 |
| IFG | 5.99348411835422e-06 | 0.772689420362208 | 0.00795293777367703 | 0.518277506997288 | 0.276662222355392 | 0.22631779724926 |
| PG | 1.68025207051164e-42 | 0.798980866064631 | 1.31358438595229e-27 | 0.68981056393605 | 0.85008962153478 | 0.0139518303293145 |
| STG | 1.03464604945856e-13 | 0.701791766053306 | 7.5782822725922e-15 | 0.723545279179952 | 0.296313559614214 | 0.115297327944149 |
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Relation with AD stages for RMI1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 1.11121059901467e-05 | 0.412536524507931 |
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RelatedDrugs for RMI1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RMI1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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