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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ACTR5 |
 Gene summary |
| Gene information | Gene symbol | ACTR5 | Gene ID | 79913 |
| Gene name | actin related protein 5 | |
| Synonyms | Arp5|INO80M | |
| Cytomap | 20q11.23 | |
| Type of gene | protein-coding | |
| Description | actin-related protein 5ARP5 actin related protein 5 homologINO80 complex subunit MhARP5sarcoma antigen NY-SAR-16 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9H9F9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for ACTR5 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_933494(38754491, +), ADediting_933495(38754499, +), ADediting_933496(38754507, +), ADediting_933497(38754541, +), ADediting_933498(38754546, +), ADediting_933499(38760142, +), ADediting_933500(38772343, +), ADediting_933501(38772348, +), ADediting_933502(38772367, +), ADediting_933503(38772381, +), |
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RNA editing positional annotations for ACTR5 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_933494 | chr20_38754491_+ | intronic |
| ADediting_933495 | chr20_38754499_+ | intronic |
| ADediting_933496 | chr20_38754507_+ | intronic |
| ADediting_933497 | chr20_38754541_+ | intronic |
| ADediting_933498 | chr20_38754546_+ | intronic |
| ADediting_933499 | chr20_38760142_+ | intronic |
| ADediting_933500 | chr20_38772343_+ | UTR3 |
| ADediting_933501 | chr20_38772348_+ | UTR3 |
| ADediting_933502 | chr20_38772367_+ | UTR3 |
| ADediting_933503 | chr20_38772381_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_933494 | chr20_38754491_+ | SINE | Alu | Name=AluY |
| ADediting_933495 | chr20_38754499_+ | SINE | Alu | Name=AluY |
| ADediting_933496 | chr20_38754507_+ | SINE | Alu | Name=AluY |
| ADediting_933497 | chr20_38754541_+ | SINE | Alu | Name=AluY |
| ADediting_933498 | chr20_38754546_+ | SINE | Alu | Name=AluY |
| ADediting_933499 | chr20_38760142_+ | SINE | Alu | Name=AluJr |
| ADediting_933500 | chr20_38772343_+ | SINE | Alu | Name=FAM |
| ADediting_933501 | chr20_38772348_+ | SINE | Alu | Name=FAM |
| ADediting_933502 | chr20_38772367_+ | SINE | Alu | Name=FAM |
| ADediting_933503 | chr20_38772381_+ | SINE | Alu | Name=FAM |
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RNA A-to-I editing events in the alternative splicing sites for ACTR5 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ACTR5 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for ACTR5 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for ACTR5 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_933502 | chr20_38772367_+ | ENSG00000101442.10 | ENST00000243903.6 | ACTR5-201 | hsa-miR-150-5p | chr20 | 38772364 | 38772370 | 7mer-m8 | 38772350 | 38772371 | 142 | -21.37 |
| ADediting_933503 | chr20_38772381_+ | ENSG00000101442.10 | ENST00000243903.6 | ACTR5-201 | hsa-miR-196b-3p | chr20 | 38772377 | 38772383 | 7mer-m8 | 38772364 | 38772384 | 155 | -24.51 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_933501 | chr20_38772348_+ | ENSG00000101442.10 | ENST00000243903.6 | ACTR5-201 | hsa-miR-1976 | chr20 | 38772345 | 38772351 | 7mer-m8 | 38772331 | 38772352 | 152 | -25.54 |
| ADediting_933501 | chr20_38772348_+ | ENSG00000101442.10 | ENST00000243903.6 | ACTR5-201 | hsa-miR-660-3p | chr20 | 38772346 | 38772353 | 8mer-1a | 38772333 | 38772353 | 143 | -15.8 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_291761 | chr11_93733708_- | ENSG00000101442.10 | ENST00000243903.6 | ACTR5-201 | hsa-miR-1304-3p | chr20 | 38772248 | 38772254 | 7mer-m8 | 38772234 | 38772255 | 140 | -15.03 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ACTR5 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000243903.6 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_933500 | ENST00000243903.6 | chr20_38772343_+ | 2370 | -949.40 | -948.40 | -954.30 |
| ADediting_933501 | ENST00000243903.6 | chr20_38772348_+ | 2375 | -947.70 | -948.40 | -954.30 |
| ADediting_933502 | ENST00000243903.6 | chr20_38772367_+ | 2394 | -947.30 | -948.40 | -954.30 |
| ADediting_933503 | ENST00000243903.6 | chr20_38772381_+ | 2408 | -949.50 | -948.40 | -954.30 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ACTR5 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_933500 | chr20_38772343_+ | 0.000437310598923369 | 0.283574571707601 | 4.97949059945469e-05 | 0.32490525513047 | 0.220965446702195 | 0.10052389637375 |
| CER | ADediting_933502 | chr20_38772367_+ | 4.41275403490988e-05 | 0.327034790460786 | 1.50920957005342e-06 | 0.381006440820278 | 0.461777022759659 | 0.0605392285337324 |
| CER | ADediting_933503 | chr20_38772381_+ | 0.000672741058212621 | 0.274586478868503 | 0.000171237880563152 | 0.302167453388036 | 0.55775278554824 | 0.0482372648865755 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.40092991267717e-46 | 0.693687587513769 | 2.83344048947155e-71 | 0.803233074264142 | 2.09851852975395e-07 | 0.289622387574765 |
| AC | 3.55546291470224e-86 | 0.889167936009296 | 2.79604486980743e-71 | 0.85088168322293 | 1.22214302630049e-08 | 0.350544840078458 |
| PCC | 4.8909145594209e-35 | 0.744764353436395 | 1.44424165853012e-38 | 0.768920145450248 | 5.226785279085e-05 | 0.288354956604458 |
| CER | 1.24532360667301e-29 | 0.761213682987603 | 1.59475455487875e-30 | 0.768708641538918 | 0.139079655782399 | 0.121346711584153 |
| TCX | 1.94110501071311e-26 | 0.731956445749393 | 3.16553461461827e-14 | 0.568672896619559 | 0.000901020229841753 | 0.268312215726226 |
| FP | 8.83609308072965e-31 | 0.728955734208579 | 2.35430545654469e-34 | 0.756993208731151 | 0.000779675169249322 | 0.249596585152097 |
| IFG | 4.04572979267185e-07 | 0.824410419052609 | 9.45648206894098e-09 | 0.876249923284266 | 0.0535409810764163 | 0.390606228428089 |
| PG | 1.62332322910666e-17 | 0.571459599101969 | 2.1433542228574e-22 | 0.63507304331403 | 0.401134730909418 | 0.0619205167810847 |
| STG | 3.44009321818647e-20 | 0.803844036862931 | 2.60618697304023e-15 | 0.731873232063102 | 0.128385023426304 | 0.167235403812346 |
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Relation with AD stages for ACTR5 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for ACTR5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACTR5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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