ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for ZNF669

Gene summary

Gene information	Gene symbol	ZNF669
	Gene ID	79862
	Gene name	zinc finger protein 669
	Synonyms	-
	Cytomap	1q44
	Type of gene	protein-coding
	Description	zinc finger protein 669
	Modification date	20200313
	UniProtAcc	Q96BR6,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ZNF669

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_86185(247100045, -), ADediting_86186(247100113, -), ADediting_86187(247100117, -), ADediting_86188(247100133, -), ADediting_86189(247100149, -), ADediting_86190(247100159, -), ADediting_86191(247100165, -), ADediting_86192(247100256, -), ADediting_86193(247100257, -), ADediting_86194(247100358, -), ADediting_86195(247100359, -), ADediting_86196(247100392, -), ADediting_86197(247100393, -), ADediting_86198(247100414, -), ADediting_86199(247100415, -), ADediting_86200(247100417, -), ADediting_1518415(247100020, -), ADediting_1518416(247100042, -), ADediting_1518417(247100179, -), ADediting_1600138(247100180, -),

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RNA editing positional annotations for ZNF669 using Annovar

Protein coding RNA editing(s).

ADeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
ADediting_86196	chr1_247100392_-	synonymous SNV	ENST00000448299.6	c.A1119G	p.Q373Q	.	.	.
ADediting_86196	chr1_247100392_-	synonymous SNV	ENST00000343381.10	c.A1377G	p.Q459Q	.	.	.
ADediting_86197	chr1_247100393_-	nonsynonymous SNV	ENST00000448299.6	c.A1118G	p.Q373R	0.208	0.014	-0.3
ADediting_86197	chr1_247100393_-	nonsynonymous SNV	ENST00000343381.10	c.A1376G	p.Q459R	0.208	0.014	-0.3
ADediting_86198	chr1_247100414_-	nonsynonymous SNV	ENST00000448299.6	c.A1097G	p.N366S	0.679	0.004	0.38
ADediting_86198	chr1_247100414_-	nonsynonymous SNV	ENST00000343381.10	c.A1355G	p.N452S	0.679	0.004	0.38
ADediting_86199	chr1_247100415_-	nonsynonymous SNV	ENST00000448299.6	c.A1096G	p.N366D	0.607	0.063	0.13
ADediting_86199	chr1_247100415_-	nonsynonymous SNV	ENST00000343381.10	c.A1354G	p.N452D	0.607	0.063	0.13
ADediting_86200	chr1_247100417_-	nonsynonymous SNV	ENST00000448299.6	c.A1094G	p.Y365C	0.183	0.0	1.88
ADediting_86200	chr1_247100417_-	nonsynonymous SNV	ENST00000343381.10	c.A1352G	p.Y451C	0.183	0.0	1.88

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_86185	chr1_247100045_-	UTR3
ADediting_86186	chr1_247100113_-	UTR3
ADediting_86187	chr1_247100117_-	UTR3
ADediting_86188	chr1_247100133_-	UTR3
ADediting_86189	chr1_247100149_-	UTR3
ADediting_86190	chr1_247100159_-	UTR3
ADediting_86191	chr1_247100165_-	UTR3
ADediting_86192	chr1_247100256_-	UTR3
ADediting_86193	chr1_247100257_-	UTR3
ADediting_86194	chr1_247100358_-	UTR3
ADediting_86195	chr1_247100359_-	UTR3
ADediting_86196	chr1_247100392_-	exonic
ADediting_86197	chr1_247100393_-	exonic
ADediting_86198	chr1_247100414_-	exonic
ADediting_86199	chr1_247100415_-	exonic
ADediting_86200	chr1_247100417_-	exonic
ADediting_1518415	chr1_247100020_-	UTR3
ADediting_1518416	chr1_247100042_-	UTR3
ADediting_1518417	chr1_247100179_-	UTR3
ADediting_1600138	chr1_247100180_-	UTR3

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_86185	chr1_247100045_-	SINE	Alu	Name=AluY
ADediting_86186	chr1_247100113_-	SINE	Alu	Name=AluY
ADediting_86187	chr1_247100117_-	SINE	Alu	Name=AluY
ADediting_86188	chr1_247100133_-	SINE	Alu	Name=AluY
ADediting_86189	chr1_247100149_-	SINE	Alu	Name=AluY
ADediting_86190	chr1_247100159_-	SINE	Alu	Name=AluY
ADediting_86191	chr1_247100165_-	SINE	Alu	Name=AluY
ADediting_86192	chr1_247100256_-	SINE	Alu	Name=AluY
ADediting_86193	chr1_247100257_-	SINE	Alu	Name=AluY
ADediting_86194	chr1_247100358_-	SINE	Alu	Name=AluJb
ADediting_86195	chr1_247100359_-	SINE	Alu	Name=AluJb
ADediting_86196	chr1_247100392_-	SINE	Alu	Name=AluJb
ADediting_86197	chr1_247100393_-	SINE	Alu	Name=AluJb
ADediting_86198	chr1_247100414_-	SINE	Alu	Name=AluJb
ADediting_86199	chr1_247100415_-	SINE	Alu	Name=AluJb
ADediting_86200	chr1_247100417_-	SINE	Alu	Name=AluJb
ADediting_1518415	chr1_247100020_-	SINE	Alu	Name=AluY
ADediting_1518416	chr1_247100042_-	SINE	Alu	Name=AluY
ADediting_1518417	chr1_247100179_-	SINE	Alu	Name=AluY
ADediting_1600138	chr1_247100180_-	SINE	Alu	Name=AluY

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RNA A-to-I editing events in the alternative splicing sites for ZNF669

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF669

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for ZNF669

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ZNF669

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1518416	chr1_247100042_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-4746-3p	chr1	247100041	247100047	7mer-m8	247100040	247100060	144	-23.3
ADediting_1518416	chr1_247100042_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-4746-3p	chr1	247100041	247100047	7mer-m8	247100040	247100060	144	-23.3
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-412-3p	chr1	247100179	247100185	7mer-m8	247100178	247100200	151	-16.53
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-4508	chr1	247100174	247100180	7mer-m8	247100173	247100188	141	-24.29
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-6754-3p	chr1	247100179	247100185	7mer-m8	247100178	247100198	146	-15.76
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-412-3p	chr1	247100179	247100185	7mer-m8	247100178	247100200	151	-16.53
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-4508	chr1	247100174	247100180	7mer-m8	247100173	247100188	141	-24.29
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-6754-3p	chr1	247100179	247100185	7mer-m8	247100178	247100198	146	-15.76
ADediting_1600138	chr1_247100180_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-1229-3p	chr1	247100179	247100185	7mer-m8	247100178	247100200	140	-12.88
ADediting_1600138	chr1_247100180_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-1229-3p	chr1	247100179	247100185	7mer-m8	247100178	247100200	140	-12.88
ADediting_86185	chr1_247100045_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-4634	chr1	247100042	247100049	8mer-1a	247100042	247100062	150	-24.65
ADediting_86185	chr1_247100045_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-4634	chr1	247100042	247100049	8mer-1a	247100042	247100062	150	-24.65
ADediting_86188	chr1_247100133_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-6084	chr1	247100131	247100137	7mer-m8	247100130	247100147	143	-22.46
ADediting_86188	chr1_247100133_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-6084	chr1	247100131	247100137	7mer-m8	247100130	247100147	143	-22.46
ADediting_86190	chr1_247100159_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-153-5p	chr1	247100159	247100165	7mer-m8	247100158	247100180	144	-8.17
ADediting_86190	chr1_247100159_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-3680-3p	chr1	247100154	247100161	8mer-1a	247100154	247100176	140	-14.25
ADediting_86190	chr1_247100159_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-153-5p	chr1	247100159	247100165	7mer-m8	247100158	247100180	144	-8.17
ADediting_86190	chr1_247100159_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-3680-3p	chr1	247100154	247100161	8mer-1a	247100154	247100176	140	-14.25
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-222-5p	chr1	247100163	247100170	8mer-1a	247100163	247100184	140	-9.13
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-30a-3p	chr1	247100161	247100168	8mer-1a	247100161	247100185	150	-12.52
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-30d-3p	chr1	247100161	247100168	8mer-1a	247100161	247100183	149	-12.11
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-30e-3p	chr1	247100161	247100168	8mer-1a	247100161	247100185	150	-14.55
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-936	chr1	247100164	247100171	8mer-1a	247100164	247100186	159	-22.47
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-222-5p	chr1	247100163	247100170	8mer-1a	247100163	247100184	140	-9.13
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-30a-3p	chr1	247100161	247100168	8mer-1a	247100161	247100185	150	-12.52
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-30d-3p	chr1	247100161	247100168	8mer-1a	247100161	247100183	149	-12.11
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-30e-3p	chr1	247100161	247100168	8mer-1a	247100161	247100185	150	-14.55
ADediting_86191	chr1_247100165_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-936	chr1	247100164	247100171	8mer-1a	247100164	247100186	159	-22.47
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-3199	chr1	247100251	247100257	7mer-1a	247100251	247100270	141	-19.46
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-3199	chr1	247100251	247100257	7mer-1a	247100251	247100270	141	-19.46
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-513a-5p	chr1	247100256	247100262	7mer-m8	247100255	247100272	140	-16.34
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-638	chr1	247100251	247100257	7mer-1a	247100251	247100275	155	-36.23
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-513a-5p	chr1	247100256	247100262	7mer-m8	247100255	247100272	140	-16.34
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-638	chr1	247100251	247100257	7mer-1a	247100251	247100275	155	-36.23
ADediting_86194	chr1_247100358_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-5580-5p	chr1	247100353	247100359	7mer-m8	247100352	247100372	141	-14.17
ADediting_86194	chr1_247100358_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-5580-5p	chr1	247100353	247100359	7mer-m8	247100352	247100372	141	-14.17

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1518415	chr1_247100020_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-3664-5p	chr1	247100016	247100022	7mer-m8	247100015	247100036	153	-17.96
ADediting_1518415	chr1_247100020_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-6773-3p	chr1	247100018	247100025	8mer-1a	247100018	247100039	142	-16.1
ADediting_1518415	chr1_247100020_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-3664-5p	chr1	247100016	247100022	7mer-m8	247100015	247100036	153	-17.96
ADediting_1518415	chr1_247100020_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-6773-3p	chr1	247100018	247100025	8mer-1a	247100018	247100039	142	-16.1
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-193b-5p	chr1	247100175	247100181	7mer-m8	247100174	247100195	142	-20.42
ADediting_1518417	chr1_247100179_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-193b-5p	chr1	247100175	247100181	7mer-m8	247100174	247100195	142	-20.42
ADediting_1600138	chr1_247100180_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-193b-5p	chr1	247100175	247100181	7mer-m8	247100174	247100195	142	-20.42
ADediting_1600138	chr1_247100180_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-193b-5p	chr1	247100175	247100181	7mer-m8	247100174	247100195	142	-20.42
ADediting_86185	chr1_247100045_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-675-5p	chr1	247100042	247100048	7mer-1a	247100042	247100064	141	-23.91
ADediting_86185	chr1_247100045_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-675-5p	chr1	247100042	247100048	7mer-1a	247100042	247100064	141	-23.91
ADediting_86188	chr1_247100133_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-4715-3p	chr1	247100133	247100139	7mer-m8	247100132	247100152	146	-19.03
ADediting_86188	chr1_247100133_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-4727-5p	chr1	247100131	247100137	7mer-m8	247100130	247100150	155	-20.11
ADediting_86188	chr1_247100133_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-4715-3p	chr1	247100133	247100139	7mer-m8	247100132	247100152	146	-19.03
ADediting_86188	chr1_247100133_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-4727-5p	chr1	247100131	247100137	7mer-m8	247100130	247100150	155	-20.11
ADediting_86189	chr1_247100149_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-4735-5p	chr1	247100148	247100154	7mer-m8	247100147	247100168	140	-4.28
ADediting_86189	chr1_247100149_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-4735-5p	chr1	247100148	247100154	7mer-m8	247100147	247100168	140	-4.28
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-10399-5p	chr1	247100255	247100261	7mer-m8	247100254	247100274	140	-9.03
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-5089-5p	chr1	247100251	247100257	7mer-m8	247100250	247100271	148	-14.13
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-6504-3p	chr1	247100255	247100261	7mer-m8	247100254	247100275	148	-14.35
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-10399-5p	chr1	247100255	247100261	7mer-m8	247100254	247100274	140	-9.03
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-5089-5p	chr1	247100251	247100257	7mer-m8	247100250	247100271	148	-14.13
ADediting_86192	chr1_247100256_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-6504-3p	chr1	247100255	247100261	7mer-m8	247100254	247100275	148	-14.35
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-10399-5p	chr1	247100255	247100261	7mer-m8	247100254	247100274	140	-9.03
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-6504-3p	chr1	247100255	247100261	7mer-m8	247100254	247100275	148	-14.35
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000343381.10	ZNF669-201	hsa-miR-7151-3p	chr1	247100256	247100263	8mer-1a	247100256	247100275	143	-14.14
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-10399-5p	chr1	247100255	247100261	7mer-m8	247100254	247100274	140	-9.03
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-6504-3p	chr1	247100255	247100261	7mer-m8	247100254	247100275	148	-14.35
ADediting_86193	chr1_247100257_-	ENSG00000188295.14	ENST00000448299.6	ZNF669-204	hsa-miR-7151-3p	chr1	247100256	247100263	8mer-1a	247100256	247100275	143	-14.14

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1471003

chr9_63819626_+

ENSG00000188295.14

ENST00000366500.5

ZNF669-202

hsa-miR-4477b

chr1

247101155

247101161

7mer-m8

247101154

247101175

140

-12.52

ADediting_1471003

chr9_63819626_+

ENSG00000188295.14

ENST00000366501.1

ZNF669-203

hsa-miR-4477b

chr1

247101155

247101161

7mer-m8

247101154

247101175

140

-12.52

ADediting_1471004

chr9_63819627_+

ENSG00000188295.14

ENST00000366500.5

ZNF669-202

hsa-miR-4477b

chr1

247101155

247101161

7mer-m8

247101154

247101175

140

-12.52

ADediting_1471004

chr9_63819627_+

ENSG00000188295.14

ENST00000366501.1

ZNF669-203

hsa-miR-4477b

chr1

247101155

247101161

7mer-m8

247101154

247101175

140

-12.52

ADediting_291761

chr11_93733708_-

ENSG00000188295.14

ENST00000343381.10

ZNF669-201

hsa-miR-1304-3p

chr1

247100056

247100062

7mer-m8

247100055

247100076

151

-21.2

ADediting_291761

chr11_93733708_-

ENSG00000188295.14

ENST00000448299.6

ZNF669-204

hsa-miR-1304-3p

chr1

247100056

247100062

7mer-m8

247100055

247100076

151

-21.2

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZNF669

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000448299.6	protein_coding
ENST00000343381.10	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1518415	ENST00000448299.6	chr1_247100020_-	1660	-507.00	-507.70	-517.60
ADediting_1518416	ENST00000448299.6	chr1_247100042_-	1638	-507.30	-507.70	-517.60
ADediting_86185	ENST00000448299.6	chr1_247100045_-	1635	-512.10	-507.70	-517.60
ADediting_86186	ENST00000448299.6	chr1_247100113_-	1567	-507.40	-507.70	-517.60
ADediting_86187	ENST00000448299.6	chr1_247100117_-	1563	-507.70	-507.70	-517.60
ADediting_86188	ENST00000448299.6	chr1_247100133_-	1547	-507.70	-507.70	-517.60
ADediting_86189	ENST00000448299.6	chr1_247100149_-	1531	-507.30	-507.70	-517.60
ADediting_86190	ENST00000448299.6	chr1_247100159_-	1521	-507.70	-507.70	-517.60
ADediting_86191	ENST00000448299.6	chr1_247100165_-	1515	-507.70	-507.70	-517.60
ADediting_1518417	ENST00000448299.6	chr1_247100179_-	1501	-507.30	-507.70	-517.60
ADediting_1600138	ENST00000448299.6	chr1_247100180_-	1500	-508.90	-507.70	-517.60
ADediting_86192	ENST00000448299.6	chr1_247100256_-	1424	-509.60	-507.70	-517.60
ADediting_86193	ENST00000448299.6	chr1_247100257_-	1423	-509.40	-507.70	-517.60
ADediting_86194	ENST00000448299.6	chr1_247100358_-	1322	-508.50	-507.70	-517.60
ADediting_86195	ENST00000448299.6	chr1_247100359_-	1321	-507.00	-507.70	-517.60
ADediting_86196	ENST00000448299.6	chr1_247100392_-	1288	-507.30	-507.70	-517.60
ADediting_86197	ENST00000448299.6	chr1_247100393_-	1287	-507.40	-507.70	-517.60
ADediting_86198	ENST00000448299.6	chr1_247100414_-	1266	-507.70	-507.70	-517.60
ADediting_86199	ENST00000448299.6	chr1_247100415_-	1265	-507.30	-507.70	-517.60
ADediting_86200	ENST00000448299.6	chr1_247100417_-	1263	-511.40	-507.70	-517.60
ADediting_1518415	ENST00000343381.10	chr1_247100020_-	1922	-646.50	-647.20	-657.10
ADediting_1518416	ENST00000343381.10	chr1_247100042_-	1900	-646.80	-647.20	-657.10
ADediting_86185	ENST00000343381.10	chr1_247100045_-	1897	-651.60	-647.20	-657.10
ADediting_86186	ENST00000343381.10	chr1_247100113_-	1829	-646.90	-647.20	-657.10
ADediting_86187	ENST00000343381.10	chr1_247100117_-	1825	-647.20	-647.20	-657.10
ADediting_86188	ENST00000343381.10	chr1_247100133_-	1809	-647.20	-647.20	-657.10
ADediting_86189	ENST00000343381.10	chr1_247100149_-	1793	-646.80	-647.20	-657.10
ADediting_86190	ENST00000343381.10	chr1_247100159_-	1783	-647.20	-647.20	-657.10
ADediting_86191	ENST00000343381.10	chr1_247100165_-	1777	-647.20	-647.20	-657.10
ADediting_1518417	ENST00000343381.10	chr1_247100179_-	1763	-646.80	-647.20	-657.10
ADediting_1600138	ENST00000343381.10	chr1_247100180_-	1762	-648.40	-647.20	-657.10
ADediting_86192	ENST00000343381.10	chr1_247100256_-	1686	-649.10	-647.20	-657.10
ADediting_86193	ENST00000343381.10	chr1_247100257_-	1685	-648.90	-647.20	-657.10
ADediting_86194	ENST00000343381.10	chr1_247100358_-	1584	-648.00	-647.20	-657.10
ADediting_86195	ENST00000343381.10	chr1_247100359_-	1583	-646.50	-647.20	-657.10
ADediting_86196	ENST00000343381.10	chr1_247100392_-	1550	-646.80	-647.20	-657.10
ADediting_86197	ENST00000343381.10	chr1_247100393_-	1549	-646.90	-647.20	-657.10
ADediting_86198	ENST00000343381.10	chr1_247100414_-	1528	-647.20	-647.20	-657.10
ADediting_86199	ENST00000343381.10	chr1_247100415_-	1527	-646.80	-647.20	-657.10
ADediting_86200	ENST00000343381.10	chr1_247100417_-	1525	-650.90	-647.20	-657.10

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ZNF669

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_86200	chr1_247100417_-	0.158828087864735	0.115627342320832	0.00012462395405803	0.308194795587199	9.58595099040924e-06	0.352675102950035

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	6.90169801712559e-11	0.3594649791648	0.00244641575599409	0.171502333215635	1.28141770642263e-33	0.614834494073576
AC	1.12741902616303e-73	0.857895916021482	1.87466258559225e-42	0.727459732264852	3.65721468608904e-13	0.438370970524806
PCC	6.94696473248323e-48	0.820999058972098	1.3254439429658e-39	0.775502781778632	0.0131200523562509	0.179203241996183
CER	1.98109381687477e-31	0.776036120637065	5.72063827879566e-23	0.695118869303183	0.319742036078148	0.0817884376610004
TCX	4.61090211485889e-22	0.684482004301866	3.56413805700806e-07	0.401409298595328	1.99134091924043e-05	0.340678613244891
FP	2.27777594773971e-14	0.531540069961641	1.48358924105764e-21	0.635880003695567	0.27540796729541	0.0821915593564766
IFG	0.000740336524042212	0.629874874360716	0.0475238594458145	0.400072776131737	0.644327430008816	0.0970830241648148
PG	9.45058073066135e-42	0.794693997701833	3.21160772621746e-28	0.695526712724789	0.874539823026943	0.0116555771937477
STG	7.7228067357121e-17	0.757291277630751	2.32673565100383e-13	0.694625407670086	0.518181749075448	0.0714816255527029

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Relation with AD stages for ZNF669

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_86200	chr1_247100417_-	0.000536228333229553	0.327693952329909

Correlation between AD stages and this gene's expression

Tissue

P-val

Coeff.

Top

RelatedDrugs for ZNF669

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for ZNF669

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for ZNF669

RNA A-to-I events for ZNF669

RNA editing positional annotations for ZNF669 using Annovar

RNA A-to-I editing events in the alternative splicing sites for ZNF669

Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF669

Protein coding region RNA A-to-I editings for ZNF669

The effects of the RNA editing to the miRNA binding sites for ZNF669

The effects of the RNA editing to the stability of the RNA structures for ZNF669

Relation with ADAR for ZNF669

Relation with AD stages for ZNF669

RelatedDrugs for ZNF669

RelatedDiseases for ZNF669

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene