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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TTC21B |
 Gene summary |
| Gene information | Gene symbol | TTC21B | Gene ID | 79809 |
| Gene name | tetratricopeptide repeat domain 21B | |
| Synonyms | ATD4|FAP60|FLA17|IFT139|IFT139B|JBTS11|NPHP12|Nbla10696|SRTD4|THM1 | |
| Cytomap | 2q24.3 | |
| Type of gene | protein-coding | |
| Description | tetratricopeptide repeat protein 21BTPR repeat protein 21Bintraflagellar transport 139 homologputative protein product of Nbla10696 | |
| Modification date | 20200313 | |
| UniProtAcc | Q7Z4L5, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for TTC21B |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_823036(165858570, -), ADediting_823037(165858646, -), ADediting_823038(165858647, -), ADediting_823039(165859802, -), ADediting_823040(165859807, -), ADediting_823041(165859865, -), ADediting_823042(165859884, -), ADediting_823043(165859901, -), ADediting_823044(165859905, -), ADediting_823045(165859906, -), ADediting_823046(165859934, -), ADediting_823047(165859954, -), ADediting_823048(165859955, -), ADediting_823049(165860558, -), ADediting_823050(165861924, -), ADediting_823051(165861942, -), ADediting_823052(165861953, -), ADediting_823053(165861994, -), ADediting_823054(165861999, -), ADediting_823055(165862000, -), ADediting_823056(165862001, -), ADediting_823057(165862005, -), ADediting_823058(165862006, -), ADediting_823059(165862016, -), ADediting_823060(165862059, -), ADediting_823061(165862071, -), ADediting_823062(165862076, -), ADediting_823063(165862080, -), ADediting_823064(165862081, -), ADediting_823065(165862167, -), ADediting_823066(165865035, -), ADediting_823067(165865242, -), ADediting_823068(165865247, -), ADediting_823069(165865250, -), ADediting_823070(165865302, -), ADediting_823071(165865306, -), ADediting_823072(165865316, -), ADediting_823073(165865347, -), ADediting_823074(165865348, -), ADediting_823075(165865351, -), ADediting_823076(165865356, -), ADediting_823077(165865360, -), ADediting_823078(165865374, -), ADediting_823079(165865381, -), ADediting_823080(165865451, -), ADediting_823081(165869882, -), ADediting_823082(165869891, -), ADediting_823083(165869925, -), ADediting_823084(165869948, -), ADediting_823085(165869958, -), ADediting_823086(165869994, -), ADediting_823087(165869997, -), ADediting_823088(165869998, -), ADediting_823089(165869999, -), ADediting_823090(165870002, -), ADediting_823091(165870061, -), ADediting_823092(165870085, -), ADediting_823093(165870092, -), ADediting_823094(165870094, -), ADediting_823095(165870378, -), ADediting_823096(165870381, -), ADediting_823097(165870389, -), ADediting_823098(165873063, -), ADediting_823099(165874084, -), ADediting_823100(165874102, -), ADediting_823101(165874103, -), ADediting_823102(165874157, -), ADediting_823103(165874165, -), ADediting_823104(165874179, -), ADediting_823105(165874182, -), ADediting_823106(165874188, -), ADediting_823107(165874198, -), ADediting_823108(165874222, -), ADediting_823109(165874234, -), ADediting_823110(165874246, -), ADediting_823111(165874283, -), ADediting_823112(165874302, -), ADediting_823113(165874338, -), ADediting_823114(165874340, -), ADediting_823115(165878948, -), ADediting_823116(165878961, -), ADediting_823117(165910159, -), ADediting_823118(165910214, -), ADediting_823119(165921874, -), ADediting_823120(165921890, -), ADediting_823121(165921891, -), ADediting_823122(165921901, -), ADediting_823123(165921904, -), ADediting_823124(165922017, -), ADediting_823125(165923062, -), ADediting_823126(165923079, -), ADediting_823127(165923080, -), ADediting_823128(165923124, -), ADediting_823129(165923131, -), ADediting_823130(165923163, -), ADediting_1561236(165858787, -), ADediting_1561237(165861793, -), ADediting_1561238(165861832, -), ADediting_1561239(165923176, -), ADediting_1634005(165862031, -), ADediting_1634006(165911800, -), |
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RNA editing positional annotations for TTC21B using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_823036 | chr2_165858570_- | intronic |
| ADediting_823037 | chr2_165858646_- | intronic |
| ADediting_823038 | chr2_165858647_- | intronic |
| ADediting_823039 | chr2_165859802_- | intronic |
| ADediting_823040 | chr2_165859807_- | intronic |
| ADediting_823041 | chr2_165859865_- | intronic |
| ADediting_823042 | chr2_165859884_- | intronic |
| ADediting_823043 | chr2_165859901_- | intronic |
| ADediting_823044 | chr2_165859905_- | intronic |
| ADediting_823045 | chr2_165859906_- | intronic |
| ADediting_823046 | chr2_165859934_- | intronic |
| ADediting_823047 | chr2_165859954_- | intronic |
| ADediting_823048 | chr2_165859955_- | intronic |
| ADediting_823049 | chr2_165860558_- | intronic |
| ADediting_823050 | chr2_165861924_- | intronic |
| ADediting_823051 | chr2_165861942_- | intronic |
| ADediting_823052 | chr2_165861953_- | intronic |
| ADediting_823053 | chr2_165861994_- | intronic |
| ADediting_823054 | chr2_165861999_- | intronic |
| ADediting_823055 | chr2_165862000_- | intronic |
| ADediting_823056 | chr2_165862001_- | intronic |
| ADediting_823057 | chr2_165862005_- | intronic |
| ADediting_823058 | chr2_165862006_- | intronic |
| ADediting_823059 | chr2_165862016_- | intronic |
| ADediting_823060 | chr2_165862059_- | intronic |
| ADediting_823061 | chr2_165862071_- | intronic |
| ADediting_823062 | chr2_165862076_- | intronic |
| ADediting_823063 | chr2_165862080_- | intronic |
| ADediting_823064 | chr2_165862081_- | intronic |
| ADediting_823065 | chr2_165862167_- | intronic |
| ADediting_823066 | chr2_165865035_- | UTR3 |
| ADediting_823067 | chr2_165865242_- | intronic |
| ADediting_823068 | chr2_165865247_- | intronic |
| ADediting_823069 | chr2_165865250_- | intronic |
| ADediting_823070 | chr2_165865302_- | intronic |
| ADediting_823071 | chr2_165865306_- | intronic |
| ADediting_823072 | chr2_165865316_- | intronic |
| ADediting_823073 | chr2_165865347_- | intronic |
| ADediting_823074 | chr2_165865348_- | intronic |
| ADediting_823075 | chr2_165865351_- | intronic |
| ADediting_823076 | chr2_165865356_- | intronic |
| ADediting_823077 | chr2_165865360_- | intronic |
| ADediting_823078 | chr2_165865374_- | intronic |
| ADediting_823079 | chr2_165865381_- | intronic |
| ADediting_823080 | chr2_165865451_- | intronic |
| ADediting_823081 | chr2_165869882_- | intronic |
| ADediting_823082 | chr2_165869891_- | intronic |
| ADediting_823083 | chr2_165869925_- | intronic |
| ADediting_823084 | chr2_165869948_- | intronic |
| ADediting_823085 | chr2_165869958_- | intronic |
| ADediting_823086 | chr2_165869994_- | intronic |
| ADediting_823087 | chr2_165869997_- | intronic |
| ADediting_823088 | chr2_165869998_- | intronic |
| ADediting_823089 | chr2_165869999_- | intronic |
| ADediting_823090 | chr2_165870002_- | intronic |
| ADediting_823091 | chr2_165870061_- | intronic |
| ADediting_823092 | chr2_165870085_- | intronic |
| ADediting_823093 | chr2_165870092_- | intronic |
| ADediting_823094 | chr2_165870094_- | intronic |
| ADediting_823095 | chr2_165870378_- | intronic |
| ADediting_823096 | chr2_165870381_- | intronic |
| ADediting_823097 | chr2_165870389_- | intronic |
| ADediting_823098 | chr2_165873063_- | intronic |
| ADediting_823099 | chr2_165874084_- | UTR3 |
| ADediting_823100 | chr2_165874102_- | UTR3 |
| ADediting_823101 | chr2_165874103_- | UTR3 |
| ADediting_823102 | chr2_165874157_- | UTR3 |
| ADediting_823103 | chr2_165874165_- | UTR3 |
| ADediting_823104 | chr2_165874179_- | UTR3 |
| ADediting_823105 | chr2_165874182_- | UTR3 |
| ADediting_823106 | chr2_165874188_- | UTR3 |
| ADediting_823107 | chr2_165874198_- | UTR3 |
| ADediting_823108 | chr2_165874222_- | UTR3 |
| ADediting_823109 | chr2_165874234_- | UTR3 |
| ADediting_823110 | chr2_165874246_- | UTR3 |
| ADediting_823111 | chr2_165874283_- | UTR3 |
| ADediting_823112 | chr2_165874302_- | UTR3 |
| ADediting_823113 | chr2_165874338_- | UTR3 |
| ADediting_823114 | chr2_165874340_- | UTR3 |
| ADediting_823115 | chr2_165878948_- | intronic |
| ADediting_823116 | chr2_165878961_- | intronic |
| ADediting_823117 | chr2_165910159_- | intronic |
| ADediting_823118 | chr2_165910214_- | intronic |
| ADediting_823119 | chr2_165921874_- | intronic |
| ADediting_823120 | chr2_165921890_- | intronic |
| ADediting_823121 | chr2_165921891_- | intronic |
| ADediting_823122 | chr2_165921901_- | intronic |
| ADediting_823123 | chr2_165921904_- | intronic |
| ADediting_823124 | chr2_165922017_- | intronic |
| ADediting_823125 | chr2_165923062_- | intronic |
| ADediting_823126 | chr2_165923079_- | intronic |
| ADediting_823127 | chr2_165923080_- | intronic |
| ADediting_823128 | chr2_165923124_- | intronic |
| ADediting_823129 | chr2_165923131_- | intronic |
| ADediting_823130 | chr2_165923163_- | intronic |
| ADediting_1561236 | chr2_165858787_- | intronic |
| ADediting_1561237 | chr2_165861793_- | intronic |
| ADediting_1561238 | chr2_165861832_- | intronic |
| ADediting_1561239 | chr2_165923176_- | intronic |
| ADediting_1634005 | chr2_165862031_- | intronic |
| ADediting_1634006 | chr2_165911800_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_823036 | chr2_165858570_- | LTR | ERVL-MaLR | Name=THE1D |
| ADediting_823037 | chr2_165858646_- | LTR | ERVL-MaLR | Name=THE1D |
| ADediting_823038 | chr2_165858647_- | LTR | ERVL-MaLR | Name=THE1D |
| ADediting_823039 | chr2_165859802_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823040 | chr2_165859807_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823041 | chr2_165859865_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823042 | chr2_165859884_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823043 | chr2_165859901_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823044 | chr2_165859905_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823045 | chr2_165859906_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823046 | chr2_165859934_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823047 | chr2_165859954_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823048 | chr2_165859955_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823049 | chr2_165860558_- | LTR | ERVL-MaLR | Name=THE1B-int |
| ADediting_823050 | chr2_165861924_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823051 | chr2_165861942_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823052 | chr2_165861953_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823053 | chr2_165861994_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823054 | chr2_165861999_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823055 | chr2_165862000_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823056 | chr2_165862001_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823057 | chr2_165862005_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823058 | chr2_165862006_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823059 | chr2_165862016_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823060 | chr2_165862059_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823061 | chr2_165862071_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823062 | chr2_165862076_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823063 | chr2_165862080_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823064 | chr2_165862081_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823065 | chr2_165862167_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_823067 | chr2_165865242_- | SINE | Alu | Name=AluSq2 |
| ADediting_823068 | chr2_165865247_- | SINE | Alu | Name=AluSq2 |
| ADediting_823069 | chr2_165865250_- | SINE | Alu | Name=AluSq2 |
| ADediting_823070 | chr2_165865302_- | SINE | Alu | Name=AluSq2 |
| ADediting_823071 | chr2_165865306_- | SINE | Alu | Name=AluSq2 |
| ADediting_823072 | chr2_165865316_- | SINE | Alu | Name=AluSq2 |
| ADediting_823073 | chr2_165865347_- | SINE | Alu | Name=AluSq2 |
| ADediting_823074 | chr2_165865348_- | SINE | Alu | Name=AluSq2 |
| ADediting_823075 | chr2_165865351_- | SINE | Alu | Name=AluSq2 |
| ADediting_823076 | chr2_165865356_- | SINE | Alu | Name=AluSq2 |
| ADediting_823077 | chr2_165865360_- | SINE | Alu | Name=AluSq2 |
| ADediting_823078 | chr2_165865374_- | SINE | Alu | Name=AluSq2 |
| ADediting_823079 | chr2_165865381_- | SINE | Alu | Name=AluSq2 |
| ADediting_823080 | chr2_165865451_- | SINE | Alu | Name=AluSq2 |
| ADediting_823081 | chr2_165869882_- | SINE | Alu | Name=AluSx3 |
| ADediting_823082 | chr2_165869891_- | SINE | Alu | Name=AluSx3 |
| ADediting_823083 | chr2_165869925_- | SINE | Alu | Name=AluSx3 |
| ADediting_823084 | chr2_165869948_- | SINE | Alu | Name=AluSx3 |
| ADediting_823085 | chr2_165869958_- | SINE | Alu | Name=AluSx3 |
| ADediting_823086 | chr2_165869994_- | SINE | Alu | Name=AluSx3 |
| ADediting_823087 | chr2_165869997_- | SINE | Alu | Name=AluSx3 |
| ADediting_823088 | chr2_165869998_- | SINE | Alu | Name=AluSx3 |
| ADediting_823089 | chr2_165869999_- | SINE | Alu | Name=AluSx3 |
| ADediting_823090 | chr2_165870002_- | SINE | Alu | Name=AluSx3 |
| ADediting_823091 | chr2_165870061_- | SINE | Alu | Name=AluSx3 |
| ADediting_823092 | chr2_165870085_- | SINE | Alu | Name=AluSx3 |
| ADediting_823093 | chr2_165870092_- | SINE | Alu | Name=AluSx3 |
| ADediting_823094 | chr2_165870094_- | SINE | Alu | Name=AluSx3 |
| ADediting_823095 | chr2_165870378_- | LINE | L1 | Name=L1ME4a |
| ADediting_823096 | chr2_165870381_- | LINE | L1 | Name=L1ME4a |
| ADediting_823097 | chr2_165870389_- | LINE | L1 | Name=L1ME4a |
| ADediting_823098 | chr2_165873063_- | SINE | Alu | Name=AluSz6 |
| ADediting_823099 | chr2_165874084_- | SINE | Alu | Name=AluSc8 |
| ADediting_823100 | chr2_165874102_- | SINE | Alu | Name=AluSc8 |
| ADediting_823101 | chr2_165874103_- | SINE | Alu | Name=AluSc8 |
| ADediting_823102 | chr2_165874157_- | SINE | Alu | Name=AluSc8 |
| ADediting_823103 | chr2_165874165_- | SINE | Alu | Name=AluSc8 |
| ADediting_823104 | chr2_165874179_- | SINE | Alu | Name=AluSc8 |
| ADediting_823105 | chr2_165874182_- | SINE | Alu | Name=AluSc8 |
| ADediting_823106 | chr2_165874188_- | SINE | Alu | Name=AluSc8 |
| ADediting_823107 | chr2_165874198_- | SINE | Alu | Name=AluSc8 |
| ADediting_823108 | chr2_165874222_- | SINE | Alu | Name=AluSc8 |
| ADediting_823109 | chr2_165874234_- | SINE | Alu | Name=AluSc8 |
| ADediting_823110 | chr2_165874246_- | SINE | Alu | Name=AluSc8 |
| ADediting_823111 | chr2_165874283_- | SINE | Alu | Name=AluSc8 |
| ADediting_823112 | chr2_165874302_- | SINE | Alu | Name=AluSc8 |
| ADediting_823113 | chr2_165874338_- | SINE | Alu | Name=AluSc8 |
| ADediting_823114 | chr2_165874340_- | SINE | Alu | Name=AluSc8 |
| ADediting_823115 | chr2_165878948_- | SINE | Alu | Name=AluSx1 |
| ADediting_823116 | chr2_165878961_- | SINE | Alu | Name=AluSx1 |
| ADediting_823117 | chr2_165910159_- | SINE | Alu | Name=AluY |
| ADediting_823118 | chr2_165910214_- | SINE | Alu | Name=AluY |
| ADediting_823119 | chr2_165921874_- | LINE | L1 | Name=L1PB1 |
| ADediting_823120 | chr2_165921890_- | LINE | L1 | Name=L1PB1 |
| ADediting_823121 | chr2_165921891_- | LINE | L1 | Name=L1PB1 |
| ADediting_823122 | chr2_165921901_- | LINE | L1 | Name=L1PB1 |
| ADediting_823123 | chr2_165921904_- | LINE | L1 | Name=L1PB1 |
| ADediting_823124 | chr2_165922017_- | LINE | L1 | Name=L1PB1 |
| ADediting_823125 | chr2_165923062_- | LINE | L1 | Name=L1PB3 |
| ADediting_823126 | chr2_165923079_- | LINE | L1 | Name=L1PB3 |
| ADediting_823127 | chr2_165923080_- | LINE | L1 | Name=L1PB3 |
| ADediting_823128 | chr2_165923124_- | LINE | L1 | Name=L1PB3 |
| ADediting_823129 | chr2_165923131_- | LINE | L1 | Name=L1PB3 |
| ADediting_823130 | chr2_165923163_- | LINE | L1 | Name=L1PB3 |
| ADediting_1561236 | chr2_165858787_- | LTR | ERVL-MaLR | Name=THE1D |
| ADediting_1561237 | chr2_165861793_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1561238 | chr2_165861832_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1561239 | chr2_165923176_- | LINE | L1 | Name=L1PB3 |
| ADediting_1634005 | chr2_165862031_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1634006 | chr2_165911800_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for TTC21B |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TTC21B |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TTC21B |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TTC21B |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_823100 | chr2_165874102_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-3189-3p | chr2 | 165874101 | 165874107 | 7mer-m8 | 165874100 | 165874123 | 149 | -26.69 |
| ADediting_823100 | chr2_165874102_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6813-3p | chr2 | 165874100 | 165874106 | 7mer-m8 | 165874099 | 165874119 | 140 | -12.15 |
| ADediting_823101 | chr2_165874103_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-326 | chr2 | 165874101 | 165874107 | 7mer-m8 | 165874100 | 165874119 | 140 | -14.6 |
| ADediting_823101 | chr2_165874103_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-330-5p | chr2 | 165874101 | 165874107 | 7mer-m8 | 165874100 | 165874121 | 140 | -21.93 |
| ADediting_823101 | chr2_165874103_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-4314 | chr2 | 165874102 | 165874108 | 7mer-m8 | 165874101 | 165874118 | 140 | -21.61 |
| ADediting_823101 | chr2_165874103_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-514a-5p | chr2 | 165874100 | 165874106 | 7mer-m8 | 165874099 | 165874122 | 146 | -18.62 |
| ADediting_823102 | chr2_165874157_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-3190-5p | chr2 | 165874152 | 165874158 | 7mer-m8 | 165874151 | 165874169 | 152 | -22.63 |
| ADediting_823102 | chr2_165874157_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-548s | chr2 | 165874153 | 165874159 | 7mer-m8 | 165874152 | 165874176 | 153 | -14.49 |
| ADediting_823107 | chr2_165874198_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-34a-3p | chr2 | 165874195 | 165874201 | 7mer-m8 | 165874194 | 165874216 | 143 | -9.63 |
| ADediting_823108 | chr2_165874222_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-938 | chr2 | 165874218 | 165874225 | 8mer-1a | 165874218 | 165874239 | 140 | -21.28 |
| ADediting_823109 | chr2_165874234_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-4691-3p | chr2 | 165874230 | 165874236 | 7mer-m8 | 165874229 | 165874255 | 148 | -24.72 |
| ADediting_823110 | chr2_165874246_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6089 | chr2 | 165874241 | 165874247 | 7mer-m8 | 165874240 | 165874263 | 160 | -37.26 |
| ADediting_823111 | chr2_165874283_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-17-3p | chr2 | 165874283 | 165874289 | 7mer-m8 | 165874282 | 165874302 | 153 | -19.22 |
| ADediting_823111 | chr2_165874283_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-485-5p | chr2 | 165874279 | 165874285 | 7mer-m8 | 165874278 | 165874298 | 153 | -17.86 |
| ADediting_823111 | chr2_165874283_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6884-5p | chr2 | 165874279 | 165874285 | 7mer-m8 | 165874278 | 165874300 | 146 | -20.16 |
| ADediting_823113 | chr2_165874338_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-1291 | chr2 | 165874335 | 165874341 | 7mer-m8 | 165874334 | 165874359 | 153 | -19.13 |
| ADediting_823113 | chr2_165874338_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-339-5p | chr2 | 165874337 | 165874343 | 7mer-m8 | 165874336 | 165874358 | 148 | -13.97 |
| ADediting_823113 | chr2_165874338_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-5699-3p | chr2 | 165874338 | 165874344 | 7mer-m8 | 165874337 | 165874358 | 150 | -16.38 |
| ADediting_823113 | chr2_165874338_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6775-3p | chr2 | 165874335 | 165874341 | 7mer-m8 | 165874334 | 165874354 | 152 | -22.17 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_823099 | chr2_165874084_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6514-3p | chr2 | 165874084 | 165874090 | 7mer-m8 | 165874083 | 165874103 | 155 | -17.54 |
| ADediting_823099 | chr2_165874084_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6847-3p | chr2 | 165874079 | 165874085 | 7mer-m8 | 165874078 | 165874100 | 153 | -22.19 |
| ADediting_823101 | chr2_165874103_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-887-5p | chr2 | 165874102 | 165874109 | 8mer-1a | 165874102 | 165874123 | 148 | -16.01 |
| ADediting_823102 | chr2_165874157_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-4794 | chr2 | 165874152 | 165874158 | 7mer-m8 | 165874151 | 165874173 | 145 | -20.59 |
| ADediting_823102 | chr2_165874157_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-664a-5p | chr2 | 165874152 | 165874158 | 7mer-m8 | 165874151 | 165874178 | 143 | -16.58 |
| ADediting_823104 | chr2_165874179_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-3675-3p | chr2 | 165874174 | 165874180 | 7mer-m8 | 165874173 | 165874194 | 145 | -12.58 |
| ADediting_823108 | chr2_165874222_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-532-5p | chr2 | 165874217 | 165874223 | 7mer-m8 | 165874216 | 165874237 | 153 | -18.63 |
| ADediting_823109 | chr2_165874234_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-5690 | chr2 | 165874230 | 165874236 | 7mer-m8 | 165874229 | 165874249 | 145 | -16.75 |
| ADediting_823110 | chr2_165874246_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-4478 | chr2 | 165874242 | 165874248 | 7mer-m8 | 165874241 | 165874258 | 146 | -24.68 |
| ADediting_823110 | chr2_165874246_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-485-5p | chr2 | 165874241 | 165874247 | 7mer-m8 | 165874240 | 165874261 | 153 | -19.99 |
| ADediting_823111 | chr2_165874283_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-377-5p | chr2 | 165874279 | 165874285 | 7mer-m8 | 165874278 | 165874299 | 155 | -17.55 |
| ADediting_823111 | chr2_165874283_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6086 | chr2 | 165874279 | 165874285 | 7mer-m8 | 165874278 | 165874297 | 148 | -21.93 |
| ADediting_823111 | chr2_165874283_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6516-5p | chr2 | 165874283 | 165874289 | 7mer-m8 | 165874282 | 165874307 | 148 | -17.08 |
| ADediting_823112 | chr2_165874302_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-1227-3p | chr2 | 165874301 | 165874307 | 7mer-m8 | 165874300 | 165874319 | 148 | -22.88 |
| ADediting_823113 | chr2_165874338_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6888-3p | chr2 | 165874338 | 165874344 | 7mer-m8 | 165874337 | 165874357 | 140 | -9.4 |
| ADediting_823113 | chr2_165874338_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-760 | chr2 | 165874335 | 165874341 | 7mer-m8 | 165874334 | 165874351 | 147 | -14.43 |
| ADediting_823114 | chr2_165874340_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-511-5p | chr2 | 165874340 | 165874346 | 7mer-m8 | 165874339 | 165874359 | 140 | -6.6 |
| ADediting_823114 | chr2_165874340_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-6888-3p | chr2 | 165874338 | 165874344 | 7mer-m8 | 165874337 | 165874357 | 140 | -9.4 |
| ADediting_823114 | chr2_165874340_- | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-760 | chr2 | 165874335 | 165874341 | 7mer-m8 | 165874334 | 165874351 | 147 | -14.43 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-4477b | chr2 | 165873400 | 165873406 | 7mer-m8 | 165873399 | 165873417 | 156 | -18.01 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-381-3p | chr2 | 165874444 | 165874450 | 7mer-m8 | 165874443 | 165874464 | 145 | -13.13 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-5688 | chr2 | 165874374 | 165874380 | 7mer-1a | 165874374 | 165874396 | 143 | -12.5 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000123607.15 | ENST00000243344.8 | TTC21B-201 | hsa-miR-1273h-3p | chr2 | 165873652 | 165873658 | 7mer-m8 | 165873651 | 165873672 | 152 | -22.87 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TTC21B |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000243344.8 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_823099 | ENST00000243344.8 | chr2_165874084_- | 4693 | -1417.80 | -1417.60 | -1434.60 |
| ADediting_823100 | ENST00000243344.8 | chr2_165874102_- | 4675 | -1421.90 | -1417.60 | -1434.60 |
| ADediting_823101 | ENST00000243344.8 | chr2_165874103_- | 4674 | -1421.60 | -1417.60 | -1434.60 |
| ADediting_823102 | ENST00000243344.8 | chr2_165874157_- | 4620 | -1419.70 | -1417.60 | -1434.60 |
| ADediting_823103 | ENST00000243344.8 | chr2_165874165_- | 4612 | -1420.50 | -1417.60 | -1434.60 |
| ADediting_823104 | ENST00000243344.8 | chr2_165874179_- | 4598 | -1419.80 | -1417.60 | -1434.60 |
| ADediting_823105 | ENST00000243344.8 | chr2_165874182_- | 4595 | -1422.20 | -1417.60 | -1434.60 |
| ADediting_823106 | ENST00000243344.8 | chr2_165874188_- | 4589 | -1419.10 | -1417.60 | -1434.60 |
| ADediting_823107 | ENST00000243344.8 | chr2_165874198_- | 4579 | -1417.30 | -1417.60 | -1434.60 |
| ADediting_823108 | ENST00000243344.8 | chr2_165874222_- | 4555 | -1418.40 | -1417.60 | -1434.60 |
| ADediting_823109 | ENST00000243344.8 | chr2_165874234_- | 4543 | -1420.90 | -1417.60 | -1434.60 |
| ADediting_823110 | ENST00000243344.8 | chr2_165874246_- | 4531 | -1420.40 | -1417.60 | -1434.60 |
| ADediting_823111 | ENST00000243344.8 | chr2_165874283_- | 4494 | -1420.50 | -1417.60 | -1434.60 |
| ADediting_823112 | ENST00000243344.8 | chr2_165874302_- | 4475 | -1418.40 | -1417.60 | -1434.60 |
| ADediting_823113 | ENST00000243344.8 | chr2_165874338_- | 4439 | -1420.60 | -1417.60 | -1434.60 |
| ADediting_823114 | ENST00000243344.8 | chr2_165874340_- | 4437 | -1417.30 | -1417.60 | -1434.60 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TTC21B |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_823072 | chr2_165865316_- | 0.342643013339494 | 0.0540760849567399 | 0.435494913969456 | -0.0444486520510282 | 5.55322825374036e-11 | 0.36113490836815 |
| CER | ADediting_823102 | chr2_165874157_- | 4.3902681594503e-06 | 0.364971957792282 | 5.10539467821152e-10 | 0.480030012246854 | 0.00662972142731696 | 0.220774849931591 |
| CER | ADediting_823104 | chr2_165874179_- | 7.00532306049794e-05 | 0.318802091219547 | 7.04699677571874e-10 | 0.476592874203012 | 0.0809834648559562 | 0.142942494417414 |
| CER | ADediting_823105 | chr2_165874182_- | 0.000127214957296612 | 0.307808385366731 | 4.11681693643114e-08 | 0.429589509965577 | 0.015831636940647 | 0.196718846299113 |
| CER | ADediting_823111 | chr2_165874283_- | 0.000128038448404001 | 0.307687110487696 | 2.00782631519496e-05 | 0.340540486165939 | 0.0186467289413062 | 0.191898961444836 |
| CER | ADediting_823112 | chr2_165874302_- | 4.70219736342728e-05 | 0.325917067130621 | 4.75791404534394e-08 | 0.427778442088016 | 0.000592348056827085 | 0.277273794770357 |
| DLPFC | ADediting_823116 | chr2_165878961_- | 0.118717149906936 | 0.0887959105401807 | 0.335100807916425 | 0.0549258540455068 | 2.38352475788888e-08 | 0.310401520914672 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.73519718173233e-46 | 0.69747458979596 | 2.82073901332723e-40 | 0.660826401687906 | 2.18285446746314e-17 | 0.456810157553617 |
| AC | 7.06454926550124e-95 | 0.906550063855988 | 1.21688019915084e-66 | 0.836189916612347 | 4.49667473936134e-13 | 0.436856395376512 |
| PCC | 7.2022931792353e-45 | 0.805763253550026 | 2.08208675445231e-46 | 0.813712960869848 | 1.39406869360094e-05 | 0.308692326092114 |
| CER | 5.99232226670742e-35 | 0.802081305249856 | 1.91543275807219e-20 | 0.66429209239635 | 0.0187403618681028 | 0.191749793252268 |
| TCX | 3.67698454021877e-40 | 0.834608703868896 | 1.80350982087874e-21 | 0.677277079512548 | 0.010474734387819 | 0.20844547722851 |
| FP | 9.37708557433824e-25 | 0.672189822738172 | 1.23837937667031e-32 | 0.743948418136417 | 0.180031876794972 | 0.100940787514964 |
| IFG | 4.19940067172997e-06 | 0.780400750652984 | 0.000170780222877094 | 0.682514491207731 | 0.00523827128727586 | 0.540919579485045 |
| PG | 2.08526668891323e-51 | 0.842888972208939 | 2.39015407389442e-38 | 0.773883277291852 | 0.473037019966113 | -0.0529329916260848 |
| STG | 3.80722985347566e-24 | 0.846352208543177 | 1.87594281854289e-22 | 0.829559730939945 | 0.330686328872639 | 0.107436020283424 |
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Relation with AD stages for TTC21B |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_823102 | chr2_165874157_- | 5.89619118398594e-05 | 0.376581650484129 |
| CER | ADediting_823104 | chr2_165874179_- | 0.0010662368534377 | 0.31067562223102 |
| CER | ADediting_823105 | chr2_165874182_- | 0.000194993896776992 | 0.351082458835318 |
| CER | ADediting_823112 | chr2_165874302_- | 0.000844703798327612 | 0.316554203450793 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.68963829942118e-06 | 0.428638834412514 |
| TCX | 8.99886241870781e-05 | 0.371091855383339 |
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RelatedDrugs for TTC21B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTC21B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TTC21B | C3151186 | NEPHRONOPHTHISIS 12 | 2 | CTD_human;UNIPROT |
| TTC21B | C3279203 | JOUBERT SYNDROME 11 | 2 | CTD_human;UNIPROT |
| TTC21B | C0013146 | Drug abuse | 1 | CTD_human |
| TTC21B | C0013170 | Drug habituation | 1 | CTD_human |
| TTC21B | C0013222 | Drug Use Disorders | 1 | CTD_human |
| TTC21B | C0022658 | Kidney Diseases | 1 | CTD_human |
| TTC21B | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| TTC21B | C0038580 | Substance Dependence | 1 | CTD_human |
| TTC21B | C0038586 | Substance Use Disorders | 1 | CTD_human |
| TTC21B | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| TTC21B | C0265275 | Jeune thoracic dystrophy | 1 | CTD_human;ORPHANET |
| TTC21B | C0740858 | Substance abuse problem | 1 | CTD_human |
| TTC21B | C1510472 | Drug Dependence | 1 | CTD_human |
| TTC21B | C3151185 | SHORT-RIB THORACIC DYSPLASIA 4 WITH OR WITHOUT POLYDACTYLY | 1 | UNIPROT |
| TTC21B | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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