|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for ZFYVE21 |
 Gene summary |
| Gene information | Gene symbol | ZFYVE21 | Gene ID | 79038 |
| Gene name | zinc finger FYVE-type containing 21 | |
| Synonyms | HCVP7TP1|ZF21 | |
| Cytomap | 14q32.33 | |
| Type of gene | protein-coding | |
| Description | zinc finger FYVE domain-containing protein 21FYVE domain containing 21HCV p7-transactivated protein 1zinc finger, FYVE domain containing 21 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9BQ24, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for ZFYVE21 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_417012(103718452, +), ADediting_417013(103719157, +), ADediting_417014(103719158, +), ADediting_417015(103719313, +), ADediting_417016(103719349, +), ADediting_417017(103719376, +), ADediting_417018(103719384, +), ADediting_417019(103719397, +), ADediting_417020(103719404, +), ADediting_417021(103720846, +), ADediting_417022(103720922, +), ADediting_417023(103720923, +), ADediting_417024(103720952, +), ADediting_417025(103722411, +), ADediting_417026(103722481, +), ADediting_417027(103722484, +), ADediting_417028(103722494, +), ADediting_417029(103722556, +), ADediting_417030(103722564, +), ADediting_417031(103722565, +), ADediting_417032(103722636, +), ADediting_417033(103722698, +), ADediting_417034(103722704, +), ADediting_417035(103722715, +), ADediting_417036(103722721, +), ADediting_417037(103722839, +), ADediting_417038(103722885, +), ADediting_417039(103722902, +), ADediting_417040(103722924, +), ADediting_1536159(103719163, +), ADediting_1536160(103722378, +), ADediting_1536161(103722441, +), ADediting_1536162(103727143, +), |
Top |
RNA editing positional annotations for ZFYVE21 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_417012 | chr14_103718452_+ | intronic |
| ADediting_417013 | chr14_103719157_+ | intronic |
| ADediting_417014 | chr14_103719158_+ | intronic |
| ADediting_417015 | chr14_103719313_+ | intronic |
| ADediting_417016 | chr14_103719349_+ | intronic |
| ADediting_417017 | chr14_103719376_+ | intronic |
| ADediting_417018 | chr14_103719384_+ | intronic |
| ADediting_417019 | chr14_103719397_+ | intronic |
| ADediting_417020 | chr14_103719404_+ | intronic |
| ADediting_417021 | chr14_103720846_+ | intronic |
| ADediting_417022 | chr14_103720922_+ | intronic |
| ADediting_417023 | chr14_103720923_+ | intronic |
| ADediting_417024 | chr14_103720952_+ | intronic |
| ADediting_417025 | chr14_103722411_+ | intronic |
| ADediting_417026 | chr14_103722481_+ | intronic |
| ADediting_417027 | chr14_103722484_+ | intronic |
| ADediting_417028 | chr14_103722494_+ | intronic |
| ADediting_417029 | chr14_103722556_+ | intronic |
| ADediting_417030 | chr14_103722564_+ | intronic |
| ADediting_417031 | chr14_103722565_+ | intronic |
| ADediting_417032 | chr14_103722636_+ | intronic |
| ADediting_417033 | chr14_103722698_+ | intronic |
| ADediting_417034 | chr14_103722704_+ | intronic |
| ADediting_417035 | chr14_103722715_+ | intronic |
| ADediting_417036 | chr14_103722721_+ | intronic |
| ADediting_417037 | chr14_103722839_+ | intronic |
| ADediting_417038 | chr14_103722885_+ | intronic |
| ADediting_417039 | chr14_103722902_+ | intronic |
| ADediting_417040 | chr14_103722924_+ | intronic |
| ADediting_1536159 | chr14_103719163_+ | intronic |
| ADediting_1536160 | chr14_103722378_+ | intronic |
| ADediting_1536161 | chr14_103722441_+ | intronic |
| ADediting_1536162 | chr14_103727143_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_417013 | chr14_103719157_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417014 | chr14_103719158_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417015 | chr14_103719313_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417016 | chr14_103719349_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417017 | chr14_103719376_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417018 | chr14_103719384_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417019 | chr14_103719397_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417020 | chr14_103719404_+ | SINE | Alu | Name=AluSz6 |
| ADediting_417021 | chr14_103720846_+ | SINE | Alu | Name=AluSx1 |
| ADediting_417022 | chr14_103720922_+ | SINE | Alu | Name=AluSx1 |
| ADediting_417023 | chr14_103720923_+ | SINE | Alu | Name=AluSx1 |
| ADediting_417024 | chr14_103720952_+ | SINE | Alu | Name=AluSx1 |
| ADediting_417025 | chr14_103722411_+ | SINE | Alu | Name=AluJr |
| ADediting_417026 | chr14_103722481_+ | SINE | Alu | Name=AluJr |
| ADediting_417027 | chr14_103722484_+ | SINE | Alu | Name=AluJr |
| ADediting_417028 | chr14_103722494_+ | SINE | Alu | Name=AluJr |
| ADediting_417029 | chr14_103722556_+ | SINE | Alu | Name=AluY |
| ADediting_417030 | chr14_103722564_+ | SINE | Alu | Name=AluY |
| ADediting_417031 | chr14_103722565_+ | SINE | Alu | Name=AluY |
| ADediting_417032 | chr14_103722636_+ | SINE | Alu | Name=AluY |
| ADediting_417033 | chr14_103722698_+ | SINE | Alu | Name=AluY |
| ADediting_417034 | chr14_103722704_+ | SINE | Alu | Name=AluY |
| ADediting_417035 | chr14_103722715_+ | SINE | Alu | Name=AluY |
| ADediting_417036 | chr14_103722721_+ | SINE | Alu | Name=AluY |
| ADediting_417037 | chr14_103722839_+ | SINE | Alu | Name=AluJr |
| ADediting_417038 | chr14_103722885_+ | SINE | Alu | Name=AluJr |
| ADediting_417039 | chr14_103722902_+ | SINE | Alu | Name=AluJr |
| ADediting_417040 | chr14_103722924_+ | SINE | Alu | Name=AluJr |
| ADediting_1536159 | chr14_103719163_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1536160 | chr14_103722378_+ | SINE | Alu | Name=AluJr |
| ADediting_1536161 | chr14_103722441_+ | SINE | Alu | Name=AluJr |
| ADediting_1536162 | chr14_103727143_+ | SINE | Alu | Name=AluSq2 |
Top |
RNA A-to-I editing events in the alternative splicing sites for ZFYVE21 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZFYVE21 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
 | |
 | |
 | |
 | |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for ZFYVE21 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for ZFYVE21 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_527135 | chr16_24203190_+ | ENSG00000100711.13 | ENST00000216602.10 | ZFYVE21-201 | hsa-miR-1273h-3p | chr14 | 103733416 | 103733422 | 7mer-m8 | 103733402 | 103733423 | 152 | -21.59 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000100711.13 | ENST00000311141.6 | ZFYVE21-202 | hsa-miR-1273h-3p | chr14 | 103733416 | 103733422 | 7mer-m8 | 103733402 | 103733423 | 152 | -21.59 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for ZFYVE21 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for ZFYVE21 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1536160 | chr14_103722378_+ | 0.0394484009426052 | 0.168361858954471 | 3.23059870869898e-05 | 0.332458802339795 | 0.0618082046349156 | 0.152875783095986 |
| DLPFC | ADediting_417013 | chr14_103719157_+ | 0.0692775372536736 | 0.103317362888736 | 0.579938462667957 | 0.0315548901523179 | 6.06919493983949e-08 | 0.301672526650702 |
| CER | ADediting_417016 | chr14_103719349_+ | 0.000488540355633776 | 0.281291485549287 | 6.69818566775565e-10 | 0.477136775708648 | 0.0177720045047331 | 0.193324765619581 |
| CER | ADediting_417018 | chr14_103719384_+ | 0.000228422959449296 | 0.296586294721851 | 6.89528019071467e-09 | 0.451117969620297 | 0.00106607816176104 | 0.264630857997363 |
| CER | ADediting_417019 | chr14_103719397_+ | 0.0159050280245816 | 0.196584051639541 | 9.9732468378163e-07 | 0.387004379395633 | 0.00967796832541184 | 0.210624909217451 |
| CER | ADediting_417022 | chr14_103720922_+ | 0.000507733715466168 | 0.28049273560835 | 6.42226096428449e-08 | 0.423990742301501 | 0.0304271170045771 | 0.176813751977207 |
| CER | ADediting_417023 | chr14_103720923_+ | 0.0232365857539534 | 0.185248509830583 | 4.59830344523413e-05 | 0.326310644042513 | 0.0576429917683112 | 0.155361104902693 |
| CER | ADediting_417025 | chr14_103722411_+ | 0.000131606799953904 | 0.307169870594612 | 2.44343186056804e-06 | 0.37387714764207 | 0.107247668873071 | 0.132040250671671 |
| DLPFC | ADediting_417028 | chr14_103722494_+ | 0.0563466087002389 | 0.108504853835467 | 0.850067938068484 | 0.0107795162446556 | 9.6653840832736e-09 | 0.318570512431522 |
| CER | ADediting_417028 | chr14_103722494_+ | 0.00155768687159469 | 0.256135809424537 | 4.45274940565419e-06 | 0.364753893420417 | 1.02368704963652e-05 | 0.351616895002759 |
| DLPFC | ADediting_417030 | chr14_103722564_+ | 0.000599009457297232 | 0.193858796670572 | 0.416747118298074 | 0.0462851635014285 | 9.78035070134823e-12 | 0.374139375541276 |
| CER | ADediting_417030 | chr14_103722564_+ | 0.00122717836430504 | 0.261510625646177 | 8.72104659696245e-07 | 0.388921729581023 | 0.0494643184515344 | 0.160706467091633 |
| DLPFC | ADediting_417031 | chr14_103722565_+ | 0.130770072659562 | 0.086011479919486 | 0.966284271983453 | 0.00241045101374033 | 1.8006835149004e-11 | 0.3696347611808 |
| CER | ADediting_417031 | chr14_103722565_+ | 7.19195540084791e-05 | 0.318326507306997 | 1.31850579471887e-07 | 0.414713667682373 | 0.185428966822203 | 0.108711044996177 |
| CER | ADediting_417033 | chr14_103722698_+ | 0.00016056526797563 | 0.30339871936383 | 4.01454631865767e-06 | 0.366348833868587 | 0.0813758691587854 | 0.142760085671739 |
| DLPFC | ADediting_417038 | chr14_103722885_+ | 0.0948194328725905 | 0.0950473855375672 | 0.608652179251987 | -0.0291912787018159 | 4.15282106140576e-10 | 0.345293337521376 |
| CER | ADediting_417039 | chr14_103722902_+ | 0.00167531157082788 | 0.254472570454826 | 1.86552819645156e-06 | 0.377890933935822 | 0.220678742759033 | 0.100586024975854 |
| CER | ADediting_417040 | chr14_103722924_+ | 0.00166329191964844 | 0.254637564115548 | 7.08167846711568e-05 | 0.318606102060894 | 0.669773333868509 | -0.0351031598045184 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.71626923139968e-23 | 0.52432351626703 | 6.80468151359927e-22 | 0.509630891327993 | 5.2901427233428e-29 | 0.577792489034816 |
| AC | 1.07826043302138e-31 | 0.6523585246937 | 6.59954809712496e-17 | 0.495679242821463 | 8.3483822200752e-33 | 0.661242715369954 |
| PCC | 3.59534176129005e-10 | 0.433902941574096 | 6.5477902677503e-08 | 0.378779022272835 | 9.06582200576236e-08 | 0.374973584029311 |
| CER | 4.24946163302887e-07 | 0.398994998927085 | 4.59675077570173e-08 | 0.42821061628973 | 2.73065760104382e-08 | 0.434669823465623 |
| TCX | 5.80403715304517e-05 | 0.322181736368732 | 0.121200770274599 | 0.127086317657697 | 0.000334220834331562 | 0.289036398304674 |
| FP | 4.04809097271662e-16 | 0.560581618964556 | 0.000143274047388878 | 0.281213530570883 | 5.6397788104729e-10 | 0.443513185649004 |
| IFG | 3.99113417998826e-07 | 0.824635682898365 | 1.94197037122877e-05 | 0.744929874707847 | 0.209034639450433 | 0.260211491621746 |
| PG | 1.80133281704313e-29 | 0.706814357620303 | 6.77883800320141e-14 | 0.513340003074033 | 0.00274633329367692 | 0.218403825313671 |
| STG | 1.79195748041982e-12 | 0.675600734682554 | 7.97606724700347e-05 | 0.416921177204006 | 0.0285646691070359 | 0.238995502114283 |
Top |
Relation with AD stages for ZFYVE21 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_417016 | chr14_103719349_+ | 5.25946435472949e-05 | 0.378910147980335 |
| CER | ADediting_417018 | chr14_103719384_+ | 2.80458234554538e-05 | 0.391416484056359 |
| CER | ADediting_417022 | chr14_103720922_+ | 0.00058728922796158 | 0.3254978286228 |
| CER | ADediting_417028 | chr14_103722494_+ | 0.000225870330362841 | 0.347795416926357 |
| CER | ADediting_417031 | chr14_103722565_+ | 0.000138014157728123 | 0.358672808809281 |
| CER | ADediting_417039 | chr14_103722902_+ | 0.00129862337157379 | 0.305603930929063 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.23721904296346e-05 | 0.38860731499508 |
| TCX | 2.9687218937717e-05 | 0.393752520398047 |
Top |
RelatedDrugs for ZFYVE21 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZFYVE21 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|