ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for MIS12

Gene summary

Gene information	Gene symbol	MIS12
	Gene ID	79003
	Gene name	MIS12 kinetochore complex component
	Synonyms	2510025F08Rik\|KNTC2AP\|MTW1\|hMis12
	Cytomap	17p13.2
	Type of gene	protein-coding
	Description	protein MIS12 homologMIS12 homologMIS12, MIND kinetochore complex component, homologhomolog of yeast Mis12
	Modification date	20200313
	UniProtAcc	Q9H081,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MIS12	GO:0051382	kinetochore assembly	16585270

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RNA A-to-I events for MIS12

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_639922(5487143, +), ADediting_639923(5487144, +), ADediting_639924(5487153, +), ADediting_639925(5487171, +), ADediting_639926(5487179, +), ADediting_639927(5487185, +), ADediting_639928(5487196, +), ADediting_639929(5487221, +), ADediting_639930(5487266, +), ADediting_639931(5487269, +), ADediting_639932(5487272, +), ADediting_639933(5487289, +), ADediting_639934(5487297, +), ADediting_639935(5487309, +), ADediting_639936(5487325, +), ADediting_639937(5487377, +), ADediting_639938(5487396, +), ADediting_639939(5487593, +), ADediting_639940(5487595, +), ADediting_639941(5487596, +), ADediting_639942(5487606, +), ADediting_639943(5487611, +), ADediting_639944(5487612, +), ADediting_639945(5487632, +), ADediting_639946(5487649, +), ADediting_639947(5487661, +), ADediting_639948(5487674, +), ADediting_639949(5487677, +), ADediting_639950(5487698, +), ADediting_639951(5489889, +), ADediting_639952(5489944, +), ADediting_639953(5489950, +), ADediting_639954(5489969, +), ADediting_639955(5489970, +), ADediting_639956(5489987, +), ADediting_639957(5489995, +), ADediting_639958(5490003, +), ADediting_639959(5490009, +), ADediting_639960(5490049, +), ADediting_1547599(5487149, +), ADediting_1547600(5487184, +), ADediting_1547601(5487189, +), ADediting_1547602(5487286, +), ADediting_1547603(5487332, +),

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RNA editing positional annotations for MIS12 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_639922	chr17_5487143_+	intronic
ADediting_639923	chr17_5487144_+	intronic
ADediting_639924	chr17_5487153_+	intronic
ADediting_639925	chr17_5487171_+	intronic
ADediting_639926	chr17_5487179_+	intronic
ADediting_639927	chr17_5487185_+	intronic
ADediting_639928	chr17_5487196_+	intronic
ADediting_639929	chr17_5487221_+	intronic
ADediting_639930	chr17_5487266_+	intronic
ADediting_639931	chr17_5487269_+	intronic
ADediting_639932	chr17_5487272_+	intronic
ADediting_639933	chr17_5487289_+	intronic
ADediting_639934	chr17_5487297_+	intronic
ADediting_639935	chr17_5487309_+	intronic
ADediting_639936	chr17_5487325_+	intronic
ADediting_639937	chr17_5487377_+	intronic
ADediting_639938	chr17_5487396_+	intronic
ADediting_639939	chr17_5487593_+	UTR5
ADediting_639940	chr17_5487595_+	UTR5
ADediting_639941	chr17_5487596_+	UTR5
ADediting_639942	chr17_5487606_+	UTR5
ADediting_639943	chr17_5487611_+	UTR5
ADediting_639944	chr17_5487612_+	UTR5
ADediting_639945	chr17_5487632_+	UTR5
ADediting_639946	chr17_5487649_+	UTR5
ADediting_639947	chr17_5487661_+	UTR5
ADediting_639948	chr17_5487674_+	UTR5
ADediting_639949	chr17_5487677_+	UTR5
ADediting_639950	chr17_5487698_+	intronic
ADediting_639951	chr17_5489889_+	UTR3
ADediting_639952	chr17_5489944_+	UTR3
ADediting_639953	chr17_5489950_+	UTR3
ADediting_639954	chr17_5489969_+	UTR3
ADediting_639955	chr17_5489970_+	UTR3
ADediting_639956	chr17_5489987_+	UTR3
ADediting_639957	chr17_5489995_+	UTR3
ADediting_639958	chr17_5490003_+	UTR3
ADediting_639959	chr17_5490009_+	UTR3
ADediting_639960	chr17_5490049_+	UTR3
ADediting_1547599	chr17_5487149_+	intronic
ADediting_1547600	chr17_5487184_+	intronic
ADediting_1547601	chr17_5487189_+	intronic
ADediting_1547602	chr17_5487286_+	intronic
ADediting_1547603	chr17_5487332_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_639922	chr17_5487143_+	SINE	Alu	Name=AluJb
ADediting_639923	chr17_5487144_+	SINE	Alu	Name=AluJb
ADediting_639924	chr17_5487153_+	SINE	Alu	Name=AluJb
ADediting_639925	chr17_5487171_+	SINE	Alu	Name=AluJb
ADediting_639926	chr17_5487179_+	SINE	Alu	Name=AluJb
ADediting_639927	chr17_5487185_+	SINE	Alu	Name=AluJb
ADediting_639928	chr17_5487196_+	SINE	Alu	Name=AluJb
ADediting_639929	chr17_5487221_+	SINE	Alu	Name=AluJb
ADediting_639930	chr17_5487266_+	SINE	Alu	Name=AluJb
ADediting_639931	chr17_5487269_+	SINE	Alu	Name=AluJb
ADediting_639932	chr17_5487272_+	SINE	Alu	Name=AluJb
ADediting_639933	chr17_5487289_+	SINE	Alu	Name=AluJb
ADediting_639934	chr17_5487297_+	SINE	Alu	Name=AluJb
ADediting_639935	chr17_5487309_+	SINE	Alu	Name=AluJb
ADediting_639936	chr17_5487325_+	SINE	Alu	Name=AluJb
ADediting_639937	chr17_5487377_+	SINE	Alu	Name=AluJb
ADediting_639938	chr17_5487396_+	SINE	Alu	Name=AluJb
ADediting_639939	chr17_5487593_+	SINE	Alu	Name=AluSx1
ADediting_639940	chr17_5487595_+	SINE	Alu	Name=AluSx1
ADediting_639941	chr17_5487596_+	SINE	Alu	Name=AluSx1
ADediting_639942	chr17_5487606_+	SINE	Alu	Name=AluSx1
ADediting_639943	chr17_5487611_+	SINE	Alu	Name=AluSx1
ADediting_639944	chr17_5487612_+	SINE	Alu	Name=AluSx1
ADediting_639945	chr17_5487632_+	SINE	Alu	Name=AluSx1
ADediting_639946	chr17_5487649_+	SINE	Alu	Name=AluSx1
ADediting_639947	chr17_5487661_+	SINE	Alu	Name=AluSx1
ADediting_639948	chr17_5487674_+	SINE	Alu	Name=AluSx1
ADediting_639949	chr17_5487677_+	SINE	Alu	Name=AluSx1
ADediting_639950	chr17_5487698_+	SINE	Alu	Name=AluSx1
ADediting_639951	chr17_5489889_+	SINE	Alu	Name=AluJr4
ADediting_639952	chr17_5489944_+	SINE	Alu	Name=AluJr4
ADediting_639953	chr17_5489950_+	SINE	Alu	Name=AluJr4
ADediting_639954	chr17_5489969_+	SINE	Alu	Name=AluJr4
ADediting_639955	chr17_5489970_+	SINE	Alu	Name=AluJr4
ADediting_639956	chr17_5489987_+	SINE	Alu	Name=AluJr4
ADediting_639957	chr17_5489995_+	SINE	Alu	Name=AluJr4
ADediting_639958	chr17_5490003_+	SINE	Alu	Name=AluJr4
ADediting_639959	chr17_5490009_+	SINE	Alu	Name=AluJr4
ADediting_639960	chr17_5490049_+	SINE	Alu	Name=AluJr4
ADediting_1547599	chr17_5487149_+	SINE	Alu	Name=AluJb
ADediting_1547600	chr17_5487184_+	SINE	Alu	Name=AluJb
ADediting_1547601	chr17_5487189_+	SINE	Alu	Name=AluJb
ADediting_1547602	chr17_5487286_+	SINE	Alu	Name=AluJb
ADediting_1547603	chr17_5487332_+	SINE	Alu	Name=AluJb

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RNA A-to-I editing events in the alternative splicing sites for MIS12

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MIS12

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for MIS12

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MIS12

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-10a-5p	chr17	5489885	5489891	7mer-m8	5489872	5489892	142	-12.59
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-10b-5p	chr17	5489885	5489891	7mer-m8	5489867	5489892	147	-12.87
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-339-5p	chr17	5489884	5489890	7mer-m8	5489870	5489891	150	-19.4
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-4421	chr17	5489883	5489889	7mer-m8	5489870	5489890	152	-14.2
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-4725-5p	chr17	5489886	5489892	7mer-m8	5489873	5489893	140	-14.16
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-504-5p	chr17	5489886	5489892	7mer-m8	5489874	5489893	147	-16.35
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-5699-3p	chr17	5489883	5489889	7mer-m8	5489869	5489890	141	-16.39
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-10a-5p	chr17	5489885	5489891	7mer-m8	5489872	5489892	142	-12.59
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-10b-5p	chr17	5489885	5489891	7mer-m8	5489867	5489892	147	-12.87
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-339-5p	chr17	5489884	5489890	7mer-m8	5489870	5489891	150	-19.4
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-4421	chr17	5489883	5489889	7mer-m8	5489870	5489890	152	-14.2
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-4725-5p	chr17	5489886	5489892	7mer-m8	5489873	5489893	140	-14.16
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-504-5p	chr17	5489886	5489892	7mer-m8	5489874	5489893	147	-16.35
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-5699-3p	chr17	5489883	5489889	7mer-m8	5489869	5489890	141	-16.39
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-10a-5p	chr17	5489885	5489891	7mer-m8	5489872	5489892	142	-12.59
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-10b-5p	chr17	5489885	5489891	7mer-m8	5489867	5489892	147	-12.87
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-339-5p	chr17	5489884	5489890	7mer-m8	5489870	5489891	150	-19.4
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-4421	chr17	5489883	5489889	7mer-m8	5489870	5489890	152	-14.2
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-4725-5p	chr17	5489886	5489892	7mer-m8	5489873	5489893	140	-14.16
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-504-5p	chr17	5489886	5489892	7mer-m8	5489874	5489893	147	-16.35
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-5699-3p	chr17	5489883	5489889	7mer-m8	5489869	5489890	141	-16.39
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-17-3p	chr17	5489943	5489949	7mer-m8	5489928	5489950	157	-20.02
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-485-5p	chr17	5489947	5489953	7mer-m8	5489934	5489954	153	-19.66
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6884-5p	chr17	5489947	5489953	7mer-m8	5489932	5489954	146	-21.96
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-17-3p	chr17	5489943	5489949	7mer-m8	5489928	5489950	157	-20.02
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-485-5p	chr17	5489947	5489953	7mer-m8	5489934	5489954	153	-19.66
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6884-5p	chr17	5489947	5489953	7mer-m8	5489932	5489954	146	-21.96
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-17-3p	chr17	5489943	5489949	7mer-m8	5489928	5489950	157	-20.02
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-485-5p	chr17	5489947	5489953	7mer-m8	5489934	5489954	153	-19.66
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6884-5p	chr17	5489947	5489953	7mer-m8	5489932	5489954	146	-21.96
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-3622a-3p	chr17	5489966	5489973	8mer-1a	5489952	5489973	148	-19.86
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-3622b-3p	chr17	5489966	5489973	8mer-1a	5489953	5489973	156	-23.59
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6751-3p	chr17	5489963	5489969	7mer-m8	5489950	5489970	141	-15.51
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-3622a-3p	chr17	5489966	5489973	8mer-1a	5489952	5489973	148	-19.86
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-3622b-3p	chr17	5489966	5489973	8mer-1a	5489953	5489973	156	-23.59
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6751-3p	chr17	5489963	5489969	7mer-m8	5489950	5489970	141	-15.51
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-3622a-3p	chr17	5489966	5489973	8mer-1a	5489952	5489973	148	-19.86
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-3622b-3p	chr17	5489966	5489973	8mer-1a	5489953	5489973	156	-23.59
ADediting_639955	chr17_5489970_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6751-3p	chr17	5489963	5489969	7mer-m8	5489950	5489970	141	-15.51
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6089	chr17	5489985	5489991	7mer-m8	5489970	5489992	168	-39.94
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6089	chr17	5489985	5489991	7mer-m8	5489970	5489992	168	-39.94
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6089	chr17	5489985	5489991	7mer-m8	5489970	5489992	168	-39.94
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6771-5p	chr17	5489989	5489995	7mer-m8	5489977	5489996	160	-34.33
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6771-5p	chr17	5489989	5489995	7mer-m8	5489977	5489996	160	-34.33
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6771-5p	chr17	5489989	5489995	7mer-m8	5489977	5489996	160	-34.33
ADediting_639958	chr17_5490003_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-5690	chr17	5489996	5490002	7mer-m8	5489983	5490003	145	-16.74
ADediting_639958	chr17_5490003_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-7977	chr17	5489999	5490005	7mer-m8	5489989	5490006	142	-12.24
ADediting_639958	chr17_5490003_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-5690	chr17	5489996	5490002	7mer-m8	5489983	5490003	145	-16.74
ADediting_639958	chr17_5490003_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-7977	chr17	5489999	5490005	7mer-m8	5489989	5490006	142	-12.24
ADediting_639958	chr17_5490003_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-5690	chr17	5489996	5490002	7mer-m8	5489983	5490003	145	-16.74
ADediting_639958	chr17_5490003_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-7977	chr17	5489999	5490005	7mer-m8	5489989	5490006	142	-12.24
ADediting_639960	chr17_5490049_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-593-3p	chr17	5490044	5490050	7mer-m8	5490033	5490051	146	-17.64
ADediting_639960	chr17_5490049_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-593-3p	chr17	5490044	5490050	7mer-m8	5490033	5490051	146	-17.64
ADediting_639960	chr17_5490049_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-593-3p	chr17	5490044	5490050	7mer-m8	5490033	5490051	146	-17.64

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-659-5p	chr17	5489887	5489893	7mer-m8	5489871	5489894	154	-14.61
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-659-5p	chr17	5489887	5489893	7mer-m8	5489871	5489894	154	-14.61
ADediting_639951	chr17_5489889_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-659-5p	chr17	5489887	5489893	7mer-m8	5489871	5489894	154	-14.61
ADediting_639952	chr17_5489944_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6807-5p	chr17	5489937	5489943	7mer-m8	5489925	5489944	145	-17.12
ADediting_639952	chr17_5489944_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6807-5p	chr17	5489937	5489943	7mer-m8	5489925	5489944	145	-17.12
ADediting_639952	chr17_5489944_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6807-5p	chr17	5489937	5489943	7mer-m8	5489925	5489944	145	-17.12
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-377-5p	chr17	5489947	5489953	7mer-m8	5489933	5489954	155	-19.35
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6086	chr17	5489947	5489953	7mer-m8	5489935	5489954	148	-19
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6516-5p	chr17	5489943	5489949	7mer-m8	5489925	5489950	152	-16.76
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-377-5p	chr17	5489947	5489953	7mer-m8	5489933	5489954	155	-19.35
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6086	chr17	5489947	5489953	7mer-m8	5489935	5489954	148	-19
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6516-5p	chr17	5489943	5489949	7mer-m8	5489925	5489950	152	-16.76
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-377-5p	chr17	5489947	5489953	7mer-m8	5489933	5489954	155	-19.35
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6086	chr17	5489947	5489953	7mer-m8	5489935	5489954	148	-19
ADediting_639953	chr17_5489950_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6516-5p	chr17	5489943	5489949	7mer-m8	5489925	5489950	152	-16.76
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-4478	chr17	5489984	5489990	7mer-m8	5489973	5489991	150	-25.92
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-4649-3p	chr17	5489981	5489987	7mer-m8	5489968	5489988	140	-14.11
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-485-5p	chr17	5489985	5489991	7mer-m8	5489970	5489992	153	-16.98
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-7160-5p	chr17	5489982	5489988	7mer-m8	5489969	5489989	146	-17.63
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-4478	chr17	5489984	5489990	7mer-m8	5489973	5489991	150	-25.92
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-4649-3p	chr17	5489981	5489987	7mer-m8	5489968	5489988	140	-14.11
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-485-5p	chr17	5489985	5489991	7mer-m8	5489970	5489992	153	-16.98
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-7160-5p	chr17	5489982	5489988	7mer-m8	5489969	5489989	146	-17.63
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-4478	chr17	5489984	5489990	7mer-m8	5489973	5489991	150	-25.92
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-4649-3p	chr17	5489981	5489987	7mer-m8	5489968	5489988	140	-14.11
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-485-5p	chr17	5489985	5489991	7mer-m8	5489970	5489992	153	-16.98
ADediting_639956	chr17_5489987_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-7160-5p	chr17	5489982	5489988	7mer-m8	5489969	5489989	146	-17.63
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-12126	chr17	5489991	5489998	8mer-1a	5489975	5489998	147	-13.08
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-30b-3p	chr17	5489988	5489995	8mer-1a	5489974	5489995	151	-15.38
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-3689a-3p	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-18.72
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-3689b-3p	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-3689c	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-6779-5p	chr17	5489988	5489995	8mer-1a	5489977	5489995	148	-22.58
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-887-5p	chr17	5489989	5489995	7mer-m8	5489977	5489996	143	-19.73
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-12126	chr17	5489991	5489998	8mer-1a	5489975	5489998	147	-13.08
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-30b-3p	chr17	5489988	5489995	8mer-1a	5489974	5489995	151	-15.38
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-3689a-3p	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-18.72
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-3689b-3p	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-3689c	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-6779-5p	chr17	5489988	5489995	8mer-1a	5489977	5489995	148	-22.58
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-887-5p	chr17	5489989	5489995	7mer-m8	5489977	5489996	143	-19.73
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-12126	chr17	5489991	5489998	8mer-1a	5489975	5489998	147	-13.08
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-30b-3p	chr17	5489988	5489995	8mer-1a	5489974	5489995	151	-15.38
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-3689a-3p	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-18.72
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-3689b-3p	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-3689c	chr17	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-6779-5p	chr17	5489988	5489995	8mer-1a	5489977	5489995	148	-22.58
ADediting_639957	chr17_5489995_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-887-5p	chr17	5489989	5489995	7mer-m8	5489977	5489996	143	-19.73
ADediting_639960	chr17_5490049_+	ENSG00000167842.15	ENST00000381165.3	MIS12-201	hsa-miR-544a	chr17	5490042	5490049	8mer-1a	5490024	5490049	146	-15.61
ADediting_639960	chr17_5490049_+	ENSG00000167842.15	ENST00000573759.1	MIS12-202	hsa-miR-544a	chr17	5490042	5490049	8mer-1a	5490024	5490049	146	-15.61
ADediting_639960	chr17_5490049_+	ENSG00000167842.15	ENST00000611091.4	MIS12-206	hsa-miR-544a	chr17	5490042	5490049	8mer-1a	5490024	5490049	146	-15.61

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_639922

chr17_5487143_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-513a-5p

chr17

5487138

5487144

7mer-m8

5487128

5487145

156

-26.34

ADediting_639922

chr17_5487143_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-638

chr17

5487143

5487149

7mer-1a

5487125

5487149

163

-36.81

ADediting_639923

chr17_5487144_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-8052

chr17

5487143

5487149

7mer-1a

5487127

5487149

143

-23.66

ADediting_639924

chr17_5487153_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-1207-3p

chr17

5487147

5487153

7mer-m8

5487137

5487154

140

-12.56

ADediting_639924

chr17_5487153_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-646

chr17

5487149

5487155

7mer-m8

5487138

5487156

145

-16.24

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1547599

chr17_5487149_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-5089-5p

chr17

5487143

5487149

7mer-m8

5487131

5487150

147

-11.91

ADediting_1547599

chr17_5487149_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-6506-5p

chr17

5487144

5487150

7mer-m8

5487129

5487151

144

-14.62

ADediting_639922

chr17_5487143_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-10399-5p

chr17

5487139

5487145

7mer-m8

5487126

5487146

148

-10.86

ADediting_639922

chr17_5487143_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-6504-3p

chr17

5487139

5487145

7mer-m8

5487125

5487146

141

-14.47

ADediting_639923

chr17_5487144_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-10399-5p

chr17

5487139

5487145

7mer-m8

5487126

5487146

148

-10.86

ADediting_639923

chr17_5487144_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-5089-5p

chr17

5487143

5487149

7mer-m8

5487131

5487150

147

-11.91

ADediting_639923

chr17_5487144_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-6504-3p

chr17

5487139

5487145

7mer-m8

5487125

5487146

141

-14.47

ADediting_639924

chr17_5487153_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-562

chr17

5487150

5487156

7mer-m8

5487138

5487157

150

-12.74

ADediting_639924

chr17_5487153_+

ENSG00000167842.15

ENST00000574186.1

MIS12-203

hsa-miR-5697

chr17

5487151

5487157

7mer-m8

5487136

5487158

149

-18.33

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1535953

chr14_101045971_+

ENSG00000167842.15

ENST00000381165.3

MIS12-201

hsa-miR-381-3p

chr17

5489618

5489624

7mer-m8

5489604

5489625

148

-11.5

ADediting_1535953

chr14_101045971_+

ENSG00000167842.15

ENST00000573759.1

MIS12-202

hsa-miR-381-3p

chr17

5489618

5489624

7mer-m8

5489604

5489625

148

-11.5

ADediting_1535953

chr14_101045971_+

ENSG00000167842.15

ENST00000611091.4

MIS12-206

hsa-miR-381-3p

chr17

5489618

5489624

7mer-m8

5489604

5489625

148

-11.5

ADediting_1535954

chr14_101045974_+

ENSG00000167842.15

ENST00000381165.3

MIS12-201

hsa-miR-381-3p

chr17

5489618

5489624

7mer-m8

5489604

5489625

148

-11.5

ADediting_1535954

chr14_101045974_+

ENSG00000167842.15

ENST00000573759.1

MIS12-202

hsa-miR-381-3p

chr17

5489618

5489624

7mer-m8

5489604

5489625

148

-11.5

ADediting_1535954

chr14_101045974_+

ENSG00000167842.15

ENST00000611091.4

MIS12-206

hsa-miR-381-3p

chr17

5489618

5489624

7mer-m8

5489604

5489625

148

-11.5

ADediting_1556067

chr19_40282625_-

ENSG00000167842.15

ENST00000381165.3

MIS12-201

hsa-miR-641

chr17

5490637

5490643

7mer-m8

5490618

5490644

150

-17.61

ADediting_1556067

chr19_40282625_-

ENSG00000167842.15

ENST00000573759.1

MIS12-202

hsa-miR-641

chr17

5490637

5490643

7mer-m8

5490618

5490644

150

-17.61

ADediting_1556067

chr19_40282625_-

ENSG00000167842.15

ENST00000611091.4

MIS12-206

hsa-miR-641

chr17

5490637

5490643

7mer-m8

5490618

5490644

150

-17.61

ADediting_1631458

chr19_40282624_-

ENSG00000167842.15

ENST00000381165.3

MIS12-201

hsa-miR-641

chr17

5490637

5490643

7mer-m8

5490618

5490644

150

-17.61

ADediting_1631458

chr19_40282624_-

ENSG00000167842.15

ENST00000573759.1

MIS12-202

hsa-miR-641

chr17

5490637

5490643

7mer-m8

5490618

5490644

150

-17.61

ADediting_1631458

chr19_40282624_-

ENSG00000167842.15

ENST00000611091.4

MIS12-206

hsa-miR-641

chr17

5490637

5490643

7mer-m8

5490618

5490644

150

-17.61

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for MIS12

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000574186.1	lncRNA
ENST00000611091.4	protein_coding
ENST00000576570.5	protein_coding
ENST00000573759.1	protein_coding
ENST00000381165.3	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_639951	ENST00000611091.4	chr17_5489889_+	1772	-755.20	-751.70	-761.00
ADediting_639952	ENST00000611091.4	chr17_5489944_+	1827	-751.30	-751.70	-761.00
ADediting_639953	ENST00000611091.4	chr17_5489950_+	1833	-751.40	-751.70	-761.00
ADediting_639954	ENST00000611091.4	chr17_5489969_+	1852	-751.80	-751.70	-761.00
ADediting_639955	ENST00000611091.4	chr17_5489970_+	1853	-752.70	-751.70	-761.00
ADediting_639956	ENST00000611091.4	chr17_5489987_+	1870	-751.00	-751.70	-761.00
ADediting_639957	ENST00000611091.4	chr17_5489995_+	1878	-752.10	-751.70	-761.00
ADediting_639958	ENST00000611091.4	chr17_5490003_+	1886	-752.80	-751.70	-761.00
ADediting_639959	ENST00000611091.4	chr17_5490009_+	1892	-753.60	-751.70	-761.00
ADediting_639960	ENST00000611091.4	chr17_5490049_+	1932	-751.70	-751.70	-761.00
ADediting_639939	ENST00000576570.5	chr17_5487593_+	337	-295.90	-295.50	-322.20
ADediting_639940	ENST00000576570.5	chr17_5487595_+	339	-297.70	-295.50	-322.20
ADediting_639941	ENST00000576570.5	chr17_5487596_+	340	-295.50	-295.50	-322.20
ADediting_639942	ENST00000576570.5	chr17_5487606_+	350	-297.20	-295.50	-322.20
ADediting_639943	ENST00000576570.5	chr17_5487611_+	355	-295.50	-295.50	-322.20
ADediting_639944	ENST00000576570.5	chr17_5487612_+	356	-299.30	-295.50	-322.20
ADediting_639945	ENST00000576570.5	chr17_5487632_+	376	-297.60	-295.50	-322.20
ADediting_639946	ENST00000576570.5	chr17_5487649_+	393	-296.00	-295.50	-322.20
ADediting_639947	ENST00000576570.5	chr17_5487661_+	405	-299.50	-295.50	-322.20
ADediting_639948	ENST00000576570.5	chr17_5487674_+	418	-297.90	-295.50	-322.20
ADediting_639949	ENST00000576570.5	chr17_5487677_+	421	-300.30	-295.50	-322.20
ADediting_639951	ENST00000573759.1	chr17_5489889_+	1356	-593.10	-589.60	-604.80
ADediting_639952	ENST00000573759.1	chr17_5489944_+	1411	-589.20	-589.60	-604.80
ADediting_639953	ENST00000573759.1	chr17_5489950_+	1417	-589.30	-589.60	-604.80
ADediting_639954	ENST00000573759.1	chr17_5489969_+	1436	-590.10	-589.60	-604.80
ADediting_639955	ENST00000573759.1	chr17_5489970_+	1437	-592.30	-589.60	-604.80
ADediting_639956	ENST00000573759.1	chr17_5489987_+	1454	-589.70	-589.60	-604.80
ADediting_639957	ENST00000573759.1	chr17_5489995_+	1462	-590.30	-589.60	-604.80
ADediting_639958	ENST00000573759.1	chr17_5490003_+	1470	-593.00	-589.60	-604.80
ADediting_639959	ENST00000573759.1	chr17_5490009_+	1476	-591.60	-589.60	-604.80
ADediting_639960	ENST00000573759.1	chr17_5490049_+	1516	-590.40	-589.60	-604.80
ADediting_639951	ENST00000381165.3	chr17_5489889_+	1580	-675.10	-671.60	-680.60
ADediting_639952	ENST00000381165.3	chr17_5489944_+	1635	-671.20	-671.60	-680.60
ADediting_639953	ENST00000381165.3	chr17_5489950_+	1641	-671.30	-671.60	-680.60
ADediting_639954	ENST00000381165.3	chr17_5489969_+	1660	-671.70	-671.60	-680.60
ADediting_639955	ENST00000381165.3	chr17_5489970_+	1661	-672.60	-671.60	-680.60
ADediting_639956	ENST00000381165.3	chr17_5489987_+	1678	-670.90	-671.60	-680.60
ADediting_639957	ENST00000381165.3	chr17_5489995_+	1686	-672.00	-671.60	-680.60
ADediting_639958	ENST00000381165.3	chr17_5490003_+	1694	-672.70	-671.60	-680.60
ADediting_639959	ENST00000381165.3	chr17_5490009_+	1700	-673.50	-671.60	-680.60
ADediting_639960	ENST00000381165.3	chr17_5490049_+	1740	-671.60	-671.60	-680.60

RNA A-to-I editing in lncRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_639922	ENST00000574186.1	chr17_5487143_+	251	-78.40	-77.50	-80.60
ADediting_639923	ENST00000574186.1	chr17_5487144_+	252	-80.10	-77.50	-80.60
ADediting_1547599	ENST00000574186.1	chr17_5487149_+	257	-76.70	-77.50	-80.60
ADediting_639924	ENST00000574186.1	chr17_5487153_+	261	-77.50	-77.50	-80.60

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Relation with ADAR for MIS12

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_639936	chr17_5487325_+	1.41334586540237e-06	0.381964575489816	0.000763187696175481	0.271895794506579	0.716692183205978	0.0298725675741736
TCX	ADediting_639936	chr17_5487325_+	7.15227950950001e-05	0.318426635859809	0.0407527172143437	0.167278591743469	0.991212481202554	-0.000906854554649447
TCX	ADediting_639937	chr17_5487377_+	0.0107397828415424	0.207752812208965	0.485099232295991	-0.0574350322861233	7.65173307019964e-05	0.317202448265039
CER	ADediting_639939	chr17_5487593_+	3.26664037051407e-05	0.33226756448354	0.0148750243793043	0.198527518064537	0.928584276685737	-0.00737958143696649
CER	ADediting_639941	chr17_5487596_+	0.000179139808825663	0.301301045887572	0.0427255938566824	0.16569407194593	0.860574049857253	-0.0144614562160557
DLPFC	ADediting_639948	chr17_5487674_+	0.00326305752866383	0.166587210850493	0.419899377255101	0.0459730574686324	1.55284906453018e-09	0.334406218498139
CER	ADediting_639948	chr17_5487674_+	6.29581431310409e-06	0.359358561288429	0.0327207215523011	0.174482135717833	0.825019304397616	0.0182030239524864
CER	ADediting_639953	chr17_5489950_+	0.0458780232327607	0.163284867420635	8.09466786432456e-06	0.355381412068185	0.00192202083818817	0.251304081910258
CER	ADediting_639955	chr17_5489970_+	0.0920584606647417	0.138045565446964	1.22391592391949e-05	0.348720031856605	0.00135871427006035	0.259229493866126
CER	ADediting_639958	chr17_5490003_+	0.0462858350640154	0.162983380248901	2.22098308030177e-07	0.407809190653949	0.275237326888676	0.0896568494676224
CER	ADediting_639959	chr17_5490009_+	0.0253413533635218	0.182571527612586	0.000147920725342977	0.304960223292475	0.0166955910179728	0.195165364914412

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	7.23110446875216e-36	0.631255030624302	2.15781738245195e-27	0.563662645054312	4.92603290669509e-06	0.256134069100943
AC	2.13647304096468e-55	0.793426809263385	2.30064848084353e-30	0.641324674349951	5.84372748816322e-22	0.559110201634282
PCC	1.79150713486762e-12	0.48140725965934	3.62514355949435e-12	0.475498026163363	0.00265960139631237	0.216244036604955
CER	2.47100221006566e-21	0.6755840812085	7.02826068008944e-07	0.391980503831349	0.0624187021685392	0.152523140337617
TCX	4.54224779642133e-13	0.546760941220499	0.83756427467718	0.0168790086395497	4.83260885282797e-19	0.64543979193546
FP	1.56720806439762e-17	0.582111155320165	4.68718658350691e-21	0.629738343574605	2.52737223745806e-06	0.344303670642745
IFG	0.373887570761632	0.18579954964226	0.942877425098835	0.0151032199669204	0.0260095371573607	0.444474783342321
PG	2.31238398854054e-34	0.746318841669685	2.35393217659327e-20	0.610177236308971	0.250008904966456	0.0847656566170678
STG	7.88938369631466e-09	0.579110329219663	6.45558181002781e-07	0.51191443610946	0.00605033284544491	0.297163377332941

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Relation with AD stages for MIS12

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_639958	chr17_5490003_+	3.01620051981457e-05	0.389995243788422

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
TCX	1.3331459420755e-07	0.485443044345687

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RelatedDrugs for MIS12

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MIS12

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MIS12	C0023893	Liver Cirrhosis, Experimental	1	CTD_human

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Gene summary for MIS12

RNA A-to-I events for MIS12

RNA editing positional annotations for MIS12 using Annovar

RNA A-to-I editing events in the alternative splicing sites for MIS12

Differntial gene expression between RNA A-to-I edited versus non-edited samples for MIS12

Protein coding region RNA A-to-I editings for MIS12

The effects of the RNA editing to the miRNA binding sites for MIS12

The effects of the RNA editing to the stability of the RNA structures for MIS12

Relation with ADAR for MIS12

Relation with AD stages for MIS12

RelatedDrugs for MIS12

RelatedDiseases for MIS12

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene