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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for MIS12

check button Gene summary
Gene informationGene symbol

MIS12

Gene ID

79003

Gene nameMIS12 kinetochore complex component
Synonyms2510025F08Rik|KNTC2AP|MTW1|hMis12
Cytomap

17p13.2

Type of geneprotein-coding
Descriptionprotein MIS12 homologMIS12 homologMIS12, MIND kinetochore complex component, homologhomolog of yeast Mis12
Modification date20200313
UniProtAcc

Q9H081,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
MIS12

GO:0051382

kinetochore assembly

16585270


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RNA A-to-I events for MIS12

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_639922(5487143, +), ADediting_639923(5487144, +), ADediting_639924(5487153, +), ADediting_639925(5487171, +), ADediting_639926(5487179, +), ADediting_639927(5487185, +), ADediting_639928(5487196, +), ADediting_639929(5487221, +), ADediting_639930(5487266, +), ADediting_639931(5487269, +), ADediting_639932(5487272, +), ADediting_639933(5487289, +), ADediting_639934(5487297, +), ADediting_639935(5487309, +), ADediting_639936(5487325, +), ADediting_639937(5487377, +), ADediting_639938(5487396, +), ADediting_639939(5487593, +), ADediting_639940(5487595, +), ADediting_639941(5487596, +), ADediting_639942(5487606, +), ADediting_639943(5487611, +), ADediting_639944(5487612, +), ADediting_639945(5487632, +), ADediting_639946(5487649, +), ADediting_639947(5487661, +), ADediting_639948(5487674, +), ADediting_639949(5487677, +), ADediting_639950(5487698, +), ADediting_639951(5489889, +), ADediting_639952(5489944, +), ADediting_639953(5489950, +), ADediting_639954(5489969, +), ADediting_639955(5489970, +), ADediting_639956(5489987, +), ADediting_639957(5489995, +), ADediting_639958(5490003, +), ADediting_639959(5490009, +), ADediting_639960(5490049, +), ADediting_1547599(5487149, +), ADediting_1547600(5487184, +), ADediting_1547601(5487189, +), ADediting_1547602(5487286, +), ADediting_1547603(5487332, +),

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RNA editing positional annotations for MIS12 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_639922chr17_5487143_+intronic
ADediting_639923chr17_5487144_+intronic
ADediting_639924chr17_5487153_+intronic
ADediting_639925chr17_5487171_+intronic
ADediting_639926chr17_5487179_+intronic
ADediting_639927chr17_5487185_+intronic
ADediting_639928chr17_5487196_+intronic
ADediting_639929chr17_5487221_+intronic
ADediting_639930chr17_5487266_+intronic
ADediting_639931chr17_5487269_+intronic
ADediting_639932chr17_5487272_+intronic
ADediting_639933chr17_5487289_+intronic
ADediting_639934chr17_5487297_+intronic
ADediting_639935chr17_5487309_+intronic
ADediting_639936chr17_5487325_+intronic
ADediting_639937chr17_5487377_+intronic
ADediting_639938chr17_5487396_+intronic
ADediting_639939chr17_5487593_+UTR5
ADediting_639940chr17_5487595_+UTR5
ADediting_639941chr17_5487596_+UTR5
ADediting_639942chr17_5487606_+UTR5
ADediting_639943chr17_5487611_+UTR5
ADediting_639944chr17_5487612_+UTR5
ADediting_639945chr17_5487632_+UTR5
ADediting_639946chr17_5487649_+UTR5
ADediting_639947chr17_5487661_+UTR5
ADediting_639948chr17_5487674_+UTR5
ADediting_639949chr17_5487677_+UTR5
ADediting_639950chr17_5487698_+intronic
ADediting_639951chr17_5489889_+UTR3
ADediting_639952chr17_5489944_+UTR3
ADediting_639953chr17_5489950_+UTR3
ADediting_639954chr17_5489969_+UTR3
ADediting_639955chr17_5489970_+UTR3
ADediting_639956chr17_5489987_+UTR3
ADediting_639957chr17_5489995_+UTR3
ADediting_639958chr17_5490003_+UTR3
ADediting_639959chr17_5490009_+UTR3
ADediting_639960chr17_5490049_+UTR3
ADediting_1547599chr17_5487149_+intronic
ADediting_1547600chr17_5487184_+intronic
ADediting_1547601chr17_5487189_+intronic
ADediting_1547602chr17_5487286_+intronic
ADediting_1547603chr17_5487332_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_639922chr17_5487143_+SINEAluName=AluJb
ADediting_639923chr17_5487144_+SINEAluName=AluJb
ADediting_639924chr17_5487153_+SINEAluName=AluJb
ADediting_639925chr17_5487171_+SINEAluName=AluJb
ADediting_639926chr17_5487179_+SINEAluName=AluJb
ADediting_639927chr17_5487185_+SINEAluName=AluJb
ADediting_639928chr17_5487196_+SINEAluName=AluJb
ADediting_639929chr17_5487221_+SINEAluName=AluJb
ADediting_639930chr17_5487266_+SINEAluName=AluJb
ADediting_639931chr17_5487269_+SINEAluName=AluJb
ADediting_639932chr17_5487272_+SINEAluName=AluJb
ADediting_639933chr17_5487289_+SINEAluName=AluJb
ADediting_639934chr17_5487297_+SINEAluName=AluJb
ADediting_639935chr17_5487309_+SINEAluName=AluJb
ADediting_639936chr17_5487325_+SINEAluName=AluJb
ADediting_639937chr17_5487377_+SINEAluName=AluJb
ADediting_639938chr17_5487396_+SINEAluName=AluJb
ADediting_639939chr17_5487593_+SINEAluName=AluSx1
ADediting_639940chr17_5487595_+SINEAluName=AluSx1
ADediting_639941chr17_5487596_+SINEAluName=AluSx1
ADediting_639942chr17_5487606_+SINEAluName=AluSx1
ADediting_639943chr17_5487611_+SINEAluName=AluSx1
ADediting_639944chr17_5487612_+SINEAluName=AluSx1
ADediting_639945chr17_5487632_+SINEAluName=AluSx1
ADediting_639946chr17_5487649_+SINEAluName=AluSx1
ADediting_639947chr17_5487661_+SINEAluName=AluSx1
ADediting_639948chr17_5487674_+SINEAluName=AluSx1
ADediting_639949chr17_5487677_+SINEAluName=AluSx1
ADediting_639950chr17_5487698_+SINEAluName=AluSx1
ADediting_639951chr17_5489889_+SINEAluName=AluJr4
ADediting_639952chr17_5489944_+SINEAluName=AluJr4
ADediting_639953chr17_5489950_+SINEAluName=AluJr4
ADediting_639954chr17_5489969_+SINEAluName=AluJr4
ADediting_639955chr17_5489970_+SINEAluName=AluJr4
ADediting_639956chr17_5489987_+SINEAluName=AluJr4
ADediting_639957chr17_5489995_+SINEAluName=AluJr4
ADediting_639958chr17_5490003_+SINEAluName=AluJr4
ADediting_639959chr17_5490009_+SINEAluName=AluJr4
ADediting_639960chr17_5490049_+SINEAluName=AluJr4
ADediting_1547599chr17_5487149_+SINEAluName=AluJb
ADediting_1547600chr17_5487184_+SINEAluName=AluJb
ADediting_1547601chr17_5487189_+SINEAluName=AluJb
ADediting_1547602chr17_5487286_+SINEAluName=AluJb
ADediting_1547603chr17_5487332_+SINEAluName=AluJb

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RNA A-to-I editing events in the alternative splicing sites for MIS12

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MIS12

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs