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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

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Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for TRIR

check button Gene summary
Gene informationGene symbol

TRIR

Gene ID

79002

Gene nametelomerase RNA component interacting RNase
SynonymsC19orf43|TERCIR|fSAP18
Cytomap

19p13.13

Type of geneprotein-coding
Descriptiontelomerase RNA component interacting RNaseMy029 proteinexoribonuclease TRIRuncharacterized protein C19orf43
Modification date20200313
UniProtAcc

Q9BQ61,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TRIR

GO:0016075

rRNA catabolic process

28322335

TRIR

GO:0090503

RNA phosphodiester bond hydrolysis, exonucleolytic

28322335


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RNA A-to-I events for TRIR

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_711284(12731864, -), ADediting_711285(12731866, -), ADediting_711286(12731878, -), ADediting_711287(12731879, -), ADediting_711288(12731880, -), ADediting_711289(12731887, -), ADediting_711290(12731897, -), ADediting_711291(12731906, -), ADediting_711292(12731918, -), ADediting_711293(12731919, -), ADediting_711294(12731920, -), ADediting_711295(12731931, -), ADediting_711296(12731943, -), ADediting_711297(12731957, -), ADediting_711298(12731960, -), ADediting_711299(12731966, -), ADediting_711300(12732002, -), ADediting_711301(12732012, -), ADediting_711302(12732015, -), ADediting_711303(12732016, -), ADediting_711304(12732024, -), ADediting_711305(12732037, -), ADediting_711306(12732038, -), ADediting_711307(12732041, -), ADediting_711308(12732042, -), ADediting_711309(12732048, -), ADediting_711310(12732061, -), ADediting_711311(12732067, -), ADediting_711312(12732077, -), ADediting_711313(12732085, -), ADediting_711314(12732652, -), ADediting_711315(12732655, -), ADediting_711316(12732662, -), ADediting_711317(12732666, -), ADediting_711318(12732686, -), ADediting_711319(12732687, -), ADediting_711320(12732692, -), ADediting_711321(12732701, -), ADediting_711322(12732727, -), ADediting_711323(12732728, -), ADediting_711324(12732750, -), ADediting_711325(12732763, -), ADediting_711326(12732766, -), ADediting_711327(12732767, -), ADediting_711328(12732768, -), ADediting_711329(12732769, -), ADediting_711330(12732772, -), ADediting_711331(12732783, -), ADediting_711332(12732793, -), ADediting_711333(12732803, -), ADediting_711334(12732808, -), ADediting_711335(12732809, -), ADediting_711336(12732832, -), ADediting_711337(12732961, -), ADediting_711338(12732972, -), ADediting_711339(12732996, -), ADediting_711340(12733028, -), ADediting_711341(12733042, -), ADediting_711342(12733081, -), ADediting_711343(12733086, -), ADediting_711344(12733088, -), ADediting_711345(12733091, -), ADediting_711346(12733104, -), ADediting_711347(12733105, -), ADediting_711348(12733122, -), ADediting_711349(12733136, -), ADediting_711350(12733141, -), ADediting_711351(12733142, -), ADediting_711352(12733175, -), ADediting_711353(12733198, -), ADediting_1552387(12731940, -), ADediting_1552388(12732718, -), ADediting_1552389(12733133, -),

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RNA editing positional annotations for TRIR using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_711284chr19_12731864_-intronic
ADediting_711285chr19_12731866_-intronic
ADediting_711286chr19_12731878_-intronic
ADediting_711287chr19_12731879_-intronic
ADediting_711288chr19_12731880_-intronic
ADediting_711289chr19_12731887_-intronic
ADediting_711290chr19_12731897_-intronic
ADediting_711291chr19_12731906_-intronic
ADediting_711292chr19_12731918_-intronic
ADediting_711293chr19_12731919_-intronic
ADediting_711294chr19_12731920_-intronic
ADediting_711295chr19_12731931_-intronic
ADediting_711296chr19_12731943_-intronic
ADediting_711297chr19_12731957_-intronic
ADediting_711298chr19_12731960_-intronic
ADediting_711299chr19_12731966_-intronic
ADediting_711300chr19_12732002_-intronic
ADediting_711301chr19_12732012_-intronic
ADediting_711302chr19_12732015_-intronic
ADediting_711303chr19_12732016_-intronic
ADediting_711304chr19_12732024_-intronic
ADediting_711305chr19_12732037_-intronic
ADediting_711306chr19_12732038_-intronic
ADediting_711307chr19_12732041_-intronic
ADediting_711308chr19_12732042_-intronic
ADediting_711309chr19_12732048_-intronic
ADediting_711310chr19_12732061_-intronic
ADediting_711311chr19_12732067_-intronic
ADediting_711312chr19_12732077_-intronic
ADediting_711313chr19_12732085_-intronic
ADediting_711314chr19_12732652_-intronic
ADediting_711315chr19_12732655_-intronic
ADediting_711316chr19_12732662_-intronic
ADediting_711317chr19_12732666_-intronic
ADediting_711318chr19_12732686_-intronic
ADediting_711319chr19_12732687_-intronic
ADediting_711320chr19_12732692_-intronic
ADediting_711321chr19_12732701_-intronic
ADediting_711322chr19_12732727_-intronic
ADediting_711323chr19_12732728_-intronic
ADediting_711324chr19_12732750_-intronic
ADediting_711325chr19_12732763_-intronic
ADediting_711326chr19_12732766_-intronic
ADediting_711327chr19_12732767_-intronic
ADediting_711328chr19_12732768_-intronic
ADediting_711329chr19_12732769_-intronic
ADediting_711330chr19_12732772_-intronic
ADediting_711331chr19_12732783_-intronic
ADediting_711332chr19_12732793_-intronic
ADediting_711333chr19_12732803_-intronic
ADediting_711334chr19_12732808_-intronic
ADediting_711335chr19_12732809_-intronic
ADediting_711336chr19_12732832_-intronic
ADediting_711337chr19_12732961_-intronic
ADediting_711338chr19_12732972_-intronic
ADediting_711339chr19_12732996_-intronic
ADediting_711340chr19_12733028_-intronic
ADediting_711341chr19_12733042_-intronic
ADediting_711342chr19_12733081_-intronic
ADediting_711343chr19_12733086_-intronic
ADediting_711344chr19_12733088_-intronic
ADediting_711345chr19_12733091_-intronic
ADediting_711346chr19_12733104_-intronic
ADediting_711347chr19_12733105_-intronic
ADediting_711348chr19_12733122_-intronic
ADediting_711349chr19_12733136_-intronic
ADediting_711350chr19_12733141_-intronic
ADediting_711351chr19_12733142_-intronic
ADediting_711352chr19_12733175_-intronic
ADediting_711353chr19_12733198_-intronic
ADediting_1552387chr19_12731940_-intronic
ADediting_1552388chr19_12732718_-intronic
ADediting_1552389chr19_12733133_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_711284chr19_12731864_-SINEAluName=AluSq2
ADediting_711285chr19_12731866_-SINEAluName=AluSq2
ADediting_711286chr19_12731878_-SINEAluName=AluSq2
ADediting_711287chr19_12731879_-SINEAluName=AluSq2
ADediting_711288chr19_12731880_-SINEAluName=AluSq2
ADediting_711289chr19_12731887_-SINEAluName=AluSq2
ADediting_711290chr19_12731897_-SINEAluName=AluSq2
ADediting_711291chr19_12731906_-SINEAluName=AluSq2
ADediting_711292chr19_12731918_-SINEAluName=AluSq2
ADediting_711293chr19_12731919_-SINEAluName=AluSq2
ADediting_711294chr19_12731920_-SINEAluName=AluSq2
ADediting_711295chr19_12731931_-SINEAluName=AluSq2
ADediting_711296chr19_12731943_-SINEAluName=AluSq2
ADediting_711297chr19_12731957_-SINEAluName=AluSq2
ADediting_711298chr19_12731960_-SINEAluName=AluSq2
ADediting_711299chr19_12731966_-SINEAluName=AluSq2
ADediting_711300chr19_12732002_-SINEAluName=AluSq2
ADediting_711301chr19_12732012_-SINEAluName=AluSq2
ADediting_711302chr19_12732015_-SINEAluName=AluSq2
ADediting_711303chr19_12732016_-SINEAluName=AluSq2
ADediting_711304chr19_12732024_-SINEAluName=AluSq2
ADediting_711305chr19_12732037_-SINEAluName=AluSq2
ADediting_711306chr19_12732038_-SINEAluName=AluSq2
ADediting_711307chr19_12732041_-SINEAluName=AluSq2
ADediting_711308chr19_12732042_-SINEAluName=AluSq2
ADediting_711309chr19_12732048_-SINEAluName=AluSq2
ADediting_711310chr19_12732061_-SINEAluName=AluSq2
ADediting_711311chr19_12732067_-SINEAluName=AluSq2
ADediting_711312chr19_12732077_-SINEAluName=AluSq2
ADediting_711313chr19_12732085_-SINEAluName=AluSq2
ADediting_711314chr19_12732652_-SINEAluName=AluSx
ADediting_711315chr19_12732655_-SINEAluName=AluSx
ADediting_711316chr19_12732662_-SINEAluName=AluSx
ADediting_711317chr19_12732666_-SINEAluName=AluSx
ADediting_711318chr19_12732686_-SINEAluName=AluSx
ADediting_711319chr19_12732687_-SINEAluName=AluSx
ADediting_711320chr19_12732692_-SINEAluName=AluSx
ADediting_711321chr19_12732701_-SINEAluName=AluSx
ADediting_711322chr19_12732727_-SINEAluName=AluSx
ADediting_711323chr19_12732728_-SINEAluName=AluSx
ADediting_711324chr19_12732750_-SINEAluName=AluSx
ADediting_711325chr19_12732763_-SINEAluName=AluSx
ADediting_711326chr19_12732766_-SINEAluName=AluSx
ADediting_711327chr19_12732767_-SINEAluName=AluSx
ADediting_711328chr19_12732768_-SINEAluName=AluSx
ADediting_711329chr19_12732769_-SINEAluName=AluSx
ADediting_711330chr19_12732772_-SINEAluName=AluSx
ADediting_711331chr19_12732783_-SINEAluName=AluSx
ADediting_711332chr19_12732793_-SINEAluName=AluSx
ADediting_711333chr19_12732803_-SINEAluName=AluSx
ADediting_711334chr19_12732808_-SINEAluName=AluSx
ADediting_711335chr19_12732809_-SINEAluName=AluSx
ADediting_711336chr19_12732832_-SINEAluName=AluSx
ADediting_711337chr19_12732961_-SINEAluName=AluJo
ADediting_711338chr19_12732972_-SINEAluName=AluJo
ADediting_711339chr19_12732996_-SINEAluName=AluJo
ADediting_711340chr19_12733028_-SINEAluName=AluJo
ADediting_711341chr19_12733042_-SINEAluName=AluJo
ADediting_711342chr19_12733081_-SINEAluName=AluJo
ADediting_711343chr19_12733086_-SINEAluName=AluJo
ADediting_711344chr19_12733088_-SINEAluName=AluJo
ADediting_711345chr19_12733091_-SINEAluName=AluJo
ADediting_711346chr19_12733104_-SINEAluName=AluJo
ADediting_711347chr19_12733105_-SINEAluName=AluJo
ADediting_711348chr19_12733122_-SINEAluName=AluJo
ADediting_711349chr19_12733136_-SINEAluName=AluJo
ADediting_711350chr19_12733141_-SINEAluName=AluJo
ADediting_711351chr19_12733142_-SINEAluName=AluJo
ADediting_711352chr19_12733175_-SINEAluName=AluJo
ADediting_711353chr19_12733198_-SINEAluName=AluJo
ADediting_1552387chr19_12731940_-SINEAluName=AluSq2
ADediting_1552388chr19_12732718_-SINEAluName=AluSx
ADediting_1552389chr19_12733133_-SINEAluName=AluJo

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RNA A-to-I editing events in the alternative splicing sites for TRIR

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TRIR

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for TRIR

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TRIR


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TRIR

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TRIR

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_711286chr19_12731878_-4.28772136638447e-050.2301781699194581.4970529214679e-100.3534365696683690.9169312136183710.00594782191334466
DLPFCADediting_711290chr19_12731897_-0.00037191272355550.2008986752388343.10140127690015e-080.307971424438390.0003203327661120650.203055584244313
DLPFCADediting_711304chr19_12732024_-0.001732048793129350.1772309209451281.52349482357925e-100.3532987778440610.003672928022456560.164529822714199
DLPFCADediting_711305chr19_12732037_-0.002095342289082870.174093463807241.19398580262069e-100.3552108221502610.007810542709359510.150830487555899
DLPFCADediting_711306chr19_12732038_-0.04663851391101520.1130939778193323.1691770122838e-080.307770902548240.003366998100724820.166044217222759
DLPFCADediting_711307chr19_12732041_-0.01714169324041940.1353059293254147.61453109370464e-090.3206885198645090.006202540072617760.155128781445335
DLPFCADediting_711308chr19_12732042_-0.01127736809295760.1437531208361372.57955397548895e-080.3096743017682570.01358867874012150.140044828593119
DLPFCADediting_711310chr19_12732061_-6.15753360040007e-050.2255370515588741.76516452122589e-080.3131471633344520.1040438482276310.0925010941187141
CERADediting_711310chr19_12732061_-0.0340574130327120.1731865105148042.09739324982766e-050.3398082089063190.9394669541642370.0062527090283555
DLPFCADediting_711311chr19_12732067_-1.73990142562651e-050.2413490452631243.79042306114493e-110.3640453421857520.800033157371837-0.0144443122560377
DLPFCADediting_711312chr19_12732077_-3.70864884222571e-050.2320122961439692.4679786436105e-090.3304787706570420.748981697539628-0.0182459734592745
DLPFCADediting_711313chr19_12732085_-0.0006028379514659440.1937630379570943.62476217408774e-110.3643840002660710.002117283224275150.173920327107777
TCXADediting_711350chr19_12733141_-0.8453784540581340.01605648855865080.119759138880436-0.1275769411163272.53398246370074e-080.435585935831737
DLPFCADediting_711352chr19_12733175_-2.79771070027089e-080.308925254675911.78036198425494e-070.291251673490640.001747629603212670.177084506468267
TCXADediting_711353chr19_12733198_-0.04637552308853540.1629173728367290.8362222931196030.01702043122758060.0001907512629828660.300090353889249

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC9.24863332046273e-190.4738931162074531.52439653966636e-230.5268847451651295.06431756050129e-230.521536883117076
AC5.05113291772579e-470.7532455284244787.2530306790028e-370.6913287297956197.71011959970595e-200.534093779620165
PCC6.70653087230277e-210.6105986237042282.69615212696044e-250.6603611384409540.02504459896978550.162122487930608
CER7.38688577059882e-070.3912778273147564.51384095908432e-140.5658451842663130.09234086335160770.137926990345123
TCX6.94879535571856e-080.4229879810726435.1278293709135e-080.4268373361458180.1709651985247270.112372927191751
FP1.27042808238704e-070.3834426766987552.53686244793544e-090.4279873779731750.6768735636195770.0314493145188358
IFG0.006615845366983260.5284477983047630.002798156789960010.5722483647290.640485923644495-0.0982053096334011
PG1.97216296781201e-140.52268407479271.46832149536427e-070.3738751301682050.1253437067595580.112786251790388
STG4.06925978202922e-120.6675386908364122.14093350221876e-070.5301783683705360.1389863125355990.162795276891572

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Relation with AD stages for TRIR

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for TRIR

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIR

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource