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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ZNF28 |
 Gene summary |
| Gene information | Gene symbol | ZNF28 | Gene ID | 7576 |
| Gene name | zinc finger protein 28 | |
| Synonyms | KOX24 | |
| Cytomap | 19q13.41 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 28zinc finger protein KOX24 | |
| Modification date | 20200320 | |
| UniProtAcc | P17035, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for ZNF28 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_779839(52797866, -), ADediting_779840(52797871, -), ADediting_779841(52797933, -), ADediting_779842(52798046, -), ADediting_779843(52798059, -), ADediting_779844(52798062, -), ADediting_779845(52798281, -), ADediting_779846(52802858, -), ADediting_779848(52805161, -), ADediting_779849(52805170, -), ADediting_779850(52805184, -), ADediting_779851(52805187, -), ADediting_779852(52805194, -), ADediting_779853(52805239, -), ADediting_779854(52805540, -), ADediting_779855(52805541, -), ADediting_779856(52805544, -), ADediting_779857(52805928, -), ADediting_779896(52839008, -), ADediting_779897(52839009, -), ADediting_779898(52839017, -), ADediting_779899(52839063, -), ADediting_779900(52839310, -), ADediting_779901(52839344, -), ADediting_779902(52839348, -), ADediting_779903(52839353, -), ADediting_779904(52839354, -), ADediting_779905(52839375, -), ADediting_779906(52845228, -), ADediting_1558409(52797955, -), ADediting_1558410(52802247, -), ADediting_1558411(52802432, -), ADediting_1558412(52803148, -), ADediting_1558413(52803710, -), ADediting_1558414(52803791, -), ADediting_1558415(52803815, -), ADediting_1558416(52803831, -), ADediting_1558417(52803837, -), ADediting_1558418(52804343, -), ADediting_1558419(52804350, -), ADediting_1558420(52804439, -), ADediting_1558421(52804463, -), ADediting_1558422(52804482, -), ADediting_1558423(52804643, -), ADediting_1558424(52804660, -), ADediting_1558425(52804732, -), ADediting_1558426(52804747, -), ADediting_1558427(52804756, -), ADediting_1558428(52806358, -), ADediting_1558429(52806699, -), ADediting_1558430(52806736, -), ADediting_1558431(52806739, -), ADediting_1558432(52806845, -), ADediting_1558433(52806858, -), ADediting_1558434(52806876, -), ADediting_1558435(52806901, -), ADediting_1558436(52845204, -), ADediting_1558437(52845218, -), |
Top |
RNA editing positional annotations for ZNF28 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_779848 | chr19_52805161_- | nonsynonymous SNV | ENST00000594602.5 | c.A244G | p.S82G | . | . | . |
| ADediting_779848 | chr19_52805161_- | nonsynonymous SNV | ENST00000339844.6 | c.A136G | p.S46G | . | . | . |
| ADediting_779849 | chr19_52805170_- | nonsynonymous SNV | ENST00000594602.5 | c.A235G | p.S79G | . | . | . |
| ADediting_779849 | chr19_52805170_- | nonsynonymous SNV | ENST00000339844.6 | c.A127G | p.S43G | . | . | . |
| ADediting_779850 | chr19_52805184_- | nonsynonymous SNV | ENST00000594602.5 | c.A221G | p.Q74R | . | . | . |
| ADediting_779850 | chr19_52805184_- | nonsynonymous SNV | ENST00000596559.5 | c.A94G | p.N32D | . | . | . |
| ADediting_779850 | chr19_52805184_- | nonsynonymous SNV | ENST00000339844.6 | c.A113G | p.Q38R | . | . | . |
| ADediting_779851 | chr19_52805187_- | nonsynonymous SNV | ENST00000594602.5 | c.A218G | p.K73R | . | . | . |
| ADediting_779851 | chr19_52805187_- | nonsynonymous SNV | ENST00000596559.5 | c.A91G | p.S31G | . | . | . |
| ADediting_779851 | chr19_52805187_- | nonsynonymous SNV | ENST00000339844.6 | c.A110G | p.K37R | . | . | . |
| ADediting_779852 | chr19_52805194_- | nonsynonymous SNV | ENST00000594602.5 | c.A211G | p.R71G | . | . | . |
| ADediting_779852 | chr19_52805194_- | nonsynonymous SNV | ENST00000339844.6 | c.A103G | p.R35G | . | . | . |
| ADediting_779853 | chr19_52805239_- | nonsynonymous SNV | ENST00000594602.5 | c.A166G | p.K56E | . | . | . |
| ADediting_779853 | chr19_52805239_- | nonsynonymous SNV | ENST00000339844.6 | c.A58G | p.K20E | . | . | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_779839 | chr19_52797866_- | UTR3 |
| ADediting_779840 | chr19_52797871_- | UTR3 |
| ADediting_779841 | chr19_52797933_- | UTR3 |
| ADediting_779842 | chr19_52798046_- | UTR3 |
| ADediting_779843 | chr19_52798059_- | UTR3 |
| ADediting_779844 | chr19_52798062_- | UTR3 |
| ADediting_779845 | chr19_52798281_- | UTR3 |
| ADediting_779846 | chr19_52802858_- | intronic |
| ADediting_779848 | chr19_52805161_- | exonic |
| ADediting_779849 | chr19_52805170_- | exonic |
| ADediting_779850 | chr19_52805184_- | exonic |
| ADediting_779851 | chr19_52805187_- | exonic |
| ADediting_779852 | chr19_52805194_- | exonic |
| ADediting_779853 | chr19_52805239_- | exonic |
| ADediting_779854 | chr19_52805540_- | UTR5 |
| ADediting_779855 | chr19_52805541_- | UTR5 |
| ADediting_779856 | chr19_52805544_- | UTR5 |
| ADediting_779857 | chr19_52805928_- | UTR5 |
| ADediting_779896 | chr19_52839008_- | UTR3 |
| ADediting_779897 | chr19_52839009_- | UTR3 |
| ADediting_779898 | chr19_52839017_- | UTR3 |
| ADediting_779899 | chr19_52839063_- | UTR3 |
| ADediting_779900 | chr19_52839310_- | UTR3 |
| ADediting_779901 | chr19_52839344_- | UTR3 |
| ADediting_779902 | chr19_52839348_- | UTR3 |
| ADediting_779903 | chr19_52839353_- | UTR3 |
| ADediting_779904 | chr19_52839354_- | UTR3 |
| ADediting_779905 | chr19_52839375_- | UTR3 |
| ADediting_779906 | chr19_52845228_- | exonic |
| ADediting_1558409 | chr19_52797955_- | UTR3 |
| ADediting_1558410 | chr19_52802247_- | intronic |
| ADediting_1558411 | chr19_52802432_- | intronic |
| ADediting_1558412 | chr19_52803148_- | intronic |
| ADediting_1558413 | chr19_52803710_- | intronic |
| ADediting_1558414 | chr19_52803791_- | intronic |
| ADediting_1558415 | chr19_52803815_- | intronic |
| ADediting_1558416 | chr19_52803831_- | intronic |
| ADediting_1558417 | chr19_52803837_- | intronic |
| ADediting_1558418 | chr19_52804343_- | intronic |
| ADediting_1558419 | chr19_52804350_- | intronic |
| ADediting_1558420 | chr19_52804439_- | intronic |
| ADediting_1558421 | chr19_52804463_- | intronic |
| ADediting_1558422 | chr19_52804482_- | intronic |
| ADediting_1558423 | chr19_52804643_- | intronic |
| ADediting_1558424 | chr19_52804660_- | intronic |
| ADediting_1558425 | chr19_52804732_- | intronic |
| ADediting_1558426 | chr19_52804747_- | intronic |
| ADediting_1558427 | chr19_52804756_- | intronic |
| ADediting_1558428 | chr19_52806358_- | intronic |
| ADediting_1558429 | chr19_52806699_- | intronic |
| ADediting_1558430 | chr19_52806736_- | intronic |
| ADediting_1558431 | chr19_52806739_- | intronic |
| ADediting_1558432 | chr19_52806845_- | intronic |
| ADediting_1558433 | chr19_52806858_- | intronic |
| ADediting_1558434 | chr19_52806876_- | intronic |
| ADediting_1558435 | chr19_52806901_- | intronic |
| ADediting_1558436 | chr19_52845204_- | exonic |
| ADediting_1558437 | chr19_52845218_- | exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_779839 | chr19_52797866_- | SINE | Alu | Name=AluSc8 |
| ADediting_779840 | chr19_52797871_- | SINE | Alu | Name=AluSc8 |
| ADediting_779841 | chr19_52797933_- | SINE | Alu | Name=AluSc8 |
| ADediting_779842 | chr19_52798046_- | SINE | Alu | Name=AluSc8 |
| ADediting_779843 | chr19_52798059_- | SINE | Alu | Name=AluSc8 |
| ADediting_779844 | chr19_52798062_- | SINE | Alu | Name=AluSc8 |
| ADediting_779845 | chr19_52798281_- | SINE | Alu | Name=AluSz |
| ADediting_779846 | chr19_52802858_- | SINE | Alu | Name=AluYj4 |
| ADediting_779848 | chr19_52805161_- | SINE | Alu | Name=AluSc8 |
| ADediting_779849 | chr19_52805170_- | SINE | Alu | Name=AluSc8 |
| ADediting_779850 | chr19_52805184_- | SINE | Alu | Name=AluSc8 |
| ADediting_779851 | chr19_52805187_- | SINE | Alu | Name=AluSc8 |
| ADediting_779852 | chr19_52805194_- | SINE | Alu | Name=AluSc8 |
| ADediting_779853 | chr19_52805239_- | SINE | Alu | Name=AluSc8 |
| ADediting_779854 | chr19_52805540_- | SINE | Alu | Name=AluSc |
| ADediting_779855 | chr19_52805541_- | SINE | Alu | Name=AluSc |
| ADediting_779856 | chr19_52805544_- | SINE | Alu | Name=AluSc |
| ADediting_779857 | chr19_52805928_- | SINE | Alu | Name=AluSq2 |
| ADediting_779896 | chr19_52839008_- | SINE | Alu | Name=AluSc8 |
| ADediting_779897 | chr19_52839009_- | SINE | Alu | Name=AluSc8 |
| ADediting_779898 | chr19_52839017_- | SINE | Alu | Name=AluSc8 |
| ADediting_779899 | chr19_52839063_- | SINE | Alu | Name=AluSc8 |
| ADediting_779900 | chr19_52839310_- | SINE | Alu | Name=AluSx |
| ADediting_779901 | chr19_52839344_- | SINE | Alu | Name=AluSx |
| ADediting_779902 | chr19_52839348_- | SINE | Alu | Name=AluSx |
| ADediting_779903 | chr19_52839353_- | SINE | Alu | Name=AluSx |
| ADediting_779904 | chr19_52839354_- | SINE | Alu | Name=AluSx |
| ADediting_779905 | chr19_52839375_- | SINE | Alu | Name=AluSx |
| ADediting_779906 | chr19_52845228_- | SINE | Alu | Name=AluSc8 |
| ADediting_1558409 | chr19_52797955_- | SINE | Alu | Name=AluSc8 |
| ADediting_1558410 | chr19_52802247_- | SINE | Alu | Name=AluSx4 |
| ADediting_1558411 | chr19_52802432_- | SINE | Alu | Name=AluSx1 |
| ADediting_1558412 | chr19_52803148_- | SINE | Alu | Name=AluSx |
| ADediting_1558413 | chr19_52803710_- | SINE | Alu | Name=AluSx1 |
| ADediting_1558414 | chr19_52803791_- | SINE | Alu | Name=AluSx1 |
| ADediting_1558415 | chr19_52803815_- | SINE | Alu | Name=AluSx1 |
| ADediting_1558416 | chr19_52803831_- | SINE | Alu | Name=AluSx1 |
| ADediting_1558417 | chr19_52803837_- | SINE | Alu | Name=AluSx1 |
| ADediting_1558418 | chr19_52804343_- | SINE | Alu | Name=AluSz |
| ADediting_1558419 | chr19_52804350_- | SINE | Alu | Name=AluSz |
| ADediting_1558420 | chr19_52804439_- | SINE | Alu | Name=AluSz |
| ADediting_1558421 | chr19_52804463_- | SINE | Alu | Name=AluSz |
| ADediting_1558422 | chr19_52804482_- | SINE | Alu | Name=AluSz |
| ADediting_1558423 | chr19_52804643_- | SINE | Alu | Name=AluSz |
| ADediting_1558424 | chr19_52804660_- | SINE | Alu | Name=AluSz |
| ADediting_1558425 | chr19_52804732_- | SINE | Alu | Name=AluSz |
| ADediting_1558426 | chr19_52804747_- | SINE | Alu | Name=AluSz |
| ADediting_1558427 | chr19_52804756_- | SINE | Alu | Name=AluSz |
| ADediting_1558428 | chr19_52806358_- | SINE | Alu | Name=AluSx1 |
| ADediting_1558429 | chr19_52806699_- | SINE | Alu | Name=AluSz |
| ADediting_1558430 | chr19_52806736_- | SINE | Alu | Name=AluSz |
| ADediting_1558431 | chr19_52806739_- | SINE | Alu | Name=AluSz |
| ADediting_1558432 | chr19_52806845_- | SINE | Alu | Name=AluSz |
| ADediting_1558433 | chr19_52806858_- | SINE | Alu | Name=AluSz |
| ADediting_1558434 | chr19_52806876_- | SINE | Alu | Name=AluSz |
| ADediting_1558435 | chr19_52806901_- | SINE | Alu | Name=AluSz |
| ADediting_1558436 | chr19_52845204_- | SINE | Alu | Name=AluSc8 |
| ADediting_1558437 | chr19_52845218_- | SINE | Alu | Name=AluSc8 |
Top |
RNA A-to-I editing events in the alternative splicing sites for ZNF28 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF28 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
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| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for ZNF28 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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Top |
The effects of the RNA editing to the miRNA binding sites for ZNF28 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_779840 | chr19_52797871_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-7977 | chr19 | 52797869 | 52797875 | 7mer-m8 | 52797868 | 52797885 | 140 | -15.95 |
| ADediting_779840 | chr19_52797871_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-7977 | chr19 | 52797869 | 52797875 | 7mer-m8 | 52797868 | 52797885 | 140 | -15.95 |
| ADediting_779841 | chr19_52797933_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-1972 | chr19 | 52797928 | 52797934 | 7mer-m8 | 52797927 | 52797947 | 164 | -30.74 |
| ADediting_779841 | chr19_52797933_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-1972 | chr19 | 52797928 | 52797934 | 7mer-m8 | 52797927 | 52797947 | 164 | -30.74 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-1247-3p | chr19 | 52798044 | 52798050 | 7mer-m8 | 52798043 | 52798065 | 152 | -23.21 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-1247-3p | chr19 | 52798044 | 52798050 | 7mer-m8 | 52798043 | 52798065 | 152 | -23.21 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-20b-3p | chr19 | 52798059 | 52798065 | 7mer-m8 | 52798058 | 52798078 | 141 | -12.55 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-485-5p | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798075 | 148 | -18.54 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-6884-5p | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798076 | 150 | -18.66 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-20b-3p | chr19 | 52798059 | 52798065 | 7mer-m8 | 52798058 | 52798078 | 141 | -12.55 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-485-5p | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798075 | 148 | -18.54 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-6884-5p | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798076 | 150 | -18.66 |
| ADediting_779844 | chr19_52798062_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-6516-5p | chr19 | 52798059 | 52798065 | 7mer-m8 | 52798058 | 52798081 | 145 | -13.05 |
| ADediting_779844 | chr19_52798062_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-6516-5p | chr19 | 52798059 | 52798065 | 7mer-m8 | 52798058 | 52798081 | 145 | -13.05 |
| ADediting_779845 | chr19_52798281_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-4634 | chr19 | 52798277 | 52798283 | 7mer-m8 | 52798276 | 52798299 | 147 | -29.32 |
| ADediting_779845 | chr19_52798281_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-4634 | chr19 | 52798277 | 52798283 | 7mer-m8 | 52798276 | 52798299 | 147 | -29.32 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_779840 | chr19_52797871_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-216a-5p | chr19 | 52797866 | 52797873 | 8mer-1a | 52797866 | 52797887 | 150 | -17.02 |
| ADediting_779840 | chr19_52797871_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-216a-5p | chr19 | 52797866 | 52797873 | 8mer-1a | 52797866 | 52797887 | 150 | -17.02 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-3689a-3p | chr19 | 52798046 | 52798052 | 7mer-m8 | 52798045 | 52798065 | 154 | -27.42 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-490-3p | chr19 | 52798042 | 52798048 | 7mer-m8 | 52798041 | 52798063 | 146 | -16.15 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-6779-5p | chr19 | 52798046 | 52798052 | 7mer-m8 | 52798045 | 52798063 | 152 | -25.72 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-6780a-5p | chr19 | 52798046 | 52798052 | 7mer-m8 | 52798045 | 52798068 | 143 | -21.2 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-3689a-3p | chr19 | 52798046 | 52798052 | 7mer-m8 | 52798045 | 52798065 | 154 | -27.42 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-490-3p | chr19 | 52798042 | 52798048 | 7mer-m8 | 52798041 | 52798063 | 146 | -16.15 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-6779-5p | chr19 | 52798046 | 52798052 | 7mer-m8 | 52798045 | 52798063 | 152 | -25.72 |
| ADediting_779842 | chr19_52798046_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-6780a-5p | chr19 | 52798046 | 52798052 | 7mer-m8 | 52798045 | 52798068 | 143 | -21.2 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-377-5p | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798075 | 151 | -15.56 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-6086 | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798074 | 145 | -20.42 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-377-5p | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798075 | 151 | -15.56 |
| ADediting_779843 | chr19_52798059_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-6086 | chr19 | 52798055 | 52798061 | 7mer-m8 | 52798054 | 52798074 | 145 | -20.42 |
| ADediting_779844 | chr19_52798062_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-921 | chr19 | 52798062 | 52798068 | 7mer-m8 | 52798061 | 52798084 | 147 | -14.13 |
| ADediting_779844 | chr19_52798062_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-921 | chr19 | 52798062 | 52798068 | 7mer-m8 | 52798061 | 52798084 | 147 | -14.13 |
| ADediting_779845 | chr19_52798281_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-6807-5p | chr19 | 52798281 | 52798287 | 7mer-m8 | 52798280 | 52798303 | 142 | -18.14 |
| ADediting_779845 | chr19_52798281_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-6807-5p | chr19 | 52798281 | 52798287 | 7mer-m8 | 52798280 | 52798303 | 142 | -18.14 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-589-3p | chr19 | 52798103 | 52798109 | 7mer-m8 | 52798102 | 52798128 | 150 | -18.44 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-589-3p | chr19 | 52798103 | 52798109 | 7mer-m8 | 52798102 | 52798128 | 150 | -18.44 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-337-3p | chr19 | 52798613 | 52798619 | 7mer-m8 | 52798612 | 52798633 | 166 | -26.16 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-337-3p | chr19 | 52798613 | 52798619 | 7mer-m8 | 52798612 | 52798633 | 166 | -26.16 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-5585-3p | chr19 | 52799539 | 52799545 | 7mer-m8 | 52799538 | 52799562 | 166 | -24.4 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-5585-3p | chr19 | 52799539 | 52799545 | 7mer-m8 | 52799538 | 52799562 | 166 | -24.4 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-381-3p | chr19 | 52799638 | 52799645 | 8mer-1a | 52799638 | 52799659 | 145 | -17.74 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-381-3p | chr19 | 52799638 | 52799645 | 8mer-1a | 52799638 | 52799659 | 145 | -17.74 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-381-3p | chr19 | 52799638 | 52799645 | 8mer-1a | 52799638 | 52799659 | 145 | -17.74 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-381-3p | chr19 | 52799638 | 52799645 | 8mer-1a | 52799638 | 52799659 | 145 | -17.74 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-5682 | chr19 | 52797531 | 52797537 | 7mer-m8 | 52797530 | 52797548 | 144 | -14.83 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-5682 | chr19 | 52797531 | 52797537 | 7mer-m8 | 52797530 | 52797548 | 144 | -14.83 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-4775 | chr19 | 52797573 | 52797579 | 7mer-m8 | 52797572 | 52797593 | 140 | -1.81 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-4775 | chr19 | 52797573 | 52797579 | 7mer-m8 | 52797572 | 52797593 | 140 | -1.81 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-5585-3p | chr19 | 52798716 | 52798722 | 7mer-m8 | 52798715 | 52798736 | 145 | -10.54 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-5585-3p | chr19 | 52798716 | 52798722 | 7mer-m8 | 52798715 | 52798736 | 145 | -10.54 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000198538.11 | ENST00000438150.2 | ZNF28-203 | hsa-miR-5585-3p | chr19 | 52798716 | 52798722 | 7mer-m8 | 52798715 | 52798736 | 145 | -10.54 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000198538.11 | ENST00000457749.7 | ZNF28-204 | hsa-miR-5585-3p | chr19 | 52798716 | 52798722 | 7mer-m8 | 52798715 | 52798736 | 145 | -10.54 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ZNF28 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000457749.7 | protein_coding |  |  |
| ENST00000438150.2 | protein_coding |  |  |
| ENST00000339844.6 | protein_coding |  |  |
| ENST00000596559.5 | protein_coding |  |  |
| ENST00000594602.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_779839 | ENST00000457749.7 | chr19_52797866_- | 4100 | -1186.39 | -1179.89 | -1203.20 |
| ADediting_779840 | ENST00000457749.7 | chr19_52797871_- | 4095 | -1184.89 | -1179.89 | -1203.20 |
| ADediting_779841 | ENST00000457749.7 | chr19_52797933_- | 4033 | -1186.49 | -1179.89 | -1203.20 |
| ADediting_1558409 | ENST00000457749.7 | chr19_52797955_- | 4011 | -1182.90 | -1179.89 | -1203.20 |
| ADediting_779842 | ENST00000457749.7 | chr19_52798046_- | 3920 | -1179.89 | -1179.89 | -1203.20 |
| ADediting_779843 | ENST00000457749.7 | chr19_52798059_- | 3907 | -1180.19 | -1179.89 | -1203.20 |
| ADediting_779844 | ENST00000457749.7 | chr19_52798062_- | 3904 | -1185.09 | -1179.89 | -1203.20 |
| ADediting_779845 | ENST00000457749.7 | chr19_52798281_- | 3685 | -1179.49 | -1179.89 | -1203.20 |
| ADediting_779839 | ENST00000438150.2 | chr19_52797866_- | 4714 | -1369.20 | -1368.20 | -1393.90 |
| ADediting_779840 | ENST00000438150.2 | chr19_52797871_- | 4709 | -1371.30 | -1368.20 | -1393.90 |
| ADediting_779841 | ENST00000438150.2 | chr19_52797933_- | 4647 | -1369.10 | -1368.20 | -1393.90 |
| ADediting_1558409 | ENST00000438150.2 | chr19_52797955_- | 4625 | -1370.50 | -1368.20 | -1393.90 |
| ADediting_779842 | ENST00000438150.2 | chr19_52798046_- | 4534 | -1368.20 | -1368.20 | -1393.90 |
| ADediting_779843 | ENST00000438150.2 | chr19_52798059_- | 4521 | -1368.20 | -1368.20 | -1393.90 |
| ADediting_779844 | ENST00000438150.2 | chr19_52798062_- | 4518 | -1371.60 | -1368.20 | -1393.90 |
| ADediting_779845 | ENST00000438150.2 | chr19_52798281_- | 4299 | -1368.20 | -1368.20 | -1393.90 |
| ADediting_779848 | ENST00000438150.2 | chr19_52805161_- | 861 | -1368.10 | -1368.20 | -1393.90 |
| ADediting_779849 | ENST00000438150.2 | chr19_52805170_- | 852 | -1371.20 | -1368.20 | -1393.90 |
| ADediting_779850 | ENST00000438150.2 | chr19_52805184_- | 838 | -1370.30 | -1368.20 | -1393.90 |
| ADediting_779851 | ENST00000438150.2 | chr19_52805187_- | 835 | -1372.60 | -1368.20 | -1393.90 |
| ADediting_779852 | ENST00000438150.2 | chr19_52805194_- | 828 | -1370.30 | -1368.20 | -1393.90 |
| ADediting_779853 | ENST00000438150.2 | chr19_52805239_- | 783 | -1371.60 | -1368.20 | -1393.90 |
| ADediting_779854 | ENST00000438150.2 | chr19_52805540_- | 482 | -1371.00 | -1368.20 | -1393.90 |
| ADediting_779855 | ENST00000438150.2 | chr19_52805541_- | 481 | -1369.00 | -1368.20 | -1393.90 |
| ADediting_779856 | ENST00000438150.2 | chr19_52805544_- | 478 | -1368.20 | -1368.20 | -1393.90 |
| ADediting_779857 | ENST00000438150.2 | chr19_52805928_- | 94 | -1371.00 | -1368.20 | -1393.90 |
| ADediting_779848 | ENST00000339844.6 | chr19_52805161_- | 430 | -213.40 | -211.70 | -219.30 |
| ADediting_779849 | ENST00000339844.6 | chr19_52805170_- | 421 | -212.10 | -211.70 | -219.30 |
| ADediting_779850 | ENST00000339844.6 | chr19_52805184_- | 407 | -212.10 | -211.70 | -219.30 |
| ADediting_779851 | ENST00000339844.6 | chr19_52805187_- | 404 | -211.70 | -211.70 | -219.30 |
| ADediting_779852 | ENST00000339844.6 | chr19_52805194_- | 397 | -211.00 | -211.70 | -219.30 |
| ADediting_779853 | ENST00000339844.6 | chr19_52805239_- | 352 | -216.80 | -211.70 | -219.30 |
| ADediting_779848 | ENST00000596559.5 | chr19_52805161_- | 219 | -171.40 | -170.10 | -179.60 |
| ADediting_779849 | ENST00000596559.5 | chr19_52805170_- | 210 | -173.00 | -170.10 | -179.60 |
| ADediting_779850 | ENST00000596559.5 | chr19_52805184_- | 196 | -169.80 | -170.10 | -179.60 |
| ADediting_779851 | ENST00000596559.5 | chr19_52805187_- | 193 | -173.00 | -170.10 | -179.60 |
| ADediting_779852 | ENST00000596559.5 | chr19_52805194_- | 186 | -170.10 | -170.10 | -179.60 |
| ADediting_779853 | ENST00000596559.5 | chr19_52805239_- | 141 | -174.30 | -170.10 | -179.60 |
| ADediting_779848 | ENST00000594602.5 | chr19_52805161_- | 346 | -200.10 | -198.80 | -206.00 |
| ADediting_779849 | ENST00000594602.5 | chr19_52805170_- | 337 | -200.50 | -198.80 | -206.00 |
| ADediting_779850 | ENST00000594602.5 | chr19_52805184_- | 323 | -199.20 | -198.80 | -206.00 |
| ADediting_779851 | ENST00000594602.5 | chr19_52805187_- | 320 | -198.90 | -198.80 | -206.00 |
| ADediting_779852 | ENST00000594602.5 | chr19_52805194_- | 313 | -198.10 | -198.80 | -206.00 |
| ADediting_779853 | ENST00000594602.5 | chr19_52805239_- | 268 | -203.90 | -198.80 | -206.00 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ZNF28 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_779843 | chr19_52798059_- | 0.00394278518693386 | 0.234051366557066 | 1.14391507081937e-07 | 0.416567873365452 | 0.629561183166211 | 0.0396998454137358 |
| CER | ADediting_779844 | chr19_52798062_- | 0.00404140024151887 | 0.233436369075064 | 6.06986854587128e-07 | 0.394041047940248 | 0.116720180004921 | 0.12862637439511 |
| CER | ADediting_779852 | chr19_52805194_- | 2.3058318294837e-05 | 0.338212094240739 | 1.12030705051909e-05 | 0.350157926705749 | 0.248373286128921 | 0.0948297112610458 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.55141947001194e-08 | 0.304390843700067 | 0.000808166688132956 | 0.189307681836369 | 1.14445581115072e-07 | 0.2955807632923 |
| AC | 8.47374803863674e-33 | 0.661191819835483 | 6.33843922080905e-18 | 0.509565001095219 | 1.16302743702339e-15 | 0.477768421992993 |
| PCC | 1.32583548024953e-10 | 0.443419035978605 | 3.64541615777255e-07 | 0.358123313161956 | 9.99483687302344e-10 | 0.42383380092215 |
| CER | 2.91486090183029e-41 | 0.840690983739723 | 1.23485516548591e-24 | 0.713531513953332 | 0.0178605397945862 | 0.193177719290296 |
| TCX | 9.58902256628707e-06 | 0.352669951799949 | 0.706908022416037 | -0.0309528220768764 | 2.87325490297869e-11 | 0.50913550252926 |
| FP | 8.18695378576905e-19 | 0.600371444432552 | 6.4616408180235e-16 | 0.557352367295019 | 7.29250920493654e-09 | 0.41659588602743 |
| IFG | 0.00343370326432998 | 0.562350145744434 | 0.000971965025713129 | 0.61893463868878 | 0.123132347230279 | 0.316566343184834 |
| PG | 7.18065901414896e-38 | 0.770771070074157 | 3.42507850457587e-19 | 0.594938592592279 | 0.317331083235256 | 0.0737175794301432 |
| STG | 1.52467872429417e-08 | 0.569954076665697 | 0.000102706222061283 | 0.411057127715697 | 0.00626607387828009 | 0.295972957290645 |
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Relation with AD stages for ZNF28 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000686060703671724 | 0.321706191236636 |
| TCX | 1.55945157335062e-07 | 0.48312762950345 |
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RelatedDrugs for ZNF28 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF28 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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