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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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Gene summary for USF2 |
 Gene summary |
| Gene information | Gene symbol | USF2 | Gene ID | 7392 |
| Gene name | upstream transcription factor 2, c-fos interacting | |
| Synonyms | FIP|bHLHb12 | |
| Cytomap | 19q13.12 | |
| Type of gene | protein-coding | |
| Description | upstream stimulatory factor 2c-fos interacting proteinclass B basic helix-loop-helix protein 12major late transcription factor 2 | |
| Modification date | 20200313 | |
| UniProtAcc | Q15853, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for USF2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_740260(35273632, +), ADediting_740261(35273644, +), ADediting_740262(35273651, +), ADediting_740263(35273657, +), ADediting_740264(35273658, +), ADediting_740265(35273662, +), ADediting_740266(35273765, +), ADediting_740267(35273790, +), ADediting_740268(35273794, +), ADediting_740269(35274569, +), ADediting_740270(35274592, +), ADediting_740271(35274611, +), ADediting_740272(35274624, +), ADediting_740273(35274637, +), ADediting_740274(35274641, +), ADediting_740275(35274642, +), ADediting_740276(35274643, +), ADediting_740277(35274652, +), ADediting_740278(35274656, +), ADediting_740279(35274660, +), ADediting_740280(35274685, +), ADediting_740281(35274695, +), ADediting_740282(35274703, +), ADediting_740283(35274715, +), ADediting_740284(35274716, +), ADediting_740285(35274726, +), ADediting_740286(35274738, +), ADediting_740287(35274761, +), ADediting_740288(35275110, +), ADediting_740289(35275111, +), ADediting_740290(35275116, +), ADediting_740291(35275124, +), ADediting_740292(35275147, +), ADediting_740293(35275164, +), ADediting_740294(35275173, +), ADediting_740295(35275176, +), ADediting_740296(35275186, +), ADediting_740297(35275208, +), ADediting_740298(35275212, +), ADediting_740299(35275256, +), ADediting_740300(35275281, +), ADediting_740301(35275323, +), ADediting_1555271(35273579, +), ADediting_1555272(35273637, +), ADediting_1555273(35274568, +), ADediting_1555274(35274582, +), ADediting_1555275(35274587, +), ADediting_1555276(35274651, +), ADediting_1555277(35274691, +), ADediting_1555278(35275230, +), ADediting_1555279(35275309, +), ADediting_1555280(35276252, +), |
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RNA editing positional annotations for USF2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_740260 | chr19_35273632_+ | intronic |
| ADediting_740261 | chr19_35273644_+ | intronic |
| ADediting_740262 | chr19_35273651_+ | intronic |
| ADediting_740263 | chr19_35273657_+ | intronic |
| ADediting_740264 | chr19_35273658_+ | intronic |
| ADediting_740265 | chr19_35273662_+ | intronic |
| ADediting_740266 | chr19_35273765_+ | intronic |
| ADediting_740267 | chr19_35273790_+ | intronic |
| ADediting_740268 | chr19_35273794_+ | intronic |
| ADediting_740269 | chr19_35274569_+ | intronic |
| ADediting_740270 | chr19_35274592_+ | intronic |
| ADediting_740271 | chr19_35274611_+ | intronic |
| ADediting_740272 | chr19_35274624_+ | intronic |
| ADediting_740273 | chr19_35274637_+ | intronic |
| ADediting_740274 | chr19_35274641_+ | intronic |
| ADediting_740275 | chr19_35274642_+ | intronic |
| ADediting_740276 | chr19_35274643_+ | intronic |
| ADediting_740277 | chr19_35274652_+ | intronic |
| ADediting_740278 | chr19_35274656_+ | intronic |
| ADediting_740279 | chr19_35274660_+ | intronic |
| ADediting_740280 | chr19_35274685_+ | intronic |
| ADediting_740281 | chr19_35274695_+ | intronic |
| ADediting_740282 | chr19_35274703_+ | intronic |
| ADediting_740283 | chr19_35274715_+ | intronic |
| ADediting_740284 | chr19_35274716_+ | intronic |
| ADediting_740285 | chr19_35274726_+ | intronic |
| ADediting_740286 | chr19_35274738_+ | intronic |
| ADediting_740287 | chr19_35274761_+ | intronic |
| ADediting_740288 | chr19_35275110_+ | intronic |
| ADediting_740289 | chr19_35275111_+ | intronic |
| ADediting_740290 | chr19_35275116_+ | intronic |
| ADediting_740291 | chr19_35275124_+ | intronic |
| ADediting_740292 | chr19_35275147_+ | intronic |
| ADediting_740293 | chr19_35275164_+ | intronic |
| ADediting_740294 | chr19_35275173_+ | intronic |
| ADediting_740295 | chr19_35275176_+ | intronic |
| ADediting_740296 | chr19_35275186_+ | intronic |
| ADediting_740297 | chr19_35275208_+ | intronic |
| ADediting_740298 | chr19_35275212_+ | intronic |
| ADediting_740299 | chr19_35275256_+ | intronic |
| ADediting_740300 | chr19_35275281_+ | intronic |
| ADediting_740301 | chr19_35275323_+ | intronic |
| ADediting_1555271 | chr19_35273579_+ | intronic |
| ADediting_1555272 | chr19_35273637_+ | intronic |
| ADediting_1555273 | chr19_35274568_+ | intronic |
| ADediting_1555274 | chr19_35274582_+ | intronic |
| ADediting_1555275 | chr19_35274587_+ | intronic |
| ADediting_1555276 | chr19_35274651_+ | intronic |
| ADediting_1555277 | chr19_35274691_+ | intronic |
| ADediting_1555278 | chr19_35275230_+ | intronic |
| ADediting_1555279 | chr19_35275309_+ | intronic |
| ADediting_1555280 | chr19_35276252_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_740260 | chr19_35273632_+ | SINE | Alu | Name=AluJr |
| ADediting_740261 | chr19_35273644_+ | SINE | Alu | Name=AluJr |
| ADediting_740262 | chr19_35273651_+ | SINE | Alu | Name=AluJr |
| ADediting_740263 | chr19_35273657_+ | SINE | Alu | Name=AluJr |
| ADediting_740264 | chr19_35273658_+ | SINE | Alu | Name=AluJr |
| ADediting_740265 | chr19_35273662_+ | SINE | Alu | Name=AluJr |
| ADediting_740266 | chr19_35273765_+ | SINE | Alu | Name=AluJr |
| ADediting_740267 | chr19_35273790_+ | SINE | Alu | Name=AluJr |
| ADediting_740268 | chr19_35273794_+ | SINE | Alu | Name=AluJr |
| ADediting_740269 | chr19_35274569_+ | SINE | Alu | Name=AluJb |
| ADediting_740270 | chr19_35274592_+ | SINE | Alu | Name=AluJb |
| ADediting_740271 | chr19_35274611_+ | SINE | Alu | Name=AluJb |
| ADediting_740272 | chr19_35274624_+ | SINE | Alu | Name=AluJb |
| ADediting_740273 | chr19_35274637_+ | SINE | Alu | Name=AluJb |
| ADediting_740274 | chr19_35274641_+ | SINE | Alu | Name=AluJb |
| ADediting_740275 | chr19_35274642_+ | SINE | Alu | Name=AluJb |
| ADediting_740276 | chr19_35274643_+ | SINE | Alu | Name=AluJb |
| ADediting_740277 | chr19_35274652_+ | SINE | Alu | Name=AluJb |
| ADediting_740278 | chr19_35274656_+ | SINE | Alu | Name=AluJb |
| ADediting_740279 | chr19_35274660_+ | SINE | Alu | Name=AluJb |
| ADediting_740280 | chr19_35274685_+ | SINE | Alu | Name=AluJb |
| ADediting_740281 | chr19_35274695_+ | SINE | Alu | Name=AluJb |
| ADediting_740282 | chr19_35274703_+ | SINE | Alu | Name=AluJb |
| ADediting_740283 | chr19_35274715_+ | SINE | Alu | Name=AluJb |
| ADediting_740284 | chr19_35274716_+ | SINE | Alu | Name=AluJb |
| ADediting_740285 | chr19_35274726_+ | SINE | Alu | Name=AluJb |
| ADediting_740286 | chr19_35274738_+ | SINE | Alu | Name=AluJb |
| ADediting_740287 | chr19_35274761_+ | SINE | Alu | Name=AluJb |
| ADediting_740288 | chr19_35275110_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740289 | chr19_35275111_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740290 | chr19_35275116_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740291 | chr19_35275124_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740292 | chr19_35275147_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740293 | chr19_35275164_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740294 | chr19_35275173_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740295 | chr19_35275176_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740296 | chr19_35275186_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740297 | chr19_35275208_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740298 | chr19_35275212_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740299 | chr19_35275256_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740300 | chr19_35275281_+ | SINE | Alu | Name=AluSx1 |
| ADediting_740301 | chr19_35275323_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1555271 | chr19_35273579_+ | SINE | Alu | Name=AluJr |
| ADediting_1555272 | chr19_35273637_+ | SINE | Alu | Name=AluJr |
| ADediting_1555273 | chr19_35274568_+ | SINE | Alu | Name=AluJb |
| ADediting_1555274 | chr19_35274582_+ | SINE | Alu | Name=AluJb |
| ADediting_1555275 | chr19_35274587_+ | SINE | Alu | Name=AluJb |
| ADediting_1555276 | chr19_35274651_+ | SINE | Alu | Name=AluJb |
| ADediting_1555277 | chr19_35274691_+ | SINE | Alu | Name=AluJb |
| ADediting_1555278 | chr19_35275230_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1555279 | chr19_35275309_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1555280 | chr19_35276252_+ | SINE | Alu | Name=AluSz6 |
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RNA A-to-I editing events in the alternative splicing sites for USF2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for USF2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for USF2 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for USF2 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1555279 | chr19_35275309_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3189-3p | chr19 | 35275304 | 35275310 | 7mer-m8 | 35275288 | 35275311 | 153 | -26.36 |
| ADediting_1555279 | chr19_35275309_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-6813-3p | chr19 | 35275305 | 35275311 | 7mer-m8 | 35275292 | 35275312 | 140 | -11.59 |
| ADediting_740289 | chr19_35275111_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3672 | chr19 | 35275110 | 35275116 | 7mer-m8 | 35275090 | 35275117 | 143 | -16.65 |
| ADediting_740289 | chr19_35275111_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-6864-3p | chr19 | 35275110 | 35275116 | 7mer-m8 | 35275097 | 35275117 | 147 | -12.17 |
| ADediting_740289 | chr19_35275111_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-873-3p | chr19 | 35275109 | 35275116 | 8mer-1a | 35275095 | 35275116 | 140 | -14.47 |
| ADediting_740291 | chr19_35275124_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-6516-5p | chr19 | 35275121 | 35275127 | 7mer-m8 | 35275109 | 35275128 | 156 | -14.5 |
| ADediting_740292 | chr19_35275147_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3622a-3p | chr19 | 35275144 | 35275151 | 8mer-1a | 35275130 | 35275151 | 143 | -16 |
| ADediting_740292 | chr19_35275147_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3622b-3p | chr19 | 35275144 | 35275151 | 8mer-1a | 35275131 | 35275151 | 147 | -18.95 |
| ADediting_740295 | chr19_35275176_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3614-5p | chr19 | 35275170 | 35275176 | 7mer-m8 | 35275154 | 35275177 | 152 | -25.98 |
| ADediting_740295 | chr19_35275176_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-4691-3p | chr19 | 35275174 | 35275180 | 7mer-m8 | 35275154 | 35275181 | 151 | -28.72 |
| ADediting_740296 | chr19_35275186_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-17-3p | chr19 | 35275183 | 35275189 | 7mer-m8 | 35275168 | 35275190 | 158 | -20.42 |
| ADediting_740297 | chr19_35275208_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3934-5p | chr19 | 35275202 | 35275208 | 7mer-m8 | 35275188 | 35275209 | 156 | -28.27 |
| ADediting_740298 | chr19_35275212_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-548aa | chr19 | 35275211 | 35275217 | 7mer-m8 | 35275195 | 35275218 | 142 | -8.3 |
| ADediting_740298 | chr19_35275212_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-548ap-3p | chr19 | 35275211 | 35275217 | 7mer-m8 | 35275200 | 35275218 | 140 | -7.26 |
| ADediting_740298 | chr19_35275212_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-548t-3p | chr19 | 35275211 | 35275217 | 7mer-m8 | 35275195 | 35275218 | 142 | -8.3 |
| ADediting_740299 | chr19_35275256_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3940-3p | chr19 | 35275254 | 35275260 | 7mer-m8 | 35275243 | 35275261 | 144 | -24.53 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1555278 | chr19_35275230_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-4684-5p | chr19 | 35275228 | 35275234 | 7mer-m8 | 35275213 | 35275235 | 155 | -13.2 |
| ADediting_740288 | chr19_35275110_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-5186 | chr19 | 35275109 | 35275116 | 8mer-1a | 35275096 | 35275116 | 140 | -9.9 |
| ADediting_740289 | chr19_35275111_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-5186 | chr19 | 35275109 | 35275116 | 8mer-1a | 35275096 | 35275116 | 140 | -9.9 |
| ADediting_740292 | chr19_35275147_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3614-5p | chr19 | 35275145 | 35275151 | 7mer-1a | 35275128 | 35275151 | 147 | -20.42 |
| ADediting_740293 | chr19_35275164_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-4649-3p | chr19 | 35275159 | 35275165 | 7mer-m8 | 35275146 | 35275166 | 140 | -14.72 |
| ADediting_740293 | chr19_35275164_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-6857-3p | chr19 | 35275161 | 35275167 | 7mer-m8 | 35275148 | 35275168 | 140 | -11.48 |
| ADediting_740293 | chr19_35275164_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-873-3p | chr19 | 35275163 | 35275169 | 7mer-m8 | 35275148 | 35275170 | 148 | -21.01 |
| ADediting_740294 | chr19_35275173_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-12126 | chr19 | 35275169 | 35275176 | 8mer-1a | 35275153 | 35275176 | 147 | -16.86 |
| ADediting_740294 | chr19_35275173_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-887-5p | chr19 | 35275167 | 35275173 | 7mer-m8 | 35275155 | 35275174 | 143 | -20.14 |
| ADediting_740295 | chr19_35275176_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-5690 | chr19 | 35275174 | 35275180 | 7mer-m8 | 35275161 | 35275181 | 145 | -16.74 |
| ADediting_740298 | chr19_35275212_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-4661-5p | chr19 | 35275208 | 35275214 | 7mer-m8 | 35275194 | 35275215 | 149 | -18.52 |
| ADediting_740299 | chr19_35275256_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-3190-5p | chr19 | 35275251 | 35275257 | 7mer-m8 | 35275239 | 35275258 | 147 | -18.34 |
| ADediting_740299 | chr19_35275256_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-548s | chr19 | 35275250 | 35275256 | 7mer-m8 | 35275236 | 35275257 | 143 | -12.53 |
| ADediting_740300 | chr19_35275281_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-4649-3p | chr19 | 35275276 | 35275282 | 7mer-m8 | 35275263 | 35275283 | 147 | -18.42 |
| ADediting_740300 | chr19_35275281_+ | ENSG00000105698.16 | ENST00000600341.5 | USF2-213 | hsa-miR-544b | chr19 | 35275277 | 35275283 | 7mer-m8 | 35275264 | 35275284 | 153 | -18.39 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000105698.16 | ENST00000222305.8 | USF2-201 | hsa-miR-4512 | chr19 | 35279551 | 35279557 | 7mer-m8 | 35279539 | 35279558 | 150 | -29.29 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105698.16 | ENST00000343550.9 | USF2-202 | hsa-miR-4512 | chr19 | 35279551 | 35279557 | 7mer-m8 | 35279539 | 35279558 | 150 | -29.29 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105698.16 | ENST00000595068.5 | USF2-207 | hsa-miR-4512 | chr19 | 35279551 | 35279557 | 7mer-m8 | 35279539 | 35279558 | 150 | -29.29 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105698.16 | ENST00000599471.5 | USF2-211 | hsa-miR-4512 | chr19 | 35279551 | 35279557 | 7mer-m8 | 35279539 | 35279558 | 150 | -29.29 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for USF2 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000600341.5 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_740288 | ENST00000600341.5 | chr19_35275110_+ | 88 | -490.20 | -489.10 | -512.00 |
| ADediting_740289 | ENST00000600341.5 | chr19_35275111_+ | 89 | -491.00 | -489.10 | -512.00 |
| ADediting_740290 | ENST00000600341.5 | chr19_35275116_+ | 94 | -489.30 | -489.10 | -512.00 |
| ADediting_740291 | ENST00000600341.5 | chr19_35275124_+ | 102 | -491.90 | -489.10 | -512.00 |
| ADediting_740292 | ENST00000600341.5 | chr19_35275147_+ | 125 | -491.50 | -489.10 | -512.00 |
| ADediting_740293 | ENST00000600341.5 | chr19_35275164_+ | 142 | -490.10 | -489.10 | -512.00 |
| ADediting_740294 | ENST00000600341.5 | chr19_35275173_+ | 151 | -491.10 | -489.10 | -512.00 |
| ADediting_740295 | ENST00000600341.5 | chr19_35275176_+ | 154 | -490.60 | -489.10 | -512.00 |
| ADediting_740296 | ENST00000600341.5 | chr19_35275186_+ | 164 | -492.10 | -489.10 | -512.00 |
| ADediting_740297 | ENST00000600341.5 | chr19_35275208_+ | 186 | -490.40 | -489.10 | -512.00 |
| ADediting_740298 | ENST00000600341.5 | chr19_35275212_+ | 190 | -490.80 | -489.10 | -512.00 |
| ADediting_1555278 | ENST00000600341.5 | chr19_35275230_+ | 208 | -490.50 | -489.10 | -512.00 |
| ADediting_740299 | ENST00000600341.5 | chr19_35275256_+ | 234 | -494.70 | -489.10 | -512.00 |
| ADediting_740300 | ENST00000600341.5 | chr19_35275281_+ | 259 | -488.50 | -489.10 | -512.00 |
| ADediting_1555279 | ENST00000600341.5 | chr19_35275309_+ | 287 | -490.80 | -489.10 | -512.00 |
| ADediting_740301 | ENST00000600341.5 | chr19_35275323_+ | 301 | -491.90 | -489.10 | -512.00 |
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Relation with ADAR for USF2 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1555274 | chr19_35274582_+ | 3.35463487573113e-05 | 0.331808871810906 | 5.69126719701703e-08 | 0.42552218333432 | 0.00274613852474888 | 0.24288476325726 |
| CER | ADediting_740262 | chr19_35273651_+ | 0.0124736365936537 | 0.203560206830402 | 8.88251166629289e-06 | 0.353897971345409 | 0.000954671159690067 | 0.267052229164619 |
| CER | ADediting_740263 | chr19_35273657_+ | 0.0130363265598199 | 0.202309411592214 | 3.04450851831319e-05 | 0.333479299927829 | 0.205688842340686 | 0.103917719603455 |
| CER | ADediting_740264 | chr19_35273658_+ | 0.0126267102329141 | 0.203215124384811 | 7.55056336505162e-05 | 0.317444254548757 | 0.0188765821513177 | 0.191533926617928 |
| CER | ADediting_740268 | chr19_35273794_+ | 0.000496911477348702 | 0.28093961519511 | 2.06224749574848e-05 | 0.340091972842784 | 0.438479299875811 | 0.0637279673877821 |
| CER | ADediting_740270 | chr19_35274592_+ | 2.70262259172276e-11 | 0.509725940901705 | 4.23071090868291e-15 | 0.584218571953109 | 0.00337051560006843 | 0.237920016581322 |
| DLPFC | ADediting_740271 | chr19_35274611_+ | 0.0284400946781573 | 0.124468111743209 | 0.750328830218197 | 0.0181446873739366 | 1.81263588587042e-09 | 0.333101072111656 |
| CER | ADediting_740271 | chr19_35274611_+ | 1.56279780224026e-07 | 0.412479998408089 | 1.7329461163617e-08 | 0.44020127472732 | 0.000946125327998002 | 0.267248508633416 |
| TCX | ADediting_740271 | chr19_35274611_+ | 0.122545386690379 | 0.126632767071766 | 0.792998477953907 | 0.0216046477778277 | 1.07929757253042e-08 | 0.445858330940737 |
| CER | ADediting_740272 | chr19_35274624_+ | 0.000520104339135174 | 0.279992559473359 | 3.49791153961324e-05 | 0.331085671563789 | 0.41947302099342 | 0.0664013799573887 |
| CER | ADediting_740273 | chr19_35274637_+ | 5.65888998478046e-11 | 0.502522224532229 | 2.14971399301089e-07 | 0.408245625497581 | 0.0560520094565127 | 0.156349508885465 |
| CER | ADediting_740282 | chr19_35274703_+ | 3.29710685249548e-05 | 0.332107449746144 | 3.18940333465525e-05 | 0.332679858515291 | 0.0592445503911794 | 0.15438854925736 |
| CER | ADediting_740284 | chr19_35274716_+ | 6.13019330739499e-09 | 0.452483936302681 | 5.49489615075581e-11 | 0.502812126792752 | 0.00160510430224555 | 0.255451988681458 |
| TCX | ADediting_740284 | chr19_35274716_+ | 0.0143056182649907 | 0.199652844875165 | 0.245979852221182 | 0.0953089241078192 | 3.32787590592097e-05 | 0.331947150572719 |
| CER | ADediting_740289 | chr19_35275111_+ | 1.05889568151461e-05 | 0.351070730272381 | 0.0019031046235674 | 0.251533516800847 | 0.155570388816343 | 0.116532377745892 |
| CER | ADediting_740290 | chr19_35275116_+ | 3.3133181847634e-05 | 0.332022818245152 | 0.00297188781658084 | 0.24098196035591 | 0.278034133130933 | 0.0891383896416281 |
| TCX | ADediting_740290 | chr19_35275116_+ | 0.164404949164074 | 0.114109761020331 | 0.643195208105371 | -0.0381282636504151 | 1.31253506379653e-05 | 0.347578652156739 |
| CER | ADediting_740291 | chr19_35275124_+ | 6.7565346068766e-06 | 0.358246300452472 | 1.70117961058156e-05 | 0.343304644777833 | 0.425542588718196 | 0.0655401869599758 |
| CER | ADediting_740292 | chr19_35275147_+ | 1.09559340510979e-05 | 0.35051943859971 | 0.000150876402459139 | 0.304584383284628 | 0.261705353832841 | 0.0922171060068198 |
| DLPFC | ADediting_740297 | chr19_35275208_+ | 0.000830373391717072 | 0.188890639558686 | 0.0601285429530155 | 0.106894025787873 | 1.25739621562871e-09 | 0.336177058535196 |
| CER | ADediting_740297 | chr19_35275208_+ | 3.55023167357624e-10 | 0.483859097472567 | 1.60410274322369e-09 | 0.467644595433046 | 0.000468007701537055 | 0.282178699938998 |
| TCX | ADediting_740297 | chr19_35275208_+ | 0.0517195359687874 | 0.159163574543795 | 0.668734386912103 | 0.0352205081849245 | 4.84171863500124e-05 | 0.325401171647859 |
| DLPFC | ADediting_740298 | chr19_35275212_+ | 0.00752157767009143 | 0.151540682020983 | 0.419158670931131 | 0.0460462713283489 | 5.26282414680522e-09 | 0.323936954545258 |
| CER | ADediting_740298 | chr19_35275212_+ | 2.41504231916181e-10 | 0.487869191840609 | 1.15917911096303e-10 | 0.495367913009403 | 0.0154313746633244 | 0.197463713297184 |
| CER | ADediting_740299 | chr19_35275256_+ | 3.3825215382903e-06 | 0.368967594368023 | 2.47178725023626e-11 | 0.510584951881835 | 0.0719048332150029 | 0.147375935525773 |
| CER | ADediting_740300 | chr19_35275281_+ | 0.00011806550799584 | 0.309207445477825 | 0.000376524962930343 | 0.286628636673707 | 0.275331372132448 | 0.0896393581304987 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.77155536451691e-20 | 0.494001869412729 | 5.27533664932961e-28 | 0.569110341102845 | 5.56876460670829e-22 | 0.510566279382384 |
| AC | 1.27584103941476e-47 | 0.756398570811392 | 9.14371152957169e-35 | 0.676213149413474 | 7.54263139414811e-24 | 0.579750642030919 |
| PCC | 1.18615452207446e-10 | 0.444462941273854 | 1.04374881610544e-12 | 0.485861069123181 | 0.000499074139717735 | 0.249535937014237 |
| CER | 4.27298404686957e-11 | 0.50528040568012 | 1.08891755536426e-22 | 0.691886637516906 | 7.18289720417116e-07 | 0.391673416759846 |
| TCX | 1.6109957277006e-06 | 0.380050534327542 | 0.0167797212405417 | 0.195017850036539 | 6.99837276081712e-08 | 0.42289734921501 |
| FP | 0.000482767757003103 | 0.258945097561639 | 0.22327792432475 | -0.0917360146320463 | 2.5692387750913e-07 | 0.374680132923108 |
| IFG | 7.86185690030153e-08 | 0.849434835960083 | 3.77700346655897e-08 | 0.859360081503386 | 0.0169996509842784 | 0.472786156172137 |
| PG | 0.605622618775751 | -0.0381023993884972 | 0.153684400963039 | -0.105024622865231 | 1.5745598675808e-07 | 0.373026853659323 |
| STG | 0.000123582566937576 | 0.40669596892757 | 0.555802057589621 | 0.0651830813138188 | 5.36637512833298e-08 | 0.551653125661519 |
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Relation with AD stages for USF2 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_740270 | chr19_35274592_+ | 1.02347021219464e-05 | 0.410470149915125 |
| CER | ADediting_740271 | chr19_35274611_+ | 5.02657315338078e-05 | 0.37982812762696 |
| CER | ADediting_740272 | chr19_35274624_+ | 0.000173941720173846 | 0.353612727994664 |
| CER | ADediting_740284 | chr19_35274716_+ | 7.93586096728927e-05 | 0.37044430846346 |
| TCX | ADediting_740262 | chr19_35273651_+ | 0.00133416427824209 | 0.307691256588141 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.24624977752738e-05 | 0.406838204151179 |
| TCX | 5.73647844779818e-09 | 0.528604287914589 |
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RelatedDrugs for USF2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USF2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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